NOBOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.97096011
2regulation of acrosome reaction (GO:0060046)8.52737150
3regulation of hypersensitivity (GO:0002883)7.75700305
4multicellular organism reproduction (GO:0032504)7.46835768
5DNA methylation involved in gamete generation (GO:0043046)6.94317450
6protein localization to kinetochore (GO:0034501)6.73145537
7mitotic metaphase plate congression (GO:0007080)6.48349299
8positive regulation of humoral immune response (GO:0002922)6.11454765
9mitotic chromosome condensation (GO:0007076)5.95288055
10positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.88023010
11regulation of meiosis (GO:0040020)5.82976840
12reproduction (GO:0000003)5.73259110
13regulation of phospholipid biosynthetic process (GO:0071071)5.65513850
14protein localization to chromosome, centromeric region (GO:0071459)5.56711234
15metaphase plate congression (GO:0051310)5.37216867
16negative regulation of meiosis (GO:0045835)5.34374596
17oocyte development (GO:0048599)5.24259403
18protein kinase C signaling (GO:0070528)5.20664409
19attachment of spindle microtubules to kinetochore (GO:0008608)5.19493195
20meiotic cell cycle (GO:0051321)5.13504797
21regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.08395871
22* female gamete generation (GO:0007292)5.02775571
23immunoglobulin mediated immune response (GO:0016064)5.00147008
24base-excision repair, AP site formation (GO:0006285)4.96291664
25male meiosis (GO:0007140)4.95695581
26endothelium development (GO:0003158)4.93248952
27negative regulation of reproductive process (GO:2000242)4.92810103
28establishment of chromosome localization (GO:0051303)4.85027318
29oocyte maturation (GO:0001556)4.71792993
30notochord development (GO:0030903)4.67897239
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.65798861
32citrulline biosynthetic process (GO:0019240)4.65636735
33regulation of exit from mitosis (GO:0007096)4.58990514
34regulation of meiotic cell cycle (GO:0051445)4.58772183
35protein localization to chromosome (GO:0034502)4.51375110
36histone H2A ubiquitination (GO:0033522)4.51331545
37regulation of sister chromatid cohesion (GO:0007063)4.51220572
38negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.50746215
39mitotic sister chromatid segregation (GO:0000070)4.48484532
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.48135675
41negative regulation of DNA-templated transcription, elongation (GO:0032785)4.48135675
42DNA alkylation (GO:0006305)4.47468300
43DNA methylation (GO:0006306)4.47468300
44negative regulation of meiotic cell cycle (GO:0051447)4.27146813
45histone H2A monoubiquitination (GO:0035518)4.24958439
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.21192456
47gene silencing by RNA (GO:0031047)4.20460567
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14665714
49binding of sperm to zona pellucida (GO:0007339)4.13461259
50regulation of meiosis I (GO:0060631)4.12958094
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.10855706
52microtubule severing (GO:0051013)4.09819498
53fertilization (GO:0009566)4.09674823
54positive regulation of chromosome segregation (GO:0051984)4.08227969
55single fertilization (GO:0007338)4.05311428
56negative regulation of smooth muscle cell differentiation (GO:0051151)4.02733050
57spindle checkpoint (GO:0031577)3.98840107
58regulation of DNA methylation (GO:0044030)3.96807868
59protein K6-linked ubiquitination (GO:0085020)3.85482150
60regulation of spindle organization (GO:0090224)3.84473911
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.83105135
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.83105135
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.83105135
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.82997885
65pyrimidine nucleotide catabolic process (GO:0006244)3.81871677
66regulation of mitotic spindle organization (GO:0060236)3.75951449
67regulation of transforming growth factor beta2 production (GO:0032909)3.73399029
68regulation of chromosome segregation (GO:0051983)3.67543875
69positive regulation of Cdc42 GTPase activity (GO:0043089)3.67203887
70B cell mediated immunity (GO:0019724)3.67060576
