NMUR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of immunoglobulin production (GO:0002639)9.27305447
2regulation of immunoglobulin secretion (GO:0051023)9.12154174
3positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)8.36841588
4regulation of macrophage activation (GO:0043030)7.68859912
5signal peptide processing (GO:0006465)7.38491584
6regulation of transforming growth factor beta production (GO:0071634)7.37474465
7positive regulation of B cell proliferation (GO:0030890)7.36246859
8regulation of immunoglobulin production (GO:0002637)7.09048916
9regulation of tumor necrosis factor biosynthetic process (GO:0042534)7.06455891
10regulation of granulocyte differentiation (GO:0030852)6.81454140
11serotonin metabolic process (GO:0042428)6.64714496
12tyrosine phosphorylation of STAT protein (GO:0007260)6.47603041
13tolerance induction (GO:0002507)6.38079467
14positive regulation of chemokine secretion (GO:0090197)6.26124371
15positive regulation of organelle assembly (GO:1902117)5.85251108
16regulation of transforming growth factor beta1 production (GO:0032908)5.81283305
17regulation of chemokine secretion (GO:0090196)5.62558153
18primary amino compound metabolic process (GO:1901160)5.60445308
19regulation of B cell proliferation (GO:0030888)5.56911134
20activated T cell proliferation (GO:0050798)5.45981663
21mammary gland alveolus development (GO:0060749)5.19778450
22positive regulation of JAK-STAT cascade (GO:0046427)5.03123878
23positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.99153520
24positive regulation of production of molecular mediator of immune response (GO:0002702)4.92169672
25positive regulation of B cell activation (GO:0050871)4.74797887
26negative regulation of cell killing (GO:0031342)4.72118496
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72118496
28viral protein processing (GO:0019082)4.49569049
29proline biosynthetic process (GO:0006561)4.44707735
30bone remodeling (GO:0046849)4.41992432
31fucose catabolic process (GO:0019317)4.40816518
32L-fucose metabolic process (GO:0042354)4.40816518
33L-fucose catabolic process (GO:0042355)4.40816518
34cellular response to interleukin-15 (GO:0071350)4.37488530
35response to interleukin-15 (GO:0070672)4.35857193
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21726768
37regulation of JAK-STAT cascade (GO:0046425)4.07978659
38negative regulation of T-helper cell differentiation (GO:0045623)4.03973150
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.03973150
40regulation of B cell receptor signaling pathway (GO:0050855)3.99785694
41interferon-gamma production (GO:0032609)3.96112049
42indolalkylamine metabolic process (GO:0006586)3.94490985
43regulation of production of molecular mediator of immune response (GO:0002700)3.85548870
44negative regulation of meiosis (GO:0045835)3.81537651
45CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.81352719
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.78887736
47behavioral response to nicotine (GO:0035095)3.76612889
48positive regulation of protein homooligomerization (GO:0032464)3.72027599
49positive regulation of gamma-delta T cell activation (GO:0046645)3.69349774
50CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.67965471
51T-helper cell differentiation (GO:0042093)3.67965471
52peptidyl-glutamic acid carboxylation (GO:0017187)3.67334384
53protein carboxylation (GO:0018214)3.67334384
54platelet dense granule organization (GO:0060155)3.62287429
55regulation of B cell activation (GO:0050864)3.60129165
56negative regulation of interleukin-12 production (GO:0032695)3.59997180
57DNA deamination (GO:0045006)3.56514967
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53602193
59negative regulation of epithelial cell differentiation (GO:0030857)3.51573836
60antigen processing and presentation of endogenous antigen (GO:0019883)3.47934059
61regulation of membrane protein ectodomain proteolysis (GO:0051043)3.43824632
62muscle organ morphogenesis (GO:0048644)3.43801231
63regulation of isotype switching to IgG isotypes (GO:0048302)3.42180705
64cellular biogenic amine biosynthetic process (GO:0042401)3.39896206
65amine biosynthetic process (GO:0009309)3.39896206
66regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.39423725
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37495826
68T cell migration (GO:0072678)3.36375728
69positive regulation of calcium ion transport into cytosol (GO:0010524)3.35585950
70positive regulation of Rho protein signal transduction (GO:0035025)3.34427650
71negative regulation of nitric oxide biosynthetic process (GO:0045019)3.34151621
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.28630217
73negative T cell selection (GO:0043383)3.28282662
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26615655
75response to protozoan (GO:0001562)3.26608807
76positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.25853788
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.23969650
78regulation of chronic inflammatory response (GO:0002676)3.23418743
79negative regulation of adaptive immune response (GO:0002820)3.19404646
80defense response to protozoan (GO:0042832)3.17924481
81negative regulation of acute inflammatory response (GO:0002674)3.17463819
82proline metabolic process (GO:0006560)3.15911747
83response to pheromone (GO:0019236)3.15723690
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.12165714
85alpha-beta T cell activation involved in immune response (GO:0002287)3.12165714
86T cell differentiation involved in immune response (GO:0002292)3.12165714
87negative regulation of JAK-STAT cascade (GO:0046426)3.12016209
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11225374
89regulation of T cell mediated cytotoxicity (GO:0001914)3.10695521
90regulation of gamma-delta T cell activation (GO:0046643)3.09794299
91embryonic process involved in female pregnancy (GO:0060136)3.07902794
92positive regulation of myeloid leukocyte differentiation (GO:0002763)3.05723282
93regulation of gamma-delta T cell differentiation (GO:0045586)3.04687137
94cytokine production involved in immune response (GO:0002367)3.02513609
95positive regulation of protein secretion (GO:0050714)3.01763300
96negative regulation of mast cell activation (GO:0033004)2.98607986
97adaptation of signaling pathway (GO:0023058)2.98279309
98positive regulation of lymphocyte proliferation (GO:0050671)2.96662314
99neural tube formation (GO:0001841)2.95498303
