ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-arginine omega-N-methylation (GO:0035247)	4.68965909
2	proteasome assembly (GO:0043248)	4.44055011
3	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.42890984
4	rRNA modification (GO:0000154)	4.37126540
5	proline biosynthetic process (GO:0006561)	4.04815671
6	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.99347120
7	histone arginine methylation (GO:0034969)	3.98326716
8	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.93139903
9	pseudouridine synthesis (GO:0001522)	3.87529062
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.86167172
11	peptidyl-arginine N-methylation (GO:0035246)	3.80670014
12	peptidyl-arginine methylation (GO:0018216)	3.80670014
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.79756790
14	ATP synthesis coupled proton transport (GO:0015986)	3.79756790
15	ribosome biogenesis (GO:0042254)	3.79751326
16	metallo-sulfur cluster assembly (GO:0031163)	3.73393588
17	iron-sulfur cluster assembly (GO:0016226)	3.73393588
18	mitochondrial RNA metabolic process (GO:0000959)	3.61180512
19	GDP-mannose metabolic process (GO:0019673)	3.55388409
20	ribosomal small subunit biogenesis (GO:0042274)	3.46962731
21	ribonucleoprotein complex biogenesis (GO:0022613)	3.45900445
22	guanosine-containing compound biosynthetic process (GO:1901070)	3.38870943
23	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.31652604
24	regulation of translational fidelity (GO:0006450)	3.30104458
25	transcription from mitochondrial promoter (GO:0006390)	3.27022588
26	male meiosis I (GO:0007141)	3.26376036
27	rRNA methylation (GO:0031167)	3.26039518
28	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.25692827
29	COPI coating of Golgi vesicle (GO:0048205)	3.24760069
30	Golgi transport vesicle coating (GO:0048200)	3.24760069
31	piRNA metabolic process (GO:0034587)	3.18096842
32	peptidyl-histidine modification (GO:0018202)	3.18033578
33	cellular component biogenesis (GO:0044085)	3.16917793
34	formation of translation preinitiation complex (GO:0001731)	3.12552703
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.08650371
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.08650371
37	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.06767889
38	mitochondrial fusion (GO:0008053)	3.05013337
39	7-methylguanosine mRNA capping (GO:0006370)	3.04340282
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02466154
41	NADH dehydrogenase complex assembly (GO:0010257)	3.02466154
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02466154
43	GMP metabolic process (GO:0046037)	3.00990699
44	protein targeting to mitochondrion (GO:0006626)	2.98312710
45	meiosis I (GO:0007127)	2.98125357
46	rRNA processing (GO:0006364)	2.96763247
47	DNA methylation involved in gamete generation (GO:0043046)	2.95868411
48	regulation of cellular amino acid metabolic process (GO:0006521)	2.95571413
49	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.95523225
50	chaperone-mediated protein transport (GO:0072321)	2.94843464
51	RNA capping (GO:0036260)	2.94481753
52	7-methylguanosine RNA capping (GO:0009452)	2.94481753
53	deoxyribose phosphate biosynthetic process (GO:0046385)	2.93851707
54	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.93851707
55	CTP metabolic process (GO:0046036)	2.93676148
56	CTP biosynthetic process (GO:0006241)	2.93676148
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93653960
58	spliceosomal snRNP assembly (GO:0000387)	2.93369852
59	pentose metabolic process (GO:0019321)	2.92024597
60	translation (GO:0006412)	2.91888704
61	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.91823662
62	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.91790472
63	oxidative phosphorylation (GO:0006119)	2.91575014
64	ncRNA 3-end processing (GO:0043628)	2.89777520
65	DNA strand elongation (GO:0022616)	2.89482457
66	protein complex biogenesis (GO:0070271)	2.88876244
67	ribosomal large subunit biogenesis (GO:0042273)	2.86454797
68	rRNA metabolic process (GO:0016072)	2.85625276
69	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.85056818
70	vagina development (GO:0060068)	2.84867144
71	GTP biosynthetic process (GO:0006183)	2.83698321
72	UTP biosynthetic process (GO:0006228)	2.81900865
73	tRNA aminoacylation (GO:0043039)	2.81095537
74	amino acid activation (GO:0043038)	2.81095537
75	establishment of protein localization to mitochondrion (GO:0072655)	2.80394154
