NOA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.69759259
2translational elongation (GO:0006414)5.12930530
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.94796803
4cotranslational protein targeting to membrane (GO:0006613)4.85017040
5protein targeting to ER (GO:0045047)4.75678323
6telomere maintenance via semi-conservative replication (GO:0032201)4.62012440
7DNA replication checkpoint (GO:0000076)4.60950300
8establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55773112
9nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.53410302
10viral life cycle (GO:0019058)4.46155005
11protein localization to endoplasmic reticulum (GO:0070972)4.45375928
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.36545808
13proteasome assembly (GO:0043248)4.33035204
14DNA strand elongation involved in DNA replication (GO:0006271)4.32965956
15DNA replication initiation (GO:0006270)4.30928696
16cellular protein complex disassembly (GO:0043624)4.22335374
17DNA strand elongation (GO:0022616)4.18715864
18telomere maintenance via recombination (GO:0000722)4.15313727
19ribosomal small subunit assembly (GO:0000028)4.06274435
20rRNA modification (GO:0000154)3.97756819
21pseudouridine synthesis (GO:0001522)3.96031463
22iron-sulfur cluster assembly (GO:0016226)3.94995596
23metallo-sulfur cluster assembly (GO:0031163)3.94995596
24maturation of SSU-rRNA (GO:0030490)3.92244103
25ribosome assembly (GO:0042255)3.87140348
26ribosomal large subunit biogenesis (GO:0042273)3.86657441
27protein complex disassembly (GO:0043241)3.82341694
28regulation of double-strand break repair via homologous recombination (GO:0010569)3.82018151
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.78260080
30termination of RNA polymerase III transcription (GO:0006386)3.78260080
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77936027
32* ribosome biogenesis (GO:0042254)3.76762206
33ubiquinone biosynthetic process (GO:0006744)3.76672514
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76536083
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.76536083
36mitotic recombination (GO:0006312)3.76051199
37telomere maintenance via telomere lengthening (GO:0010833)3.74407223
38CENP-A containing nucleosome assembly (GO:0034080)3.74318118
39macromolecular complex disassembly (GO:0032984)3.70312288
40* ribonucleoprotein complex biogenesis (GO:0022613)3.70183518
41nucleobase biosynthetic process (GO:0046112)3.69071875
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.66730276
43mitotic metaphase plate congression (GO:0007080)3.65791651
44chromatin remodeling at centromere (GO:0031055)3.65481252
45purine nucleobase biosynthetic process (GO:0009113)3.59354497
46tRNA methylation (GO:0030488)3.59122171
47mRNA catabolic process (GO:0006402)3.52992844
48kinetochore assembly (GO:0051382)3.52935389
49rRNA processing (GO:0006364)3.52158209
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48651839
51ribosomal small subunit biogenesis (GO:0042274)3.48208792
52formation of translation preinitiation complex (GO:0001731)3.45207757
53rRNA metabolic process (GO:0016072)3.44513746
54ubiquinone metabolic process (GO:0006743)3.42592224
55spliceosomal snRNP assembly (GO:0000387)3.42557810
56transcription-coupled nucleotide-excision repair (GO:0006283)3.39080428
57kinetochore organization (GO:0051383)3.37503217
58IMP biosynthetic process (GO:0006188)3.37234615
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29979702
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.29516994
61NADH dehydrogenase complex assembly (GO:0010257)3.29516994
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29516994
637-methylguanosine mRNA capping (GO:0006370)3.27585186
64RNA catabolic process (GO:0006401)3.25247105
65protein targeting to membrane (GO:0006612)3.24864851
66RNA capping (GO:0036260)3.24475210
677-methylguanosine RNA capping (GO:0009452)3.24475210
68DNA replication-independent nucleosome assembly (GO:0006336)3.23792243
69DNA replication-independent nucleosome organization (GO:0034724)3.23792243
70rRNA methylation (GO:0031167)3.23403717
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.23150819
72ncRNA 3-end processing (GO:0043628)3.22661654
73maturation of 5.8S rRNA (GO:0000460)3.21789166
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20694462
75mitochondrial respiratory chain complex assembly (GO:0033108)3.20094568
76DNA-dependent DNA replication (GO:0006261)3.19602727
77termination of RNA polymerase I transcription (GO:0006363)3.18447728
78positive regulation of mitochondrial fission (GO:0090141)3.17004857
79transcription from RNA polymerase I promoter (GO:0006360)3.16961940
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15437967
81protein complex biogenesis (GO:0070271)3.15195933
82respiratory chain complex IV assembly (GO:0008535)3.14890153
83mitochondrial RNA metabolic process (GO:0000959)3.13579406
84GMP metabolic process (GO:0046037)3.13387958
85metaphase plate congression (GO:0051310)3.08611226
86mitochondrial calcium ion transport (GO:0006851)3.08176679
87DNA synthesis involved in DNA repair (GO:0000731)3.07319212
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06367963
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05941964
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05008511
