NOC4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.17352258
2DNA deamination (GO:0045006)5.04851921
3telomere maintenance via semi-conservative replication (GO:0032201)4.97688212
4DNA strand elongation (GO:0022616)4.92980710
5DNA replication initiation (GO:0006270)4.90492442
6maturation of SSU-rRNA (GO:0030490)4.64108592
7ribosomal small subunit assembly (GO:0000028)4.51953260
8nucleobase biosynthetic process (GO:0046112)4.44710250
9peptidyl-arginine omega-N-methylation (GO:0035247)4.39697428
10telomere maintenance via recombination (GO:0000722)4.36640513
11DNA unwinding involved in DNA replication (GO:0006268)4.35642298
12DNA replication checkpoint (GO:0000076)4.28587568
13protein maturation by protein folding (GO:0022417)4.25553246
14formation of translation preinitiation complex (GO:0001731)4.17879145
15purine nucleobase biosynthetic process (GO:0009113)4.05596652
16mitotic recombination (GO:0006312)4.05004077
17regulation of mitochondrial translation (GO:0070129)4.02528340
18histone arginine methylation (GO:0034969)3.98395815
19protein localization to kinetochore (GO:0034501)3.92412685
20telomere maintenance via telomere lengthening (GO:0010833)3.91694299
21IMP biosynthetic process (GO:0006188)3.88721338
22ribosomal large subunit biogenesis (GO:0042273)3.84767821
23mitotic metaphase plate congression (GO:0007080)3.84581792
24viral transcription (GO:0019083)3.84014109
25CENP-A containing nucleosome assembly (GO:0034080)3.83934131
26folic acid-containing compound biosynthetic process (GO:0009396)3.82965421
27* ribosome biogenesis (GO:0042254)3.81173882
28mitotic nuclear envelope disassembly (GO:0007077)3.81140028
29translational termination (GO:0006415)3.78662598
30chromatin remodeling at centromere (GO:0031055)3.76655050
31* ribonucleoprotein complex biogenesis (GO:0022613)3.73863281
32proteasome assembly (GO:0043248)3.71249020
33ribosomal small subunit biogenesis (GO:0042274)3.69498411
34peptidyl-arginine N-methylation (GO:0035246)3.69434988
35peptidyl-arginine methylation (GO:0018216)3.69434988
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.68581556
37ribosome assembly (GO:0042255)3.66584000
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.65312028
39pseudouridine synthesis (GO:0001522)3.61765863
40translational elongation (GO:0006414)3.57179493
41translational initiation (GO:0006413)3.52864102
42* rRNA processing (GO:0006364)3.52371081
43protein localization to chromosome, centromeric region (GO:0071459)3.52300391
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.51974125
45DNA replication-independent nucleosome organization (GO:0034724)3.51847717
46DNA replication-independent nucleosome assembly (GO:0006336)3.51847717
47spliceosomal snRNP assembly (GO:0000387)3.51049787
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50137225
49membrane disassembly (GO:0030397)3.49819253
50nuclear envelope disassembly (GO:0051081)3.49819253
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.49066691
52IMP metabolic process (GO:0046040)3.47974511
53protein targeting to mitochondrion (GO:0006626)3.47103590
54pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.45625317
55DNA replication-dependent nucleosome assembly (GO:0006335)3.44956758
56DNA replication-dependent nucleosome organization (GO:0034723)3.44956758
57rRNA modification (GO:0000154)3.41924297
58* rRNA metabolic process (GO:0016072)3.40191748
59GDP-mannose metabolic process (GO:0019673)3.37753563
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36075263
61nuclear envelope reassembly (GO:0031468)3.35156516
62mitotic nuclear envelope reassembly (GO:0007084)3.35156516
63guanosine-containing compound biosynthetic process (GO:1901070)3.34902206
64regulation of translational fidelity (GO:0006450)3.34834358
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.34237540
66metaphase plate congression (GO:0051310)3.31202338
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29600103
68rRNA transcription (GO:0009303)3.27946024
69establishment of viral latency (GO:0019043)3.26422054
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24867004
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24779624
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24581549
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23946782
74transcription-coupled nucleotide-excision repair (GO:0006283)3.23597562
75attachment of spindle microtubules to kinetochore (GO:0008608)3.21521667
76folic acid metabolic process (GO:0046655)3.21371991
77proline biosynthetic process (GO:0006561)3.20711969
782-deoxyribonucleotide biosynthetic process (GO:0009265)3.20705946
79deoxyribose phosphate biosynthetic process (GO:0046385)3.20705946
80oxidative phosphorylation (GO:0006119)3.20631883
81nucleobase-containing small molecule interconversion (GO:0015949)3.20347633
82kinetochore organization (GO:0051383)3.17678042
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17646026
84transcription from mitochondrial promoter (GO:0006390)3.17634722
85cotranslational protein targeting to membrane (GO:0006613)3.14680303
86histone exchange (GO:0043486)3.14470236
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.14436943
88establishment of protein localization to mitochondrion (GO:0072655)3.13835049
