NNAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.37668788
2nucleobase catabolic process (GO:0046113)7.31646804
3response to pheromone (GO:0019236)5.68398935
4axonal fasciculation (GO:0007413)5.63896536
5layer formation in cerebral cortex (GO:0021819)5.51327219
6dendritic spine morphogenesis (GO:0060997)5.33459422
7presynaptic membrane assembly (GO:0097105)5.27451905
8central nervous system projection neuron axonogenesis (GO:0021952)5.17639440
9neuron recognition (GO:0008038)5.15848211
10cell migration in hindbrain (GO:0021535)4.86738727
11neuron cell-cell adhesion (GO:0007158)4.63437434
12dendrite morphogenesis (GO:0048813)4.38540073
13cerebellar Purkinje cell layer development (GO:0021680)4.36938278
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35675841
15negative regulation of catenin import into nucleus (GO:0035414)4.32991913
16negative regulation of microtubule polymerization (GO:0031115)4.27710614
17sequestering of actin monomers (GO:0042989)4.22407878
18substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.17412227
19substrate-independent telencephalic tangential migration (GO:0021826)4.17412227
20vocalization behavior (GO:0071625)4.13704604
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95943139
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.93333742
23establishment of nucleus localization (GO:0040023)3.92958715
24limb bud formation (GO:0060174)3.90453257
25protein localization to synapse (GO:0035418)3.89769466
26central nervous system neuron axonogenesis (GO:0021955)3.87823431
27positive regulation of synapse assembly (GO:0051965)3.76171640
28forebrain neuron differentiation (GO:0021879)3.75920696
29regulation of glutamate receptor signaling pathway (GO:1900449)3.71897425
30neuron fate determination (GO:0048664)3.67011937
31establishment of mitochondrion localization (GO:0051654)3.66404941
32hippocampus development (GO:0021766)3.61235770
33epithelial cell differentiation involved in kidney development (GO:0035850)3.60386300
34regulation of synapse structural plasticity (GO:0051823)3.60299004
35neuron migration (GO:0001764)3.58201861
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.58002198
37behavioral response to nicotine (GO:0035095)3.55367628
38mechanosensory behavior (GO:0007638)3.51471473
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50868536
40cerebral cortex neuron differentiation (GO:0021895)3.48494762
41glutamate receptor signaling pathway (GO:0007215)3.47964808
42axon extension (GO:0048675)3.45651445
43clathrin coat assembly (GO:0048268)3.43704830
44cerebellum development (GO:0021549)3.40789343
45neuronal action potential propagation (GO:0019227)3.40315684
46synapse assembly (GO:0007416)3.40055757
47synaptic vesicle exocytosis (GO:0016079)3.38211113
48positive regulation of action potential (GO:0045760)3.35803660
49neuronal action potential (GO:0019228)3.34865104
50positive regulation of synapse maturation (GO:0090129)3.34683537
51response to auditory stimulus (GO:0010996)3.33015109
52central nervous system neuron development (GO:0021954)3.32424362
53locomotory exploration behavior (GO:0035641)3.32235609
54transmission of nerve impulse (GO:0019226)3.30950774
55synaptic vesicle maturation (GO:0016188)3.30169429
56regulation of synaptic vesicle exocytosis (GO:2000300)3.30157559
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.25524581
58neuronal ion channel clustering (GO:0045161)3.23046782
59postsynaptic membrane organization (GO:0001941)3.21908234
60retinal ganglion cell axon guidance (GO:0031290)3.21046056
61dendritic spine organization (GO:0097061)3.19693321
62negative regulation of axon guidance (GO:1902668)3.19597790
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17929968
64auditory behavior (GO:0031223)3.17693699
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15530887
66negative regulation of axon extension (GO:0030517)3.14893974
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.13278734
68exploration behavior (GO:0035640)3.12003588
69regulation of neuronal synaptic plasticity (GO:0048168)3.08978936
70neurotransmitter-gated ion channel clustering (GO:0072578)3.08796300
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08773582
72ionotropic glutamate receptor signaling pathway (GO:0035235)3.08758655
73cerebellar Purkinje cell differentiation (GO:0021702)3.08563502
74regulation of synapse assembly (GO:0051963)3.07792864
75regulation of synaptic vesicle transport (GO:1902803)3.06835549
76regulation of collateral sprouting (GO:0048670)3.06459055
77startle response (GO:0001964)3.04189625
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.02617090
79membrane depolarization during action potential (GO:0086010)3.02222159
80sympathetic nervous system development (GO:0048485)2.99022032
81regulation of axon extension (GO:0030516)2.98326849
82adult walking behavior (GO:0007628)2.98222465
83positive regulation of dendritic spine development (GO:0060999)2.97051899
84behavioral response to ethanol (GO:0048149)2.95877238
85presynaptic membrane organization (GO:0097090)2.95620347
86neuron projection extension (GO:1990138)2.94856917