71interkinetic nuclear migration (GO:0022027)3.63196886
72sister chromatid segregation (GO:0000819)3.62097565
73DNA damage induced protein phosphorylation (GO:0006975)3.59495978
74regulation of retinoic acid receptor signaling pathway (GO:0048385)3.57865102
75negative regulation of chromosome segregation (GO:0051985)3.57457414
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.56143896
77negative regulation of sister chromatid segregation (GO:0033046)3.56143896
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.56143896
79negative regulation of mitotic sister chromatid segregation (GO:0033048)3.56143896
80mitotic spindle checkpoint (GO:0071174)3.54099028
81meiotic chromosome segregation (GO:0045132)3.53143485
82chaperone-mediated protein transport (GO:0072321)3.49453619
83mitotic spindle assembly checkpoint (GO:0007094)3.43516344
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40361895
85negative regulation of nuclear division (GO:0051784)3.40175464
86CENP-A containing nucleosome assembly (GO:0034080)3.39355391
87chromosome segregation (GO:0007059)3.38874102
88negative regulation of cell division (GO:0051782)3.38461827
89regulation of mitotic sister chromatid separation (GO:0010965)3.37356929
90regulation of mitotic sister chromatid segregation (GO:0033047)3.37356929
91regulation of sister chromatid segregation (GO:0033045)3.37356929
92glycerophospholipid catabolic process (GO:0046475)3.36536865
93spindle assembly checkpoint (GO:0071173)3.34319253
94maturation of 5.8S rRNA (GO:0000460)3.31535328
95histone exchange (GO:0043486)3.28458126
96regulation of RIG-I signaling pathway (GO:0039535)3.23366733
97DNA methylation or demethylation (GO:0044728)3.23020903
98chromatin remodeling at centromere (GO:0031055)3.20748396
99positive regulation of interleukin-4 production (GO:0032753)3.18661489
100regulation of female gonad development (GO:2000194)12.2858922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.05319937
2EZH2_22144423_ChIP-Seq_EOC_Human4.89635334
3E2F7_22180533_ChIP-Seq_HELA_Human4.30897804
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.21111871
5AR_21909140_ChIP-Seq_LNCAP_Human4.09420833
6SALL1_21062744_ChIP-ChIP_HESCs_Human4.05031935
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.61483363
8KAP1_22055183_ChIP-Seq_ESCs_Mouse3.29553003
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.59012988
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36648267
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26229312
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.07739500
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02707027
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99565999
15MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.96013958
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68779005
17MYC_18940864_ChIP-ChIP_HL60_Human1.58999098
18TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54994647
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54298800
20CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53379004
21RNF2_27304074_Chip-Seq_NSC_Mouse1.52592271
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49136156
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.48086245
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42538195
25RUNX1_26923725_Chip-Seq_HPCs_Mouse1.41357225
26GATA3_21867929_ChIP-Seq_TH1_Mouse1.39785831
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38223042
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37357174
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36417097
30NFYA_21822215_ChIP-Seq_K562_Human1.33291539
31STAT1_17558387_ChIP-Seq_HELA_Human1.31735855
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.30981398
33SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29974088
34* CDX2_22108803_ChIP-Seq_LS180_Human1.29841360
35AR_21572438_ChIP-Seq_LNCaP_Human1.29365883
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28046405
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25463543
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.25343449
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24413762
40STAT3_23295773_ChIP-Seq_U87_Human1.20838927