89nucleotide salvage (GO:0043173)3.13808327
90protein targeting to ER (GO:0045047)3.13402001
91chaperone-mediated protein transport (GO:0072321)3.12642836
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10888480
93pentose-phosphate shunt (GO:0006098)3.10549882
94maturation of 5.8S rRNA (GO:0000460)3.09075360
95UTP biosynthetic process (GO:0006228)3.08785123
96pentose metabolic process (GO:0019321)3.08607410
97negative regulation of B cell apoptotic process (GO:0002903)3.08302975
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.07907657
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07907657
100G1/S transition of mitotic cell cycle (GO:0000082)3.06011659
101cell cycle G1/S phase transition (GO:0044843)3.06011659
102mitotic sister chromatid segregation (GO:0000070)3.05120732
103nuclear pore organization (GO:0006999)3.04409044
104deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.02579406
105establishment of chromosome localization (GO:0051303)3.01679094
106protein localization to mitochondrion (GO:0070585)3.01353101
107cellular protein complex disassembly (GO:0043624)3.00724395
108regulation of spindle organization (GO:0090224)3.00579648
109spliceosomal complex assembly (GO:0000245)2.99982747
110kinetochore assembly (GO:0051382)2.99672801
111purine nucleotide salvage (GO:0032261)2.99299823
112telomere organization (GO:0032200)2.98721723
113metallo-sulfur cluster assembly (GO:0031163)2.98235469
114iron-sulfur cluster assembly (GO:0016226)2.98235469
115telomere maintenance (GO:0000723)2.97191857
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.97151466
117viral life cycle (GO:0019058)2.96667041
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96105319
119negative regulation of ligase activity (GO:0051352)2.96105319
120protein localization to endoplasmic reticulum (GO:0070972)2.95795728
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95675661
122regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94813073
123peptidyl-histidine modification (GO:0018202)2.93665216
124translation (GO:0006412)2.93568812
125DNA duplex unwinding (GO:0032508)2.92126170
126establishment of integrated proviral latency (GO:0075713)2.91952558
127viral mRNA export from host cell nucleus (GO:0046784)2.91737409
128mitotic chromosome condensation (GO:0007076)2.91180678
129DNA geometric change (GO:0032392)2.89895268
130NADPH regeneration (GO:0006740)2.88215415
131mitochondrial fusion (GO:0008053)2.88189189
132* cellular component biogenesis (GO:0044085)2.87317527
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.87028319
134termination of RNA polymerase III transcription (GO:0006386)2.86541757
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.86541757
136CTP metabolic process (GO:0046036)2.86295080
137CTP biosynthetic process (GO:0006241)2.86295080
138negative regulation of RNA splicing (GO:0033119)2.85584842
139pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.85119872
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.84482190
141negative regulation of mRNA processing (GO:0050686)2.83380238
142mismatch repair (GO:0006298)2.83197822
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83081776
144pyrimidine nucleotide catabolic process (GO:0006244)2.82257176
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80115467
146negative regulation of chromosome segregation (GO:0051985)2.79657626
147base-excision repair (GO:0006284)2.79574734
148RNA splicing, via transesterification reactions (GO:0000375)2.79407843
149mRNA splicing, via spliceosome (GO:0000398)2.78951752
150RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78951752
151termination of RNA polymerase I transcription (GO:0006363)2.78838762
152tRNA aminoacylation for protein translation (GO:0006418)2.78227035
153regulation of translational termination (GO:0006449)2.77508328
154deoxyribonucleotide catabolic process (GO:0009264)2.76954331
155tRNA methylation (GO:0030488)2.76356643
156COPI coating of Golgi vesicle (GO:0048205)2.76343018
157Golgi transport vesicle coating (GO:0048200)2.76343018
158protein complex localization (GO:0031503)2.76070508
159heterochromatin organization (GO:0070828)2.75874975
160negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.75677174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07122776
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38523486
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99931804
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.61099199
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37712165
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.35893967
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25914500
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06654584
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.04407641
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98639636
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93956039
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93366285
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.92899669
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.92862210
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83555218