100virion assembly (GO:0019068)2.94233279
101protein localization to endosome (GO:0036010)2.94072677
102positive regulation of mononuclear cell proliferation (GO:0032946)2.93215020
103negative regulation of T cell mediated immunity (GO:0002710)2.92299647
104positive regulation of macrophage differentiation (GO:0045651)2.90097281
105bone resorption (GO:0045453)2.86556037
106positive regulation of leukocyte proliferation (GO:0070665)2.85170736
107cytidine metabolic process (GO:0046087)2.80713948
108cytidine catabolic process (GO:0006216)2.80713948
109cytidine deamination (GO:0009972)2.80713948
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80673721
111neutrophil activation (GO:0042119)2.79672674
112regulation of T cell tolerance induction (GO:0002664)2.78726791
113regulation of protein homooligomerization (GO:0032462)2.78711036
114regulation of T-helper 1 type immune response (GO:0002825)2.76742399
115regulation of interleukin-13 production (GO:0032656)2.76324136
116regulation of memory T cell differentiation (GO:0043380)2.76098769
117indole-containing compound catabolic process (GO:0042436)2.75888745
118indolalkylamine catabolic process (GO:0046218)2.75888745
119tryptophan catabolic process (GO:0006569)2.75888745
120detection of light stimulus involved in visual perception (GO:0050908)2.75025064
121detection of light stimulus involved in sensory perception (GO:0050962)2.75025064
122cellular response to mechanical stimulus (GO:0071260)2.73477357
123positive regulation of mast cell activation (GO:0033005)2.72710291
124mast cell activation involved in immune response (GO:0002279)2.72475168
125mast cell degranulation (GO:0043303)2.72475168
126negative regulation of interleukin-1 production (GO:0032692)2.72417788
127regulation of mast cell activation (GO:0033003)2.71925031
128fucosylation (GO:0036065)2.70794486
129cellular extravasation (GO:0045123)2.70611204
130negative thymic T cell selection (GO:0045060)2.69104883
131regulation of regulatory T cell differentiation (GO:0045589)2.68003701
132detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67202176
133leukocyte aggregation (GO:0070486)2.66081768
134negative regulation of meiotic cell cycle (GO:0051447)2.65172304
135microglial cell activation (GO:0001774)2.63945046
136positive regulation of tolerance induction (GO:0002645)2.63892027
137negative regulation of interleukin-1 beta production (GO:0032691)2.63705555
138regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62793233
139regulation of interleukin-5 production (GO:0032674)2.62588226
140regulation of B cell differentiation (GO:0045577)2.61610315
141positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.60548969
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60460104
143antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60460104
144positive regulation of chemokine biosynthetic process (GO:0045080)2.59644136
145negative regulation of osteoclast differentiation (GO:0045671)2.59198197
146preassembly of GPI anchor in ER membrane (GO:0016254)2.57938390
147pyrimidine ribonucleoside catabolic process (GO:0046133)2.57905121
148indole-containing compound metabolic process (GO:0042430)2.57266618
149negative regulation of cAMP-mediated signaling (GO:0043951)2.57247107
150positive thymic T cell selection (GO:0045059)2.56836094
151interferon-gamma secretion (GO:0072643)2.56202668
152sulfation (GO:0051923)2.55425884
153thymic T cell selection (GO:0045061)2.55177185
154regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53034433
155regulation of natural killer cell mediated immunity (GO:0002715)2.53034433
156positive regulation of defense response to virus by host (GO:0002230)2.52991117
157mast cell activation (GO:0045576)2.52807800
158piRNA metabolic process (GO:0034587)2.52034107
159negative regulation of calcium ion transport into cytosol (GO:0010523)2.50470257
160positive T cell selection (GO:0043368)2.48980032
161parturition (GO:0007567)2.48705052
162regulation of tolerance induction (GO:0002643)2.48046349
163regulation of cell killing (GO:0031341)2.45909091
164tryptophan metabolic process (GO:0006568)2.42556264
165neutrophil activation involved in immune response (GO:0002283)2.42538734
166phosphatidylinositol acyl-chain remodeling (GO:0036149)2.41824574
167cellular ketone body metabolic process (GO:0046950)2.41223489
168leukocyte degranulation (GO:0043299)2.40210360
169response to interferon-beta (GO:0035456)2.39656585
170superoxide anion generation (GO:0042554)2.39518074
171positive regulation of cell killing (GO:0031343)2.38609042
172negative regulation of leukocyte mediated immunity (GO:0002704)2.38230147
173regulation of T cell mediated immunity (GO:0002709)2.37421774
174immunoglobulin mediated immune response (GO:0016064)2.35898242
175regulation of alpha-beta T cell proliferation (GO:0046640)2.33540095
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33425405
177regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.32952338
178axoneme assembly (GO:0035082)2.32544816
179tachykinin receptor signaling pathway (GO:0007217)2.31773912
180neutrophil mediated immunity (GO:0002446)2.30285359
181killing of cells of other organism (GO:0031640)2.29788975
182disruption of cells of other organism (GO:0044364)2.29788975
183cell wall macromolecule catabolic process (GO:0016998)2.29786696
184T cell proliferation (GO:0042098)2.29579923
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29089260
186positive regulation of macrophage activation (GO:0043032)15.4106234
187regulation of podosome assembly (GO:0071801)15.2109673
188positive regulation of granulocyte differentiation (GO:0030854)11.3600277
189regulation of proton transport (GO:0010155)11.1647904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43329479
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.08052444
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.83587318
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.04255317
5ZNF274_21170338_ChIP-Seq_K562_Hela3.39943767
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.18485623
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.14662277
8VDR_21846776_ChIP-Seq_THP-1_Human3.05831306
9VDR_22108803_ChIP-Seq_LS180_Human2.77632961
10* RUNX_20019798_ChIP-Seq_JUKART_Human2.73581743
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.69023453
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63812351
13MYC_22102868_ChIP-Seq_BL_Human2.54910831
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53635438
