NMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.46035449
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.95238368
3ATP synthesis coupled proton transport (GO:0015986)5.95238368
4DNA unwinding involved in DNA replication (GO:0006268)5.22352709
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04841251
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.98291964
7vocalization behavior (GO:0071625)4.82627001
8nuclear pore complex assembly (GO:0051292)4.61240597
9respiratory electron transport chain (GO:0022904)4.60160257
10regulation of translational fidelity (GO:0006450)4.54395310
11electron transport chain (GO:0022900)4.45918945
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.43600932
13mitotic chromosome condensation (GO:0007076)4.38072696
14synaptic vesicle exocytosis (GO:0016079)4.31347884
15neuronal action potential propagation (GO:0019227)4.27604171
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27061911
17Golgi transport vesicle coating (GO:0048200)4.20337544
18COPI coating of Golgi vesicle (GO:0048205)4.20337544
19heterochromatin organization (GO:0070828)4.17110890
20proline biosynthetic process (GO:0006561)4.08688168
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02712952
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.99535412
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97193598
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.97128874
25locomotory exploration behavior (GO:0035641)3.84685602
26maturation of SSU-rRNA (GO:0030490)3.84030999
27neuron cell-cell adhesion (GO:0007158)3.82250430
28ATP biosynthetic process (GO:0006754)3.81728296
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.65197851
30protein complex localization (GO:0031503)3.64199130
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63199869
32cell migration in hindbrain (GO:0021535)3.62932931
33cell-substrate adherens junction assembly (GO:0007045)3.62884763
34focal adhesion assembly (GO:0048041)3.62884763
35energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.62633610
36ATP hydrolysis coupled proton transport (GO:0015991)3.62633610
37protein localization to synapse (GO:0035418)3.62077253
38cellular protein complex localization (GO:0034629)3.60165081
39nuclear pore organization (GO:0006999)3.60021945
40glutamate receptor signaling pathway (GO:0007215)3.57881639
41adherens junction assembly (GO:0034333)3.56766297
42glutamate secretion (GO:0014047)3.56719556
43regulation of neuronal synaptic plasticity (GO:0048168)3.55050606
44regulation of glutamate receptor signaling pathway (GO:1900449)3.49389357
45transmission of nerve impulse (GO:0019226)3.48405884
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.44824169
47regulation of glutamate secretion (GO:0014048)3.44004427
48formation of translation preinitiation complex (GO:0001731)3.43802283
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43662113
50regulation of protein kinase A signaling (GO:0010738)3.43510863
51synaptic vesicle maturation (GO:0016188)3.43384035
52regulation of early endosome to late endosome transport (GO:2000641)3.43249604
53mitotic sister chromatid segregation (GO:0000070)3.40874117
54translational termination (GO:0006415)3.37364546
55hydrogen ion transmembrane transport (GO:1902600)3.36187175
56neuron-neuron synaptic transmission (GO:0007270)3.34565822
57neuron recognition (GO:0008038)3.33734148
58regulation of dendritic spine morphogenesis (GO:0061001)3.31143402
59ribosomal small subunit biogenesis (GO:0042274)3.30157025
60protein retention in ER lumen (GO:0006621)3.28204274
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26862382
62cytoskeletal anchoring at plasma membrane (GO:0007016)3.26012261
63synaptic transmission, glutamatergic (GO:0035249)3.25865386
64negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.24734883
65negative regulation of microtubule polymerization (GO:0031115)3.24001450
66exploration behavior (GO:0035640)3.23463221
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22319594
68regulation of synaptic plasticity (GO:0048167)3.20692564
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.19779163
70proline transport (GO:0015824)3.17695185
71pore complex assembly (GO:0046931)3.17306912
72regulation of RNA export from nucleus (GO:0046831)3.16260323
73cell-substrate junction assembly (GO:0007044)3.15990745
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15949417
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14983304
76negative regulation of amino acid transport (GO:0051956)3.14680505
77proline metabolic process (GO:0006560)3.12424093
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11732327
79protein localization to endosome (GO:0036010)3.11480409
80dendritic spine morphogenesis (GO:0060997)3.10557108
81regulation of nucleobase-containing compound transport (GO:0032239)3.10436535
82purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09799305
83regulation of postsynaptic membrane potential (GO:0060078)3.08788433
84neurotransmitter secretion (GO:0007269)3.08778826
85regulation of mitotic spindle organization (GO:0060236)3.08773010
86protein export from nucleus (GO:0006611)3.08499045
87ribonucleoprotein complex biogenesis (GO:0022613)3.07197900
88long-term memory (GO:0007616)3.03824164
89vesicle transport along microtubule (GO:0047496)3.03197761
90positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02936461
91calcium-mediated signaling using intracellular calcium source (GO:0035584)3.00653326
92chromosome condensation (GO:0030261)3.00094493
93DNA strand elongation involved in DNA replication (GO:0006271)2.99432637
94peptidyl-arginine omega-N-methylation (GO:0035247)2.99101678
95regulation of vesicle fusion (GO:0031338)2.97055982
96sister chromatid segregation (GO:0000819)2.95882601
97cellular protein complex disassembly (GO:0043624)2.95493990
98positive regulation of membrane potential (GO:0045838)2.95361703
99regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.94428645
100cellular potassium ion homeostasis (GO:0030007)2.93703190
101activation of Rac GTPase activity (GO:0032863)2.93614120
102pentose-phosphate shunt (GO:0006098)2.93003935
103planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92848770
104dendritic spine organization (GO:0097061)2.92576091
105DNA strand elongation (GO:0022616)2.92203647
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91687104
107folic acid metabolic process (GO:0046655)2.90490265
108positive regulation of synapse maturation (GO:0090129)2.89679726
109protein neddylation (GO:0045116)2.89481528
110regulation of synaptic vesicle exocytosis (GO:2000300)2.89278742