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65452820
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58996015
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54494489
19XRN2_22483619_ChIP-Seq_HELA_Human2.36540775
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30070975
21* VDR_23849224_ChIP-Seq_CD4+_Human2.28218192
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25338229
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22103283
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10588215
25DCP1A_22483619_ChIP-Seq_HELA_Human2.06973666
26FOXP3_21729870_ChIP-Seq_TREG_Human2.06149159
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03190907
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98232774
29GABP_19822575_ChIP-Seq_HepG2_Human1.97899876
30AR_21909140_ChIP-Seq_LNCAP_Human1.90832456
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88616293
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.88102379
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84850978
34* TTF2_22483619_ChIP-Seq_HELA_Human1.82536667
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82240687
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81648442
37CIITA_25753668_ChIP-Seq_RAJI_Human1.80233449
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.77636732
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76374918
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72192614
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71195580
42MYC_22102868_ChIP-Seq_BL_Human1.70854139
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70428316
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70073573
45ZNF263_19887448_ChIP-Seq_K562_Human1.64994071
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63374262
47LXR_22292898_ChIP-Seq_THP-1_Human1.61724427
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61423968
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.58243164
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.53897308
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53785136
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.53147220
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.52628026
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52535650
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52301363
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51947662
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48678465
58ELK1_19687146_ChIP-ChIP_HELA_Human1.48381215
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.48040558
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47610029
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45703170
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44376900
63KDM5A_27292631_Chip-Seq_BREAST_Human1.40461204
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39733334
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36011077
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32636457
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32205192
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31687606
69P68_20966046_ChIP-Seq_HELA_Human1.31512596
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27334730
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.25962648
72RACK7_27058665_Chip-Seq_MCF-7_Human1.23006279
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22375415
74VDR_21846776_ChIP-Seq_THP-1_Human1.22218194
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21310319
76* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21000646
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20509907
78* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17085326
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16813438
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16227781
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15018782
82* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14888857
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13835576
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13168580
85TFEB_21752829_ChIP-Seq_HELA_Human1.13163463
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12861132
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10766359
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.10528191
89* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10304685
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09889395
91BCL6_27268052_Chip-Seq_Bcells_Human1.06247029
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04612820
93MAF_26560356_Chip-Seq_TH2_Human1.04606680
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.04590542
95SPI1_23547873_ChIP-Seq_NB4_Human1.04530725
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03669564
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03439733
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03249780
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02893925
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00264602
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00032135
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.99743070
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99409394
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99405420
