NNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.54859676
2cardiac myofibril assembly (GO:0055003)6.53319256
3* tricarboxylic acid cycle (GO:0006099)5.77788723
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.71698296
5lysine catabolic process (GO:0006554)5.70111881
6lysine metabolic process (GO:0006553)5.70111881
7myofibril assembly (GO:0030239)5.63335792
8skeletal muscle contraction (GO:0003009)5.58921967
92-oxoglutarate metabolic process (GO:0006103)5.49084588
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.47385574
11regulation of cell communication by electrical coupling (GO:0010649)5.41090653
12negative regulation of potassium ion transmembrane transport (GO:1901380)5.28424031
13carnitine shuttle (GO:0006853)5.24496011
14actin filament-based movement (GO:0030048)5.20992884
15fatty acid transmembrane transport (GO:1902001)4.97335876
16aspartate family amino acid catabolic process (GO:0009068)4.87894801
17cardiac muscle contraction (GO:0060048)4.87448785
18actin-myosin filament sliding (GO:0033275)4.83648737
19muscle filament sliding (GO:0030049)4.83648737
20fatty acid beta-oxidation (GO:0006635)4.82582022
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.80682676
22cardiac muscle cell development (GO:0055013)4.70173450
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.62669577
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.62013720
25glyoxylate metabolic process (GO:0046487)4.59196912
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.54801973
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.47860456
28cardiac muscle hypertrophy (GO:0003300)4.47636356
29response to inactivity (GO:0014854)4.45031144
30cardiac cell development (GO:0055006)4.40829269
31regulation of sarcomere organization (GO:0060297)4.40480573
32response to muscle activity (GO:0014850)4.35755656
33regulation of relaxation of muscle (GO:1901077)4.34476878
34cellular ketone body metabolic process (GO:0046950)4.29262366
35positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.26153449
36heart trabecula formation (GO:0060347)4.25148341
37regulation of actin filament-based movement (GO:1903115)4.25137638
38ventricular cardiac muscle cell action potential (GO:0086005)4.22743112
39striated muscle hypertrophy (GO:0014897)4.21693176
40fatty acid oxidation (GO:0019395)4.20064998
41cardiac muscle tissue morphogenesis (GO:0055008)4.17440313
42tricarboxylic acid metabolic process (GO:0072350)4.16160035
43carnitine transmembrane transport (GO:1902603)4.14620056
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.14340152
45fatty acid catabolic process (GO:0009062)4.11579742
46heart contraction (GO:0060047)4.11466034
47heart process (GO:0003015)4.11466034
48muscle contraction (GO:0006936)4.11287842
49adult heart development (GO:0007512)4.11121455
50actomyosin structure organization (GO:0031032)4.11028458
51lipid oxidation (GO:0034440)4.10693226
52amino-acid betaine transport (GO:0015838)4.08318767
53carnitine transport (GO:0015879)4.08318767
54regulation of acyl-CoA biosynthetic process (GO:0050812)4.07381773
55ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.07345355
56carnitine metabolic process (GO:0009437)4.06491204
57plasma membrane repair (GO:0001778)4.03639666
58actin-mediated cell contraction (GO:0070252)4.03477829
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00773071
60skeletal muscle adaptation (GO:0043501)3.98395013
61amino-acid betaine metabolic process (GO:0006577)3.96275281
62kynurenine metabolic process (GO:0070189)3.95454408
63regulation of skeletal muscle contraction (GO:0014819)3.94886003
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93812610
65oxaloacetate metabolic process (GO:0006107)3.92221990
66branched-chain amino acid catabolic process (GO:0009083)3.92154928
67short-chain fatty acid metabolic process (GO:0046459)3.91107144
68acetyl-CoA metabolic process (GO:0006084)3.84960231
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.84283496
70regulation of fatty acid oxidation (GO:0046320)3.82905467
71muscle hypertrophy (GO:0014896)3.79492540
72valine metabolic process (GO:0006573)3.79081970
73NADH metabolic process (GO:0006734)3.78425827
74regulation of sequestering of triglyceride (GO:0010889)3.77248509
75response to epinephrine (GO:0071871)3.76505101
76monocarboxylic acid catabolic process (GO:0072329)3.73674449
77ketone body metabolic process (GO:1902224)3.73625874
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73209468
79L-phenylalanine metabolic process (GO:0006558)3.73209468
80muscle system process (GO:0003012)3.73081603
81muscle tissue morphogenesis (GO:0060415)3.72547983
82branched-chain amino acid metabolic process (GO:0009081)3.71524810
83regulation of cofactor metabolic process (GO:0051193)3.70907743
84regulation of coenzyme metabolic process (GO:0051196)3.70907743
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.70637962
86L-phenylalanine catabolic process (GO:0006559)3.70371882
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.70371882
88glycogen catabolic process (GO:0005980)3.68028774
89regulation of calcium ion transmembrane transporter activity (GO:1901019)3.64642476
90regulation of calcium ion transmembrane transport (GO:1903169)3.64642476
91relaxation of cardiac muscle (GO:0055119)3.64627042
92striated muscle contraction (GO:0006941)3.62031867
93succinate metabolic process (GO:0006105)3.60060590
94alpha-linolenic acid metabolic process (GO:0036109)3.52301484