15MAF_26560356_Chip-Seq_TH1_Human2.50341463
16LXR_22292898_ChIP-Seq_THP-1_Human2.49484283
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37635475
18EZH2_22144423_ChIP-Seq_EOC_Human2.31303243
19KDM2B_26808549_Chip-Seq_DND41_Human2.25264312
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19773261
21MYB_26560356_Chip-Seq_TH2_Human2.17796535
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.11474499
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10546542
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09641891
25* RUNX1_22412390_ChIP-Seq_EML_Mouse2.05906300
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02580467
27GBX2_23144817_ChIP-Seq_PC3_Human1.99732313
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99646751
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92687086
30* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.89674807
31MYB_26560356_Chip-Seq_TH1_Human1.89237238
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87571369
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87237330
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86950304
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84781921
36* VDR_24763502_ChIP-Seq_THP-1_Human1.83569902
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.83516014
38MAF_26560356_Chip-Seq_TH2_Human1.82836155
39TCF7_22412390_ChIP-Seq_EML_Mouse1.81929778
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80887621
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.79903891
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76953198
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76953198
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76953198
45UTX_26944678_Chip-Seq_JUKART_Human1.76944174
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76435556
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.75578542
48BCAT_22108803_ChIP-Seq_LS180_Human1.74306756
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70296728
50ER_23166858_ChIP-Seq_MCF-7_Human1.68822408
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.68512454
52GATA1_19941826_ChIP-Seq_K562_Human1.67190302
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62576746
54TAF15_26573619_Chip-Seq_HEK293_Human1.59103256
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55359229
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53972613
57IGF1R_20145208_ChIP-Seq_DFB_Human1.53710252
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49174462
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49072352
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48978857
61TP53_22573176_ChIP-Seq_HFKS_Human1.48402092
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.48261077
63* KDM2B_26808549_Chip-Seq_JURKAT_Human1.47771370
64RACK7_27058665_Chip-Seq_MCF-7_Human1.45887968
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45002602
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44089199
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43881989
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42682425
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40878751
70* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40559030
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.38636305
72IRF1_19129219_ChIP-ChIP_H3396_Human1.37929232
73P300_19829295_ChIP-Seq_ESCs_Human1.36622142
74* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36535342
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36101010
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34510402
77* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34139108
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32590408
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31704466
80* GATA3_26560356_Chip-Seq_TH2_Human1.31209027
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30160496
82ERA_21632823_ChIP-Seq_H3396_Human1.29580791
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29157535
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28639780
85REST_21632747_ChIP-Seq_MESCs_Mouse1.28605965
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28384546
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28134930
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27606657
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27595895
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.27595895
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.25945202
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.24730398
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24536092
94* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24181970
95SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.23443151
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22339963
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21337904
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20831672
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.20815104
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20159489
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20072769
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20056574
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19954285
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19750941
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19266254
106GATA2_19941826_ChIP-Seq_K562_Human1.19023789
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18281805
108NANOG_20526341_ChIP-Seq_ESCs_Human1.18264179
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18052172
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15752912
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15752912
112TCF4_23295773_ChIP-Seq_U87_Human1.13980392
113EGR1_19032775_ChIP-ChIP_M12_Human1.13527724
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13320304
115AR_25329375_ChIP-Seq_VCAP_Human1.13048567
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12996335
117CBP_20019798_ChIP-Seq_JUKART_Human1.12996335
118SMRT_27268052_Chip-Seq_Bcells_Human1.12902554
119FUS_26573619_Chip-Seq_HEK293_Human1.12557318
120* STAT3_23295773_ChIP-Seq_U87_Human1.12203542
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12109186
122NCOR_22424771_ChIP-Seq_293T_Human1.11854906
123* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11720259
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11676829
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10871121
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10517469