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97357215
106MYC_18940864_ChIP-ChIP_HL60_Human0.96809225
107BCOR_27268052_Chip-Seq_Bcells_Human0.96730856
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93118842
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91617390
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91349210
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91021751
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90638173
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88951302
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.88023250
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87451391
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86647016
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86600989
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81317229
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80943604
120FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80640143
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79382130
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77785662
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77658130
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75274541
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74231705
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.70968551
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70312263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81063315
2MP0010094_abnormal_chromosome_stability4.83108557
3MP0003111_abnormal_nucleus_morphology4.67587928
4MP0004957_abnormal_blastocyst_morpholog4.57950661
5MP0008057_abnormal_DNA_replication4.09676828
6MP0003077_abnormal_cell_cycle4.05132621
7MP0005451_abnormal_body_composition4.00647644
8MP0008058_abnormal_DNA_repair3.71237656
9MP0008007_abnormal_cellular_replicative3.10668898
10MP0002396_abnormal_hematopoietic_system3.01781005
11MP0008932_abnormal_embryonic_tissue2.62668410
12MP0005058_abnormal_lysosome_morphology2.53314620
13MP0001730_embryonic_growth_arrest2.20902319
14MP0000490_abnormal_crypts_of2.15498300
15MP0003786_premature_aging2.13110307
16MP0004233_abnormal_muscle_weight2.12422312
17MP0000350_abnormal_cell_proliferation2.11930092
18MP0002877_abnormal_melanocyte_morpholog2.10859808
19MP0000678_abnormal_parathyroid_gland2.02338020
20MP0003763_abnormal_thymus_physiology1.95321611
21MP0003123_paternal_imprinting1.93776591
22MP0008877_abnormal_DNA_methylation1.89896485
23MP0010352_gastrointestinal_tract_polyps1.88914362
24MP0009333_abnormal_splenocyte_physiolog1.80866907
25MP0003806_abnormal_nucleotide_metabolis1.72782164
26MP0003718_maternal_effect1.72614920
27MP0005501_abnormal_skin_physiology1.72162816
28MP0009278_abnormal_bone_marrow1.68989477
29MP0004858_abnormal_nervous_system1.67211498
30MP0005397_hematopoietic_system_phenotyp1.66256187
31MP0001545_abnormal_hematopoietic_system1.66256187
32MP0004808_abnormal_hematopoietic_stem1.65008919
33MP0010307_abnormal_tumor_latency1.63129286
34MP0002019_abnormal_tumor_incidence1.62009428
35MP0001849_ear_inflammation1.57898180
36MP0000313_abnormal_cell_death1.57210313
37MP0001672_abnormal_embryogenesis/_devel1.54186885
38MP0005380_embryogenesis_phenotype1.54186885
39MP0002080_prenatal_lethality1.53834476
40MP0001697_abnormal_embryo_size1.51348454
41MP0002398_abnormal_bone_marrow1.49825720
42MP0004185_abnormal_adipocyte_glucose1.46929532
43MP0000703_abnormal_thymus_morphology1.42142853
44MP0002722_abnormal_immune_system1.39690367
45MP0003984_embryonic_growth_retardation1.37651724
46MP0000689_abnormal_spleen_morphology1.36020907
47MP0002796_impaired_skin_barrier1.34878952
48MP0002088_abnormal_embryonic_growth/wei1.33480735
49MP0002085_abnormal_embryonic_tissue1.24965969
50MP0002163_abnormal_gland_morphology1.24664742
51MP0002210_abnormal_sex_determination1.22808794
52MP0002132_abnormal_respiratory_system1.21489599
53MP0003315_abnormal_perineum_morphology1.19816075
54MP0001853_heart_inflammation1.19210322
55MP0002429_abnormal_blood_cell1.18086627
56MP0001661_extended_life_span1.16862056
57MP0005075_abnormal_melanosome_morpholog1.15091424
58MP0002086_abnormal_extraembryonic_tissu1.12086669
59MP0005670_abnormal_white_adipose1.11536107
60MP0005671_abnormal_response_to1.11501875
61MP0000358_abnormal_cell_content/1.10513939
62MP0003186_abnormal_redox_activity1.06532086
63MP0006054_spinal_hemorrhage1.06510040
64MP0000716_abnormal_immune_system1.06010487
65MP0001145_abnormal_male_reproductive1.05481237
66MP0002084_abnormal_developmental_patter1.04795257
67MP0003567_abnormal_fetal_cardiomyocyte1.03738326
68MP0009840_abnormal_foam_cell1.03257844
69MP0001835_abnormal_antigen_presentation1.03200758
70MP0005330_cardiomyopathy1.02896064
71MP0004147_increased_porphyrin_level1.02800534
72MP0006292_abnormal_olfactory_placode1.02066704
73MP0001929_abnormal_gametogenesis1.01485994
74MP0006036_abnormal_mitochondrial_physio0.98895610
75MP0000858_altered_metastatic_potential0.98321378
76MP0002249_abnormal_larynx_morphology0.96757584
77MP0000750_abnormal_muscle_regeneration0.96615278
78MP0001727_abnormal_embryo_implantation0.96536384
79MP0000685_abnormal_immune_system0.95660919
80MP0003656_abnormal_erythrocyte_physiolo0.95485540
81MP0004197_abnormal_fetal_growth/weight/0.94905688
