NMRAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.03609876
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.29779290
3ensheathment of neurons (GO:0007272)5.12392481
4axon ensheathment (GO:0008366)5.12392481
5myelination (GO:0042552)5.12381509
6long-chain fatty acid biosynthetic process (GO:0042759)4.64044421
7myelin maintenance (GO:0043217)4.55839755
8positive regulation of oligodendrocyte differentiation (GO:0048714)4.43529113
9regulation of mitochondrial translation (GO:0070129)4.40877275
10DNA strand elongation involved in DNA replication (GO:0006271)4.37064301
11telomere maintenance via semi-conservative replication (GO:0032201)4.27919522
12pyrimidine nucleotide catabolic process (GO:0006244)4.25298511
13protein neddylation (GO:0045116)4.23756137
14deoxyribonucleotide catabolic process (GO:0009264)4.19550779
15DNA strand elongation (GO:0022616)4.18808139
16chaperone-mediated protein transport (GO:0072321)4.16135832
17base-excision repair, AP site formation (GO:0006285)4.14466891
18pseudouridine synthesis (GO:0001522)4.11782511
19deoxyribose phosphate catabolic process (GO:0046386)4.06648254
20GPI anchor biosynthetic process (GO:0006506)4.05748295
21pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.02761731
22microtubule polymerization or depolymerization (GO:0031109)3.92445151
23DNA unwinding involved in DNA replication (GO:0006268)3.92351715
24regulation of cellular amino acid metabolic process (GO:0006521)3.92336910
25establishment of integrated proviral latency (GO:0075713)3.86331695
26cholesterol biosynthetic process (GO:0006695)3.78564901
27rRNA modification (GO:0000154)3.77072265
28translational elongation (GO:0006414)3.76311596
29GDP-mannose metabolic process (GO:0019673)3.70762581
30purine deoxyribonucleotide catabolic process (GO:0009155)3.66288315
31telomere maintenance via recombination (GO:0000722)3.66001535
32DNA ligation (GO:0006266)3.65289737
33oligodendrocyte differentiation (GO:0048709)3.64237074
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63647803
35GPI anchor metabolic process (GO:0006505)3.62995532
36negative regulation of B cell apoptotic process (GO:0002903)3.60843649
37ribonucleoprotein complex biogenesis (GO:0022613)3.59800060
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.57327797
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54794669
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.53619761
41establishment of mitochondrion localization (GO:0051654)3.53545206
42DNA replication initiation (GO:0006270)3.53214795
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51331553
44protein maturation by protein folding (GO:0022417)3.51117211
45formation of translation preinitiation complex (GO:0001731)3.49804941
46cytochrome complex assembly (GO:0017004)3.49497811
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49203941
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49203941
49ribosomal small subunit biogenesis (GO:0042274)3.49003003
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47923457
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47923457
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47923457
53mitotic recombination (GO:0006312)3.45326883
54respiratory chain complex IV assembly (GO:0008535)3.43053682
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.40649098
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40649098
57viral life cycle (GO:0019058)3.39893390
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37925492
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37653377
60deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.37502368
61preassembly of GPI anchor in ER membrane (GO:0016254)3.36356464
62translational initiation (GO:0006413)3.35419530
63isoprenoid biosynthetic process (GO:0008299)3.32910701
64establishment of viral latency (GO:0019043)3.32564241
65ATP synthesis coupled proton transport (GO:0015986)3.32056762
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32056762
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.31203073
682-deoxyribonucleotide metabolic process (GO:0009394)3.30335293
69sterol biosynthetic process (GO:0016126)3.29987888
70cellular component biogenesis (GO:0044085)3.29845519
71ribosome biogenesis (GO:0042254)3.28652694
72mannosylation (GO:0097502)3.28501836
73apical protein localization (GO:0045176)3.27295511
74termination of RNA polymerase III transcription (GO:0006386)3.25872825
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.25872825
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25018923
77proteasome assembly (GO:0043248)3.23466789
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21148335
79viral transcription (GO:0019083)3.20021962
80deoxyribose phosphate biosynthetic process (GO:0046385)3.19184153
812-deoxyribonucleotide biosynthetic process (GO:0009265)3.19184153
82negative regulation of protein localization to cell surface (GO:2000009)3.18683704
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18403314
84cotranslational protein targeting to membrane (GO:0006613)3.17097764
85viral mRNA export from host cell nucleus (GO:0046784)3.16972946
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15442934
87deoxyribose phosphate metabolic process (GO:0019692)3.15200360
88astrocyte development (GO:0014002)3.14555807
89purine nucleobase biosynthetic process (GO:0009113)3.12872548
90translation (GO:0006412)3.12578870
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11919075
92protein complex biogenesis (GO:0070271)3.11139402
93translational termination (GO:0006415)3.09362697
94response to interferon-beta (GO:0035456)3.09031703
95purine nucleotide salvage (GO:0032261)3.07827833
96cellular protein complex disassembly (GO:0043624)3.07743158
97protein targeting to ER (GO:0045047)3.07193976