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10063504
128AR_20517297_ChIP-Seq_VCAP_Human1.09935766
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09868178
130TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09755583
131* TAF2_19829295_ChIP-Seq_ESCs_Human1.08983282
132GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07104425
133FOXH1_21741376_ChIP-Seq_EPCs_Human1.03917509
134NANOG_19829295_ChIP-Seq_ESCs_Human1.03667820
135SOX2_19829295_ChIP-Seq_ESCs_Human1.03667820
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03646472
137* NFE2_27457419_Chip-Seq_LIVER_Mouse1.03625640
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.03125233
139TCF4_22108803_ChIP-Seq_LS180_Human1.03057199
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02829849
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02714712
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02613430
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02399127
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02270137
145IRF8_27001747_Chip-Seq_BMDM_Mouse1.02043185
146EWS_26573619_Chip-Seq_HEK293_Human1.01906113
147* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01751208
148* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01568325
149MYC_19829295_ChIP-Seq_ESCs_Human1.01142229
150FLI1_21867929_ChIP-Seq_TH2_Mouse1.01003880
151NCOR1_26117541_ChIP-Seq_K562_Human1.00557451
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00511408
153CTCF_21964334_Chip-Seq_Bcells_Human1.00207245
154OCT4_20526341_ChIP-Seq_ESCs_Human0.99865332
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.99643314
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99617643
157RUNX2_22187159_ChIP-Seq_PCA_Human0.97859058
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97834560
159KDM2B_26808549_Chip-Seq_K562_Human0.97484264
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97414701
161STAT1_20625510_ChIP-Seq_HELA_Human0.97394226
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96930855
163RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96715141
164NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96559895
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95946057
166CEBPB_22108803_ChIP-Seq_LS180_Human0.94989696
167* EZH2_27294783_Chip-Seq_NPCs_Mouse0.94611154
168FOXH1_21741376_ChIP-Seq_ESCs_Human0.94086796
169HOXB7_26014856_ChIP-Seq_BT474_Human0.93749653
170PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93515418
171ETS1_21867929_ChIP-Seq_TH2_Mouse0.93490703
172GATA1_19941827_ChIP-Seq_MEL_Mouse0.92886454
173BCOR_27268052_Chip-Seq_Bcells_Human0.92103500
174* RARB_24833708_ChIP-Seq_LIVER_Mouse0.91092363
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.89451087
176GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.88493094
177ELF1_20517297_ChIP-Seq_JURKAT_Human0.87051965
178KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87023757
179SMC4_20622854_ChIP-Seq_HELA_Human0.86100483
180CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85969286
181CTCF_27219007_Chip-Seq_Bcells_Human0.85753109
182SA1_27219007_Chip-Seq_Bcells_Human0.85607651
183TP53_20018659_ChIP-ChIP_R1E_Mouse0.83011764
184SCL_19346495_ChIP-Seq_HPC-7_Human0.82533298
185SPI1_23127762_ChIP-Seq_K562_Human0.82363976
186DROSHA_22980978_ChIP-Seq_HELA_Human0.82253231
187FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82041239
188UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81488448
189* GATA3_27048872_Chip-Seq_THYMUS_Human0.81468929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003045_fibrosis7.69014661
2MP0005671_abnormal_response_to4.12061970
3MP0001835_abnormal_antigen_presentation3.67488826
4MP0004510_myositis3.54288968
5MP0001790_abnormal_immune_system3.29238511
6MP0005387_immune_system_phenotype3.29238511
7MP0008775_abnormal_heart_ventricle3.08254351
8MP0003724_increased_susceptibility_to3.04647362
9MP0001800_abnormal_humoral_immune2.82654756
10MP0005166_decreased_susceptibility_to2.74871172
11MP0001348_abnormal_lacrimal_gland2.63118618
12MP0009278_abnormal_bone_marrow2.61438287
13MP0001873_stomach_inflammation2.54227265
14MP0000685_abnormal_immune_system2.47633458
15MP0002168_other_aberrant_phenotype2.43875917
16MP0002933_joint_inflammation2.28265204
17MP0005000_abnormal_immune_tolerance2.25284712
18MP0006082_CNS_inflammation2.23237174
19MP0005623_abnormal_meninges_morphology2.05608863
20MP0001986_abnormal_taste_sensitivity2.05259963
21MP0003763_abnormal_thymus_physiology2.01486746
22MP0005025_abnormal_response_to1.98956514
23MP0001501_abnormal_sleep_pattern1.97732416
24MP0003300_gastrointestinal_ulcer1.96261265
25MP0003303_peritoneal_inflammation1.96029985
26MP0000569_abnormal_digit_pigmentation1.94942114
27MP0002723_abnormal_immune_serum1.91530361
28MP0005551_abnormal_eye_electrophysiolog1.89173106
29MP0003195_calcinosis1.87593752
30MP0001968_abnormal_touch/_nociception1.87122553
31MP0009333_abnormal_splenocyte_physiolog1.86497258
32MP0002876_abnormal_thyroid_physiology1.80698415
33MP0000477_abnormal_intestine_morphology1.80675072
34MP0003183_abnormal_peptide_metabolism1.79153498
35MP0001545_abnormal_hematopoietic_system1.78672303
36MP0005397_hematopoietic_system_phenotyp1.78672303
37MP0002420_abnormal_adaptive_immunity1.76279167
38MP0001819_abnormal_immune_cell1.75933981
39* MP0002733_abnormal_thermal_nociception1.74515508
40MP0005310_abnormal_salivary_gland1.73287776
41MP0002398_abnormal_bone_marrow1.71001474
42MP0002452_abnormal_antigen_presenting1.70034864
43MP0004142_abnormal_muscle_tone1.69315810
44MP0005645_abnormal_hypothalamus_physiol1.65167281
45MP0005084_abnormal_gallbladder_morpholo1.64969808
46MP0000465_gastrointestinal_hemorrhage1.63293000
47MP0003787_abnormal_imprinting1.61729580
48MP0003866_abnormal_defecation1.59327496
49MP0000716_abnormal_immune_system1.52061481
50MP0002928_abnormal_bile_duct1.51982776
51MP0005076_abnormal_cell_differentiation1.51426743
52MP0003436_decreased_susceptibility_to1.51338139
53MP0010155_abnormal_intestine_physiology1.51136958
54MP0005174_abnormal_tail_pigmentation1.49524801
55MP0008057_abnormal_DNA_replication1.49311043
56* MP0001970_abnormal_pain_threshold1.49262174
57MP0002277_abnormal_respiratory_mucosa1.48598246
58MP0003646_muscle_fatigue1.42993048
59MP0002736_abnormal_nociception_after1.41432395
60MP0002405_respiratory_system_inflammati1.40791737
61MP0004947_skin_inflammation1.40768082
62MP0004130_abnormal_muscle_cell1.38706689