82MP0001800_abnormal_humoral_immune0.94695737
83MP0006035_abnormal_mitochondrial_morpho0.93846216
84MP0009672_abnormal_birth_weight0.92852744
85MP0003453_abnormal_keratinocyte_physiol0.92838114
86MP0000653_abnormal_sex_gland0.92370811
87MP0000003_abnormal_adipose_tissue0.90413552
88MP0000537_abnormal_urethra_morphology0.88943423
89MP0002420_abnormal_adaptive_immunity0.88296243
90MP0001188_hyperpigmentation0.88254650
91MP0001881_abnormal_mammary_gland0.87833697
92MP0005666_abnormal_adipose_tissue0.87586297
93MP0001819_abnormal_immune_cell0.86763660
94MP0002405_respiratory_system_inflammati0.86580881
95MP0001119_abnormal_female_reproductive0.85517031
96MP0005623_abnormal_meninges_morphology0.83603081
97MP0005375_adipose_tissue_phenotype0.83505814
98MP0005384_cellular_phenotype0.82174649
99MP0009379_abnormal_foot_pigmentation0.82068620
100MP0003436_decreased_susceptibility_to0.81694298
101MP0003221_abnormal_cardiomyocyte_apopto0.81104773
102MP0002452_abnormal_antigen_presenting0.81062105
103MP0003705_abnormal_hypodermis_morpholog0.80852488
104MP0002723_abnormal_immune_serum0.80689166
105MP0005394_taste/olfaction_phenotype0.80319934
106MP0005499_abnormal_olfactory_system0.80319934
107MP0002160_abnormal_reproductive_system0.80300963
108MP0003172_abnormal_lysosome_physiology0.79429545
109MP0001293_anophthalmia0.79098751
110MP0009785_altered_susceptibility_to0.78117695
111MP0000681_abnormal_thyroid_gland0.76612566
112MP0005621_abnormal_cell_physiology0.75540181
113MP0010155_abnormal_intestine_physiology0.74774700
114MP0005389_reproductive_system_phenotype0.73185175
115MP0000049_abnormal_middle_ear0.72897078
116MP0008260_abnormal_autophagy0.72637285
117MP0000465_gastrointestinal_hemorrhage0.72514005
118MP0000343_altered_response_to0.71746810
119MP0005025_abnormal_response_to0.70971485
120MP0000477_abnormal_intestine_morphology0.70846095
121MP0003890_abnormal_embryonic-extraembry0.70691997
122MP0002095_abnormal_skin_pigmentation0.70515344
123MP0003121_genomic_imprinting0.69089969
124MP0005174_abnormal_tail_pigmentation0.69088785
125MP0002970_abnormal_white_adipose0.65999398
126MP0008789_abnormal_olfactory_epithelium0.65364373
127MP0003866_abnormal_defecation0.64719739
128MP0009931_abnormal_skin_appearance0.63800826
129MP0005000_abnormal_immune_tolerance0.63339057
130MP0001919_abnormal_reproductive_system0.61831356
131MP0005266_abnormal_metabolism0.61447827
132MP0000759_abnormal_skeletal_muscle0.61187503
133MP0008873_increased_physiological_sensi0.61159498
134MP0004133_heterotaxia0.61080041
135MP0001764_abnormal_homeostasis0.59632620
136MP0001873_stomach_inflammation0.57037451
137MP0002653_abnormal_ependyma_morphology0.56702642
138MP0005023_abnormal_wound_healing0.55567909
139MP0005076_abnormal_cell_differentiation0.53920055
140MP0010030_abnormal_orbit_morphology0.53573067

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98744587
2Abnormal number of erythroid precursors (HP:0012131)4.76681964
3Abnormality of cells of the erythroid lineage (HP:0012130)4.71739184
4Reticulocytopenia (HP:0001896)4.45862887
5Oral leukoplakia (HP:0002745)4.07993733
6Aplastic anemia (HP:0001915)3.92667349
7Ragged-red muscle fibers (HP:0003200)3.76655497
8Breast hypoplasia (HP:0003187)3.66541659
9Abnormal gallbladder physiology (HP:0012438)3.59496365
10Cholecystitis (HP:0001082)3.59496365
11Chromsome breakage (HP:0040012)3.39802715
12Rough bone trabeculation (HP:0100670)3.39313179
13Selective tooth agenesis (HP:0001592)3.36159363
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27840534
15Abnormality of the preputium (HP:0100587)3.23630628
16Abnormality of the anterior horn cell (HP:0006802)3.23233562
17Degeneration of anterior horn cells (HP:0002398)3.23233562
18Broad distal phalanx of finger (HP:0009836)3.19825984
19Abnormal mitochondria in muscle tissue (HP:0008316)3.18664752
20Carpal bone hypoplasia (HP:0001498)3.13968015
21Cerebral hypomyelination (HP:0006808)3.12380156
22Medulloblastoma (HP:0002885)3.08764483
23Macrocytic anemia (HP:0001972)3.06589905
24Patellar aplasia (HP:0006443)3.06311761
25Colon cancer (HP:0003003)3.04887896
26Meckel diverticulum (HP:0002245)3.04663138
27Agnosia (HP:0010524)3.02375165
28Pallor (HP:0000980)3.01287178
29Testicular atrophy (HP:0000029)2.98986745
30Increased intramyocellular lipid droplets (HP:0012240)2.98347481
31Abnormality of chromosome stability (HP:0003220)2.93302091
32Abnormality of the ileum (HP:0001549)2.91919307
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89836743
34Microretrognathia (HP:0000308)2.89206952
35Hepatocellular necrosis (HP:0001404)2.88684570
36Increased muscle lipid content (HP:0009058)2.85204999
37Aplasia/Hypoplasia of the patella (HP:0006498)2.85035691
38Absent thumb (HP:0009777)2.84590050
39Ependymoma (HP:0002888)2.84457097
40Thrombocytosis (HP:0001894)2.79445966
41Premature graying of hair (HP:0002216)2.77197090
42Acute necrotizing encephalopathy (HP:0006965)2.76088693
43Bone marrow hypocellularity (HP:0005528)2.75262233
44Myelodysplasia (HP:0002863)2.75073613
45Mitochondrial inheritance (HP:0001427)2.73417718
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.73186236
47Hypertensive crisis (HP:0100735)2.71205552
