NMNAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.23156937
2DNA deamination (GO:0045006)5.46319242
3pyrimidine deoxyribonucleotide metabolic process (GO:0009219)5.21012816
4pyrimidine nucleotide catabolic process (GO:0006244)4.99739169
5protoporphyrinogen IX metabolic process (GO:0046501)4.85972241
6ribosomal small subunit assembly (GO:0000028)4.79001525
7protoporphyrinogen IX biosynthetic process (GO:0006782)4.66660878
8positive regulation of megakaryocyte differentiation (GO:0045654)4.56477582
9heme biosynthetic process (GO:0006783)4.53137593
10hemoglobin metabolic process (GO:0020027)4.36588812
11cellular response to thyroid hormone stimulus (GO:0097067)4.14200133
12thrombin receptor signaling pathway (GO:0070493)4.06499821
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.96479214
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96479214
15deoxyribonucleotide catabolic process (GO:0009264)3.95349632
16aerobic respiration (GO:0009060)3.92124341
17porphyrin-containing compound biosynthetic process (GO:0006779)3.91792934
18positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.87438960
19regulation of megakaryocyte differentiation (GO:0045652)3.85243054
20oxidative phosphorylation (GO:0006119)3.83951515
21heme metabolic process (GO:0042168)3.83537546
22short-chain fatty acid metabolic process (GO:0046459)3.81259935
23positive regulation of granulocyte differentiation (GO:0030854)3.77051600
24oxygen transport (GO:0015671)3.76658755
25blood coagulation, intrinsic pathway (GO:0007597)3.76251107
26deoxyribose phosphate catabolic process (GO:0046386)3.75278766
27potassium ion export (GO:0071435)3.61189896
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.56991598
29NADH dehydrogenase complex assembly (GO:0010257)3.56991598
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56991598
31protein complex biogenesis (GO:0070271)3.56538408
32tetrapyrrole biosynthetic process (GO:0033014)3.54097327
33protein neddylation (GO:0045116)3.52080657
34granulocyte differentiation (GO:0030851)3.46577987
35gas transport (GO:0015669)3.38035043
36antigen processing and presentation of endogenous antigen (GO:0019883)3.32117564
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30902788
38telomere maintenance via semi-conservative replication (GO:0032201)3.30689675
39porphyrin-containing compound metabolic process (GO:0006778)3.30610947
40regulation of skeletal muscle contraction (GO:0014819)3.29998738
41positive regulation of gamma-delta T cell activation (GO:0046645)3.29803829
42antigen processing and presentation via MHC class Ib (GO:0002475)3.29611680
43mitochondrial calcium ion transport (GO:0006851)3.28583961
44actin-myosin filament sliding (GO:0033275)3.27228348
45muscle filament sliding (GO:0030049)3.27228348
46negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25393179
47platelet dense granule organization (GO:0060155)3.21242248
48mitochondrial respiratory chain complex assembly (GO:0033108)3.18923667
492-deoxyribonucleotide metabolic process (GO:0009394)3.10205670
50DNA strand elongation involved in DNA replication (GO:0006271)3.09614478
51response to thyroid hormone (GO:0097066)3.08669269
52glycerol ether metabolic process (GO:0006662)3.06799070
53platelet formation (GO:0030220)3.06576401
54deoxyribose phosphate metabolic process (GO:0019692)3.06198071
55ubiquinone biosynthetic process (GO:0006744)3.03863977
56viral transcription (GO:0019083)3.02914925
57response to interferon-beta (GO:0035456)3.01207000
58regulation of histone H3-K9 methylation (GO:0051570)2.98127134
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97859935
60erythrocyte maturation (GO:0043249)2.97047301
61positive regulation of histone H3-K4 methylation (GO:0051571)2.96060666
62DNA strand elongation (GO:0022616)2.95812148
63hydrogen peroxide catabolic process (GO:0042744)2.95299500
64ether metabolic process (GO:0018904)2.93364637
65positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91808885
66cardiolipin metabolic process (GO:0032048)2.91321041
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87858473
68telomere maintenance via recombination (GO:0000722)2.87411528
69purinergic nucleotide receptor signaling pathway (GO:0035590)2.86055456
70meiotic chromosome segregation (GO:0045132)2.85703250
71endothelium development (GO:0003158)2.83969738
72translational termination (GO:0006415)2.83584237
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83003745
74creatine metabolic process (GO:0006600)2.82374732
75pigment biosynthetic process (GO:0046148)2.81770428
76deoxyribose phosphate biosynthetic process (GO:0046385)2.78898245
772-deoxyribonucleotide biosynthetic process (GO:0009265)2.78898245
78branched-chain amino acid metabolic process (GO:0009081)2.77514550
79branched-chain amino acid catabolic process (GO:0009083)2.76796433
80translational elongation (GO:0006414)2.76684008
81NADH metabolic process (GO:0006734)2.76446378
82respiratory chain complex IV assembly (GO:0008535)2.73325010
83positive regulation of B cell differentiation (GO:0045579)2.72352291
84cellular respiration (GO:0045333)2.71760918
85protein targeting to ER (GO:0045047)2.70892954
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70453417
87L-phenylalanine catabolic process (GO:0006559)2.70453417
88cotranslational protein targeting to membrane (GO:0006613)2.70014482
89fatty acid beta-oxidation (GO:0006635)2.69701694
90pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.69679801
91deoxyribonucleotide metabolic process (GO:0009262)2.69229246
92L-phenylalanine metabolic process (GO:0006558)2.68435497
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68435497
94base-excision repair, AP site formation (GO:0006285)2.68029213