63MP0004264_abnormal_extraembryonic_tissu1.38589324
64MP0005075_abnormal_melanosome_morpholog1.37587306
65MP0002102_abnormal_ear_morphology1.37198827
66MP0004043_abnormal_pH_regulation1.36584571
67MP0005377_hearing/vestibular/ear_phenot1.36262371
68MP0003878_abnormal_ear_physiology1.36262371
69MP0004134_abnormal_chest_morphology1.36081897
70MP0002148_abnormal_hypersensitivity_rea1.34077619
71MP0002396_abnormal_hematopoietic_system1.33039460
72MP0000490_abnormal_crypts_of1.32803795
73MP0003011_delayed_dark_adaptation1.31560250
74MP0006292_abnormal_olfactory_placode1.31428639
75MP0002009_preneoplasia1.30489047
76MP0008872_abnormal_physiological_respon1.29775975
77MP0002429_abnormal_blood_cell1.28556607
78MP0009764_decreased_sensitivity_to1.28304420
79MP0002909_abnormal_adrenal_gland1.28240435
80MP0001845_abnormal_inflammatory_respons1.27157971
81MP0002722_abnormal_immune_system1.25986958
82MP0003252_abnormal_bile_duct1.25286787
83MP0005464_abnormal_platelet_physiology1.22628270
84MP0000703_abnormal_thymus_morphology1.22223965
85MP0002282_abnormal_trachea_morphology1.22168420
86MP0002138_abnormal_hepatobiliary_system1.21988595
87MP0001853_heart_inflammation1.21360211
88MP0002653_abnormal_ependyma_morphology1.16874681
89MP0002163_abnormal_gland_morphology1.16552912
90MP0000372_irregular_coat_pigmentation1.15319497
91MP0005395_other_phenotype1.11584146
92MP0009745_abnormal_behavioral_response1.11170370
93MP0005253_abnormal_eye_physiology1.10729026
94MP0002693_abnormal_pancreas_physiology1.10560325
95MP0004742_abnormal_vestibular_system1.10314860
96MP0009046_muscle_twitch1.09001014
97MP0005167_abnormal_blood-brain_barrier1.08492152
98MP0005379_endocrine/exocrine_gland_phen1.06712486
99MP0006276_abnormal_autonomic_nervous1.06597405
100MP0008875_abnormal_xenobiotic_pharmacok1.06323849
101MP0010329_abnormal_lipoprotein_level1.04614586
102MP0001919_abnormal_reproductive_system1.02539259
103MP0003566_abnormal_cell_adhesion1.01950770
104MP0002272_abnormal_nervous_system1.01608477
105MP0002837_dystrophic_cardiac_calcinosis1.01225999
106MP0005165_increased_susceptibility_to1.00755321
107MP0001533_abnormal_skeleton_physiology0.97991096
108MP0002638_abnormal_pupillary_reflex0.97946350
109MP0005058_abnormal_lysosome_morphology0.97720070
110MP0001905_abnormal_dopamine_level0.97600860
111MP0000689_abnormal_spleen_morphology0.96787439
112MP0002735_abnormal_chemical_nociception0.93537116
113MP0009785_altered_susceptibility_to0.92725696
114MP0003448_altered_tumor_morphology0.91903297
115MP0000230_abnormal_systemic_arterial0.91438689
116MP0006072_abnormal_retinal_apoptosis0.89624481
117MP0001485_abnormal_pinna_reflex0.87849979
118MP0005389_reproductive_system_phenotype0.86919858
119MP0004133_heterotaxia0.86762383
120MP0004885_abnormal_endolymph0.86143131
121MP0001663_abnormal_digestive_system0.85407914
122MP0004883_abnormal_blood_vessel0.82435659
123MP0002064_seizures0.82191177
124MP0002419_abnormal_innate_immunity0.82134316
125MP0005332_abnormal_amino_acid0.82076997
126MP0005535_abnormal_body_temperature0.80998308
127MP0005085_abnormal_gallbladder_physiolo0.80952097
128MP0000343_altered_response_to0.78800789
129MP0000639_abnormal_adrenal_gland0.77613556
130MP0002086_abnormal_extraembryonic_tissu0.77189458
131MP0008469_abnormal_protein_level0.77094293
132MP0001943_abnormal_respiration0.77068517
133MP0003453_abnormal_keratinocyte_physiol0.77019650
134MP0005386_behavior/neurological_phenoty0.72433855
135MP0004924_abnormal_behavior0.72433855
136MP0005023_abnormal_wound_healing0.70786264
137MP0002998_abnormal_bone_remodeling0.70247790
138MP0003091_abnormal_cell_migration0.68996937
139MP0002166_altered_tumor_susceptibility0.67132245
140MP0001502_abnormal_circadian_rhythm0.64191913
141MP0000013_abnormal_adipose_tissue0.63163543
142MP0005381_digestive/alimentary_phenotyp0.62383312
143MP0001851_eye_inflammation0.61996930
144MP0005390_skeleton_phenotype0.60867985
145MP0009931_abnormal_skin_appearance0.60037752
146MP0004484_altered_response_of0.53002599
147MP0003075_altered_response_to0.52473313
148MP0002019_abnormal_tumor_incidence0.52370412
149MP0000470_abnormal_stomach_morphology0.51104789
150MP0008874_decreased_physiological_sensi0.49924169
151MP0008877_abnormal_DNA_methylation0.47880946
152MP0002572_abnormal_emotion/affect_behav0.42088290
153MP0003172_abnormal_lysosome_physiology0.41998082
154MP0004185_abnormal_adipocyte_glucose0.41528289
155MP0002113_abnormal_skeleton_development0.39501250
156MP0000598_abnormal_liver_morphology0.39302441
157MP0010352_gastrointestinal_tract_polyps0.38503543
158MP0005584_abnormal_enzyme/coenzyme_acti0.38273863

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.94382739
2Abnormality of B cell number (HP:0010975)4.94382739
3Pustule (HP:0200039)4.69140929
4IgM deficiency (HP:0002850)4.58982789
5Congenital stationary night blindness (HP:0007642)4.50465247
6Abnormal tarsal ossification (HP:0008369)4.32829189
7Epiphyseal dysplasia (HP:0002656)4.28260565
8Increased IgM level (HP:0003496)4.24975218
9IgA deficiency (HP:0002720)3.96717634
10Molar tooth sign on MRI (HP:0002419)3.83996139
11Abnormality of midbrain morphology (HP:0002418)3.83996139
12Recurrent bronchitis (HP:0002837)3.82315250
13Stomatitis (HP:0010280)3.79572420
14Vertebral hypoplasia (HP:0008417)3.76502438
15Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.76502438
16Irregular epiphyses (HP:0010582)3.75824803
17Abnormality of T cell physiology (HP:0011840)3.63277348
18Myositis (HP:0100614)3.61702559
19Cupped ribs (HP:0000887)3.55046172
20Pancreatic cysts (HP:0001737)3.50414267
21Flat acetabular roof (HP:0003180)3.21270016
22Abnormal foot bone ossification (HP:0010675)3.21045420
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20621740
24Abnormal rod and cone electroretinograms (HP:0008323)3.19186958
25Stomach cancer (HP:0012126)3.19063901
26Polydipsia (HP:0001959)3.16735401
27Abnormal drinking behavior (HP:0030082)3.16735401
28Ulnar bowing (HP:0003031)3.10708966
29Pancreatic fibrosis (HP:0100732)3.05690841
30Abnormality of T cells (HP:0002843)3.02766617
31Attenuation of retinal blood vessels (HP:0007843)2.95273363
32True hermaphroditism (HP:0010459)2.94611584
33Nephronophthisis (HP:0000090)2.94063006
34Joint stiffness (HP:0001387)2.89333203
35Gingival bleeding (HP:0000225)2.88844780
36Hypoplastic ischia (HP:0003175)2.75477606
37Hypomagnesemia (HP:0002917)2.75302741
38Abolished electroretinogram (ERG) (HP:0000550)2.69540835
39Hyperventilation (HP:0002883)2.68827970