111neuromuscular process controlling balance (GO:0050885)2.87643011
112mating behavior (GO:0007617)2.87438386
113apoptotic process involved in morphogenesis (GO:0060561)2.87201207
114translational elongation (GO:0006414)2.87181450
115viral life cycle (GO:0019058)2.86142787
116DNA replication initiation (GO:0006270)2.85739385
117sodium ion export (GO:0071436)2.85644350
118synaptic vesicle endocytosis (GO:0048488)2.85352896
119cellular response to epidermal growth factor stimulus (GO:0071364)2.84688285
120fear response (GO:0042596)2.84621306
121positive regulation of response to oxidative stress (GO:1902884)2.84326309
122positive regulation of cellular response to oxidative stress (GO:1900409)2.84326309
123protein complex disassembly (GO:0043241)2.83540487
124regulation of cholesterol homeostasis (GO:2000188)2.83368211
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83064116
126nucleobase-containing small molecule interconversion (GO:0015949)2.82848550
127proton transport (GO:0015992)2.82626176
128response to histamine (GO:0034776)2.81510297
129protein localization to chromosome, centromeric region (GO:0071459)2.80627048
130regulation of dendritic spine development (GO:0060998)2.80433946
131long term synaptic depression (GO:0060292)2.80069866
132regulation of translational termination (GO:0006449)2.79099252
133regulation of synapse structural plasticity (GO:0051823)2.78928611
134DNA topological change (GO:0006265)2.78790988
135hydrogen transport (GO:0006818)2.77705684
136long-term synaptic potentiation (GO:0060291)2.77026659
137plasma membrane repair (GO:0001778)2.76425489
138neurotransmitter transport (GO:0006836)2.74209949
139behavioral defense response (GO:0002209)2.73753269
140behavioral fear response (GO:0001662)2.73753269
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.73500501
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73481285
143cortical actin cytoskeleton organization (GO:0030866)2.73412701
144chaperone-mediated protein transport (GO:0072321)2.73126069
145ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72581369
146ribosomal large subunit biogenesis (GO:0042273)2.72114901
147substantia nigra development (GO:0021762)2.71942083
148basement membrane organization (GO:0071711)2.69929882
149establishment of integrated proviral latency (GO:0075713)2.69923588
150mitotic nuclear envelope disassembly (GO:0007077)2.69643151
151cerebellar Purkinje cell layer development (GO:0021680)2.69637423
152axonal fasciculation (GO:0007413)2.69610129
153membrane depolarization (GO:0051899)2.69272804
154SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.69077792
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.69037462
156regulation of glucose import in response to insulin stimulus (GO:2001273)2.67869913
157chemosensory behavior (GO:0007635)2.67698854
158mitotic G1 DNA damage checkpoint (GO:0031571)2.66784465
159gamma-aminobutyric acid transport (GO:0015812)2.66666501
160positive regulation of fibroblast migration (GO:0010763)2.66513008
161paraxial mesoderm development (GO:0048339)2.66400189
162viral transcription (GO:0019083)2.66049557
163protein targeting to ER (GO:0045047)2.65576496
164NADH metabolic process (GO:0006734)2.65297433
165regulation of neurotransmitter levels (GO:0001505)2.64557647
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64020615
167cotranslational protein targeting to membrane (GO:0006613)2.61644269
168DNA duplex unwinding (GO:0032508)2.60098244
169membrane disassembly (GO:0030397)2.58998752
170nuclear envelope disassembly (GO:0051081)2.58998752
171mRNA stabilization (GO:0048255)2.58913908
172RNA stabilization (GO:0043489)2.58913908
173establishment of apical/basal cell polarity (GO:0035089)2.57551973
174translational initiation (GO:0006413)2.55908164
175regulation of cholesterol biosynthetic process (GO:0045540)2.55899427
176pinocytosis (GO:0006907)2.55645990
177macromolecular complex disassembly (GO:0032984)2.55514964
178establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54252676
179G1 DNA damage checkpoint (GO:0044783)2.48876412
180positive regulation of nuclease activity (GO:0032075)2.48740560
181activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48709152
182NADPH regeneration (GO:0006740)2.48169314
183urea cycle (GO:0000050)2.47313900
184maternal placenta development (GO:0001893)2.46818251
185response to epidermal growth factor (GO:0070849)2.45518497
186histone arginine methylation (GO:0034969)2.43576533
187protein localization to endoplasmic reticulum (GO:0070972)2.43172035
188regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42890555
189regulation of histone H3-K27 methylation (GO:0061085)2.42191094
190maturation of 5.8S rRNA (GO:0000460)2.41938356
191glucose catabolic process (GO:0006007)2.41249528
192protein localization to kinetochore (GO:0034501)2.37035683
193DNA geometric change (GO:0032392)2.35016067
194negative regulation of erythrocyte differentiation (GO:0045647)2.34657596
195protein carboxylation (GO:0018214)2.33915489
196peptidyl-glutamic acid carboxylation (GO:0017187)2.33915489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59393731
2E2F7_22180533_ChIP-Seq_HELA_Human4.70251722
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.50506377
4* RARB_27405468_Chip-Seq_BRAIN_Mouse3.24183224
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.97268637
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.93157242
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.88193353
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.65161240
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62667516
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57179951
11MYC_22102868_ChIP-Seq_BL_Human2.56035629
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.54269975
13REST_21632747_ChIP-Seq_MESCs_Mouse2.43215286
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40486582
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32974329
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26573532
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25725468
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25143194
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.24986082
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22317089
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20015279
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20015279
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18773831
24VDR_21846776_ChIP-Seq_THP-1_Human2.14296013
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10159012
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08611005