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20714900
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20101528
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17733533
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.17376103
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13353108
46CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11703057
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10998828
48TBL1_22424771_ChIP-Seq_293T_Human1.10386184
49IGF1R_20145208_ChIP-Seq_DFB_Human1.09880964
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08501611
51FUS_26573619_Chip-Seq_HEK293_Human1.08225330
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07706784
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.06991592
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06059661
55ETV1_20927104_ChIP-Seq_GIST48_Human1.05301233
56EWS_26573619_Chip-Seq_HEK293_Human1.04711835
57ESET_19884257_ChIP-Seq_ESCs_Mouse1.03691078
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02234957
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02088942
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00779486
61CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00717108
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98897686
63CTCF_18555785_Chip-Seq_ESCs_Mouse0.98666480
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98355380
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98261379
66SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97480475
67* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97353168
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97094277
69ERG_20517297_ChIP-Seq_VCAP_Human0.96045502
70* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95661157
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95282705
72NANOG_18555785_Chip-Seq_ESCs_Mouse0.94697639
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94444054
74NFE2_27457419_Chip-Seq_LIVER_Mouse0.94286000
75SMAD4_21741376_ChIP-Seq_EPCs_Human0.94050773
76STAT3_18555785_Chip-Seq_ESCs_Mouse0.93612390
77GF1B_26923725_Chip-Seq_HPCs_Mouse0.92680104
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.92316667
79SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92089370
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.90124614
81ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90064443
82KLF4_18555785_Chip-Seq_ESCs_Mouse0.89906653
83EP300_21415370_ChIP-Seq_HL-1_Mouse0.88442346
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87935058
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87881899
86NFYB_21822215_ChIP-Seq_K562_Human0.86221131
87ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86005717
88PHF8_20622853_ChIP-Seq_HELA_Human0.85948192
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85774650
90* KDM2B_26808549_Chip-Seq_REH_Human0.85721217
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85550808
92NMYC_18555785_Chip-Seq_ESCs_Mouse0.84013810
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83856475
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83537694
95RBPJ_21746931_ChIP-Seq_IB4_Human0.83107075
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.82939219
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82845829
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.82235449
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.81978078
100STAT1_20625510_ChIP-Seq_HELA_Human0.81952439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.52840535
2MP0008877_abnormal_DNA_methylation4.79923865
3MP0003646_muscle_fatigue4.12230863
4MP0005451_abnormal_body_composition4.03074249
5MP0010094_abnormal_chromosome_stability3.92866992
6MP0003693_abnormal_embryo_hatching3.75500361
7MP0005395_other_phenotype3.34698710
8* MP0003699_abnormal_female_reproductive3.30477399
9* MP0001119_abnormal_female_reproductive3.17160222
10MP0002102_abnormal_ear_morphology2.83236092
11MP0003111_abnormal_nucleus_morphology2.76751145
12MP0003077_abnormal_cell_cycle2.76102971
13MP0002295_abnormal_pulmonary_circulatio2.75550339
14* MP0001929_abnormal_gametogenesis2.72025334
15MP0003121_genomic_imprinting2.51614930
16MP0003787_abnormal_imprinting2.51193813