91viral transcription (GO:0019083)3.03637096
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02955202
93translational termination (GO:0006415)3.02734045
94protein localization to kinetochore (GO:0034501)3.01789097
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01686358
96RNA methylation (GO:0001510)3.00138748
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.99760641
98response to pheromone (GO:0019236)2.99064877
99quinone biosynthetic process (GO:1901663)2.98883423
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.98206329
101deoxyribonucleotide biosynthetic process (GO:0009263)2.95860079
102* cellular component biogenesis (GO:0044085)2.95420797
103meiotic chromosome segregation (GO:0045132)2.95405557
104tRNA modification (GO:0006400)2.94352056
105peptidyl-arginine omega-N-methylation (GO:0035247)2.94237861
106protein K6-linked ubiquitination (GO:0085020)2.94104717
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92812080
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92147308
109histone exchange (GO:0043486)2.92009375
110ncRNA processing (GO:0034470)2.91657287
111telomere maintenance (GO:0000723)2.89428351
112telomere organization (GO:0032200)2.88927029
113DNA-templated transcription, termination (GO:0006353)2.88736792
114G1/S transition of mitotic cell cycle (GO:0000082)2.88063844
115cell cycle G1/S phase transition (GO:0044843)2.88063844
116translational initiation (GO:0006413)2.87142736
117DNA replication (GO:0006260)2.86670943
118regulation of mitochondrial translation (GO:0070129)2.86019188
119mitochondrial DNA replication (GO:0006264)2.85728205
120DNA damage response, detection of DNA damage (GO:0042769)2.85187689
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85050058
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85050058
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85050058
124oxidative phosphorylation (GO:0006119)2.83195673
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.82368880
126negative regulation of ligase activity (GO:0051352)2.81904531
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81904531
128cytochrome complex assembly (GO:0017004)2.81792036
129IMP metabolic process (GO:0046040)2.81652841
130replication fork processing (GO:0031297)2.81652406
131ncRNA metabolic process (GO:0034660)2.81268709
132protein localization to chromosome, centromeric region (GO:0071459)2.80218166
133mitotic nuclear envelope disassembly (GO:0007077)2.79210036
134energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78889874
135ATP synthesis coupled proton transport (GO:0015986)2.78889874
136* translation (GO:0006412)2.78318787
137negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78192435
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77577817
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.77577817
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.76535436
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76455344
142viral mRNA export from host cell nucleus (GO:0046784)2.75680314
143histone arginine methylation (GO:0034969)2.75540246
144base-excision repair, AP site formation (GO:0006285)2.74617602
145protein-cofactor linkage (GO:0018065)2.63930996
146protein targeting to mitochondrion (GO:0006626)2.63545921
147chromatin assembly (GO:0031497)2.63524307
148DNA replication-dependent nucleosome assembly (GO:0006335)2.61424822
149DNA replication-dependent nucleosome organization (GO:0034723)2.61424822
150establishment of protein localization to mitochondrion (GO:0072655)2.59468220
151nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.57434343
152tolerance induction (GO:0002507)2.53725226
153tRNA aminoacylation (GO:0043039)2.51038194
154amino acid activation (GO:0043038)2.51038194
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50421079
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50421079
157tRNA aminoacylation for protein translation (GO:0006418)2.49969379
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49879965
159peptidyl-arginine N-methylation (GO:0035246)2.49199281
160peptidyl-arginine methylation (GO:0018216)2.49199281
161rRNA transcription (GO:0009303)2.48355665
162aerobic respiration (GO:0009060)2.47575374
163spliceosomal tri-snRNP complex assembly (GO:0000244)2.46958153
164negative regulation of DNA-templated transcription, elongation (GO:0032785)2.46270365
165negative regulation of RNA splicing (GO:0033119)2.44930079
166tRNA metabolic process (GO:0006399)2.44485078
167ribonucleoprotein complex assembly (GO:0022618)2.42553080
168transcription from RNA polymerase III promoter (GO:0006383)2.42282177
169mannosylation (GO:0097502)2.41302588
170pyrimidine nucleotide catabolic process (GO:0006244)2.40928659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.75062056
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43489342
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72744569
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47017298
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.44603331
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37599173
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.34610101
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.34597096
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.13846593