87regulation of NFAT protein import into nucleus (GO:0051532)2.93627495
88regulation of synapse organization (GO:0050807)2.89597325
89growth hormone secretion (GO:0030252)2.89414422
90gamma-aminobutyric acid transport (GO:0015812)2.88660467
91axonogenesis (GO:0007409)2.88076671
92spinal cord development (GO:0021510)2.87539325
93homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.87531724
94regulation of respiratory system process (GO:0044065)2.87452281
95neurofilament cytoskeleton organization (GO:0060052)2.86931334
96behavioral response to cocaine (GO:0048148)2.86341967
97regulation of cAMP-dependent protein kinase activity (GO:2000479)2.85065961
98negative regulation of axonogenesis (GO:0050771)2.84099993
99neural tube formation (GO:0001841)2.83533267
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.82702796
101regulation of feeding behavior (GO:0060259)2.82245045
102cell communication by electrical coupling (GO:0010644)2.81989623
103regulation of dopamine secretion (GO:0014059)2.81806879
104cranial nerve morphogenesis (GO:0021602)2.81304925
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81176945
106hindbrain development (GO:0030902)2.80939389
107regulation of axon guidance (GO:1902667)2.80751783
108neuron-neuron synaptic transmission (GO:0007270)2.80709301
109regulation of axon extension involved in axon guidance (GO:0048841)2.79128389
110neuron projection morphogenesis (GO:0048812)2.77716632
111regulation of respiratory gaseous exchange (GO:0043576)2.77459232
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.77062277
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76694694
114proline transport (GO:0015824)2.76208221
115regulation of extent of cell growth (GO:0061387)2.75918975
116peristalsis (GO:0030432)2.75618038
117cerebral cortex radially oriented cell migration (GO:0021799)2.75558293
118somite development (GO:0061053)2.75216877
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75092023
120positive regulation of axon extension (GO:0045773)2.74908334
121negative regulation of dendrite development (GO:2000171)2.74820744
122protein localization to cilium (GO:0061512)2.73701921
123negative regulation of telomere maintenance (GO:0032205)2.72959120
124glutamate secretion (GO:0014047)2.72533555
125synaptic transmission, glutamatergic (GO:0035249)2.71965913
126generation of neurons (GO:0048699)2.71012706
127positive regulation of filopodium assembly (GO:0051491)2.70763384
128regulation of development, heterochronic (GO:0040034)2.68917051
129synaptic vesicle endocytosis (GO:0048488)2.68671578
130semaphorin-plexin signaling pathway (GO:0071526)2.68218098
131regulation of neuron migration (GO:2001222)2.67404849
132glial cell proliferation (GO:0014009)2.65642654
133neurotransmitter secretion (GO:0007269)2.65505739
134dopamine receptor signaling pathway (GO:0007212)2.65223973
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65007555
136nucleus localization (GO:0051647)2.64307181
137establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63934202
138mitochondrion transport along microtubule (GO:0047497)2.63934202
139peptidyl-arginine omega-N-methylation (GO:0035247)2.63341220
140regulation of axonogenesis (GO:0050770)2.63267565
141regulation of timing of cell differentiation (GO:0048505)2.62361347
142synapse organization (GO:0050808)2.61460442
143protein-DNA complex disassembly (GO:0032986)2.61228468
144nucleosome disassembly (GO:0006337)2.61228468
145regulation of autophagic vacuole assembly (GO:2000785)2.60491309
146peptidyl-arginine methylation (GO:0018216)2.60490049
147cerebral cortex cell migration (GO:0021795)2.60171678
148response to histamine (GO:0034776)2.58885584
149membrane hyperpolarization (GO:0060081)2.58784987
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56426480
151cardiac ventricle formation (GO:0003211)2.55807714
152adult behavior (GO:0030534)2.54999526
153membrane depolarization (GO:0051899)2.52133843
154regulation of dendritic spine morphogenesis (GO:0061001)2.51373693
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50695028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.49905209
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.39689625
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.33774114
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14346534
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08477158
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83632305
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81106469
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77431939
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76926515
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76926515
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75342095
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74558153
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.73402825
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.68752983
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.68705628
16REST_21632747_ChIP-Seq_MESCs_Mouse2.49441627
