NMRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.11361954
2doxorubicin metabolic process (GO:0044598)5.11361954
3daunorubicin metabolic process (GO:0044597)5.11361954
4indole-containing compound catabolic process (GO:0042436)5.04605796
5indolalkylamine catabolic process (GO:0046218)5.04605796
6tryptophan catabolic process (GO:0006569)5.04605796
7aromatic amino acid family catabolic process (GO:0009074)4.88954022
8tryptophan metabolic process (GO:0006568)4.78683112
9L-phenylalanine catabolic process (GO:0006559)4.68378126
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.68378126
11imidazole-containing compound metabolic process (GO:0052803)4.42998129
12aminoglycoside antibiotic metabolic process (GO:0030647)4.35986858
13L-phenylalanine metabolic process (GO:0006558)4.34241013
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34241013
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31092657
16negative regulation of cell killing (GO:0031342)4.13281552
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.13281552
18cellular biogenic amine catabolic process (GO:0042402)4.04598992
19amine catabolic process (GO:0009310)4.04598992
20regulation of regulatory T cell differentiation (GO:0045589)4.00531599
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99501206
22kynurenine metabolic process (GO:0070189)3.86574243
23positive regulation of gamma-delta T cell activation (GO:0046645)3.81096508
24nitrogen cycle metabolic process (GO:0071941)3.79812603
25indolalkylamine metabolic process (GO:0006586)3.72981294
26cytidine deamination (GO:0009972)3.72402963
27cytidine metabolic process (GO:0046087)3.72402963
28cytidine catabolic process (GO:0006216)3.72402963
29urea cycle (GO:0000050)3.71687773
30urea metabolic process (GO:0019627)3.71687773
31aromatic amino acid family metabolic process (GO:0009072)3.70357088
32bile acid biosynthetic process (GO:0006699)3.59130587
33* NAD biosynthetic process (GO:0009435)3.53989694
34drug catabolic process (GO:0042737)3.53467757
35aldehyde catabolic process (GO:0046185)3.45581790
36regulation of activation of Janus kinase activity (GO:0010533)3.44042738
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41859388
38tachykinin receptor signaling pathway (GO:0007217)3.40158528
39regulation of gamma-delta T cell differentiation (GO:0045586)3.39148138
40regulation of B cell receptor signaling pathway (GO:0050855)3.36871540
41glyoxylate metabolic process (GO:0046487)3.36430437
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.36221518
43urate metabolic process (GO:0046415)3.31428419
44drug transmembrane transport (GO:0006855)3.31364513
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.30643242
46exogenous drug catabolic process (GO:0042738)3.30210029
47serine family amino acid catabolic process (GO:0009071)3.29814057
48regulation of gamma-delta T cell activation (GO:0046643)3.28321344
49cellular glucuronidation (GO:0052695)3.27974924
50high-density lipoprotein particle remodeling (GO:0034375)3.26667930
51trivalent inorganic anion homeostasis (GO:0072506)3.24791550
52phosphate ion homeostasis (GO:0055062)3.24791550
53negative T cell selection (GO:0043383)3.22911970
54alpha-amino acid catabolic process (GO:1901606)3.20722507
55tyrosine metabolic process (GO:0006570)3.20676363
56amino-acid betaine metabolic process (GO:0006577)3.17573102
57antigen processing and presentation of endogenous antigen (GO:0019883)3.16746029
58cellular anion homeostasis (GO:0030002)3.15588901
59glucuronate metabolic process (GO:0019585)3.14102846
60uronic acid metabolic process (GO:0006063)3.14102846
61neutrophil activation involved in immune response (GO:0002283)3.14101227
62regulation of cholesterol esterification (GO:0010872)3.13545580
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12851499
64cysteine metabolic process (GO:0006534)3.10887610
65bile acid metabolic process (GO:0008206)3.08325210
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05171879
67phospholipid efflux (GO:0033700)3.00644648
68regulation of bile acid biosynthetic process (GO:0070857)2.93913145
69proteasome assembly (GO:0043248)2.93127172
70homocysteine metabolic process (GO:0050667)2.91107372
71adaptation of signaling pathway (GO:0023058)2.89974613
72* nicotinamide nucleotide biosynthetic process (GO:0019359)2.87632747
73* pyridine nucleotide biosynthetic process (GO:0019363)2.87632747
74drug transport (GO:0015893)2.86724191
75regulation of T cell tolerance induction (GO:0002664)2.85935569
76proline metabolic process (GO:0006560)2.85359349
77serine family amino acid metabolic process (GO:0009069)2.85193979
78regulation of T cell mediated cytotoxicity (GO:0001914)2.84662767
79triglyceride homeostasis (GO:0070328)2.84122827
80acylglycerol homeostasis (GO:0055090)2.84122827
81bile acid and bile salt transport (GO:0015721)2.83925766
82positive T cell selection (GO:0043368)2.83097214
83peptidyl-glutamic acid carboxylation (GO:0017187)2.82956566
84protein carboxylation (GO:0018214)2.82956566
85T cell migration (GO:0072678)2.82498915
86negative thymic T cell selection (GO:0045060)2.81653939
87glycine metabolic process (GO:0006544)2.80071582
88positive regulation of digestive system process (GO:0060456)2.79998317
89positive regulation of tolerance induction (GO:0002645)2.79681636
90benzene-containing compound metabolic process (GO:0042537)2.79476958
91regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79357504
92cellular amino acid catabolic process (GO:0009063)2.78611571
93arginine metabolic process (GO:0006525)2.78498832
94DNA deamination (GO:0045006)2.78243821
95serine family amino acid biosynthetic process (GO:0009070)2.78039365
96response to nitrosative stress (GO:0051409)2.74700250
97diterpenoid biosynthetic process (GO:0016102)2.74275457
98dopamine transport (GO:0015872)2.73052885
99antigen processing and presentation via MHC class Ib (GO:0002475)2.72028799
100blood coagulation, intrinsic pathway (GO:0007597)2.71506741
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71308175
102dendritic cell chemotaxis (GO:0002407)2.69259249
103regulation of T cell receptor signaling pathway (GO:0050856)2.67948033
104positive regulation of B cell differentiation (GO:0045579)2.65779210