27ZNF263_19887448_ChIP-Seq_K562_Human2.07805068
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07448228
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98961863
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98842071
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98799799
32DROSHA_22980978_ChIP-Seq_HELA_Human1.98242700
33GBX2_23144817_ChIP-Seq_PC3_Human1.97909256
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94569424
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.94466498
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93571873
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91044380
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90069210
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88707624
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87928138
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87928138
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87928138
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86051481
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.83223459
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.81025037
46XRN2_22483619_ChIP-Seq_HELA_Human1.80718669
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80700933
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80083436
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77623200
50RACK7_27058665_Chip-Seq_MCF-7_Human1.75926790
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73559499
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73532712
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73428815
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72036345
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70870789
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68013997
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67574866
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.67017770
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66098073
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63618299
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62936131
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62773117
63CLOCK_20551151_ChIP-Seq_293T_Human1.62771536
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62088760
65ZNF274_21170338_ChIP-Seq_K562_Hela1.61564942
66VDR_22108803_ChIP-Seq_LS180_Human1.59742845
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55953462
68AR_21909140_ChIP-Seq_LNCAP_Human1.51231575
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50707791
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50315122
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49368854
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48901581
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48452120
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47794471
75* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46160070
76TCF7_22412390_ChIP-Seq_EML_Mouse1.45140002
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44483398
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44454968
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42286212
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.42033072
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40732947
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40054189
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39354426
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38451760
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37234270
86* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35961405
87KDM2B_26808549_Chip-Seq_K562_Human1.35579456
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35195041
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34618122
90NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31605298
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31401159
92KDM2B_26808549_Chip-Seq_DND41_Human1.30239168
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29945570
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29736114
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28022975
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26407889
97TP53_16413492_ChIP-PET_HCT116_Human1.25918543
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25771675
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23180786
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23106128
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22065384
102ATF3_27146783_Chip-Seq_COLON_Human1.21786757
103P68_20966046_ChIP-Seq_HELA_Human1.21141117
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.20460829
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18909058
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18774712
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17746708
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17424993
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15295012
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.14322904
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14020606
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13838237
113* NCOR1_26117541_ChIP-Seq_K562_Human1.13708119
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12867877
115SA1_27219007_Chip-Seq_ERYTHROID_Human1.12634816
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12264248
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11728739
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10429199
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10042216
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09587834
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08894526
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07613196
123* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07120528
124FUS_26573619_Chip-Seq_HEK293_Human1.07097536
125ETS1_20019798_ChIP-Seq_JURKAT_Human1.06955985
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06306401
127TP53_18474530_ChIP-ChIP_U2OS_Human1.04087547
128* SMC4_20622854_ChIP-Seq_HELA_Human1.03724687
129DCP1A_22483619_ChIP-Seq_HELA_Human1.03605836
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.03154143
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02878696
132TP53_22127205_ChIP-Seq_IMR90_Human1.02822085
133TP53_20018659_ChIP-ChIP_R1E_Mouse1.01590104
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00973227
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00837661
136MAF_26560356_Chip-Seq_TH1_Human1.00705613
137CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00450073
138LXR_22292898_ChIP-Seq_THP-1_Human0.99977067
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.99882126