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47173567
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.42324138
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41995673
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.36126783
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30675071
22GBX2_23144817_ChIP-Seq_PC3_Human2.26855552
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.20209972
24VDR_22108803_ChIP-Seq_LS180_Human2.20166225
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20128260
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19816266
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.15178974
28ZNF274_21170338_ChIP-Seq_K562_Hela2.13568072
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13211721
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08895588
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01802407
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.00141171
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94950996
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93598246
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93251438
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.91912617
37OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.87730770
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85246242
39DROSHA_22980978_ChIP-Seq_HELA_Human1.80480802
40RNF2_27304074_Chip-Seq_NSC_Mouse1.77241534
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.75643920
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73488232
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.70047343
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69418818
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67468311
46FUS_26573619_Chip-Seq_HEK293_Human1.66498097
47IGF1R_20145208_ChIP-Seq_DFB_Human1.60781188
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55110240
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49453629
50EWS_26573619_Chip-Seq_HEK293_Human1.47576614
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.46900682
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46166373
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46079610
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45748611
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.44974216
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.39357439
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39257267
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36005211
59TAF15_26573619_Chip-Seq_HEK293_Human1.35537439
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35019706
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34204641
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32733673
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29666434
64AR_21572438_ChIP-Seq_LNCaP_Human1.27242609
65KDM2B_26808549_Chip-Seq_K562_Human1.25538209
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23989351
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23138528
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.20905192
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20547321
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20165104
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17086046
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16470885
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16203768
74BCAT_22108803_ChIP-Seq_LS180_Human1.16031316
75ER_23166858_ChIP-Seq_MCF-7_Human1.15736517
76* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15151335
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15082845
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15082845
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15017908
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14165439
81STAT3_23295773_ChIP-Seq_U87_Human1.09625694
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07471812
83* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07220622
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07184693
85SOX9_26525672_Chip-Seq_HEART_Mouse1.05670152
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05551187
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04783451
88CBP_20019798_ChIP-Seq_JUKART_Human1.03940334
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03940334
90JUN_21703547_ChIP-Seq_K562_Human1.02916857
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02554833
92SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01887794
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.01258722
94TCF4_23295773_ChIP-Seq_U87_Human1.00915752
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00623657
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00476532
97P300_19829295_ChIP-Seq_ESCs_Human1.00139734
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98855658
99AR_19668381_ChIP-Seq_PC3_Human0.98369790
100TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98226007
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97888884
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97382079
103POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.96149635