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01621922
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96600028
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94822820
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90203263
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.81259821
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74604129
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63458208
17VDR_23849224_ChIP-Seq_CD4+_Human2.61902672
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57926165
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50643699
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30633942
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29501275
22XRN2_22483619_ChIP-Seq_HELA_Human2.24333263
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23788458
24FOXP3_21729870_ChIP-Seq_TREG_Human2.19616394
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19575807
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18770724
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10556174
28DCP1A_22483619_ChIP-Seq_HELA_Human2.10379007
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.09697989
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07438480
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98168326
32GABP_19822575_ChIP-Seq_HepG2_Human1.95876387
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95575276
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95029456
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93744033
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92314251
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91528399
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90955689
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.90322899
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.89634155
41TTF2_22483619_ChIP-Seq_HELA_Human1.89105455
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.88592199
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87539272
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87137172
45ELK1_19687146_ChIP-ChIP_HELA_Human1.82020985
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.78365717
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71610423
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68732042
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68133713
50ZNF274_21170338_ChIP-Seq_K562_Hela1.67959573
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63963360
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63815368
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62261901
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60522654
55CIITA_25753668_ChIP-Seq_RAJI_Human1.60167680
56AR_21909140_ChIP-Seq_LNCAP_Human1.57800772
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57757350
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48097854
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41005042
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40113948
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37100540
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36727371
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36215541
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34954371
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22255348
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21436307
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15631666
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15253415
69VDR_21846776_ChIP-Seq_THP-1_Human1.14364290
70* SPI1_23547873_ChIP-Seq_NB4_Human1.13735011
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13704937
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13256086
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.13181709
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13175173
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12426709
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12061219
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11525441
78MYC_18940864_ChIP-ChIP_HL60_Human1.11144496
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10370542
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.06713361
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06581924
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06277984
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.05277927
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04773854
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99475210
86MYC_22102868_ChIP-Seq_BL_Human0.98878443
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98229059
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97702103
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96298401
90TFEB_21752829_ChIP-Seq_HELA_Human0.96294594
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95980537
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93485202
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93424004
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.91357234
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89767525
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87742495
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87274295
