NMUR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1imidazole-containing compound metabolic process (GO:0052803)6.23085382
2ventricular system development (GO:0021591)5.43006154
3lung secretory cell differentiation (GO:0061140)5.39514977
4cilium movement (GO:0003341)4.92891959
5regulation of mitochondrial translation (GO:0070129)4.85612130
6prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.54638460
7neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.54615338
8neurotransmitter catabolic process (GO:0042135)4.51234648
9flavonoid metabolic process (GO:0009812)4.35330713
10lung lobe morphogenesis (GO:0060463)4.25769622
11artery development (GO:0060840)4.24570828
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17874938
13cell-cell junction maintenance (GO:0045217)4.04714726
14neuronal stem cell maintenance (GO:0097150)3.82494626
15lung vasculature development (GO:0060426)3.81332701
16exocrine pancreas development (GO:0031017)3.79451298
17ubiquinone biosynthetic process (GO:0006744)3.78544577
18outer ear morphogenesis (GO:0042473)3.78238933
19negative regulation of transcription by competitive promoter binding (GO:0010944)3.78138660
20base-excision repair, AP site formation (GO:0006285)3.77187297
21long-term memory (GO:0007616)3.72191958
22left/right axis specification (GO:0070986)3.68840110
23regulation of glutamate receptor signaling pathway (GO:1900449)3.65591426
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64322457
25prostate gland growth (GO:0060736)3.60631036
26adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.59109082
27auditory behavior (GO:0031223)3.56666862
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56257214
29locomotory exploration behavior (GO:0035641)3.53575494
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.53114224
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.51128246
32one-carbon compound transport (GO:0019755)3.50798621
33regulation of cholesterol biosynthetic process (GO:0045540)3.49021776
34respiratory tube development (GO:0030323)3.48178206
35layer formation in cerebral cortex (GO:0021819)3.47222060
36neuron recognition (GO:0008038)3.46400585
37striatum development (GO:0021756)3.46195092
38behavioral response to nicotine (GO:0035095)3.41479203
39purine deoxyribonucleotide catabolic process (GO:0009155)3.40516684
40regulation of synapse structural plasticity (GO:0051823)3.40472473
41signal transduction involved in regulation of gene expression (GO:0023019)3.37724525
42cranial nerve structural organization (GO:0021604)3.36580574
43facial nerve structural organization (GO:0021612)3.36574663
44cell junction maintenance (GO:0034331)3.35303964
45negative regulation of amino acid transport (GO:0051956)3.34701223
46response to auditory stimulus (GO:0010996)3.34527414
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.34010284
48proline transport (GO:0015824)3.33848181
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33133473
50positive regulation of triglyceride biosynthetic process (GO:0010867)3.31495332
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30779587
52L-fucose catabolic process (GO:0042355)3.29946175
53fucose catabolic process (GO:0019317)3.29946175
54L-fucose metabolic process (GO:0042354)3.29946175
55ubiquinone metabolic process (GO:0006743)3.28565675
56regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27049451
57biotin metabolic process (GO:0006768)3.24593687
58negative regulation of digestive system process (GO:0060457)3.23707003
59regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.21575386
60regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.21575386
61quinone biosynthetic process (GO:1901663)3.21333931
62neurotransmitter secretion (GO:0007269)3.21300058
63regulation of proton transport (GO:0010155)3.20312008
64regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.20238872
65positive regulation of neurological system process (GO:0031646)3.19176453
66glycerophospholipid catabolic process (GO:0046475)3.18662876
67neuromuscular process controlling posture (GO:0050884)3.17596166
68neurotransmitter transport (GO:0006836)3.15554021
69positive regulation of glycogen metabolic process (GO:0070875)3.12895630
70regulation of appetite (GO:0032098)3.11377867
71regulation of synaptic vesicle exocytosis (GO:2000300)3.11282893
72lung epithelial cell differentiation (GO:0060487)3.10975113
73axoneme assembly (GO:0035082)3.09238757
74ATP synthesis coupled proton transport (GO:0015986)3.08502057
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08502057
76oxygen transport (GO:0015671)3.08442882
77central nervous system myelination (GO:0022010)3.07189964
78axon ensheathment in central nervous system (GO:0032291)3.07189964
79mating behavior (GO:0007617)3.06382011
80dendritic spine morphogenesis (GO:0060997)3.05239755
81regulation of synaptic vesicle transport (GO:1902803)3.04067624
82response to histamine (GO:0034776)3.03987917
83axonal fasciculation (GO:0007413)3.02704981
84natural killer cell mediated immunity (GO:0002228)3.02340468
85natural killer cell mediated cytotoxicity (GO:0042267)3.02340468
86epithelial cilium movement (GO:0003351)3.01342659
87protein import into peroxisome matrix (GO:0016558)3.01056249
88alkaloid metabolic process (GO:0009820)3.00552697
89auditory receptor cell stereocilium organization (GO:0060088)2.99404487
90eosinophil migration (GO:0072677)2.97764359
91negative regulation of T cell differentiation in thymus (GO:0033085)2.97530136
92diaphragm development (GO:0060539)2.97089455
93neuron cell-cell adhesion (GO:0007158)2.97043142
94positive regulation of potassium ion transmembrane transport (GO:1901381)2.96629407
95synaptic vesicle maturation (GO:0016188)2.95968615
96vocalization behavior (GO:0071625)2.95693781
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95047514
98dopamine biosynthetic process (GO:0042416)2.94404335
99sulfate transmembrane transport (GO:1902358)2.93623701
100positive regulation of amine transport (GO:0051954)2.90523354
101negative regulation of appetite (GO:0032099)2.89731842
102negative regulation of response to food (GO:0032096)2.89731842