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96055666
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95854710
106* CTCF_27219007_Chip-Seq_Bcells_Human0.95593570
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.94678426
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93908302
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93873485
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93472418
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91349349
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90416879
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88276142
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87862291
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.87631048
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87556887
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.87040725
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.86253043
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.85652013
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85423408
121AR_25329375_ChIP-Seq_VCAP_Human0.85250593
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84161055
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83653004
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83519866
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.83211465
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82773167
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82200280
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79740746
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78360453
130* RUNX2_22187159_ChIP-Seq_PCA_Human0.78359840
131SMAD4_21799915_ChIP-Seq_A2780_Human0.77697285
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77665697
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75489464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.10754548
2MP0004859_abnormal_synaptic_plasticity3.90440002
3MP0003122_maternal_imprinting3.77793396
4MP0005423_abnormal_somatic_nervous3.75115697
5MP0003880_abnormal_central_pattern3.63933886
6MP0000778_abnormal_nervous_system3.47920974
7MP0006276_abnormal_autonomic_nervous3.39310940
8MP0004270_analgesia2.69572299
9MP0003635_abnormal_synaptic_transmissio2.69271478
10MP0002653_abnormal_ependyma_morphology2.63914745
11MP0001188_hyperpigmentation2.63253901
12MP0005645_abnormal_hypothalamus_physiol2.63163951
13MP0002063_abnormal_learning/memory/cond2.48290489
14MP0002184_abnormal_innervation2.26746584
15MP0003136_yellow_coat_color2.15360282
16MP0002909_abnormal_adrenal_gland1.99181247
17MP0000631_abnormal_neuroendocrine_gland1.96827476
18MP0000569_abnormal_digit_pigmentation1.95525952
19MP0001529_abnormal_vocalization1.94249387
20MP0003121_genomic_imprinting1.94190529
21MP0005646_abnormal_pituitary_gland1.89829123
22MP0010030_abnormal_orbit_morphology1.88090439
23MP0002572_abnormal_emotion/affect_behav1.87107059
24MP0009745_abnormal_behavioral_response1.85299954
25MP0002557_abnormal_social/conspecific_i1.83520812
26MP0002102_abnormal_ear_morphology1.83344851
27MP0002733_abnormal_thermal_nociception1.82907575
28MP0006292_abnormal_olfactory_placode1.74591607
29MP0000955_abnormal_spinal_cord1.70018206
30MP0001486_abnormal_startle_reflex1.69989271
31MP0001440_abnormal_grooming_behavior1.69481785
32MP0008877_abnormal_DNA_methylation1.67431704
33MP0002064_seizures1.66598090
34MP0004811_abnormal_neuron_physiology1.66237047
35MP0002734_abnormal_mechanical_nocicepti1.65774453
36MP0002638_abnormal_pupillary_reflex1.65574720
37MP0005187_abnormal_penis_morphology1.65105910
38MP0003787_abnormal_imprinting1.57023026
39MP0004142_abnormal_muscle_tone1.56219274
40MP0005551_abnormal_eye_electrophysiolog1.54998909
41MP0003861_abnormal_nervous_system1.54366031
42MP0002152_abnormal_brain_morphology1.52560739
43MP0002882_abnormal_neuron_morphology1.51971710
44MP0009780_abnormal_chondrocyte_physiolo1.44425893
45MP0003283_abnormal_digestive_organ1.41835284
46MP0001968_abnormal_touch/_nociception1.41440993
47MP0001984_abnormal_olfaction1.40215942
48MP0003119_abnormal_digestive_system1.39304521
49MP0000537_abnormal_urethra_morphology1.38787338
50MP0008995_early_reproductive_senescence1.37610839
51MP0004858_abnormal_nervous_system1.37271325
52MP0003890_abnormal_embryonic-extraembry1.35299519
53MP0001970_abnormal_pain_threshold1.33461471
54MP0002067_abnormal_sensory_capabilities1.31677417
55MP0008789_abnormal_olfactory_epithelium1.31620441
56MP0001502_abnormal_circadian_rhythm1.27062473
57MP0008961_abnormal_basal_metabolism1.26591490
58MP0005499_abnormal_olfactory_system1.23084255
59MP0005394_taste/olfaction_phenotype1.23084255
60MP0002751_abnormal_autonomic_nervous1.20785739
61MP0004924_abnormal_behavior1.20663896
62MP0005386_behavior/neurological_phenoty1.20663896
63MP0002938_white_spotting1.19491612
64MP0001905_abnormal_dopamine_level1.18114312
65MP0006072_abnormal_retinal_apoptosis1.17114863
66MP0002066_abnormal_motor_capabilities/c1.12467066
67MP0002272_abnormal_nervous_system1.12301752
68MP0003137_abnormal_impulse_conducting1.11922174
69MP0003385_abnormal_body_wall1.11468507