17* MP0000653_abnormal_sex_gland2.43359150
18MP0004957_abnormal_blastocyst_morpholog2.36411537
19MP0002210_abnormal_sex_determination2.23353155
20MP0001905_abnormal_dopamine_level2.20197335
21MP0006292_abnormal_olfactory_placode2.20024066
22MP0000579_abnormal_nail_morphology2.14085662
23MP0001919_abnormal_reproductive_system2.04910625
24MP0003123_paternal_imprinting2.00692853
25* MP0002161_abnormal_fertility/fecundity1.82556865
26MP0006072_abnormal_retinal_apoptosis1.80748890
27MP0000465_gastrointestinal_hemorrhage1.76464192
28MP0008932_abnormal_embryonic_tissue1.75611657
29MP0002653_abnormal_ependyma_morphology1.70190572
30MP0002249_abnormal_larynx_morphology1.65157325
31MP0004859_abnormal_synaptic_plasticity1.59929453
32MP0001529_abnormal_vocalization1.57870432
33MP0003329_amyloid_beta_deposits1.54017297
34MP0005389_reproductive_system_phenotype1.47876123
35MP0001145_abnormal_male_reproductive1.46329661
36MP0005408_hypopigmentation1.44321265
37MP0001915_intracranial_hemorrhage1.42099982
38MP0003937_abnormal_limbs/digits/tail_de1.41909754
39MP0003950_abnormal_plasma_membrane1.33119499
40MP0002932_abnormal_joint_morphology1.32708003
41MP0009384_cardiac_valve_regurgitation1.28363997
42MP0005360_urolithiasis1.27119083
43MP0008260_abnormal_autophagy1.22880752
44MP0000350_abnormal_cell_proliferation1.16915974
45MP0010386_abnormal_urinary_bladder1.14233707
46MP0001730_embryonic_growth_arrest1.11060360
47MP0002085_abnormal_embryonic_tissue1.10324306
48MP0005646_abnormal_pituitary_gland1.09899172
49MP0010368_abnormal_lymphatic_system1.07153313
50MP0004264_abnormal_extraembryonic_tissu1.04831102
51MP0005197_abnormal_uvea_morphology1.01091762
52MP0003315_abnormal_perineum_morphology0.99830408
53MP0003656_abnormal_erythrocyte_physiolo0.98279857
54MP0002019_abnormal_tumor_incidence0.96121445
55MP0005380_embryogenesis_phenotype0.94067894
56MP0001672_abnormal_embryogenesis/_devel0.94067894
57MP0003453_abnormal_keratinocyte_physiol0.93986412
58MP0001697_abnormal_embryo_size0.89346182
59MP0003698_abnormal_male_reproductive0.89065120
60MP0000639_abnormal_adrenal_gland0.87303563
61MP0002177_abnormal_outer_ear0.84693098
62MP0009697_abnormal_copulation0.80880473
63MP0002084_abnormal_developmental_patter0.79718626
64MP0000462_abnormal_digestive_system0.78919942
65MP0003763_abnormal_thymus_physiology0.77611940
66MP0008007_abnormal_cellular_replicative0.77029473
67MP0005310_abnormal_salivary_gland0.74899050
68MP0004782_abnormal_surfactant_physiolog0.71737327
69MP0001485_abnormal_pinna_reflex0.70721427
70MP0005621_abnormal_cell_physiology0.67807210
71MP0000604_amyloidosis0.67407367
72MP0008058_abnormal_DNA_repair0.67075572
73MP0004145_abnormal_muscle_electrophysio0.66356918
74MP0005023_abnormal_wound_healing0.65514077
75MP0000678_abnormal_parathyroid_gland0.64539343
76MP0002282_abnormal_trachea_morphology0.59416316
77MP0003755_abnormal_palate_morphology0.58535681
78MP0004484_altered_response_of0.57620801
79MP0000490_abnormal_crypts_of0.57488652
80MP0004270_analgesia0.56854064
81MP0005187_abnormal_penis_morphology0.56165335
82MP0004510_myositis0.56095484
83MP0004185_abnormal_adipocyte_glucose0.55931471
84MP0005384_cellular_phenotype0.54677311
85MP0002933_joint_inflammation0.54517649
86MP0000427_abnormal_hair_cycle0.54186182
87MP0002837_dystrophic_cardiac_calcinosis0.50102909
88MP0003632_abnormal_nervous_system0.49121337
89MP0000313_abnormal_cell_death0.48855896
90MP0003806_abnormal_nucleotide_metabolis0.47956964
91MP0002080_prenatal_lethality0.47823768
92MP0008057_abnormal_DNA_replication0.46954825
93MP0001346_abnormal_lacrimal_gland0.45372685
94MP0002269_muscular_atrophy0.45100488
95MP0002116_abnormal_craniofacial_bone0.44249214
96MP0003861_abnormal_nervous_system0.43834633
97MP0002168_other_aberrant_phenotype0.43791874
98MP0002736_abnormal_nociception_after0.43461164
99MP0010234_abnormal_vibrissa_follicle0.42557247
100MP0008875_abnormal_xenobiotic_pharmacok0.42291825

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.12960902
2Deep venous thrombosis (HP:0002625)6.33183887
3Cortical dysplasia (HP:0002539)5.91035883
4Infertility (HP:0000789)5.51507040