48Abnormality of glycolysis (HP:0004366)2.70580163
49Type I transferrin isoform profile (HP:0003642)2.69465563
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.65083478
51Truncus arteriosus (HP:0001660)2.62309320
52Increased CSF lactate (HP:0002490)2.59702821
53Acute encephalopathy (HP:0006846)2.54119469
54Rhabdomyosarcoma (HP:0002859)2.50877358
55Small intestinal stenosis (HP:0012848)2.50098332
56Duodenal stenosis (HP:0100867)2.50098332
57Trismus (HP:0000211)2.48745465
5811 pairs of ribs (HP:0000878)2.48574856
59Myopathic facies (HP:0002058)2.46561191
60Neoplasm of the pancreas (HP:0002894)2.44076219
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43309211
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43309211
63Pancytopenia (HP:0001876)2.42929118
64Hepatic necrosis (HP:0002605)2.42644795
65Abnormal trabecular bone morphology (HP:0100671)2.41867097
66Premature ovarian failure (HP:0008209)2.41365470
67Impulsivity (HP:0100710)2.38431590
68Lactic acidosis (HP:0003128)2.36433618
69IgM deficiency (HP:0002850)2.36248676
70Lymphoma (HP:0002665)2.34642391
71Cellular immunodeficiency (HP:0005374)2.34623084
72Exercise intolerance (HP:0003546)2.33848783
73Respiratory difficulties (HP:0002880)2.29775556
74Basal cell carcinoma (HP:0002671)2.27592465
75Obstructive lung disease (HP:0006536)2.26714728
76Chronic obstructive pulmonary disease (HP:0006510)2.26714728
77Absent radius (HP:0003974)2.26619119
78Muscle fiber atrophy (HP:0100295)2.26448960
79Amaurosis fugax (HP:0100576)2.26431074
80Increased serum lactate (HP:0002151)2.25836732
81Renal Fanconi syndrome (HP:0001994)2.24065724
82Multiple enchondromatosis (HP:0005701)2.21476758
83Progressive external ophthalmoplegia (HP:0000590)2.20391174
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19362425
85Achilles tendon contracture (HP:0001771)2.19036436
86Sloping forehead (HP:0000340)2.18744084
87Cleft eyelid (HP:0000625)2.17863778
88Microvesicular hepatic steatosis (HP:0001414)2.16346905
89Hyperthyroidism (HP:0000836)2.15153127
90Hyperacusis (HP:0010780)2.14914528
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14280033
92Tracheoesophageal fistula (HP:0002575)2.14137646
93Increased serum pyruvate (HP:0003542)2.13816160
94Reduced antithrombin III activity (HP:0001976)2.11440941
95Type 2 muscle fiber atrophy (HP:0003554)2.11406133
96Horseshoe kidney (HP:0000085)2.09883167
97Poikiloderma (HP:0001029)2.09517381
98Megaloblastic anemia (HP:0001889)2.07851328
99Absent forearm bone (HP:0003953)2.07483349
100Aplasia involving forearm bones (HP:0009822)2.07483349
101Progressive muscle weakness (HP:0003323)2.07361318
102Triphalangeal thumb (HP:0001199)2.06969839
103Emotional lability (HP:0000712)2.06805634
104Abnormality of reticulocytes (HP:0004312)2.06299269
105Secondary amenorrhea (HP:0000869)2.05498376
106Increased hepatocellular lipid droplets (HP:0006565)2.04698279
107Long palpebral fissure (HP:0000637)2.03586140
108Abnormal number of incisors (HP:0011064)2.03050163
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02877107
110Abnormality of the duodenum (HP:0002246)2.02795713
111Hypergonadotropic hypogonadism (HP:0000815)2.01825726
112Pulmonary fibrosis (HP:0002206)2.01630106
113Seborrheic dermatitis (HP:0001051)2.01541259
114Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01317840
115Abnormality of the umbilical cord (HP:0010881)1.99271539
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.96470281
117Cerebral edema (HP:0002181)1.96256092
118Prolonged neonatal jaundice (HP:0006579)1.95954457
119Abnormal lung lobation (HP:0002101)1.95439571
120Reticulocytosis (HP:0001923)1.95142417
121Abnormality of DNA repair (HP:0003254)1.94964899
122Abnormality of pyrimidine metabolism (HP:0004353)1.94764507
123Upper limb muscle weakness (HP:0003484)1.94401859
124Fasciculations (HP:0002380)1.94350805
125Cholelithiasis (HP:0001081)1.92889890
126Abnormal protein glycosylation (HP:0012346)1.92880515
127Abnormal glycosylation (HP:0012345)1.92880515
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92880515
129Abnormal protein N-linked glycosylation (HP:0012347)1.92880515
130Abnormality of the tricuspid valve (HP:0001702)1.92624869
131Distal upper limb amyotrophy (HP:0007149)1.91762604
132Upper limb amyotrophy (HP:0009129)1.91762604
133Hypokinesia (HP:0002375)1.91524814
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.91138864
135Clubbing of toes (HP:0100760)1.90822186
136Lipid accumulation in hepatocytes (HP:0006561)1.89437859
137Ectopic kidney (HP:0000086)1.87469070
138Supernumerary spleens (HP:0009799)1.87102878
139Squamous cell carcinoma (HP:0002860)1.87045900
140Abnormal spermatogenesis (HP:0008669)1.86651418
141Sparse eyelashes (HP:0000653)1.86598432
142Vertebral compression fractures (HP:0002953)1.85339012
143Poor head control (HP:0002421)1.81114756
144Slender long bone (HP:0003100)1.80342707
145Dicarboxylic aciduria (HP:0003215)1.79637208
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79637208
147Abnormality of the carotid arteries (HP:0005344)1.79189005
148Aplasia/Hypoplasia of the thymus (HP:0010515)1.78570433
149Abnormality of the gallbladder (HP:0005264)1.77400200
150Hypoplasia of the pons (HP:0012110)1.77146470
151Abnormality of the Achilles tendon (HP:0005109)1.77043661