98telomere maintenance via telomere lengthening (GO:0010833)3.06803954
99nucleotide salvage (GO:0043173)3.03932694
100L-serine metabolic process (GO:0006563)3.03234852
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02920803
102regulation of collateral sprouting (GO:0048670)3.01474299
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99757231
104maturation of SSU-rRNA (GO:0030490)2.98668355
105protein localization to endoplasmic reticulum (GO:0070972)2.97405851
106rRNA processing (GO:0006364)2.96845885
107negative regulation of neurotransmitter secretion (GO:0046929)2.96040150
108mitochondrial respiratory chain complex assembly (GO:0033108)2.95763366
109amyloid precursor protein metabolic process (GO:0042982)2.95456599
110transcription-coupled nucleotide-excision repair (GO:0006283)2.95083809
111nucleobase biosynthetic process (GO:0046112)2.95055415
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95028292
113positive regulation of ligase activity (GO:0051351)2.94861710
114metallo-sulfur cluster assembly (GO:0031163)2.93392372
115iron-sulfur cluster assembly (GO:0016226)2.93392372
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92034518
117regulation of cellular amine metabolic process (GO:0033238)2.91665946
118asymmetric protein localization (GO:0008105)2.90638815
119DNA replication checkpoint (GO:0000076)2.89054796
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88893633
121deoxyribonucleotide metabolic process (GO:0009262)2.88740675
122positive regulation of cell cycle checkpoint (GO:1901978)2.88383555
123inner mitochondrial membrane organization (GO:0007007)2.88275841
124nucleoside transmembrane transport (GO:1901642)2.88260977
125respiratory electron transport chain (GO:0022904)2.87487926
126ribosomal small subunit assembly (GO:0000028)2.87230667
127electron transport chain (GO:0022900)2.87019451
128spliceosomal complex assembly (GO:0000245)2.85623447
129base-excision repair (GO:0006284)2.85425171
130CENP-A containing nucleosome assembly (GO:0034080)2.84060270
131negative regulation of neurotransmitter transport (GO:0051589)2.83541390
132centriole replication (GO:0007099)2.82923374
133substantia nigra development (GO:0021762)2.81014569
134glycerophospholipid catabolic process (GO:0046475)2.80661363
135DNA deamination (GO:0045006)2.80292889
136rRNA metabolic process (GO:0016072)2.79820260
137protein complex disassembly (GO:0043241)2.78992722
138pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77108348
139glial cell development (GO:0021782)2.75853023
140creatine metabolic process (GO:0006600)2.75199015
141exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74663534
142negative regulation of execution phase of apoptosis (GO:1900118)2.72441510
143negative regulation of ligase activity (GO:0051352)2.71483746
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71483746
145photoreceptor cell differentiation (GO:0046530)2.71228858
146eye photoreceptor cell differentiation (GO:0001754)2.71228858
1477-methylguanosine RNA capping (GO:0009452)2.70375403
148RNA capping (GO:0036260)2.70375403
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68265477
150ribosomal large subunit biogenesis (GO:0042273)2.67540746
1517-methylguanosine mRNA capping (GO:0006370)2.67453502
152negative regulation of chemokine production (GO:0032682)2.67100003
153C-terminal protein lipidation (GO:0006501)2.65718753
154response to methylmercury (GO:0051597)2.65404438
155spliceosomal snRNP assembly (GO:0000387)2.65047124
156limb bud formation (GO:0060174)2.64718923
157mitotic nuclear envelope reassembly (GO:0007084)2.64659231
158nuclear envelope reassembly (GO:0031468)2.64659231
159chromatin remodeling at centromere (GO:0031055)2.62754055
160nucleotide transmembrane transport (GO:1901679)2.62705902
161mismatch repair (GO:0006298)2.62574762
162positive regulation of cellular amine metabolic process (GO:0033240)2.62356841
163response to lead ion (GO:0010288)2.62326260
164DNA replication-dependent nucleosome assembly (GO:0006335)2.60967187
165DNA replication-dependent nucleosome organization (GO:0034723)2.60967187
166L-methionine biosynthetic process (GO:0071265)2.59376038
167amino acid salvage (GO:0043102)2.59376038
168L-methionine salvage (GO:0071267)2.59376038
169signal peptide processing (GO:0006465)2.58526485
170axon ensheathment in central nervous system (GO:0032291)10.2434050
171central nervous system myelination (GO:0022010)10.2434050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.12928374
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.83379255
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43274812
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.03689284
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.67730128
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.58885088
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43241469
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.31381983
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.12880749
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11288605
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10484430
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10369320
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09316298
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07370755
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.89354420
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88691088
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87403255
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75556477
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71086976
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43015521
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40829158