40Petechiae (HP:0000967)2.68701875
41Small epiphyses (HP:0010585)2.68586566
42Ovoid vertebral bodies (HP:0003300)2.67877472
43Annular pancreas (HP:0001734)2.66760466
44Recurrent bacterial skin infections (HP:0005406)2.65543673
45Facial hemangioma (HP:0000329)2.63837232
46Premature skin wrinkling (HP:0100678)2.61508358
47Abnormal hemoglobin (HP:0011902)2.60690811
48Chronic mucocutaneous candidiasis (HP:0002728)2.59508364
49Recurrent cutaneous fungal infections (HP:0011370)2.59508364
50Abnormality of male internal genitalia (HP:0000022)2.57035104
51Decreased central vision (HP:0007663)2.55900101
52Abnormality of the renal medulla (HP:0100957)2.55816256
53Tetany (HP:0001281)2.55369378
54Obstructive lung disease (HP:0006536)2.55342022
55Chronic obstructive pulmonary disease (HP:0006510)2.55342022
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54341422
57Chronic hepatic failure (HP:0100626)2.52477056
58Polyuria (HP:0000103)2.51369442
59Recurrent abscess formation (HP:0002722)2.50604353
60Abnormal platelet volume (HP:0011876)2.50530038
61Eczematoid dermatitis (HP:0000976)2.50215299
62Poikiloderma (HP:0001029)2.49958912
63Optic neuritis (HP:0100653)2.49062150
64Retrobulbar optic neuritis (HP:0100654)2.49062150
65Recurrent fungal infections (HP:0002841)2.48636263
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48062974
67Vasculitis (HP:0002633)2.47383991
68Encephalitis (HP:0002383)2.42357584
69Chronic otitis media (HP:0000389)2.42022900
70Urinary glycosaminoglycan excretion (HP:0003541)2.41650235
71Mucopolysacchariduria (HP:0008155)2.41650235
72Abnormality of the renal cortex (HP:0011035)2.39780715
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37992547
74Hypochromic microcytic anemia (HP:0004840)2.35139844
75Hypergammaglobulinemia (HP:0010702)2.34504273
76Purpura (HP:0000979)2.34002552
77IgG deficiency (HP:0004315)2.33820238
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.33715867
79Vitreoretinal degeneration (HP:0000655)2.33165791
80Abnormality of the ischium (HP:0003174)2.33054594
81Keratoconjunctivitis (HP:0001096)2.31989416
82Progressive cerebellar ataxia (HP:0002073)2.31432842
83Elevated erythrocyte sedimentation rate (HP:0003565)2.30016811
84Abnormality of T cell number (HP:0011839)2.29948187
85Abnormality of macrophages (HP:0004311)2.29678635
86Concave nail (HP:0001598)2.28140642
87T lymphocytopenia (HP:0005403)2.27062060
88Panhypogammaglobulinemia (HP:0003139)2.20822741
89Increased mean platelet volume (HP:0011877)2.20817311
90Hypothermia (HP:0002045)2.17041628
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13572171
92Abnormality of polysaccharide metabolism (HP:0011012)2.13572171
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13572171
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.13558688
95Absent/shortened dynein arms (HP:0200106)2.13558688
96Cystic liver disease (HP:0006706)2.11474143
97Bony spicule pigmentary retinopathy (HP:0007737)2.10452014
98Pulmonary embolism (HP:0002204)2.07377509
99Recurrent skin infections (HP:0001581)2.06655555
100Type II lissencephaly (HP:0007260)2.06638209
101Severe combined immunodeficiency (HP:0004430)2.04984244
102Bowing of the arm (HP:0006488)2.04941562
103Bowed forearm bones (HP:0003956)2.04941562
104Episodic fever (HP:0001954)2.04822103
105Abnormal urine output (HP:0012590)2.03649697
106Thickened helices (HP:0000391)2.02848777
107Nasal polyposis (HP:0100582)2.02327168
108Broad alveolar ridges (HP:0000187)2.01423266
109Gastrointestinal stroma tumor (HP:0100723)2.01360167
110Large for gestational age (HP:0001520)2.00528390
111Gastrointestinal infarctions (HP:0005244)2.00390988
112Polyphagia (HP:0002591)2.00371079
113Decreased circulating renin level (HP:0003351)1.99426559
114Recurrent sinusitis (HP:0011108)1.99197747
115Polycythemia (HP:0001901)1.99186374
116Orchitis (HP:0100796)1.99152736
117Growth hormone excess (HP:0000845)1.98132903
118Abnormality of magnesium homeostasis (HP:0004921)1.98128771
119Medial flaring of the eyebrow (HP:0010747)1.97949867
120Rib fusion (HP:0000902)1.97783692
121Gaze-evoked nystagmus (HP:0000640)1.97358419
122Constricted visual fields (HP:0001133)1.97091904
123Joint swelling (HP:0001386)1.96768715
124Increased IgE level (HP:0003212)1.96003627
125Abnormality of carpal bone ossification (HP:0006257)1.94891183
126Inability to walk (HP:0002540)1.94840583
127Hypoproteinemia (HP:0003075)1.94755143
128Bronchitis (HP:0012387)1.94442725
129Meningitis (HP:0001287)1.94278593
130Cervical subluxation (HP:0003308)1.93779527
131Keratoconjunctivitis sicca (HP:0001097)1.93511975
132Hemiplegia (HP:0002301)1.93402577
133Anorexia (HP:0002039)1.92444134
134Hypercortisolism (HP:0001578)1.91565237
135Ulnar deviation of the wrist (HP:0003049)1.91458938
136Osteoarthritis (HP:0002758)1.91456933
137Tubular atrophy (HP:0000092)1.90901408
138Interstitial pulmonary disease (HP:0006530)1.89599456
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.89389650
140Abnormal biliary tract physiology (HP:0012439)1.88504033
141Bile duct proliferation (HP:0001408)1.88504033
142Clumsiness (HP:0002312)1.88019584
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87167958
144Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.86335644
145Dysostosis multiplex (HP:0000943)1.85930199
146Asplenia (HP:0001746)1.85420295
147Hypochromic anemia (HP:0001931)1.84964530
148Agitation (HP:0000713)1.84684780
149Thoracolumbar scoliosis (HP:0002944)1.84453767
150Hypotrichosis (HP:0001006)1.83685196
151Hemoptysis (HP:0002105)1.83653936
152Thyroid-stimulating hormone excess (HP:0002925)1.82934844
153Mild short stature (HP:0003502)1.82488586
154Alopecia of scalp (HP:0002293)1.82297853
155Increased corneal curvature (HP:0100692)1.81656858
156Keratoconus (HP:0000563)1.81656858
157Leukocytosis (HP:0001974)1.81514604
158Arthralgia (HP:0002829)1.80664674
159Menstrual irregularities (HP:0000858)1.80632182
160Gangrene (HP:0100758)1.80609747
161Pulmonary infiltrates (HP:0002113)1.80566559
162Hypoglycemic coma (HP:0001325)1.78332434
163Hypoplasia of the odontoid process (HP:0003311)1.78163075
164Hypobetalipoproteinemia (HP:0003563)1.77033112
165Thin ribs (HP:0000883)1.76741974
166Abnormality of renal excretion (HP:0011036)1.76573742
167Mediastinal lymphadenopathy (HP:0100721)1.76396101
168Congenital sensorineural hearing impairment (HP:0008527)1.76219982
169Dysautonomia (HP:0002459)1.75816723
170Cerebral aneurysm (HP:0004944)1.75633620
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.75178510