5Birth length less than 3rd percentile (HP:0003561)4.70699137
6Abnormality of the labia minora (HP:0012880)4.50868954
7Chromsome breakage (HP:0040012)4.42912846
8Papillary thyroid carcinoma (HP:0002895)4.36666347
9Flat capital femoral epiphysis (HP:0003370)4.35932127
10Secondary amenorrhea (HP:0000869)4.24013780
11Breast hypoplasia (HP:0003187)4.21709746
12Abnormality of chromosome segregation (HP:0002916)4.00302537
13Patellar aplasia (HP:0006443)3.96024676
14Rhabdomyosarcoma (HP:0002859)3.91482227
15Aplasia/Hypoplasia of the sternum (HP:0006714)3.80738223
16Shawl scrotum (HP:0000049)3.80395650
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79095280
18Facial hemangioma (HP:0000329)3.67820918
19Aplasia/Hypoplasia of the patella (HP:0006498)3.60690014
20Arterial tortuosity (HP:0005116)3.54781635
21Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.52459228
22Hypergonadotropic hypogonadism (HP:0000815)3.51717015
23Combined immunodeficiency (HP:0005387)3.43596575
24Insulin-resistant diabetes mellitus (HP:0000831)3.09565231
25Adrenal hypoplasia (HP:0000835)3.07403107
26Vascular tortuosity (HP:0004948)3.06588273
27Pulmonary fibrosis (HP:0002206)3.04736278
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.94541081
29Carpal bone hypoplasia (HP:0001498)2.91409927
30Spondylolisthesis (HP:0003302)2.90634183
31Neoplasm of striated muscle (HP:0009728)2.79506411
32Oligodactyly (hands) (HP:0001180)2.76304204
33Abnormal lung lobation (HP:0002101)2.69993886
34Atelectasis (HP:0100750)2.68992898
35Aplasia/Hypoplasia of the breasts (HP:0010311)2.67348936
36Sandal gap (HP:0001852)2.64857018
37Nephroblastoma (Wilms tumor) (HP:0002667)2.64111767
38Small intestinal stenosis (HP:0012848)2.58587858
39Duodenal stenosis (HP:0100867)2.58587858
40Breast aplasia (HP:0100783)2.58266909
41Impulsivity (HP:0100710)2.57264564
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53014828
43Cholecystitis (HP:0001082)2.52084244
44Abnormal gallbladder physiology (HP:0012438)2.52084244
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.49919538
46Capillary hemangiomas (HP:0005306)2.46689282
47Abnormality of cochlea (HP:0000375)2.46682244
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46382465
49Embryonal renal neoplasm (HP:0011794)2.45564150
50Fetal akinesia sequence (HP:0001989)2.45537179
51Supernumerary spleens (HP:0009799)2.43303233
52Uterine leiomyosarcoma (HP:0002891)2.40427241
53Leiomyosarcoma (HP:0100243)2.40427241
54Wrist flexion contracture (HP:0001239)2.39060930
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.36206524
56Hypoplasia of the fovea (HP:0007750)2.36206524
57Sloping forehead (HP:0000340)2.34796235
58Acute myeloid leukemia (HP:0004808)2.33097197
59Primary amenorrhea (HP:0000786)2.29977198
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.27990854
61Malnutrition (HP:0004395)2.27295544
62Oligodactyly (HP:0012165)2.26759420
63Abnormality of chromosome stability (HP:0003220)2.25872541
64Amniotic constriction ring (HP:0009775)2.24069487
65Abnormality of placental membranes (HP:0011409)2.24069487
66Overlapping toe (HP:0001845)2.23883084
67Abnormality of the fovea (HP:0000493)2.22029794
68Anterior segment dysgenesis (HP:0007700)2.21258391
69Hyperglycemia (HP:0003074)2.17650236
70Thyroid carcinoma (HP:0002890)2.12714663
71Irregular epiphyses (HP:0010582)2.11857747
72Abnormality of lateral ventricle (HP:0030047)2.10910017
73Villous atrophy (HP:0011473)2.10715340
74Abnormality of small intestinal villus morphology (HP:0011472)2.10715340
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09650534
76Abnormality of alanine metabolism (HP:0010916)2.09650534
77Hyperalaninemia (HP:0003348)2.09650534
78Abnormality of the femoral head (HP:0003368)2.09615310
79Abnormality of the fingertips (HP:0001211)2.09426067
80Absent radius (HP:0003974)2.07287212
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06753583
82Abnormality of femoral epiphyses (HP:0006499)2.05451474
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05451474
84Transitional cell carcinoma of the bladder (HP:0006740)2.04456329
85Chronic bronchitis (HP:0004469)1.99982625
86Absent forearm bone (HP:0003953)1.98767145
87Aplasia involving forearm bones (HP:0009822)1.98767145