95regulation of striated muscle contraction (GO:0006942)3.46251243
96striated muscle adaptation (GO:0014888)3.46054911
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.43882460
98oxidative phosphorylation (GO:0006119)3.42488906
99dicarboxylic acid biosynthetic process (GO:0043650)3.42101497
100quaternary ammonium group transport (GO:0015697)3.38962321
101glucan catabolic process (GO:0009251)3.37888319
102aromatic amino acid family catabolic process (GO:0009074)3.33888905
103sarcoplasmic reticulum calcium ion transport (GO:0070296)3.33521124
104cardiac muscle hypertrophy in response to stress (GO:0014898)3.33308772
105muscle hypertrophy in response to stress (GO:0003299)3.33308772
106cardiac muscle adaptation (GO:0014887)3.33308772
107regulation of cardiac muscle cell contraction (GO:0086004)3.32970850
108regulation of the force of heart contraction (GO:0002026)3.32848280
109positive regulation of fatty acid oxidation (GO:0046321)3.32304439
110creatine metabolic process (GO:0006600)3.31944419
111regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26366232
1124-hydroxyproline metabolic process (GO:0019471)3.26050063
113regulation of sulfur metabolic process (GO:0042762)3.24755569
114relaxation of muscle (GO:0090075)3.24611238
115muscle fiber development (GO:0048747)3.24445286
116cell communication involved in cardiac conduction (GO:0086065)3.22045781
117ethanol oxidation (GO:0006069)3.20521964
118triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20512305
119cellular polysaccharide catabolic process (GO:0044247)3.20141002
120positive regulation of cation channel activity (GO:2001259)3.19995293
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17037199
122myotube cell development (GO:0014904)3.16661079
123regulation of triglyceride catabolic process (GO:0010896)3.15105039
124cellular response to epinephrine stimulus (GO:0071872)3.14533635
125phospholipid homeostasis (GO:0055091)3.12603687
126biotin metabolic process (GO:0006768)3.11523935
127skeletal muscle fiber development (GO:0048741)3.11266397
128regulation of cardiac muscle contraction (GO:0055117)3.10854024
129muscle cell cellular homeostasis (GO:0046716)3.09005987
130negative regulation of calcium ion transmembrane transport (GO:1903170)3.08276511
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.08276511
132regulation of ATPase activity (GO:0043462)3.04177746
133regulation of ATP catabolic process (GO:1903289)3.04177746
134regulation of membrane repolarization (GO:0060306)3.01505775
135skeletal muscle tissue development (GO:0007519)3.01146191
136glycogen biosynthetic process (GO:0005978)2.99667813
137glucan biosynthetic process (GO:0009250)2.99667813
138skeletal muscle tissue regeneration (GO:0043403)2.98078506
139polysaccharide catabolic process (GO:0000272)2.94243341
140striated muscle atrophy (GO:0014891)2.91633476
141striated muscle cell development (GO:0055002)2.90818185
142response to caffeine (GO:0031000)2.89259324
143regulation of muscle system process (GO:0090257)2.87929411
144regulation of muscle contraction (GO:0006937)2.83120884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.60974257
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.77717483
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.77559687
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.30182467
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.77127263
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.26605094
7EZH2_22144423_ChIP-Seq_EOC_Human4.03663467
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.73579022
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.57002927
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53192142
11EP300_21415370_ChIP-Seq_HL-1_Mouse3.40740448
12* GBX2_23144817_ChIP-Seq_PC3_Human3.21999362
13* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.06890267
14* TBX20_22328084_ChIP-Seq_HEART_Mouse3.06831551
15* TBX20_22080862_ChIP-Seq_HEART_Mouse3.06831551
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73940993
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.67891924
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51585285
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46723234
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34741312
21CLOCK_20551151_ChIP-Seq_293T_Human2.33069486
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23177179
23MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.22427487
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16272207
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13091754
26GATA1_22025678_ChIP-Seq_K562_Human2.12513311
27IGF1R_20145208_ChIP-Seq_DFB_Human2.10455793
28ESR1_20079471_ChIP-ChIP_T-47D_Human2.09168386
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07550074
30GATA4_21415370_ChIP-Seq_HL-1_Mouse1.97431988
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95818605
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89724993
33SMAD4_21799915_ChIP-Seq_A2780_Human1.84256552
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81934774
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81108889
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76746772
37* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72439338
38NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.72245432
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69986011
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68806846