76	DNA strand elongation involved in DNA replication (GO:0006271)	2.78342901
77	maturation of SSU-rRNA (GO:0030490)	2.77516532
78	tRNA methylation (GO:0030488)	2.77374922
79	electron transport chain (GO:0022900)	2.76089947
80	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.76038467
81	regulation of centriole replication (GO:0046599)	2.75427560
82	protein localization to mitochondrion (GO:0070585)	2.75274270
83	proline metabolic process (GO:0006560)	2.75164445
84	tRNA aminoacylation for protein translation (GO:0006418)	2.75017017
85	tRNA processing (GO:0008033)	2.74693781
86	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.73506293
87	negative regulation of ligase activity (GO:0051352)	2.73345205
88	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.73345205
89	regulation of cell proliferation involved in kidney development (GO:1901722)	2.72979125
90	translational elongation (GO:0006414)	2.72202048
91	tRNA metabolic process (GO:0006399)	2.71228657
92	resolution of meiotic recombination intermediates (GO:0000712)	2.70608413
93	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.70333560
94	transcription elongation from RNA polymerase II promoter (GO:0006368)	2.70291549
95	respiratory electron transport chain (GO:0022904)	2.69745597
96	regulation of spindle checkpoint (GO:0090231)	2.69141848
97	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.68834328
98	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.68220733
99	gonadal mesoderm development (GO:0007506)	2.67970004
100	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67727855

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.80563877
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.72263737
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65025615
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.57786490
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.47363575
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.47069309
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.13352434
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.11356147
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.10670124
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.99170938
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.97180916
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.94568486
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.91303129
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.82567413
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64229313
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57385713
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.56308389
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.51170956
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.46995229
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.46625732
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.36926534
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.23876463
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.21491730
24	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.19506778
25	DCP1A_22483619_ChIP-Seq_HELA_Human	2.17500413
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.16398553
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09546530
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08991905
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98406829
30	KDM5A_27292631_Chip-Seq_BREAST_Human	1.97813460
31	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.96501849
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.95250219
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.91773510
34	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.89806175
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.89483946
36	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.78619940
37	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.77951204
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77094902
39	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.72769756
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.70647873
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.68949087
42	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66872278
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.64575809
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61391639
