NNMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.44897064
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44897064
3L-phenylalanine metabolic process (GO:0006558)7.16823853
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16823853
5aromatic amino acid family catabolic process (GO:0009074)6.56358691
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.95221779
7urea cycle (GO:0000050)5.80272304
8urea metabolic process (GO:0019627)5.80272304
9indole-containing compound catabolic process (GO:0042436)5.76013030
10indolalkylamine catabolic process (GO:0046218)5.76013030
11tryptophan catabolic process (GO:0006569)5.76013030
12complement activation, alternative pathway (GO:0006957)5.59021070
13bile acid biosynthetic process (GO:0006699)5.53030034
14kynurenine metabolic process (GO:0070189)5.52070890
15tryptophan metabolic process (GO:0006568)5.39943898
16sulfur amino acid catabolic process (GO:0000098)5.38290018
17negative regulation of fibrinolysis (GO:0051918)5.36575029
18nitrogen cycle metabolic process (GO:0071941)5.34356578
19glyoxylate metabolic process (GO:0046487)5.33704634
20regulation of protein activation cascade (GO:2000257)5.32112298
21peptidyl-glutamic acid carboxylation (GO:0017187)5.23161149
22protein carboxylation (GO:0018214)5.23161149
23alpha-linolenic acid metabolic process (GO:0036109)5.20993047
24cysteine metabolic process (GO:0006534)5.15398037
25high-density lipoprotein particle remodeling (GO:0034375)5.10556378
26regulation of fibrinolysis (GO:0051917)5.10135520
27regulation of triglyceride catabolic process (GO:0010896)5.00242431
28regulation of complement activation (GO:0030449)4.99719325
29regulation of plasminogen activation (GO:0010755)4.97894522
30homocysteine metabolic process (GO:0050667)4.97075289
31collagen fibril organization (GO:0030199)4.90631065
32serine family amino acid catabolic process (GO:0009071)4.90019691
33tyrosine metabolic process (GO:0006570)4.85386257
34aromatic amino acid family metabolic process (GO:0009072)4.74753601
35bile acid metabolic process (GO:0008206)4.72075255
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65582724
37acylglycerol homeostasis (GO:0055090)4.59223902
38triglyceride homeostasis (GO:0070328)4.59223902
39alpha-amino acid catabolic process (GO:1901606)4.51328752
40lysine catabolic process (GO:0006554)4.50173591
41lysine metabolic process (GO:0006553)4.50173591
42regulation of cholesterol esterification (GO:0010872)4.49576127
43plasma lipoprotein particle clearance (GO:0034381)4.48454582
44reverse cholesterol transport (GO:0043691)4.45854177
45protein-lipid complex remodeling (GO:0034368)4.43873660
46macromolecular complex remodeling (GO:0034367)4.43873660
47plasma lipoprotein particle remodeling (GO:0034369)4.43873660
48amino-acid betaine metabolic process (GO:0006577)4.39474183
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.30871892
50coenzyme catabolic process (GO:0009109)4.30364403
51phospholipid efflux (GO:0033700)4.18198172
52cellular amino acid catabolic process (GO:0009063)4.16711402
53negative regulation of protein activation cascade (GO:2000258)4.16149805
54cell migration involved in heart development (GO:0060973)4.15937213
55arginine metabolic process (GO:0006525)4.13856072
56protein heterotrimerization (GO:0070208)4.13197788
57epoxygenase P450 pathway (GO:0019373)4.10929570
58negative regulation of cholesterol transport (GO:0032375)4.03626939
59negative regulation of sterol transport (GO:0032372)4.03626939
60indolalkylamine metabolic process (GO:0006586)4.01883415
61glycine metabolic process (GO:0006544)3.96794447
62amine catabolic process (GO:0009310)3.95273675
63cellular biogenic amine catabolic process (GO:0042402)3.95273675
64fibrinolysis (GO:0042730)3.94209724
65extracellular fibril organization (GO:0043206)3.94201871
66endodermal cell differentiation (GO:0035987)3.93710846
67negative regulation of complement activation (GO:0045916)3.91941205
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.91846583
69cellular glucuronidation (GO:0052695)3.90452143
70glutamate metabolic process (GO:0006536)3.90021724
71mesenchymal-epithelial cell signaling (GO:0060638)3.89786439
72serine family amino acid metabolic process (GO:0009069)3.89736958
73positive regulation of lipid catabolic process (GO:0050996)3.88571805
74negative regulation of lipase activity (GO:0060192)3.88359003
75cellular ketone body metabolic process (GO:0046950)3.86115567
76cellular modified amino acid catabolic process (GO:0042219)3.85795346
77peptidyl-proline hydroxylation (GO:0019511)3.85226996
78acetyl-CoA metabolic process (GO:0006084)3.84771458
79bile acid and bile salt transport (GO:0015721)3.84444128
80imidazole-containing compound metabolic process (GO:0052803)3.83686943
81aldehyde catabolic process (GO:0046185)3.83539126
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.82487989
83benzene-containing compound metabolic process (GO:0042537)3.82125859
84acute-phase response (GO:0006953)3.80506361
85cholesterol efflux (GO:0033344)3.79452658
86skin morphogenesis (GO:0043589)3.79098425
87complement activation (GO:0006956)3.73800592
88regulation of integrin-mediated signaling pathway (GO:2001044)3.72192381
89cytolysis (GO:0019835)3.71689970
90ethanol oxidation (GO:0006069)3.71419079
91cofactor catabolic process (GO:0051187)3.70582106
92carboxylic acid catabolic process (GO:0046395)3.69330092
93organic acid catabolic process (GO:0016054)3.69330092
94complement activation, classical pathway (GO:0006958)3.69007375
95dicarboxylic acid biosynthetic process (GO:0043650)3.68811181
96cell adhesion mediated by integrin (GO:0033627)3.67993350
97serine family amino acid biosynthetic process (GO:0009070)3.66349149
98positive regulation of lipoprotein lipase activity (GO:0051006)3.65015844
99positive regulation of triglyceride lipase activity (GO:0061365)3.65015844
100opsonization (GO:0008228)3.64686716