103platelet dense granule organization (GO:0060155)2.89287450
104nephron epithelium morphogenesis (GO:0072088)2.88955323
105nephron tubule morphogenesis (GO:0072078)2.88955323
106dentate gyrus development (GO:0021542)2.86892093
107positive regulation of muscle hypertrophy (GO:0014742)2.86711329
108positive regulation of cardiac muscle hypertrophy (GO:0010613)2.86711329
109synaptic vesicle exocytosis (GO:0016079)2.86603938
110regulation of glutamate secretion (GO:0014048)2.85328329
111negative regulation of epidermal cell differentiation (GO:0045605)2.84474251
112behavioral fear response (GO:0001662)2.83636914
113behavioral defense response (GO:0002209)2.83636914
114synaptic transmission, dopaminergic (GO:0001963)2.83133021
115protein complex biogenesis (GO:0070271)2.82624956
116mitotic nuclear envelope reassembly (GO:0007084)2.81833460
117nuclear envelope reassembly (GO:0031468)2.81833460
118seminiferous tubule development (GO:0072520)2.81063170
119ribosomal small subunit assembly (GO:0000028)2.80878711
120regulation of bile acid biosynthetic process (GO:0070857)2.80461577
121positive regulation of histone deacetylation (GO:0031065)2.79921491
122cell migration involved in gastrulation (GO:0042074)2.79508141
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79437885
124regulation of establishment or maintenance of cell polarity (GO:0032878)2.79275232
125membrane hyperpolarization (GO:0060081)2.79053159
126positive regulation of protein autophosphorylation (GO:0031954)2.78836564
127synaptic transmission, cholinergic (GO:0007271)2.76646540
128mechanosensory behavior (GO:0007638)2.76034334
129amino acid salvage (GO:0043102)2.75282537
130L-methionine salvage (GO:0071267)2.75282537
131L-methionine biosynthetic process (GO:0071265)2.75282537
132positive regulation of glycogen biosynthetic process (GO:0045725)2.74752096
133morphogenesis of an epithelial fold (GO:0060571)2.74149660
134activation of protein kinase A activity (GO:0034199)2.73201278
135substrate-independent telencephalic tangential migration (GO:0021826)2.72939185
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72939185
137striated muscle atrophy (GO:0014891)2.72913248
138viral transcription (GO:0019083)2.72836929
139cerebellar Purkinje cell layer development (GO:0021680)2.71347330
140lung cell differentiation (GO:0060479)2.70785172
141translational termination (GO:0006415)2.70735040
142transmission of nerve impulse (GO:0019226)2.70718848
143protein localization to cilium (GO:0061512)2.70574513
144exploration behavior (GO:0035640)2.70454577
145glyoxylate metabolic process (GO:0046487)2.69819827
146regulation of neurotransmitter levels (GO:0001505)2.68674008
147ionotropic glutamate receptor signaling pathway (GO:0035235)2.68599292
148asymmetric protein localization (GO:0008105)2.68512633
149negative regulation of epidermis development (GO:0045683)2.67996878
150branching involved in prostate gland morphogenesis (GO:0060442)2.67840812
151renal tubule morphogenesis (GO:0061333)2.67219978
152neuronal action potential propagation (GO:0019227)2.66089807
153neuronal action potential (GO:0019228)2.66051197
154protein localization to synapse (GO:0035418)2.65854954
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65691954
156kidney morphogenesis (GO:0060993)2.65259208
157regulation of neuronal synaptic plasticity (GO:0048168)2.64424253
158sequestering of actin monomers (GO:0042989)2.64344204
159positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63028481
160neuronal ion channel clustering (GO:0045161)2.62370883
161activated T cell proliferation (GO:0050798)2.61816051
162cilium or flagellum-dependent cell motility (GO:0001539)2.61121396
163regulation of glucocorticoid secretion (GO:2000849)2.60931741
164regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60407313
165regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.59529888
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.59392888
167fear response (GO:0042596)2.58968342
168response to prostaglandin E (GO:0034695)2.58833845
169succinate metabolic process (GO:0006105)2.58520407
170cytochrome complex assembly (GO:0017004)2.58451069
171amine catabolic process (GO:0009310)2.57999891
172cellular biogenic amine catabolic process (GO:0042402)2.57999891
173gamma-aminobutyric acid transport (GO:0015812)2.57350629
174positive regulation of fatty acid beta-oxidation (GO:0032000)2.55580372
175neurotransmitter biosynthetic process (GO:0042136)2.54705468
176regulation of smooth muscle cell apoptotic process (GO:0034391)2.54681764
177respiratory system process (GO:0003016)2.54591449
178positive regulation of synapse assembly (GO:0051965)2.54061587
179metanephric epithelium development (GO:0072207)2.53625772
180drug transmembrane transport (GO:0006855)2.53438866
181presynaptic membrane organization (GO:0097090)2.52934045
182kynurenine metabolic process (GO:0070189)2.52854764
183regulation of transmission of nerve impulse (GO:0051969)2.52830141
184cellular potassium ion homeostasis (GO:0030007)2.51061383
185negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50163634
186glutamate receptor signaling pathway (GO:0007215)2.49345846
187lung epithelium development (GO:0060428)2.49175774
188regulation of protein kinase A signaling (GO:0010738)2.48656811
189calcium-mediated signaling using intracellular calcium source (GO:0035584)2.48391685
190positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47087684
191cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46925048
192positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46209433
193potassium ion homeostasis (GO:0055075)2.43518425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17755543
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.37343938
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.94576125
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.64416716
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07279543
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75404652
7VDR_22108803_ChIP-Seq_LS180_Human2.74083599
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70359675