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.58921579
46	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.54792147
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.53013506
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49279178
49	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.47634725
50	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.46440626
51	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.44110400
52	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.43522311
53	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.42577566
54	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.38292899
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32111182
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27369201
57	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.27041117
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26239126
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25898908
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25810489
61	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25656770
62	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.24069106
63	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.22971262
64	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.20080404
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19764034
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19381659
67	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.19180022
68	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.19108739
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.18456900
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16697872
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.16386953
72	RACK7_27058665_Chip-Seq_MCF-7_Human	1.14858947
73	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.12519601
74	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10762360
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.10087902
76	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10056478
77	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07580125
78	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.07538814
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07184478
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07003355
81	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05558138
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.05456564
83	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.04978048
84	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.04097338
85	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03371278
86	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.02470130
87	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01442368
88	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.01192784
89	TFEB_21752829_ChIP-Seq_HELA_Human	1.00149080
90	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97951751
91	P68_20966046_ChIP-Seq_HELA_Human	0.95793009
92	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.94698835
93	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94552438
94	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94324336
95	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.92772831
96	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92603760
97	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.92249479
98	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90136489
99	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.88344816
100	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.88276460

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.09388768
2	MP0008058_abnormal_DNA_repair	2.94666456
3	MP0004957_abnormal_blastocyst_morpholog	2.68079326
4	MP0005423_abnormal_somatic_nervous	2.67709776
5	MP0010094_abnormal_chromosome_stability	2.53913734
6	MP0003111_abnormal_nucleus_morphology	2.48666804
7	MP0003786_premature_aging	2.44218096
8	MP0005501_abnormal_skin_physiology	2.41469006
9	MP0002796_impaired_skin_barrier	2.37438657
10	MP0008932_abnormal_embryonic_tissue	2.32311239
11	MP0003077_abnormal_cell_cycle	2.03026132
12	MP0000750_abnormal_muscle_regeneration	2.00065588
13	MP0006035_abnormal_mitochondrial_morpho	1.95261925
14	MP0000372_irregular_coat_pigmentation	1.87403572
15	MP0001919_abnormal_reproductive_system	1.85938234
16	MP0001529_abnormal_vocalization	1.83653043