101plasma lipoprotein particle assembly (GO:0034377)3.64440004
102drug catabolic process (GO:0042737)3.64406900
103protein activation cascade (GO:0072376)3.62873168
104type B pancreatic cell proliferation (GO:0044342)3.59860644
1052-oxoglutarate metabolic process (GO:0006103)3.58077229
106keratan sulfate catabolic process (GO:0042340)3.57202287
107cholesterol homeostasis (GO:0042632)3.56197891
108sterol homeostasis (GO:0055092)3.50525333
109fatty acid beta-oxidation (GO:0006635)3.50195698
110blood coagulation, intrinsic pathway (GO:0007597)3.49820958
111regulation of bile acid biosynthetic process (GO:0070857)3.49510340
112phospholipid homeostasis (GO:0055091)3.49508248
113fatty acid oxidation (GO:0019395)3.48857050
114uronic acid metabolic process (GO:0006063)3.47880091
115glucuronate metabolic process (GO:0019585)3.47880091
116short-chain fatty acid metabolic process (GO:0046459)3.46874579
117cellular response to zinc ion (GO:0071294)3.45954717
118heme transport (GO:0015886)3.44694365
119omega-hydroxylase P450 pathway (GO:0097267)3.44651935
120membrane raft organization (GO:0031579)3.39684446
121positive regulation of extracellular matrix organization (GO:1903055)3.39230468
122fibril organization (GO:0097435)3.38877438
123sequestering of extracellular ligand from receptor (GO:0035581)3.35935099
124protein hydroxylation (GO:0018126)3.34315039
125kidney mesenchyme development (GO:0072074)3.33849124
126regulation of apoptotic process involved in morphogenesis (GO:1902337)3.27193574
127peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.26910555
128metanephric mesenchyme development (GO:0072075)3.18161470
129protein retention in ER lumen (GO:0006621)3.16602347
130extracellular matrix assembly (GO:0085029)3.16318693
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16265000
132regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13856274
133regulation of metalloenzyme activity (GO:0048552)3.13711006
134venous blood vessel morphogenesis (GO:0048845)3.11655362
135endocrine hormone secretion (GO:0060986)3.08766399
136lymphangiogenesis (GO:0001946)3.07878876
137tooth mineralization (GO:0034505)3.05192913
138regulation of extracellular matrix disassembly (GO:0010715)3.04518574
139negative regulation of coagulation (GO:0050819)3.03746096
140endothelial cell morphogenesis (GO:0001886)3.02078601
141basement membrane organization (GO:0071711)3.01185547
142vascular endothelial growth factor signaling pathway (GO:0038084)3.00414201
143glomerular basement membrane development (GO:0032836)3.00355078
144wound healing, spreading of epidermal cells (GO:0035313)2.92544238
145negative regulation of wound healing (GO:0061045)2.91680169
1464-hydroxyproline metabolic process (GO:0019471)2.90593905
147collagen metabolic process (GO:0032963)2.90508719
148adhesion of symbiont to host cell (GO:0044650)2.89875635
149virion attachment to host cell (GO:0019062)2.89875635
150negative regulation of blood coagulation (GO:0030195)2.89470438
151negative regulation of hemostasis (GO:1900047)2.89470438
152negative regulation of fatty acid transport (GO:2000192)2.88267887
153extracellular matrix disassembly (GO:0022617)2.86644108
154extracellular matrix organization (GO:0030198)2.84750211
155negative regulation of chondrocyte differentiation (GO:0032331)2.84133371
156extracellular structure organization (GO:0043062)2.83703462
157barbed-end actin filament capping (GO:0051016)2.81974412
158blood vessel maturation (GO:0001955)2.79417261
159negative regulation of endothelial cell proliferation (GO:0001937)2.78429817
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77096636
161hyaluronan catabolic process (GO:0030214)2.76465679
162negative regulation of nitric-oxide synthase activity (GO:0051001)2.74163537
163multicellular organismal macromolecule metabolic process (GO:0044259)2.72372155
164negative regulation of humoral immune response (GO:0002921)2.70972674
165positive regulation of osteoblast proliferation (GO:0033690)2.70154578
166collagen catabolic process (GO:0030574)2.67030010
167acute inflammatory response (GO:0002526)2.65681736
168regulation of apoptotic cell clearance (GO:2000425)2.65244044
169multicellular organismal metabolic process (GO:0044236)2.63445842
170substrate adhesion-dependent cell spreading (GO:0034446)2.61937589
171nucleotide-sugar biosynthetic process (GO:0009226)2.60238052
172cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60029545
173cellular response to cadmium ion (GO:0071276)2.59532555
174hemidesmosome assembly (GO:0031581)2.59444256
175positive regulation of endothelial cell apoptotic process (GO:2000353)2.59012254
176apoptotic cell clearance (GO:0043277)2.58464056
177COPI coating of Golgi vesicle (GO:0048205)2.58174145
178Golgi transport vesicle coating (GO:0048200)2.58174145
179COPII vesicle coating (GO:0048208)2.57224224
180exogenous drug catabolic process (GO:0042738)2.57095486
181adhesion of symbiont to host (GO:0044406)2.55334578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.96876714
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74293287
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.52611937
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.40349069
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.14685410
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13189608
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.90683283
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92457198
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.79280979
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.61938349
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.90395522
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84442074
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.80505744
14BRD4_25478319_ChIP-Seq_HGPS_Human2.52565933
15* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.52051662