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83139306
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82684364
100MAF_26560356_Chip-Seq_TH2_Human0.82556239
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82238657
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80358277
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79513972
104ZNF263_19887448_ChIP-Seq_K562_Human0.78374754
105YY1_22570637_ChIP-Seq_MALME-3M_Human0.77979932
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76118563
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75742477
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72284041
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72120199
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71584464
111IRF1_19129219_ChIP-ChIP_H3396_Human0.71123554
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.69014051
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.68660419
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.67754105
115CTCF_18555785_ChIP-Seq_MESCs_Mouse0.65471360
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64651940
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62994680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.28709157
2MP0003111_abnormal_nucleus_morphology4.24328321
3MP0008057_abnormal_DNA_replication4.13899310
4MP0010094_abnormal_chromosome_stability3.99767855
5MP0008058_abnormal_DNA_repair3.77697150
6MP0003077_abnormal_cell_cycle3.52709420
7MP0004957_abnormal_blastocyst_morpholog3.51416345
8MP0008007_abnormal_cellular_replicative3.14185921
9MP0005645_abnormal_hypothalamus_physiol3.10419930
10MP0002653_abnormal_ependyma_morphology2.84828735
11MP0006292_abnormal_olfactory_placode2.68491797
12MP0002396_abnormal_hematopoietic_system2.65580402
13MP0003786_premature_aging2.40536760
14MP0008932_abnormal_embryonic_tissue2.28297968
15MP0000490_abnormal_crypts_of2.09408658
16MP0002009_preneoplasia2.07716646
17MP0008877_abnormal_DNA_methylation2.02861286
18MP0004145_abnormal_muscle_electrophysio2.00926680
19MP0001529_abnormal_vocalization1.89159186
20MP0003763_abnormal_thymus_physiology1.87125503
21MP0002837_dystrophic_cardiac_calcinosis1.82989755
22MP0003718_maternal_effect1.78793142
23MP0009333_abnormal_splenocyte_physiolog1.76884585
24MP0006036_abnormal_mitochondrial_physio1.72006926
25MP0002132_abnormal_respiratory_system1.71966643
26MP0001188_hyperpigmentation1.71485632
27MP0001764_abnormal_homeostasis1.68563876
28MP0005379_endocrine/exocrine_gland_phen1.65805191
29MP0005075_abnormal_melanosome_morpholog1.62354273
30MP0005083_abnormal_biliary_tract1.59957367
31MP0000350_abnormal_cell_proliferation1.58804405
32MP0006035_abnormal_mitochondrial_morpho1.53442069
33MP0000015_abnormal_ear_pigmentation1.53398956
34MP0002277_abnormal_respiratory_mucosa1.45963873
35MP0000685_abnormal_immune_system1.45566507
36MP0003806_abnormal_nucleotide_metabolis1.44956372
37MP0001873_stomach_inflammation1.43446825
38MP0000313_abnormal_cell_death1.41936685
39MP0009697_abnormal_copulation1.36074106
40MP0003787_abnormal_imprinting1.32764436
41MP0003136_yellow_coat_color1.32676890
42MP0001545_abnormal_hematopoietic_system1.31996285
43MP0005397_hematopoietic_system_phenotyp1.31996285
44MP0002019_abnormal_tumor_incidence1.30585588
45MP0002160_abnormal_reproductive_system1.30126091
46MP0001730_embryonic_growth_arrest1.29677494
47MP0002398_abnormal_bone_marrow1.29224752
48MP0002210_abnormal_sex_determination1.24936495
49MP0003941_abnormal_skin_development1.24273271
50MP0002095_abnormal_skin_pigmentation1.23958881
51MP0000703_abnormal_thymus_morphology1.23882533
52MP0001835_abnormal_antigen_presentation1.22967531
53MP0004808_abnormal_hematopoietic_stem1.22462548
54MP0001853_heart_inflammation1.21229397
55MP0005174_abnormal_tail_pigmentation1.20457526
56MP0003186_abnormal_redox_activity1.19463799
57MP0002722_abnormal_immune_system1.19364279
58MP0000689_abnormal_spleen_morphology1.19259385
59MP0005671_abnormal_response_to1.13620257
60MP0005501_abnormal_skin_physiology1.11866369
61MP0008789_abnormal_olfactory_epithelium1.11432865
62MP0005084_abnormal_gallbladder_morpholo1.10813164
63MP0003646_muscle_fatigue1.10627257
64MP0005389_reproductive_system_phenotype1.09800595
65MP0001672_abnormal_embryogenesis/_devel1.09709699
66MP0005380_embryogenesis_phenotype1.09709699
67MP0006072_abnormal_retinal_apoptosis1.07643163
68MP0001119_abnormal_female_reproductive1.07152465
69MP0000566_synostosis1.06689049
70MP0010307_abnormal_tumor_latency1.05197325
71MP0010030_abnormal_orbit_morphology1.04763002
72MP0000858_altered_metastatic_potential1.04555248
73MP0003315_abnormal_perineum_morphology1.04189202
74MP0001186_pigmentation_phenotype1.03281755
75MP0008260_abnormal_autophagy1.03165489
76MP0004133_heterotaxia1.02099840
77MP0001145_abnormal_male_reproductive1.01284293
78MP0002429_abnormal_blood_cell1.00986565
79MP0001697_abnormal_embryo_size0.99015597
80MP0004142_abnormal_muscle_tone0.99011751
81MP0009785_altered_susceptibility_to0.98910688
82MP0002166_altered_tumor_susceptibility0.98726056
83MP0000716_abnormal_immune_system0.98620078
84MP0004233_abnormal_muscle_weight0.98585487
85MP0002080_prenatal_lethality0.98161825
86MP0008995_early_reproductive_senescence0.96212580
87MP0002693_abnormal_pancreas_physiology0.95703594