17	MP0009333_abnormal_splenocyte_physiolog	1.80537401
18	MP0002160_abnormal_reproductive_system	1.78758837
19	MP0003718_maternal_effect	1.72595750
20	MP0000678_abnormal_parathyroid_gland	1.72566948
21	MP0004147_increased_porphyrin_level	1.70281669
22	MP0002210_abnormal_sex_determination	1.68181119
23	MP0002098_abnormal_vibrissa_morphology	1.66512260
24	MP0008995_early_reproductive_senescence	1.64875185
25	MP0001873_stomach_inflammation	1.63790675
26	MP0003186_abnormal_redox_activity	1.62243428
27	MP0008877_abnormal_DNA_methylation	1.61153148
28	MP0001727_abnormal_embryo_implantation	1.58837232
29	MP0000462_abnormal_digestive_system	1.56344826
30	MP0004381_abnormal_hair_follicle	1.52501349
31	MP0000358_abnormal_cell_content/	1.50691869
32	MP0005075_abnormal_melanosome_morpholog	1.45505640
33	MP0001348_abnormal_lacrimal_gland	1.44150103
34	MP0001929_abnormal_gametogenesis	1.44141236
35	MP0006036_abnormal_mitochondrial_physio	1.39756920
36	MP0008260_abnormal_autophagy	1.39287784
37	MP0001730_embryonic_growth_arrest	1.37434945
38	MP0005394_taste/olfaction_phenotype	1.35376349
39	MP0005499_abnormal_olfactory_system	1.35376349
40	MP0008789_abnormal_olfactory_epithelium	1.35016313
41	MP0005076_abnormal_cell_differentiation	1.32465755
42	MP0002249_abnormal_larynx_morphology	1.28301039
43	MP0009672_abnormal_birth_weight	1.26045545
44	MP0001145_abnormal_male_reproductive	1.25868744
45	MP0000313_abnormal_cell_death	1.25712350
46	MP0010030_abnormal_orbit_morphology	1.24684066
47	MP0003123_paternal_imprinting	1.24225746
48	MP0001881_abnormal_mammary_gland	1.24031683
49	MP0010307_abnormal_tumor_latency	1.22788829
50	MP0005389_reproductive_system_phenotype	1.20714504
51	MP0003942_abnormal_urinary_system	1.18409692
52	MP0001697_abnormal_embryo_size	1.18380009
53	MP0002163_abnormal_gland_morphology	1.18003443
54	MP0000350_abnormal_cell_proliferation	1.14740622
55	MP0002080_prenatal_lethality	1.13588863
56	MP0000049_abnormal_middle_ear	1.11605053
57	MP0005408_hypopigmentation	1.09422900
58	MP0005083_abnormal_biliary_tract	1.07931497
59	MP0000427_abnormal_hair_cycle	1.07792865
60	MP0008007_abnormal_cellular_replicative	1.07491205
61	MP0000653_abnormal_sex_gland	1.07404030
62	MP0003698_abnormal_male_reproductive	1.06712858
63	MP0002938_white_spotting	1.06645281
64	MP0004264_abnormal_extraembryonic_tissu	1.05902335
65	MP0001984_abnormal_olfaction	1.05162073
66	MP0001986_abnormal_taste_sensitivity	1.04063849
67	MP0002736_abnormal_nociception_after	1.03630996
68	MP0002751_abnormal_autonomic_nervous	1.01462241
69	MP0001661_extended_life_span	0.98206098
70	MP0001188_hyperpigmentation	0.98070171
71	MP0000579_abnormal_nail_morphology	0.97035435
72	MP0010771_integument_phenotype	0.95827317
73	MP0002161_abnormal_fertility/fecundity	0.95695518
74	MP0003936_abnormal_reproductive_system	0.95683972
75	MP0009379_abnormal_foot_pigmentation	0.95594618
76	MP0000383_abnormal_hair_follicle	0.95010354
77	MP0003221_abnormal_cardiomyocyte_apopto	0.92115473
78	MP0005380_embryogenesis_phenotype	0.91556896
79	MP0001672_abnormal_embryogenesis/_devel	0.91556896
80	MP0004782_abnormal_surfactant_physiolog	0.90387330
81	MP0000490_abnormal_crypts_of	0.89632517
82	MP0004145_abnormal_muscle_electrophysio	0.88720439
83	MP0000627_abnormal_mammary_gland	0.88061400
84	MP0005410_abnormal_fertilization	0.87766876
85	MP0000377_abnormal_hair_follicle	0.87746163
86	MP0001293_anophthalmia	0.86732058
87	MP0006292_abnormal_olfactory_placode	0.85174870
88	MP0003937_abnormal_limbs/digits/tail_de	0.84675968
89	MP0002234_abnormal_pharynx_morphology	0.84156395
90	MP0000467_abnormal_esophagus_morphology	0.83908634
91	MP0003011_delayed_dark_adaptation	0.83111087
92	MP0003699_abnormal_female_reproductive	0.83018582
93	MP0002085_abnormal_embryonic_tissue	0.80829929
94	MP0008875_abnormal_xenobiotic_pharmacok	0.80559065
95	MP0004197_abnormal_fetal_growth/weight/	0.79311879
96	MP0009697_abnormal_copulation	0.77984208
97	MP0002184_abnormal_innervation	0.77560222
98	MP0001764_abnormal_homeostasis	0.73632280
99	MP0008872_abnormal_physiological_respon	0.73149320
100	MP0002088_abnormal_embryonic_growth/wei	0.73087982

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal pupillary function (HP:0007686)	4.91288408
2	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.09750261
3	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.09750261