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38119652
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31941366
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27558195
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27208862
26XRN2_22483619_ChIP-Seq_HELA_Human2.13649794
27VDR_23849224_ChIP-Seq_CD4+_Human2.12485532
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03572679
29VDR_21846776_ChIP-Seq_THP-1_Human1.99644575
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99183866
31* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90058961
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.82999687
33FOXP3_21729870_ChIP-Seq_TREG_Human1.82359636
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80135896
35IRF1_19129219_ChIP-ChIP_H3396_Human1.78939019
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73946259
37TTF2_22483619_ChIP-Seq_HELA_Human1.72972844
38DCP1A_22483619_ChIP-Seq_HELA_Human1.71580546
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69756757
40MYC_22102868_ChIP-Seq_BL_Human1.65281792
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63655611
42ELK1_19687146_ChIP-ChIP_HELA_Human1.58509759
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.58110281
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56235529
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54692314
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.54411732
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54146156
48AR_21909140_ChIP-Seq_LNCAP_Human1.53618218
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51569699
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51116245
51GABP_19822575_ChIP-Seq_HepG2_Human1.51061644
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48233776
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45171167
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43959138
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43934907
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.42266783
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41091656
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.38709015
59P68_20966046_ChIP-Seq_HELA_Human1.38555808
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37891075
61ZNF263_19887448_ChIP-Seq_K562_Human1.34946732
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33456686
63LXR_22292898_ChIP-Seq_THP-1_Human1.32772053
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.32184086
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31409071
66MYC_18940864_ChIP-ChIP_HL60_Human1.30078584
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27081446
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.26911913
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25578820
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25490330
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25119125
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23586641
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22418272
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21720414
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20310269
76* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19083714
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18971418
78BCOR_27268052_Chip-Seq_Bcells_Human1.18966420
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18923487
80BCL6_27268052_Chip-Seq_Bcells_Human1.17986999
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16571786
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15248053
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15174629
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14450097
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12895402
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12822590
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12593925
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11628943
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09918933
90PHF8_20622854_ChIP-Seq_HELA_Human1.09883351
91MAF_26560356_Chip-Seq_TH2_Human1.09579039
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.08674713
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.07921583
94E2F1_20622854_ChIP-Seq_HELA_Human1.06063978
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.04140300
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03099857
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.02287623
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00734712
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96603417
100UTX_26944678_Chip-Seq_JUKART_Human0.96498592
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96242002
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95993245
103E2F1_21310950_ChIP-Seq_MCF-7_Human0.95949657
104VDR_24763502_ChIP-Seq_THP-1_Human0.95708990
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95004858
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94372017
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94074502
108ATF3_27146783_Chip-Seq_COLON_Human0.93579008
109CIITA_25753668_ChIP-Seq_RAJI_Human0.93547006
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93482744
111EWS_26573619_Chip-Seq_HEK293_Human0.91910861
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91840940
113FUS_26573619_Chip-Seq_HEK293_Human0.91653410
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91076260
115* KDM5A_27292631_Chip-Seq_BREAST_Human0.90010914
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89102196
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88888664
118STAT1_20625510_ChIP-Seq_HELA_Human0.88759237
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.82004739
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81920626
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80706518