105coenzyme catabolic process (GO:0009109)2.64063757
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61964637
107cellular response to interleukin-15 (GO:0071350)2.61929287
108reverse cholesterol transport (GO:0043691)2.60867996
109cofactor catabolic process (GO:0051187)2.60686630
110plasma lipoprotein particle remodeling (GO:0034369)2.59377688
111protein-lipid complex remodeling (GO:0034368)2.59377688
112macromolecular complex remodeling (GO:0034367)2.59377688
113positive regulation of natural killer cell differentiation (GO:0032825)2.59289083
114low-density lipoprotein particle remodeling (GO:0034374)2.58446754
115regulation of tolerance induction (GO:0002643)2.58271587
116terpenoid biosynthetic process (GO:0016114)2.58267420
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57678927
118response to interleukin-15 (GO:0070672)2.57407233
119regulation of protein activation cascade (GO:2000257)2.56180471
120organic acid catabolic process (GO:0016054)2.55945736
121carboxylic acid catabolic process (GO:0046395)2.55945736
122positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55885701
123pyrimidine nucleoside catabolic process (GO:0046135)2.55157780
124regulation of germinal center formation (GO:0002634)2.55004776
125type I interferon signaling pathway (GO:0060337)2.54444887
126cellular response to type I interferon (GO:0071357)2.54444887
127lysine metabolic process (GO:0006553)2.53843931
128lysine catabolic process (GO:0006554)2.53843931
129regulation of fibrinolysis (GO:0051917)2.53834443
130detection of bacterium (GO:0016045)2.53500242
131regulation of alpha-beta T cell proliferation (GO:0046640)2.53373091
132leukocyte aggregation (GO:0070486)2.52956543
133tolerance induction (GO:0002507)2.51469522
134sulfur amino acid catabolic process (GO:0000098)2.49586635
135response to type I interferon (GO:0034340)2.49361864
136positive regulation of lipoprotein lipase activity (GO:0051006)2.49187158
137positive regulation of triglyceride lipase activity (GO:0061365)2.49187158
138activated T cell proliferation (GO:0050798)2.49147362
139drug metabolic process (GO:0017144)2.48129929
140branched-chain amino acid catabolic process (GO:0009083)2.46903541
141Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46831973
142complement activation, alternative pathway (GO:0006957)2.46706675
143detection of external biotic stimulus (GO:0098581)2.45908414
144regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45813254
145nucleotide transmembrane transport (GO:1901679)2.45532643
146positive thymic T cell selection (GO:0045059)2.45049671
147dendritic cell migration (GO:0036336)2.43065432
148positive regulation of granulocyte differentiation (GO:0030854)2.42674738
149regulation of leukocyte mediated cytotoxicity (GO:0001910)2.42565166
150carnitine metabolic process (GO:0009437)2.41414468
151T cell selection (GO:0045058)2.41338373
152detection of molecule of bacterial origin (GO:0032490)2.41284441
153valine metabolic process (GO:0006573)2.41136197
154regulation of hexokinase activity (GO:1903299)2.40797584
155regulation of glucokinase activity (GO:0033131)2.40797584
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.40549353
157neutrophil activation (GO:0042119)2.39922677
158positive regulation of calcium-mediated signaling (GO:0050850)2.38749014
159regulation of type B pancreatic cell apoptotic process (GO:2000674)2.35757565
160T cell costimulation (GO:0031295)2.35059298
161regulation of B cell differentiation (GO:0045577)2.34738163
162immunoglobulin mediated immune response (GO:0016064)2.34631903
163positive regulation of antigen processing and presentation (GO:0002579)2.34472337
164negative regulation of T cell apoptotic process (GO:0070233)2.34205214
165negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.33948590
166lymphocyte costimulation (GO:0031294)2.31748839
167myeloid cell activation involved in immune response (GO:0002275)2.31329063
168regulation of memory T cell differentiation (GO:0043380)2.31153429
169negative regulation of execution phase of apoptosis (GO:1900118)2.31066603
170actin nucleation (GO:0045010)2.30854804
171negative regulation of T cell receptor signaling pathway (GO:0050860)2.30683601
172negative regulation of T cell mediated immunity (GO:0002710)2.30410867
173regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.29793644
174regulation of natural killer cell mediated immunity (GO:0002715)2.29793644
175positive regulation of alpha-beta T cell proliferation (GO:0046641)2.28132989
176regulation of calcium-mediated signaling (GO:0050848)2.27616186
177granulocyte activation (GO:0036230)2.26835098
178T cell receptor signaling pathway (GO:0050852)2.26822624
179positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.26364623
180leukocyte degranulation (GO:0043299)2.26271724
181lymphocyte chemotaxis (GO:0048247)2.26267364
182positive regulation of defense response to virus by host (GO:0002230)2.24599278
183regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.23907927
184negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.22888809
185mast cell activation (GO:0045576)2.22881695
186regulation of interferon-beta biosynthetic process (GO:0045357)2.22121822
187interferon-gamma-mediated signaling pathway (GO:0060333)2.19304040
188regulation of antigen processing and presentation (GO:0002577)2.17033820
189antigen receptor-mediated signaling pathway (GO:0050851)2.16694302
190chemokine-mediated signaling pathway (GO:0070098)2.15773863
191negative regulation of leukocyte mediated immunity (GO:0002704)2.14676701
192G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.14486877
193regulation of cell killing (GO:0031341)2.14250826
194negative regulation of protein autophosphorylation (GO:0031953)2.13720019
195response to interferon-beta (GO:0035456)2.13662987
196regulation of isotype switching to IgG isotypes (GO:0048302)2.12764989
197negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.12336170
198negative regulation of T-helper cell differentiation (GO:0045623)2.12336170
199regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.11256507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36501147
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.11355229
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11195714