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.90267280
5	Acute encephalopathy (HP:0006846)	3.61887919
6	Acute necrotizing encephalopathy (HP:0006965)	3.60131112
7	Concave nail (HP:0001598)	3.54149488
8	Abnormality of glycolysis (HP:0004366)	3.50993985
9	Increased intramyocellular lipid droplets (HP:0012240)	3.45529765
10	Increased serum pyruvate (HP:0003542)	3.43222588
11	Septate vagina (HP:0001153)	3.29320689
12	Mitochondrial inheritance (HP:0001427)	3.26325115
13	Microvesicular hepatic steatosis (HP:0001414)	3.11460832
14	Increased CSF lactate (HP:0002490)	3.07635380
15	Increased serum lactate (HP:0002151)	3.05928641
16	Hepatocellular necrosis (HP:0001404)	3.02742188
17	Syringomyelia (HP:0003396)	3.02274012
18	Spinal cord lesions (HP:0100561)	3.02274012
19	Increased muscle lipid content (HP:0009058)	2.87363960
20	Ragged-red muscle fibers (HP:0003200)	2.86130421
21	Spastic paraparesis (HP:0002313)	2.80943020
22	Entropion (HP:0000621)	2.80271761
23	Hepatic necrosis (HP:0002605)	2.76301272
24	Lactic acidosis (HP:0003128)	2.74603158
25	Progressive macrocephaly (HP:0004481)	2.71927397
26	Cutaneous melanoma (HP:0012056)	2.71671078
27	Cholecystitis (HP:0001082)	2.67143577
28	Abnormal gallbladder physiology (HP:0012438)	2.67143577
29	Abnormality of cells of the erythroid lineage (HP:0012130)	2.63512005
30	Microretrognathia (HP:0000308)	2.61227012
31	Testicular atrophy (HP:0000029)	2.59476764
32	Cerebral edema (HP:0002181)	2.56430251
33	J-shaped sella turcica (HP:0002680)	2.50731974
34	Progressive muscle weakness (HP:0003323)	2.50058988
35	Poor speech (HP:0002465)	2.38596038
36	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.37623407
37	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.31973891
38	Exercise intolerance (HP:0003546)	2.30228643
39	Increased hepatocellular lipid droplets (HP:0006565)	2.29809670
40	Progressive microcephaly (HP:0000253)	2.26200009
41	Microglossia (HP:0000171)	2.24974335
42	Atresia of the external auditory canal (HP:0000413)	2.19228388
43	Sensory axonal neuropathy (HP:0003390)	2.18347507
44	Poikiloderma (HP:0001029)	2.15539653
45	Rough bone trabeculation (HP:0100670)	2.14566843
46	Hypoplasia of the pons (HP:0012110)	2.14027821
47	Absent thumb (HP:0009777)	2.11827644
48	Renal Fanconi syndrome (HP:0001994)	2.11570523
49	Reticulocytosis (HP:0001923)	2.10992916
50	Lethargy (HP:0001254)	2.10423602
51	Abnormal number of erythroid precursors (HP:0012131)	2.08904554
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08304897
53	Degeneration of anterior horn cells (HP:0002398)	2.07548993
54	Abnormality of the anterior horn cell (HP:0006802)	2.07548993
55	Abnormality of reticulocytes (HP:0004312)	2.07535938
56	Hypoparathyroidism (HP:0000829)	2.05901923
57	Lipid accumulation in hepatocytes (HP:0006561)	2.04548699
58	Meningioma (HP:0002858)	2.04205524
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03937952
60	Abnormality of alanine metabolism (HP:0010916)	2.03937952
61	Hyperalaninemia (HP:0003348)	2.03937952
62	Reticulocytopenia (HP:0001896)	2.00237874
63	Abnormality of the pons (HP:0007361)	1.99633260
64	Unilateral renal agenesis (HP:0000122)	1.98939720
65	Melanoma (HP:0002861)	1.97092512
66	Ulnar claw (HP:0001178)	1.96077154
67	Congenital ichthyosiform erythroderma (HP:0007431)	1.94841929
68	Dysautonomia (HP:0002459)	1.92912007
69	Congenital malformation of the right heart (HP:0011723)	1.92742497
70	Double outlet right ventricle (HP:0001719)	1.92742497
71	Respiratory failure (HP:0002878)	1.92146211
72	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.91459914
73	Cholelithiasis (HP:0001081)	1.90871779
74	Brittle hair (HP:0002299)	1.88847943
75	Amelogenesis imperfecta (HP:0000705)	1.85805745
76	Premature ovarian failure (HP:0008209)	1.85745878
77	Type I transferrin isoform profile (HP:0003642)	1.84899397
78	Chromsome breakage (HP:0040012)	1.82977776
79	Abnormal gallbladder morphology (HP:0012437)	1.82067974
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81123900
81	Poor suck (HP:0002033)	1.80612009
82	Abnormality of the umbilical cord (HP:0010881)	1.80401615
83	Squamous cell carcinoma (HP:0002860)	1.79730422
84	Abnormality of the preputium (HP:0100587)	1.79201045
85	Birth length less than 3rd percentile (HP:0003561)	1.78902303
86	Truncus arteriosus (HP:0001660)	1.78856903
87	Cleft eyelid (HP:0000625)	1.78360350
88	Abnormal protein glycosylation (HP:0012346)	1.77851717