88MP0004197_abnormal_fetal_growth/weight/0.95576476
89MP0000372_irregular_coat_pigmentation0.95449653
90MP0010352_gastrointestinal_tract_polyps0.94960661
91MP0002638_abnormal_pupillary_reflex0.94898508
92MP0002148_abnormal_hypersensitivity_rea0.94719561
93MP0003567_abnormal_fetal_cardiomyocyte0.94380766
94MP0002102_abnormal_ear_morphology0.94120726
95MP0001800_abnormal_humoral_immune0.93293847
96MP0002938_white_spotting0.92793169
97MP0001919_abnormal_reproductive_system0.92149313
98MP0003984_embryonic_growth_retardation0.91004667
99MP0005220_abnormal_exocrine_pancreas0.90399793
100MP0000653_abnormal_sex_gland0.89975915
101MP0002075_abnormal_coat/hair_pigmentati0.89768514
102MP0002452_abnormal_antigen_presenting0.89734212
103MP0002420_abnormal_adaptive_immunity0.89691807
104MP0001819_abnormal_immune_cell0.88791220
105MP0004381_abnormal_hair_follicle0.88589030
106MP0002085_abnormal_embryonic_tissue0.88062448
107MP0003698_abnormal_male_reproductive0.87603566
108MP0002006_tumorigenesis0.87522161
109MP0009379_abnormal_foot_pigmentation0.87196725
110MP0000631_abnormal_neuroendocrine_gland0.86748561
111MP0002723_abnormal_immune_serum0.86464553
112MP0000358_abnormal_cell_content/0.86317249
113MP0002088_abnormal_embryonic_growth/wei0.86164232
114MP0001929_abnormal_gametogenesis0.85281662
115MP0001986_abnormal_taste_sensitivity0.84956968
116MP0004147_increased_porphyrin_level0.84538427
117MP0003123_paternal_imprinting0.83110084
118MP0008961_abnormal_basal_metabolism0.80975835
119MP0003878_abnormal_ear_physiology0.79442489
120MP0005377_hearing/vestibular/ear_phenot0.79442489
121MP0002163_abnormal_gland_morphology0.78307084
122MP0005000_abnormal_immune_tolerance0.77649425
123MP0005025_abnormal_response_to0.77189701
124MP0000678_abnormal_parathyroid_gland0.76770476
125MP0002405_respiratory_system_inflammati0.76724998
126MP0000613_abnormal_salivary_gland0.75232767
127MP0001944_abnormal_pancreas_morphology0.73668617
128MP0000477_abnormal_intestine_morphology0.72630323
129MP0001286_abnormal_eye_development0.72291217
130MP0003436_decreased_susceptibility_to0.70736561
131MP0001293_anophthalmia0.70550008
132MP0000049_abnormal_middle_ear0.69963958
133MP0002084_abnormal_developmental_patter0.69960745
134MP0000371_diluted_coat_color0.69781330
135MP0005499_abnormal_olfactory_system0.69308211
136MP0005394_taste/olfaction_phenotype0.69308211
137MP0000750_abnormal_muscle_regeneration0.68964271
138MP0002796_impaired_skin_barrier0.67700817
139MP0009278_abnormal_bone_marrow0.67398496
140MP0005384_cellular_phenotype0.67002142
141MP0004264_abnormal_extraembryonic_tissu0.66926813

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.10124374
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.78884593
3Chromsome breakage (HP:0040012)4.64108943
4Abnormality of cells of the erythroid lineage (HP:0012130)3.87262332
5Abnormal number of erythroid precursors (HP:0012131)3.76913856
6Breast hypoplasia (HP:0003187)3.69573163
7Reticulocytopenia (HP:0001896)3.65022939
8Abnormal mitochondria in muscle tissue (HP:0008316)3.63187287
9Increased CSF lactate (HP:0002490)3.49017247
10Acute necrotizing encephalopathy (HP:0006965)3.48730077
11Mitochondrial inheritance (HP:0001427)3.45099520
12Hepatocellular necrosis (HP:0001404)3.38086269
13Aplastic anemia (HP:0001915)3.33473650
14Meckel diverticulum (HP:0002245)3.31471513
15Abnormality of the preputium (HP:0100587)3.31450097
16Increased intramyocellular lipid droplets (HP:0012240)3.22823141
17Abnormality of the ileum (HP:0001549)3.16080485
18Increased hepatocellular lipid droplets (HP:0006565)3.13732527
19Acute encephalopathy (HP:0006846)3.13707609
20Lipid accumulation in hepatocytes (HP:0006561)3.12239136
21Hepatic necrosis (HP:0002605)3.11058213
22Type I transferrin isoform profile (HP:0003642)3.10744426
23Microvesicular hepatic steatosis (HP:0001414)3.03845475
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.03311143
25Abnormality of chromosome stability (HP:0003220)2.99777202
26Oral leukoplakia (HP:0002745)2.88966348
27Rough bone trabeculation (HP:0100670)2.88922027
28Patellar aplasia (HP:0006443)2.88404253
29Increased muscle lipid content (HP:0009058)2.86620928
30Carpal bone hypoplasia (HP:0001498)2.85627919
31Aplasia/hypoplasia of the uterus (HP:0008684)2.82742149
32Type 2 muscle fiber atrophy (HP:0003554)2.79881190
33Aplasia/Hypoplasia of the patella (HP:0006498)2.78627315
34Lactic acidosis (HP:0003128)2.76822466
35Absent thumb (HP:0009777)2.75123878
36Type II lissencephaly (HP:0007260)2.72888067
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.69513016
38Muscle fiber atrophy (HP:0100295)2.67688572
39Progressive macrocephaly (HP:0004481)2.62981260
40Cerebral edema (HP:0002181)2.58176526
41Macrocytic anemia (HP:0001972)2.56616145
42Cerebellar dysplasia (HP:0007033)2.56319841
43Chronic hepatic failure (HP:0100626)2.55477245
44Bone marrow hypocellularity (HP:0005528)2.55084173
45Microretrognathia (HP:0000308)2.54241502
46Duplicated collecting system (HP:0000081)2.52344213
47Reduced antithrombin III activity (HP:0001976)2.51899008
48Premature graying of hair (HP:0002216)2.51821961
49Pallor (HP:0000980)2.51711679
50Myelodysplasia (HP:0002863)2.48110901
51Cerebral hypomyelination (HP:0006808)2.45077576
523-Methylglutaconic aciduria (HP:0003535)2.43670875