140TTF2_22483619_ChIP-Seq_HELA_Human0.99631394
141* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99291924
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99051545
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.98222402
144CTCF_27219007_Chip-Seq_Bcells_Human0.98042432
145CREB1_26743006_Chip-Seq_LNCaP_Human0.97950432
146ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97570132
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96313723
148* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95913651
149TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95177368
150PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94427775
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93999940
152MAF_26560356_Chip-Seq_TH2_Human0.93397578
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92927663
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92857433
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.92816817
156AR_21572438_ChIP-Seq_LNCaP_Human0.92568006
157SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91762232
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.91753576
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91718467
160BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91519143
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90566114
162SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89919078
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88207840
164MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87718433
165NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85161494
166* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83793669
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81929482
168MYC_18555785_ChIP-Seq_MESCs_Mouse0.81843843
169POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81841885
170TAF15_26573619_Chip-Seq_HEK293_Human0.78271218
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78260198
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78109640
173* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.78092649
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.77397527
175SOX2_16153702_ChIP-ChIP_HESCs_Human0.76402076
176THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76241645
177ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75453134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.12159706
2MP0003705_abnormal_hypodermis_morpholog5.16536711
3MP0003880_abnormal_central_pattern5.13197330
4MP0004270_analgesia4.11117274
5MP0003635_abnormal_synaptic_transmissio3.52567798
6MP0001968_abnormal_touch/_nociception3.32672418
7MP0002736_abnormal_nociception_after3.32282744
8MP0002064_seizures3.15291517
9MP0009745_abnormal_behavioral_response3.10323014
10MP0003111_abnormal_nucleus_morphology2.97893574
11MP0002837_dystrophic_cardiac_calcinosis2.95189777
12MP0001440_abnormal_grooming_behavior2.91616665
13MP0002063_abnormal_learning/memory/cond2.80636225
14MP0002877_abnormal_melanocyte_morpholog2.80120588
15MP0008438_abnormal_cutaneous_collagen2.70435470
16MP0003329_amyloid_beta_deposits2.55531577
17MP0003693_abnormal_embryo_hatching2.51849675
18MP0002272_abnormal_nervous_system2.39933854
19MP0002572_abnormal_emotion/affect_behav2.39161796
20MP0002735_abnormal_chemical_nociception2.39131566
21MP0002734_abnormal_mechanical_nocicepti2.37461302
22MP0004957_abnormal_blastocyst_morpholog2.33316384
23MP0009046_muscle_twitch2.33236669
24MP0005451_abnormal_body_composition2.31562322
25MP0005076_abnormal_cell_differentiation2.27959624
26MP0001501_abnormal_sleep_pattern2.21192046
27MP0001346_abnormal_lacrimal_gland2.20556269
28MP0001849_ear_inflammation2.15399262
29MP0004858_abnormal_nervous_system2.14936440
30MP0002733_abnormal_thermal_nociception2.12750695
31MP0005423_abnormal_somatic_nervous2.06803352
32MP0001730_embryonic_growth_arrest2.03447633
33MP0004272_abnormal_basement_membrane2.00834805
34MP0002254_reproductive_system_inflammat1.99801157
35MP0002089_abnormal_postnatal_growth/wei1.95332651
36MP0005257_abnormal_intraocular_pressure1.94658073
37MP0001970_abnormal_pain_threshold1.93804355
38MP0002822_catalepsy1.89306941
39MP0005623_abnormal_meninges_morphology1.84998877
40MP0003077_abnormal_cell_cycle1.82528849
41MP0010094_abnormal_chromosome_stability1.78775951
42MP0003941_abnormal_skin_development1.74264935
43MP0001905_abnormal_dopamine_level1.69619919
44MP0005409_darkened_coat_color1.66222951
45MP0010352_gastrointestinal_tract_polyps1.66119115
46MP0000350_abnormal_cell_proliferation1.65483391
47MP0008260_abnormal_autophagy1.63668649
48MP0002067_abnormal_sensory_capabilities1.63463803
49MP0001486_abnormal_startle_reflex1.62785146
50MP0003300_gastrointestinal_ulcer1.61801118
51MP0010030_abnormal_orbit_morphology1.56835123
52MP0001529_abnormal_vocalization1.56791889
53MP0009672_abnormal_birth_weight1.54918412
54MP0000604_amyloidosis1.52764117
55MP0008932_abnormal_embryonic_tissue1.52667836
56MP0000678_abnormal_parathyroid_gland1.49744213
57MP0003453_abnormal_keratinocyte_physiol1.49490086
58MP0003690_abnormal_glial_cell1.49154862
59MP0003075_altered_response_to1.48249765
60MP0005023_abnormal_wound_healing1.47678051
61MP0001915_intracranial_hemorrhage1.45719421
62MP0000537_abnormal_urethra_morphology1.44514644
63MP0000003_abnormal_adipose_tissue1.43662056
64MP0004811_abnormal_neuron_physiology1.43484277
65MP0008007_abnormal_cellular_replicative1.42647382
66MP0000751_myopathy1.42466084
67MP0004924_abnormal_behavior1.40363589
68MP0005386_behavior/neurological_phenoty1.40363589
69MP0000858_altered_metastatic_potential1.35470671
70MP0003091_abnormal_cell_migration1.34320373
71* MP0002080_prenatal_lethality1.33253570
72MP0009780_abnormal_chondrocyte_physiolo1.32828169
73MP0002066_abnormal_motor_capabilities/c1.31165809
74MP0004142_abnormal_muscle_tone1.31023588
75MP0002396_abnormal_hematopoietic_system1.30637756
76MP0004145_abnormal_muscle_electrophysio1.30122177
77MP0005501_abnormal_skin_physiology1.28933712
78MP0006276_abnormal_autonomic_nervous1.27978180
79MP0002796_impaired_skin_barrier1.26070770
80MP0000920_abnormal_myelination1.25843231
81MP0009840_abnormal_foam_cell1.25124010
82MP0001672_abnormal_embryogenesis/_devel1.25026190
83MP0005380_embryogenesis_phenotype1.25026190
84MP0000778_abnormal_nervous_system1.23813329
85MP0003984_embryonic_growth_retardation1.21916416
86MP0009379_abnormal_foot_pigmentation1.21042777
87MP0000955_abnormal_spinal_cord1.20310575
88MP0009333_abnormal_splenocyte_physiolog1.18133940
89MP0002060_abnormal_skin_morphology1.18056769
90MP0002184_abnormal_innervation1.16841433
91MP0008569_lethality_at_weaning1.14332045