152Progressive macrocephaly (HP:0004481)1.76992551
153Nonimmune hydrops fetalis (HP:0001790)1.76886981
154Entropion (HP:0000621)1.76697042
155Cafe-au-lait spot (HP:0000957)1.76281647
156Neoplasm of the colon (HP:0100273)1.75955467
157Atresia of the external auditory canal (HP:0000413)1.75805277
158Death in infancy (HP:0001522)1.75266820
159Petechiae (HP:0000967)1.74321179
160Delusions (HP:0000746)1.73907442
161Hepatosplenomegaly (HP:0001433)1.73509132
162Abnormal umbilical cord blood vessels (HP:0011403)1.72759219
163Single umbilical artery (HP:0001195)1.72759219
164Abnormality of the fetal cardiovascular system (HP:0010948)1.72759219
165Opisthotonus (HP:0002179)1.71298528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.96904379
2WEE14.36460821
3VRK23.84823673
4EIF2AK13.76241033
5CDC73.49306957
6SMG13.29193239
7STK162.85796939
8NME22.54857057
9NEK22.53270819
10TSSK62.42671521
11ERN12.40642798
12EIF2AK32.19296978
13ACVR1B2.17728884
14SRPK12.11623514
15PLK42.11129236
16TTK2.07024562
17TESK22.04188033
18NEK11.95100668
19BRSK21.92826644
20ARAF1.92211474
21PLK11.85457390
22TRIB31.82233747
23VRK11.81200138
24EEF2K1.71218038
25CDK71.64802872
26RPS6KB21.58268868
27ATR1.54350792
28AURKB1.53254700
29ICK1.52826005
30MAP4K11.52173595
31RPS6KA41.49718962
32BRSK11.48536479
33MKNK11.43105491
34PIM21.42680949
35PASK1.41655297
36DYRK31.40875149
37TLK11.39493134
38PRPF4B1.36450607
39SCYL21.35218746
40SIK11.32835109
41STK101.32253223
42AURKA1.29530401
43CDK41.28472393
44MST1R1.27478953
45MAP3K81.26826243
46CHEK21.25387712
47CCNB11.25350827
48PLK31.18908124
49KDR1.18391445
50MKNK21.17971916
51FLT31.15646035
52CSNK1G31.11045338
53TGFBR11.08144929
54CHEK11.04455028
55TESK11.00623015
56MAP3K110.97879218
57IRAK30.94276811
58EPHA20.94256666
59MAPKAPK30.93678623
60MAP3K30.88126277
61PAK40.87123601
62TAOK10.84560525
63CDK80.83620317
64PIM10.83596388
65MAP3K100.82750802
66PDK20.81519530
67ZAP700.81071161
68STK40.80555654
69CDK120.79404827
70LIMK10.78277568
71BRAF0.75020732
72EIF2AK20.71864996
73TBK10.71803294
74TEC0.71563721
75NME10.70972274
76ZAK0.70336068
77CSNK1A1L0.68710669
78CDK20.68638355
79BTK0.68616891
80IRAK40.68448452
81PAK10.67847231
82ATM0.66052974
83CSNK2A10.65871666
84TAF10.65695241
85CSNK2A20.65192701
86PRKD30.64809060
87TAOK20.64204756
88DAPK30.63540755
89IRAK20.60778335
90MAP2K30.58845683
91BLK0.56860666
92LRRK20.56760561
93CSNK1G10.55905269
94BCKDK0.55387200
95PRKCI0.55066371
96KIT0.54638424
97PKN20.53575160
98JAK30.53173070
99CSNK1G20.51058586
100MAP3K10.50830466
101TXK0.50469489
102BMX0.50169285
103NLK0.47906440
104CLK10.46980017
105CDK90.45728207
106CDK10.44720711
107DAPK10.44178701
108PBK0.43932014
109CDK11A0.41095074
110RAF10.40665232
111ALK0.40145881
112MELK0.39715520
113RPS6KA50.39712462
114GRK60.38538147
115MTOR0.38185665
116TTN0.37330610
117RPS6KL10.36854751
118RPS6KC10.36854751
119SIK30.36268665
120RPS6KA10.35232487
121MAP2K20.35229081
122CSF1R0.34704937
123DYRK20.33082222
124PDK30.30186885
125PDK40.30186885
126MAPK110.30048758
127AKT20.29375410
128TYK20.28866195
129IKBKB0.28723425
130ILK0.27207944
131SYK0.26678839
132LYN0.25592629
133CDK190.25040122
134ABL20.22578444

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29827748
2Mismatch repair_Homo sapiens_hsa034304.33284025
3Ribosome_Homo sapiens_hsa030103.61628173
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54226413
5Proteasome_Homo sapiens_hsa030503.41151453
6Base excision repair_Homo sapiens_hsa034103.30167257
7RNA polymerase_Homo sapiens_hsa030203.25997425
8Spliceosome_Homo sapiens_hsa030403.17874821
9Homologous recombination_Homo sapiens_hsa034403.04150314
10RNA transport_Homo sapiens_hsa030132.89883247
11Nucleotide excision repair_Homo sapiens_hsa034202.89155173
12One carbon pool by folate_Homo sapiens_hsa006702.68927358
13Pyrimidine metabolism_Homo sapiens_hsa002402.63157887
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50675755
15Cell cycle_Homo sapiens_hsa041102.47725736
16Fanconi anemia pathway_Homo sapiens_hsa034602.15639702
17Non-homologous end-joining_Homo sapiens_hsa034501.94786688
18RNA degradation_Homo sapiens_hsa030181.84303603
19Basal transcription factors_Homo sapiens_hsa030221.80633126
20p53 signaling pathway_Homo sapiens_hsa041151.45689312
21Purine metabolism_Homo sapiens_hsa002301.41547907
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40211629
23mRNA surveillance pathway_Homo sapiens_hsa030151.38390036
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35492581
25Epstein-Barr virus infection_Homo sapiens_hsa051691.17309140
26Other glycan degradation_Homo sapiens_hsa005111.09559609
27Fatty acid elongation_Homo sapiens_hsa000621.07430916
28Pentose phosphate pathway_Homo sapiens_hsa000301.05141177
29Folate biosynthesis_Homo sapiens_hsa007901.04070088
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03881613
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.01781292
32Sulfur relay system_Homo sapiens_hsa041221.01030312
33Herpes simplex infection_Homo sapiens_hsa051680.99095208
34Alzheimers disease_Homo sapiens_hsa050100.98337997
35Antigen processing and presentation_Homo sapiens_hsa046120.98285855
36Biosynthesis of amino acids_Homo sapiens_hsa012300.97312147
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.96665847