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.87338409
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.66734462
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.51654459
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29075161
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25905846
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.23267400
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.06979653
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96449227
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.78033869
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56427598
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.56094986
15RUNX_20019798_ChIP-Seq_JUKART_Human2.48048176
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41836646
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35590553
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.31222233
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29874424
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28074397
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25409908
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.22666595
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.15800741
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.14578238
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10695335
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10174036
27PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10001032
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09355584
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.98512661
30KAP1_22055183_ChIP-Seq_ESCs_Mouse1.92028643
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91074310
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.90112505
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88063333
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.87180296
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77265688
36IRF1_19129219_ChIP-ChIP_H3396_Human1.77043355
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.74124937
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72213195
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71885446
40MYB_26560356_Chip-Seq_TH2_Human1.69173423
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68666303
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67988184
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64994164
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56537690
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56488886
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55284292
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.54411061
48GATA3_26560356_Chip-Seq_TH2_Human1.54362861
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53844590
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48493097
51BCAT_22108803_ChIP-Seq_LS180_Human1.47521845
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46814482
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46119577
54VDR_24787735_ChIP-Seq_THP-1_Human1.44228327
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43113840
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41021640
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39200268
58GATA3_27048872_Chip-Seq_THYMUS_Human1.39002663
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.35995970
60HTT_18923047_ChIP-ChIP_STHdh_Human1.35909995
61VDR_23849224_ChIP-Seq_CD4+_Human1.35367426
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33618845
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32299040
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32261482
65VDR_22108803_ChIP-Seq_LS180_Human1.29063238
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26381521
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25811837
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24987332
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24900485
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22783874
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22705196
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22152796
73ELK1_19687146_ChIP-ChIP_HELA_Human1.20850750
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19466129
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.17266632
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16743376
77MYB_26560356_Chip-Seq_TH1_Human1.16501972
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.15950415
79E2F7_22180533_ChIP-Seq_HELA_Human1.15139200
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.14861118
81SCL_19346495_ChIP-Seq_HPC-7_Human1.14344058
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13574760
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13315089
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.13308814
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12458956
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12369754
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.12065886
88GBX2_23144817_ChIP-Seq_PC3_Human1.11477160
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10599580
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10371508
91P300_18555785_Chip-Seq_ESCs_Mouse1.10344393
92ER_23166858_ChIP-Seq_MCF-7_Human1.10215453
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10025097
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09782104
95FOXP3_21729870_ChIP-Seq_TREG_Human1.08919962
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07902409
97P53_22387025_ChIP-Seq_ESCs_Mouse1.07060914
98ZFX_18555785_Chip-Seq_ESCs_Mouse1.05542663
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05405812
100PU1_27457419_Chip-Seq_LIVER_Mouse1.05325454
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04196828
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04090183
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02492371
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.02135906
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02073046
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01892884
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01798311
108ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01539016