95positive regulation of erythrocyte differentiation (GO:0045648)2.67879678
96valine metabolic process (GO:0006573)2.67477359
97positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.66911016
98sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66886512
99regulation of RIG-I signaling pathway (GO:0039535)2.65899681
100proteasome assembly (GO:0043248)2.65853396
101endosome to melanosome transport (GO:0035646)2.65775051
102endosome to pigment granule transport (GO:0043485)2.65775051
103platelet aggregation (GO:0070527)2.64726430
104myeloid cell development (GO:0061515)2.64685514
105lipoxygenase pathway (GO:0019372)2.62641116
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58889860
107respiratory electron transport chain (GO:0022904)2.58434814
108ether lipid metabolic process (GO:0046485)2.58331187
109protein localization to endoplasmic reticulum (GO:0070972)2.57578125
110definitive hemopoiesis (GO:0060216)2.57339126
111daunorubicin metabolic process (GO:0044597)2.57223556
112polyketide metabolic process (GO:0030638)2.57223556
113doxorubicin metabolic process (GO:0044598)2.57223556
114response to methylmercury (GO:0051597)2.56990036
115telomere maintenance via telomere lengthening (GO:0010833)2.56281628
116mitotic recombination (GO:0006312)2.56086594
117fatty acid oxidation (GO:0019395)2.55083381
118erythrocyte differentiation (GO:0030218)2.54739238
119ubiquinone metabolic process (GO:0006743)2.53809353
120purine nucleobase metabolic process (GO:0006144)2.53788849
121secretory granule organization (GO:0033363)2.53280602
122electron transport chain (GO:0022900)2.53225891
123negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52866077
124negative regulation of calcium ion transmembrane transport (GO:1903170)2.52866077
125negative regulation of erythrocyte differentiation (GO:0045647)2.52323375
126purine-containing compound salvage (GO:0043101)2.52136660
127quinone biosynthetic process (GO:1901663)2.51614655
128negative regulation of viral genome replication (GO:0045071)2.51508634
129IMP biosynthetic process (GO:0006188)2.49924560
130regulation of necroptotic process (GO:0060544)2.45503711
131necroptotic process (GO:0070266)2.45188378
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43489007
133regulation of interleukin-12 biosynthetic process (GO:0045075)2.42148470
134regulation of erythrocyte differentiation (GO:0045646)2.41853004
135translesion synthesis (GO:0019985)2.41063931
136cytochrome complex assembly (GO:0017004)2.40753974
137iron-sulfur cluster assembly (GO:0016226)2.40477192
138metallo-sulfur cluster assembly (GO:0031163)2.40477192
139signal peptide processing (GO:0006465)2.40248891
140cellular response to interferon-beta (GO:0035458)2.39206386
141erythrocyte development (GO:0048821)2.38717793
142telomere maintenance (GO:0000723)2.38513791
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.38269146
144organic cation transport (GO:0015695)2.37712325
145DNA replication initiation (GO:0006270)2.36644985
146negative regulation of granulocyte differentiation (GO:0030853)2.35748803
147response to interferon-alpha (GO:0035455)2.34504561
148tetrapyrrole metabolic process (GO:0033013)2.34317714
149telomere organization (GO:0032200)2.33731198
150mitochondrial RNA metabolic process (GO:0000959)2.32870638
151pteridine-containing compound biosynthetic process (GO:0042559)2.32849861
152folic acid-containing compound biosynthetic process (GO:0009396)2.32829734
153NIK/NF-kappaB signaling (GO:0038061)2.32708650
154lysine catabolic process (GO:0006554)2.32603985
155lysine metabolic process (GO:0006553)2.32603985
156centriole assembly (GO:0098534)2.32338423
157embryonic hemopoiesis (GO:0035162)2.31402418
158ribosomal small subunit biogenesis (GO:0042274)2.29630623
159neutrophil activation involved in immune response (GO:0002283)2.28977033
160IMP metabolic process (GO:0046040)2.27585207
161response to type I interferon (GO:0034340)2.27474069
162megakaryocyte development (GO:0035855)2.26606080
163type I interferon signaling pathway (GO:0060337)2.26093357
164cellular response to type I interferon (GO:0071357)2.26093357
165DNA unwinding involved in DNA replication (GO:0006268)2.24933290
166toxin transport (GO:1901998)2.24784200
167T cell apoptotic process (GO:0070231)2.24278644
168sperm-egg recognition (GO:0035036)2.22568022
169regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.22381990
170fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.21231373
171maturation of SSU-rRNA (GO:0030490)2.21072250
172response to protozoan (GO:0001562)2.20192361
173response to peptidoglycan (GO:0032494)2.19636493
174regulation of gamma-delta T cell activation (GO:0046643)2.18954439
175defense response to protozoan (GO:0042832)2.18872346
176positive regulation of natural killer cell differentiation (GO:0032825)2.17610443
177Arp2/3 complex-mediated actin nucleation (GO:0034314)2.16838220
178pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.16172753
179tRNA methylation (GO:0030488)2.14207155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.89841149
2E2F7_22180533_ChIP-Seq_HELA_Human5.55874973
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.29178311
4SCL_19346495_ChIP-Seq_HPC-7_Human3.25874780
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14172776
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74369902
7GATA1_22025678_ChIP-Seq_K562_Human2.71646757
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64462552
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54906255
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54370909
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46482234
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43816343