38Vibrio cholerae infection_Homo sapiens_hsa051100.94616387
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87869879
40Primary immunodeficiency_Homo sapiens_hsa053400.85659508
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84834319
42Selenocompound metabolism_Homo sapiens_hsa004500.84388189
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81637690
44Pyruvate metabolism_Homo sapiens_hsa006200.79874124
45Protein export_Homo sapiens_hsa030600.78434194
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.75723623
47Viral carcinogenesis_Homo sapiens_hsa052030.75701650
48Systemic lupus erythematosus_Homo sapiens_hsa053220.74363923
49Vitamin B6 metabolism_Homo sapiens_hsa007500.73263574
50Phenylalanine metabolism_Homo sapiens_hsa003600.72477757
51Oocyte meiosis_Homo sapiens_hsa041140.71755149
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68852201
53HTLV-I infection_Homo sapiens_hsa051660.66098370
54Legionellosis_Homo sapiens_hsa051340.64273879
55Thyroid cancer_Homo sapiens_hsa052160.64192929
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63864134
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61308847
58N-Glycan biosynthesis_Homo sapiens_hsa005100.58199443
59Huntingtons disease_Homo sapiens_hsa050160.57951379
60Measles_Homo sapiens_hsa051620.57554853
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56625314
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55409505
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.55222621
64Sulfur metabolism_Homo sapiens_hsa009200.54198311
65Carbon metabolism_Homo sapiens_hsa012000.53990869
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53657922
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51058862
68Fructose and mannose metabolism_Homo sapiens_hsa000510.50974142
69Lysosome_Homo sapiens_hsa041420.46832590
70Glutathione metabolism_Homo sapiens_hsa004800.46211995
71Steroid biosynthesis_Homo sapiens_hsa001000.45960706
72Apoptosis_Homo sapiens_hsa042100.45920394
73Parkinsons disease_Homo sapiens_hsa050120.44363881
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.42386110
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42360350
76Salmonella infection_Homo sapiens_hsa051320.40885448
77Shigellosis_Homo sapiens_hsa051310.37742037
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37545510
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37471892
80Small cell lung cancer_Homo sapiens_hsa052220.35902960
81Pancreatic cancer_Homo sapiens_hsa052120.35628132
82Galactose metabolism_Homo sapiens_hsa000520.35050365
83Hepatitis B_Homo sapiens_hsa051610.34507013
84Hematopoietic cell lineage_Homo sapiens_hsa046400.33889943
85Allograft rejection_Homo sapiens_hsa053300.33806184
86Acute myeloid leukemia_Homo sapiens_hsa052210.33448610
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32291226
88Influenza A_Homo sapiens_hsa051640.31459943
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.31020971
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30724872
91Arginine and proline metabolism_Homo sapiens_hsa003300.30316434
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29754349
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29570656
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29266451
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29064236
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28830432
97Colorectal cancer_Homo sapiens_hsa052100.27863473
98Metabolic pathways_Homo sapiens_hsa011000.26499187
99HIF-1 signaling pathway_Homo sapiens_hsa040660.24912568
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24325788
101MicroRNAs in cancer_Homo sapiens_hsa052060.23934428
102Non-small cell lung cancer_Homo sapiens_hsa052230.23544682
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23394962
104Fatty acid metabolism_Homo sapiens_hsa012120.22468574
105Prion diseases_Homo sapiens_hsa050200.21663762
106Leishmaniasis_Homo sapiens_hsa051400.20655268
107Oxidative phosphorylation_Homo sapiens_hsa001900.20412047
108Tyrosine metabolism_Homo sapiens_hsa003500.20246321
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20213385
110Asthma_Homo sapiens_hsa053100.19513466
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.18065469
112Collecting duct acid secretion_Homo sapiens_hsa049660.17660506
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17072729
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.16935897
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16421709
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15801618
117Regulation of autophagy_Homo sapiens_hsa041400.15782188
118Notch signaling pathway_Homo sapiens_hsa043300.14467309
119Bladder cancer_Homo sapiens_hsa052190.12480496
120Renin-angiotensin system_Homo sapiens_hsa046140.11107856
121T cell receptor signaling pathway_Homo sapiens_hsa046600.11055202
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10995019
123Viral myocarditis_Homo sapiens_hsa054160.09902730
124Chronic myeloid leukemia_Homo sapiens_hsa052200.09478339
125Graft-versus-host disease_Homo sapiens_hsa053320.08130293
126Arachidonic acid metabolism_Homo sapiens_hsa005900.07541248

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