109SPI1_23127762_ChIP-Seq_K562_Human1.01486134
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01246219
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.00922715
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00635452
113TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00632063
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00319510
115TAF15_26573619_Chip-Seq_HEK293_Human0.99491685
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.98783001
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.98166015
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.97721541
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96023849
120MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95601694
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95351161
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94784960
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.93993466
124SPI1_23547873_ChIP-Seq_NB4_Human0.93779834
125CDX2_22108803_ChIP-Seq_LS180_Human0.93742867
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.92496614
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91841951
128NANOG_19829295_ChIP-Seq_ESCs_Human0.91172809
129SOX2_19829295_ChIP-Seq_ESCs_Human0.91172809
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90917252
131STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90903458
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90860913
133AR_20517297_ChIP-Seq_VCAP_Human0.90388974
134GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89964219
135SMRT_27268052_Chip-Seq_Bcells_Human0.89415939
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.88540714
137STAT1_20625510_ChIP-Seq_HELA_Human0.88531539
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87796625
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87776211
140CTCF_18555785_Chip-Seq_ESCs_Mouse0.87678039
141MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87444329
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87360420
143TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86566406
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86215495
145GATA1_22025678_ChIP-Seq_K562_Human0.85885342
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84875073
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83946568
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.83946568
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82718391
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81063570
151GATA3_26560356_Chip-Seq_TH1_Human0.80933739
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80843145
153GATA2_19941826_ChIP-Seq_K562_Human0.79437974
154P300_19829295_ChIP-Seq_ESCs_Human0.79124300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.23029563
2MP0005360_urolithiasis4.61063643
3MP0005085_abnormal_gallbladder_physiolo4.20397012
4MP0005365_abnormal_bile_salt3.74987627
5MP0008875_abnormal_xenobiotic_pharmacok3.52574275
6MP0003806_abnormal_nucleotide_metabolis3.26356325
7MP0004019_abnormal_vitamin_homeostasis2.84209674
8MP0009697_abnormal_copulation2.60476795
9MP0003195_calcinosis2.51622050
10MP0002138_abnormal_hepatobiliary_system2.49979932
11MP0002876_abnormal_thyroid_physiology2.25755579
12MP0005332_abnormal_amino_acid2.25513235
13MP0003252_abnormal_bile_duct2.16320591
14MP0001764_abnormal_homeostasis2.13549932
15MP0003186_abnormal_redox_activity1.94493256
16MP0009780_abnormal_chondrocyte_physiolo1.87893096
17MP0010329_abnormal_lipoprotein_level1.85852129
18MP0006292_abnormal_olfactory_placode1.84802641
19MP0001501_abnormal_sleep_pattern1.81134527
20MP0002420_abnormal_adaptive_immunity1.79848179
21MP0001835_abnormal_antigen_presentation1.76894143
22MP0005647_abnormal_sex_gland1.76815690
23MP0005451_abnormal_body_composition1.76371196
24MP0005377_hearing/vestibular/ear_phenot1.74623601
25MP0003878_abnormal_ear_physiology1.74623601
26MP0001986_abnormal_taste_sensitivity1.74149758
27MP0002166_altered_tumor_susceptibility1.66347072
28MP0009764_decreased_sensitivity_to1.63678829
29MP0008057_abnormal_DNA_replication1.58346115
30MP0000566_synostosis1.58149111
31MP0010155_abnormal_intestine_physiology1.57797870
32MP0003868_abnormal_feces_composition1.55960322
33MP0003866_abnormal_defecation1.52945237
34MP0005075_abnormal_melanosome_morpholog1.52880280
35MP0001533_abnormal_skeleton_physiology1.51633959
36MP0009840_abnormal_foam_cell1.50726286
37MP0009785_altered_susceptibility_to1.49165317
38MP0003724_increased_susceptibility_to1.47087975
39MP0002405_respiratory_system_inflammati1.44301979
40MP0000465_gastrointestinal_hemorrhage1.44048677
41MP0002933_joint_inflammation1.43752979
42MP0009333_abnormal_splenocyte_physiolog1.39749618
43MP0002132_abnormal_respiratory_system1.38446849
44MP0002277_abnormal_respiratory_mucosa1.38097662
45MP0002693_abnormal_pancreas_physiology1.37777203
46MP0001666_abnormal_nutrient_absorption1.37235477
47MP0003941_abnormal_skin_development1.37086107
48MP0004381_abnormal_hair_follicle1.33142136
49MP0003303_peritoneal_inflammation1.31799897
50MP0003172_abnormal_lysosome_physiology1.31614104
51MP0003045_fibrosis1.30841381
52MP0000716_abnormal_immune_system1.30794104
53MP0009643_abnormal_urine_homeostasis1.29546543
54MP0003011_delayed_dark_adaptation1.27120692
55MP0000609_abnormal_liver_physiology1.25301724
56MP0004782_abnormal_surfactant_physiolog1.25014103
57MP0005408_hypopigmentation1.24667976
58MP0003718_maternal_effect1.24363021
59MP0002148_abnormal_hypersensitivity_rea1.23671603
60MP0006054_spinal_hemorrhage1.23392300
61MP0002398_abnormal_bone_marrow1.20636857
62MP0008058_abnormal_DNA_repair1.20133866
63MP0000685_abnormal_immune_system1.18473292
64MP0008469_abnormal_protein_level1.18340802
65MP0005379_endocrine/exocrine_gland_phen1.18328717
66MP0005319_abnormal_enzyme/_coenzyme1.18066649
67MP0002837_dystrophic_cardiac_calcinosis1.17586499
68MP0004510_myositis1.16036631
69MP0003075_altered_response_to1.15557900
70MP0002160_abnormal_reproductive_system1.14875428
71MP0005671_abnormal_response_to1.13733527
72MP0005083_abnormal_biliary_tract1.13610079
73MP0002118_abnormal_lipid_homeostasis1.12774189
74MP0005646_abnormal_pituitary_gland1.11974955
75MP0001873_stomach_inflammation1.10453023
76MP0001765_abnormal_ion_homeostasis1.10380916