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29301925
14* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26732095
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.14448022
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04392715
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03167325
18* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03003998
19GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.01800728
20SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.01616976
21GATA2_19941826_ChIP-Seq_K562_Human2.01003059
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00451670
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94239769
24BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.93398985
25ERG_20887958_ChIP-Seq_HPC-7_Mouse1.85442846
26* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.84688878
27* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.84482018
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80498412
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79280289
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78462092
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77753700
32* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77299396
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76808982
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74042053
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73814777
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70451970
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70123767
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70058842
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69115742
40VDR_21846776_ChIP-Seq_THP-1_Human1.68112737
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67479704
42SPI1_23547873_ChIP-Seq_NB4_Human1.67299982
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.67297928
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66752676
45HTT_18923047_ChIP-ChIP_STHdh_Human1.65683939
46* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64860060
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.62000957
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60839002
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60506035
50* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.59244427
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58378223
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.57173982
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56116644
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55601696
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.53381713
56MYC_22102868_ChIP-Seq_BL_Human1.52746535
57VDR_23849224_ChIP-Seq_CD4+_Human1.51445767
58* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50780401
59EZH2_22144423_ChIP-Seq_EOC_Human1.50557501
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.49015131
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.48710387
62FOXP3_21729870_ChIP-Seq_TREG_Human1.48375223
63MYB_26560356_Chip-Seq_TH2_Human1.46818589
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46685698
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45743678
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45318356
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44923538
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.44531191
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.43849147
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42627267
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.38944052
72MYB_26560356_Chip-Seq_TH1_Human1.38635106
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37091625
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36029216
75DCP1A_22483619_ChIP-Seq_HELA_Human1.35745606
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.35569337
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.34791119
78BCL6_27268052_Chip-Seq_Bcells_Human1.33254243
79MAF_26560356_Chip-Seq_TH1_Human1.31630631
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31117481
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.30903223
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.30821883
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30672699
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29951900
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29919724
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.28923393
87IGF1R_20145208_ChIP-Seq_DFB_Human1.27308941
88* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26176272
89VDR_24763502_ChIP-Seq_THP-1_Human1.24556496
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24512311
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23795201
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.23390170
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23075495
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21107308
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19556877
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17995842
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.16046925
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15772431
99SPI1_20517297_ChIP-Seq_HL60_Human1.15419074
100* P300_27268052_Chip-Seq_Bcells_Human1.13988300
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13608497
102AR_21909140_ChIP-Seq_LNCAP_Human1.13289423
103XRN2_22483619_ChIP-Seq_HELA_Human1.13259318
104UTX_26944678_Chip-Seq_JUKART_Human1.12155018
105* BCOR_27268052_Chip-Seq_Bcells_Human1.11977498
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10269617
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09627302
108STAT1_20625510_ChIP-Seq_HELA_Human1.08431661
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05778796