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.49481261
17CLOCK_20551151_ChIP-Seq_293T_Human2.31265460
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04610918
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.01917515
20* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4040915
21* GATA2_21666600_ChIP-Seq_HMVEC_Human1.98814226
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95327548
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95327548
24* TP53_18474530_ChIP-ChIP_U2OS_Human1.91131987
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87007825
26JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86046151
27* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.85151316
28JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77362041
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56207571
30GATA1_22025678_ChIP-Seq_K562_Human1.56122682
31TP53_16413492_ChIP-PET_HCT116_Human1.49931780
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.49296475
33MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47454665
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.44706703
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42728558
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.41373247
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40776968
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39980201
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38730683
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33597975
41SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33306200
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31084853
43HTT_18923047_ChIP-ChIP_STHdh_Human1.29169133
44* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28931831
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25781274
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24569154
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23450564
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22683258
49* UBF1/2_26484160_Chip-Seq_HMECs_Human1.22349041
50SA1_22415368_ChIP-Seq_MEFs_Mouse1.19780998
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18954024
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16908216
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16795269
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15794036
55TP53_22127205_ChIP-Seq_IMR90_Human1.15599406
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14412372
57ATF3_27146783_Chip-Seq_COLON_Human1.12909791
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11051687
59* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10854296
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10423256
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09671183
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09352655
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03999080
64* PIAS1_25552417_ChIP-Seq_VCAP_Human1.01746962
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98769023
66ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97799166
67* TRIM28_21343339_ChIP-Seq_HEK293_Human0.96873106
68TP63_23658742_ChIP-Seq_EP156T_Human0.94886437
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91834624
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91124256
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90959251
72* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90572662
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89675309
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88549924
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88290286
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88202283
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88202283
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86866665
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86767535
80IRF8_22096565_ChIP-ChIP_GC-B_Human0.85406397
81TP53_23651856_ChIP-Seq_MEFs_Mouse0.85370606
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84848014
83SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84112210
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83991011
85EED_16625203_ChIP-ChIP_MESCs_Mouse0.83041554
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82808429
87* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82205532
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81171852
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80975863
90AHR_22903824_ChIP-Seq_MCF-7_Human0.80356109
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.79881669
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79820806
93* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79788986
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79637265
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78737995
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78448002
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78318429
98PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.77810283
99* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76242495
100GATA4_25053715_ChIP-Seq_YYC3_Human0.74536294
101* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72678655
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72575130
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68964258
104ZNF263_19887448_ChIP-Seq_K562_Human0.68338040
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67260874
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.66813627
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65439915
108ESR1_21235772_ChIP-Seq_MCF-7_Human0.65259748
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64469498
110* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62314454
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61210849
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60773595
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59127459