77MP0005645_abnormal_hypothalamus_physiol1.08959905
78MP0005310_abnormal_salivary_gland1.08146147
79MP0001851_eye_inflammation1.07898218
80MP0003300_gastrointestinal_ulcer1.07857786
81MP0002009_preneoplasia1.04724744
82MP0003191_abnormal_cellular_cholesterol1.04244844
83MP0000015_abnormal_ear_pigmentation1.03578413
84MP0005167_abnormal_blood-brain_barrier1.02597946
85MP0003786_premature_aging1.02489323
86MP0005535_abnormal_body_temperature1.02007883
87MP0002254_reproductive_system_inflammat1.01787277
88MP0001853_heart_inflammation1.01577437
89MP0005387_immune_system_phenotype1.01364664
90MP0001790_abnormal_immune_system1.01364664
91MP0001188_hyperpigmentation1.01073524
92MP0005025_abnormal_response_to1.00879739
93MP0005464_abnormal_platelet_physiology1.00265388
94MP0002419_abnormal_innate_immunity0.99402572
95MP0005389_reproductive_system_phenotype0.98336083
96MP0005636_abnormal_mineral_homeostasis0.98200616
97MP0001800_abnormal_humoral_immune0.98164929
98MP0009765_abnormal_xenobiotic_induced0.97860361
99MP0005084_abnormal_gallbladder_morpholo0.97499079
100MP0003690_abnormal_glial_cell0.97481735
101MP0008004_abnormal_stomach_pH0.96226166
102MP0003787_abnormal_imprinting0.96108173
103MP0002998_abnormal_bone_remodeling0.95498371
104MP0000604_amyloidosis0.95480044
105MP0003436_decreased_susceptibility_to0.95063153
106MP0005670_abnormal_white_adipose0.94727384
107MP0005174_abnormal_tail_pigmentation0.93843276
108MP0005058_abnormal_lysosome_morphology0.93434850
109MP0002006_tumorigenesis0.93398716
110MP0004043_abnormal_pH_regulation0.92556706
111MP0002722_abnormal_immune_system0.92383209
112MP0002429_abnormal_blood_cell0.92219657
113MP0005166_decreased_susceptibility_to0.91858114
114MP0010386_abnormal_urinary_bladder0.91437238
115MP0003136_yellow_coat_color0.91274482
116MP0008872_abnormal_physiological_respon0.90633560
117MP0002136_abnormal_kidney_physiology0.90467208
118MP0000678_abnormal_parathyroid_gland0.90164986
119MP0009763_increased_sensitivity_to0.89466366
120MP0001119_abnormal_female_reproductive0.88705390
121MP0004947_skin_inflammation0.88614186
122MP0001968_abnormal_touch/_nociception0.87979570
123MP0002723_abnormal_immune_serum0.87418842
124MP0003633_abnormal_nervous_system0.86804695
125MP0005000_abnormal_immune_tolerance0.85938414
126MP0005584_abnormal_enzyme/coenzyme_acti0.85257601
127MP0004147_increased_porphyrin_level0.84462969
128MP0002909_abnormal_adrenal_gland0.83685059
129MP0002928_abnormal_bile_duct0.82922857
130MP0001845_abnormal_inflammatory_respons0.82806475
131MP0006082_CNS_inflammation0.82241084
132MP0002168_other_aberrant_phenotype0.81933528
133MP0000343_altered_response_to0.81460385
134MP0003693_abnormal_embryo_hatching0.80891631
135MP0001919_abnormal_reproductive_system0.79722051
136MP0008877_abnormal_DNA_methylation0.79680428
137MP0000703_abnormal_thymus_morphology0.78744475
138MP0000372_irregular_coat_pigmentation0.78183471
139MP0003879_abnormal_hair_cell0.77968782
140MP0001186_pigmentation_phenotype0.77376366
141MP0002452_abnormal_antigen_presenting0.77129977
142MP0000598_abnormal_liver_morphology0.75013416
143MP0008007_abnormal_cellular_replicative0.74446633
144MP0002396_abnormal_hematopoietic_system0.71735980
145MP0001756_abnormal_urination0.70430568
146MP0003638_abnormal_response/metabolism_0.70095276
147MP0003763_abnormal_thymus_physiology0.69277774
148MP0006036_abnormal_mitochondrial_physio0.69208732
149MP0002638_abnormal_pupillary_reflex0.68731395
150MP0005395_other_phenotype0.67048646
151MP0009642_abnormal_blood_homeostasis0.66714644
152MP0000689_abnormal_spleen_morphology0.66669818
153MP0008260_abnormal_autophagy0.66182454
154MP0001819_abnormal_immune_cell0.62454944

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.57263717
2Prolonged partial thromboplastin time (HP:0003645)4.01351714
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86419940
4Intrahepatic cholestasis (HP:0001406)3.77846022
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.70463668
6Abnormality of pyrimidine metabolism (HP:0004353)3.67045466
7Joint hemorrhage (HP:0005261)3.48039063
8Renal cortical cysts (HP:0000803)3.34348845
9Elevated erythrocyte sedimentation rate (HP:0003565)3.26281538
10Abnormality of macrophages (HP:0004311)3.24729729
11Prolonged bleeding time (HP:0003010)3.23825945
12Hypobetalipoproteinemia (HP:0003563)3.15825486
13Proximal tubulopathy (HP:0000114)3.15467734
14T lymphocytopenia (HP:0005403)3.12032798
15Conjugated hyperbilirubinemia (HP:0002908)3.10737759
16Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09282695
17Hyperglycinuria (HP:0003108)3.05830362
18Abnormality of T cell number (HP:0011839)3.04125746
19Hyperglycinemia (HP:0002154)3.01007824
20Reduced antithrombin III activity (HP:0001976)3.00627147
21Hematochezia (HP:0002573)2.98971187
223-Methylglutaconic aciduria (HP:0003535)2.98709324
23Abnormality of methionine metabolism (HP:0010901)2.97773145
24Myositis (HP:0100614)2.94735831
25Parakeratosis (HP:0001036)2.92155390
26Abnormality of serum amino acid levels (HP:0003112)2.88147758
27Episodic fever (HP:0001954)2.79857900
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79036947
29Abnormality of the renal collecting system (HP:0004742)2.74145579
30Retrobulbar optic neuritis (HP:0100654)2.73082500
31Optic neuritis (HP:0100653)2.73082500
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71162559
33Duplicated collecting system (HP:0000081)2.70952151
34IgG deficiency (HP:0004315)2.69908930
35Abnormality of glycine metabolism (HP:0010895)2.69035033
36Abnormality of serine family amino acid metabolism (HP:0010894)2.69035033
37Abnormal biliary tract physiology (HP:0012439)2.68718409
38Bile duct proliferation (HP:0001408)2.68718409
39Chronic hepatic failure (HP:0100626)2.66999078
40Increased circulating renin level (HP:0000848)2.65122042
41Petechiae (HP:0000967)2.64870286
42Eczematoid dermatitis (HP:0000976)2.63370186
43Orchitis (HP:0100796)2.60363758
44Epistaxis (HP:0000421)2.60002489
45Hyperammonemia (HP:0001987)2.57154093
46Decreased circulating renin level (HP:0003351)2.53679884
47Pulmonary embolism (HP:0002204)2.50912263
48Autoimmune hemolytic anemia (HP:0001890)2.50457605
49Vasculitis (HP:0002633)2.50234133
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.50062346