70MP0003938_abnormal_ear_development1.10869155
71MP0009046_muscle_twitch1.10487182
72MP0004133_heterotaxia1.10326092
73MP0002069_abnormal_eating/drinking_beha1.08072127
74MP0003879_abnormal_hair_cell1.06996820
75MP0002752_abnormal_somatic_nervous1.03500901
76MP0004885_abnormal_endolymph1.02835299
77MP0003329_amyloid_beta_deposits1.01743836
78MP0000516_abnormal_urinary_system1.00334469
79MP0005367_renal/urinary_system_phenotyp1.00334469
80MP0003315_abnormal_perineum_morphology0.98839568
81MP0002282_abnormal_trachea_morphology0.97121742
82MP0000026_abnormal_inner_ear0.95561003
83MP0001299_abnormal_eye_distance/0.94806564
84MP0003942_abnormal_urinary_system0.94343765
85MP0008569_lethality_at_weaning0.93792423
86MP0002735_abnormal_chemical_nociception0.93135968
87MP0000049_abnormal_middle_ear0.92521884
88MP0002081_perinatal_lethality0.92287160
89MP0001485_abnormal_pinna_reflex0.91973005
90MP0002928_abnormal_bile_duct0.91630932
91MP0004742_abnormal_vestibular_system0.90659148
92MP0003959_abnormal_lean_body0.90375061
93MP0002089_abnormal_postnatal_growth/wei0.88845871
94MP0000751_myopathy0.88011682
95MP0005248_abnormal_Harderian_gland0.88006504
96MP0002234_abnormal_pharynx_morphology0.87822534
97MP0002736_abnormal_nociception_after0.86667616
98MP0003011_delayed_dark_adaptation0.85977962
99MP0000534_abnormal_ureter_morphology0.85076281
100MP0005195_abnormal_posterior_eye0.84109042
101MP0003937_abnormal_limbs/digits/tail_de0.83337254
102MP0002116_abnormal_craniofacial_bone0.83110633
103MP0001501_abnormal_sleep_pattern0.82867421
104MP0000462_abnormal_digestive_system0.82505813
105MP0003123_paternal_imprinting0.78846549
106MP0000013_abnormal_adipose_tissue0.78368030
107MP0000566_synostosis0.78177427
108MP0005409_darkened_coat_color0.75414837
109MP0003948_abnormal_gas_homeostasis0.75283771
110MP0009053_abnormal_anal_canal0.73913753
111MP0001286_abnormal_eye_development0.73558239
112MP0005253_abnormal_eye_physiology0.73110861
113MP0003634_abnormal_glial_cell0.72710941
114MP0005084_abnormal_gallbladder_morpholo0.72048698
115MP0003755_abnormal_palate_morphology0.71730912
116MP0001963_abnormal_hearing_physiology0.71473753
117MP0002233_abnormal_nose_morphology0.70790798
118MP0002229_neurodegeneration0.70465303
119MP0005391_vision/eye_phenotype0.70093184
120MP0010770_preweaning_lethality0.69223690
121MP0002082_postnatal_lethality0.69223690
122MP0001944_abnormal_pancreas_morphology0.68787508

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.88489142
2Focal motor seizures (HP:0011153)4.52892505
3Failure to thrive in infancy (HP:0001531)4.32480326
4Polyphagia (HP:0002591)4.25644729
5Atonic seizures (HP:0010819)4.02363553
6Focal seizures (HP:0007359)3.87789074
7Retinal dysplasia (HP:0007973)3.64347339
8Febrile seizures (HP:0002373)3.53126779
9Agitation (HP:0000713)3.42332185
10Neoplasm of the heart (HP:0100544)3.41138755
11Abnormal eating behavior (HP:0100738)3.32097569
12Excessive salivation (HP:0003781)3.29660371
13Drooling (HP:0002307)3.29660371
14Myokymia (HP:0002411)3.29075298
15Absence seizures (HP:0002121)3.26648102
16Hyperventilation (HP:0002883)3.12092983
17Amyotrophic lateral sclerosis (HP:0007354)3.08267870
18Cortical dysplasia (HP:0002539)3.05688907
19Supranuclear gaze palsy (HP:0000605)3.01319489
20Oligodactyly (hands) (HP:0001180)2.95193595
21Ulnar claw (HP:0001178)2.92084256
22Type II lissencephaly (HP:0007260)2.91337227
23Limb dystonia (HP:0002451)2.90174272
24Hypoplasia of the brainstem (HP:0002365)2.88394188
25Aplasia/Hypoplasia of the brainstem (HP:0007362)2.88394188
26Hyperthyroidism (HP:0000836)2.87065664
27Lissencephaly (HP:0001339)2.78576336
28Ankle clonus (HP:0011448)2.73026767
29Shoulder girdle muscle weakness (HP:0003547)2.66835086
30Dialeptic seizures (HP:0011146)2.62302661
31Oligomenorrhea (HP:0000876)2.61326786
32Abnormality of midbrain morphology (HP:0002418)2.60468004
33Molar tooth sign on MRI (HP:0002419)2.60468004
34Hemiparesis (HP:0001269)2.58385698
35True hermaphroditism (HP:0010459)2.58325886
36Action tremor (HP:0002345)2.56522574
37Exotropia (HP:0000577)2.56397394
38Chronic hepatic failure (HP:0100626)2.48351994
39Mutism (HP:0002300)2.47938268
40Abnormal hair whorl (HP:0010721)2.46847997
41Hypothermia (HP:0002045)2.46355306
42Nephronophthisis (HP:0000090)2.46138936
43Optic nerve hypoplasia (HP:0000609)2.42180157
44Insomnia (HP:0100785)2.41602118
45Pancreatic cysts (HP:0001737)2.39454448
46Abnormality of the labia minora (HP:0012880)2.38766171
47Hepatoblastoma (HP:0002884)2.38484992
48Hyperacusis (HP:0010780)2.37124804
49Atelectasis (HP:0100750)2.35708771
50Volvulus (HP:0002580)2.35140740
51Megalencephaly (HP:0001355)2.35098864
52Elfin facies (HP:0004428)2.34703457
53Gait imbalance (HP:0002141)2.33983009
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33364729
55Short 4th metacarpal (HP:0010044)2.32230476
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32230476
57Esotropia (HP:0000565)2.31315843
58Pachygyria (HP:0001302)2.30478048
59Oligodactyly (HP:0012165)2.29709690
60Lymphangioma (HP:0100764)2.29139949
61High anterior hairline (HP:0009890)2.26668734
62Sleep apnea (HP:0010535)2.23973515
63Depression (HP:0000716)2.22363114
64Amblyopia (HP:0000646)2.20608900
65Anteriorly placed anus (HP:0001545)2.20359400
66Shawl scrotum (HP:0000049)2.20113133
67Abnormality of the astrocytes (HP:0100707)2.17559311
68Astrocytoma (HP:0009592)2.17559311
69Specific learning disability (HP:0001328)2.16949535
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.16645109
71Inability to walk (HP:0002540)2.14134370
72Pancreatic fibrosis (HP:0100732)2.12544274
73Dysdiadochokinesis (HP:0002075)2.11557415
74Renal duplication (HP:0000075)2.11288614
75Abnormality of salivation (HP:0100755)2.09267002
76Progressive cerebellar ataxia (HP:0002073)2.08020969
77Hypsarrhythmia (HP:0002521)2.06856899
78Split foot (HP:0001839)2.06645625
79Septo-optic dysplasia (HP:0100842)2.04301823
80Midline defect of the nose (HP:0004122)2.04291816
81Anophthalmia (HP:0000528)2.03897758
82EEG with generalized epileptiform discharges (HP:0011198)2.03802810
83Intestinal atresia (HP:0011100)2.03381081
84Spastic tetraplegia (HP:0002510)2.02470372
85Narrow nasal bridge (HP:0000446)2.00623054
86Broad-based gait (HP:0002136)2.00570217
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00006612
88Overriding aorta (HP:0002623)1.99087876
89Genetic anticipation (HP:0003743)1.97559782
90Poor suck (HP:0002033)1.97545575
91Sporadic (HP:0003745)1.97385283
92Renovascular hypertension (HP:0100817)1.97204501
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.97188630
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97188630
95Precocious puberty (HP:0000826)1.96716057
96Hip dysplasia (HP:0001385)1.96620101
97Prominent supraorbital ridges (HP:0000336)1.96250836
98Gaze-evoked nystagmus (HP:0000640)1.95993279
99Urinary urgency (HP:0000012)1.95830013
100Epileptiform EEG discharges (HP:0011182)1.95566364
101Spastic gait (HP:0002064)1.95531106
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95465684
103Akinesia (HP:0002304)1.95192071
104Anterior segment dysgenesis (HP:0007700)1.94773753
105Patellar aplasia (HP:0006443)1.94310369
106Anencephaly (HP:0002323)1.93771373
107Epileptic encephalopathy (HP:0200134)1.93168818
108Hypoventilation (HP:0002791)1.92800375
109Patellar dislocation (HP:0002999)1.92106703
110Esophageal atresia (HP:0002032)1.90524124
111Progressive inability to walk (HP:0002505)1.90166856
112Abnormality of the 4th metacarpal (HP:0010012)1.89898765
113Concave nail (HP:0001598)1.89705664
114Scrotal hypoplasia (HP:0000046)1.89612893
115Pendular nystagmus (HP:0012043)1.88903017
116Abnormality of the renal medulla (HP:0100957)1.88862738
117Narrow forehead (HP:0000341)1.88691673
118Ependymoma (HP:0002888)1.88239940
119Pheochromocytoma (HP:0002666)1.87168404
120Medial flaring of the eyebrow (HP:0010747)1.87004789
121Macroorchidism (HP:0000053)1.86966041
122Generalized tonic-clonic seizures (HP:0002069)1.86907419
123Rib fusion (HP:0000902)1.86732920
124Rimmed vacuoles (HP:0003805)1.86648448
125Pelvic girdle muscle weakness (HP:0003749)1.86512128
126Abnormality of the corticospinal tract (HP:0002492)1.86087041
127Renal hypoplasia (HP:0000089)1.85189169
128Menstrual irregularities (HP:0000858)1.84930040
129Papilledema (HP:0001085)1.83055981
130Large eyes (HP:0001090)1.82849733
131Labial hypoplasia (HP:0000066)1.81589294
132Open mouth (HP:0000194)1.80934180
133Truncal ataxia (HP:0002078)1.80556656
134Hypoplastic female external genitalia (HP:0012815)1.79807947
135Abnormal respiratory epithelium morphology (HP:0012253)1.79805927
136Abnormal respiratory motile cilium morphology (HP:0005938)1.79805927
137Abnormal ciliary motility (HP:0012262)1.79615211
138Growth hormone deficiency (HP:0000824)1.79444587
139Sacral dimple (HP:0000960)1.79367550
140Megalocornea (HP:0000485)1.79314998
141Hemivertebrae (HP:0002937)1.78293918
142Autism (HP:0000717)1.77698395
143Vaginal atresia (HP:0000148)1.77669133
144Hypoplasia of the corpus callosum (HP:0002079)1.76879723
145Supernumerary spleens (HP:0009799)1.76722658
146Poor eye contact (HP:0000817)1.76558144
147Abnormality of the hip-girdle musculature (HP:0001445)1.76228996
148Abnormality of the musculature of the pelvis (HP:0001469)1.76228996
149Pointed chin (HP:0000307)1.76174643
150Apathy (HP:0000741)1.76125999
151Synostosis involving the elbow (HP:0003938)1.75821906
152Humeroradial synostosis (HP:0003041)1.75821906
153Neurofibrillary tangles (HP:0002185)1.75544202
154Genital tract atresia (HP:0001827)1.74740959
155Torticollis (HP:0000473)1.73996892
156Congenital glaucoma (HP:0001087)1.73915133
157Aplasia/Hypoplasia of the patella (HP:0006498)1.72903275
158Anxiety (HP:0000739)1.71915366
159Medulloblastoma (HP:0002885)1.71625496
160Nephrogenic diabetes insipidus (HP:0009806)1.70891178
161Abnormality of the lower motor neuron (HP:0002366)1.70693242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.42307328
2NTRK23.18659289
3SIK32.99246784
4KSR12.75442322
5DYRK22.71240717
6INSRR2.63175799
7BCR2.35000283
8MAP3K92.27748532
9MAPK132.15872348
10EPHB22.13799737
11SIK22.12033172
12MINK12.08612958
13TSSK62.08551444
14FGFR22.08385958
15TYRO32.03517745
16MAP4K21.95714735