114LXR_22292898_ChIP-Seq_THP-1_Human0.58594490
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.57789848
116CEBPB_22108803_ChIP-Seq_LS180_Human0.56271438
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.55960664
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55231220
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53968918
120* SOX2_20726797_ChIP-Seq_SW620_Human0.51789697
121EGR1_19032775_ChIP-ChIP_M12_Human0.51756743
122* AR_20517297_ChIP-Seq_VCAP_Human0.50280564
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50248730
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.48470102
125* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.47167105
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46935339
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46873134
128MYC_19915707_ChIP-ChIP_AK7_Human0.46261120
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.45782716
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45596658
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.45384950
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45065207
133BCAT_22108803_ChIP-Seq_LS180_Human0.44408314
134P53_21459846_ChIP-Seq_SAOS-2_Human0.44268672
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.43388435
136* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42955840
137* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.42451229
138* CBP_21632823_ChIP-Seq_H3396_Human0.41339214
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.41045346
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39806889
141* CJUN_26792858_Chip-Seq_BT549_Human0.39453774
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.38744505
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38590699
144RACK7_27058665_Chip-Seq_MCF-7_Human0.38405137
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38388387
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.38243546
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.38186821
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.38063128
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.38063128
150STAT1_17558387_ChIP-Seq_HELA_Human0.37585439
151TAF2_19829295_ChIP-Seq_ESCs_Human0.36802834
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.36525774
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.36257782
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.35878165
155ERG_20517297_ChIP-Seq_VCAP_Human0.35111101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.59016995
2MP0005360_urolithiasis7.12483234
3MP0005085_abnormal_gallbladder_physiolo5.94075995
4MP0005365_abnormal_bile_salt5.82259142
5MP0008875_abnormal_xenobiotic_pharmacok4.86672616
6MP0004272_abnormal_basement_membrane4.07384950
7MP0003950_abnormal_plasma_membrane3.97839888
8MP0003806_abnormal_nucleotide_metabolis3.83633568
9MP0003252_abnormal_bile_duct3.65427027
10MP0010329_abnormal_lipoprotein_level3.65148772
11MP0009840_abnormal_foam_cell3.10275831
12MP0001958_emphysema3.07363445
13MP0003191_abnormal_cellular_cholesterol2.81916959
14MP0005332_abnormal_amino_acid2.78444236
15MP0003195_calcinosis2.60100034
16MP0005083_abnormal_biliary_tract2.58222394
17MP0006054_spinal_hemorrhage2.43069779
18MP0001666_abnormal_nutrient_absorption2.30435681
19MP0005670_abnormal_white_adipose2.26335367
20MP0005257_abnormal_intraocular_pressure2.25024865
21MP0002118_abnormal_lipid_homeostasis2.19466616
22MP0000609_abnormal_liver_physiology2.15348362
23MP0003566_abnormal_cell_adhesion2.14096304
24MP0004019_abnormal_vitamin_homeostasis2.00791990
25MP0003705_abnormal_hypodermis_morpholog1.96314023
26MP0000013_abnormal_adipose_tissue1.84035647
27MP0005319_abnormal_enzyme/_coenzyme1.82064201
28MP0009780_abnormal_chondrocyte_physiolo1.80409071
29MP0002108_abnormal_muscle_morphology1.79934237
30MP0005623_abnormal_meninges_morphology1.75170531
31MP0002138_abnormal_hepatobiliary_system1.72739794
32MP0003868_abnormal_feces_composition1.70689735
33MP0001764_abnormal_homeostasis1.69937813
34MP0000751_myopathy1.67231149
35MP0001879_abnormal_lymphatic_vessel1.66830775
36MP0000767_abnormal_smooth_muscle1.64680289
37MP0005508_abnormal_skeleton_morphology1.58532410
38MP0003091_abnormal_cell_migration1.58454422
39MP0008438_abnormal_cutaneous_collagen1.57475060
40MP0003186_abnormal_redox_activity1.56013057
41MP0005584_abnormal_enzyme/coenzyme_acti1.55617878
42MP0000749_muscle_degeneration1.45457471
43MP0003011_delayed_dark_adaptation1.40310991
44MP0009697_abnormal_copulation1.34560785
45MP0004130_abnormal_muscle_cell1.31857505
46MP0000003_abnormal_adipose_tissue1.31018653
47MP0004233_abnormal_muscle_weight1.28067174
48MP0010386_abnormal_urinary_bladder1.25241147
49MP0009643_abnormal_urine_homeostasis1.24959117
50MP0005451_abnormal_body_composition1.24687695
51MP0010030_abnormal_orbit_morphology1.23157298
52MP0005666_abnormal_adipose_tissue1.21778022
53MP0000598_abnormal_liver_morphology1.17775598
54MP0002896_abnormal_bone_mineralization1.17018109
55MP0002876_abnormal_thyroid_physiology1.14751446
56MP0000750_abnormal_muscle_regeneration1.14234629
57MP0002971_abnormal_brown_adipose1.13309856
58MP0009250_abnormal_appendicular_skeleto1.11576429
59MP0009764_decreased_sensitivity_to1.11032933
60MP0002933_joint_inflammation1.08657534
61MP0003656_abnormal_erythrocyte_physiolo1.07777288
62MP0009763_increased_sensitivity_to1.07648418
63MP0010368_abnormal_lymphatic_system1.06725595
64MP0000733_abnormal_muscle_development1.06524969
65MP0000604_amyloidosis1.03949921
66MP0005647_abnormal_sex_gland1.03551627
67MP0002254_reproductive_system_inflammat1.01342953
68MP0000759_abnormal_skeletal_muscle1.00567435
69MP0002282_abnormal_trachea_morphology1.00502736
70MP0010352_gastrointestinal_tract_polyps0.98642543
71MP0005275_abnormal_skin_tensile0.97619748
72MP0005334_abnormal_fat_pad0.97156697
73MP0001299_abnormal_eye_distance/0.96844335
74MP0001661_extended_life_span0.93355796