89	Abnormal glycosylation (HP:0012345)	1.77851717
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77851717
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.77851717
92	Abnormality of DNA repair (HP:0003254)	1.76806874
93	Scrotal hypoplasia (HP:0000046)	1.76198218
94	Abnormality of the fetal cardiovascular system (HP:0010948)	1.75841387
95	Abnormal umbilical cord blood vessels (HP:0011403)	1.75841387
96	Single umbilical artery (HP:0001195)	1.75841387
97	Pili torti (HP:0003777)	1.75839039
98	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74948125
99	Hyperthyroidism (HP:0000836)	1.74911971
100	Opisthotonus (HP:0002179)	1.70692490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	3.51267529
2	STK16	3.23367448
3	TESK2	3.22042093
4	NME2	3.16355940
5	BUB1	3.03071575
6	PIK3CA	2.73269073
7	VRK2	2.66620567
8	MAPKAPK3	2.64288017
9	TSSK6	2.45322425
10	SRPK1	2.38862087
11	RPS6KB2	2.32701588
12	MAP2K2	2.30895211
13	DYRK3	2.19151427
14	PBK	2.15634109
15	BCKDK	2.08683506
16	TESK1	2.05502371
17	MUSK	2.03749071
18	PKN2	2.00184876
19	EPHA2	1.99031450
20	ZAK	1.98318712
21	TRIM28	1.80386309
22	SCYL2	1.73773388
23	PIM2	1.73013331
24	PRKD3	1.56185549
25	NEK1	1.54365175
26	TTK	1.54038877
27	ILK	1.51773486
28	IRAK3	1.48822800
29	NUAK1	1.47932086
30	SIK1	1.47595777
31	SMG1	1.47458927
32	EIF2AK1	1.46546286
33	LIMK1	1.34059564
34	AURKA	1.32218145
35	NME1	1.26511778
36	PRKCI	1.22500016
37	WNK3	1.14323995
38	CDK7	1.10917271
39	PDK2	1.06794284
40	MAP4K2	1.05606162
41	BRAF	0.99220624
42	MST4	0.98511359
43	GRK6	0.98104180
44	EEF2K	0.96440724
45	PLK1	0.96108351
46	CDC7	0.94705739
47	IKBKB	0.93508142
48	VRK1	0.93239147
49	CHEK2	0.91679408
50	NEK6	0.91236875
51	PLK4	0.85785385
52	ARAF	0.85612660
53	AURKB	0.85381716
54	CHUK	0.82218072
55	AKT2	0.81468304
56	CDK8	0.81041452
57	CASK	0.72503329
58	MAP3K9	0.69759398
59	ATR	0.68767444
60	CHEK1	0.68582177
61	TLK1	0.68541665
62	CAMK2G	0.67994326
63	CLK1	0.67009116
64	TBK1	0.66827786
65	RPS6KA4	0.66553283
66	DAPK1	0.65336436
67	MAP2K1	0.63168380
68	LRRK2	0.61478025
69	PAK4	0.61143525
70	PTK6	0.61055733
71	PLK3	0.60643859
72	CAMK2B	0.60427030
73	WNK4	0.57813013
74	BRSK1	0.55665638
75	EIF2AK2	0.50889503
76	CSNK2A1	0.50520140
77	CAMK2D	0.49731255
78	RPS6KA5	0.49333640
79	TAOK2	0.48292122
80	STK4	0.47841233
81	CSNK2A2	0.47246673
82	PAK1	0.45686216
83	RPS6KA2	0.45398397
84	MAPKAPK2	0.45040613
85	MAP2K7	0.43673830
86	MAP3K11	0.43080308
87	MAP3K8	0.41557923
88	WEE1	0.40848140
89	RPS6KA1	0.38254676
90	DYRK2	0.35448309
91	CDK1	0.34786145
92	CSNK1G3	0.34540685
93	PASK	0.33916390
94	RAF1	0.33717048
95	KDR	0.33048391
96	RPS6KB1	0.32976904
97	MTOR	0.31607798
98	STK39	0.31503359
99	PRKD2	0.30049286
100	PHKG2	0.29197992

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.50728842
2	Proteasome_Homo sapiens_hsa03050	3.37886620
3	Ribosome_Homo sapiens_hsa03010	3.30660209
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89531504
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.81372728
6	DNA replication_Homo sapiens_hsa03030	2.70779463
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.59752324
8	RNA polymerase_Homo sapiens_hsa03020	2.54346363
9	Parkinsons disease_Homo sapiens_hsa05012	2.43097417
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.38719476
11	Base excision repair_Homo sapiens_hsa03410	2.37710226
12	Mismatch repair_Homo sapiens_hsa03430	2.37005222
13	Homologous recombination_Homo sapiens_hsa03440	2.18324084
14	Protein export_Homo sapiens_hsa03060	2.07891936
15	Basal transcription factors_Homo sapiens_hsa03022	2.04640425
16	Spliceosome_Homo sapiens_hsa03040	1.99912592
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99745298
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.99558813
19	RNA transport_Homo sapiens_hsa03013	1.96369025
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86005598
21	Huntingtons disease_Homo sapiens_hsa05016	1.84294121
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.83908188
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67162015
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55867723
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.48797574
26	Alzheimers disease_Homo sapiens_hsa05010	1.47907500
27	Fatty acid elongation_Homo sapiens_hsa00062	1.45648482
28	One carbon pool by folate_Homo sapiens_hsa00670	1.42844671
29	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38110180