51Pulmonary infiltrates (HP:0002113)2.49165582
52Abnormality of fatty-acid metabolism (HP:0004359)2.48966977
53Recurrent skin infections (HP:0001581)2.47514935
54Papilledema (HP:0001085)2.46976025
55Gingival bleeding (HP:0000225)2.46456533
56Chronic diarrhea (HP:0002028)2.44683433
57Chromsome breakage (HP:0040012)2.44568601
58Fat malabsorption (HP:0002630)2.44280157
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42346071
60Abnormality of polysaccharide metabolism (HP:0011012)2.42346071
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42346071
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.42282869
63Abnormality of T cells (HP:0002843)2.41930903
64Prolonged neonatal jaundice (HP:0006579)2.41518832
65Hemoptysis (HP:0002105)2.41166311
66Purpura (HP:0000979)2.40831380
67Generalized aminoaciduria (HP:0002909)2.39957618
68Enlarged kidneys (HP:0000105)2.38312613
69Gastrointestinal infarctions (HP:0005244)2.36033406
70Abnormality of nucleobase metabolism (HP:0010932)2.35647864
71Recurrent bacterial skin infections (HP:0005406)2.35415659
72Spontaneous hematomas (HP:0007420)2.35165022
73Recurrent abscess formation (HP:0002722)2.34639648
74Type I transferrin isoform profile (HP:0003642)2.34060489
75Abnormality of liposaccharide metabolism (HP:0010968)2.33424007
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.33424007
77Abnormality of glycolipid metabolism (HP:0010969)2.33424007
78Dysostosis multiplex (HP:0000943)2.32356619
79Increased CSF protein (HP:0002922)2.31986513
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31696905
81Urinary glycosaminoglycan excretion (HP:0003541)2.28572072
82Mucopolysacchariduria (HP:0008155)2.28572072
83Joint swelling (HP:0001386)2.27662708
84Thyroiditis (HP:0100646)2.24313071
85Hyperlipoproteinemia (HP:0010980)2.23923600
86Xanthomatosis (HP:0000991)2.22364874
87Decreased central vision (HP:0007663)2.21898310
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21583041
89Increased IgM level (HP:0003496)2.21194969
90Steatorrhea (HP:0002570)2.20343478
91Ketoacidosis (HP:0001993)2.20125060
92Metaphyseal dysplasia (HP:0100255)2.18281147
93Recurrent fungal infections (HP:0002841)2.17575284
94Deep venous thrombosis (HP:0002625)2.17033241
95Dicarboxylic aciduria (HP:0003215)2.15463214
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15463214
97Lethargy (HP:0001254)2.15436416
98Abnormality of urine glucose concentration (HP:0011016)2.14512173
99Glycosuria (HP:0003076)2.14512173
100Abnormality of the renal cortex (HP:0011035)2.14506749
101Fair hair (HP:0002286)2.14240812
102Chronic obstructive pulmonary disease (HP:0006510)2.13751537
103Obstructive lung disease (HP:0006536)2.13751537
104Renal Fanconi syndrome (HP:0001994)2.13305692
105Erythroderma (HP:0001019)2.12225861
106Microvesicular hepatic steatosis (HP:0001414)2.12082184
107Pancreatic cysts (HP:0001737)2.11658365
108Osteomalacia (HP:0002749)2.11533186
109Abnormality of renal resorption (HP:0011038)2.11230936
110Pustule (HP:0200039)2.11219460
111Meningitis (HP:0001287)2.10863386
112Gangrene (HP:0100758)2.09656454
113Recurrent cutaneous fungal infections (HP:0011370)2.07428831
114Chronic mucocutaneous candidiasis (HP:0002728)2.07428831
115Abnormality of the intrinsic pathway (HP:0010989)2.07338615
116Alkalosis (HP:0001948)2.04868166
117Pancreatic fibrosis (HP:0100732)2.02940972
118Abnormality of the common coagulation pathway (HP:0010990)2.01073449
119Alopecia of scalp (HP:0002293)2.00640789
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99777942
121Hyperbilirubinemia (HP:0002904)1.99048430
122Abnormality of transition element cation homeostasis (HP:0011030)1.98062751
123Dyschromatopsia (HP:0007641)1.97411094
124Severe combined immunodeficiency (HP:0004430)1.96731145
125Cerebral edema (HP:0002181)1.96508924
126Abnormality of T cell physiology (HP:0011840)1.95789783
127Renal tubular acidosis (HP:0001947)1.94905862
128Complement deficiency (HP:0004431)1.94504203
129True hermaphroditism (HP:0010459)1.94111052
130Delayed CNS myelination (HP:0002188)1.93457005
131Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93136788
132Renal tubular dysfunction (HP:0000124)1.92193490
133Abnormality of iron homeostasis (HP:0011031)1.91329898
134Hypolipoproteinemia (HP:0010981)1.91080480
135Systemic lupus erythematosus (HP:0002725)1.90774157
136Metabolic acidosis (HP:0001942)1.90382701
137Chest pain (HP:0100749)1.89889327
138Mutism (HP:0002300)1.89379294
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88811153
140Abnormality of alanine metabolism (HP:0010916)1.88811153
141Hyperalaninemia (HP:0003348)1.88811153
142Keratoconjunctivitis (HP:0001096)1.86317345
143Sensory axonal neuropathy (HP:0003390)1.85780399
144Abnormality of the prostate (HP:0008775)1.85072303
145Abnormality of secondary sexual hair (HP:0009888)1.85065104
146Abnormality of the axillary hair (HP:0100134)1.85065104
147Prostate neoplasm (HP:0100787)1.84976311
148Keratoconjunctivitis sicca (HP:0001097)1.84751748
149Leukocytosis (HP:0001974)1.84514866
150Ketosis (HP:0001946)1.84335660
151Hyperactive renin-angiotensin system (HP:0000841)1.83681869
152Recurrent gram-negative bacterial infections (HP:0005420)1.83601662
153Elevated hepatic transaminases (HP:0002910)1.83422916
154Pancytopenia (HP:0001876)1.82460366
155Alveolar cell carcinoma (HP:0006519)1.82106899
156Progressive neurologic deterioration (HP:0002344)1.81376079
157Abnormality of renin-angiotensin system (HP:0000847)1.81032535
158Cheilitis (HP:0100825)1.80611804
159Vacuolated lymphocytes (HP:0001922)1.80303242
160Ventricular fibrillation (HP:0001663)1.79210293
161Encephalitis (HP:0002383)1.79064167
162Epidermoid cyst (HP:0200040)1.78186469
163Bilateral sensorineural hearing impairment (HP:0008619)1.77432485
164Malnutrition (HP:0004395)1.76419928
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75848319
166Vascular calcification (HP:0004934)1.75461536
167Mediastinal lymphadenopathy (HP:0100721)1.74819836
168Granulocytopenia (HP:0001913)1.74537977
169Hypergonadotropic hypogonadism (HP:0000815)1.74417015
170Nausea (HP:0002018)1.74281575
171Opisthotonus (HP:0002179)1.74153030
172Tetany (HP:0001281)1.73942929
173Abnormality of macular pigmentation (HP:0008002)1.73851632