92MP0002882_abnormal_neuron_morphology1.14018461
93MP0001697_abnormal_embryo_size1.13848811
94MP0000733_abnormal_muscle_development1.13298289
95MP0002088_abnormal_embryonic_growth/wei1.11974678
96MP0003633_abnormal_nervous_system1.11091967
97MP0003632_abnormal_nervous_system1.11032525
98MP0009053_abnormal_anal_canal1.10924726
99MP0002086_abnormal_extraembryonic_tissu1.10158912
100MP0000747_muscle_weakness1.10109105
101MP0003631_nervous_system_phenotype1.09937796
102MP0002249_abnormal_larynx_morphology1.09879402
103MP0004185_abnormal_adipocyte_glucose1.09353836
104MP0002085_abnormal_embryonic_tissue1.09337352
105MP0003283_abnormal_digestive_organ1.08465929
106MP0008874_decreased_physiological_sensi1.07704679
107MP0002557_abnormal_social/conspecific_i1.06783139
108MP0008872_abnormal_physiological_respon1.06551301
109MP0003634_abnormal_glial_cell1.05612253
110MP0002229_neurodegeneration1.04855482
111MP0002697_abnormal_eye_size1.04050709
112MP0005375_adipose_tissue_phenotype1.02970000
113MP0000013_abnormal_adipose_tissue1.00403734
114MP0003172_abnormal_lysosome_physiology0.99726745
115MP0000762_abnormal_tongue_morphology0.99448758
116MP0005666_abnormal_adipose_tissue0.99074553
117MP0001727_abnormal_embryo_implantation0.98458954
118MP0005621_abnormal_cell_physiology0.97740309
119MP0010307_abnormal_tumor_latency0.95829560
120MP0001661_extended_life_span0.94882432
121MP0004510_myositis0.94604080
122MP0000566_synostosis0.94446177
123MP0000490_abnormal_crypts_of0.94251768
124MP0002152_abnormal_brain_morphology0.94251148
125MP0000750_abnormal_muscle_regeneration0.93796954
126MP0001873_stomach_inflammation0.93039404
127MP0005410_abnormal_fertilization0.92881723
128MP0002084_abnormal_developmental_patter0.91575073
129MP0003942_abnormal_urinary_system0.91388879
130MP0000313_abnormal_cell_death0.90979135
131MP0000428_abnormal_craniofacial_morphol0.90976564
132MP0003879_abnormal_hair_cell0.89888455
133MP0001881_abnormal_mammary_gland0.88207369
134MP0005058_abnormal_lysosome_morphology0.87982378
135MP0010630_abnormal_cardiac_muscle0.86136490
136MP0010234_abnormal_vibrissa_follicle0.85579277
137MP0004484_altered_response_of0.83178299
138MP0004885_abnormal_endolymph0.81963619
139MP0003315_abnormal_perineum_morphology0.80846069
140MP0005165_increased_susceptibility_to0.80686016
141MP0003385_abnormal_body_wall0.79213239
142MP0002909_abnormal_adrenal_gland0.79152232
143MP0004233_abnormal_muscle_weight0.78762701
144MP0002139_abnormal_hepatobiliary_system0.78026195
145MP0004036_abnormal_muscle_relaxation0.77788003
146MP0003137_abnormal_impulse_conducting0.77234448
147MP0003115_abnormal_respiratory_system0.76732873
148MP0003136_yellow_coat_color0.76095091
149MP0004742_abnormal_vestibular_system0.74846902
150MP0004264_abnormal_extraembryonic_tissu0.74151086
151MP0004084_abnormal_cardiac_muscle0.74062965
152MP0005275_abnormal_skin_tensile0.73484378
153MP0002092_abnormal_eye_morphology0.72942976
154MP0001485_abnormal_pinna_reflex0.71524377
155MP0000477_abnormal_intestine_morphology0.71363462
156MP0000534_abnormal_ureter_morphology0.71034174
157MP0004197_abnormal_fetal_growth/weight/0.70848194
158MP0005408_hypopigmentation0.70712308
159MP0004133_heterotaxia0.70679659
160MP0005197_abnormal_uvea_morphology0.70524285
161MP0000759_abnormal_skeletal_muscle0.70387375
162MP0005166_decreased_susceptibility_to0.69771049
163MP0002090_abnormal_vision0.68482016
164MP0002069_abnormal_eating/drinking_beha0.68041107
165MP0005535_abnormal_body_temperature0.67951716
166MP0003045_fibrosis0.67912561
167MP0000579_abnormal_nail_morphology0.67223604
168MP0001348_abnormal_lacrimal_gland0.66158136
169MP0002295_abnormal_pulmonary_circulatio0.66150913
170MP0005384_cellular_phenotype0.66016823
171MP0002269_muscular_atrophy0.65494934
172MP0009931_abnormal_skin_appearance0.65269710
173MP0001963_abnormal_hearing_physiology0.63807731
174MP0004087_abnormal_muscle_fiber0.61399995
175MP0003787_abnormal_imprinting0.60618883
176MP0003566_abnormal_cell_adhesion0.59678297
177MP0002106_abnormal_muscle_physiology0.58242659
178MP0004085_abnormal_heartbeat0.56659261
179MP0003123_paternal_imprinting0.55344877
180MP0004883_abnormal_blood_vessel0.54796199
181MP0001664_abnormal_digestion0.54345034
182MP0002653_abnormal_ependyma_morphology0.53743870
183MP0005620_abnormal_muscle_contractility0.52250174

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.15990069
2Focal motor seizures (HP:0011153)5.30978615
3Cerebral inclusion bodies (HP:0100314)4.71815645
4Acute necrotizing encephalopathy (HP:0006965)4.41522897
5Focal seizures (HP:0007359)4.01441139
6Progressive macrocephaly (HP:0004481)3.87624195
7Neurofibrillary tangles (HP:0002185)3.84340131
8Abnormal mitochondria in muscle tissue (HP:0008316)3.81444661
9Protrusio acetabuli (HP:0003179)3.76445180
10Atonic seizures (HP:0010819)3.70982794
11Hyperacusis (HP:0010780)3.63853707
12Acute encephalopathy (HP:0006846)3.60542882
13Mitochondrial inheritance (HP:0001427)3.54030678
14Supranuclear gaze palsy (HP:0000605)3.52203777
15Visual hallucinations (HP:0002367)3.50271733
16Premature rupture of membranes (HP:0001788)3.28446447
17Abnormality of binocular vision (HP:0011514)3.26918406
18Diplopia (HP:0000651)3.26918406
19Absence seizures (HP:0002121)3.18599412
20Insomnia (HP:0100785)3.10465548
21Dialeptic seizures (HP:0011146)3.07022244
22Delusions (HP:0000746)3.02093101
23Sensory axonal neuropathy (HP:0003390)3.00930449
24Amblyopia (HP:0000646)2.99229614
25Deep venous thrombosis (HP:0002625)2.98233810
26Vertebral compression fractures (HP:0002953)2.90827139
27Achilles tendon contracture (HP:0001771)2.86316794
28Generalized tonic-clonic seizures (HP:0002069)2.83037509
29Increased CSF lactate (HP:0002490)2.79648407
30Testicular atrophy (HP:0000029)2.77107889
31Rapidly progressive (HP:0003678)2.75191824
32Ulnar bowing (HP:0003031)2.73080861
33Increased hepatocellular lipid droplets (HP:0006565)2.69678195
34Global brain atrophy (HP:0002283)2.65208007
35Leukodystrophy (HP:0002415)2.64250264
36Epileptic encephalopathy (HP:0200134)2.63953591
37Abnormality of oral frenula (HP:0000190)2.59259477
38Cerebral edema (HP:0002181)2.59076698
39Increased connective tissue (HP:0009025)2.58892529
40Abnormality of the Achilles tendon (HP:0005109)2.58073349
41Shallow orbits (HP:0000586)2.58022956
42Disproportionate tall stature (HP:0001519)2.57136875
43Hepatocellular necrosis (HP:0001404)2.56329567
44Termporal pattern (HP:0011008)2.55296953
45Insidious onset (HP:0003587)2.55296953
46Sudden death (HP:0001699)2.55040990
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.49490295
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49490295