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34378718
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.32087077
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30229035
33	Sulfur metabolism_Homo sapiens_hsa00920	1.27220364
34	Folate biosynthesis_Homo sapiens_hsa00790	1.25866780
35	RNA degradation_Homo sapiens_hsa03018	1.22805183
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.19630606
37	Pentose phosphate pathway_Homo sapiens_hsa00030	1.19334845
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.13667507
39	Cell cycle_Homo sapiens_hsa04110	1.09401332
40	Purine metabolism_Homo sapiens_hsa00230	1.09171942
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03528718
42	Carbon metabolism_Homo sapiens_hsa01200	1.00685018
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00246791
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.96140542
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.92970932
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.86710206
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.83196601
48	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82162009
49	Regulation of autophagy_Homo sapiens_hsa04140	0.80041260
50	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79577916
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78654285
52	Metabolic pathways_Homo sapiens_hsa01100	0.77919937
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.76669721
54	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.75949501
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74249012
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70898045
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70412236
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68656236
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.64254427
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63575053
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63050219
62	p53 signaling pathway_Homo sapiens_hsa04115	0.61984635
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61647622
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59380813
65	Peroxisome_Homo sapiens_hsa04146	0.56862472
66	Glutathione metabolism_Homo sapiens_hsa00480	0.52657459
67	Oocyte meiosis_Homo sapiens_hsa04114	0.52274939
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51357234
69	Thyroid cancer_Homo sapiens_hsa05216	0.51337380
70	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49054535
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47301085
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44694790
73	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43565530
74	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42699124
75	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.42567714
76	Bladder cancer_Homo sapiens_hsa05219	0.42459269
77	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.41902855
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41345984
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40832778
80	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37634985
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.34979290
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34346667
83	Galactose metabolism_Homo sapiens_hsa00052	0.32277934
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31814943
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.30481155
86	Endometrial cancer_Homo sapiens_hsa05213	0.30151380
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.29594332
88	Apoptosis_Homo sapiens_hsa04210	0.26493304
89	mTOR signaling pathway_Homo sapiens_hsa04150	0.26395238
90	Acute myeloid leukemia_Homo sapiens_hsa05221	0.23248240
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.22644879
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19602612
93	Propanoate metabolism_Homo sapiens_hsa00640	0.19077828
94	Alcoholism_Homo sapiens_hsa05034	0.18011062
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.17376251
96	Butanoate metabolism_Homo sapiens_hsa00650	0.15682101
97	Melanoma_Homo sapiens_hsa05218	0.13516551
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.13437524
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.12632633
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.11308794

NOC2LP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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