41TAF15_26573619_Chip-Seq_HEK293_Human1.68528878
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67539015
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66923637
44FUS_26573619_Chip-Seq_HEK293_Human1.66764230
45AR_21572438_ChIP-Seq_LNCaP_Human1.65664339
46VDR_22108803_ChIP-Seq_LS180_Human1.64978744
47* STAT3_23295773_ChIP-Seq_U87_Human1.61007193
48ER_23166858_ChIP-Seq_MCF-7_Human1.60831757
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59710848
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.59695467
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59157666
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58800928
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.54185678
54* TCF4_23295773_ChIP-Seq_U87_Human1.53168089
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.52694544
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52374037
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50942339
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50091058
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49607556
60ZNF263_19887448_ChIP-Seq_K562_Human1.49135957
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48282078
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39507988
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.39193044
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38930796
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38610212
66DROSHA_22980978_ChIP-Seq_HELA_Human1.36924911
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.34600090
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34522696
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.32328603
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32216185
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31099476
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27909240
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.26493103
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24407470
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23870879
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.23566299
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22638625
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22516566
79P53_22387025_ChIP-Seq_ESCs_Mouse1.21927106
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21508792
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.21261599
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20408556
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18812114
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18136634
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17531814
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17208084
87P300_19829295_ChIP-Seq_ESCs_Human1.16226922
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14957485
89* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14890733
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14803901
91CBP_20019798_ChIP-Seq_JUKART_Human1.14803901
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14403112
93HNF4A_19822575_ChIP-Seq_HepG2_Human1.14256933
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12047485
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11327844
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10396813
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10080985
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09807949
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09278263
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09175689
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08414072
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07916985
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07496563
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06699739
105AR_25329375_ChIP-Seq_VCAP_Human1.06528257
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05744966
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04655542
108TBL1_22424771_ChIP-Seq_293T_Human1.04268835
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04009782
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.03999596
111* CBX2_27304074_Chip-Seq_ESCs_Mouse1.03719416
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.03536503
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02941254
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02812769
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02666304
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02567297
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.02510297
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02107178
119TP53_16413492_ChIP-PET_HCT116_Human1.01993325
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01421869
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00129656
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96256312
123* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95943126
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94432380
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92684145
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92591055
127GATA1_19941826_ChIP-Seq_K562_Human0.91944729
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90791596
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86910466
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85942401
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.85439472