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68607352
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68588478
11TAF15_26573619_Chip-Seq_HEK293_Human2.56567297
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55116171
13GBX2_23144817_ChIP-Seq_PC3_Human2.48591206
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.47560689
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39248941
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32423883
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30032352
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29272655
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27088207
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23637134
21AR_21572438_ChIP-Seq_LNCaP_Human2.18643799
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16447030
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16447030
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.16167690
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.14857080
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11476213
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.11062794
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08254453
29IGF1R_20145208_ChIP-Seq_DFB_Human2.07739340
30ZNF263_19887448_ChIP-Seq_K562_Human2.03279202
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99411221
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.98940073
33DROSHA_22980978_ChIP-Seq_HELA_Human1.91073433
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90584826
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.90393183
36IRF1_19129219_ChIP-ChIP_H3396_Human1.86214041
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75476843
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64594010
39* P300_19829295_ChIP-Seq_ESCs_Human1.62789096
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.60605005
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59720300
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59609135
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59268923
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57109754
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.55915063
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54843047
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.51297511
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50913555
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.50850757
50FUS_26573619_Chip-Seq_HEK293_Human1.50098459
51* REST_18959480_ChIP-ChIP_MESCs_Mouse1.49572842
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49437474
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48858360
54TP53_22573176_ChIP-Seq_HFKS_Human1.48624519
55ZNF274_21170338_ChIP-Seq_K562_Hela1.47849574
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.47100318
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46508699
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45244439
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43863627
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43863627
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43863627
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43440769
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.42996299
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41555409
65P68_20966046_ChIP-Seq_HELA_Human1.41418493
66BCAT_22108803_ChIP-Seq_LS180_Human1.39008000
67ER_23166858_ChIP-Seq_MCF-7_Human1.37546873
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37539610
69* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36048630
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35079412
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.34995809
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33988368
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.31487408
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27483531
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26939367
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25304246
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25233696
78RNF2_27304074_Chip-Seq_NSC_Mouse1.25099597
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23372333
80CBP_20019798_ChIP-Seq_JUKART_Human1.23372333
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23327976
82EGR1_19032775_ChIP-ChIP_M12_Human1.22938928
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.22098489
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21876435
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21172991
86FOXH1_21741376_ChIP-Seq_ESCs_Human1.20692467
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20495904
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.20495904
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20465906
90RUNX2_22187159_ChIP-Seq_PCA_Human1.20398152
91KLF4_19829295_ChIP-Seq_ESCs_Human1.20164803
92AR_25329375_ChIP-Seq_VCAP_Human1.18889412
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.17444575
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17224860
95OCT4_19829295_ChIP-Seq_ESCs_Human1.16441899
96KLF5_25053715_ChIP-Seq_YYC3_Human1.12468486
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12279919
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11932363
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10217339
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10176540
101CEBPB_22108803_ChIP-Seq_LS180_Human1.10124345
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.09907904
103HTT_18923047_ChIP-ChIP_STHdh_Human1.09687032
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09512449
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09455184
106* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09247286
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08757568
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.08549313
109RXR_22108803_ChIP-Seq_LS180_Human1.08253443
110ERA_21632823_ChIP-Seq_H3396_Human1.07618730
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05844144
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04972460
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04201297