88Abnormality of the duodenum (HP:0002246)1.96252756
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96164423
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.93547546
91Fibular aplasia (HP:0002990)1.92346912
92Apathy (HP:0000741)1.91301624
93Myelodysplasia (HP:0002863)1.90540273
94Arachnodactyly (HP:0001166)1.88830927
95Aplasia involving bones of the extremities (HP:0009825)1.85916810
96Aplasia involving bones of the upper limbs (HP:0009823)1.85916810
97Aplasia of the phalanges of the hand (HP:0009802)1.85916810
98Bladder carcinoma (HP:0002862)1.85911061
99Bladder neoplasm (HP:0009725)1.85911061
100Abnormality of the labia (HP:0000058)1.81627095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK5.04332980
2MAP3K64.57171713
3BRAF3.81553471
4TAOK33.60902688
5EEF2K3.49259427
6PLK43.47422371
7MOS3.34080539
8STK103.07755859
9MUSK3.02197690
10BMPR22.89611987
11ERBB42.86503394
12LATS22.69886644
13MAP3K92.61988701
14LATS12.51804631
15KSR22.45217981
16MAP3K132.30843248
17MAPKAPK32.04869724
18CDC71.97959290
19MELK1.92815383
20TAOK11.86474134
21CHEK21.77352059
22STK38L1.76815431
23ARAF1.66558134
24MAPKAPK51.65746744
25RAF11.61787768
26PLK11.59001936
27CDK81.53456690
28MAP3K81.41344742
29PRKD31.31876676
30MAPK131.31047003
31MAP3K41.22891664
32PAK61.14065326
33STK31.12909213
34CDK91.12659571
35NEK21.03720382
36AURKA1.02621908
37ACVR1B0.96545077
38EIF2AK10.90546337
39TRPM70.86706006
40KSR10.86373862
41AURKB0.83420326
42RET0.82003610
43MAP2K70.79185463
44BUB10.75037343
45CSNK1G10.74131906
46PRKD20.71509425
47DMPK0.68939865
48RPS6KB20.68431695
49PRKAA20.67399792
50NLK0.67356032
51TYRO30.66032248
52EPHA30.64698012
53PLK20.62650313
54LRRK20.60545425
55PRKAA10.58828631
56DYRK20.58433726
57CSNK1G30.52885015
58MAP2K40.49612500
59PLK30.47528199
60CSNK1G20.47208572
61NTRK20.46138144
62MARK20.45658873
63ATM0.43793780
64CHEK10.41980580
65NEK90.39256163
66EPHA40.38738627
67CSNK1A1L0.37817017
68NUAK10.37816570
69STK380.35628061
70MAP3K50.35346435
71ABL20.34530281
72CDK10.33834845
73STK240.33612845
74PINK10.29930811
75MAPK110.29786768
76MAP3K10.28349070
77CDK40.27581395
78BRSK20.27472264
79ABL10.26772759
80CAMK2A0.25210681
81CDK20.24357559
82BMPR1B0.23810860
83CSNK1D0.23521528
84BRSK10.23101896
85NTRK10.21879297
86PAK10.19140315
87ROCK10.18636854
88ROCK20.17255147
89AKT10.17145329
90NEK10.16147449
91CHUK0.13636241
92CDK70.13023744
93STK110.11470229
94SGK20.11189968
95MAPK10.10573664
96KIT0.09567149
97SGK2230.09526642
98SGK4940.09526642
99CDK30.09115781
100MAP2K10.08225017

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.43161602
2Cell cycle_Homo sapiens_hsa041104.21846140
3RNA degradation_Homo sapiens_hsa030183.77190674
4Basal transcription factors_Homo sapiens_hsa030223.43141366
5Vitamin B6 metabolism_Homo sapiens_hsa007503.21224846
6Homologous recombination_Homo sapiens_hsa034402.94542086
7Circadian rhythm_Homo sapiens_hsa047102.78232839
8Oocyte meiosis_Homo sapiens_hsa041142.62586263
9Fanconi anemia pathway_Homo sapiens_hsa034602.44207552
10Non-homologous end-joining_Homo sapiens_hsa034502.39117404
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.32068764
12Pancreatic cancer_Homo sapiens_hsa052122.26051230
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19261616
14Linoleic acid metabolism_Homo sapiens_hsa005912.09438431
15Ether lipid metabolism_Homo sapiens_hsa005652.06250145
16Base excision repair_Homo sapiens_hsa034101.83710280
17Mismatch repair_Homo sapiens_hsa034301.83543813
18Other glycan degradation_Homo sapiens_hsa005111.77996267
19Dorso-ventral axis formation_Homo sapiens_hsa043201.75827951
20p53 signaling pathway_Homo sapiens_hsa041151.68815393
21MicroRNAs in cancer_Homo sapiens_hsa052061.59683095
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59033254
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.55113265
24GnRH signaling pathway_Homo sapiens_hsa049121.53675602
25TGF-beta signaling pathway_Homo sapiens_hsa043501.53225460
26RNA transport_Homo sapiens_hsa030131.52915200
27DNA replication_Homo sapiens_hsa030301.45752428
28Prolactin signaling pathway_Homo sapiens_hsa049171.29502351
29Colorectal cancer_Homo sapiens_hsa052101.27513859