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84071841
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83381958
134GATA2_19941826_ChIP-Seq_K562_Human0.82024141
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81738525
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.78399052
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.78333983
138GATA4_25053715_ChIP-Seq_YYC3_Human0.76826982
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75990606
140LXR_22292898_ChIP-Seq_THP-1_Human0.72804158
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72482744
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70981607
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70929544
144* ISL1_27105846_Chip-Seq_CPCs_Mouse0.69840036
145HTT_18923047_ChIP-ChIP_STHdh_Human0.69085135
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68101159
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.67192655
148SPI1_20517297_ChIP-Seq_HL60_Human0.67010888
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66912884
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66912884
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.66408547
152BP1_19119308_ChIP-ChIP_Hs578T_Human0.66108703
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.65957346
154SRF_21415370_ChIP-Seq_HL-1_Mouse0.65829613
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65021150
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64376887
157ATF3_27146783_Chip-Seq_COLON_Human0.64023892
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.63114728
159CJUN_26792858_Chip-Seq_BT549_Human0.62854860
160RACK7_27058665_Chip-Seq_MCF-7_Human0.61559641
161CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61523698
162WT1_19549856_ChIP-ChIP_CCG9911_Human0.60443635
163GATA6_25053715_ChIP-Seq_YYC3_Human0.60279611
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.59999847
165RBPJ_22232070_ChIP-Seq_NCS_Mouse0.59172230
166HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.59061837
167* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.57994290
168GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57762017
169CBP_21632823_ChIP-Seq_H3396_Human0.57504249
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57410326
171ELK3_25401928_ChIP-Seq_HUVEC_Human0.56793970
172CEBPB_22108803_ChIP-Seq_LS180_Human0.56675560
173TBX5_21415370_ChIP-Seq_HL-1_Mouse0.56472711
174SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55895124
175BCAT_22108803_ChIP-Seq_LS180_Human0.55567616
176SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.55223971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.74742106
2MP0004084_abnormal_cardiac_muscle4.83733740
3MP0003646_muscle_fatigue4.44419885
4MP0004215_abnormal_myocardial_fiber3.93643337
5MP0000751_myopathy3.77027301
6MP0004036_abnormal_muscle_relaxation3.51492503
7MP0005330_cardiomyopathy3.45866797
8MP0005360_urolithiasis3.34846204
9MP0002139_abnormal_hepatobiliary_system3.32966542
10MP0005085_abnormal_gallbladder_physiolo3.04701805
11MP0000749_muscle_degeneration2.91538416
12MP0005365_abnormal_bile_salt2.71839231
13MP0002972_abnormal_cardiac_muscle2.64731088
14MP0000372_irregular_coat_pigmentation2.63611105
15MP0004087_abnormal_muscle_fiber2.56064865
16MP0008775_abnormal_heart_ventricle2.51335086
17MP0004130_abnormal_muscle_cell2.49827897
18MP0003806_abnormal_nucleotide_metabolis2.37483931
19MP0010630_abnormal_cardiac_muscle2.35382061
20MP0003137_abnormal_impulse_conducting2.30170482
21MP0001544_abnormal_cardiovascular_syste2.29485655
22MP0005385_cardiovascular_system_phenoty2.29485655
23MP0005620_abnormal_muscle_contractility2.16629117
24MP0006138_congestive_heart_failure2.07568054
25MP0000750_abnormal_muscle_regeneration2.03477293
26MP0004484_altered_response_of2.00787612
27MP0002269_muscular_atrophy1.98489901
28MP0008875_abnormal_xenobiotic_pharmacok1.95453946
29MP0006036_abnormal_mitochondrial_physio1.92095855
30MP0003252_abnormal_bile_duct1.92054219
31MP0002106_abnormal_muscle_physiology1.86838004
32MP0005171_absent_coat_pigmentation1.81096650
33MP0003828_pulmonary_edema1.79523226
34MP0003195_calcinosis1.76339146
35MP0003221_abnormal_cardiomyocyte_apopto1.71940605
36MP0004085_abnormal_heartbeat1.68662222
37MP0005332_abnormal_amino_acid1.66746174
38MP0009840_abnormal_foam_cell1.57101687
39MP0000013_abnormal_adipose_tissue1.54409704
40MP0005369_muscle_phenotype1.51265140
41MP0000747_muscle_weakness1.51120219
42MP0005083_abnormal_biliary_tract1.46604840
43MP0010329_abnormal_lipoprotein_level1.45151605
44MP0001661_extended_life_span1.43023111
45MP0005666_abnormal_adipose_tissue1.41581309
46MP0000759_abnormal_skeletal_muscle1.41344708
47MP0002127_abnormal_cardiovascular_syste1.38187983
48MP0010368_abnormal_lymphatic_system1.36978808
49MP0005319_abnormal_enzyme/_coenzyme1.36569543
50MP0000569_abnormal_digit_pigmentation1.32725826
51MP0005670_abnormal_white_adipose1.31045513
52MP0003567_abnormal_fetal_cardiomyocyte1.29193932
53MP0004233_abnormal_muscle_weight1.28567368
54MP0004147_increased_porphyrin_level1.27665963
55MP0004270_analgesia1.23503307
56MP0004145_abnormal_muscle_electrophysio1.22202905
57MP0003705_abnormal_hypodermis_morpholog1.17831023
58MP0000343_altered_response_to1.17516332
59MP0003279_aneurysm1.16765010
60MP0000733_abnormal_muscle_development1.16379167
61MP0002118_abnormal_lipid_homeostasis1.14885440
62MP0005408_hypopigmentation1.14129481
63MP0001666_abnormal_nutrient_absorption1.08615452