114AHR_22903824_ChIP-Seq_MCF-7_Human1.03980420
115SA1_27219007_Chip-Seq_Bcells_Human1.03569305
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.03252345
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.03059155
118STAT3_23295773_ChIP-Seq_U87_Human1.03011843
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.01747111
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.01683698
121NANOG_20526341_ChIP-Seq_ESCs_Human1.01369363
122CTCF_20526341_ChIP-Seq_ESCs_Human1.01164352
123* SOX2_20726797_ChIP-Seq_SW620_Human1.00750499
124MYC_19829295_ChIP-Seq_ESCs_Human1.00236069
125TCF4_22108803_ChIP-Seq_LS180_Human0.99879639
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99836091
127AR_19668381_ChIP-Seq_PC3_Human0.99748068
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99047414
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98499373
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98118220
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97655933
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97632634
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97616351
134* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94276745
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93764762
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93245800
137TAF2_19829295_ChIP-Seq_ESCs_Human0.92731006
138CTCF_27219007_Chip-Seq_Bcells_Human0.92581639
139TP63_22573176_ChIP-Seq_HFKS_Human0.91673821
140* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91614783
141* SMAD4_21741376_ChIP-Seq_EPCs_Human0.89536397
142JUN_21703547_ChIP-Seq_K562_Human0.88899617
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88717816
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88012358
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87970177
146* TCF4_23295773_ChIP-Seq_U87_Human0.87830102
147TP53_22127205_ChIP-Seq_IMR90_Human0.87531451
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86504204
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.86253847
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85474095
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85327945
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.84948985
153PHF8_20622854_ChIP-Seq_HELA_Human0.84199972
154TP53_18474530_ChIP-ChIP_U2OS_Human0.83764094
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.83346047
156KDM5A_27292631_Chip-Seq_BREAST_Human0.83152344
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83066319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.83489308
2MP0003122_maternal_imprinting3.87628012
3MP0001968_abnormal_touch/_nociception3.77796742
4MP0005645_abnormal_hypothalamus_physiol3.62447382
5MP0004859_abnormal_synaptic_plasticity3.42052871
6MP0002822_catalepsy3.27059498
7MP0003283_abnormal_digestive_organ3.13900165
8MP0003938_abnormal_ear_development3.05375848
9MP0002876_abnormal_thyroid_physiology2.82364323
10MP0002736_abnormal_nociception_after2.78991833
11MP0008004_abnormal_stomach_pH2.77906422
12MP0005646_abnormal_pituitary_gland2.75324119
13MP0009046_muscle_twitch2.69151368
14MP0003635_abnormal_synaptic_transmissio2.68393605
15MP0003880_abnormal_central_pattern2.62049475
16MP0009745_abnormal_behavioral_response2.61758458
17MP0002064_seizures2.58853197
18MP0001348_abnormal_lacrimal_gland2.56719206
19MP0006276_abnormal_autonomic_nervous2.55062018
20MP0001501_abnormal_sleep_pattern2.52561820
21MP0003119_abnormal_digestive_system2.49036779
22MP0009379_abnormal_foot_pigmentation2.46578174
23MP0000678_abnormal_parathyroid_gland2.41253181
24MP0006292_abnormal_olfactory_placode2.33736769
25MP0005394_taste/olfaction_phenotype2.31240738
26MP0005499_abnormal_olfactory_system2.31240738
27* MP0001440_abnormal_grooming_behavior2.24564335
28MP0004270_analgesia2.22565139
29MP0002734_abnormal_mechanical_nocicepti2.20810073
30MP0003787_abnormal_imprinting2.19321096
31MP0002272_abnormal_nervous_system2.16818676
32MP0001486_abnormal_startle_reflex2.13124528
33MP0002063_abnormal_learning/memory/cond2.09268280
34MP0005451_abnormal_body_composition2.05927148
35* MP0002735_abnormal_chemical_nociception2.04046845
36MP0002572_abnormal_emotion/affect_behav2.03201208
37MP0001529_abnormal_vocalization1.99257430
38MP0005386_behavior/neurological_phenoty1.95648080
39MP0004924_abnormal_behavior1.95648080
40MP0004133_heterotaxia1.93655314
41MP0002557_abnormal_social/conspecific_i1.84814101
42MP0002653_abnormal_ependyma_morphology1.77707495
43MP0000462_abnormal_digestive_system1.77393889
44MP0003123_paternal_imprinting1.74888066
45MP0001346_abnormal_lacrimal_gland1.71100502
46MP0005083_abnormal_biliary_tract1.64979934
47MP0000049_abnormal_middle_ear1.55785172
48* MP0001970_abnormal_pain_threshold1.55421739
49MP0002638_abnormal_pupillary_reflex1.52149055
50MP0003690_abnormal_glial_cell1.51705920
51MP0005423_abnormal_somatic_nervous1.51085313
52MP0002249_abnormal_larynx_morphology1.47418551
53* MP0002733_abnormal_thermal_nociception1.46188352
54MP0005623_abnormal_meninges_morphology1.45088804
55MP0000470_abnormal_stomach_morphology1.43388311
56MP0002067_abnormal_sensory_capabilities1.42250228
57MP0003121_genomic_imprinting1.41043934
58MP0002909_abnormal_adrenal_gland1.40547988
59MP0008789_abnormal_olfactory_epithelium1.40511979
60MP0000026_abnormal_inner_ear1.33122807
61MP0000372_irregular_coat_pigmentation1.32212920
62MP0001188_hyperpigmentation1.28225283
63MP0004043_abnormal_pH_regulation1.28127252
64MP0008877_abnormal_DNA_methylation1.28111170
65MP0008872_abnormal_physiological_respon1.27263044
66MP0004742_abnormal_vestibular_system1.26327842
67MP0003942_abnormal_urinary_system1.25034585
68MP0010386_abnormal_urinary_bladder1.24507850
69MP0000467_abnormal_esophagus_morphology1.24083723
70MP0000778_abnormal_nervous_system1.23471355
71MP0005409_darkened_coat_color1.21784114
72MP0002234_abnormal_pharynx_morphology1.18717447
73MP0005085_abnormal_gallbladder_physiolo1.17003883
74MP0005360_urolithiasis1.16552577
75MP0001905_abnormal_dopamine_level1.16503687
76MP0000003_abnormal_adipose_tissue1.14436656
77MP0004142_abnormal_muscle_tone1.13903013
78MP0008569_lethality_at_weaning1.13673891