174Recurrent bronchitis (HP:0002837)1.73312696
175Birth length less than 3rd percentile (HP:0003561)1.73298474
176Spontaneous abortion (HP:0005268)1.73232344
177Arterial thrombosis (HP:0004420)1.73079902
178Lymphopenia (HP:0001888)1.72539128
179Recurrent sinusitis (HP:0011108)1.72298053
180Acute hepatic failure (HP:0006554)1.72267012
181Type 2 muscle fiber atrophy (HP:0003554)1.72195383
182Hypothermia (HP:0002045)1.71442789
183Hypoglycemic coma (HP:0001325)1.70802870
184Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70279232
185Abnormal drinking behavior (HP:0030082)1.68209733
186Polydipsia (HP:0001959)1.68209733
187Acne (HP:0001061)1.67455814
188Abnormality of eosinophils (HP:0001879)1.66953365
189Hypoalbuminemia (HP:0003073)1.66006504
190Abnormal albumin level (HP:0012116)1.66006504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.88567601
2ZAK3.39007814
3IRAK43.30877597
4FRK3.07867509
5STK162.98826989
6SIK32.89195567
7MAP3K142.72468250
8PLK42.34748421
9CAMKK22.19794544
10FES2.07320311
11RIPK42.03281465
12TXK1.98728999
13VRK11.93463992
14IRAK21.80074001
15IRAK11.75874489
16ZAP701.73878039
17GRK61.73005306
18ITK1.71458428
19EPHA21.67053650
20BMPR1B1.66759840
21CASK1.65815426
22BCKDK1.60609839
23STK38L1.55292925
24JAK11.54648356
25CSK1.50707937
26ADRBK21.50670553
27SRPK11.48825121
28CSF1R1.43533230
29PINK11.41145209
30TNIK1.38035107
31TAOK31.35767247
32EIF2AK21.35633727
33IKBKB1.28847050
34BMPR21.28724727
35WEE11.27899427
36TYK21.27822557
37BUB11.25558814
38PBK1.24343221
39LCK1.23903587
40EIF2AK31.23267454
41PIK3CG1.21420470
42TEC1.21291726
43PTK2B1.20739357
44AKT31.19744894
45KDR1.18854982
46NME21.18510679
47IKBKE1.18482006
48DAPK21.18390764
49NLK1.15118504
50MAP3K131.14821331
51PRKCQ1.12820996
52NUAK11.08590497
53INSRR1.02978378
54NEK61.02302476
55MAP3K121.01764138
56ACVR1B1.00216635
57HCK0.95417710
58MATK0.94718749
59FGR0.93953341
60MYLK0.92048207
61GRK10.91102531
62MAPKAPK30.91054352
63NEK90.91037574
64SIK10.90593095
65TTK0.89001264
66GRK70.88034366
67JAK30.86971467
68JAK20.85171751
69CDK30.84749745
70CDK80.83820805
71YES10.83210568
72MAP3K110.81998791
73WNK30.81621414
74MAP3K30.81371433
75MST40.80998133
76ERN10.80745278
77PDK10.80580162
78TIE10.79934585
79OXSR10.79764578
80PRPF4B0.79590064
81MAPK150.79247773
82CAMKK10.79097932
83FER0.78653094
84BLK0.78592996
85MAP3K10.78365823
86GRK50.72372178
87TSSK60.72274956
88EIF2AK10.70797217
89PAK30.70132244
90EPHA30.69744067
91ADRBK10.69516565
92ATR0.68049836
93BTK0.67426205
94MAP3K40.66808665
95CHUK0.66364606
96FGFR30.65952072
97PLK30.65515939
98SGK20.64694052
99MKNK20.64214012
100PRKCH0.63108519
101TRPM70.62404182
102ERBB30.62049472
103TNK20.61605714
104MARK30.61327249
105EPHB10.60405076
106KIT0.59921528
107LYN0.59878641
108FGFR40.59835952
109MUSK0.59706839
110PIM20.58780820
111TGFBR20.58750792
112MKNK10.57916747
113CDK70.57726594
114TAOK20.57600725
115BRSK20.57364824
116STK390.56560343
117RPS6KA50.56485029
118MAP2K30.55877796
119MAPK120.55578769
120NEK10.55521714
121TBK10.51237760
122SIK20.50825200
123MAP3K90.50696883
124LATS10.50094432
125IGF1R0.49862721
126ABL20.49322233
127MAPK70.49240477
128CSNK2A10.48747012
129PIM10.48615698
130MAP4K10.48281187
131PRKCE0.47427580
132PRKD20.47358823
133MAP3K60.47283011
134STK100.47021897
135CLK10.46471032
136PRKCD0.46322038
137MST1R0.45912639
138MAP2K60.45423972
139PRKAA20.44411746
140PLK10.44278294
141PHKG10.43697268
142PHKG20.43697268
143MAP3K20.43008024
144CHEK20.41872387
145MAPK110.41626282
146HIPK20.41093577
147PRKCA0.40571540
148ABL10.40116918
149MAPK40.40033250
150SYK0.39974741
151PRKCG0.39601419
152FLT30.39400407
153DYRK30.39012591
154TAOK10.37290142
155MAPK130.36182369
156FYN0.35952861
157MAP2K70.35828175
158CAMK10.35193685
159MOS0.34826502

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.01139622
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76280875
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54039797
4Autoimmune thyroid disease_Homo sapiens_hsa053202.50821669
5Type I diabetes mellitus_Homo sapiens_hsa049402.45811504
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.28182053
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23887865
8Peroxisome_Homo sapiens_hsa041462.20526012
9Histidine metabolism_Homo sapiens_hsa003402.13000599
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12594363
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.12345927
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10906862
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06281819
14Retinol metabolism_Homo sapiens_hsa008302.03217547
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00183005
16Tryptophan metabolism_Homo sapiens_hsa003801.98207002
17Chemical carcinogenesis_Homo sapiens_hsa052041.95300036
18Hematopoietic cell lineage_Homo sapiens_hsa046401.87029154
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.85521871
20Complement and coagulation cascades_Homo sapiens_hsa046101.78155577
21T cell receptor signaling pathway_Homo sapiens_hsa046601.74342361
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74172498
23Rheumatoid arthritis_Homo sapiens_hsa053231.68536739
24Asthma_Homo sapiens_hsa053101.65634242
25Staphylococcus aureus infection_Homo sapiens_hsa051501.65211173
26beta-Alanine metabolism_Homo sapiens_hsa004101.64260145
27Fatty acid elongation_Homo sapiens_hsa000621.63851629
28Arginine biosynthesis_Homo sapiens_hsa002201.62609215
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.62390968
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61241581
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61149753
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60728854
33One carbon pool by folate_Homo sapiens_hsa006701.60301781
34Folate biosynthesis_Homo sapiens_hsa007901.59207272
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52666726
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51558986
37Antigen processing and presentation_Homo sapiens_hsa046121.46802213
38Fatty acid degradation_Homo sapiens_hsa000711.46234129
39RNA polymerase_Homo sapiens_hsa030201.45634489
40Phenylalanine metabolism_Homo sapiens_hsa003601.45630070
41Proteasome_Homo sapiens_hsa030501.44974657
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44346815
43* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40123828
44Osteoclast differentiation_Homo sapiens_hsa043801.37096617
45Vitamin digestion and absorption_Homo sapiens_hsa049771.36914502
46Protein export_Homo sapiens_hsa030601.34560190
47Collecting duct acid secretion_Homo sapiens_hsa049661.33900344
48ABC transporters_Homo sapiens_hsa020101.32171577
49Steroid biosynthesis_Homo sapiens_hsa001001.31335463
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.27209625
51Homologous recombination_Homo sapiens_hsa034401.27094885
52Butanoate metabolism_Homo sapiens_hsa006501.26250873
53Selenocompound metabolism_Homo sapiens_hsa004501.24072238
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22996901
55Propanoate metabolism_Homo sapiens_hsa006401.22247652
56Tyrosine metabolism_Homo sapiens_hsa003501.22217720
57Pyrimidine metabolism_Homo sapiens_hsa002401.21650110
58Leishmaniasis_Homo sapiens_hsa051401.19947241
59Arginine and proline metabolism_Homo sapiens_hsa003301.19944276
60DNA replication_Homo sapiens_hsa030301.16030276
61Glutathione metabolism_Homo sapiens_hsa004801.14541856
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13889181
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.13831797
64NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08390391
65Starch and sucrose metabolism_Homo sapiens_hsa005001.08039120
66Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03545816
67Fanconi anemia pathway_Homo sapiens_hsa034601.02191831
68Lysosome_Homo sapiens_hsa041421.00838546
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98608612
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.98501566
71Pertussis_Homo sapiens_hsa051330.97392436
72Mismatch repair_Homo sapiens_hsa034300.94662139
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93313445
74Renin secretion_Homo sapiens_hsa049240.93026559
75PPAR signaling pathway_Homo sapiens_hsa033200.91987130
76Arachidonic acid metabolism_Homo sapiens_hsa005900.91915738
77Fatty acid metabolism_Homo sapiens_hsa012120.91812438
78Platelet activation_Homo sapiens_hsa046110.89724824
79Tuberculosis_Homo sapiens_hsa051520.89392882
80Chemokine signaling pathway_Homo sapiens_hsa040620.88737376
81Ribosome_Homo sapiens_hsa030100.88618091
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.88325886
83Basal transcription factors_Homo sapiens_hsa030220.87462565
84Sulfur metabolism_Homo sapiens_hsa009200.87028457
85Malaria_Homo sapiens_hsa051440.85422465
86Sulfur relay system_Homo sapiens_hsa041220.85197698
87Caffeine metabolism_Homo sapiens_hsa002320.84742883
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.83983668
89* Metabolic pathways_Homo sapiens_hsa011000.79712598
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79580696
91Vitamin B6 metabolism_Homo sapiens_hsa007500.79149121
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75975686
93Legionellosis_Homo sapiens_hsa051340.74754530
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74296541
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.72177865
96Linoleic acid metabolism_Homo sapiens_hsa005910.71988195
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71395641
98Pyruvate metabolism_Homo sapiens_hsa006200.71028141
99Primary immunodeficiency_Homo sapiens_hsa053400.70718610
100Phagosome_Homo sapiens_hsa041450.70598941
101Phototransduction_Homo sapiens_hsa047440.69661810
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69360237
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67104032
104Viral myocarditis_Homo sapiens_hsa054160.64934372
105Influenza A_Homo sapiens_hsa051640.64693445
106Morphine addiction_Homo sapiens_hsa050320.64673081
107African trypanosomiasis_Homo sapiens_hsa051430.64275155
108Purine metabolism_Homo sapiens_hsa002300.64179129
109Mineral absorption_Homo sapiens_hsa049780.63569113
110Pentose phosphate pathway_Homo sapiens_hsa000300.62592491
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62549366
112Serotonergic synapse_Homo sapiens_hsa047260.61164936
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60514585
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59875078
115Base excision repair_Homo sapiens_hsa034100.59389745
116Oxidative phosphorylation_Homo sapiens_hsa001900.58820757
117TNF signaling pathway_Homo sapiens_hsa046680.58697842
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58528785
119Nitrogen metabolism_Homo sapiens_hsa009100.58378828
120Nucleotide excision repair_Homo sapiens_hsa034200.57020848
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56531717
122Regulation of autophagy_Homo sapiens_hsa041400.56074211
123B cell receptor signaling pathway_Homo sapiens_hsa046620.56042713
124Insulin secretion_Homo sapiens_hsa049110.55255071
125Circadian rhythm_Homo sapiens_hsa047100.55073303
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54739916
127Non-homologous end-joining_Homo sapiens_hsa034500.54045453
128Ether lipid metabolism_Homo sapiens_hsa005650.49885213
129Other glycan degradation_Homo sapiens_hsa005110.47911537
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.47620558
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46957991
132Endocytosis_Homo sapiens_hsa041440.46333761
133Amphetamine addiction_Homo sapiens_hsa050310.45172641
134Herpes simplex infection_Homo sapiens_hsa051680.44913319
135Shigellosis_Homo sapiens_hsa051310.44741940
136Biosynthesis of amino acids_Homo sapiens_hsa012300.44562757
137RNA degradation_Homo sapiens_hsa030180.43579080
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.42703851
139Toxoplasmosis_Homo sapiens_hsa051450.42225493
140Sphingolipid metabolism_Homo sapiens_hsa006000.39472610
141Lysine degradation_Homo sapiens_hsa003100.37867191
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37622674
143Bile secretion_Homo sapiens_hsa049760.37603058
144Allograft rejection_Homo sapiens_hsa053300.36815315
145Carbon metabolism_Homo sapiens_hsa012000.36106556
146Fat digestion and absorption_Homo sapiens_hsa049750.34845448
147Glycerolipid metabolism_Homo sapiens_hsa005610.34521877
148Graft-versus-host disease_Homo sapiens_hsa053320.34329424
149Measles_Homo sapiens_hsa051620.32133562
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32030510

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