75MP0005165_increased_susceptibility_to0.92637496
76MP0005390_skeleton_phenotype0.92574012
77MP0003941_abnormal_skin_development0.91804580
78MP0002837_dystrophic_cardiac_calcinosis0.91786122
79MP0000343_altered_response_to0.90627869
80MP0000762_abnormal_tongue_morphology0.86805846
81MP0008469_abnormal_protein_level0.86767836
82MP0001915_intracranial_hemorrhage0.84553231
83MP0009642_abnormal_blood_homeostasis0.84299598
84MP0004858_abnormal_nervous_system0.84180167
85MP0005535_abnormal_body_temperature0.83983029
86MP0003690_abnormal_glial_cell0.83613919
87MP0002078_abnormal_glucose_homeostasis0.83260933
88MP0005376_homeostasis/metabolism_phenot0.83102622
89MP0000747_muscle_weakness0.82418404
90MP0000163_abnormal_cartilage_morphology0.81338758
91MP0001348_abnormal_lacrimal_gland0.80810057
92MP0003828_pulmonary_edema0.79608145
93MP0002128_abnormal_blood_circulation0.79495753
94MP0006036_abnormal_mitochondrial_physio0.78351387
95MP0005636_abnormal_mineral_homeostasis0.77952176
96MP0002269_muscular_atrophy0.76917194
97MP0003724_increased_susceptibility_to0.76164957
98MP0009115_abnormal_fat_cell0.75234731
99MP0009765_abnormal_xenobiotic_induced0.75086509
100MP0009384_cardiac_valve_regurgitation0.74934924
101MP0004185_abnormal_adipocyte_glucose0.72148160
102MP0005375_adipose_tissue_phenotype0.71367303
103MP0004084_abnormal_cardiac_muscle0.70260061
104MP0005408_hypopigmentation0.69965921
105MP0003385_abnormal_body_wall0.68195860
106MP0005084_abnormal_gallbladder_morpholo0.68073303
107MP0002060_abnormal_skin_morphology0.67876780
108MP0001756_abnormal_urination0.67625345
109MP0004087_abnormal_muscle_fiber0.67264653
110MP0005448_abnormal_energy_balance0.67043531
111MP0005220_abnormal_exocrine_pancreas0.65022114
112MP0003300_gastrointestinal_ulcer0.64968397
113MP0005197_abnormal_uvea_morphology0.64695137
114MP0003448_altered_tumor_morphology0.64160014
115MP0005193_abnormal_anterior_eye0.64052755
116MP0005266_abnormal_metabolism0.63146080
117MP0001614_abnormal_blood_vessel0.61807681
118MP0002970_abnormal_white_adipose0.61386682
119MP0000467_abnormal_esophagus_morphology0.61314720
120MP0005330_cardiomyopathy0.60264307
121MP0002115_abnormal_skeleton_extremities0.58939611
122MP0002113_abnormal_skeleton_development0.58826283
123MP0009053_abnormal_anal_canal0.58763827
124MP0000538_abnormal_urinary_bladder0.57918283
125MP0002932_abnormal_joint_morphology0.57460289
126MP0001175_abnormal_lung_morphology0.57129419
127MP0005388_respiratory_system_phenotype0.56891604
128MP0002133_abnormal_respiratory_system0.56891604
129MP0008775_abnormal_heart_ventricle0.56865914
130MP0000534_abnormal_ureter_morphology0.56697600
131MP0005369_muscle_phenotype0.55319941
132MP0001243_abnormal_dermal_layer0.53910208
133MP0000639_abnormal_adrenal_gland0.53493579
134MP0005395_other_phenotype0.52935888
135MP0005164_abnormal_response_to0.52486575
136MP0002168_other_aberrant_phenotype0.52230371
137MP0003329_amyloid_beta_deposits0.52011948
138MP0005023_abnormal_wound_healing0.48888175
139MP0002295_abnormal_pulmonary_circulatio0.47999371
140MP0002136_abnormal_kidney_physiology0.47606014
141MP0003436_decreased_susceptibility_to0.47176763
142MP0003959_abnormal_lean_body0.47073237
143MP0001881_abnormal_mammary_gland0.46414080
144MP0000249_abnormal_blood_vessel0.45156843
145MP0003075_altered_response_to0.45040244
146MP0008874_decreased_physiological_sensi0.45014266
147MP0004883_abnormal_blood_vessel0.44979666
148MP0005464_abnormal_platelet_physiology0.44636153
149MP0008873_increased_physiological_sensi0.44154633
150MP0000230_abnormal_systemic_arterial0.42339335
151MP0005595_abnormal_vascular_smooth0.42005975
152MP0003953_abnormal_hormone_level0.41204964
153MP0003638_abnormal_response/metabolism_0.40929771
154MP0002796_impaired_skin_barrier0.40724504
155MP0004782_abnormal_surfactant_physiolog0.37156432
156MP0006035_abnormal_mitochondrial_morpho0.37144459
157MP0003279_aneurysm0.36778296
158MP0005248_abnormal_Harderian_gland0.36655018
159MP0009672_abnormal_birth_weight0.35995574
160MP0005503_abnormal_tendon_morphology0.35189044
161MP0001542_abnormal_bone_strength0.34861544
162MP0005166_decreased_susceptibility_to0.34790637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.28117448
2Premature rupture of membranes (HP:0001788)7.10255972
3Deep venous thrombosis (HP:0002625)6.97908977
4Protrusio acetabuli (HP:0003179)6.73717883
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64503799
6Intrahepatic cholestasis (HP:0001406)6.53732539
7Xanthomatosis (HP:0000991)6.23953336
8Prolonged partial thromboplastin time (HP:0003645)6.00965987
9Hypobetalipoproteinemia (HP:0003563)5.84103785
10Hyperlipoproteinemia (HP:0010980)5.83593470
11Complement deficiency (HP:0004431)5.78566004
12Aortic dissection (HP:0002647)5.31982308
13Aortic aneurysm (HP:0004942)4.81706053
14Hypolipoproteinemia (HP:0010981)4.71834756
15Hyperammonemia (HP:0001987)4.68500607
16Epidermoid cyst (HP:0200040)4.64461880
17Vascular tortuosity (HP:0004948)4.61650433
18Hypoalphalipoproteinemia (HP:0003233)4.49229266
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.48358889
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44164726
21Abnormality of the common coagulation pathway (HP:0010990)4.43779044
22Joint hemorrhage (HP:0005261)4.41837697
23Abnormality of methionine metabolism (HP:0010901)4.37866633
24Abnormality of complement system (HP:0005339)4.28891883
25Ketosis (HP:0001946)4.24163309
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.23987787
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23939698
28Soft skin (HP:0000977)4.19367008
29Hyperglycinemia (HP:0002154)4.14936127
30Arterial tortuosity (HP:0005116)4.09017400
31Hyperglycinuria (HP:0003108)4.07714157
32Abnormality of glycine metabolism (HP:0010895)3.95861889
33Abnormality of serine family amino acid metabolism (HP:0010894)3.95861889
34Abnormality of pyrimidine metabolism (HP:0004353)3.79742675