64MP0004043_abnormal_pH_regulation1.08469591
65MP0005451_abnormal_body_composition1.07784548
66MP0003950_abnormal_plasma_membrane1.05699623
67MP0000266_abnormal_heart_morphology1.05206986
68MP0004510_myositis1.04479230
69MP0006035_abnormal_mitochondrial_morpho1.03067967
70MP0000609_abnormal_liver_physiology1.02902643
71MP0005165_increased_susceptibility_to1.02325842
72MP0009643_abnormal_urine_homeostasis1.01092828
73MP0009780_abnormal_chondrocyte_physiolo0.98724220
74MP0002332_abnormal_exercise_endurance0.98484269
75MP0002877_abnormal_melanocyte_morpholog0.94654235
76MP0005266_abnormal_metabolism0.92699745
77MP0003191_abnormal_cellular_cholesterol0.92287443
78MP0005584_abnormal_enzyme/coenzyme_acti0.90785660
79MP0008438_abnormal_cutaneous_collagen0.89314671
80MP0000230_abnormal_systemic_arterial0.88551750
81MP0002128_abnormal_blood_circulation0.86970514
82MP0002822_catalepsy0.86868686
83MP0003045_fibrosis0.86023753
84MP0005375_adipose_tissue_phenotype0.85466553
85MP0002638_abnormal_pupillary_reflex0.84779877
86* MP0002078_abnormal_glucose_homeostasis0.81823500
87MP0005386_behavior/neurological_phenoty0.80341970
88MP0004924_abnormal_behavior0.80341970
89MP0002876_abnormal_thyroid_physiology0.75346549
90MP0003136_yellow_coat_color0.75017387
91MP0009046_muscle_twitch0.74319677
92MP0002971_abnormal_brown_adipose0.74163770
93MP0004185_abnormal_adipocyte_glucose0.73877462
94MP0002138_abnormal_hepatobiliary_system0.73554289
95MP0003566_abnormal_cell_adhesion0.73409693
96MP0002234_abnormal_pharynx_morphology0.71499844
97MP0009384_cardiac_valve_regurgitation0.71304105
98MP0002108_abnormal_muscle_morphology0.70216050
99MP0003186_abnormal_redox_activity0.69611176
100MP0003868_abnormal_feces_composition0.68549945
101MP0000371_diluted_coat_color0.67180366
102MP0002009_preneoplasia0.66646029
103MP0001879_abnormal_lymphatic_vessel0.66488612
104MP0000767_abnormal_smooth_muscle0.66099572
105MP0000015_abnormal_ear_pigmentation0.63548589
106MP0009697_abnormal_copulation0.62891844
107MP0000598_abnormal_liver_morphology0.62548501
108MP0008569_lethality_at_weaning0.61068746
109MP0008961_abnormal_basal_metabolism0.58004424
110MP0004019_abnormal_vitamin_homeostasis0.57023272
111MP0004142_abnormal_muscle_tone0.55904407
112MP0001764_abnormal_homeostasis0.54524260
113MP0009763_increased_sensitivity_to0.54464678
114MP0005334_abnormal_fat_pad0.54207705
115MP0005253_abnormal_eye_physiology0.53444072
116MP0003656_abnormal_erythrocyte_physiolo0.51132971
117MP0002272_abnormal_nervous_system0.51001768
118MP0005645_abnormal_hypothalamus_physiol0.50721479
119MP0009745_abnormal_behavioral_response0.50657685
120MP0009642_abnormal_blood_homeostasis0.50028607
121MP0006276_abnormal_autonomic_nervous0.49283097
122MP0005376_homeostasis/metabolism_phenot0.48641481
123MP0002064_seizures0.48511061
124MP0004134_abnormal_chest_morphology0.47583724
125MP0005535_abnormal_body_temperature0.47484087
126MP0000003_abnormal_adipose_tissue0.46595711
127MP0006054_spinal_hemorrhage0.44976015
128MP0001765_abnormal_ion_homeostasis0.44463175
129MP0005636_abnormal_mineral_homeostasis0.43835376
130MP0005409_darkened_coat_color0.43155663
131MP0003959_abnormal_lean_body0.43085060
132MP0001984_abnormal_olfaction0.43075652
133MP0005551_abnormal_eye_electrophysiolog0.42495378
134MP0002067_abnormal_sensory_capabilities0.42232984
135MP0002095_abnormal_skin_pigmentation0.41740299
136MP0004272_abnormal_basement_membrane0.41608045
137MP0001756_abnormal_urination0.41301149
138MP0005187_abnormal_penis_morphology0.40779545

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.68765843
2Nemaline bodies (HP:0003798)8.52767120
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.40712622
4Sudden death (HP:0001699)6.47435361
5Ventricular tachycardia (HP:0004756)5.78855847
6Atrial fibrillation (HP:0005110)4.98650323
7Calf muscle hypertrophy (HP:0008981)4.78013111
8Myoglobinuria (HP:0002913)4.75871535
9Exercise-induced muscle cramps (HP:0003710)4.74724713
10Primary atrial arrhythmia (HP:0001692)4.58371994
11Hypoglycemic coma (HP:0001325)4.54389421
12Distal arthrogryposis (HP:0005684)4.54087556
13Lipoatrophy (HP:0100578)4.53208765
14Exercise-induced myalgia (HP:0003738)4.45561800
15Right ventricular cardiomyopathy (HP:0011663)4.44093516
16Supraventricular tachycardia (HP:0004755)4.42562865
17Supraventricular arrhythmia (HP:0005115)4.33292987
18Muscle hypertrophy of the lower extremities (HP:0008968)4.27504034
19Ketoacidosis (HP:0001993)4.19821627
20Muscle fiber splitting (HP:0003555)4.10260640
21Abnormality of fatty-acid metabolism (HP:0004359)4.03596631
22Abnormality of the left ventricular outflow tract (HP:0011103)3.99293960
23Subaortic stenosis (HP:0001682)3.99293960
24Syncope (HP:0001279)3.99203406
25Rimmed vacuoles (HP:0003805)3.98937974
26Dilated cardiomyopathy (HP:0001644)3.98689508
27Abnormality of the calf musculature (HP:0001430)3.98664237
28Palpitations (HP:0001962)3.94934292
29Ketosis (HP:0001946)3.87367690
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.81223790
31Neck muscle weakness (HP:0000467)3.80448078
32Asymmetric septal hypertrophy (HP:0001670)3.70099058
33Rhabdomyolysis (HP:0003201)3.68618517
34Hyporeflexia of lower limbs (HP:0002600)3.63962627
35Dicarboxylic aciduria (HP:0003215)3.55176917
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.55176917
37Frequent falls (HP:0002359)3.53119974
38Myopathic facies (HP:0002058)3.50840739
39Round ear (HP:0100830)3.50061730
40Hyperammonemia (HP:0001987)3.49942455
