NMU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.55691952
2regulation of water loss via skin (GO:0033561)8.81053334
3gonadal mesoderm development (GO:0007506)8.44248917
4regulation of female gonad development (GO:2000194)7.30819723
5detection of temperature stimulus (GO:0016048)6.60320534
6piRNA metabolic process (GO:0034587)6.34194379
7multicellular organismal water homeostasis (GO:0050891)5.95434098
8desmosome organization (GO:0002934)5.46818559
9water homeostasis (GO:0030104)5.25709726
10skin morphogenesis (GO:0043589)5.14780522
11peptide cross-linking (GO:0018149)5.07341197
12DNA replication checkpoint (GO:0000076)4.91967324
13citrulline biosynthetic process (GO:0019240)4.87943111
14DNA topological change (GO:0006265)4.80643359
15ribosomal small subunit biogenesis (GO:0042274)4.76661934
16viral transcription (GO:0019083)4.76149506
17ribosomal small subunit assembly (GO:0000028)4.69759107
18translational termination (GO:0006415)4.66438306
19maturation of SSU-rRNA (GO:0030490)4.61884742
20DNA unwinding involved in DNA replication (GO:0006268)4.53411058
21keratinocyte differentiation (GO:0030216)4.52991171
22nuclear pore complex assembly (GO:0051292)4.48999172
23sphingosine metabolic process (GO:0006670)4.46339272
24mitotic sister chromatid segregation (GO:0000070)4.40420291
25chaperone-mediated protein transport (GO:0072321)4.40289142
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32157868
27regulation of translational fidelity (GO:0006450)4.30187410
28long-chain fatty acid biosynthetic process (GO:0042759)4.29254224
29histone H2A ubiquitination (GO:0033522)4.27746918
30histone H2A monoubiquitination (GO:0035518)4.27001726
31sister chromatid segregation (GO:0000819)4.26423907
32positive regulation of meiotic cell cycle (GO:0051446)4.18236033
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.16789484
34formation of translation preinitiation complex (GO:0001731)4.15860702
35nuclear pore organization (GO:0006999)4.13161909
36kinetochore organization (GO:0051383)4.12882446
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.07449299
38DNA strand elongation involved in DNA replication (GO:0006271)4.06173134
39DNA methylation involved in gamete generation (GO:0043046)4.06000085
40energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04482421
41ATP synthesis coupled proton transport (GO:0015986)4.04482421
42ribosomal large subunit biogenesis (GO:0042273)4.03651786
43male meiosis (GO:0007140)4.01922325
44cotranslational protein targeting to membrane (GO:0006613)4.01537978
45translational elongation (GO:0006414)3.98194091
46resolution of meiotic recombination intermediates (GO:0000712)3.95653793
47protein targeting to ER (GO:0045047)3.93900099
48DNA strand elongation (GO:0022616)3.92556655
49kinetochore assembly (GO:0051382)3.91834157
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91324838
51negative regulation of organelle assembly (GO:1902116)3.88865417
52regulation of cardioblast differentiation (GO:0051890)3.87852558
53regulation of histone phosphorylation (GO:0033127)3.86713083
54diol metabolic process (GO:0034311)3.85641760
55negative regulation of smooth muscle cell differentiation (GO:0051151)3.84519734
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81339457
57translational initiation (GO:0006413)3.80549406
58response to pheromone (GO:0019236)3.80330311
59cellular protein complex disassembly (GO:0043624)3.77469859
60protein kinase C signaling (GO:0070528)3.76337141
61CENP-A containing nucleosome assembly (GO:0034080)3.76312118
62protein localization to endoplasmic reticulum (GO:0070972)3.74843392
63oxidative phosphorylation (GO:0006119)3.74281412
64chromatin remodeling at centromere (GO:0031055)3.74155761
65intestinal epithelial cell development (GO:0060576)3.73314351
66ribonucleoprotein complex biogenesis (GO:0022613)3.73130307
67oocyte maturation (GO:0001556)3.71537427
68telomere maintenance via semi-conservative replication (GO:0032201)3.68689406
69female gamete generation (GO:0007292)3.67481308
70cranial nerve morphogenesis (GO:0021602)3.67323413
71negative regulation of meiotic cell cycle (GO:0051447)3.65811689
72interkinetic nuclear migration (GO:0022027)3.65715098
73regulation of meiosis (GO:0040020)3.65118318
74regulation of meiotic cell cycle (GO:0051445)3.64822879
75purine nucleobase biosynthetic process (GO:0009113)3.62902210
76viral life cycle (GO:0019058)3.62814219
77molting cycle (GO:0042303)3.62376238
78hair cycle (GO:0042633)3.62376238
79epidermal cell differentiation (GO:0009913)3.60145896
80DNA replication initiation (GO:0006270)3.59220246
81protein localization to kinetochore (GO:0034501)3.57950129
82synapsis (GO:0007129)3.57892294
83protein complex disassembly (GO:0043241)3.56901494
84mitotic metaphase plate congression (GO:0007080)3.56457406
85mitotic nuclear envelope disassembly (GO:0007077)3.55285759
86short-term memory (GO:0007614)3.55156509
87protein localization to chromosome, centromeric region (GO:0071459)3.54604302
88attachment of spindle microtubules to kinetochore (GO:0008608)3.50633156
89protoporphyrinogen IX metabolic process (GO:0046501)3.49366483
90proteasome assembly (GO:0043248)3.47076705
91homocysteine metabolic process (GO:0050667)3.44889872
92macromolecular complex disassembly (GO:0032984)3.44881813
93microtubule depolymerization (GO:0007019)3.43704853
94regulation of keratinocyte differentiation (GO:0045616)3.40847716
95sphingoid metabolic process (GO:0046519)3.40844045
96DNA replication-independent nucleosome organization (GO:0034724)3.37822765
97DNA replication-independent nucleosome assembly (GO:0006336)3.37822765
98pore complex assembly (GO:0046931)3.37068652
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36711252
100tRNA aminoacylation for protein translation (GO:0006418)3.36308513
101ribosome biogenesis (GO:0042254)3.33765923
102oocyte development (GO:0048599)3.31731638
103nucleobase biosynthetic process (GO:0046112)3.31037952
104bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30103058
105pyrimidine nucleotide catabolic process (GO:0006244)3.27991681
106amino acid activation (GO:0043038)3.27718440
107tRNA aminoacylation (GO:0043039)3.27718440
108negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27703264
109mitotic chromosome condensation (GO:0007076)3.27449599
110regulation of mitotic spindle organization (GO:0060236)3.26741463
111translation (GO:0006412)3.24402354
112nuclear envelope disassembly (GO:0051081)3.24320545
113membrane disassembly (GO:0030397)3.24320545
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23306637
115mitotic recombination (GO:0006312)3.21446380
116chromosome segregation (GO:0007059)3.21316265
117IMP biosynthetic process (GO:0006188)3.19446985
118metaphase plate congression (GO:0051310)3.18269299