172Anencephaly (HP:0002323)1.72229726
173Absent speech (HP:0001344)1.71270721
174Recurrent gram-negative bacterial infections (HP:0005420)1.69804296
175Genetic anticipation (HP:0003743)1.69598320
176Prolonged bleeding time (HP:0003010)1.67651413
177Alveolar cell carcinoma (HP:0006519)1.67360816
178Hyperalaninemia (HP:0003348)1.63377842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.12805600
2MAP3K64.61787387
3FRK4.54513847
4MAP4K14.03072189
5DDR23.24402195
6ICK3.02180831
7ADRBK22.75946569
8MAP4K22.72728263
9ZAP702.58935493
10MAPK152.53747805
11GRK12.41724018
12BMPR1B2.21403289
13TAOK32.15267717
14WNK42.12205663
15MATK2.08153030
16BLK2.05722828
17PRKD22.05422330
18FGR2.04622356
19JAK11.90581652
20FES1.88191872
21UHMK11.88122968
22RIPK41.87914676
23EPHB11.81183338
24MAP2K31.80930844
25ZAK1.79080522
26TYRO31.75893598
27ACVR1B1.75494091
28CSK1.74347517
29KIT1.72687660
30BMX1.71911500
31JAK31.71712952
32MAPK131.64092803
33MAP3K111.61198364
34GRK61.58145314
35TLK11.55508582
36TRIB31.54520580
37WNK31.51704826
38NME11.45917143
39CDK61.37707543
40OXSR11.36785668
41IRAK41.35416081
42DAPK11.35017945
43SYK1.29684152
44DAPK21.29453962
45CAMKK21.27931386
46IKBKE1.26651926
47STK241.25944782
48PAK31.24746269
49LCK1.20416269
50ADRBK11.19801588
51MAP2K61.18160741
52SIK21.17212052
53TYK21.16343526
54ALK1.15908262
55NUAK11.15651510
56PTK2B1.14402013
57PINK11.12617538
58BTK1.11874627
59PIM11.09497116
60GSK3A1.08078747
61MAP3K31.07791778
62HCK1.07404357
63TNK21.06295270
64GRK71.01533457
65TESK20.95373064
66PRKCH0.92694046
67PIK3CG0.91346990
68MAP3K40.89314475
69MARK30.88106081
70SIK10.85521386
71STK100.83078406
72MAP3K100.80478159
73PTK20.78689580
74IKBKB0.78526336
75SIK30.78224204
76HIPK20.77428081
77STK390.75528379
78EPHA30.75494515
79LYN0.74806115
80ITK0.74705565
81INSRR0.74350188
82JAK20.73682761
83CAMKK10.73356513
84CDK40.72281792
85CDC42BPA0.71859367
86CASK0.71782642
87RPS6KC10.71751777
88RPS6KL10.71751777
89PDK10.71571423
90NTRK30.70809748
91YES10.70768875
92RET0.69533701
93FGFR40.68925432
94TRIM280.66602327
95TGFBR10.66397672
96MAPK110.65737483
97MST40.65723198
98MAP3K140.65432620
99GRK50.65296543
100IRAK10.65162339
101RPS6KA60.64943191
102MAPK40.64844024
103DYRK20.64652993
104STK110.63118518
105PASK0.61720836
106CSF1R0.60681732
107PIM20.60446000
108PRKCG0.59121361
109CAMK10.58995051
110MAP3K70.58977746
111PDPK10.58168681
112TEC0.57766166
113PRKCE0.57680448
114LRRK20.54943375
115TIE10.54637289
116AKT30.54382124
117PRKACG0.53770818
118PDGFRA0.52351335
119ILK0.52121060
120TBK10.52051629
121DMPK0.51877613
122MAP2K40.50936810
123TNIK0.50307992
124MAP2K20.49221610
125NME20.48693089
126PRKG20.48008822
127STK30.47716582
128PRKCD0.46943627
129MAP2K70.45865395
130BMPR20.44185969
131EEF2K0.43816956
132PRKCI0.42669427
133CDK150.42099791
134NLK0.41746889
135CDK180.41214884
136CDK30.40454144
137MINK10.40217003
138PRKCQ0.39742869
139RIPK10.39628751
140CDK11A0.39495433
141PRKCZ0.39121153
142BCKDK0.38199999
143PKN10.38183538
144PRKACA0.38090242
145MAPK30.37688137
146DYRK1B0.37505008
147PRKG10.36114883
148TAOK10.35973005
149PHKG20.35698039
150PHKG10.35698039
151KDR0.35038758
152IGF1R0.34660003
153TGFBR20.33635621
154INSR0.32363319
155RPS6KA10.31015976
156TRPM70.30327912
157PDGFRB0.29363061
158ABL10.29003830
159FGFR10.28612883
160PAK60.28423046

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053306.04682174
2Autoimmune thyroid disease_Homo sapiens_hsa053205.06101266
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.16921655
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.01329623
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046643.13060122
6Graft-versus-host disease_Homo sapiens_hsa053323.01926854
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59784553
8Linoleic acid metabolism_Homo sapiens_hsa005912.33249047
9Phototransduction_Homo sapiens_hsa047442.20296040
10Type I diabetes mellitus_Homo sapiens_hsa049402.10644678
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00160724
12Asthma_Homo sapiens_hsa0531011.3753276
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94348078
14Hematopoietic cell lineage_Homo sapiens_hsa046401.88619039
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.87641064
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77502468
17T cell receptor signaling pathway_Homo sapiens_hsa046601.75367484
18* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69705713
19Staphylococcus aureus infection_Homo sapiens_hsa051501.62484977
20Antigen processing and presentation_Homo sapiens_hsa046121.58427502
21Ether lipid metabolism_Homo sapiens_hsa005651.55676236
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.54683722
23Butanoate metabolism_Homo sapiens_hsa006501.54417221
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46701746
25Morphine addiction_Homo sapiens_hsa050321.40235709
26Primary immunodeficiency_Homo sapiens_hsa053401.32662950
27Oxidative phosphorylation_Homo sapiens_hsa001901.32232545
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31803079
29Measles_Homo sapiens_hsa051621.26707252
30Collecting duct acid secretion_Homo sapiens_hsa049661.20535419
31Arachidonic acid metabolism_Homo sapiens_hsa005901.20203515
32Glycerolipid metabolism_Homo sapiens_hsa005611.13507260
33Regulation of autophagy_Homo sapiens_hsa041401.10609733
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07315315
35Nicotine addiction_Homo sapiens_hsa050330.98948303
36Glycerophospholipid metabolism_Homo sapiens_hsa005640.98756316
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98037480
38Taste transduction_Homo sapiens_hsa047420.96665078
39Caffeine metabolism_Homo sapiens_hsa002320.94726059
40Rheumatoid arthritis_Homo sapiens_hsa053230.94302324
41Parkinsons disease_Homo sapiens_hsa050120.92494951
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91777165
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91183647
44Tryptophan metabolism_Homo sapiens_hsa003800.90662740
45Fatty acid biosynthesis_Homo sapiens_hsa000610.89232706
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87927525
47ABC transporters_Homo sapiens_hsa020100.85469131
48Circadian entrainment_Homo sapiens_hsa047130.84198193
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83117251
50Ovarian steroidogenesis_Homo sapiens_hsa049130.81030494
51Tuberculosis_Homo sapiens_hsa051520.80460439
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76576413
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75866428