79MP0006072_abnormal_retinal_apoptosis1.12051642
80* MP0003959_abnormal_lean_body1.11302856
81MP0001984_abnormal_olfaction1.10989542
82MP0001502_abnormal_circadian_rhythm1.08429289
83MP0001177_atelectasis1.08187951
84MP0005408_hypopigmentation1.07358405
85MP0008874_decreased_physiological_sensi1.06209509
86MP0008058_abnormal_DNA_repair1.05262819
87MP0002184_abnormal_innervation1.04220663
88MP0005551_abnormal_eye_electrophysiolog1.03338770
89MP0001664_abnormal_digestion1.03015343
90MP0003879_abnormal_hair_cell1.02740782
91MP0001542_abnormal_bone_strength1.01848097
92MP0002066_abnormal_motor_capabilities/c1.01511894
93MP0002108_abnormal_muscle_morphology1.00507611
94MP0005535_abnormal_body_temperature0.98598224
95MP0002882_abnormal_neuron_morphology0.97195284
96MP0002837_dystrophic_cardiac_calcinosis0.96862591
97MP0004134_abnormal_chest_morphology0.96662081
98MP0000751_myopathy0.95728362
99MP0004811_abnormal_neuron_physiology0.95718486
100MP0000920_abnormal_myelination0.95576767
101MP0004130_abnormal_muscle_cell0.95313055
102MP0009780_abnormal_chondrocyte_physiolo0.93094663
103* MP0005448_abnormal_energy_balance0.91136780
104MP0002160_abnormal_reproductive_system0.90271529
105MP0002233_abnormal_nose_morphology0.88549091
106MP0002254_reproductive_system_inflammat0.88514278
107MP0000762_abnormal_tongue_morphology0.88324026
108MP0004147_increased_porphyrin_level0.86151687
109* MP0002069_abnormal_eating/drinking_beha0.85994903
110MP0003045_fibrosis0.84882718
111MP0003329_amyloid_beta_deposits0.84573357
112MP0001485_abnormal_pinna_reflex0.84543950
113MP0001765_abnormal_ion_homeostasis0.84452554
114MP0000681_abnormal_thyroid_gland0.83570398
115MP0000427_abnormal_hair_cycle0.83503559
116MP0000538_abnormal_urinary_bladder0.83487715
117MP0002752_abnormal_somatic_nervous0.83056498
118MP0001286_abnormal_eye_development0.82839320
119MP0003115_abnormal_respiratory_system0.82269844
120MP0002928_abnormal_bile_duct0.82237594
121MP0003646_muscle_fatigue0.82223160
122MP0002163_abnormal_gland_morphology0.82089559
123MP0002277_abnormal_respiratory_mucosa0.81091873
124MP0003385_abnormal_body_wall0.80719247
125MP0001963_abnormal_hearing_physiology0.79741012
126MP0003943_abnormal_hepatobiliary_system0.78404034
127MP0005084_abnormal_gallbladder_morpholo0.77345664
128* MP0002078_abnormal_glucose_homeostasis0.77137712
129MP0004085_abnormal_heartbeat0.77123599
130MP0009703_decreased_birth_body0.77033478
131MP0000955_abnormal_spinal_cord0.76396677
132MP0002693_abnormal_pancreas_physiology0.75478180
133MP0002090_abnormal_vision0.75115708
134MP0000428_abnormal_craniofacial_morphol0.74238373
135MP0000631_abnormal_neuroendocrine_gland0.73828374
136MP0009697_abnormal_copulation0.73240359
137MP0004885_abnormal_endolymph0.71573218
138MP0002210_abnormal_sex_determination0.70877906
139MP0004019_abnormal_vitamin_homeostasis0.70205980
140MP0003868_abnormal_feces_composition0.70185715
141MP0002932_abnormal_joint_morphology0.70130319
142MP0003755_abnormal_palate_morphology0.69557744
143MP0002152_abnormal_brain_morphology0.69301252
144MP0005334_abnormal_fat_pad0.69053619
145* MP0003638_abnormal_response/metabolism_0.69009773
146MP0004197_abnormal_fetal_growth/weight/0.68962599
147MP0005310_abnormal_salivary_gland0.68791455
148MP0001849_ear_inflammation0.68507801
149MP0002229_neurodegeneration0.68454169
150MP0008875_abnormal_xenobiotic_pharmacok0.67165638
151MP0005253_abnormal_eye_physiology0.67048862
152MP0003252_abnormal_bile_duct0.66310120
153MP0000639_abnormal_adrenal_gland0.64724664
154MP0002971_abnormal_brown_adipose0.63559911
155MP0003634_abnormal_glial_cell0.62986238
156MP0005381_digestive/alimentary_phenotyp0.61933685

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.39288990
2Focal motor seizures (HP:0011153)6.23615025
3Abnormal respiratory motile cilium physiology (HP:0012261)5.13764397
4Absence seizures (HP:0002121)4.79934870
5Focal seizures (HP:0007359)4.78191784
6Short nail (HP:0001799)4.65102146
711 pairs of ribs (HP:0000878)4.64435954
8Radial bowing (HP:0002986)4.49189278
9Atonic seizures (HP:0010819)4.33458118
10Visual hallucinations (HP:0002367)4.29653353
11Abnormal ciliary motility (HP:0012262)4.18785082
12Rhinitis (HP:0012384)4.17817974
13Myokymia (HP:0002411)4.17022139
14Dialeptic seizures (HP:0011146)3.89311220
15Generalized tonic-clonic seizures (HP:0002069)3.75671661
16Pendular nystagmus (HP:0012043)3.72384723
17Chronic bronchitis (HP:0004469)3.66071965
18Cupped ribs (HP:0000887)3.66023042
19Mesangial abnormality (HP:0001966)3.65412492
20Birth length less than 3rd percentile (HP:0003561)3.63947553
21Broad distal phalanx of finger (HP:0009836)3.62919792
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.50040304
23Absent/shortened dynein arms (HP:0200106)3.50040304
24Limb dystonia (HP:0002451)3.45932314
25Hypoplastic ischia (HP:0003175)3.38074822
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33065263
27Breast hypoplasia (HP:0003187)3.23094202
28Abnormality of cochlea (HP:0000375)3.16238061
29Psychosis (HP:0000709)3.11751838
30Clumsiness (HP:0002312)3.08809957
31Bowing of the arm (HP:0006488)3.04281068
32Bowed forearm bones (HP:0003956)3.04281068
33Fragile skin (HP:0001030)3.00328461
34Irregular vertebral endplates (HP:0003301)2.97993997
35Hypoglycemic seizures (HP:0002173)2.89364304
36Chin dimple (HP:0010751)2.88233798
37Febrile seizures (HP:0002373)2.85431738
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.82571385
39Cerebellar dysplasia (HP:0007033)2.81451632
40Hypothermia (HP:0002045)2.77262698
41Hyperthyroidism (HP:0000836)2.76928215
42Squamous cell carcinoma (HP:0002860)2.76632784
43Esophageal atresia (HP:0002032)2.75013539
44Spinal cord compression (HP:0002176)2.73859861
45Abnormality of the ischium (HP:0003174)2.71405746
46Abnormality of the pubic bones (HP:0003172)2.67378327
47Abnormal pancreas size (HP:0012094)2.66250606
48Thyroid-stimulating hormone excess (HP:0002925)2.65381305
49Aplastic anemia (HP:0001915)2.64409386
50Amelogenesis imperfecta (HP:0000705)2.63573028
51Short femoral neck (HP:0100864)2.62927604
52Tubular atrophy (HP:0000092)2.62520622
53Cystic liver disease (HP:0006706)2.62209068
54Confusion (HP:0001289)2.61917144
55Narrow nasal bridge (HP:0000446)2.61215802
56Abnormal pupillary function (HP:0007686)2.60330633
57Hypoplasia of the uterus (HP:0000013)2.57555745
58Papilledema (HP:0001085)2.53907599
59Hyperventilation (HP:0002883)2.50536480
60Chronic hepatic failure (HP:0100626)2.50033920
61Prominent metopic ridge (HP:0005487)2.49354068
62Bicuspid aortic valve (HP:0001647)2.47108950
63Anxiety (HP:0000739)2.47017362
64Abnormal number of erythroid precursors (HP:0012131)2.46983472
65Morphological abnormality of the inner ear (HP:0011390)2.46648124
66Patent foramen ovale (HP:0001655)2.46079986
67Azoospermia (HP:0000027)2.44714760
68Oral leukoplakia (HP:0002745)2.42214116
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.42011468
70Supranuclear gaze palsy (HP:0000605)2.40844632
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40668686
72Poikiloderma (HP:0001029)2.39731214
73Type II lissencephaly (HP:0007260)2.35635563
74Focal segmental glomerulosclerosis (HP:0000097)2.35632301
75Abnormality of the metopic suture (HP:0005556)2.33950582
76Pheochromocytoma (HP:0002666)2.33472515
77Abnormal drinking behavior (HP:0030082)2.32975673
78Polydipsia (HP:0001959)2.32975673
79Abnormality of cells of the erythroid lineage (HP:0012130)2.31963475
80Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.29886006
81Symptomatic seizures (HP:0011145)2.27120289
82Progressive inability to walk (HP:0002505)2.26955894
83Abnormality of the vertebral endplates (HP:0005106)2.22605106
84Anterior segment dysgenesis (HP:0007700)2.22361718
85Neuroendocrine neoplasm (HP:0100634)2.19144537
86Fibular hypoplasia (HP:0003038)2.19026894
87Severe muscular hypotonia (HP:0006829)2.18077201
88Spondylolisthesis (HP:0003302)2.17607910
89Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.15809776
90Abnormal respiratory epithelium morphology (HP:0012253)2.12603694
91Abnormal respiratory motile cilium morphology (HP:0005938)2.12603694
92Gait imbalance (HP:0002141)2.12208281
93Pancreatic cysts (HP:0001737)2.10705620
94Agitation (HP:0000713)2.10175395
95Hyperglycinuria (HP:0003108)2.09446316
96Overfolded helix (HP:0000396)2.09096527
97Exotropia (HP:0000577)2.08690017
98Aplasia/hypoplasia of the uterus (HP:0008684)2.08480787
99Abnormality of carpal bone ossification (HP:0006257)2.07671883
100Progressive cerebellar ataxia (HP:0002073)2.07140689
101Prolonged QT interval (HP:0001657)2.06692402
102Fragile nails (HP:0001808)2.06488418
103Anosmia (HP:0000458)2.03949538
104Abnormality of DNA repair (HP:0003254)2.03620918
105Delayed gross motor development (HP:0002194)2.03521140
106Menstrual irregularities (HP:0000858)2.03021385
107Abnormal EKG (HP:0003115)2.03001636
108Abnormal eating behavior (HP:0100738)2.02333072
109Medial flaring of the eyebrow (HP:0010747)2.01976431
110Maternal diabetes (HP:0009800)2.01963104
111Sparse scalp hair (HP:0002209)2.00959375
112Postaxial foot polydactyly (HP:0001830)1.98478529
113Double outlet right ventricle (HP:0001719)1.96845136
114Congenital malformation of the right heart (HP:0011723)1.96845136
115Epileptic encephalopathy (HP:0200134)1.95862778
116Abnormality of serine family amino acid metabolism (HP:0010894)1.95826139
117Abnormality of glycine metabolism (HP:0010895)1.95826139
118Abnormal spermatogenesis (HP:0008669)1.94819967
119Scanning speech (HP:0002168)1.94471995
120Pancreatic fibrosis (HP:0100732)1.94273993
121Prolonged neonatal jaundice (HP:0006579)1.91674711
122Abnormal biliary tract physiology (HP:0012439)1.91645644
123Bile duct proliferation (HP:0001408)1.91645644
124Hypercortisolism (HP:0001578)1.91329073
125Truncal ataxia (HP:0002078)1.91283341
126Polar cataract (HP:0010696)1.91156849
127Specific learning disability (HP:0001328)1.90516415
128Abnormally folded helix (HP:0008544)1.90312653
129Cerebral aneurysm (HP:0004944)1.89543723
130Aplasia/hypoplasia of the femur (HP:0005613)1.88029384
131Reticulocytosis (HP:0001923)1.87832750
132Gout (HP:0001997)1.87650300
133Anomalous pulmonary venous return (HP:0010772)1.87290951
134Type 2 muscle fiber atrophy (HP:0003554)1.86996797
135Torticollis (HP:0000473)1.86804626
136Congenital primary aphakia (HP:0007707)1.86312042
137Rough bone trabeculation (HP:0100670)1.86149846
138Hypoplasia of the radius (HP:0002984)1.85525890
139Ectropion (HP:0000656)1.85076048
140Macroorchidism (HP:0000053)1.84463680
141Sensory axonal neuropathy (HP:0003390)1.84337523
142Abnormality of the parathyroid morphology (HP:0011766)1.83820120
143Ventricular fibrillation (HP:0001663)1.83751738
144Depression (HP:0000716)1.83423579
145Dysdiadochokinesis (HP:0002075)1.82493520
146Dry hair (HP:0011359)1.81820186
147Generalized myoclonic seizures (HP:0002123)1.81301072
148Tubulointerstitial nephritis (HP:0001970)1.81009024
149Cerebral hypomyelination (HP:0006808)1.80564821
150Down-sloping shoulders (HP:0200021)1.80427045
151True hermaphroditism (HP:0010459)1.79597435
152Bulbous nose (HP:0000414)1.79564463
153Polyphagia (HP:0002591)1.79380024
154Agammaglobulinemia (HP:0004432)1.79288382
155Missing ribs (HP:0000921)1.79071298
156Dysmetria (HP:0001310)1.78889282
157Forearm undergrowth (HP:0009821)1.78572186
158Rib fusion (HP:0000902)1.77725528
159Abnormal rod and cone electroretinograms (HP:0008323)1.77349125
160Status epilepticus (HP:0002133)1.76570531
161Flared iliac wings (HP:0002869)1.75850280
162Median cleft lip (HP:0000161)1.75551161
163Abnormal vertebral ossification (HP:0100569)1.75489202
164Molar tooth sign on MRI (HP:0002419)1.75025710
165Abnormality of midbrain morphology (HP:0002418)1.75025710
166Congenital, generalized hypertrichosis (HP:0004540)1.74425297
167Abnormality of the labia minora (HP:0012880)1.74412062
168Oligodactyly (hands) (HP:0001180)1.73365877
169Congenital stationary night blindness (HP:0007642)1.72774663
170Hypoplasia of the ulna (HP:0003022)1.71467126
171Large for gestational age (HP:0001520)1.71143319
172Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70871645
173Growth hormone excess (HP:0000845)1.70641938
174Spastic tetraparesis (HP:0001285)1.70367378
175Gastrointestinal atresia (HP:0002589)1.70267364
176Vaginal atresia (HP:0000148)1.70066150
177Dislocated radial head (HP:0003083)1.69705555
178Broad metatarsal (HP:0001783)1.69562615
179Intention tremor (HP:0002080)1.69456837
180Tachypnea (HP:0002789)1.69444388
181Amblyopia (HP:0000646)1.68575209
182Retinal dysplasia (HP:0007973)1.68134299
183Xerostomia (HP:0000217)1.67702350
184Aplasia/Hypoplasia of the fibula (HP:0006492)1.67015308
185Intestinal atresia (HP:0011100)1.66921734
186Tubulointerstitial abnormality (HP:0001969)1.66272830
187Lipid accumulation in hepatocytes (HP:0006561)1.64664429
188Genital tract atresia (HP:0001827)1.64509179
189Male pseudohermaphroditism (HP:0000037)1.64363434
190Focal dystonia (HP:0004373)1.64035178
191Patellar aplasia (HP:0006443)1.63622214
192Hypoplastic left heart (HP:0004383)1.63375865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME15.02732343
2NTRK34.98181885
3EPHA24.11662617
4NEK13.99290501
5PNCK3.79291781
6FRK3.43972122
7MAP3K123.06841040
8LMTK22.74434839
9MET2.72961501
10BMPR1B2.58826679
11IRAK32.44483813
12STK392.35547634
13MAPK152.32421360
14PASK2.26129215
15GRK72.25870373
16MAP3K42.22222035
17MAP3K132.17954470
18CDK82.11823359
19PIK3CA2.10833545
20MAP3K92.03080111
21NTRK21.93935984
22MAP2K41.91027922
23MINK11.85405561
24AKT31.80033456
25MST41.79662293
26VRK21.79608942
27MAP2K71.79354515
28MARK11.76530399
29STK241.73694111
30PAK31.63838701
31OXSR11.61703431
32ZAK1.58132586
33BCKDK1.55666460
34SIK21.39879639
35TLK11.39341635
36BCR1.38023364
37UHMK11.37243209
38MAPKAPK51.34203061
39CAMKK11.34114157
40ARAF1.32296815
41BMX1.31810216
42CDC71.29444767
43KSR21.27386045
44PBK1.25407639
45NEK21.24427686
46IRAK11.18450640
47STK381.15163332
48TGFBR11.14732526
49TNIK1.07730835
50CAMK2A1.06394050
51MAPK131.06260621
52TESK21.05790683
53EPHA41.03629953
54MYLK1.02359178
55FES1.00241860
56DMPK0.98762256
57CAMK2G0.97833043
58IRAK40.96817124
59PDK20.96545115
60CDK50.95462753
61GRK50.94377818
62CDC42BPA0.93003565
63TAOK30.92550587
64HIPK20.91542810
65VRK10.88650888
66CAMK2B0.86442929
67PRKCH0.85081879
68RPS6KB20.84465469
69CAMK10.83946705
70NTRK10.83812324
71STK160.83025328
72PHKG10.82161504
73PHKG20.82161504
74DAPK10.81991720
75PKN10.80427146
76EPHB20.80108853
77CAMKK20.79797235
78NUAK10.79602892
79PRKCG0.79151072
80STK38L0.78798211
81SCYL20.78376923
82MAP3K20.74922485
83CAMK2D0.73053744
84IRAK20.72304363
85WNK40.71970930
86CSNK1G20.70037318
87RET0.66494968
88RIPK10.66102981
89BRAF0.64015760
90TNK20.62940187
91CSNK1G30.62306180
92PRKCI0.62076300
93KSR10.61865680
94CASK0.61740137
95PAK60.61681233
96PRKCQ0.61572258
97SIK10.61496167
98PAK20.60789274
99PRKD20.59641061
100CAMK1G0.58903046
101PRKG20.58728800
102GRK10.55830857
103ADRBK10.54626400
104RPS6KA20.53961712
105MAP3K140.53433558
106CSNK1E0.52465730
107ROCK20.52140905
108WNK30.52032199
109PRKACA0.51257814
110PRKCE0.51184351
111MST1R0.50916526
112DAPK20.49874033
113SGK10.49708658
114CSNK1A1L0.49450946
115FLT30.48872263
116ROCK10.48785860
117MAPK120.48740587
118STK110.48664942
119ADRBK20.48605848
120FGFR20.48535159
121SGK2230.47991719
122SGK4940.47991719
123STK30.46978137
124BRSK10.46220611
125RAF10.46051510
126CDK190.45245034
127CDK140.44345376
128PTK60.43711207
129PLK10.43647644
130CSNK1G10.43332662
131PIK3CG0.42997292
132MARK20.42890015
133MAPK70.42889454
134AURKA0.42772455
135PRKAA20.42340854
136MAP3K10.42196107
137DYRK30.42088705
138TTN0.41919535
139PRKG10.41662628
140MAP3K110.41526825
141WNK10.40765524
142PTK2B0.39602190
143CAMK1D0.38830587
144PRKCB0.35980574
145RPS6KA30.35620324
146INSRR0.34666991
147PTK20.33852647
148LATS20.33774599
149CHEK20.31866911
150MAP2K10.31280918
151MAP2K20.30548308
152RPS6KA10.27037987
153DYRK20.26622525
154TIE10.25969923
155CDK40.25269187
156MAPKAPK30.24444984
157LATS10.23720668
158BRSK20.23460871
159ACVR1B0.22475331
160CSF1R0.22161945
161PRKD30.21172599
162MATK0.19447950

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.79125715
2Nicotine addiction_Homo sapiens_hsa050333.74634004
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.95502367
4GABAergic synapse_Homo sapiens_hsa047272.78991361
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.58822322
6Selenocompound metabolism_Homo sapiens_hsa004502.56502115
7ABC transporters_Homo sapiens_hsa020102.43129723
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35524975
9Sulfur relay system_Homo sapiens_hsa041222.34214763
10Base excision repair_Homo sapiens_hsa034102.33013186
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30436005
12Ribosome_Homo sapiens_hsa030102.28675495
13Morphine addiction_Homo sapiens_hsa050322.26021992
14Cocaine addiction_Homo sapiens_hsa050302.20608930
15Synaptic vesicle cycle_Homo sapiens_hsa047212.20186317
16Oxidative phosphorylation_Homo sapiens_hsa001902.10703369
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08002639
18Amphetamine addiction_Homo sapiens_hsa050312.05346085
19Insulin secretion_Homo sapiens_hsa049111.92429200
20Gastric acid secretion_Homo sapiens_hsa049711.91585564
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90307883
22Dorso-ventral axis formation_Homo sapiens_hsa043201.89763895
23Glutamatergic synapse_Homo sapiens_hsa047241.84822379
24Vibrio cholerae infection_Homo sapiens_hsa051101.81164881
25Nucleotide excision repair_Homo sapiens_hsa034201.79809541
26Cardiac muscle contraction_Homo sapiens_hsa042601.75161347
27Circadian entrainment_Homo sapiens_hsa047131.71872791
28Olfactory transduction_Homo sapiens_hsa047401.71076114
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70822679
30Collecting duct acid secretion_Homo sapiens_hsa049661.65830367
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60861721
32DNA replication_Homo sapiens_hsa030301.60442852
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59802074
34Dopaminergic synapse_Homo sapiens_hsa047281.58068346
35Nitrogen metabolism_Homo sapiens_hsa009101.57733610
36Parkinsons disease_Homo sapiens_hsa050121.56113632
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55042609
38Linoleic acid metabolism_Homo sapiens_hsa005911.53715021
39Cholinergic synapse_Homo sapiens_hsa047251.53034218
40Salivary secretion_Homo sapiens_hsa049701.51251202
41Homologous recombination_Homo sapiens_hsa034401.50438765
42Huntingtons disease_Homo sapiens_hsa050161.48454070
43Peroxisome_Homo sapiens_hsa041461.48126780
44Serotonergic synapse_Homo sapiens_hsa047261.47471791
45Taste transduction_Homo sapiens_hsa047421.46541896
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44038733
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42211292
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.40457664
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38772525
50Long-term depression_Homo sapiens_hsa047301.38087669
51* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36705303
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35954548
53Histidine metabolism_Homo sapiens_hsa003401.35355118
54Long-term potentiation_Homo sapiens_hsa047201.26599606
55Alzheimers disease_Homo sapiens_hsa050101.26101723
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24928551
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24026558
58Thyroid hormone synthesis_Homo sapiens_hsa049181.22679575
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21963625
60Melanogenesis_Homo sapiens_hsa049161.17687498
61Renin secretion_Homo sapiens_hsa049241.16783323
62Butanoate metabolism_Homo sapiens_hsa006501.14204686
63GnRH signaling pathway_Homo sapiens_hsa049121.09879124
64Calcium signaling pathway_Homo sapiens_hsa040201.08989611
65Phenylalanine metabolism_Homo sapiens_hsa003601.08825739
66Fanconi anemia pathway_Homo sapiens_hsa034601.08684494
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08670577
68cAMP signaling pathway_Homo sapiens_hsa040241.04346031
69Melanoma_Homo sapiens_hsa052181.04120741
70Arginine biosynthesis_Homo sapiens_hsa002201.03332884
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03241520
72Oxytocin signaling pathway_Homo sapiens_hsa049211.03145839
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02091431
74Prion diseases_Homo sapiens_hsa050200.98185462
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98009634
76Pyrimidine metabolism_Homo sapiens_hsa002400.97001935
77Gap junction_Homo sapiens_hsa045400.96721988
78Chemical carcinogenesis_Homo sapiens_hsa052040.94625542
79Basal cell carcinoma_Homo sapiens_hsa052170.92558009
80Fatty acid biosynthesis_Homo sapiens_hsa000610.92292477
81Estrogen signaling pathway_Homo sapiens_hsa049150.89768057
82Bile secretion_Homo sapiens_hsa049760.88818324
83Dilated cardiomyopathy_Homo sapiens_hsa054140.84772872
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82670660
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.79783030
86Retinol metabolism_Homo sapiens_hsa008300.78880035
87Type II diabetes mellitus_Homo sapiens_hsa049300.77708771
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.76208923
89Type I diabetes mellitus_Homo sapiens_hsa049400.75918781
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.74102782
91Arginine and proline metabolism_Homo sapiens_hsa003300.73792521
92Axon guidance_Homo sapiens_hsa043600.73686698
93Fat digestion and absorption_Homo sapiens_hsa049750.73414582
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72619673
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71479994
96Arachidonic acid metabolism_Homo sapiens_hsa005900.70398327
97Tyrosine metabolism_Homo sapiens_hsa003500.65652049
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64443626
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64420136
100Ovarian steroidogenesis_Homo sapiens_hsa049130.63959180
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60733806
102Pancreatic secretion_Homo sapiens_hsa049720.60046660
103MAPK signaling pathway_Homo sapiens_hsa040100.57334431
104Ether lipid metabolism_Homo sapiens_hsa005650.56958462
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55866770
106Ras signaling pathway_Homo sapiens_hsa040140.55859318
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53667529
108RNA polymerase_Homo sapiens_hsa030200.53055677
109Pyruvate metabolism_Homo sapiens_hsa006200.52601566
110Hippo signaling pathway_Homo sapiens_hsa043900.52516698
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51933179
112Metabolic pathways_Homo sapiens_hsa011000.51636641
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.51571177
114AMPK signaling pathway_Homo sapiens_hsa041520.50492232
115Primary immunodeficiency_Homo sapiens_hsa053400.49473970
116Alcoholism_Homo sapiens_hsa050340.48607170
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48419698
118Mineral absorption_Homo sapiens_hsa049780.48060162
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.47399350
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47095410
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46921961
122Rheumatoid arthritis_Homo sapiens_hsa053230.44069425
123Fatty acid degradation_Homo sapiens_hsa000710.43829059
124Phototransduction_Homo sapiens_hsa047440.43633621
125Tight junction_Homo sapiens_hsa045300.43172145
126Tryptophan metabolism_Homo sapiens_hsa003800.41913642
127Phagosome_Homo sapiens_hsa041450.41355914
128Sulfur metabolism_Homo sapiens_hsa009200.41259778
129Starch and sucrose metabolism_Homo sapiens_hsa005000.41120228
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40679731
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38903625
132Glycerolipid metabolism_Homo sapiens_hsa005610.38741304
133Glucagon signaling pathway_Homo sapiens_hsa049220.38618566
134Protein export_Homo sapiens_hsa030600.38471771
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37617887
136Purine metabolism_Homo sapiens_hsa002300.33987467
137Hedgehog signaling pathway_Homo sapiens_hsa043400.33394678
138N-Glycan biosynthesis_Homo sapiens_hsa005100.33105912
139ErbB signaling pathway_Homo sapiens_hsa040120.30700698
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.29995381
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28436210
142Fatty acid elongation_Homo sapiens_hsa000620.27479567
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.27013411
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26562819
145Asthma_Homo sapiens_hsa053100.25136573

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