110GABP_19822575_ChIP-Seq_HepG2_Human1.05361724
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05076890
112ZNF263_19887448_ChIP-Seq_K562_Human1.04980949
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03902929
114CIITA_25753668_ChIP-Seq_RAJI_Human1.03508286
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02520927
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00217123
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00122045
118KDM5A_27292631_Chip-Seq_BREAST_Human1.00119794
119PU_27001747_Chip-Seq_BMDM_Mouse1.00069829
120TP53_22573176_ChIP-Seq_HFKS_Human0.99419453
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99339867
122NANOG_20526341_ChIP-Seq_ESCs_Human0.98257036
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98095802
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98081932
125NCOR1_26117541_ChIP-Seq_K562_Human0.96990117
126GATA1_19941826_ChIP-Seq_K562_Human0.96947308
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96425207
128CTCF_21964334_Chip-Seq_Bcells_Human0.95975582
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95445110
130RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94936733
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93628842
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93421413
133CTCF_26484167_Chip-Seq_Bcells_Mouse0.92672354
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92400744
135TFEB_21752829_ChIP-Seq_HELA_Human0.92188552
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89002022
137SPI1_23127762_ChIP-Seq_K562_Human0.87847111
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86115904
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84583239
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83525926
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82791849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.39976292
2MP0003656_abnormal_erythrocyte_physiolo3.23074841
3MP0002396_abnormal_hematopoietic_system3.12366859
4MP0004145_abnormal_muscle_electrophysio2.99521822
5MP0001835_abnormal_antigen_presentation2.69471895
6MP0002837_dystrophic_cardiac_calcinosis2.67806391
7MP0000685_abnormal_immune_system2.59354248
8MP0001545_abnormal_hematopoietic_system2.39816395
9MP0005397_hematopoietic_system_phenotyp2.39816395
10MP0009785_altered_susceptibility_to2.36592002
11MP0003718_maternal_effect2.30364250
12MP0005451_abnormal_body_composition2.21184003
13MP0005464_abnormal_platelet_physiology2.15936142
14MP0004808_abnormal_hematopoietic_stem2.13294397
15MP0000490_abnormal_crypts_of2.09777477
16MP0008057_abnormal_DNA_replication2.07805923
17MP0005410_abnormal_fertilization2.05270862
18MP0004036_abnormal_muscle_relaxation1.97022110
19MP0003436_decreased_susceptibility_to1.95213521
20MP0003195_calcinosis1.91251187
21MP0005671_abnormal_response_to1.87497842
22MP0002139_abnormal_hepatobiliary_system1.85805992
23MP0003724_increased_susceptibility_to1.84340636
24MP0005025_abnormal_response_to1.83105475
25MP0006036_abnormal_mitochondrial_physio1.82129103
26MP0008004_abnormal_stomach_pH1.79001822
27MP0002398_abnormal_bone_marrow1.76784023
28MP0005174_abnormal_tail_pigmentation1.76301722
29MP0001800_abnormal_humoral_immune1.73336538
30MP0006054_spinal_hemorrhage1.70832297
31MP0008058_abnormal_DNA_repair1.70688159
32MP0002138_abnormal_hepatobiliary_system1.68708765
33MP0009764_decreased_sensitivity_to1.65883582
34MP0004215_abnormal_myocardial_fiber1.65644797
35MP0000372_irregular_coat_pigmentation1.63641586
36MP0005360_urolithiasis1.63593972
37MP0002419_abnormal_innate_immunity1.62708730
38MP0002723_abnormal_immune_serum1.60938790
39MP0005075_abnormal_melanosome_morpholog1.60267918
40MP0002452_abnormal_antigen_presenting1.58927240
41MP0002166_altered_tumor_susceptibility1.58871712
42MP0005000_abnormal_immune_tolerance1.57828268
43MP0000689_abnormal_spleen_morphology1.57292632
44MP0002148_abnormal_hypersensitivity_rea1.57029426
45MP0004084_abnormal_cardiac_muscle1.56028871
46MP0001790_abnormal_immune_system1.54606390
47MP0005387_immune_system_phenotype1.54606390
48MP0003763_abnormal_thymus_physiology1.52872287
49MP0010155_abnormal_intestine_physiology1.52111701
50MP0010094_abnormal_chromosome_stability1.51308005
51MP0002420_abnormal_adaptive_immunity1.50360741
52MP0002722_abnormal_immune_system1.50153199
53MP0001853_heart_inflammation1.49103174
54MP0001819_abnormal_immune_cell1.48110877
55MP0005646_abnormal_pituitary_gland1.48049863
56MP0002638_abnormal_pupillary_reflex1.44092967
57MP0002429_abnormal_blood_cell1.42442447
58MP0003111_abnormal_nucleus_morphology1.42346098
59MP0005085_abnormal_gallbladder_physiolo1.40192670
60MP0000716_abnormal_immune_system1.40180845
61MP0000465_gastrointestinal_hemorrhage1.40155964
62MP0008469_abnormal_protein_level1.38739477
63MP0003646_muscle_fatigue1.38402877
64MP0009333_abnormal_splenocyte_physiolog1.37986307
65MP0005365_abnormal_bile_salt1.36288291
66MP0003866_abnormal_defecation1.34784353
67MP0003186_abnormal_redox_activity1.33099861
68MP0001845_abnormal_inflammatory_respons1.31392309
69MP0002006_tumorigenesis1.30062589
70MP0001873_stomach_inflammation1.29896021
71MP0002405_respiratory_system_inflammati1.28613240
72MP0005330_cardiomyopathy1.25944781
73MP0008789_abnormal_olfactory_epithelium1.25493029
74MP0005535_abnormal_body_temperature1.24068218
75MP0003252_abnormal_bile_duct1.23278896
76MP0003693_abnormal_embryo_hatching1.20546580
77MP0005636_abnormal_mineral_homeostasis1.18893056
78MP0006035_abnormal_mitochondrial_morpho1.17724521
79MP0003077_abnormal_cell_cycle1.17144224
80MP0005084_abnormal_gallbladder_morpholo1.16965980
81MP0005266_abnormal_metabolism1.16026440
82MP0008007_abnormal_cellular_replicative1.16007914
83MP0008775_abnormal_heart_ventricle1.15765831