35Atrophic scars (HP:0001075)3.69350280
36Hypoglycemic coma (HP:0001325)3.67672658
37Abnormality of the intrinsic pathway (HP:0010989)3.65343236
38Fat malabsorption (HP:0002630)3.59725792
39Follicular hyperkeratosis (HP:0007502)3.53511744
40Popliteal pterygium (HP:0009756)3.52604368
41Hypercholesterolemia (HP:0003124)3.52078332
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51277475
43Abnormality of fatty-acid metabolism (HP:0004359)3.46236484
44Vertebral compression fractures (HP:0002953)3.36645719
45Spondylolisthesis (HP:0003302)3.36551444
46Bladder diverticulum (HP:0000015)3.34417969
47Wormian bones (HP:0002645)3.31975854
48Spontaneous abortion (HP:0005268)3.31279564
49Cervical subluxation (HP:0003308)3.30585929
50Fragile skin (HP:0001030)3.26841044
51Myocardial infarction (HP:0001658)3.22796222
52Blue sclerae (HP:0000592)3.21835559
53Abnormality of dentin (HP:0010299)3.18450437
54Type 1 muscle fiber predominance (HP:0003803)3.14247089
55Abnormality of serum amino acid levels (HP:0003112)3.12073651
56Cerebral aneurysm (HP:0004944)3.11075806
57Ankle contracture (HP:0006466)3.10539947
58Skin nodule (HP:0200036)3.07999837
59Wrist flexion contracture (HP:0001239)3.04745883
60Abnormality of nucleobase metabolism (HP:0010932)3.01967786
61Dilatation of the ascending aorta (HP:0005111)3.01578571
62Systemic lupus erythematosus (HP:0002725)2.96851778
63Conjugated hyperbilirubinemia (HP:0002908)2.95699761
64Ketoacidosis (HP:0001993)2.95021355
65Hyperbilirubinemia (HP:0002904)2.92129384
66Hepatocellular carcinoma (HP:0001402)2.88953314
67Abnormal delivery (HP:0001787)2.86393897
68Steatorrhea (HP:0002570)2.77289065
69Delayed CNS myelination (HP:0002188)2.72265592
70Genu recurvatum (HP:0002816)2.69442294
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.65004759
72Osteolytic defects of the hand bones (HP:0009699)2.65004759
73Amyloidosis (HP:0011034)2.63878121
74Abnormality of purine metabolism (HP:0004352)2.63080341
75Metabolic acidosis (HP:0001942)2.62729894
76Lethargy (HP:0001254)2.62639105
77Dicarboxylic aciduria (HP:0003215)2.57327225
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57327225
79Mitral stenosis (HP:0001718)2.56928892
80Mitral valve prolapse (HP:0001634)2.56339328
81Spinal rigidity (HP:0003306)2.55175032
82Broad metatarsal (HP:0001783)2.54919353
83Shallow orbits (HP:0000586)2.54113554
84Spastic diplegia (HP:0001264)2.53377684
85Cerebral edema (HP:0002181)2.52059987
86Neonatal short-limb short stature (HP:0008921)2.50334927
87Aortic regurgitation (HP:0001659)2.48202246
88Biconcave vertebral bodies (HP:0004586)2.48077014
89Hyperextensible skin (HP:0000974)2.43727019
90Glomerulonephritis (HP:0000099)2.40109123
91Neonatal onset (HP:0003623)2.38628115
92Round ear (HP:0100830)2.36645173
93Joint stiffness (HP:0001387)2.36485113
94Pterygium (HP:0001059)2.34481600
95Abnormality of placental membranes (HP:0011409)2.33893703
96Amniotic constriction ring (HP:0009775)2.33893703
97Hydroxyprolinuria (HP:0003080)2.32793471
98Abnormality of proline metabolism (HP:0010907)2.32793471
99Vascular calcification (HP:0004934)2.32303566
100Recurrent gram-negative bacterial infections (HP:0005420)2.31565734
101Irritability (HP:0000737)2.29517568
102Aneurysm (HP:0002617)2.28870690
103Hypertriglyceridemia (HP:0002155)2.28860887
104Aortic valve stenosis (HP:0001650)2.27872789
105Hypochromic microcytic anemia (HP:0004840)2.26357674
106Cardiovascular calcification (HP:0011915)2.26147528
107Abnormal gallbladder morphology (HP:0012437)2.25899264
108Pancreatitis (HP:0001733)2.24896611
109Abnormal cartilage morphology (HP:0002763)2.24752914
110Type 2 muscle fiber atrophy (HP:0003554)2.23594239
111Gout (HP:0001997)2.23227294
112Fatigable weakness (HP:0003473)2.23061343
113Abnormality of the neuromuscular junction (HP:0003398)2.23061343
114Mildly elevated creatine phosphokinase (HP:0008180)2.22354757
115Gingival bleeding (HP:0000225)2.21582720
116Cholelithiasis (HP:0001081)2.20772745
117Abnormality of the acetabulum (HP:0003170)2.19533296
118Brushfield spots (HP:0001088)2.19331795
119Joint laxity (HP:0001388)2.19286209
120Striae distensae (HP:0001065)2.17861393
121Aplasia of the musculature (HP:0100854)2.16308477
122Elbow flexion contracture (HP:0002987)2.16061298
123Mesomelia (HP:0003027)2.13789850
124Ovoid vertebral bodies (HP:0003300)2.13616421
125Ectopia lentis (HP:0001083)2.12193868
126Overgrowth (HP:0001548)2.11348839
127Slender build (HP:0001533)2.10208904
128Hypoglycemic seizures (HP:0002173)2.10147714
129Vomiting (HP:0002013)2.10027611
130Abnormal gallbladder physiology (HP:0012438)2.09858301
131Cholecystitis (HP:0001082)2.09858301
132Hemorrhage of the eye (HP:0011885)2.06812551
133Enlarged kidneys (HP:0000105)2.05071010
134Thrombophlebitis (HP:0004418)2.04765247
135Increased variability in muscle fiber diameter (HP:0003557)2.04149171
136Ulnar bowing (HP:0003031)2.04027293
137Generalized amyotrophy (HP:0003700)2.03710161
138Sensorimotor neuropathy (HP:0007141)2.03201127
139Mitral regurgitation (HP:0001653)2.02134248
140Esophageal varix (HP:0002040)2.02079267
141Acanthocytosis (HP:0001927)1.99676901
142Ulnar deviation of the wrist (HP:0003049)1.99509535
143Muscle fiber atrophy (HP:0100295)1.98497622
144Opisthotonus (HP:0002179)1.97990657
145Nonimmune hydrops fetalis (HP:0001790)1.97532124
146Menorrhagia (HP:0000132)1.93805799
147Bowel diverticulosis (HP:0005222)1.93686907
148Generalized aminoaciduria (HP:0002909)1.93547066
149Delayed gross motor development (HP:0002194)1.91810086
150Wide anterior fontanel (HP:0000260)1.90213741
151Thin ribs (HP:0000883)1.87777658
152Late onset (HP:0003584)1.87055600
153Glucose intolerance (HP:0000833)1.86080521
154Weak cry (HP:0001612)1.85919403
155Hyperglycemia (HP:0003074)1.85908618
156Nephritis (HP:0000123)1.85833153
157Abnormality of iron homeostasis (HP:0011031)1.85323654
158Malnutrition (HP:0004395)1.84612208