119meiotic chromosome segregation (GO:0045132)3.17948052
120protoporphyrinogen IX biosynthetic process (GO:0006782)3.17889853
121telomere maintenance via recombination (GO:0000722)3.15631578
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14964266
123detection of temperature stimulus involved in sensory perception (GO:0050961)3.13920743
124detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.13920743
125respiratory electron transport chain (GO:0022904)3.13653314
126neuronal action potential propagation (GO:0019227)3.12505221
127histone exchange (GO:0043486)3.12484025
128cellular component biogenesis (GO:0044085)3.11805263
129negative regulation of chromosome segregation (GO:0051985)3.10895696
130negative regulation of execution phase of apoptosis (GO:1900118)3.10237091
131pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10120906
132intermediate filament cytoskeleton organization (GO:0045104)3.07999137
133intermediate filament organization (GO:0045109)3.07730452
134negative regulation of mitotic sister chromatid separation (GO:2000816)3.07663752
135negative regulation of sister chromatid segregation (GO:0033046)3.07663752
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07663752
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07663752
138negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07663752
139proline biosynthetic process (GO:0006561)3.07660212
140cytoplasmic microtubule organization (GO:0031122)3.07093940
141positive regulation of male gonad development (GO:2000020)3.05662989
142glycerophospholipid catabolic process (GO:0046475)3.05597649
143electron transport chain (GO:0022900)3.04617380
144mitotic spindle assembly checkpoint (GO:0007094)3.04092400
145pseudouridine synthesis (GO:0001522)3.03385508
146mitotic spindle checkpoint (GO:0071174)3.02389871
147regulation of meiosis I (GO:0060631)3.01980818
148sulfate transmembrane transport (GO:1902358)3.00964156
149gas transport (GO:0015669)2.99962583
150intermediate filament-based process (GO:0045103)2.99778921
151regulation of mitochondrial translation (GO:0070129)2.99275020
152spindle assembly checkpoint (GO:0071173)2.98888365
153nuclear-transcribed mRNA catabolic process (GO:0000956)2.98407841
154DNA damage induced protein phosphorylation (GO:0006975)2.98400060
155regulation of chromosome segregation (GO:0051983)2.95112430
156spindle checkpoint (GO:0031577)2.94852207
157ovulation cycle (GO:0042698)2.93334156
158folic acid-containing compound biosynthetic process (GO:0009396)2.91938296
159sulfate transport (GO:0008272)2.91462904
160rRNA processing (GO:0006364)2.90935753
161centriole replication (GO:0007099)2.90008805
162positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.85183168
163regulation of exit from mitosis (GO:0007096)2.85043545
164epidermis development (GO:0008544)2.83693627
165positive regulation of meiosis (GO:0045836)2.81897606
166regulation of inositol phosphate biosynthetic process (GO:0010919)2.81604559
167aggressive behavior (GO:0002118)2.80856249
168negative regulation of meiosis (GO:0045835)2.78739208
169positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.76772463
170meiotic cell cycle (GO:0051321)2.75641729
171regulation of neuron projection regeneration (GO:0070570)2.73666260
172regulation of axon regeneration (GO:0048679)2.73666260
173negative regulation of reproductive process (GO:2000242)2.69051008
174glycine transport (GO:0015816)2.67932061
175regulation of secondary heart field cardioblast proliferation (GO:0003266)2.66373589
176regulation of cardioblast proliferation (GO:0003264)2.66373589
177retinal ganglion cell axon guidance (GO:0031290)2.65902372
178regulation of DNA methylation (GO:0044030)2.65468791
179citrulline metabolic process (GO:0000052)2.64806174
180cell migration in hindbrain (GO:0021535)2.59172752
181eye photoreceptor cell differentiation (GO:0001754)2.58864866
182photoreceptor cell differentiation (GO:0046530)2.58864866
183fatty acid elongation (GO:0030497)2.56450863
184ventricular cardiac muscle cell action potential (GO:0086005)2.56257279
185synaptonemal complex organization (GO:0070193)2.51988923
186protein homotrimerization (GO:0070207)2.51418128
187negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.50024073
188negative regulation of homotypic cell-cell adhesion (GO:0034111)2.47747201
189regulation of male gonad development (GO:2000018)2.47670634
190peptidyl-arginine modification (GO:0018195)2.45726549
191positive regulation of sodium ion transmembrane transport (GO:1902307)2.42321174
192notochord development (GO:0030903)2.41293879
193microtubule anchoring (GO:0034453)2.39563744
194ectoderm development (GO:0007398)2.38922178
195negative regulation of keratinocyte proliferation (GO:0010839)2.37269353
196cell aggregation (GO:0098743)2.36100344
197keratinization (GO:0031424)12.3386556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.82956516
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.21055908
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.02127326
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92902644
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67458614
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64624641
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.64138612
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27705921
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23007692
10EZH2_22144423_ChIP-Seq_EOC_Human3.10939140
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07231250
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01103593
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96726120
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.91374557
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.89316576
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.88383956
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83629113
18XRN2_22483619_ChIP-Seq_HELA_Human2.76213109
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68024359
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54162528
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44095757
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38115103
23TTF2_22483619_ChIP-Seq_HELA_Human2.26998625
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25304208
25DCP1A_22483619_ChIP-Seq_HELA_Human2.23472946
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20145408
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17699553
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15241895
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12523124
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08053680
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.07726456
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06360067
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05182475