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.75830266
55Leishmaniasis_Homo sapiens_hsa051400.72643685
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72544093
57Shigellosis_Homo sapiens_hsa051310.70658613
58Selenocompound metabolism_Homo sapiens_hsa004500.64928142
59Glutamatergic synapse_Homo sapiens_hsa047240.63869165
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.63672736
61Chemical carcinogenesis_Homo sapiens_hsa052040.63422326
62RNA polymerase_Homo sapiens_hsa030200.60424820
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58908300
64Nitrogen metabolism_Homo sapiens_hsa009100.58805002
65Histidine metabolism_Homo sapiens_hsa003400.58725078
66GABAergic synapse_Homo sapiens_hsa047270.58592453
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58241506
68Peroxisome_Homo sapiens_hsa041460.57429182
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57074455
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56226601
71Osteoclast differentiation_Homo sapiens_hsa043800.55468420
72Homologous recombination_Homo sapiens_hsa034400.52302297
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52256576
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.51750549
75B cell receptor signaling pathway_Homo sapiens_hsa046620.50009754
76Insulin secretion_Homo sapiens_hsa049110.49831424
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48687091
78VEGF signaling pathway_Homo sapiens_hsa043700.48459430
79Alzheimers disease_Homo sapiens_hsa050100.47999874
80Calcium signaling pathway_Homo sapiens_hsa040200.46860585
81Fat digestion and absorption_Homo sapiens_hsa049750.45423126
82Basal transcription factors_Homo sapiens_hsa030220.44307587
83Retinol metabolism_Homo sapiens_hsa008300.43696401
84Cholinergic synapse_Homo sapiens_hsa047250.43527079
85Prolactin signaling pathway_Homo sapiens_hsa049170.42892505
86Ribosome_Homo sapiens_hsa030100.42282379
87Oxytocin signaling pathway_Homo sapiens_hsa049210.41291932
88Huntingtons disease_Homo sapiens_hsa050160.41132388
89Propanoate metabolism_Homo sapiens_hsa006400.41093789
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38516781
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38345826
92Chemokine signaling pathway_Homo sapiens_hsa040620.38307913
93Platelet activation_Homo sapiens_hsa046110.37829957
94Viral myocarditis_Homo sapiens_hsa054160.36899629
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36761566
96Serotonergic synapse_Homo sapiens_hsa047260.36176540
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35254051
98mTOR signaling pathway_Homo sapiens_hsa041500.31593497
99Apoptosis_Homo sapiens_hsa042100.28803663
100Dorso-ventral axis formation_Homo sapiens_hsa043200.26530831
101African trypanosomiasis_Homo sapiens_hsa051430.26359163
102Chronic myeloid leukemia_Homo sapiens_hsa052200.24196931
103MAPK signaling pathway_Homo sapiens_hsa040100.24118183
104Toxoplasmosis_Homo sapiens_hsa051450.23681065
105Acute myeloid leukemia_Homo sapiens_hsa052210.23301466
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22054344
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21845499
108Salmonella infection_Homo sapiens_hsa051320.21534804
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21077626
110Legionellosis_Homo sapiens_hsa051340.20789282
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20611949
112Long-term potentiation_Homo sapiens_hsa047200.20222538
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.19888073
114Rap1 signaling pathway_Homo sapiens_hsa040150.19400291
115p53 signaling pathway_Homo sapiens_hsa041150.19143703
116TNF signaling pathway_Homo sapiens_hsa046680.18726788
117Mismatch repair_Homo sapiens_hsa034300.17914605
118HIF-1 signaling pathway_Homo sapiens_hsa040660.16378406
119Base excision repair_Homo sapiens_hsa034100.15499736
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14955121
121Gap junction_Homo sapiens_hsa045400.14869066
122Biosynthesis of amino acids_Homo sapiens_hsa012300.14634959
123Focal adhesion_Homo sapiens_hsa045100.13998112
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13342797
125Proteoglycans in cancer_Homo sapiens_hsa052050.13274171
126Renal cell carcinoma_Homo sapiens_hsa052110.12779823
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.11452641
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11392514
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11361964
130Hepatitis B_Homo sapiens_hsa051610.10940814
131Endocytosis_Homo sapiens_hsa041440.10911449
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.10885776
133ErbB signaling pathway_Homo sapiens_hsa040120.10750694
134Hedgehog signaling pathway_Homo sapiens_hsa043400.10466469
135Arginine and proline metabolism_Homo sapiens_hsa003300.10427821
136Bladder cancer_Homo sapiens_hsa052190.10153382
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09807888
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09396301
139MicroRNAs in cancer_Homo sapiens_hsa052060.09211779
140Notch signaling pathway_Homo sapiens_hsa043300.09137279
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08983074
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08823759
143FoxO signaling pathway_Homo sapiens_hsa040680.08361026
144Long-term depression_Homo sapiens_hsa047300.08287857
145Estrogen signaling pathway_Homo sapiens_hsa049150.08164292
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.08140838
147Hippo signaling pathway_Homo sapiens_hsa043900.07798676
148Olfactory transduction_Homo sapiens_hsa047400.07482562
149Insulin signaling pathway_Homo sapiens_hsa049100.07358913
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07217019
151GnRH signaling pathway_Homo sapiens_hsa049120.06651223
152Influenza A_Homo sapiens_hsa051640.06614261
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.06471506
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04607728
155ECM-receptor interaction_Homo sapiens_hsa045120.04492413
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.04039977
157Malaria_Homo sapiens_hsa051440.03377582
158Pancreatic cancer_Homo sapiens_hsa052120.03216320
159Amoebiasis_Homo sapiens_hsa051460.02907631
160Viral carcinogenesis_Homo sapiens_hsa052030.02869471
161Phagosome_Homo sapiens_hsa041450.02699719
162Salivary secretion_Homo sapiens_hsa049700.02608973
163Colorectal cancer_Homo sapiens_hsa052100.02187578
164NF-kappa B signaling pathway_Homo sapiens_hsa040640.02161037

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