159Reduced subcutaneous adipose tissue (HP:0003758)1.84395914
160Gowers sign (HP:0003391)1.84147004
161Abnormality of the gallbladder (HP:0005264)1.82803305
162Absent frontal sinuses (HP:0002688)1.82388738
163Coronal craniosynostosis (HP:0004440)1.82184485
164Pulmonary artery stenosis (HP:0004415)1.79923483
165Coxa vara (HP:0002812)1.78971853
166Delayed cranial suture closure (HP:0000270)1.78765054
167Elevated hepatic transaminases (HP:0002910)1.78712683
168Spinal cord compression (HP:0002176)1.78294795
169Venous insufficiency (HP:0005293)1.77985776
170Venous abnormality (HP:0002624)1.77891558
171Short nail (HP:0001799)1.77356753
172Alkalosis (HP:0001948)1.77006622
173Osteoarthritis (HP:0002758)1.76986529
174Abnormality of transition element cation homeostasis (HP:0011030)1.76574092
175Metaphyseal dysplasia (HP:0100255)1.76384057
176Delayed closure of the anterior fontanelle (HP:0001476)1.75587508
177Peritonitis (HP:0002586)1.73590916
178Back pain (HP:0003418)1.72694262
179Renal cortical cysts (HP:0000803)1.71575288
180Increased purine levels (HP:0004368)1.67945280
181Hyperuricemia (HP:0002149)1.67945280
182Nausea (HP:0002018)1.67059854
183Abnormality of the Achilles tendon (HP:0005109)1.66014434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.86049373
2MUSK5.71336974
3ERN15.09647501
4SIK14.34820272
5FGFR44.03526044
6TRIB33.16571683
7ERBB42.83175190
8MAP3K122.63353716
9LIMK12.56679628
10INSRR2.48083296
11MST1R2.24560620
12TESK12.23273999
13PAK42.05505106
14PKN21.91809062
15MAP2K41.85528188
16TTN1.84271981
17CAMK1D1.78595064
18LATS11.73480122
19TAOK31.71880067
20MAPK111.71322572
21MOS1.62672361
22NEK91.60856930
23FRK1.57645141
24FLT31.54092792
25ABL21.53645041
26PIK3CG1.51829708
27ILK1.48912664
28NTRK11.46917019
29TRPM71.44367951
30TYK21.31716878
31EPHA31.31213305
32FGFR21.31071805
33PTK61.26975536
34PRKAA21.25042355
35PDGFRB1.22949509
36PRKD21.19974464
37RIPK11.14695541
38CDC42BPA1.13859218
39EPHA21.13524956
40KDR1.13478063
41MAPKAPK31.10986066
42JAK21.10549432
43LATS21.09821262
44MET1.09411246
45TBK11.08063159
46JAK11.07805866
47DAPK31.05307010
48PIM21.03431382
49ARAF1.03073547
50MAP2K30.99075027
51ROCK10.98510751
52STK380.97251647
53DAPK20.96345708
54MAP3K30.95847614
55CDK60.94555187
56PDK40.92848920
57PDK30.92848920
58CAMK1G0.91582523
59ERBB20.91416579
60TGFBR20.90524287
61EPHB10.90291094
62CDK80.90227628
63STK38L0.90209577
64LMTK20.90111995
65FGFR30.89200875
66PINK10.89118241
67ADRBK10.89064660
68MAP2K10.87577254
69PDGFRA0.86383200
70MAPK40.82573295
71MAP3K70.80509234
72TIE10.77046912
73MAPK120.76851041
74EPHB20.76272146
75PRKACG0.75769735
76PRKCZ0.75266636
77ROCK20.74574547
78PIK3CA0.74124895
79GSK3A0.68287305
80CAMK2G0.67126324
81GRK60.66132360
82MAP3K110.65901959
83NEK10.63950775
84MYLK0.63813177
85GRK10.62774256
86PTK20.62555789
87MAP3K140.62051188
88PRKAA10.61656559
89CLK10.61525359
90IRAK30.58977294
91PDPK10.58012408
92IGF1R0.57898633
93EIF2AK30.57196179
94PRKG20.57153946
95NME20.56264047
96CSK0.56234127
97STK240.56211469
98MELK0.55682726
99PDK20.53006602
100FER0.52604500
101MAP3K60.51780803
102DMPK0.51581570
103EIF2AK10.51170087
104DDR20.49722329
105DYRK1B0.48884188
106TAOK20.48716115
107MAP3K100.48624449
108RET0.48423279
109PRKCE0.47515777
110MTOR0.47405399
111BMX0.47360957
112NLK0.45486640
113ZAP700.45024945
114CSF1R0.44249308
115PAK60.43288126
116MAP3K50.43020336
117MAPK70.42104982
118MAP2K60.41601117
119IKBKE0.40440811
120PAK30.40243913
121IRAK10.40048941
122AKT30.37162156
123PTK2B0.36656138
124SGK30.36344317
125PRKD30.36204898
126STK30.35318685
127CAMK2D0.35258249
128PLK20.34764218
129PRKCH0.33929825
130JAK30.33760282
131MAP3K20.33593725
132MAPK150.32787022
133PAK10.32207059
134PKN10.31930343
135RPS6KA20.31909658
136MAPKAPK20.31802592
137PAK20.31521761
138FGFR10.31496330
139EGFR0.30470735
140CSNK1G10.30383866
141STK160.28972542
142PDK10.28496472
143CDK40.27719805
144GRK50.27711826
145KIT0.27706731
146ABL10.27110733
147PRKCQ0.25353440
148PRKD10.24624819
149PRKCG0.22764802
150INSR0.22488286

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42778918
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59428560
3Nitrogen metabolism_Homo sapiens_hsa009103.53749309
4ECM-receptor interaction_Homo sapiens_hsa045123.27738823
5Arginine biosynthesis_Homo sapiens_hsa002203.26971600
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10429603
7Complement and coagulation cascades_Homo sapiens_hsa046102.80370014
8Tryptophan metabolism_Homo sapiens_hsa003802.62754841
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54774440
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53501535
11Fatty acid degradation_Homo sapiens_hsa000712.49243259
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47066445
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40935742
14PPAR signaling pathway_Homo sapiens_hsa033202.16892687
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12490940
16Propanoate metabolism_Homo sapiens_hsa006402.11094543
17Focal adhesion_Homo sapiens_hsa045102.11085566
18Peroxisome_Homo sapiens_hsa041462.10663287
19Caffeine metabolism_Homo sapiens_hsa002322.10408924
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09972926
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04470363
22Butanoate metabolism_Homo sapiens_hsa006501.95865275
23Chemical carcinogenesis_Homo sapiens_hsa052041.89321260
24Fatty acid metabolism_Homo sapiens_hsa012121.86069867
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85663763
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.82297610
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80518897
28Staphylococcus aureus infection_Homo sapiens_hsa051501.79539389
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78219162
30Phenylalanine metabolism_Homo sapiens_hsa003601.76085931
31Histidine metabolism_Homo sapiens_hsa003401.73148776
32beta-Alanine metabolism_Homo sapiens_hsa004101.70330777