49Distal lower limb amyotrophy (HP:0008944)2.48518680
50Resting tremor (HP:0002322)2.47327925
51Broad-based gait (HP:0002136)2.46731603
52Respiratory failure (HP:0002878)2.42897775
53Renal duplication (HP:0000075)2.42826062
54Dysmetria (HP:0001310)2.40516263
55Emotional lability (HP:0000712)2.40306859
56Dysautonomia (HP:0002459)2.34581386
57Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.30670459
58Hydroureter (HP:0000072)2.27438036
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27267760
60Athetosis (HP:0002305)2.26735828
61Impaired vibration sensation in the lower limbs (HP:0002166)2.25931140
62Lipid accumulation in hepatocytes (HP:0006561)2.24151577
63Abnormality of the corticospinal tract (HP:0002492)2.21272214
64Flat acetabular roof (HP:0003180)2.20362114
65Overriding aorta (HP:0002623)2.19841626
66Neuronal loss in central nervous system (HP:0002529)2.19343132
67Reticulocytopenia (HP:0001896)2.19182125
68Asymmetry of the thorax (HP:0001555)2.18648137
69Lower limb amyotrophy (HP:0007210)2.12318844
70Hemiparesis (HP:0001269)2.11367785
71Turricephaly (HP:0000262)2.11017877
72Orthostatic hypotension (HP:0001278)2.10680158
73Myotonia (HP:0002486)2.09315113
74Delayed cranial suture closure (HP:0000270)2.08777207
75Hyperventilation (HP:0002883)2.08194690
76Abnormality of the lower motor neuron (HP:0002366)2.07920470
77Progressive muscle weakness (HP:0003323)2.07170605
78Increased nuchal translucency (HP:0010880)2.06907313
79Abnormal autonomic nervous system physiology (HP:0012332)2.06197897
80Optic disc pallor (HP:0000543)2.05327372
81Elfin facies (HP:0004428)2.05276898
82Renal Fanconi syndrome (HP:0001994)2.05006465
83Arnold-Chiari malformation (HP:0002308)2.04208191
84Cholecystitis (HP:0001082)2.03188755
85Abnormal gallbladder physiology (HP:0012438)2.03188755
86Bladder diverticulum (HP:0000015)2.03071795
87Action tremor (HP:0002345)2.01313673
88Selective tooth agenesis (HP:0001592)2.00959973
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.00476070
90Deep palmar crease (HP:0006191)1.97725668
91Fragile skin (HP:0001030)1.97410450
92Spastic gait (HP:0002064)1.97408915
93Missing ribs (HP:0000921)1.95717609
94Coronal craniosynostosis (HP:0004440)1.94510320
95Increased intramyocellular lipid droplets (HP:0012240)1.93637455
96X-linked dominant inheritance (HP:0001423)1.93044041
97Cerebral aneurysm (HP:0004944)1.91339824
98Hyporeflexia of lower limbs (HP:0002600)1.90662684
99Difficulty climbing stairs (HP:0003551)1.90480219
100Cerebral hypomyelination (HP:0006808)1.89862595
101Biconcave vertebral bodies (HP:0004586)1.88424511
102Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88235864
103Cerebral hemorrhage (HP:0001342)1.87780626
104Pointed chin (HP:0000307)1.87566218
105Dysdiadochokinesis (HP:0002075)1.87286635
106Ankyloglossia (HP:0010296)1.87017271
107Back pain (HP:0003418)1.86660649
108Abnormality of reticulocytes (HP:0004312)1.86117217
109Ankle contracture (HP:0006466)1.86015068
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85869764
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85000158
112Akinesia (HP:0002304)1.84984243
113Anxiety (HP:0000739)1.84710863
114Exercise intolerance (HP:0003546)1.84590150
115Axonal loss (HP:0003447)1.83179101
116Adenoma sebaceum (HP:0009720)1.83023598
117Angiofibromas (HP:0010615)1.83023598
118Abnormal ossification of hand bones (HP:0005921)1.81746466
119Personality changes (HP:0000751)1.80894877
120Progressive external ophthalmoplegia (HP:0000590)1.80108349
121Progressive cerebellar ataxia (HP:0002073)1.78798373
122Spinal rigidity (HP:0003306)1.78675300
123Dysmetric saccades (HP:0000641)1.78348510
124Abnormal eating behavior (HP:0100738)1.77972657
125Broad face (HP:0000283)1.77057268
126Hemorrhage of the eye (HP:0011885)1.76809429
127Delayed closure of the anterior fontanelle (HP:0001476)1.76602401
128Trismus (HP:0000211)1.76441757
129Psychosis (HP:0000709)1.75782787
130Spinal cord compression (HP:0002176)1.75550240
131Hemiplegia (HP:0002301)1.73926292
132Spinal cord lesions (HP:0100561)1.73289733
133Syringomyelia (HP:0003396)1.73289733
134Osteolytic defects of the hand bones (HP:0009699)1.73047356
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.73047356
136Partial duplication of the phalanx of hand (HP:0009999)1.73007997
137Short chin (HP:0000331)1.72671474
138Renovascular hypertension (HP:0100817)1.72246621
139Foot dorsiflexor weakness (HP:0009027)1.71786690
140Abnormality of the acetabulum (HP:0003170)1.71345806
141Obstructive sleep apnea (HP:0002870)1.71080077
142Abnormality of carpal bone ossification (HP:0006257)1.70888527
143Reticulocytosis (HP:0001923)1.70454893
144Impaired social interactions (HP:0000735)1.70072106
145Abnormal social behavior (HP:0012433)1.70072106
146Generalized myoclonic seizures (HP:0002123)1.70021281
147Patellar dislocation (HP:0002999)1.69981845
148Pseudobulbar signs (HP:0002200)1.69972366
149Long palpebral fissure (HP:0000637)1.69847617
150Blue sclerae (HP:0000592)1.69512712
151Deviation of the thumb (HP:0009603)1.68932548
152Upper limb muscle weakness (HP:0003484)1.68235247
153Advanced eruption of teeth (HP:0006288)1.67878744
154Abnormality of glycolysis (HP:0004366)1.67809861
155Short nail (HP:0001799)1.67149168
156Duplication of thumb phalanx (HP:0009942)1.67076080
157Depression (HP:0000716)1.66589118
158Truncus arteriosus (HP:0001660)1.66193259
159Fibular aplasia (HP:0002990)1.66162299
160Abnormality of the thoracic spine (HP:0100711)1.65821975
161Poor eye contact (HP:0000817)1.64803214
16211 pairs of ribs (HP:0000878)1.64342078
163Mitral regurgitation (HP:0001653)1.64178391
164Upper limb amyotrophy (HP:0009129)1.64122275
165Distal upper limb amyotrophy (HP:0007149)1.64122275
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63843193
167Urinary bladder sphincter dysfunction (HP:0002839)1.63212434
168Wormian bones (HP:0002645)1.62639426
169Partial duplication of thumb phalanx (HP:0009944)1.60916436
170Abnormality of the distal phalanx of the thumb (HP:0009617)1.60719946
171Flat cornea (HP:0007720)1.59746918
172Bowed forearm bones (HP:0003956)1.59619595
173Bowing of the arm (HP:0006488)1.59619595
174Dilatation of the ascending aorta (HP:0005111)1.59376719
175Abnormality of complement system (HP:0005339)1.58897963
176Persistence of primary teeth (HP:0006335)1.58753852
177Bowel incontinence (HP:0002607)1.58591234
178Abnormality of the tricuspid valve (HP:0001702)1.58132080
179Neonatal death (HP:0003811)1.57884904
180Impaired pain sensation (HP:0007328)1.57587949
181Abnormality of pain sensation (HP:0010832)1.57587949
182Small epiphyses (HP:0010585)1.56874449
183Segmental peripheral demyelination/remyelination (HP:0003481)1.56053402
184Nasolacrimal duct obstruction (HP:0000579)1.55534844
185Increased variability in muscle fiber diameter (HP:0003557)1.55468245
186Annular pancreas (HP:0001734)1.54628788
187Bronchomalacia (HP:0002780)1.54239265
188Metaphyseal cupping (HP:0003021)1.53928093
189Arterial tortuosity (HP:0005116)1.53854570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.26748133
2TRIB33.92273901
3SMG13.84159745
4RIPK43.64343876
5NTRK33.63311242
6PNCK3.60371345
7MAP3K93.45957835
8EEF2K3.17908678
9CDK123.14755112
10PRPF4B2.98132226
11ICK2.94620791
12KSR22.73190719
13ARAF2.50493442
14FGFR42.38100260
15GRK52.35146906
16SIK12.26894181
17NME22.15007711
18ERN12.14118647
19PLK22.13749365
20FGR2.08747100
21MINK11.97311752
22NTRK11.96449344
23IRAK31.94738839
24TLK11.93867506
25PDGFRA1.90017194
26RIPK11.89483012
27PAK61.85936761
28NME11.83417643
29MAP3K41.82482852
30PTK2B1.78927109
31MAP3K21.75643828
32MAP3K101.75626845
33CDC71.75156839
34MAP3K121.66285363
35FES1.64705255
36MST1R1.56860495
37PASK1.45385421
38TESK11.45114885
39DAPK21.41749548
40TTK1.39300025
41MST41.38635500
42LIMK11.29245609
43PDK21.27781862
44MAP2K41.21590030
45DAPK31.20602620
46LATS21.20512971
47STK391.20223229
48CDK141.18482455
49NEK11.17610776
50MTOR1.14909893
51MAP3K81.13709045
52CDK151.11611544
53GRK61.09037382
54MAP3K131.07828289
55GRK71.06326864
56CDK181.05084979
57KSR11.05014766
58MAP2K11.04463096
59MOS1.04243550
60TSSK61.03964189
61ROCK21.03803184
62CDK51.03665159
63LMTK21.03436863
64BMPR21.02032746
65CDK11A1.01480435
66EIF2AK10.99920249
67PTK20.97818264
68CDK40.97481454
69FER0.95733171
70EPHA20.94891609
71CAMK2B0.93939078
72PRKCG0.92320100
73CDK70.91524111
74OXSR10.89342945
75CAMK2A0.87950217
76TYRO30.87165059
77ALK0.85908818
78CAMK1D0.85562833
79BRSK10.84945553
80PRKD30.84802819
81DAPK10.84289180
82MAP2K30.83978712
83PTK60.82971093
84TTN0.82157119
85RAF10.80394421
86LRRK20.79070574
87PDK40.77116314
88PDK30.77116314
89DDR20.76943607
90MAPK110.76577551
91FGFR30.76547042
92CASK0.75128171
93PAK30.74830983
94SCYL20.72317064
95CDK190.72265188
96RET0.71967412
97NEK20.71099417
98TAOK20.70281212
99CHEK20.68908121
100CSNK1E0.67529151
101TESK20.67116123
102AKT20.64361744
103PAK20.63678604
104MARK20.63320541
105PAK10.62033121
106MET0.61362125
107CHEK10.61280878
108PKN20.61111436
109PDPK10.61105629
110MAP3K10.60600899
111NTRK20.60291503
112VRK20.59444837
113CAMK2D0.59006759
114UHMK10.57324587
115AURKA0.56731569
116BMX0.56133726
117RPS6KB20.54679240
118AURKB0.54141258
119PRKG20.53954411
120EPHB10.53490880
121CAMKK10.51993454
122NEK60.51982718
123CAMK1G0.50969535
124MAP3K140.50735137
125WNK40.50387109
126BUB10.49997596
127ILK0.49692763
128TNK20.48990835
129MAP2K70.48304955
130CLK10.48243872
131ABL20.47905305
132SIK20.45994354
133STK110.45913039
134MAPKAPK50.43331872
135PLK30.43153075
136STK40.42710145
137CAMK2G0.42175976
138ADRBK10.41635129
139ERBB40.41406954
140PAK40.41040332
141MAP4K10.40979638
142PRKD20.40763625
143MELK0.40717188
144STK100.40377582
145CDK20.40315102
146SRPK10.39965961
147PKN10.39482619
148PBK0.39063597
149PDK10.38939276
150CDK10.38861222
151MARK10.38392103
152FGFR10.35550097
153SRC0.35275220
154MAPK120.35178105
155JAK10.35090138
156PRKCI0.34787985
157BRAF0.34248958
158MAP3K110.34127368
159* FYN0.33666189
160DMPK0.32913846
161CDC42BPA0.32054276
162PRKCQ0.31800217
163STK380.31348989
164INSR0.31278442

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28464880
2Parkinsons disease_Homo sapiens_hsa050123.38101145
3Alzheimers disease_Homo sapiens_hsa050103.29245060
4Nicotine addiction_Homo sapiens_hsa050333.06444536
5Long-term potentiation_Homo sapiens_hsa047202.80940144
6DNA replication_Homo sapiens_hsa030302.80244718
7Cardiac muscle contraction_Homo sapiens_hsa042602.69572673
8Synaptic vesicle cycle_Homo sapiens_hsa047212.68677934
9Huntingtons disease_Homo sapiens_hsa050162.49951400
10Vitamin B6 metabolism_Homo sapiens_hsa007502.41467038
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32212022
12Collecting duct acid secretion_Homo sapiens_hsa049662.32113903
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25067705
14Amphetamine addiction_Homo sapiens_hsa050312.20617352
15Salivary secretion_Homo sapiens_hsa049702.19075290
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13632503
17Chronic myeloid leukemia_Homo sapiens_hsa052201.99198387
18Glutamatergic synapse_Homo sapiens_hsa047241.94161290
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92579394
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.87043248
21Circadian entrainment_Homo sapiens_hsa047131.84174346
22Dopaminergic synapse_Homo sapiens_hsa047281.76038464
23GABAergic synapse_Homo sapiens_hsa047271.75346983
24Pentose phosphate pathway_Homo sapiens_hsa000301.74845028
25Thyroid cancer_Homo sapiens_hsa052161.71092114
26Ribosome_Homo sapiens_hsa030101.70607724
27Gastric acid secretion_Homo sapiens_hsa049711.70487853
28Renin secretion_Homo sapiens_hsa049241.67452357
29Spliceosome_Homo sapiens_hsa030401.67383683
30Long-term depression_Homo sapiens_hsa047301.65187830
31Galactose metabolism_Homo sapiens_hsa000521.62666907
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61343134
33Sulfur relay system_Homo sapiens_hsa041221.58430794
34Fructose and mannose metabolism_Homo sapiens_hsa000511.55483042
35One carbon pool by folate_Homo sapiens_hsa006701.52514258
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49408330
37Morphine addiction_Homo sapiens_hsa050321.48494805
38Other glycan degradation_Homo sapiens_hsa005111.48354015
39Non-small cell lung cancer_Homo sapiens_hsa052231.46694662
40Olfactory transduction_Homo sapiens_hsa047401.44721261
41Oxytocin signaling pathway_Homo sapiens_hsa049211.41135945
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40685420
43Cell cycle_Homo sapiens_hsa041101.39907070
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39868268
45Vibrio cholerae infection_Homo sapiens_hsa051101.39050843
46Serotonergic synapse_Homo sapiens_hsa047261.38823043
47Pancreatic cancer_Homo sapiens_hsa052121.32853643
48Taste transduction_Homo sapiens_hsa047421.30309722
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29870081
50Arginine biosynthesis_Homo sapiens_hsa002201.29345673
51Calcium signaling pathway_Homo sapiens_hsa040201.27393913
52GnRH signaling pathway_Homo sapiens_hsa049121.25284264
53Mismatch repair_Homo sapiens_hsa034301.20712094
54Gap junction_Homo sapiens_hsa045401.19303592
55Cholinergic synapse_Homo sapiens_hsa047251.17500049
56Notch signaling pathway_Homo sapiens_hsa043301.15094701
57Acute myeloid leukemia_Homo sapiens_hsa052211.15052901