84MP0001764_abnormal_homeostasis1.13725388
85MP0005666_abnormal_adipose_tissue1.13200253
86MP0003191_abnormal_cellular_cholesterol1.10163108
87MP0000609_abnormal_liver_physiology1.10090643
88MP0003806_abnormal_nucleotide_metabolis1.08842153
89MP0002106_abnormal_muscle_physiology1.08180785
90MP0002095_abnormal_skin_pigmentation1.07641504
91MP0000703_abnormal_thymus_morphology1.07473933
92MP0005319_abnormal_enzyme/_coenzyme1.06681943
93MP0000230_abnormal_systemic_arterial1.05809479
94MP0002971_abnormal_brown_adipose1.04531037
95MP0005083_abnormal_biliary_tract1.04294147
96MP0002019_abnormal_tumor_incidence1.03946351
97MP0009697_abnormal_copulation1.03380850
98MP0009763_increased_sensitivity_to1.02110710
99MP0008872_abnormal_physiological_respon0.99755720
100MP0003300_gastrointestinal_ulcer0.99465538
101MP0008995_early_reproductive_senescence0.98914812
102MP0003011_delayed_dark_adaptation0.98673354
103MP0002877_abnormal_melanocyte_morpholog0.98356156
104MP0010329_abnormal_lipoprotein_level0.95999825
105MP0005394_taste/olfaction_phenotype0.95593604
106MP0005499_abnormal_olfactory_system0.95593604
107MP0002078_abnormal_glucose_homeostasis0.93006177
108MP0004130_abnormal_muscle_cell0.92904751
109MP0005584_abnormal_enzyme/coenzyme_acti0.92528955
110MP0003786_premature_aging0.90947002
111MP0000747_muscle_weakness0.90752603
112MP0009643_abnormal_urine_homeostasis0.90299399
113MP0005670_abnormal_white_adipose0.90277169
114MP0004142_abnormal_muscle_tone0.90069693
115MP0001666_abnormal_nutrient_absorption0.90054499
116MP0003698_abnormal_male_reproductive0.89073283
117MP0005058_abnormal_lysosome_morphology0.88470491
118MP0008875_abnormal_xenobiotic_pharmacok0.88202002
119MP0009278_abnormal_bone_marrow0.87873563
120MP0002269_muscular_atrophy0.87463876
121MP0001533_abnormal_skeleton_physiology0.87345872
122MP0001984_abnormal_olfaction0.85857867
123MP0000598_abnormal_liver_morphology0.85660910
124MP0001661_extended_life_span0.84970611
125MP0000751_myopathy0.84159402
126MP0002132_abnormal_respiratory_system0.83895151
127MP0005369_muscle_phenotype0.83485737
128MP0003172_abnormal_lysosome_physiology0.83337871
129MP0003638_abnormal_response/metabolism_0.83269820
130MP0005620_abnormal_muscle_contractility0.83152329
131MP0004947_skin_inflammation0.82655352
132MP0003868_abnormal_feces_composition0.82147312
133MP0004085_abnormal_heartbeat0.82102990
134MP0000313_abnormal_cell_death0.81758147
135MP0000015_abnormal_ear_pigmentation0.81428565
136MP0005332_abnormal_amino_acid0.80958215
137MP0001929_abnormal_gametogenesis0.80164940
138MP0002118_abnormal_lipid_homeostasis0.80098524
139MP0006276_abnormal_autonomic_nervous0.79698822
140MP0000749_muscle_degeneration0.79624707
141MP0000343_altered_response_to0.78275064
142MP0009765_abnormal_xenobiotic_induced0.75553166
143MP0001986_abnormal_taste_sensitivity0.74905449
144MP0005220_abnormal_exocrine_pancreas0.74828760
145MP0002102_abnormal_ear_morphology0.74640798
146MP0002332_abnormal_exercise_endurance0.74504683
147MP0004957_abnormal_blastocyst_morpholog0.74447819
148MP0004087_abnormal_muscle_fiber0.73996114
149MP0001485_abnormal_pinna_reflex0.71972437
150MP0002972_abnormal_cardiac_muscle0.69153934
151MP0000358_abnormal_cell_content/0.68244183
152MP0005376_homeostasis/metabolism_phenot0.66745943
153MP0008874_decreased_physiological_sensi0.64106109
154MP0002822_catalepsy0.63658105
155MP0005645_abnormal_hypothalamus_physiol0.60371629
156MP0001663_abnormal_digestive_system0.59850215
157MP0001529_abnormal_vocalization0.59733329
158MP0009642_abnormal_blood_homeostasis0.59378718

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.97068757
2Abnormal number of erythroid precursors (HP:0012131)4.42088721
3Thrombocytosis (HP:0001894)4.25070076
4Abnormality of cells of the erythroid lineage (HP:0012130)4.11804398
5Exercise-induced myalgia (HP:0003738)4.01047986
6Increased mean platelet volume (HP:0011877)3.87920751
7Menorrhagia (HP:0000132)3.71724396
8Prolonged bleeding time (HP:0003010)3.71417951
9Muscle fiber inclusion bodies (HP:0100299)3.70530533
10Nemaline bodies (HP:0003798)3.66559537
11Severe visual impairment (HP:0001141)3.66136934
12Abnormal platelet volume (HP:0011876)3.56630716
13Petechiae (HP:0000967)3.53370604
14Poikilocytosis (HP:0004447)3.51270817
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.49761651
16Acute encephalopathy (HP:0006846)3.44611342
17Paralysis (HP:0003470)3.42814071
18Reduced antithrombin III activity (HP:0001976)3.42147892
19Abnormal mitochondria in muscle tissue (HP:0008316)3.27402726
20Acute necrotizing encephalopathy (HP:0006965)3.22583779
21Myositis (HP:0100614)3.14374581
22Cerebral palsy (HP:0100021)3.12967970
23Acanthocytosis (HP:0001927)3.05259691
24Mitochondrial inheritance (HP:0001427)3.00380830
25Myoglobinuria (HP:0002913)2.99412789
26Epistaxis (HP:0000421)2.96670981
27Hyperbilirubinemia (HP:0002904)2.93851556
28IgM deficiency (HP:0002850)2.88912980
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86802824
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86802824
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77377971
32Elevated erythrocyte sedimentation rate (HP:0003565)2.76697744
33Increased intramyocellular lipid droplets (HP:0012240)2.72730797
34Progressive macrocephaly (HP:0004481)2.71000860
35Impaired platelet aggregation (HP:0003540)2.70211919
36Abnormal platelet function (HP:0011869)2.70211919
37Nasal polyposis (HP:0100582)2.69173899
38Tubulointerstitial nephritis (HP:0001970)2.66726991
39Type I transferrin isoform profile (HP:0003642)2.66144349
40Hepatic necrosis (HP:0002605)2.64421484
41Cholelithiasis (HP:0001081)2.63918997
42Recurrent abscess formation (HP:0002722)2.63442363
43Nausea (HP:0002018)2.62820880
44Abnormal protein glycosylation (HP:0012346)2.62324738
45Abnormal glycosylation (HP:0012345)2.62324738
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62324738
47Abnormal protein N-linked glycosylation (HP:0012347)2.62324738
48Abnormality of fatty-acid metabolism (HP:0004359)2.60388202
49Hyperthyroidism (HP:0000836)2.59517749
50Reticulocytopenia (HP:0001896)2.58893416
51Increased CSF lactate (HP:0002490)2.58864236
52Aplastic anemia (HP:0001915)2.56887453
53Renal Fanconi syndrome (HP:0001994)2.54286477
54Rimmed vacuoles (HP:0003805)2.53155207
55Renal cortical cysts (HP:0000803)2.47000140
56Increased serum ferritin (HP:0003281)2.46196443
57Exercise-induced muscle cramps (HP:0003710)2.45856642
58Recurrent bacterial skin infections (HP:0005406)2.43730360
59Abnormality of the nasal mucosa (HP:0000433)2.43371052
60Abnormal rod and cone electroretinograms (HP:0008323)2.41395684
61Abnormal gallbladder physiology (HP:0012438)2.41114015
62Cholecystitis (HP:0001082)2.41114015
63Visual hallucinations (HP:0002367)2.41079223
64Orchitis (HP:0100796)2.39902827
65Abnormality of reticulocytes (HP:0004312)2.39714968
66Chronic otitis media (HP:0000389)2.38949491
67Type 2 muscle fiber atrophy (HP:0003554)2.38398455
68Cerebral edema (HP:0002181)2.35994827
69Ragged-red muscle fibers (HP:0003200)2.35950299
70Gingival bleeding (HP:0000225)2.35670662
71Abnormality of iron homeostasis (HP:0011031)2.33818495
72Hepatocellular necrosis (HP:0001404)2.31655755
73Abnormality of lateral ventricle (HP:0030047)2.30809823
74Abnormality of T cell physiology (HP:0011840)2.29056084
75Reticulocytosis (HP:0001923)2.28927092
76Hyperammonemia (HP:0001987)2.27018227
77Muscle fiber atrophy (HP:0100295)2.26893167
78Generalized aminoaciduria (HP:0002909)2.24276570
79Exercise intolerance (HP:0003546)2.24113416
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22940743
81Lactic acidosis (HP:0003128)2.21106788
82Hyperglycinemia (HP:0002154)2.19668251
83Ventricular fibrillation (HP:0001663)2.19637660
84Microcytic anemia (HP:0001935)2.18548215
85Poikiloderma (HP:0001029)2.17664060
86Retrobulbar optic neuritis (HP:0100654)2.17159348
87Optic neuritis (HP:0100653)2.17159348
88Pendular nystagmus (HP:0012043)2.16481841
89Muscle hypertrophy of the lower extremities (HP:0008968)2.16231406
90Recurrent bronchitis (HP:0002837)2.14608620
91Hypoglycemic coma (HP:0001325)2.11270600
92Abnormality of transition element cation homeostasis (HP:0011030)2.10492442
93Neurodegeneration (HP:0002180)2.10255933
94Pallor (HP:0000980)2.09807835
95Hypoplasia of the thymus (HP:0000778)2.03507883
96Recurrent viral infections (HP:0004429)2.03394330
973-Methylglutaconic aciduria (HP:0003535)2.01261264
98Abnormality of renal resorption (HP:0011038)2.00755559
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.98855950
100Amaurosis fugax (HP:0100576)1.96928660
101Muscle stiffness (HP:0003552)1.96622772
102Metabolic acidosis (HP:0001942)1.93827299
103Polycythemia (HP:0001901)1.93395848
104Sudden death (HP:0001699)1.93268370
105Abnormality of the gallbladder (HP:0005264)1.92355252
106Abnormal pupillary function (HP:0007686)1.92148852
107Calf muscle hypertrophy (HP:0008981)1.91199024
108Abnormality of the intrinsic pathway (HP:0010989)1.90686685
109Inflammation of the large intestine (HP:0002037)1.89427398
110Respiratory failure (HP:0002878)1.89209343
111Recurrent skin infections (HP:0001581)1.88641081
112Microvesicular hepatic steatosis (HP:0001414)1.88467139
113Pancytopenia (HP:0001876)1.88026448
114Gastrointestinal inflammation (HP:0004386)1.87995739
115Myelodysplasia (HP:0002863)1.85609321
116Abnormal spermatogenesis (HP:0008669)1.85469656
117Abnormality of T cells (HP:0002843)1.84656393
118Increased muscle lipid content (HP:0009058)1.84495078
119Acute myeloid leukemia (HP:0004808)1.83782680
120Neutropenia (HP:0001875)1.82918385
121Meningitis (HP:0001287)1.82174974
122Hypochromic anemia (HP:0001931)1.80671964
123Hyperglycinuria (HP:0003108)1.80505474
124Polyneuropathy (HP:0001271)1.80270436
125EMG: neuropathic changes (HP:0003445)1.80032247
126Arterial thrombosis (HP:0004420)1.79858061
127Muscle fiber splitting (HP:0003555)1.79650868
128Lethargy (HP:0001254)1.79635836
129Abnormality of B cell number (HP:0010975)1.79571118
130B lymphocytopenia (HP:0010976)1.79571118
131Basal ganglia calcification (HP:0002135)1.79542435
132Hypertriglyceridemia (HP:0002155)1.78065108
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77928515
134Periodontitis (HP:0000704)1.77706978
135Rhabdomyolysis (HP:0003201)1.77544395
136Macrocytic anemia (HP:0001972)1.76177552
137Cutaneous photosensitivity (HP:0000992)1.75814912
138Areflexia of lower limbs (HP:0002522)1.75416002
139Encephalitis (HP:0002383)1.75109275
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75031157
141Dicarboxylic aciduria (HP:0003215)1.75031157
142Abnormality of the prostate (HP:0008775)1.73869160
143Exertional dyspnea (HP:0002875)1.73864694
144Hyperlipoproteinemia (HP:0010980)1.73531907
14511 pairs of ribs (HP:0000878)1.73392934
146Abnormality of urine glucose concentration (HP:0011016)1.73237373
147Glycosuria (HP:0003076)1.73237373
148Autoimmune thrombocytopenia (HP:0001973)1.73209812
149Abnormal gallbladder morphology (HP:0012437)1.73186379
150Distal arthrogryposis (HP:0005684)1.72761984
151Fatigue (HP:0012378)1.72343036
152Tinnitus (HP:0000360)1.71989815
153Eczematoid dermatitis (HP:0000976)1.71752619
154Nonimmune hydrops fetalis (HP:0001790)1.71614962
155Thrombophlebitis (HP:0004418)1.71574113
156Progressive muscle weakness (HP:0003323)1.70948234
157Purpura (HP:0000979)1.70933351
158Hepatosplenomegaly (HP:0001433)1.70698324
159EMG: myopathic abnormalities (HP:0003458)1.70288280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.87600010
2VRK23.59141841
3NUAK12.68104764
4SRPK12.67508320
5IRAK32.64840134
6MAP4K22.62631491
7NME22.52425436
8TEC2.37261468
9PHKG12.29981283
10PHKG22.29981283
11FLT32.28133491
12BLK2.22850407
13TBK12.13956921
14MAP4K12.07992277
15KIT1.95716767
16MUSK1.95246371
17MAP3K141.92994021
18MST41.91528326
19TYK21.88958034
20TAOK31.82075888
21BCKDK1.82074435
22STK161.76234308
23MAP2K31.72737487
24NEK11.72341557
25IRAK41.71531214
26EIF2AK11.68472942
27BTK1.68223144
28JAK31.67592545
29ZAP701.63901454
30EEF2K1.63849359
31PKN21.59931073
32PIM21.58973396
33IKBKE1.57037436
34ARAF1.50728365
35INSRR1.48624827
36ACVR1B1.47044909
37CDC71.43942354
38ZAK1.38741461
39WEE11.35323546
40IKBKB1.34850912
41ERN11.33200384
42PDK31.32592862
43PDK41.32592862
44BRSK21.31574277
45RAF11.31028463
46TNK21.29667597
47PLK41.23499261
48NEK21.22647498
49TGFBR11.20367482
50SYK1.16592946
51RPS6KA41.16454159
52MAPK121.13079676
53TXK1.12816482
54EIF2AK21.12286606
55BMX1.11201407
56DYRK31.10800601
57BUB11.10494003
58MAP2K41.09422855
59PIM11.08950668
60VRK11.08865977
61CSF1R1.05746868
62EIF2AK31.04893648
63TGFBR21.03569648
64MAP3K11.01876418
65ABL21.00799208
66PNCK0.99012078
67ATR0.98405045
68DAPK30.96763845
69JAK10.94715505
70NEK90.92008134
71STK100.91798711
72STK40.89909998
73PKN10.89445741
74CDK70.89214490
75STK240.89148307
76MAP3K60.86671367
77FES0.86514071
78RIPK40.85912601
79MAPK130.84424138
80TRPM70.84205360
81MAP2K60.81809431
82LYN0.81186890
83KDR0.81076598
84MATK0.80526555
85JAK20.78706337
86IRAK10.77865419
87DAPK20.75609045
88PASK0.74743367
89PRKG20.73514567
90MAPKAPK30.72896796
91LRRK20.72834591
92CDK80.72032747
93MAP2K70.71970523
94MAPK110.71901974
95MAP3K130.71887103
96CHUK0.70410583
97BRSK10.69092088
98CDK40.69081313
99TAF10.67400659
100MAP3K50.66832410
101RPS6KA50.66367466
102CAMKK20.66201559
103TRIB30.64904174
104TIE10.64130520
105MAP3K70.61966762
106TAOK20.60938812
107PIK3CG0.60631402
108TLK10.59825561
109LCK0.59225265
110PRKAA20.58875028
111TESK10.57023526
112FRK0.56484704
113CCNB10.56260869
114FGFR40.56148159
115TESK20.55612544
116CDK190.54861171
117RPS6KA60.52805530
118DYRK20.52051032
119AURKB0.51571696
120AURKA0.51454559
121MAP3K110.51175675
122SCYL20.50940834
123ITK0.50310463
124PRKCQ0.50245669
125MAP3K100.48339660
126PTK2B0.48103971
127WNK30.47886805
128TTK0.47527607
129MAP3K30.46789907
130HIPK20.46519651
131DYRK1B0.45432604
132RPS6KB20.44877118
133NME10.43153972
134CDK60.42763061
135PRKG10.41522596
136BRAF0.41154214
137TAOK10.40011370
138PRKACA0.38774559
139DAPK10.38583700
140MAPK30.37926962
141TTN0.37718860
142PBK0.37117631
143MAPK40.36912664
144RPS6KC10.36618940
145RPS6KL10.36618940
146CSNK2A20.36163314
147CAMK2G0.35320993
148HCK0.35208841
149PRKACG0.34491357
150PAK10.34379491
151MAP3K80.34146857
152ATM0.34018390
153MARK30.33867077
154MINK10.32536113
155CAMK10.32040778
156ILK0.30331977
157MAPKAPK50.30187646

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73850673
2Fatty acid elongation_Homo sapiens_hsa000623.49197836
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.23493467
4Parkinsons disease_Homo sapiens_hsa050122.94298003
5Oxidative phosphorylation_Homo sapiens_hsa001902.83773210
6Nitrogen metabolism_Homo sapiens_hsa009102.69622118
7Ribosome_Homo sapiens_hsa030102.53022517
8Homologous recombination_Homo sapiens_hsa034402.23706466
9Base excision repair_Homo sapiens_hsa034102.23027278
10Selenocompound metabolism_Homo sapiens_hsa004502.14725107
11Mismatch repair_Homo sapiens_hsa034301.98914381
12Folate biosynthesis_Homo sapiens_hsa007901.90686495
13Platelet activation_Homo sapiens_hsa046111.88503655
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87544488
15Fatty acid degradation_Homo sapiens_hsa000711.85125256
16Pyrimidine metabolism_Homo sapiens_hsa002401.69021136
17Cardiac muscle contraction_Homo sapiens_hsa042601.64216244
18Alzheimers disease_Homo sapiens_hsa050101.57958896
19Huntingtons disease_Homo sapiens_hsa050161.57531907
20Butanoate metabolism_Homo sapiens_hsa006501.56782305
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55625894
22One carbon pool by folate_Homo sapiens_hsa006701.54351642
23Non-homologous end-joining_Homo sapiens_hsa034501.48775851
24Propanoate metabolism_Homo sapiens_hsa006401.46371642
25Herpes simplex infection_Homo sapiens_hsa051681.43891596
26Sulfur relay system_Homo sapiens_hsa041221.43193206
27Nucleotide excision repair_Homo sapiens_hsa034201.42576050
28Pentose phosphate pathway_Homo sapiens_hsa000301.41986218
29Regulation of autophagy_Homo sapiens_hsa041401.40720982
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.40254090
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38502650
32Measles_Homo sapiens_hsa051621.38265511
33Leishmaniasis_Homo sapiens_hsa051401.35540632
34Arachidonic acid metabolism_Homo sapiens_hsa005901.35286756
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33900361
36ABC transporters_Homo sapiens_hsa020101.33122116
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29515875
38* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27754417
39Legionellosis_Homo sapiens_hsa051341.27705474
40Caffeine metabolism_Homo sapiens_hsa002321.26928111
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.26479164
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22747360
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20754501
44Tryptophan metabolism_Homo sapiens_hsa003801.20313589
45Hematopoietic cell lineage_Homo sapiens_hsa046401.19019891
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18887064
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18461767
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.18397628
49Peroxisome_Homo sapiens_hsa041461.18338555
50N-Glycan biosynthesis_Homo sapiens_hsa005101.18200634
51beta-Alanine metabolism_Homo sapiens_hsa004101.17228795
52Protein export_Homo sapiens_hsa030601.12180464
53Primary immunodeficiency_Homo sapiens_hsa053401.12149377
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09590009
55Vitamin B6 metabolism_Homo sapiens_hsa007501.08545421
56Tyrosine metabolism_Homo sapiens_hsa003501.07773634
57Pyruvate metabolism_Homo sapiens_hsa006201.07375204
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07067042
59Arginine biosynthesis_Homo sapiens_hsa002201.04101644
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.04045013
61Collecting duct acid secretion_Homo sapiens_hsa049661.04014855
62Fanconi anemia pathway_Homo sapiens_hsa034601.02852808
63RNA degradation_Homo sapiens_hsa030181.01803231
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.01451508
65Purine metabolism_Homo sapiens_hsa002301.00028392
66Cell cycle_Homo sapiens_hsa041100.98048483
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.97028880
68Other glycan degradation_Homo sapiens_hsa005110.96290747
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93233511
70Starch and sucrose metabolism_Homo sapiens_hsa005000.91968996
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89514224
72Phenylalanine metabolism_Homo sapiens_hsa003600.88670966
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.88294198
74B cell receptor signaling pathway_Homo sapiens_hsa046620.87716433
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.86267276
76Carbon metabolism_Homo sapiens_hsa012000.85977262
77Circadian rhythm_Homo sapiens_hsa047100.84873749
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.84129839
79Galactose metabolism_Homo sapiens_hsa000520.84047894
80Proteasome_Homo sapiens_hsa030500.83095913
81Histidine metabolism_Homo sapiens_hsa003400.81882853
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81486368
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81340301
84Antigen processing and presentation_Homo sapiens_hsa046120.81221537
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79493705
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79472881
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.78557800
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76858523
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75751522
90Osteoclast differentiation_Homo sapiens_hsa043800.75036613
91Glutathione metabolism_Homo sapiens_hsa004800.73207698
92Systemic lupus erythematosus_Homo sapiens_hsa053220.73190847
93Oocyte meiosis_Homo sapiens_hsa041140.72475522
94Olfactory transduction_Homo sapiens_hsa047400.72221808
95p53 signaling pathway_Homo sapiens_hsa041150.71706832
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70776085
97Apoptosis_Homo sapiens_hsa042100.70562374
98Influenza A_Homo sapiens_hsa051640.70334434
99Spliceosome_Homo sapiens_hsa030400.69352878
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68949871
101Biosynthesis of amino acids_Homo sapiens_hsa012300.66936859
102RNA polymerase_Homo sapiens_hsa030200.66482682
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65927963
104Basal transcription factors_Homo sapiens_hsa030220.65498209
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64480868
106Acute myeloid leukemia_Homo sapiens_hsa052210.63952863
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63293646
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63248829
109Linoleic acid metabolism_Homo sapiens_hsa005910.62435403
110Toxoplasmosis_Homo sapiens_hsa051450.59908702
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58708862
112Staphylococcus aureus infection_Homo sapiens_hsa051500.57999852
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57696347
114Arginine and proline metabolism_Homo sapiens_hsa003300.57693760
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57574070
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.56416548
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55978781
118RNA transport_Homo sapiens_hsa030130.55133555
119TNF signaling pathway_Homo sapiens_hsa046680.54370497
120Chemical carcinogenesis_Homo sapiens_hsa052040.53935285
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53021336
122* Metabolic pathways_Homo sapiens_hsa011000.52850199
123Fatty acid metabolism_Homo sapiens_hsa012120.51788177
124Pertussis_Homo sapiens_hsa051330.51613529
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51498206
126Lysine degradation_Homo sapiens_hsa003100.51323521
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51312956
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51030313
129PPAR signaling pathway_Homo sapiens_hsa033200.50253045
130Epstein-Barr virus infection_Homo sapiens_hsa051690.49964405
131Fructose and mannose metabolism_Homo sapiens_hsa000510.49520693
132Small cell lung cancer_Homo sapiens_hsa052220.47036182
133Renin-angiotensin system_Homo sapiens_hsa046140.46585472
134Calcium signaling pathway_Homo sapiens_hsa040200.46578808
135Sulfur metabolism_Homo sapiens_hsa009200.46569245
136Phototransduction_Homo sapiens_hsa047440.42620315
137Alcoholism_Homo sapiens_hsa050340.39884317
138Dilated cardiomyopathy_Homo sapiens_hsa054140.38385372
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.30729719
140Pancreatic secretion_Homo sapiens_hsa049720.29673676
141Malaria_Homo sapiens_hsa051440.29412217
142Glycerolipid metabolism_Homo sapiens_hsa005610.29151412
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27194986
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27125896
145Inositol phosphate metabolism_Homo sapiens_hsa005620.25585233
146Retinol metabolism_Homo sapiens_hsa008300.23930298

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