41Bundle branch block (HP:0011710)3.45177359
42Ulnar deviation of the wrist (HP:0003049)3.39281907
43Ventricular arrhythmia (HP:0004308)3.37767338
44Hyperglycinuria (HP:0003108)3.32349961
45Abnormality of skeletal muscle fiber size (HP:0012084)3.30787202
46Prolonged QT interval (HP:0001657)3.23604683
47Atrioventricular block (HP:0001678)3.22745015
48Increased connective tissue (HP:0009025)3.17438069
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15904451
50Heart block (HP:0012722)3.15251016
51EMG: neuropathic changes (HP:0003445)3.15153942
52EMG: myopathic abnormalities (HP:0003458)3.12212291
53Generalized aminoaciduria (HP:0002909)3.09357474
54Areflexia of lower limbs (HP:0002522)3.08509724
55Hepatic necrosis (HP:0002605)3.02905834
56Abnormality of serine family amino acid metabolism (HP:0010894)2.94970246
57Abnormality of glycine metabolism (HP:0010895)2.94970246
58Abnormal atrioventricular conduction (HP:0005150)2.93986135
59Cerebral edema (HP:0002181)2.92155915
60Increased variability in muscle fiber diameter (HP:0003557)2.91432742
61Absent phalangeal crease (HP:0006109)2.84216313
62Deep venous thrombosis (HP:0002625)2.81949296
63Intrahepatic cholestasis (HP:0001406)2.78786185
64Generalized muscle weakness (HP:0003324)2.76650444
65Calcaneovalgus deformity (HP:0001848)2.71362270
66Hyperinsulinemic hypoglycemia (HP:0000825)2.69955084
67Hypoalphalipoproteinemia (HP:0003233)2.64296454
68Xanthomatosis (HP:0000991)2.61816545
69Ventricular fibrillation (HP:0001663)2.58751031
70Proximal tubulopathy (HP:0000114)2.58446233
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57524427
72Ragged-red muscle fibers (HP:0003200)2.54023554
73Hyperglycinemia (HP:0002154)2.47675806
74Metabolic acidosis (HP:0001942)2.47101834
75Abnormal finger flexion creases (HP:0006143)2.46668499
76Acute encephalopathy (HP:0006846)2.42396989
77Deformed tarsal bones (HP:0008119)2.39689806
78Renal cortical cysts (HP:0000803)2.36093708
79Abnormal mitochondria in muscle tissue (HP:0008316)2.35932958
80Hyperlipoproteinemia (HP:0010980)2.34898957
81Difficulty running (HP:0009046)2.34523605
82Scapular winging (HP:0003691)2.33278561
83Increased muscle lipid content (HP:0009058)2.33232786
84Lymphangioma (HP:0100764)2.30995078
85Conjunctival hamartoma (HP:0100780)2.29517133
86Blue irides (HP:0000635)2.29078554
87Nausea (HP:0002018)2.29030903
88Hypolipoproteinemia (HP:0010981)2.27819351
89Pheochromocytoma (HP:0002666)2.26466645
90Distal lower limb amyotrophy (HP:0008944)2.23617088
91Skin nodule (HP:0200036)2.23247792
92Mildly elevated creatine phosphokinase (HP:0008180)2.22588519
93Left ventricular hypertrophy (HP:0001712)2.21644985
94Myotonia (HP:0002486)2.20935056
95Lethargy (HP:0001254)2.18824264
96Abnormal EKG (HP:0003115)2.17084623
97Acute necrotizing encephalopathy (HP:0006965)2.15701696
98Hyperglycemia (HP:0003074)2.15244292
99Hepatocellular necrosis (HP:0001404)2.14959357
100Pancreatic islet-cell hyperplasia (HP:0004510)2.13910403
101Palmoplantar keratoderma (HP:0000982)2.13004084
102Abnormality of the foot musculature (HP:0001436)2.11649759
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11480224
104Lactic acidosis (HP:0003128)2.10443195
105Limb-girdle muscle atrophy (HP:0003797)2.09745093
106Gout (HP:0001997)2.09186720
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05856414
108Hypoglycemic seizures (HP:0002173)2.05610510
109Gowers sign (HP:0003391)2.03189948
110Abnormality of the ischium (HP:0003174)2.03125833
111Hypobetalipoproteinemia (HP:0003563)2.01950470
112Distal lower limb muscle weakness (HP:0009053)2.01463246
113Hypoplastic ischia (HP:0003175)2.01199393
114Abnormality of alanine metabolism (HP:0010916)2.00834514
115Hyperalaninemia (HP:0003348)2.00834514
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00834514
117Dysmetric saccades (HP:0000641)2.00418244
118Abnormality of serum amino acid levels (HP:0003112)2.00058259
119Late onset (HP:0003584)1.99453898
120Vomiting (HP:0002013)1.99275687
121Neoplasm of the adrenal gland (HP:0100631)1.97799438
122Type 1 muscle fiber predominance (HP:0003803)1.96951347
123Muscular dystrophy (HP:0003560)1.95950113
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95723979
125Hyperkalemia (HP:0002153)1.95249051
126Muscle stiffness (HP:0003552)1.95009124
127Hip contracture (HP:0003273)1.94837197
128Prolonged partial thromboplastin time (HP:0003645)1.94476225
129Proximal amyotrophy (HP:0007126)1.92787723
130Abnormality of glycolysis (HP:0004366)1.91514842
131Lower limb amyotrophy (HP:0007210)1.91412211
132Increased CSF lactate (HP:0002490)1.91153159
133Neoplasm of head and neck (HP:0012288)1.89327286
134Esophageal neoplasm (HP:0100751)1.89327286
135Long clavicles (HP:0000890)1.88911338
136Sudden cardiac death (HP:0001645)1.88853967
137Cholelithiasis (HP:0001081)1.88745689
138Hyperventilation (HP:0002883)1.88555871
139Increased intramyocellular lipid droplets (HP:0012240)1.87905683
140Malignant hyperthermia (HP:0002047)1.86471680
141Foot dorsiflexor weakness (HP:0009027)1.86045525
142Steppage gait (HP:0003376)1.83183436
143Fetal akinesia sequence (HP:0001989)1.80097495
144Neuroendocrine neoplasm (HP:0100634)1.74848661
145Increased serum pyruvate (HP:0003542)1.73649332
146Slender build (HP:0001533)1.70081854
147Abnormality of the calcaneus (HP:0008364)1.66336034
148Abnormality of the shoulder girdle musculature (HP:0001435)1.63753005
149Weak cry (HP:0001612)1.59373663
150Metatarsus adductus (HP:0001840)1.52225448
151Bulbar palsy (HP:0001283)1.50516949
152Spinal rigidity (HP:0003306)1.50384731
153Difficulty climbing stairs (HP:0003551)1.47446775
154Progressive muscle weakness (HP:0003323)1.46675636
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.46425983
156Limited hip movement (HP:0008800)1.44549534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.23575708
2BCKDK4.04935184
3OBSCN3.91775279
4PKN23.85327775
5PDK43.48714734
6PDK33.48714734
7MYLK3.22376466
8LMTK23.17267175
9TRIB33.05186134
10PHKG22.79453455
11PHKG12.79453455
12FRK2.68490241
13NEK12.36125610
14DMPK2.32470344
15TIE12.12056833
16MARK11.99589476
17INSRR1.98952540
18PDK21.97875770
19FLT31.88135781
20STK241.78826959
21PIK3CA1.77128843
22SIK11.63808824
23WNK41.57308384
24PINK11.49954858
25MAP2K31.42591154
26STK38L1.30647466
27STK41.27032930
28ERN11.24372010
29EEF2K1.23579832
30GRK71.23312955
31FGFR41.20128396
32MAP3K71.19906553
33PAK31.11745272
34CCNB11.11254159
35PRKD11.08530072
36ZAK1.07829283
37SCYL21.07668373
38NEK91.07211680
39PTK61.06086396
40PRKAA21.02244409
41PDGFRA1.00616418
42TGFBR20.97927853
43ERBB30.93710616
44PRKAA10.93487475
45ILK0.93011363
46BMPR1B0.92322703
47TRPM70.91432032
48MUSK0.89446103
49WEE10.87832115
50NTRK30.86878364
51MAP2K10.85652411
52CAMK40.84830532
53KDR0.84304756
54CAMK2D0.83566353
55MAPK120.82059669
56PIK3CG0.81297153
57MAPK130.80326210
58MAPK70.80101939
59LIMK10.77072767
60LATS10.75158079
61ROCK10.73132570
62MAP3K50.71699922
63RIPK10.70431566
64CAMKK20.70238077
65CDC42BPA0.68644473
66MAPK40.66515235
67CAMK2B0.66343774
68ACVR1B0.66041168
69MAP3K100.65631787
70MAP3K30.61433212
71RPS6KL10.58957576
72RPS6KC10.58957576
73MAPK110.57891578
74PRKG10.54892191
75PAK60.52353320
76RPS6KA60.50146744
77JAK10.49135894
78SGK30.48216438
79PRKACG0.45488673
80STK380.44634702
81WNK10.43863331
82LRRK20.42736796
83DAPK30.42349623
84TYK20.41715818
85PNCK0.41668029
86RPS6KA30.41658412
87MAPKAPK50.40905498
88EPHB10.40778483
89JAK20.40554331
90PRKACB0.40301921
91EPHA30.39201271
92RPS6KB10.37698567
93UHMK10.37445672
94SGK20.36009927
95AKT20.35846149
96MTOR0.35450862
97MAPKAPK30.35148294
98WNK30.34892379
99PKN10.33955610
100TGFBR10.33706448
101SGK10.32778144
102BRSK20.32619399
103MAPK100.32351150
104RPS6KB20.32093729
105MARK30.31053027
106FER0.30249733
107MAP4K20.30025931
108CAMK1D0.29113906
109SGK4940.28970677
110SGK2230.28970677
111ADRBK10.28813955
112FGFR30.28607359
113PLK20.28198841
114DAPK20.27794421
115STK390.27774107
116RET0.27763895
117CDK40.27614830
118PRKACA0.27356467
119MAP3K60.26616590
120PTK2B0.25279147
121PDPK10.25115674
122MAP2K60.24998246
123MAP2K40.24922798
124STK110.24540021
125PRKCH0.24400036
126ICK0.24131219
127MAP3K40.23782020
128TAOK30.23604060
129PDK10.23273370
130MET0.23103819
131CAMK10.22536970
132STK30.22144956
133RPS6KA10.21700913
134NME20.21557929
135CAMK2A0.21241071
136MST1R0.20904374
137ITK0.20898117
138KSR20.20452568
139ZAP700.19411478
140ROCK20.19371557
141PRKCQ0.18581785
142MAPK30.17627038
143TBK10.17608983
144CAMK2G0.17395263
145PRKCE0.16266124

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.44199306
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.96569061
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.89831460
4Fatty acid degradation_Homo sapiens_hsa000713.70436677
5Propanoate metabolism_Homo sapiens_hsa006403.56790827
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27957330
7Fatty acid metabolism_Homo sapiens_hsa012122.75124679
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71980815
9Butanoate metabolism_Homo sapiens_hsa006502.42662662
10Carbon metabolism_Homo sapiens_hsa012002.42521464
11Tryptophan metabolism_Homo sapiens_hsa003802.36026687
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.17954299
13Pyruvate metabolism_Homo sapiens_hsa006202.12384039
14Arginine biosynthesis_Homo sapiens_hsa002202.11497083
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01259982
16Cardiac muscle contraction_Homo sapiens_hsa042601.96755960
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93059174
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87830143
19Dilated cardiomyopathy_Homo sapiens_hsa054141.81532519
20Peroxisome_Homo sapiens_hsa041461.81140547
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79328843
22PPAR signaling pathway_Homo sapiens_hsa033201.77116768
23Fatty acid elongation_Homo sapiens_hsa000621.70811138
24Circadian rhythm_Homo sapiens_hsa047101.66613672
25Nitrogen metabolism_Homo sapiens_hsa009101.65969234
26beta-Alanine metabolism_Homo sapiens_hsa004101.64482525
27Starch and sucrose metabolism_Homo sapiens_hsa005001.57723947
28Biosynthesis of amino acids_Homo sapiens_hsa012301.50640543
29Parkinsons disease_Homo sapiens_hsa050121.43493491
30Calcium signaling pathway_Homo sapiens_hsa040201.39917169
31Lysine degradation_Homo sapiens_hsa003101.38340411
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37123040
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33763831
34Oxidative phosphorylation_Homo sapiens_hsa001901.31652261
35Oxytocin signaling pathway_Homo sapiens_hsa049211.28837830
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27371268
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26143748
38Renin secretion_Homo sapiens_hsa049241.25042898
39Complement and coagulation cascades_Homo sapiens_hsa046101.20161062
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15305892
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12726598
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11475164
43Phenylalanine metabolism_Homo sapiens_hsa003601.11444023
44Selenocompound metabolism_Homo sapiens_hsa004501.10206438
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.08745164
46Arginine and proline metabolism_Homo sapiens_hsa003301.08664445
47Circadian entrainment_Homo sapiens_hsa047131.01449524
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97258541
49Gastric acid secretion_Homo sapiens_hsa049710.95593621
50Linoleic acid metabolism_Homo sapiens_hsa005910.95478646
51Alzheimers disease_Homo sapiens_hsa050100.95423238
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.92541204
53Bile secretion_Homo sapiens_hsa049760.89011645
54Insulin secretion_Homo sapiens_hsa049110.88489732
55Tyrosine metabolism_Homo sapiens_hsa003500.86810476
56Insulin resistance_Homo sapiens_hsa049310.85394924
57Chemical carcinogenesis_Homo sapiens_hsa052040.82695295
58Fat digestion and absorption_Homo sapiens_hsa049750.81539290
59Caffeine metabolism_Homo sapiens_hsa002320.80983189
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80060163
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78634431
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77927262
63Sulfur metabolism_Homo sapiens_hsa009200.76809294
64Histidine metabolism_Homo sapiens_hsa003400.74059070
65Viral myocarditis_Homo sapiens_hsa054160.73943092
66Huntingtons disease_Homo sapiens_hsa050160.71951332
67ABC transporters_Homo sapiens_hsa020100.70242904
68Glucagon signaling pathway_Homo sapiens_hsa049220.69182481
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.69039029
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.67152377
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.66488881
72GABAergic synapse_Homo sapiens_hsa047270.65054660
73Salivary secretion_Homo sapiens_hsa049700.63101142
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62196292
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61583525
76Galactose metabolism_Homo sapiens_hsa000520.60505084
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59783205
78Retinol metabolism_Homo sapiens_hsa008300.59067137
79Staphylococcus aureus infection_Homo sapiens_hsa051500.58081086
80Cholinergic synapse_Homo sapiens_hsa047250.56217400
81Amphetamine addiction_Homo sapiens_hsa050310.55848177
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.54510440
83Pancreatic secretion_Homo sapiens_hsa049720.53031436
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52446713
85cAMP signaling pathway_Homo sapiens_hsa040240.52030397
86Platelet activation_Homo sapiens_hsa046110.51776269
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51684690
88Long-term depression_Homo sapiens_hsa047300.51517655
89Morphine addiction_Homo sapiens_hsa050320.49717472
90* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49366172
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48041785
92Long-term potentiation_Homo sapiens_hsa047200.47599848
93Folate biosynthesis_Homo sapiens_hsa007900.46520925
94Fatty acid biosynthesis_Homo sapiens_hsa000610.46376498
95* Metabolic pathways_Homo sapiens_hsa011000.44741734
96Glutamatergic synapse_Homo sapiens_hsa047240.43755686
97AMPK signaling pathway_Homo sapiens_hsa041520.43385252
98Glycerolipid metabolism_Homo sapiens_hsa005610.42976402
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42083162
100Pentose phosphate pathway_Homo sapiens_hsa000300.41818704
101Insulin signaling pathway_Homo sapiens_hsa049100.41382406
102Glutathione metabolism_Homo sapiens_hsa004800.39265543
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39130468
104GnRH signaling pathway_Homo sapiens_hsa049120.37718793
105Olfactory transduction_Homo sapiens_hsa047400.37538102
106Fructose and mannose metabolism_Homo sapiens_hsa000510.36805810
107mTOR signaling pathway_Homo sapiens_hsa041500.34666156
108Thyroid hormone synthesis_Homo sapiens_hsa049180.34340730
109One carbon pool by folate_Homo sapiens_hsa006700.33707936
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.32701313
111Dopaminergic synapse_Homo sapiens_hsa047280.32143873
112Serotonergic synapse_Homo sapiens_hsa047260.30978862
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30314281
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27347659
115Sulfur relay system_Homo sapiens_hsa041220.24817438
116Vitamin digestion and absorption_Homo sapiens_hsa049770.24686461
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.22379773
118Focal adhesion_Homo sapiens_hsa045100.19342368
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17943828
120Type II diabetes mellitus_Homo sapiens_hsa049300.13780926
121HIF-1 signaling pathway_Homo sapiens_hsa040660.13433346
122ECM-receptor interaction_Homo sapiens_hsa045120.09212982
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06464714
124Adherens junction_Homo sapiens_hsa045200.02572486
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00655761
126Protein digestion and absorption_Homo sapiens_hsa049740.00335380
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0974450
128Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0884492
129Small cell lung cancer_Homo sapiens_hsa05222-0.0552058
130alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0272897
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0268680
132Amoebiasis_Homo sapiens_hsa05146-0.0223142

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