17UHMK11.86420332
18LIMK11.81476249
19ERBB31.77910975
20NTRK31.69030848
21MAP3K121.65586711
22MAP3K41.65437063
23PAK61.64560353
24ADRBK21.61477614
25PINK11.47433857
26PHKG21.44836652
27PHKG11.44836652
28PDGFRA1.39804225
29MAP2K71.37111639
30WNK31.33856497
31PAK31.32648616
32DYRK1B1.31053220
33DYRK31.28973242
34PNCK1.27841331
35IRAK21.26541024
36EPHA31.25168523
37ERBB21.23183292
38CDK51.21143351
39CAMK1G1.18358165
40ICK1.17868917
41CSNK1G21.14910570
42CDK181.11869608
43CSNK1G31.11771720
44CASK1.04715138
45TNIK1.04261978
46MAP2K41.03936592
47LATS21.03242644
48TRIM281.02478000
49MARK21.02442083
50RPS6KA20.98930230
51CSNK1A1L0.98446636
52CDK150.97476018
53WEE10.97364069
54CDK140.96022543
55DYRK1A0.93740110
56DAPK20.88320400
57MKNK20.87632493
58FGFR40.85892936
59CDK11A0.85604042
60PASK0.82449786
61TLK10.81045468
62EPHA40.80953352
63OXSR10.80045018
64RIPK10.77512776
65FER0.75941386
66PKN10.75089001
67CSNK1G10.74872670
68KSR20.73715604
69WNK40.72413795
70PRKCZ0.71431743
71MAP3K110.65888308
72RET0.64222311
73MAPK90.62994168
74TESK20.62090572
75PRKD30.61257490
76CAMK1D0.61255975
77MAPK150.59622574
78GRK10.59396510
79SGK20.57454005
80TESK10.56824912
81PRKCG0.56071259
82FGFR10.55132457
83DDR20.53268155
84TAOK30.53089885
85FGFR30.52663514
86VRK10.52440972
87CDC42BPA0.50788023
88CAMKK10.50665130
89LMTK20.50208123
90IRAK10.49807581
91TGFBR10.49657577
92GRK70.48827785
93BMPR1B0.48526709
94PLK20.48286796
95SRPK10.46405262
96ADRBK10.45670924
97MKNK10.45047127
98HIPK20.44692073
99CDK30.44216114
100CDK190.44198072
101TRIB30.44115515
102ROCK10.43951860
103STK390.43726523
104FRK0.43341642
105PRKAA10.42439017
106PRKACA0.41124598
107CSNK1D0.40889089
108MAPK40.40130961
109MAPKAPK50.40111337
110SGK10.39143197
111ROCK20.38849578
112PRKACB0.38733317
113SGK2230.38209441
114SGK4940.38209441
115MAPK100.37359765
116STK110.36683407
117PRKG10.36439714
118PRKD20.36313764
119RPS6KA50.35894288
120CAMK40.35468153
121PRKCI0.35430557
122CCNB10.34250654
123CAMK2B0.34096817
124PRKCE0.33802747
125CSNK1A10.32055815
126FYN0.30753319
127NME10.30482877
128CAMK2A0.29959079
129CSNK1E0.28701717
130AKT20.28659694
131RPS6KA30.27708585
132TAOK10.27223073
133SIK10.26743151
134MAPK80.26720077
135MAP3K50.26301896

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043603.03652464
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84123705
3Nicotine addiction_Homo sapiens_hsa050332.72238409
4Cocaine addiction_Homo sapiens_hsa050302.50945345
5Oxidative phosphorylation_Homo sapiens_hsa001902.36832916
6GABAergic synapse_Homo sapiens_hsa047272.34615160
7Parkinsons disease_Homo sapiens_hsa050122.25752454
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.18193885
9Synaptic vesicle cycle_Homo sapiens_hsa047212.14636193
10Dopaminergic synapse_Homo sapiens_hsa047282.09637588
11Circadian entrainment_Homo sapiens_hsa047132.04479279
12Glutamatergic synapse_Homo sapiens_hsa047241.99768822
13Insulin secretion_Homo sapiens_hsa049111.86928163
14Morphine addiction_Homo sapiens_hsa050321.86290468
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84580292
16Gap junction_Homo sapiens_hsa045401.83114551
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.82453882
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75328728
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72440833
20Amphetamine addiction_Homo sapiens_hsa050311.68717434
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.65827281
22Colorectal cancer_Homo sapiens_hsa052101.65812377
23Alzheimers disease_Homo sapiens_hsa050101.57634626
24Protein export_Homo sapiens_hsa030601.56676408
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54113822
26Cholinergic synapse_Homo sapiens_hsa047251.52980283
27Endometrial cancer_Homo sapiens_hsa052131.50455973
28Basal cell carcinoma_Homo sapiens_hsa052171.50343878
29Serotonergic synapse_Homo sapiens_hsa047261.43071692
30Type II diabetes mellitus_Homo sapiens_hsa049301.42414223
31Huntingtons disease_Homo sapiens_hsa050161.40007711
32Olfactory transduction_Homo sapiens_hsa047401.35672657
33Long-term potentiation_Homo sapiens_hsa047201.32004875
34ErbB signaling pathway_Homo sapiens_hsa040121.31361053
35Alcoholism_Homo sapiens_hsa050341.30691909
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30001897
37Taste transduction_Homo sapiens_hsa047421.26459161
38Long-term depression_Homo sapiens_hsa047301.20974115
39Estrogen signaling pathway_Homo sapiens_hsa049151.20370975
40Melanogenesis_Homo sapiens_hsa049161.19886007
41Oxytocin signaling pathway_Homo sapiens_hsa049211.19201244
42Vibrio cholerae infection_Homo sapiens_hsa051101.19085733
43GnRH signaling pathway_Homo sapiens_hsa049121.17319180
44Renin secretion_Homo sapiens_hsa049241.13317618
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13281904
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11209159
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10547616
48Renal cell carcinoma_Homo sapiens_hsa052111.08503445
49Wnt signaling pathway_Homo sapiens_hsa043101.08158057
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07113764
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04313179