53Abnormality of the renal collecting system (HP:0004742)2.40619981
54Hypoplasia of the pons (HP:0012110)2.39759564
55Hypoplasia of the uterus (HP:0000013)2.38894390
56Impulsivity (HP:0100710)2.37066775
57Duodenal stenosis (HP:0100867)2.35796194
58Small intestinal stenosis (HP:0012848)2.35796194
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34117360
60Abnormality of the anterior horn cell (HP:0006802)2.33789658
61Degeneration of anterior horn cells (HP:0002398)2.33789658
62Abnormal protein glycosylation (HP:0012346)2.31197406
63Abnormal glycosylation (HP:0012345)2.31197406
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31197406
65Abnormal protein N-linked glycosylation (HP:0012347)2.31197406
66Clubbing of toes (HP:0100760)2.29815242
67Abnormality of the pons (HP:0007361)2.27903992
68IgM deficiency (HP:0002850)2.27854995
69Ectopic kidney (HP:0000086)2.27520502
70Triphalangeal thumb (HP:0001199)2.27078884
71Abnormal spermatogenesis (HP:0008669)2.23664876
72Progressive muscle weakness (HP:0003323)2.22008665
73Petechiae (HP:0000967)2.18435511
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17524391
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17524391
76Absent radius (HP:0003974)2.16657145
77Abnormal trabecular bone morphology (HP:0100671)2.15129218
78Exercise intolerance (HP:0003546)2.15060941
79Abnormality of DNA repair (HP:0003254)2.14314965
80Pancreatic fibrosis (HP:0100732)2.14118518
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13483691
82Progressive external ophthalmoplegia (HP:0000590)2.13311938
83Congenital stationary night blindness (HP:0007642)2.13003207
84Squamous cell carcinoma (HP:0002860)2.12857148
85Granulocytopenia (HP:0001913)2.12623097
86Increased serum lactate (HP:0002151)2.12403686
87Sparse eyelashes (HP:0000653)2.11199275
88Pancytopenia (HP:0001876)2.09649759
89Horseshoe kidney (HP:0000085)2.09410939
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08616236
91Abnormality of the heme biosynthetic pathway (HP:0010472)2.02959996
92True hermaphroditism (HP:0010459)2.02607038
93Septate vagina (HP:0001153)2.01386221
94Tracheoesophageal fistula (HP:0002575)2.01279466
95Lymphoma (HP:0002665)2.01158856
96Absent forearm bone (HP:0003953)2.00937253
97Aplasia involving forearm bones (HP:0009822)2.00937253
98B lymphocytopenia (HP:0010976)1.99404660
99Cleft eyelid (HP:0000625)1.98964913
100Sloping forehead (HP:0000340)1.97876631
101Agammaglobulinemia (HP:0004432)1.95849241
102Partial agenesis of the corpus callosum (HP:0001338)1.95585000
103Pancreatic cysts (HP:0001737)1.95532884
104Basal cell carcinoma (HP:0002671)1.95485198
105Colon cancer (HP:0003003)1.95458293
106Molar tooth sign on MRI (HP:0002419)1.95391043
107Abnormality of midbrain morphology (HP:0002418)1.95391043
108Abnormality of alanine metabolism (HP:0010916)1.94717818
109Hyperalaninemia (HP:0003348)1.94717818
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94717818
111Abnormality of the carotid arteries (HP:0005344)1.94610784
112Abnormality of B cell number (HP:0010975)1.94509167
113Neoplasm of the adrenal cortex (HP:0100641)1.93677928
114Selective tooth agenesis (HP:0001592)1.93516538
11511 pairs of ribs (HP:0000878)1.93481434
116Facial cleft (HP:0002006)1.93465644
117Fibular aplasia (HP:0002990)1.92526230
118Trismus (HP:0000211)1.91885335
119Neoplasm of the pancreas (HP:0002894)1.91003152
120Secondary amenorrhea (HP:0000869)1.90053620
121Exertional dyspnea (HP:0002875)1.88768018
122Abnormal lung lobation (HP:0002101)1.88642521
123Ketosis (HP:0001946)1.87228441
124Optic nerve coloboma (HP:0000588)1.86780782
125Hypoplasia of the radius (HP:0002984)1.86114639
126Abnormality of the duodenum (HP:0002246)1.85321395
127Cellular immunodeficiency (HP:0005374)1.84970680
128Pulmonary fibrosis (HP:0002206)1.84575207
129Sclerocornea (HP:0000647)1.84446504
130Premature ovarian failure (HP:0008209)1.84059171
131Lethargy (HP:0001254)1.84049057
132Poor head control (HP:0002421)1.82318485
133Abnormality of T cell physiology (HP:0011840)1.80974345
134Agnosia (HP:0010524)1.80958926
135Supernumerary spleens (HP:0009799)1.80860621
136Medial flaring of the eyebrow (HP:0010747)1.80794077
137Abnormal number of incisors (HP:0011064)1.80451125
138IgG deficiency (HP:0004315)1.80308382
139Ketoacidosis (HP:0001993)1.77505189
140Short middle phalanx of the 5th finger (HP:0004220)1.77467982
141Azoospermia (HP:0000027)1.77253536
142Short thumb (HP:0009778)1.76830608
143Megaloblastic anemia (HP:0001889)1.76761899
144Optic disc pallor (HP:0000543)1.75321775
145Progressive inability to walk (HP:0002505)1.74689159
146Renal Fanconi syndrome (HP:0001994)1.73832871
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73596451
148Testicular atrophy (HP:0000029)1.70598526
149Tinnitus (HP:0000360)1.69772448
150Hypergonadotropic hypogonadism (HP:0000815)1.69025106
151Concave nail (HP:0001598)1.68886235
152Hyperammonemia (HP:0001987)1.67268664
153Respiratory failure (HP:0002878)1.66164319
154Hyperglycinuria (HP:0003108)1.64979372
155Progressive microcephaly (HP:0000253)1.61089496
156Metabolic acidosis (HP:0001942)1.60222531
157Abnormality of reticulocytes (HP:0004312)1.60104003
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.58642080