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67112222
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63472291
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63419738
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.60936443
37Retinol metabolism_Homo sapiens_hsa008301.54694884
38Tyrosine metabolism_Homo sapiens_hsa003501.50669438
39Selenocompound metabolism_Homo sapiens_hsa004501.49784592
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.43683240
41Pyruvate metabolism_Homo sapiens_hsa006201.42335691
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34854342
43Biosynthesis of amino acids_Homo sapiens_hsa012301.32994147
44Bile secretion_Homo sapiens_hsa049761.32308736
45Dilated cardiomyopathy_Homo sapiens_hsa054141.32303407
46Other glycan degradation_Homo sapiens_hsa005111.30319604
47Sulfur metabolism_Homo sapiens_hsa009201.29996451
48Starch and sucrose metabolism_Homo sapiens_hsa005001.24952846
49Carbon metabolism_Homo sapiens_hsa012001.22096893
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21879954
51Proteoglycans in cancer_Homo sapiens_hsa052051.21605617
52Fatty acid elongation_Homo sapiens_hsa000621.19504873
53Fat digestion and absorption_Homo sapiens_hsa049751.18587081
54Folate biosynthesis_Homo sapiens_hsa007901.17285317
55Mineral absorption_Homo sapiens_hsa049781.15778142
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12291002
57Steroid biosynthesis_Homo sapiens_hsa001001.02471343
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02249025
59ABC transporters_Homo sapiens_hsa020101.01909192
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97345754
61Sulfur relay system_Homo sapiens_hsa041220.93427944
62Arginine and proline metabolism_Homo sapiens_hsa003300.92735191
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89353316
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89118453
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88130083
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86514548
67Glycerolipid metabolism_Homo sapiens_hsa005610.83792785
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80563520
69Vitamin B6 metabolism_Homo sapiens_hsa007500.80430269
70Fatty acid biosynthesis_Homo sapiens_hsa000610.80334903
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.80323521
72N-Glycan biosynthesis_Homo sapiens_hsa005100.79590007
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77829099
74TGF-beta signaling pathway_Homo sapiens_hsa043500.76671100
75Adherens junction_Homo sapiens_hsa045200.74958646
76Vitamin digestion and absorption_Homo sapiens_hsa049770.72620975
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.72146018
78Melanoma_Homo sapiens_hsa052180.72078019
79Lysine degradation_Homo sapiens_hsa003100.71048858
80Small cell lung cancer_Homo sapiens_hsa052220.70023922
81Glutathione metabolism_Homo sapiens_hsa004800.69162843
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68128024
83Sphingolipid metabolism_Homo sapiens_hsa006000.66366055
84* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64277258
85Pentose phosphate pathway_Homo sapiens_hsa000300.64086947
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60658482
87One carbon pool by folate_Homo sapiens_hsa006700.57905917
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49159560
89Protein export_Homo sapiens_hsa030600.45617178
90Prion diseases_Homo sapiens_hsa050200.44870470
91* Metabolic pathways_Homo sapiens_hsa011000.44639461
92Circadian rhythm_Homo sapiens_hsa047100.44526081
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42756800
94Lysosome_Homo sapiens_hsa041420.41883811
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.40963148
96Vibrio cholerae infection_Homo sapiens_hsa051100.39007939
97Tight junction_Homo sapiens_hsa045300.34835475
98p53 signaling pathway_Homo sapiens_hsa041150.33394376
99Pathways in cancer_Homo sapiens_hsa052000.32970319
100Bladder cancer_Homo sapiens_hsa052190.32075788
101Insulin resistance_Homo sapiens_hsa049310.32056583
102Fructose and mannose metabolism_Homo sapiens_hsa000510.29619961
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29377101
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24760323
105Linoleic acid metabolism_Homo sapiens_hsa005910.23600805
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22492474
107Galactose metabolism_Homo sapiens_hsa000520.22361494
108AMPK signaling pathway_Homo sapiens_hsa041520.20684144
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.19589766
110Glucagon signaling pathway_Homo sapiens_hsa049220.16882195
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08715366
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03160734
113Pertussis_Homo sapiens_hsa05133-0.2033997
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1976116
115Malaria_Homo sapiens_hsa05144-0.1934428
116Hepatitis C_Homo sapiens_hsa05160-0.1721582
117Regulation of autophagy_Homo sapiens_hsa04140-0.1688507
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1688033
119Protein digestion and absorption_Homo sapiens_hsa04974-0.1625451
120African trypanosomiasis_Homo sapiens_hsa05143-0.1578502
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1513696
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1468512
123Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1422050
124Amoebiasis_Homo sapiens_hsa05146-0.1087436
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1057278
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0924989
127Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0847811
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0764186
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0543907
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0274129
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0106790
132Insulin signaling pathway_Homo sapiens_hsa04910-0.0094464

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