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04044552
53Hedgehog signaling pathway_Homo sapiens_hsa043401.03258493
54Gastric acid secretion_Homo sapiens_hsa049711.01623339
55Hippo signaling pathway_Homo sapiens_hsa043901.01542472
56Glioma_Homo sapiens_hsa052141.00744109
57Notch signaling pathway_Homo sapiens_hsa043300.99809778
58Selenocompound metabolism_Homo sapiens_hsa004500.99657742
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.99111927
60Cardiac muscle contraction_Homo sapiens_hsa042600.96838090
61Butanoate metabolism_Homo sapiens_hsa006500.96467572
62Choline metabolism in cancer_Homo sapiens_hsa052310.95438919
63Oocyte meiosis_Homo sapiens_hsa041140.94041752
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93393645
65Prion diseases_Homo sapiens_hsa050200.92848401
66Salivary secretion_Homo sapiens_hsa049700.92063054
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92024184
68Collecting duct acid secretion_Homo sapiens_hsa049660.89896493
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88970651
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88801218
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88205128
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87075840
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86345068
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84354686
75Basal transcription factors_Homo sapiens_hsa030220.84326676
76cAMP signaling pathway_Homo sapiens_hsa040240.84179996
77Insulin signaling pathway_Homo sapiens_hsa049100.83634183
78N-Glycan biosynthesis_Homo sapiens_hsa005100.83537552
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81414498
80AMPK signaling pathway_Homo sapiens_hsa041520.80402195
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.80057465
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79752766
83VEGF signaling pathway_Homo sapiens_hsa043700.79083834
84Circadian rhythm_Homo sapiens_hsa047100.77817151
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77053120
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76418227
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74062352
88MAPK signaling pathway_Homo sapiens_hsa040100.71485869
89Nitrogen metabolism_Homo sapiens_hsa009100.71131357
90Viral myocarditis_Homo sapiens_hsa054160.70963250
91mTOR signaling pathway_Homo sapiens_hsa041500.68749879
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68225531
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66595832
94Linoleic acid metabolism_Homo sapiens_hsa005910.66257711
95Ether lipid metabolism_Homo sapiens_hsa005650.65191004
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64826482
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63305916
98Regulation of autophagy_Homo sapiens_hsa041400.62459382
99Ras signaling pathway_Homo sapiens_hsa040140.61476031
100Calcium signaling pathway_Homo sapiens_hsa040200.61130850
101Non-small cell lung cancer_Homo sapiens_hsa052230.60534783
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60123896
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59476002
104Glucagon signaling pathway_Homo sapiens_hsa049220.58149800
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57641438
106Dilated cardiomyopathy_Homo sapiens_hsa054140.56286356
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55037895
108TGF-beta signaling pathway_Homo sapiens_hsa043500.54909210
109mRNA surveillance pathway_Homo sapiens_hsa030150.53476990
110Thyroid hormone synthesis_Homo sapiens_hsa049180.51960444
111Rap1 signaling pathway_Homo sapiens_hsa040150.51695542
112Tryptophan metabolism_Homo sapiens_hsa003800.50608342
113Endocytosis_Homo sapiens_hsa041440.50539063
114Phototransduction_Homo sapiens_hsa047440.50427818
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.50296566
116Dorso-ventral axis formation_Homo sapiens_hsa043200.48966730
117Steroid biosynthesis_Homo sapiens_hsa001000.48546514
118MicroRNAs in cancer_Homo sapiens_hsa052060.47948816
119RNA polymerase_Homo sapiens_hsa030200.47745693
120Prolactin signaling pathway_Homo sapiens_hsa049170.47676415
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47667800
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46656945
123Chronic myeloid leukemia_Homo sapiens_hsa052200.45494378
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43429735
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42780076
126Fatty acid elongation_Homo sapiens_hsa000620.42085307
127Type I diabetes mellitus_Homo sapiens_hsa049400.41433327
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37396686
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35145906
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.34520968
131Ovarian steroidogenesis_Homo sapiens_hsa049130.31813066
132Propanoate metabolism_Homo sapiens_hsa006400.31619356
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30427882
134Folate biosynthesis_Homo sapiens_hsa007900.28205909
135Tight junction_Homo sapiens_hsa045300.28025445
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26149285

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