58Small cell lung cancer_Homo sapiens_hsa052221.12985609
59Proteasome_Homo sapiens_hsa030501.10801512
60mRNA surveillance pathway_Homo sapiens_hsa030151.09748714
61Adherens junction_Homo sapiens_hsa045201.09662190
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08397845
63RNA transport_Homo sapiens_hsa030131.06449588
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05601591
65MicroRNAs in cancer_Homo sapiens_hsa052061.05019330
66Melanogenesis_Homo sapiens_hsa049161.04278851
67Focal adhesion_Homo sapiens_hsa045101.03510798
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03454650
69Estrogen signaling pathway_Homo sapiens_hsa049151.02603165
70Proteoglycans in cancer_Homo sapiens_hsa052051.02018585
71Insulin secretion_Homo sapiens_hsa049111.00017256
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99623261
73Prion diseases_Homo sapiens_hsa050200.98877798
74Base excision repair_Homo sapiens_hsa034100.97767567
75ECM-receptor interaction_Homo sapiens_hsa045120.97426860
76Glioma_Homo sapiens_hsa052140.96875598
77VEGF signaling pathway_Homo sapiens_hsa043700.95503796
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94501771
79Viral carcinogenesis_Homo sapiens_hsa052030.93996305
80Lysine degradation_Homo sapiens_hsa003100.93024556
81Insulin signaling pathway_Homo sapiens_hsa049100.91501293
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91399035
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91250822
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90802255
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88345447
86Endometrial cancer_Homo sapiens_hsa052130.87955428
87African trypanosomiasis_Homo sapiens_hsa051430.87784183
88B cell receptor signaling pathway_Homo sapiens_hsa046620.86648353
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86634042
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.86370449
91Oocyte meiosis_Homo sapiens_hsa041140.86302823
92Axon guidance_Homo sapiens_hsa043600.86036581
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81058721
94Nucleotide excision repair_Homo sapiens_hsa034200.80928909
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80790733
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80206648
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80054838
98Prostate cancer_Homo sapiens_hsa052150.77740270
99Apoptosis_Homo sapiens_hsa042100.77696611
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75831476
101Cocaine addiction_Homo sapiens_hsa050300.72681984
102HTLV-I infection_Homo sapiens_hsa051660.72197496
103Salmonella infection_Homo sapiens_hsa051320.71673428
104N-Glycan biosynthesis_Homo sapiens_hsa005100.71564927
105Complement and coagulation cascades_Homo sapiens_hsa046100.70922777
106Dilated cardiomyopathy_Homo sapiens_hsa054140.69104883
107Phagosome_Homo sapiens_hsa041450.68771654
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67289321
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65944927
110Thyroid hormone synthesis_Homo sapiens_hsa049180.65062278
111mTOR signaling pathway_Homo sapiens_hsa041500.64334738
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63338735
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.62502848
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61960294
115Phototransduction_Homo sapiens_hsa047440.61512896
116Nitrogen metabolism_Homo sapiens_hsa009100.61449901
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60126427
118Hepatitis B_Homo sapiens_hsa051610.60101845
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59771206
120Epstein-Barr virus infection_Homo sapiens_hsa051690.58045620
121Pyrimidine metabolism_Homo sapiens_hsa002400.57008664
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.55157625
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.55142057
124Pancreatic secretion_Homo sapiens_hsa049720.55090564
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54684953
126Glucagon signaling pathway_Homo sapiens_hsa049220.54451214
127cAMP signaling pathway_Homo sapiens_hsa040240.54321381
128Tight junction_Homo sapiens_hsa045300.54129009
129Alcoholism_Homo sapiens_hsa050340.54048457
130Fatty acid biosynthesis_Homo sapiens_hsa000610.53398537
131AMPK signaling pathway_Homo sapiens_hsa041520.52494861
132Tyrosine metabolism_Homo sapiens_hsa003500.52120478
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50695911
134Hepatitis C_Homo sapiens_hsa051600.49901917
135Colorectal cancer_Homo sapiens_hsa052100.48798441
136Bladder cancer_Homo sapiens_hsa052190.48713368
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48564569
138Inositol phosphate metabolism_Homo sapiens_hsa005620.47883423
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.47446811
140ErbB signaling pathway_Homo sapiens_hsa040120.47440733
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47085549
142Endocytosis_Homo sapiens_hsa041440.46932316
143Rheumatoid arthritis_Homo sapiens_hsa053230.46695030
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45754412
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45290431
146Choline metabolism in cancer_Homo sapiens_hsa052310.44794383
147Prolactin signaling pathway_Homo sapiens_hsa049170.44764698
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44106821
149Carbon metabolism_Homo sapiens_hsa012000.44004501
150Hippo signaling pathway_Homo sapiens_hsa043900.43056037
151Pyruvate metabolism_Homo sapiens_hsa006200.43006237
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42938985
153Shigellosis_Homo sapiens_hsa051310.42337000
154Amoebiasis_Homo sapiens_hsa051460.42300425
1552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42244967
156Pathways in cancer_Homo sapiens_hsa052000.42162259
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.41846813
158Dorso-ventral axis formation_Homo sapiens_hsa043200.41023982
159Rap1 signaling pathway_Homo sapiens_hsa040150.37624598
160MAPK signaling pathway_Homo sapiens_hsa040100.36896442
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36178900
162Biosynthesis of amino acids_Homo sapiens_hsa012300.33606443
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.33265194
164Type II diabetes mellitus_Homo sapiens_hsa049300.32936381
165HIF-1 signaling pathway_Homo sapiens_hsa040660.32874468
166Phenylalanine metabolism_Homo sapiens_hsa003600.32865688
167Ras signaling pathway_Homo sapiens_hsa040140.32344534
168Renal cell carcinoma_Homo sapiens_hsa052110.31098909
169Mineral absorption_Homo sapiens_hsa049780.26484859
170Systemic lupus erythematosus_Homo sapiens_hsa053220.25900498
171Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24317411

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