159Panhypogammaglobulinemia (HP:0003139)1.57692395
160Neoplasm of the adrenal gland (HP:0100631)1.56172259
161Symphalangism affecting the phalanges of the hand (HP:0009773)1.55984492
162Poikiloderma (HP:0001029)1.55537465
163Humeroradial synostosis (HP:0003041)1.53621091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.82626917
2BUB13.73912384
3IRAK33.61631320
4EIF2AK13.54631884
5BCKDK3.53280785
6ZAK3.23329316
7STK163.10810437
8WEE13.01215397
9SRPK12.81333126
10MAP4K22.60616045
11EIF2AK32.52203086
12NME22.50825923
13IRAK42.46428592
14CDC72.43996420
15VRK22.23973317
16MKNK22.19847073
17EEF2K2.11724219
18MAP3K132.03770125
19TTK2.03079928
20CDK191.96108903
21MKNK11.95805179
22BMPR1B1.94027247
23VRK11.90943552
24NUAK11.89982548
25DYRK31.80720722
26TAOK31.74185552
27ACVR1B1.69411021
28PLK11.68053791
29RPS6KA41.64513810
30TLK11.61798330
31TSSK61.56748864
32PIM21.53540845
33ATR1.50919920
34NEK21.49822264
35EIF2AK21.45255539
36BRSK21.43268354
37CDK71.37831467
38SMG11.35809714
39CHEK21.34296854
40PLK31.32731961
41TESK21.31130823
42IRAK21.27487391
43TXK1.26117839
44EPHA21.24924803
45AURKB1.23858084
46PASK1.18768860
47RPS6KB21.14135854
48PBK1.12748231
49STK38L1.12437855
50WNK41.09635854
51MAP2K71.05788695
52ARAF1.04133481
53TAF11.02593539
54AURKA1.01944221
55PINK10.97478933
56TEC0.96398864
57CSNK1G30.95282702
58IRAK10.92699291
59BRSK10.92399825
60MAP2K20.91299806
61NLK0.89145386
62MAP4K10.87749729
63CDK80.85939965
64PIM10.85236192
65CHEK10.85106466
66TAOK20.85083409
67NME10.84057926
68MAPK110.83532916
69KDR0.83348660
70TNIK0.82587730
71BRAF0.82571887
72MAPKAPK50.80222246
73CDK40.77618940
74MAP3K40.77105573
75IKBKB0.76545572
76CSNK1G10.75136349
77CSNK1A1L0.74385597
78AKT30.72964829
79MAP3K80.68378858
80PRKCI0.68041657
81BLK0.66621586
82STK40.66253248
83ATM0.65557808
84CSNK2A10.65264061
85CDK120.64857594
86ADRBK20.63520440
87PRKCQ0.63227823
88YES10.63194757
89BTK0.63092710
90CCNB10.61933725
91MAPKAPK30.61827069
92TGFBR10.61097014
93CAMKK10.58455901
94CSNK1G20.56066271
95RPS6KA50.55859304
96STK100.55725761
97DYRK20.55585021
98CDK20.54960627
99CSNK2A20.53202560
100STK240.51910867
101JAK30.51691717
102CLK10.50055677
103LRRK20.49583601
104NEK60.49496367
105TYK20.49269159
106BRD40.48934913
107MAP3K140.47452377
108CDK30.46987725
109MAP3K110.46412882
110CHUK0.45745187
111SCYL20.44091646
112ABL20.42780629
113ZAP700.42200737
114ITK0.41616849
115TRIM280.41582459
116PHKG10.41133769
117PHKG20.41133769
118GRK60.39560275
119TBK10.39455458
120CDK10.39393396
121LYN0.36779784
122KIT0.36162879
123IKBKE0.35289203
124PAK10.35158754
125DYRK1B0.34910000
126SYK0.34760523
127NEK10.34475936
128RAF10.33781040
129GRK10.33623725
130MARK10.32212844
131FLT30.30696484
132PRKAA10.29532128
133TNK20.28719154
134ERBB30.28045894
135PAK40.27975362
136SIK30.25481886
137MAP2K30.25052005
138MUSK0.24814121

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54741864
2RNA polymerase_Homo sapiens_hsa030203.84904129
3Mismatch repair_Homo sapiens_hsa034303.69107061
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63972113
5Ribosome_Homo sapiens_hsa030103.48603921
6Proteasome_Homo sapiens_hsa030503.33638841
7Homologous recombination_Homo sapiens_hsa034403.11353136
8Spliceosome_Homo sapiens_hsa030402.96144841
9Pyrimidine metabolism_Homo sapiens_hsa002402.84432512
10Base excision repair_Homo sapiens_hsa034102.80752153
11Fanconi anemia pathway_Homo sapiens_hsa034602.70501543
12RNA transport_Homo sapiens_hsa030132.58334773
13Nucleotide excision repair_Homo sapiens_hsa034202.55832000
14Cell cycle_Homo sapiens_hsa041102.28964411
15One carbon pool by folate_Homo sapiens_hsa006702.27935394
16Basal transcription factors_Homo sapiens_hsa030222.13499833
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00738443
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00149807
19RNA degradation_Homo sapiens_hsa030181.95598692
20Non-homologous end-joining_Homo sapiens_hsa034501.90345600
21Purine metabolism_Homo sapiens_hsa002301.66377682
22p53 signaling pathway_Homo sapiens_hsa041151.59594117
23mRNA surveillance pathway_Homo sapiens_hsa030151.34081786
24Alcoholism_Homo sapiens_hsa050341.24520062
25Herpes simplex infection_Homo sapiens_hsa051681.22075999
26Protein export_Homo sapiens_hsa030601.20588236
27Epstein-Barr virus infection_Homo sapiens_hsa051691.18629283
28Vitamin B6 metabolism_Homo sapiens_hsa007501.17214858
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12113275
30Fatty acid elongation_Homo sapiens_hsa000621.08657817
31Sulfur relay system_Homo sapiens_hsa041221.06447524
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06439892
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04736424
34Primary immunodeficiency_Homo sapiens_hsa053401.04363405
35Alzheimers disease_Homo sapiens_hsa050101.04036984
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02990362
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01905373
38Folate biosynthesis_Homo sapiens_hsa007900.99898264
39Propanoate metabolism_Homo sapiens_hsa006400.93554098
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92112569
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.89645292
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.87212029
43Sulfur metabolism_Homo sapiens_hsa009200.81331425
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80463586