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03186174
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03015918
36EZH2_27304074_Chip-Seq_ESCs_Mouse2.01229336
37GABP_19822575_ChIP-Seq_HepG2_Human1.96661482
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96061201
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.95807957
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.95672945
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.94626701
42FOXP3_21729870_ChIP-Seq_TREG_Human1.92465903
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90373034
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89002850
45ELK1_19687146_ChIP-ChIP_HELA_Human1.84793907
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84510888
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83718713
48VDR_23849224_ChIP-Seq_CD4+_Human1.83508921
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.82453841
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80775953
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80775953
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79307121
53AR_21909140_ChIP-Seq_LNCAP_Human1.79000426
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75105359
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74191459
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72420436
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72410048
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69746729
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.69186052
60KDM5A_27292631_Chip-Seq_BREAST_Human1.68963935
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67703165
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66640596
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66036936
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65908058
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.65543197
66NCOR1_26117541_ChIP-Seq_K562_Human1.65103011
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.64758221
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.62397471
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60765818
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.59967183
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59242077
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57720426
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56884216
74RNF2_27304074_Chip-Seq_NSC_Mouse1.56779379
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56595040
76GBX2_23144817_ChIP-Seq_PC3_Human1.56572654
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55709464
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.54840029
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54089711
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53390402
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53266198
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52704880
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48809269
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.46209649
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43986957
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.43322041
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41103596
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38317702
89ZNF263_19887448_ChIP-Seq_K562_Human1.37157637
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35135543
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31780220
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.31434028
93GATA3_21867929_ChIP-Seq_TH1_Mouse1.31295701
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30660945
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30548045
96RUNX1_26923725_Chip-Seq_HPCs_Mouse1.30227213
97* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28615666
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25423897
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25280434
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25252781
101GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23459165
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.23145829
103MYC_18940864_ChIP-ChIP_HL60_Human1.22466716
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22358462
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21987151
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.21045327
107TP63_23658742_ChIP-Seq_EP156T_Human1.20527866
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19417381
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.19193148
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18371358
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.17689357
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17331164
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17275331
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17145433
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17032965
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16917320
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16214931
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15866036
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15640222
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15150978
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14803690
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14329241
123RING1B_27294783_Chip-Seq_ESCs_Mouse1.13826507
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11873201
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10712476
126SMAD4_21799915_ChIP-Seq_A2780_Human1.10363751
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.10040774
128CIITA_25753668_ChIP-Seq_RAJI_Human1.09511381
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09221287
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09151108
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08954263
132ESR2_21235772_ChIP-Seq_MCF-7_Human1.08715147
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08463435
134KDM2B_26808549_Chip-Seq_REH_Human1.08439530
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07781444
136CJUN_26792858_Chip-Seq_BT549_Human1.07415713
137P300_19829295_ChIP-Seq_ESCs_Human1.05409824
138AR_25329375_ChIP-Seq_VCAP_Human1.05389861
139OCT1_27270436_Chip-Seq_PROSTATE_Human1.04988475
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04483341
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04461325
142STAT3_23295773_ChIP-Seq_U87_Human1.04276688
143SOX2_21211035_ChIP-Seq_LN229_Gbm1.03767587
144ESR1_20079471_ChIP-ChIP_T-47D_Human1.03676025
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03482915
146ERG_20517297_ChIP-Seq_VCAP_Human1.03095423
147GF1B_26923725_Chip-Seq_HPCs_Mouse1.02935458
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.02864583
149STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02426294
150CTCF_27219007_Chip-Seq_Bcells_Human1.02158788
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02102425
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01961954
153GATA6_21074721_ChIP-Seq_CACO-2_Human1.01545022
154FOXO3_23340844_ChIP-Seq_DLD1_Human1.01492066
155FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00332555
156SMAD3_21741376_ChIP-Seq_EPCs_Human1.00274575
157GATA1_19941826_ChIP-Seq_K562_Human1.00143251
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98673948
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97885433
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96420510
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95970980
162CTCF_18555785_Chip-Seq_ESCs_Mouse0.95884033
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95791405
164HTT_18923047_ChIP-ChIP_STHdh_Human0.94949468
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94438637
166PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93556310
167NANOG_20526341_ChIP-Seq_ESCs_Human0.92889989
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.92682599
169PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92299561
170VDR_22108803_ChIP-Seq_LS180_Human0.92023477
171TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91933524
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91807152
173EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91111286
174P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90918903
175SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89861382
176ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89503258
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89004690
178AHR_22903824_ChIP-Seq_MCF-7_Human0.88972903
179CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88942719
180CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88936201
181IGF1R_20145208_ChIP-Seq_DFB_Human0.88928295
182CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87920931
183FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86120958
184SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85742123
185SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83233396
186FOXP1_21924763_ChIP-Seq_HESCs_Human0.81332827
187DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80064445
188HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77522009
189CHD1_26751641_Chip-Seq_LNCaP_Human0.77036735
190TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76779659
191* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76652607
192TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72163568
193MYC_22102868_ChIP-Seq_BL_Human0.70316192
194SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69982266
195ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69569249
196TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.67160644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.17188076
2MP0005275_abnormal_skin_tensile4.74396226
3MP0004147_increased_porphyrin_level4.02126160
4MP0004957_abnormal_blastocyst_morpholog3.91343923
5MP0010094_abnormal_chromosome_stability3.89676953
6MP0008058_abnormal_DNA_repair3.76266078
7MP0002736_abnormal_nociception_after3.50227522
8MP0005501_abnormal_skin_physiology3.42288664
9MP0005451_abnormal_body_composition3.40260870
10MP0006292_abnormal_olfactory_placode3.16123708
11MP0001188_hyperpigmentation3.01595680
12MP0000579_abnormal_nail_morphology3.00542311
13MP0008995_early_reproductive_senescence2.96504705
14MP0003077_abnormal_cell_cycle2.88005733
15MP0003718_maternal_effect2.87412935
16MP0002249_abnormal_larynx_morphology2.81681781
17MP0010234_abnormal_vibrissa_follicle2.78013598
18MP0001968_abnormal_touch/_nociception2.66356336
19MP0003646_muscle_fatigue2.63650624
20MP0009697_abnormal_copulation2.58051596
21MP0004270_analgesia2.57021316
22MP0004742_abnormal_vestibular_system2.56121844
23MP0000647_abnormal_sebaceous_gland2.40960849
24MP0008057_abnormal_DNA_replication2.37938002
25MP0000678_abnormal_parathyroid_gland2.29185266
26MP0003786_premature_aging2.27013168
27MP0002733_abnormal_thermal_nociception2.26829823
28MP0010771_integument_phenotype2.26105622
29MP0009379_abnormal_foot_pigmentation2.21377829
30MP0008007_abnormal_cellular_replicative2.16881900
31MP0003315_abnormal_perineum_morphology2.10421930
32MP0000372_irregular_coat_pigmentation2.08260804
33MP0004859_abnormal_synaptic_plasticity1.94658207
34MP0008877_abnormal_DNA_methylation1.94197483
35MP0002234_abnormal_pharynx_morphology1.90396922
36MP0003705_abnormal_hypodermis_morpholog1.86216497
37MP0003186_abnormal_redox_activity1.83084778
38MP0001346_abnormal_lacrimal_gland1.76961926
39MP0003656_abnormal_erythrocyte_physiolo1.74010175
40MP0001970_abnormal_pain_threshold1.73313326
41MP0001440_abnormal_grooming_behavior1.71984067
42MP0000427_abnormal_hair_cycle1.71542420
43MP0006036_abnormal_mitochondrial_physio1.69945848
44MP0002132_abnormal_respiratory_system1.69819038
45MP0002734_abnormal_mechanical_nocicepti1.66448116
46MP0001697_abnormal_embryo_size1.65907197
47MP0006035_abnormal_mitochondrial_morpho1.65480061
48MP0005083_abnormal_biliary_tract1.63247607
49MP0003123_paternal_imprinting1.63067654
50MP0000350_abnormal_cell_proliferation1.61350304
51MP0001730_embryonic_growth_arrest1.61170955
52MP0002938_white_spotting1.58393678
53MP0001216_abnormal_epidermal_layer1.56425602
54MP0002735_abnormal_chemical_nociception1.55526165
55MP0002060_abnormal_skin_morphology1.50523639
56MP0004947_skin_inflammation1.48693071
57MP0003453_abnormal_keratinocyte_physiol1.47362084
58MP0006072_abnormal_retinal_apoptosis1.47115332
59MP0005380_embryogenesis_phenotype1.46671592
60MP0001672_abnormal_embryogenesis/_devel1.46671592
61MP0004145_abnormal_muscle_electrophysio1.44895573
62MP0009384_cardiac_valve_regurgitation1.43434927
63MP0002282_abnormal_trachea_morphology1.40330100
64MP0010030_abnormal_orbit_morphology1.38620874
65MP0003880_abnormal_central_pattern1.37245703
66MP0002080_prenatal_lethality1.36073699
67MP0000313_abnormal_cell_death1.32853219
68MP0000762_abnormal_tongue_morphology1.32532842
69MP0003984_embryonic_growth_retardation1.30983931
70MP0000377_abnormal_hair_follicle1.29741594
71MP0005187_abnormal_penis_morphology1.28887496
72MP0010678_abnormal_skin_adnexa1.28123147
73MP0002088_abnormal_embryonic_growth/wei1.26268966
74MP0002085_abnormal_embryonic_tissue1.24431985
75MP0005646_abnormal_pituitary_gland1.23558812
76MP0001485_abnormal_pinna_reflex1.23429028
77MP0001293_anophthalmia1.22981273
78MP0002177_abnormal_outer_ear1.22339189
79MP0009250_abnormal_appendicular_skeleto1.22030737
80MP0010307_abnormal_tumor_latency1.19800942
81MP0002084_abnormal_developmental_patter1.18624647
82MP0003806_abnormal_nucleotide_metabolis1.17720199
83MP0003699_abnormal_female_reproductive1.16394588
84MP0008789_abnormal_olfactory_epithelium1.15136393
85MP0005171_absent_coat_pigmentation1.12928359
86MP0002098_abnormal_vibrissa_morphology1.11817946
87MP0002095_abnormal_skin_pigmentation1.11730371
88MP0003879_abnormal_hair_cell1.11690114
89MP0004381_abnormal_hair_follicle1.11411875
90MP0003136_yellow_coat_color1.09352129
91MP0001243_abnormal_dermal_layer1.06684561
92MP0001545_abnormal_hematopoietic_system1.06129752
93MP0005397_hematopoietic_system_phenotyp1.06129752
94MP0003937_abnormal_limbs/digits/tail_de1.05030247
95MP0003938_abnormal_ear_development1.04880182
96MP0003950_abnormal_plasma_membrane1.04755708
97MP0000631_abnormal_neuroendocrine_gland1.04519451
98MP0003567_abnormal_fetal_cardiomyocyte1.04228772
99MP0000049_abnormal_middle_ear1.03759405
100MP0001727_abnormal_embryo_implantation1.03623058
101MP0003755_abnormal_palate_morphology1.03273427
102MP0005395_other_phenotype1.03207112
103MP0006138_congestive_heart_failure1.02772357
104MP0001764_abnormal_homeostasis1.02081035
105MP0000358_abnormal_cell_content/1.01340695
106MP0000751_myopathy1.00560396
107MP0002184_abnormal_innervation1.00443108
108MP0003941_abnormal_skin_development1.00298774
109MP0003385_abnormal_body_wall0.99747934
110MP0000566_synostosis0.99506083
111MP0003787_abnormal_imprinting0.99355651
112MP0003566_abnormal_cell_adhesion0.98681721
113MP0008932_abnormal_embryonic_tissue0.97818295
114MP0005499_abnormal_olfactory_system0.96879621
115MP0005394_taste/olfaction_phenotype0.96879621
116MP0000681_abnormal_thyroid_gland0.96686771
117MP0005360_urolithiasis0.96207852
118MP0001119_abnormal_female_reproductive0.95664606
119MP0009931_abnormal_skin_appearance0.94459378
120MP0001661_extended_life_span0.93980762
121MP0003942_abnormal_urinary_system0.93128519
122MP0002210_abnormal_sex_determination0.92929851
123MP0000653_abnormal_sex_gland0.92496378
124MP0003698_abnormal_male_reproductive0.92443510
125MP0005636_abnormal_mineral_homeostasis0.90995150
126MP0001299_abnormal_eye_distance/0.89542004
127MP0001851_eye_inflammation0.89513363
128MP0002086_abnormal_extraembryonic_tissu0.88927784
129MP0003635_abnormal_synaptic_transmissio0.88813286
130MP0001529_abnormal_vocalization0.88332466
131MP0001929_abnormal_gametogenesis0.87008417
132MP0002111_abnormal_tail_morphology0.85454764
133MP0000383_abnormal_hair_follicle0.85113071
134MP0010386_abnormal_urinary_bladder0.84425933
135MP0001286_abnormal_eye_development0.83615413
136MP0002233_abnormal_nose_morphology0.83104854
137MP0005408_hypopigmentation0.81952439
138MP0004233_abnormal_muscle_weight0.81932769
139MP0004885_abnormal_endolymph0.81262465
140MP0003890_abnormal_embryonic-extraembry0.80270794
141MP0004197_abnormal_fetal_growth/weight/0.77692954
142MP0006276_abnormal_autonomic_nervous0.76678750
143MP0002067_abnormal_sensory_capabilities0.75451837
144MP0002161_abnormal_fertility/fecundity0.75375476
145MP0009672_abnormal_birth_weight0.74884217
146MP0000733_abnormal_muscle_development0.73125412
147MP0002019_abnormal_tumor_incidence0.72269844
148MP0003091_abnormal_cell_migration0.71929352
149MP0003121_genomic_imprinting0.71176412
150MP0004185_abnormal_adipocyte_glucose0.71090197
151MP0003693_abnormal_embryo_hatching0.70885199
152MP0001340_abnormal_eyelid_morphology0.70456657
153MP0005257_abnormal_intraocular_pressure0.69429476
154MP0003861_abnormal_nervous_system0.69105548
155MP0003221_abnormal_cardiomyocyte_apopto0.68685950
156MP0008775_abnormal_heart_ventricle0.67444619
157MP0001881_abnormal_mammary_gland0.66607543
158* MP0001502_abnormal_circadian_rhythm0.66016759
159MP0000955_abnormal_spinal_cord0.65558938
160MP0002697_abnormal_eye_size0.65304235
161MP0003959_abnormal_lean_body0.62967497
162MP0008770_decreased_survivor_rate0.62826504
163MP0000428_abnormal_craniofacial_morphol0.61493880
164MP0003935_abnormal_craniofacial_develop0.61276800
165MP0008004_abnormal_stomach_pH0.60402584
166MP0002163_abnormal_gland_morphology0.60017380
167MP0004811_abnormal_neuron_physiology0.59062552
168MP0001963_abnormal_hearing_physiology0.58816180
169MP0003111_abnormal_nucleus_morphology0.57759042
170MP0002064_seizures0.57363157
171MP0002272_abnormal_nervous_system0.57063248
172MP0001145_abnormal_male_reproductive0.57044351
173MP0001486_abnormal_startle_reflex0.54954887

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.24755492
2Myokymia (HP:0002411)6.35029466
3Erythroderma (HP:0001019)6.22087582
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.02490598
5Parakeratosis (HP:0001036)5.68472980
6Conjunctival hamartoma (HP:0100780)5.61098781
7Sensory axonal neuropathy (HP:0003390)4.88570921
8Congenital ichthyosiform erythroderma (HP:0007431)4.82565720
9Hypotrichosis (HP:0001006)4.67054843
10Cholecystitis (HP:0001082)4.53685991
11Abnormal gallbladder physiology (HP:0012438)4.53685991
12Reticulocytopenia (HP:0001896)4.43843756
13Truncus arteriosus (HP:0001660)4.43276033
14Abnormality of reticulocytes (HP:0004312)4.41386910
15Reticulocytosis (HP:0001923)4.40223140
16Hyperthyroidism (HP:0000836)4.30137933
17Erythema (HP:0010783)4.25755565
18Abnormality of cells of the erythroid lineage (HP:0012130)3.84964565
19Pallor (HP:0000980)3.78424644
20Birth length less than 3rd percentile (HP:0003561)3.76121563
21Acute necrotizing encephalopathy (HP:0006965)3.73194327
22Acute encephalopathy (HP:0006846)3.69024797
23Abnormal mitochondria in muscle tissue (HP:0008316)3.67528063
24Abnormal number of erythroid precursors (HP:0012131)3.62928120
25Gangrene (HP:0100758)3.62856951
26Abnormality of the lower motor neuron (HP:0002366)3.55683277
27Metaphyseal cupping (HP:0003021)3.52468394
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.50367667
29Onycholysis (HP:0001806)3.48608296
30Hamartoma of the eye (HP:0010568)3.40889670
31Metaphyseal dysplasia (HP:0100255)3.40075246
32Male infertility (HP:0003251)3.39342161
33Congenital sensorineural hearing impairment (HP:0008527)3.36949663
34Palmoplantar hyperkeratosis (HP:0000972)3.26871861
35Macrocytic anemia (HP:0001972)3.25345064
36Right ventricular cardiomyopathy (HP:0011663)3.22023791
37Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.19293068
38Pili torti (HP:0003777)3.17214789
39Palmar hyperkeratosis (HP:0010765)3.17021755
40Abnormality of glycolysis (HP:0004366)3.13810820
41Increased serum pyruvate (HP:0003542)3.08432603
42Breast hypoplasia (HP:0003187)3.07961808
43Myotonia (HP:0002486)2.97404759
44Abnormality of homocysteine metabolism (HP:0010919)2.96283655
45Homocystinuria (HP:0002156)2.96283655
46Progressive macrocephaly (HP:0004481)2.92398339
47Ectropion (HP:0000656)2.86691685
48Abnormal hemoglobin (HP:0011902)2.83959242
49Hypertensive crisis (HP:0100735)2.82466815
50Seborrheic dermatitis (HP:0001051)2.82452965
51Woolly hair (HP:0002224)2.81161848
52Plantar hyperkeratosis (HP:0007556)2.79948828
53Hypoparathyroidism (HP:0000829)2.73964261
54Polycythemia (HP:0001901)2.69533550
55Hypergammaglobulinemia (HP:0010702)2.65419920
56Ulnar claw (HP:0001178)2.65200638
57Increased CSF lactate (HP:0002490)2.64847151
58Mitochondrial inheritance (HP:0001427)2.64308756
59Hip contracture (HP:0003273)2.59612484
60Short middle phalanx of the 5th finger (HP:0004220)2.58927277
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58870795
62Akinesia (HP:0002304)2.54394958
63Eczematoid dermatitis (HP:0000976)2.50825153
64Abnormality of the tricuspid valve (HP:0001702)2.50345863
65Increased hepatocellular lipid droplets (HP:0006565)2.49396012
66Poikilocytosis (HP:0004447)2.49049453
67Aplasia/Hypoplasia of the earlobes (HP:0009906)2.47064256
68Bowel incontinence (HP:0002607)2.45786785
69Cerebral edema (HP:0002181)2.42321902
70Limited hip movement (HP:0008800)2.40161585
71Abnormal large intestine physiology (HP:0012700)2.39433847
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.38250601
73Cholelithiasis (HP:0001081)2.38229176
74Abnormality of secondary sexual hair (HP:0009888)2.37645020
75Abnormality of the axillary hair (HP:0100134)2.37645020
76Lipid accumulation in hepatocytes (HP:0006561)2.32367665
77Vascular calcification (HP:0004934)2.31877015
78Abnormality of the preputium (HP:0100587)2.29726687
79Ventricular fibrillation (HP:0001663)2.29287382
80Corneal erosion (HP:0200020)2.27984410
81Atonic seizures (HP:0010819)2.27666930
82Abnormality of the labia minora (HP:0012880)2.26765258
83Ileus (HP:0002595)2.25630023
84Small intestinal stenosis (HP:0012848)2.24918581
85Duodenal stenosis (HP:0100867)2.24918581
86Obstructive sleep apnea (HP:0002870)2.23608901
87Double outlet right ventricle (HP:0001719)2.21514714
88Congenital malformation of the right heart (HP:0011723)2.21514714
89Duplicated collecting system (HP:0000081)2.20310398
90Increased serum lactate (HP:0002151)2.19753787
91Supranuclear gaze palsy (HP:0000605)2.14671670
92Myelodysplasia (HP:0002863)2.14521472
93Ankyloglossia (HP:0010296)2.13215385
94Abnormal gallbladder morphology (HP:0012437)2.12483751
95Abnormality of chromosome stability (HP:0003220)2.11844838
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11593871
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11099761
98Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11099761
99Hypoplastic ischia (HP:0003175)2.10600982
100Abnormality of nail color (HP:0100643)2.09205604
101Hepatocellular necrosis (HP:0001404)2.08995012
102Hypoplastic pelvis (HP:0008839)2.08691946
103Hammertoe (HP:0001765)2.08399683
104Lactic acidosis (HP:0003128)2.07599081
105Infertility (HP:0000789)2.07208548
106Horseshoe kidney (HP:0000085)2.06377707
107Increased intramyocellular lipid droplets (HP:0012240)2.06077672
108Meckel diverticulum (HP:0002245)2.05455297
109Cardiovascular calcification (HP:0011915)2.05260241
110Abnormally folded helix (HP:0008544)2.05115690
111Acanthocytosis (HP:0001927)2.03548617
112Hyperbilirubinemia (HP:0002904)2.03395949
113Renal Fanconi syndrome (HP:0001994)1.99873756
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.99743586
115Morphological abnormality of the inner ear (HP:0011390)1.99387532
116Increased nuchal translucency (HP:0010880)1.99148206
117Difficulty climbing stairs (HP:0003551)1.98317869
118Respiratory difficulties (HP:0002880)1.98165870
119Abnormality of the renal collecting system (HP:0004742)1.97570540
120Flat capital femoral epiphysis (HP:0003370)1.97456339
121Ankle clonus (HP:0011448)1.95608619
122Fetal akinesia sequence (HP:0001989)1.94701844
123Upper limb muscle weakness (HP:0003484)1.93799937
124Mild short stature (HP:0003502)1.93566179
125Abnormality of the ileum (HP:0001549)1.93512386
126Cortical dysplasia (HP:0002539)1.93404947
127Hepatic necrosis (HP:0002605)1.92871510
128Abnormality of the epiphysis of the femoral head (HP:0010574)1.92589827
129Degeneration of anterior horn cells (HP:0002398)1.91282170
130Abnormality of the anterior horn cell (HP:0006802)1.91282170
131Atelectasis (HP:0100750)1.91254342
132Abnormal lung lobation (HP:0002101)1.90194500
133Lack of skin elasticity (HP:0100679)1.89357352
134Redundant skin (HP:0001582)1.89173744
135Sleep apnea (HP:0010535)1.89095341
136Slow saccadic eye movements (HP:0000514)1.88867887
137Oral leukoplakia (HP:0002745)1.88675520
138Enlarged epiphyses (HP:0010580)1.88450844
139Exercise intolerance (HP:0003546)1.87853253
140Foot dorsiflexor weakness (HP:0009027)1.87822307
141Aplasia/Hypoplasia of the thymus (HP:0010515)1.87346076
142Absent radius (HP:0003974)1.86971185
143Premature ovarian failure (HP:0008209)1.86765882
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.85749418
145Aplasia/Hypoplasia of the breasts (HP:0010311)1.84832475
146Irregular epiphyses (HP:0010582)1.83987228
147Achilles tendon contracture (HP:0001771)1.83961687
148Nail dystrophy (HP:0008404)1.82950836
149Spastic gait (HP:0002064)1.82587345
150Sparse eyelashes (HP:0000653)1.82234211
151Overfolded helix (HP:0000396)1.81647032
152Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.81112830
153Abnormality of femoral epiphyses (HP:0006499)1.81112830
154Abnormality of the gallbladder (HP:0005264)1.81104434
155Chromsome breakage (HP:0040012)1.80630393
156Abnormality of the ischium (HP:0003174)1.80261564
157Cheekbone underdevelopment (HP:0010669)1.79804668
158Duplication of thumb phalanx (HP:0009942)1.79253330
159Abnormality of the duodenum (HP:0002246)1.78422263
160Hyperphosphatemia (HP:0002905)1.78350148
161Abnormality of DNA repair (HP:0003254)1.77619473
162Onion bulb formation (HP:0003383)1.77182505
163Aplasia involving forearm bones (HP:0009822)1.76909585
164Absent forearm bone (HP:0003953)1.76909585
165Abnormality of cochlea (HP:0000375)1.75943704
166Cerebral hypomyelination (HP:0006808)1.74098187
167Waddling gait (HP:0002515)1.73844648
168Absent thumb (HP:0009777)1.73072945
169Steppage gait (HP:0003376)1.73072436
170Cupped ribs (HP:0000887)1.72379297
171Abnormality of the femoral head (HP:0003368)1.72007094
172Triphalangeal thumb (HP:0001199)1.71794597
173Abnormal blistering of the skin (HP:0008066)1.71649412
17411 pairs of ribs (HP:0000878)1.70758540
175Increased muscle lipid content (HP:0009058)1.70394069
176Hypohidrosis (HP:0000966)1.70091555
177Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70057283
178Microvesicular hepatic steatosis (HP:0001414)1.69316157
179Sloping forehead (HP:0000340)1.68344424
180Genu varum (HP:0002970)1.68103846
181Lip pit (HP:0100267)1.67855699
182Dysmetria (HP:0001310)1.67793369
183Pruritus (HP:0000989)1.67471839
184Abnormality of the vertebral endplates (HP:0005106)1.66850171
185Spinal muscular atrophy (HP:0007269)1.66145576
186Abnormality of the Achilles tendon (HP:0005109)1.65960336
187Oligodontia (HP:0000677)1.64597921
188Abnormality of the carotid arteries (HP:0005344)1.62855577
189Progressive muscle weakness (HP:0003323)1.62641964
190Leukodystrophy (HP:0002415)1.62221209
191Respiratory failure (HP:0002878)1.60843576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.77545478
2ARAF4.09475434
3MAP3K93.52927706
4KSR23.51155184
5EIF2AK13.35856109
6NEK13.34668701
7MAP3K62.87919830
8SRPK12.81238941
9CLK12.77331871
10ERBB42.61734671
11WEE12.61373210
12NME22.36669907
13PBK2.35303881
14CDK82.35031621
15FER2.32110837
16BLK2.14684179
17GRK52.10196447
18BRAF2.07268489
19BRSK22.06407476
20LATS21.99788906
21STK391.99643112
22EPHB11.98180931
23CCNB11.97556198
24NEK21.97246715
25TSSK61.96350992
26NTRK31.91388837
27PLK31.83733321
28PDK21.79577940
29MAP3K121.79279593
30MOS1.78149597
31TAOK11.78077433
32MAPKAPK31.77895185
33MAP3K21.73190051
34BRSK11.69384535
35EPHA41.59212288
36LATS11.58115230
37RAF11.54995907
38MAP3K11.54144992
39BMPR21.50366125
40EEF2K1.47487639
41MUSK1.45863707
42ZAK1.44576354
43ATR1.43651383
44CHEK21.41156746
45STK161.35199648
46CDK91.32348920
47MKNK11.29423349
48TTK1.28785937
49PAK61.27428500
50AURKB1.26784863
51TAOK31.25973919
52MAP2K41.25866690
53PLK41.24935228
54MAP3K131.23153782
55OXSR11.20681181
56STK41.18031655
57CHEK11.14883675
58RPS6KA41.13268377
59EPHB21.12583103
60EPHA31.11825912
61BMX1.07136716
62NTRK21.02744926
63DYRK31.01528697
64DYRK21.01223531
65PHKG21.00021911
66PHKG11.00021911
67BUB10.98317743
68CDC70.98299190
69PASK0.97318458
70STK30.97276924
71BCKDK0.95327077
72MARK20.94445693
73MAPK130.93657199
74PRKD30.93548553
75MELK0.88786843
76ATM0.88181173
77CASK0.86463293
78RPS6KB20.86460514
79NUAK10.85944759
80MST40.85917732
81STK100.85715095
82PAK30.83254904
83CDK10.82861753
84CSNK2A20.79834021
85RET0.77411477
86PAK10.75540771
87CDK20.75411081
88PIM20.75109475
89MKNK20.72895245
90NTRK10.72473165
91MAP2K10.71646448
92WNK10.71011330
93CDK70.70688943
94LRRK20.68372453
95KSR10.67909388
96CSNK2A10.67283341
97CSNK1E0.65642513
98VRK20.64079195
99ABL20.64068978
100STK380.62933882
101CSNK1G30.61008611
102VRK10.60876295
103SCYL20.59049275
104DDR20.56143763
105MET0.55578676
106MARK10.52624708
107CSNK1G10.51024713
108AURKA0.47568404
109DMPK0.47384414
110MAPK110.47153339
111ILK0.46371375
112IRAK30.46289888
113CDK11A0.46094029
114HIPK20.45940399
115CSNK1G20.45912229
116MAP3K80.45790259
117EIF2AK20.45209770
118RPS6KA50.45194734
119WNK40.45064314
120BMPR1B0.44722178
121PAK40.44327875
122LIMK10.44087388
123NME10.43916576
124TTN0.43789409
125BCR0.43374865
126MAPKAPK50.42518262
127CDK50.42433339
128NLK0.42072349
129ICK0.41778131
130CDK150.40280661
131PRKD20.38624400
132TRPM70.38511175
133ALK0.38475245
134FGR0.38269946
135CDK180.38141644
136PTK60.37999818
137MAP2K70.36858127
138PRKDC0.36234283
139TYRO30.36026495
140GRK10.35487650
141MAP3K40.33916762
142PIK3CG0.33716207
143ADRBK10.33162679
144PIM10.32388136
145CDK40.32315286
146PLK10.32006391
147RIPK40.31765959
148TESK20.31194228
149CDK190.31068484
150UHMK10.30783804
151PRKAA20.30396939
152EIF2AK30.30223354
153PLK20.30064958
154FGFR10.29925297
155MINK10.29897985
156CSNK1A1L0.29850961
157CDK140.29193750
158TRIM280.28927894
159MAPK100.28678435
160AKT20.27897664
161CDK30.27548934
162MAPK140.26658988
163GSK3B0.25824822
164MATK0.25179513
165CAMK1D0.21836362
166PRKCI0.21188378
167AKT10.20258050
168JAK20.18767001
169MAP3K100.17851398

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.40611043
2DNA replication_Homo sapiens_hsa030303.70393258
3Mismatch repair_Homo sapiens_hsa034303.51259776
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.29741535
5Ovarian steroidogenesis_Homo sapiens_hsa049132.95116900
6Homologous recombination_Homo sapiens_hsa034402.95012721
7Dorso-ventral axis formation_Homo sapiens_hsa043202.88498281
8One carbon pool by folate_Homo sapiens_hsa006702.84370973
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76565348
10GnRH signaling pathway_Homo sapiens_hsa049122.58537752
11Spliceosome_Homo sapiens_hsa030402.50832403
12Synaptic vesicle cycle_Homo sapiens_hsa047212.38787068
13Oxidative phosphorylation_Homo sapiens_hsa001902.33361764
14Proteasome_Homo sapiens_hsa030502.31136150
15RNA transport_Homo sapiens_hsa030132.31129591
16Circadian rhythm_Homo sapiens_hsa047102.28809309
17Fanconi anemia pathway_Homo sapiens_hsa034602.26905868
18RNA polymerase_Homo sapiens_hsa030202.23862247
19Base excision repair_Homo sapiens_hsa034102.13009010
20Nucleotide excision repair_Homo sapiens_hsa034202.09862053
21Ether lipid metabolism_Homo sapiens_hsa005652.07054508
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96688196
23Linoleic acid metabolism_Homo sapiens_hsa005911.92893300
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.85411194
25Oocyte meiosis_Homo sapiens_hsa041141.83650189
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80708498
27Collecting duct acid secretion_Homo sapiens_hsa049661.72778688
28Parkinsons disease_Homo sapiens_hsa050121.69670324
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66346898
30Pyruvate metabolism_Homo sapiens_hsa006201.64641863
31Pyrimidine metabolism_Homo sapiens_hsa002401.64394873
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60791940
33Salivary secretion_Homo sapiens_hsa049701.60107500
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.58813823
35Biosynthesis of amino acids_Homo sapiens_hsa012301.58484591
36Alzheimers disease_Homo sapiens_hsa050101.56274775
37Phototransduction_Homo sapiens_hsa047441.55101282
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54885791
39Olfactory transduction_Homo sapiens_hsa047401.52207186
40Mineral absorption_Homo sapiens_hsa049781.51784904
41Cardiac muscle contraction_Homo sapiens_hsa042601.49848641
42Non-homologous end-joining_Homo sapiens_hsa034501.49465721
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48316247
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46496399
45Histidine metabolism_Homo sapiens_hsa003401.44413513
46Carbon metabolism_Homo sapiens_hsa012001.43242349
47Sphingolipid metabolism_Homo sapiens_hsa006001.42237050
48Renal cell carcinoma_Homo sapiens_hsa052111.41860691
49Cell cycle_Homo sapiens_hsa041101.41547627
50Protein export_Homo sapiens_hsa030601.41399535
51Huntingtons disease_Homo sapiens_hsa050161.39920711
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35656181
53mRNA surveillance pathway_Homo sapiens_hsa030151.32281097
54Glioma_Homo sapiens_hsa052141.32129699
55TGF-beta signaling pathway_Homo sapiens_hsa043501.29759508
56Pancreatic cancer_Homo sapiens_hsa052121.29335588
57Sulfur relay system_Homo sapiens_hsa041221.27982660
58Axon guidance_Homo sapiens_hsa043601.24750337
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24396146
60Glutamatergic synapse_Homo sapiens_hsa047241.22890337
61Bladder cancer_Homo sapiens_hsa052191.22874240
62Long-term potentiation_Homo sapiens_hsa047201.21636229
63Choline metabolism in cancer_Homo sapiens_hsa052311.14596743
64Fatty acid elongation_Homo sapiens_hsa000621.13966380
65Purine metabolism_Homo sapiens_hsa002301.12586123
66Oxytocin signaling pathway_Homo sapiens_hsa049211.09717878
67VEGF signaling pathway_Homo sapiens_hsa043701.09447632
68Serotonergic synapse_Homo sapiens_hsa047261.08966498
69MicroRNAs in cancer_Homo sapiens_hsa052061.08751201
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08127223
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.05530709
72ErbB signaling pathway_Homo sapiens_hsa040121.03649158
73Steroid biosynthesis_Homo sapiens_hsa001001.02996935
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02972246
75Ras signaling pathway_Homo sapiens_hsa040141.01330155
76Long-term depression_Homo sapiens_hsa047300.99973271
77p53 signaling pathway_Homo sapiens_hsa041150.99062705
78Melanoma_Homo sapiens_hsa052180.98843443
79Propanoate metabolism_Homo sapiens_hsa006400.96402783
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94263554
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.93915317
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.93065421
83Vibrio cholerae infection_Homo sapiens_hsa051100.89423823
84Gastric acid secretion_Homo sapiens_hsa049710.88751291
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88577729
86Selenocompound metabolism_Homo sapiens_hsa004500.85398460
87Folate biosynthesis_Homo sapiens_hsa007900.85337096
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83379237
89Non-small cell lung cancer_Homo sapiens_hsa052230.81639503
90Estrogen signaling pathway_Homo sapiens_hsa049150.81483917
91Glutathione metabolism_Homo sapiens_hsa004800.78466721
92Vitamin B6 metabolism_Homo sapiens_hsa007500.77503800
93Thyroid hormone synthesis_Homo sapiens_hsa049180.76492569
94Pentose phosphate pathway_Homo sapiens_hsa000300.76152080
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75282104
96Nicotine addiction_Homo sapiens_hsa050330.75196668
97Circadian entrainment_Homo sapiens_hsa047130.73845896
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73666818
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73554100
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72663128
101Metabolic pathways_Homo sapiens_hsa011000.71849736
102cAMP signaling pathway_Homo sapiens_hsa040240.70681644
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68481824
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68351261
105Arachidonic acid metabolism_Homo sapiens_hsa005900.68203377
106Thyroid cancer_Homo sapiens_hsa052160.67439204
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66323896
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65993328
109Prostate cancer_Homo sapiens_hsa052150.65532137
110Autoimmune thyroid disease_Homo sapiens_hsa053200.65065452
111Fructose and mannose metabolism_Homo sapiens_hsa000510.63933533
112Endocytosis_Homo sapiens_hsa041440.63678366
113Melanogenesis_Homo sapiens_hsa049160.63510470
114Amphetamine addiction_Homo sapiens_hsa050310.62426282
115Dopaminergic synapse_Homo sapiens_hsa047280.62060155
116Vitamin digestion and absorption_Homo sapiens_hsa049770.61331075
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60527078
118Basal transcription factors_Homo sapiens_hsa030220.59859083
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59527010
120Glucagon signaling pathway_Homo sapiens_hsa049220.57547646
121Arginine and proline metabolism_Homo sapiens_hsa003300.57480298
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56344534
123Renin secretion_Homo sapiens_hsa049240.55752481
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54712544
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54313120
126Cholinergic synapse_Homo sapiens_hsa047250.53962422
127Calcium signaling pathway_Homo sapiens_hsa040200.53826665
128Prolactin signaling pathway_Homo sapiens_hsa049170.53752118
129MAPK signaling pathway_Homo sapiens_hsa040100.52977120
130Fatty acid metabolism_Homo sapiens_hsa012120.52374917
131Fat digestion and absorption_Homo sapiens_hsa049750.52032648
132Butanoate metabolism_Homo sapiens_hsa006500.51946824
133Pancreatic secretion_Homo sapiens_hsa049720.51821908
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51630278
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50732822
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50607601
137Insulin signaling pathway_Homo sapiens_hsa049100.49892332
138Glycerolipid metabolism_Homo sapiens_hsa005610.49859573
139Tight junction_Homo sapiens_hsa045300.49180747
140RNA degradation_Homo sapiens_hsa030180.48976795
141Protein digestion and absorption_Homo sapiens_hsa049740.46734322
142Inositol phosphate metabolism_Homo sapiens_hsa005620.45937416
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45237168
144Phenylalanine metabolism_Homo sapiens_hsa003600.44792522
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44313620
146Arginine biosynthesis_Homo sapiens_hsa002200.42787777
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42272998
148FoxO signaling pathway_Homo sapiens_hsa040680.41761555
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41609938
150Phagosome_Homo sapiens_hsa041450.41397658
151N-Glycan biosynthesis_Homo sapiens_hsa005100.39346430
152Tyrosine metabolism_Homo sapiens_hsa003500.39134865
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36834861
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36443162
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.35222744
156Epstein-Barr virus infection_Homo sapiens_hsa051690.28032334
157Galactose metabolism_Homo sapiens_hsa000520.27329889
158Peroxisome_Homo sapiens_hsa041460.25587075
159Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24866289
160Acute myeloid leukemia_Homo sapiens_hsa052210.23840374
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.22073799
162Viral carcinogenesis_Homo sapiens_hsa052030.20786544
163HIF-1 signaling pathway_Homo sapiens_hsa040660.20765208
164Chronic myeloid leukemia_Homo sapiens_hsa052200.19783957
165Lysine degradation_Homo sapiens_hsa003100.19042107
166Drug metabolism - other enzymes_Homo sapiens_hsa009830.18200199
167SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14731490
168Cyanoamino acid metabolism_Homo sapiens_hsa004600.14424459
169Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11438911
170Colorectal cancer_Homo sapiens_hsa052100.08686206
171Alcoholism_Homo sapiens_hsa050340.06747622
172Sulfur metabolism_Homo sapiens_hsa009200.05200124
173Basal cell carcinoma_Homo sapiens_hsa052170.02374073
174Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.02138382
175Wnt signaling pathway_Homo sapiens_hsa043100.01789548
176Nitrogen metabolism_Homo sapiens_hsa009100.01104796
177Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.00519514

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