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17208573
31Nucleotide excision repair_Homo sapiens_hsa034201.14414927
32Choline metabolism in cancer_Homo sapiens_hsa052311.11419962
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10926620
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10517607
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00308706
36mRNA surveillance pathway_Homo sapiens_hsa030150.99952074
37Arginine biosynthesis_Homo sapiens_hsa002200.99790022
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93500659
39RNA polymerase_Homo sapiens_hsa030200.92761042
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.89270892
41VEGF signaling pathway_Homo sapiens_hsa043700.86652266
42Hippo signaling pathway_Homo sapiens_hsa043900.84322684
43FoxO signaling pathway_Homo sapiens_hsa040680.80007077
44Renal cell carcinoma_Homo sapiens_hsa052110.76405401
45Long-term depression_Homo sapiens_hsa047300.72143816
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71142352
47Adherens junction_Homo sapiens_hsa045200.70465704
48Ras signaling pathway_Homo sapiens_hsa040140.70163864
49Regulation of autophagy_Homo sapiens_hsa041400.68458616
50Purine metabolism_Homo sapiens_hsa002300.58990341
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.57732969
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57652303
53mTOR signaling pathway_Homo sapiens_hsa041500.57597955
54Complement and coagulation cascades_Homo sapiens_hsa046100.55960058
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54339649
56Estrogen signaling pathway_Homo sapiens_hsa049150.53382000
57Thyroid cancer_Homo sapiens_hsa052160.52109483
58Endometrial cancer_Homo sapiens_hsa052130.51107872
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50897039
60HTLV-I infection_Homo sapiens_hsa051660.50526947
61Notch signaling pathway_Homo sapiens_hsa043300.50161673
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49852672
63Inositol phosphate metabolism_Homo sapiens_hsa005620.49541189
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49466956
65Chronic myeloid leukemia_Homo sapiens_hsa052200.46845259
66Arginine and proline metabolism_Homo sapiens_hsa003300.46118459
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45171132
68Small cell lung cancer_Homo sapiens_hsa052220.44093691
69Lysine degradation_Homo sapiens_hsa003100.42052852
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41608838
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40865069
72Pyruvate metabolism_Homo sapiens_hsa006200.40117486
73Hepatitis B_Homo sapiens_hsa051610.39838448
74Glutamatergic synapse_Homo sapiens_hsa047240.38441887
75Hedgehog signaling pathway_Homo sapiens_hsa043400.37722981
76Arachidonic acid metabolism_Homo sapiens_hsa005900.37581158
77ErbB signaling pathway_Homo sapiens_hsa040120.34262147
78Non-small cell lung cancer_Homo sapiens_hsa052230.32526290
79Serotonergic synapse_Homo sapiens_hsa047260.31659143
80MAPK signaling pathway_Homo sapiens_hsa040100.30959258
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.30327983
82Pyrimidine metabolism_Homo sapiens_hsa002400.30141931
83Gap junction_Homo sapiens_hsa045400.27464382
84Folate biosynthesis_Homo sapiens_hsa007900.26830379
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26102724
86Amoebiasis_Homo sapiens_hsa051460.25647706
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25086181
88Glioma_Homo sapiens_hsa052140.24557851
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22138970
90Shigellosis_Homo sapiens_hsa051310.21762148
91cAMP signaling pathway_Homo sapiens_hsa040240.20953387
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20113856
93Oxytocin signaling pathway_Homo sapiens_hsa049210.19750986
94Sphingolipid metabolism_Homo sapiens_hsa006000.19445429
95Bladder cancer_Homo sapiens_hsa052190.18416482
96AMPK signaling pathway_Homo sapiens_hsa041520.17833537
97Pathways in cancer_Homo sapiens_hsa052000.15939255
98Prostate cancer_Homo sapiens_hsa052150.15176554
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14690287
100Wnt signaling pathway_Homo sapiens_hsa043100.14456218

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