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78115039
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77920418
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77339280
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.74141102
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.73743208
127TAF15_26573619_Chip-Seq_HEK293_Human0.73398504
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.72902257
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71239658
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69348761
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68184765
132TFEB_21752829_ChIP-Seq_HELA_Human0.66733642
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65722379
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.65274459
135VDR_22108803_ChIP-Seq_LS180_Human0.63439701
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62474720
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62123547
138* EOMES_21245162_ChIP-Seq_HESCs_Human0.61445831
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.59844867
140ER_23166858_ChIP-Seq_MCF-7_Human0.59323694
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.59165596
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.57915744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.80315653
2MP0001529_abnormal_vocalization3.60345772
3MP0003950_abnormal_plasma_membrane3.52445683
4MP0008057_abnormal_DNA_replication3.28229625
5MP0003136_yellow_coat_color2.73262770
6MP0001905_abnormal_dopamine_level2.66022535
7MP0010094_abnormal_chromosome_stability2.43976258
8MP0005171_absent_coat_pigmentation2.43851585
9MP0008875_abnormal_xenobiotic_pharmacok2.43198350
10MP0005409_darkened_coat_color2.37089668
11MP0000566_synostosis2.32663647
12MP0003806_abnormal_nucleotide_metabolis2.31203297
13MP0008932_abnormal_embryonic_tissue2.25765388
14MP0002938_white_spotting2.25159633
15MP0003786_premature_aging2.24388130
16MP0005360_urolithiasis2.18624687
17MP0006036_abnormal_mitochondrial_physio2.10830449
18MP0004147_increased_porphyrin_level2.04648303
19MP0003880_abnormal_central_pattern2.02693684
20MP0006035_abnormal_mitochondrial_morpho1.95513120
21MP0003077_abnormal_cell_cycle1.91836547
22MP0009697_abnormal_copulation1.91811589
23MP0004142_abnormal_muscle_tone1.90886658
24MP0006292_abnormal_olfactory_placode1.89553436
25MP0002796_impaired_skin_barrier1.86918527
26MP0004381_abnormal_hair_follicle1.82139179
27MP0001485_abnormal_pinna_reflex1.82135497
28MP0005501_abnormal_skin_physiology1.81973187
29MP0005083_abnormal_biliary_tract1.81666906
30MP0004742_abnormal_vestibular_system1.79747548
31MP0008058_abnormal_DNA_repair1.78386505
32MP0004134_abnormal_chest_morphology1.77974664
33MP0002254_reproductive_system_inflammat1.76847961
34MP0009278_abnormal_bone_marrow1.75382216
35MP0003690_abnormal_glial_cell1.74906033
36MP0004957_abnormal_blastocyst_morpholog1.70046275
37MP0001881_abnormal_mammary_gland1.66020473
38MP0003938_abnormal_ear_development1.65574150
39MP0004133_heterotaxia1.63233048
40MP0000490_abnormal_crypts_of1.62956763
41MP0001873_stomach_inflammation1.62602317
42MP0000383_abnormal_hair_follicle1.61017847
43MP0003634_abnormal_glial_cell1.58085202
44MP0002019_abnormal_tumor_incidence1.57488140
45MP0001853_heart_inflammation1.55631026
46MP0003937_abnormal_limbs/digits/tail_de1.55159472
47MP0000358_abnormal_cell_content/1.55108681
48MP0005410_abnormal_fertilization1.52333350
49MP0001764_abnormal_homeostasis1.51743490
50MP0003111_abnormal_nucleus_morphology1.48488145
51MP0002132_abnormal_respiratory_system1.46656199
52MP0000778_abnormal_nervous_system1.44228925
53MP0002102_abnormal_ear_morphology1.41549160
54MP0001293_anophthalmia1.35706852
55MP0008260_abnormal_autophagy1.35541375
56MP0001835_abnormal_antigen_presentation1.35065192
57MP0002272_abnormal_nervous_system1.34522938
58MP0002148_abnormal_hypersensitivity_rea1.34503170
59MP0000462_abnormal_digestive_system1.32185335
60MP0002229_neurodegeneration1.31216679
61MP0004185_abnormal_adipocyte_glucose1.30070944
62MP0003011_delayed_dark_adaptation1.28227667
63MP0010030_abnormal_orbit_morphology1.28157610
64MP0004885_abnormal_endolymph1.28125831
65MP0010386_abnormal_urinary_bladder1.25091363
66MP0003632_abnormal_nervous_system1.23501280
67MP0005451_abnormal_body_composition1.22898608
68MP0005075_abnormal_melanosome_morpholog1.22105511
69MP0008877_abnormal_DNA_methylation1.20880231
70MP0008873_increased_physiological_sensi1.19793343
71MP0003866_abnormal_defecation1.19517190
72MP0005058_abnormal_lysosome_morphology1.18875633
73MP0002751_abnormal_autonomic_nervous1.18463726
74MP0003656_abnormal_erythrocyte_physiolo1.18190727
75MP0002736_abnormal_nociception_after1.17724199
76MP0003763_abnormal_thymus_physiology1.17101352
77MP0000631_abnormal_neuroendocrine_gland1.16004611
78MP0003693_abnormal_embryo_hatching1.15828435
79MP0008789_abnormal_olfactory_epithelium1.15495839
80MP0005397_hematopoietic_system_phenotyp1.15382738
81MP0001545_abnormal_hematopoietic_system1.15382738
82MP0005025_abnormal_response_to1.15120468
83MP0004019_abnormal_vitamin_homeostasis1.14911158
84MP0008469_abnormal_protein_level1.13653175
85MP0009643_abnormal_urine_homeostasis1.13188544
86MP0005423_abnormal_somatic_nervous1.12648082
87MP0010678_abnormal_skin_adnexa1.11896170
88MP0001486_abnormal_startle_reflex1.11846076
89MP0004270_analgesia1.11004094
90MP0000313_abnormal_cell_death1.10358789
91MP0003638_abnormal_response/metabolism_1.10145531
92MP0000049_abnormal_middle_ear1.08265855
93MP0005408_hypopigmentation1.07928064
94MP0005636_abnormal_mineral_homeostasis1.06846134
95MP0008007_abnormal_cellular_replicative1.06727896
96MP0000685_abnormal_immune_system1.06373015
97MP0005332_abnormal_amino_acid1.06307495
98MP0008872_abnormal_physiological_respon1.06141313
99MP0009785_altered_susceptibility_to1.05362549
100MP0000538_abnormal_urinary_bladder1.04474891
101MP0003191_abnormal_cellular_cholesterol1.03843784
102MP0002752_abnormal_somatic_nervous1.03719595
103MP0001968_abnormal_touch/_nociception1.03543769
104MP0000762_abnormal_tongue_morphology1.01508241
105MP0003436_decreased_susceptibility_to1.01016877
106MP0004043_abnormal_pH_regulation0.99631872
107MP0002722_abnormal_immune_system0.99538800
108MP0002398_abnormal_bone_marrow0.99404027
109MP0005319_abnormal_enzyme/_coenzyme0.99234836
110MP0010771_integument_phenotype0.99217895
111MP0004808_abnormal_hematopoietic_stem0.98900165
112MP0002429_abnormal_blood_cell0.98826060
113MP0001346_abnormal_lacrimal_gland0.98565474
114MP0009840_abnormal_foam_cell0.98435658
115MP0000689_abnormal_spleen_morphology0.97431690
116MP0002160_abnormal_reproductive_system0.96588771
117MP0001963_abnormal_hearing_physiology0.93740246
118MP0009379_abnormal_foot_pigmentation0.93313165
119MP0000627_abnormal_mammary_gland0.93309173
120MP0002277_abnormal_respiratory_mucosa0.92566889
121MP0005195_abnormal_posterior_eye0.92158773
122MP0001730_embryonic_growth_arrest0.92090624
123MP0010234_abnormal_vibrissa_follicle0.91950571
124MP0000026_abnormal_inner_ear0.90745184
125MP0006072_abnormal_retinal_apoptosis0.90126448
126MP0001986_abnormal_taste_sensitivity0.89757432
127MP0001819_abnormal_immune_cell0.89418232
128MP0002420_abnormal_adaptive_immunity0.88735118
129MP0000703_abnormal_thymus_morphology0.87014138
130MP0003315_abnormal_perineum_morphology0.86992355
131MP0001216_abnormal_epidermal_layer0.86912751
132MP0005000_abnormal_immune_tolerance0.85686371
133MP0003861_abnormal_nervous_system0.85405411
134MP0003718_maternal_effect0.85316416
135MP0000465_gastrointestinal_hemorrhage0.84872326
136MP0002882_abnormal_neuron_morphology0.83747775
137MP0003186_abnormal_redox_activity0.83147242
138MP0002080_prenatal_lethality0.82060575
139MP0009250_abnormal_appendicular_skeleto0.81935322
140MP0004264_abnormal_extraembryonic_tissu0.81697118
141MP0000716_abnormal_immune_system0.81692747
142MP0000955_abnormal_spinal_cord0.81588400
143MP0009931_abnormal_skin_appearance0.81497758
144MP0002723_abnormal_immune_serum0.81347101
145MP0003123_paternal_imprinting0.81206712
146MP0005551_abnormal_eye_electrophysiolog0.81145255
147MP0003172_abnormal_lysosome_physiology0.80880169
148MP0005646_abnormal_pituitary_gland0.80433317
149MP0001661_extended_life_span0.79503473
150MP0003121_genomic_imprinting0.79073410
151MP0000537_abnormal_urethra_morphology0.79051424
152MP0002419_abnormal_innate_immunity0.78984143
153MP0002452_abnormal_antigen_presenting0.78351563
154MP0003075_altered_response_to0.77939729
155MP0009765_abnormal_xenobiotic_induced0.77880029
156MP0006054_spinal_hemorrhage0.77590566
157MP0002396_abnormal_hematopoietic_system0.75352452
158MP0000372_irregular_coat_pigmentation0.72897929
159MP0001727_abnormal_embryo_implantation0.72866656
160MP0002210_abnormal_sex_determination0.72647580
161MP0002111_abnormal_tail_morphology0.72146027
162MP0005391_vision/eye_phenotype0.72071132
163MP0001188_hyperpigmentation0.71794823
164MP0001929_abnormal_gametogenesis0.69864874
165MP0009333_abnormal_splenocyte_physiolog0.68643588
166MP0000647_abnormal_sebaceous_gland0.68320683
167MP0002932_abnormal_joint_morphology0.68311373
168MP0000350_abnormal_cell_proliferation0.67909213
169MP0005253_abnormal_eye_physiology0.66871282
170MP0005645_abnormal_hypothalamus_physiol0.65967199
171MP0002152_abnormal_brain_morphology0.65539043
172MP0001145_abnormal_male_reproductive0.64739436
173MP0003631_nervous_system_phenotype0.64355605
174MP0002066_abnormal_motor_capabilities/c0.64275968
175MP0002092_abnormal_eye_morphology0.64026272

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.93532641
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.93532641
3Cerebral hypomyelination (HP:0006808)4.92633759
4Parakeratosis (HP:0001036)4.41781333
5Increased serum pyruvate (HP:0003542)4.17969711
6Abnormality of glycolysis (HP:0004366)4.17969711
7Microvesicular hepatic steatosis (HP:0001414)3.85015045
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.75400732
9Testicular atrophy (HP:0000029)3.74377468
10Duplicated collecting system (HP:0000081)3.58465722
11Abnormal auditory evoked potentials (HP:0006958)3.51553700
12Neurofibrillary tangles (HP:0002185)3.51087027
133-Methylglutaconic aciduria (HP:0003535)3.49106868
14Leukodystrophy (HP:0002415)3.39185843
15Rough bone trabeculation (HP:0100670)3.29852713
16Sensory axonal neuropathy (HP:0003390)3.27838773
17Abnormality of the renal collecting system (HP:0004742)3.21987964
18Peripheral hypomyelination (HP:0007182)3.21083557
19Hypoplastic pelvis (HP:0008839)3.09249556
20Abnormality of the corticospinal tract (HP:0002492)3.06893567
21Cerebral edema (HP:0002181)3.03172311
22Acute necrotizing encephalopathy (HP:0006965)3.01958980
23Absent septum pellucidum (HP:0001331)2.97742903
24Alacrima (HP:0000522)2.91892827
25Renal Fanconi syndrome (HP:0001994)2.88511813
26Reticulocytopenia (HP:0001896)2.88037732
27Mitochondrial inheritance (HP:0001427)2.87256990
28Increased intramyocellular lipid droplets (HP:0012240)2.86991160
29Abnormality of cells of the erythroid lineage (HP:0012130)2.84064281
30Abnormal number of erythroid precursors (HP:0012131)2.83226023
31Abnormality of the septum pellucidum (HP:0007375)2.79691904
32Lactic acidosis (HP:0003128)2.79321490
33Morphological abnormality of the inner ear (HP:0011390)2.78033754
34Increased hepatocellular lipid droplets (HP:0006565)2.73496594
35Aplastic anemia (HP:0001915)2.73201148
36Birth length less than 3rd percentile (HP:0003561)2.70889971
37CNS hypomyelination (HP:0003429)2.68421943
38Ragged-red muscle fibers (HP:0003200)2.68325562
39Hepatocellular necrosis (HP:0001404)2.67361593
40Agammaglobulinemia (HP:0004432)2.63509394
41Abnormal trabecular bone morphology (HP:0100671)2.61788765
42Asplenia (HP:0001746)2.61528851
43Increased muscle lipid content (HP:0009058)2.60864720
44Pili torti (HP:0003777)2.53304432
45Decreased lacrimation (HP:0000633)2.49018281
46Hepatosplenomegaly (HP:0001433)2.48418209
47Lethargy (HP:0001254)2.47916118
48Patchy hypopigmentation of hair (HP:0011365)2.46280927
49Abnormal mitochondria in muscle tissue (HP:0008316)2.45378769
50Progressive muscle weakness (HP:0003323)2.43856528
51Abnormal protein glycosylation (HP:0012346)2.43268330
52Abnormal glycosylation (HP:0012345)2.43268330
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43268330
54Abnormal protein N-linked glycosylation (HP:0012347)2.43268330
55Congenital ichthyosiform erythroderma (HP:0007431)2.42379931
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41684966
57Anteriorly placed anus (HP:0001545)2.40209753
58Exercise intolerance (HP:0003546)2.39065135
59Elevated erythrocyte sedimentation rate (HP:0003565)2.38983916
60Pancytopenia (HP:0001876)2.38567074
61Multiple enchondromatosis (HP:0005701)2.38207191
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37211598
63White forelock (HP:0002211)2.36482189
64Acute encephalopathy (HP:0006846)2.35642249
65Lipid accumulation in hepatocytes (HP:0006561)2.35550561
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.35361362
67Partial duplication of thumb phalanx (HP:0009944)2.34894829
68Oral leukoplakia (HP:0002745)2.32573933
69Increased CSF lactate (HP:0002490)2.30529814
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30180648
71Dicarboxylic aciduria (HP:0003215)2.30180648
72Thrombocytosis (HP:0001894)2.29997456
73Absent thumb (HP:0009777)2.29464621
74Duplication of thumb phalanx (HP:0009942)2.29014340
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.28872304
76Macrocytic anemia (HP:0001972)2.26939328
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.25531179
78Progressive macrocephaly (HP:0004481)2.24702570
79Septo-optic dysplasia (HP:0100842)2.23977525
80Increased serum ferritin (HP:0003281)2.22894187
81B lymphocytopenia (HP:0010976)2.18786191
82Reduced antithrombin III activity (HP:0001976)2.18178589
83Postnatal microcephaly (HP:0005484)2.17852517
84Prolonged neonatal jaundice (HP:0006579)2.16626536
85Respiratory difficulties (HP:0002880)2.15980183
86Abnormality of the preputium (HP:0100587)2.15358383
87Retinal dysplasia (HP:0007973)2.14860781
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14341288
89Pallor (HP:0000980)2.14338952
90Panhypogammaglobulinemia (HP:0003139)2.13004931
91Onion bulb formation (HP:0003383)2.12873384
92Sparse eyelashes (HP:0000653)2.12667772
93Partial duplication of the phalanx of hand (HP:0009999)2.12182264
94Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12067702
95Autoimmune hemolytic anemia (HP:0001890)2.10683895
96Petechiae (HP:0000967)2.10017939
97Abnormal lung lobation (HP:0002101)2.09915931
98Poikiloderma (HP:0001029)2.09610247
99Abnormality of B cell number (HP:0010975)2.09580175
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07970975
101Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06211509
102Abnormal hair laboratory examination (HP:0003328)2.04765580
103Generalized aminoaciduria (HP:0002909)2.03304581
104Spastic gait (HP:0002064)2.01426223
105Opisthotonus (HP:0002179)2.01188156
106Respiratory failure (HP:0002878)2.01015495
107Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01015127
108Breast hypoplasia (HP:0003187)1.96556848
109Split foot (HP:0001839)1.96417028
110Hypertensive crisis (HP:0100735)1.96139278
111Cerebral inclusion bodies (HP:0100314)1.96003029
112Abnormality of subcutaneous fat tissue (HP:0001001)1.95382193
113Hepatic necrosis (HP:0002605)1.95036962
114Stenosis of the external auditory canal (HP:0000402)1.94765760
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93282134
116Stridor (HP:0010307)1.92796131
117Spastic paraparesis (HP:0002313)1.92765952
118Adrenal hypoplasia (HP:0000835)1.92563499
119Death in infancy (HP:0001522)1.92558609
120Squamous cell carcinoma (HP:0002860)1.92434399
121Emotional lability (HP:0000712)1.90964830
122Cerebral palsy (HP:0100021)1.90390541
123Cupped ear (HP:0000378)1.89768091
124CNS demyelination (HP:0007305)1.87384305
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85961716
126Absent epiphyses (HP:0010577)1.85961716
127Chronic obstructive pulmonary disease (HP:0006510)1.85793922
128Obstructive lung disease (HP:0006536)1.85793922
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85570588
130Hyperthyroidism (HP:0000836)1.84407617
131Increased cerebral lipofuscin (HP:0011813)1.83518482
132Hyperammonemia (HP:0001987)1.83497507
133Premature skin wrinkling (HP:0100678)1.82420278
134Chromsome breakage (HP:0040012)1.82022668
135Progressive microcephaly (HP:0000253)1.82009141
136Microretrognathia (HP:0000308)1.81820114
137Trismus (HP:0000211)1.81116263
138Seborrheic dermatitis (HP:0001051)1.80800380
139Brittle hair (HP:0002299)1.79793629
140Esophageal atresia (HP:0002032)1.79562608
141Autoamputation (HP:0001218)1.79540005
142Segmental peripheral demyelination/remyelination (HP:0003481)1.79315983
143Increased serum lactate (HP:0002151)1.78237634
144Exertional dyspnea (HP:0002875)1.74655686
145Absent radius (HP:0003974)1.74544639
146Abnormality of the prostate (HP:0008775)1.74303046
147Abnormal umbilical cord blood vessels (HP:0011403)1.72964632
148Single umbilical artery (HP:0001195)1.72964632
149Abnormality of the fetal cardiovascular system (HP:0010948)1.72964632
150Cellulitis (HP:0100658)1.71933069
151Thickened helices (HP:0000391)1.71777574
152Ketoacidosis (HP:0001993)1.71328523
153Fragile nails (HP:0001808)1.70769652
154Abnormality of fatty-acid metabolism (HP:0004359)1.70104487
155Entropion (HP:0000621)1.70076186
156Optic disc pallor (HP:0000543)1.67643500
157Poor head control (HP:0002421)1.64707982
158Abnormal number of incisors (HP:0011064)1.63689817
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62636725
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62636725
161Premature graying of hair (HP:0002216)1.62311726
162Type I transferrin isoform profile (HP:0003642)1.62156065
163Prominent occiput (HP:0000269)1.62089508
164Aplasia involving forearm bones (HP:0009822)1.61486610
165Absent forearm bone (HP:0003953)1.61486610
166Abnormality of cochlea (HP:0000375)1.58906107
167Overfolded helix (HP:0000396)1.57083424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.20951111
2STK394.26364341
3BUB13.61507109
4OXSR13.15456808
5PBK3.02310046
6TESK22.93326443
7TLK12.92166493
8CDK192.69796779
9BCKDK2.62714678
10MAPKAPK32.49815039
11SCYL22.48525982
12SMG12.44521646
13TESK12.44146203
14CLK12.43455360
15ERN12.36425428
16BCR2.34604877
17MAPKAPK52.31095187
18STK162.29503650
19RPS6KB22.22203351
20PKN12.14226869
21CDC72.14225936
22EPHA22.11085784
23MKNK12.10884454
24UHMK12.06345707
25KDR1.99960143
26VRK11.92462716
27WEE11.91182805
28CSNK1G31.86600876
29LIMK11.85329114
30MAP3K111.69842881
31PIM21.67328106
32DYRK21.59595594
33DAPK11.57722629
34MST1R1.56979678
35CSNK1A1L1.55819347
36SRPK11.52409787
37EIF2AK11.51520930
38TRIB31.50883771
39BMPR1B1.50015262
40EPHB11.42069429
41TAF11.40436005
42PNCK1.38066912
43MET1.37444659
44CSNK1G11.34849906
45WNK41.29167394
46BLK1.27655120
47EIF2AK31.26320471
48ABL21.25373111
49PKN21.24101137
50FGFR21.24090608
51PRKD31.24041073
52ZAK1.22969740
53ARAF1.22295035
54NUAK11.16724130
55RPS6KA51.15989210
56EEF2K1.15782689
57FLT31.15337822
58MST41.11242483
59NEK61.10150071
60CAMK2B1.09238116
61MKNK21.08510499
62LRRK21.07816757
63PRPF4B1.07021072
64TNK21.04446404
65CASK1.01982973
66PRKCI1.01093109
67CDK81.00844368
68TBK10.99950566
69ROCK20.99244272
70PASK0.98443156
71WNK10.98380640
72CSNK1G20.97775275
73DYRK30.95530969
74NME20.94977795
75TAOK30.93075450
76IRAK30.92786561
77PLK40.90656065
78ICK0.90238936
79PDK20.83456911
80CDK140.82718280
81CDK150.82314124
82STK40.82075488
83CDK11A0.79904734
84CDK180.79399858
85PAK40.75173993
86CCNB10.73424607
87TNIK0.72889898
88IRAK20.72452401
89TTK0.70634200
90PAK10.70197747
91FES0.69103493
92NEK10.67894917
93AURKA0.64471054
94NME10.63817304
95CDK70.63783017
96ATR0.62650707
97CAMK2D0.62320940
98CSF1R0.61047930
99FGR0.61029071
100MAP4K10.58959720
101YES10.58892588
102TSSK60.58615754
103PLK10.56762778
104IRAK40.55818732
105BRSK10.54667794
106ADRBK20.54666783
107GRK60.53767933
108BRAF0.53506002
109SIK10.53458847
110MAP3K80.53366360
111AURKB0.53205413
112PTK60.52679652
113PRKCQ0.52552724
114INSRR0.49554711
115EIF2AK20.48399986
116CSNK1D0.47409091
117CHEK20.47379260
118DAPK30.47231391
119CAMK2G0.47020669
120CHEK10.46608483
121ITK0.46149519
122CSNK2A10.46004453
123CSNK2A20.45781981
124MELK0.44541588
125SGK2230.44352880
126SGK4940.44352880
127ACVR1B0.44161187
128PLK30.43632837
129BTK0.43257974
130MAPK130.41086802
131MAP4K20.40492228
132BRSK20.39999061
133MAPKAPK20.38504511
134MAP3K120.38486836
135STK100.36478086
136CDK10.35781484
137LYN0.35651184
138NEK20.35596330
139IKBKB0.34108207
140KIT0.34026093
141AKT20.33891368
142TRPM70.33492573
143PRKCD0.33440066
144ILK0.33180478
145IRAK10.32854180
146CDK30.32634515
147ZAP700.31697281
148CSNK1A10.31253693
149MAPK150.30974358
150CDK20.30610730
151MUSK0.29899761
152MAP2K60.28052592
153CDK90.27652840
154SIK30.26378836
155MAP2K20.25837645
156ADRBK10.25325783
157PRKG20.25306431

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.02264224
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.00457161
3Mismatch repair_Homo sapiens_hsa034303.54227545
4Ribosome_Homo sapiens_hsa030103.28910906
5Protein export_Homo sapiens_hsa030603.21338997
6Fatty acid elongation_Homo sapiens_hsa000623.04063184
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03846932
8RNA polymerase_Homo sapiens_hsa030202.96163137
9Proteasome_Homo sapiens_hsa030502.86818022
10Steroid biosynthesis_Homo sapiens_hsa001002.74661186
11Homologous recombination_Homo sapiens_hsa034402.58371076
12Spliceosome_Homo sapiens_hsa030402.58127867
13Oxidative phosphorylation_Homo sapiens_hsa001902.47321149
14Base excision repair_Homo sapiens_hsa034102.46193517
15Non-homologous end-joining_Homo sapiens_hsa034502.28115019
16Parkinsons disease_Homo sapiens_hsa050122.25989300
17Nucleotide excision repair_Homo sapiens_hsa034202.23756207
18Ether lipid metabolism_Homo sapiens_hsa005652.02255317
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92883761
20Pyrimidine metabolism_Homo sapiens_hsa002401.86769630
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81445237
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65387602
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58016008
24Fanconi anemia pathway_Homo sapiens_hsa034601.55224284
25Basal transcription factors_Homo sapiens_hsa030221.55149863
26Cell cycle_Homo sapiens_hsa041101.52760736
27Huntingtons disease_Homo sapiens_hsa050161.51724585
28Alzheimers disease_Homo sapiens_hsa050101.49344479
29Biosynthesis of amino acids_Homo sapiens_hsa012301.47281661
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46202060
31Vitamin B6 metabolism_Homo sapiens_hsa007501.39687643
32One carbon pool by folate_Homo sapiens_hsa006701.38811511
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36150512
34Systemic lupus erythematosus_Homo sapiens_hsa053221.32338027
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30949754
36Linoleic acid metabolism_Homo sapiens_hsa005911.28837686
37Folate biosynthesis_Homo sapiens_hsa007901.26019421
38RNA transport_Homo sapiens_hsa030131.23798873
39Fructose and mannose metabolism_Homo sapiens_hsa000511.20638632
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19869641
41Carbon metabolism_Homo sapiens_hsa012001.15549768
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15228077
43Purine metabolism_Homo sapiens_hsa002301.13241336
44RNA degradation_Homo sapiens_hsa030181.10445719
45Sphingolipid metabolism_Homo sapiens_hsa006001.05243333
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03696201
47Glutathione metabolism_Homo sapiens_hsa004801.01638276
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97999953
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97976911
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90835553
51Histidine metabolism_Homo sapiens_hsa003400.90380695
52Selenocompound metabolism_Homo sapiens_hsa004500.90088917
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90058832
54Alcoholism_Homo sapiens_hsa050340.84782368
55Arachidonic acid metabolism_Homo sapiens_hsa005900.83930991
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.83882848
57Arginine and proline metabolism_Homo sapiens_hsa003300.81447964
58Sulfur metabolism_Homo sapiens_hsa009200.80655105
59Pyruvate metabolism_Homo sapiens_hsa006200.80061687
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79834958
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79427793
62mRNA surveillance pathway_Homo sapiens_hsa030150.76023010
63Galactose metabolism_Homo sapiens_hsa000520.72402824
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71704958
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.65836969
66Metabolic pathways_Homo sapiens_hsa011000.61281401
67Other glycan degradation_Homo sapiens_hsa005110.59749999
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58889283
69Axon guidance_Homo sapiens_hsa043600.56973654
70Vitamin digestion and absorption_Homo sapiens_hsa049770.55234440
71Autoimmune thyroid disease_Homo sapiens_hsa053200.55161506
72Primary immunodeficiency_Homo sapiens_hsa053400.53262250
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52658409
74Asthma_Homo sapiens_hsa053100.52249937
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52037411
76Hedgehog signaling pathway_Homo sapiens_hsa043400.51870450
77Phenylalanine metabolism_Homo sapiens_hsa003600.51252601
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50947877
79Chemical carcinogenesis_Homo sapiens_hsa052040.49642056
80Epstein-Barr virus infection_Homo sapiens_hsa051690.48782879
81Antigen processing and presentation_Homo sapiens_hsa046120.48326324
82Basal cell carcinoma_Homo sapiens_hsa052170.45896938
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44113505
84Viral carcinogenesis_Homo sapiens_hsa052030.39340996
85Fatty acid metabolism_Homo sapiens_hsa012120.37126049
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36974496
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.36764430
88Cardiac muscle contraction_Homo sapiens_hsa042600.35915183
89Sulfur relay system_Homo sapiens_hsa041220.33581867
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33431552
91beta-Alanine metabolism_Homo sapiens_hsa004100.31778990
92Phototransduction_Homo sapiens_hsa047440.29095095
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27985534
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27709859
95Lysosome_Homo sapiens_hsa041420.26211683
96Allograft rejection_Homo sapiens_hsa053300.25296852
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.24348723
98Collecting duct acid secretion_Homo sapiens_hsa049660.23046743
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22640442
100Legionellosis_Homo sapiens_hsa051340.22496908
101p53 signaling pathway_Homo sapiens_hsa041150.22300393
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20218076
103Serotonergic synapse_Homo sapiens_hsa047260.20128316
104Notch signaling pathway_Homo sapiens_hsa043300.19666802
105Fatty acid degradation_Homo sapiens_hsa000710.19239958
106Propanoate metabolism_Homo sapiens_hsa006400.19179063
107Malaria_Homo sapiens_hsa051440.18900106
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.18475764
109Tight junction_Homo sapiens_hsa045300.18418960
110Wnt signaling pathway_Homo sapiens_hsa043100.18247958
111Hematopoietic cell lineage_Homo sapiens_hsa046400.18019304
112Type I diabetes mellitus_Homo sapiens_hsa049400.17895366
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17597426
114Renal cell carcinoma_Homo sapiens_hsa052110.16673995
115Acute myeloid leukemia_Homo sapiens_hsa052210.15521587
116Vibrio cholerae infection_Homo sapiens_hsa051100.15424875
117Tyrosine metabolism_Homo sapiens_hsa003500.15355543
118Oocyte meiosis_Homo sapiens_hsa041140.14560853
119Herpes simplex infection_Homo sapiens_hsa051680.12777668
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.12632931
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.10860974
122Peroxisome_Homo sapiens_hsa041460.10845144
123Rheumatoid arthritis_Homo sapiens_hsa053230.10791578
124Phagosome_Homo sapiens_hsa041450.09701319
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09362290
126N-Glycan biosynthesis_Homo sapiens_hsa005100.06908039
127Shigellosis_Homo sapiens_hsa051310.06694120
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.06604571
129Butanoate metabolism_Homo sapiens_hsa006500.05904451
130Graft-versus-host disease_Homo sapiens_hsa053320.05773545
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05742831
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05456853
133Pathways in cancer_Homo sapiens_hsa052000.04941570
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.04684497
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.04013866
136Pentose phosphate pathway_Homo sapiens_hsa000300.03750655

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