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80305937
46Huntingtons disease_Homo sapiens_hsa050160.77893664
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77409397
48Measles_Homo sapiens_hsa051620.76895683
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.75700862
50Carbon metabolism_Homo sapiens_hsa012000.73592013
51Type I diabetes mellitus_Homo sapiens_hsa049400.73505732
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72247136
53Antigen processing and presentation_Homo sapiens_hsa046120.69584982
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.68862750
55Pentose phosphate pathway_Homo sapiens_hsa000300.67874500
56Arachidonic acid metabolism_Homo sapiens_hsa005900.65483570
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64896328
58Pyruvate metabolism_Homo sapiens_hsa006200.63819926
59Phototransduction_Homo sapiens_hsa047440.63595911
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63183430
61Systemic lupus erythematosus_Homo sapiens_hsa053220.62250114
62Cardiac muscle contraction_Homo sapiens_hsa042600.62194583
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.61171744
64HTLV-I infection_Homo sapiens_hsa051660.59269639
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57801053
66Parkinsons disease_Homo sapiens_hsa050120.57401110
67Other glycan degradation_Homo sapiens_hsa005110.56639507
68Allograft rejection_Homo sapiens_hsa053300.56054469
69Steroid biosynthesis_Homo sapiens_hsa001000.54403709
70Peroxisome_Homo sapiens_hsa041460.54007835
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52546753
72Oxidative phosphorylation_Homo sapiens_hsa001900.52506039
73Viral carcinogenesis_Homo sapiens_hsa052030.51918082
74Hematopoietic cell lineage_Homo sapiens_hsa046400.51591862
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51372435
76Legionellosis_Homo sapiens_hsa051340.51277987
77N-Glycan biosynthesis_Homo sapiens_hsa005100.51058932
78Regulation of autophagy_Homo sapiens_hsa041400.50944423
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50803778
80Thyroid cancer_Homo sapiens_hsa052160.50257810
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48472836
82Apoptosis_Homo sapiens_hsa042100.47712918
83Nitrogen metabolism_Homo sapiens_hsa009100.47629969
84Glutathione metabolism_Homo sapiens_hsa004800.47438784
85Influenza A_Homo sapiens_hsa051640.46155741
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44363510
87Butanoate metabolism_Homo sapiens_hsa006500.43955832
88Graft-versus-host disease_Homo sapiens_hsa053320.43523394
89Selenocompound metabolism_Homo sapiens_hsa004500.43318100
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43291545
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41730943
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.41494781
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40694405
94Autoimmune thyroid disease_Homo sapiens_hsa053200.38874152
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37437837
96Ether lipid metabolism_Homo sapiens_hsa005650.36557981
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36175812
98Asthma_Homo sapiens_hsa053100.35576390
99Leishmaniasis_Homo sapiens_hsa051400.34939616
100Metabolic pathways_Homo sapiens_hsa011000.34776770
101Small cell lung cancer_Homo sapiens_hsa052220.33713943
102Hepatitis B_Homo sapiens_hsa051610.33674707
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33182194
104Oocyte meiosis_Homo sapiens_hsa041140.32934742
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31916185
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31286876
107Linoleic acid metabolism_Homo sapiens_hsa005910.30480957
108Acute myeloid leukemia_Homo sapiens_hsa052210.30302589
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30259492
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.29557094
111Shigellosis_Homo sapiens_hsa051310.27929080
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27897100
113Galactose metabolism_Homo sapiens_hsa000520.27375822
114Vitamin digestion and absorption_Homo sapiens_hsa049770.26582167
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25752146
116Fructose and mannose metabolism_Homo sapiens_hsa000510.24917232
117T cell receptor signaling pathway_Homo sapiens_hsa046600.24865509
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24792029
119Olfactory transduction_Homo sapiens_hsa047400.22838485
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21953480
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21645076
122Arginine and proline metabolism_Homo sapiens_hsa003300.21490925
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20856914
124Biosynthesis of amino acids_Homo sapiens_hsa012300.20630178
125Fatty acid metabolism_Homo sapiens_hsa012120.20531896
126Sphingolipid metabolism_Homo sapiens_hsa006000.19927442
127MicroRNAs in cancer_Homo sapiens_hsa052060.17938145
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16813452
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16322832
130Notch signaling pathway_Homo sapiens_hsa043300.14671641
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10966900
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09702258
133Pathways in cancer_Homo sapiens_hsa052000.09242253

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »