NOCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coronary vasculature morphogenesis (GO:0060977)7.50508975
2regulation of secondary heart field cardioblast proliferation (GO:0003266)6.20618059
3regulation of cardioblast proliferation (GO:0003264)6.20618059
4exogenous drug catabolic process (GO:0042738)6.02278765
5sympathetic nervous system development (GO:0048485)5.71671480
6negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.64247999
7cartilage morphogenesis (GO:0060536)5.48383327
8cardiac ventricle formation (GO:0003211)5.39412237
9positive regulation of transcription regulatory region DNA binding (GO:2000679)5.29704807
10enteric nervous system development (GO:0048484)5.15939952
11developmental pigmentation (GO:0048066)5.05929604
12cardiac chamber formation (GO:0003207)4.87876378
13regulation of vitamin D biosynthetic process (GO:0060556)4.76998980
14kynurenine metabolic process (GO:0070189)4.76719472
15drug catabolic process (GO:0042737)4.70506650
16behavioral response to nicotine (GO:0035095)4.60796563
17branching involved in labyrinthine layer morphogenesis (GO:0060670)4.57623818
18cellular response to ATP (GO:0071318)4.48847451
19pre-miRNA processing (GO:0031054)4.47008476
20indole-containing compound catabolic process (GO:0042436)4.46980451
21indolalkylamine catabolic process (GO:0046218)4.46980451
22tryptophan catabolic process (GO:0006569)4.46980451
23negative regulation of striated muscle cell apoptotic process (GO:0010664)4.41625997
24tyrosine metabolic process (GO:0006570)4.40731982
25sexual reproduction (GO:0019953)4.28829092
26DNA deamination (GO:0045006)4.25121503
27regulation of chronic inflammatory response (GO:0002676)4.25067846
28positive regulation of heat generation (GO:0031652)4.16971856
29fucose catabolic process (GO:0019317)4.11979093
30L-fucose metabolic process (GO:0042354)4.11979093
31L-fucose catabolic process (GO:0042355)4.11979093
32peripheral nervous system neuron development (GO:0048935)4.08994444
33tongue development (GO:0043586)4.06601615
34positive regulation of cell size (GO:0045793)3.97018876
35dopaminergic neuron differentiation (GO:0071542)3.95993644
36apoptotic process involved in morphogenesis (GO:0060561)3.95293575
37negative regulation of mast cell activation (GO:0033004)3.94315690
38nuclear pore complex assembly (GO:0051292)3.92087341
39suckling behavior (GO:0001967)3.84308851
40cell migration involved in heart development (GO:0060973)3.81187350
41regulation of cardiac muscle cell apoptotic process (GO:0010665)3.80227781
42phenol-containing compound biosynthetic process (GO:0046189)3.75001135
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73791887
444-hydroxyproline metabolic process (GO:0019471)3.68952023
45positive regulation of histone deacetylation (GO:0031065)3.68037702
46negative regulation of histone methylation (GO:0031061)3.66580802
47nuclear pore organization (GO:0006999)3.66504486
48regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.66471090
49positive regulation of defense response to virus by host (GO:0002230)3.65933424
50tryptophan metabolic process (GO:0006568)3.61409241
51arginine catabolic process (GO:0006527)3.58414566
52cell migration in hindbrain (GO:0021535)3.57398745
53negative regulation of fatty acid transport (GO:2000192)3.53546019
54protein hydroxylation (GO:0018126)3.49926913
55indolalkylamine metabolic process (GO:0006586)3.49543747
56peptidyl-lysine dimethylation (GO:0018027)3.49120254
57water-soluble vitamin biosynthetic process (GO:0042364)3.43780339
58neural crest cell migration (GO:0001755)3.43722654
59cellular biogenic amine catabolic process (GO:0042402)3.38860043
60amine catabolic process (GO:0009310)3.38860043
61secondary metabolic process (GO:0019748)3.37240456
62regulation of fever generation (GO:0031620)3.34164294
63regulation of heat generation (GO:0031650)3.33346362
64ganglion development (GO:0061548)3.32839721
65negative regulation of systemic arterial blood pressure (GO:0003085)3.32237510
66peptidyl-proline hydroxylation (GO:0019511)3.31376348
67regulation of striated muscle cell apoptotic process (GO:0010662)3.29222044
68positive regulation of prostaglandin secretion (GO:0032308)3.26755265
69regulation of vitamin metabolic process (GO:0030656)3.24490701
70negative regulation of calcium ion transport into cytosol (GO:0010523)3.23560750
71mitotic cell cycle arrest (GO:0071850)3.20961041
72endoderm formation (GO:0001706)3.14041649
73mesenchymal cell proliferation (GO:0010463)3.13139636
74negative regulation of telomere maintenance (GO:0032205)3.10889562
75histone H3-K9 demethylation (GO:0033169)3.09338948
76positive regulation of chemokine biosynthetic process (GO:0045080)3.05938616
77cellular response to nicotine (GO:0071316)3.04865481
78sulfation (GO:0051923)3.02758595
79apoptotic process involved in development (GO:1902742)2.98782912
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97732407
81somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97732407
82isotype switching (GO:0045190)2.97732407
83adult heart development (GO:0007512)2.96778178
84positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.96697366
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96319474
86semaphorin-plexin signaling pathway (GO:0071526)2.96022668
87regulation of immunoglobulin secretion (GO:0051023)2.94462259
88regulation of heart morphogenesis (GO:2000826)2.93223867
89regulation of translational fidelity (GO:0006450)2.93158667
90maturation of 5.8S rRNA (GO:0000460)2.90881694
91platelet dense granule organization (GO:0060155)2.88443575
92cellular response to exogenous dsRNA (GO:0071360)2.88198029
93magnesium ion transport (GO:0015693)2.86870777
94positive regulation of glomerulus development (GO:0090193)2.86053788
95nerve growth factor signaling pathway (GO:0038180)2.85347389
96positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.85339687
97pore complex assembly (GO:0046931)2.84263760
98negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.84195366
99dosage compensation (GO:0007549)2.83850593
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83747808
101regulation of interferon-alpha production (GO:0032647)2.83071144
102positive regulation of guanylate cyclase activity (GO:0031284)2.82932879
103negative regulation of lipid storage (GO:0010888)2.82150677
104regulation of defense response to virus by host (GO:0050691)2.81295908
105regulation of B cell apoptotic process (GO:0002902)2.81027563
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80524400
107regulation of endothelial cell chemotaxis (GO:2001026)2.79946185
108negative regulation of neurotransmitter transport (GO:0051589)2.79851918
109regulation of neuroblast proliferation (GO:1902692)2.78401234
110dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77784765
111myoblast fusion (GO:0007520)2.77549003
112regulation of cell proliferation involved in kidney development (GO:1901722)2.74205465
113positive regulation of T-helper 1 type immune response (GO:0002827)2.73322455
114positive regulation of cAMP-mediated signaling (GO:0043950)2.73156955
115folic acid-containing compound biosynthetic process (GO:0009396)2.73135357
116regulation of prostaglandin secretion (GO:0032306)2.72283761
117melanocyte differentiation (GO:0030318)2.72205588
118kidney morphogenesis (GO:0060993)2.70456074
119cytoplasmic mRNA processing body assembly (GO:0033962)2.69389664
120syncytium formation by plasma membrane fusion (GO:0000768)2.68531440
121regulation of hippo signaling (GO:0035330)2.68123185
122positive regulation of lymphocyte apoptotic process (GO:0070230)2.67683866
123regulation of cholesterol homeostasis (GO:2000188)2.66710935
124response to ATP (GO:0033198)2.66493883
125heart morphogenesis (GO:0003007)2.65271392
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.65039150
127protein K6-linked ubiquitination (GO:0085020)2.63661222
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63309705
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.63309705
130NADH dehydrogenase complex assembly (GO:0010257)2.63309705
131protein K11-linked deubiquitination (GO:0035871)2.63259435
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62709102
133regulation of mesoderm development (GO:2000380)2.62314220
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.62297526
135regulation of histone H3-K9 methylation (GO:0051570)2.62276859
136regulation of action potential (GO:0098900)2.61795717
137body morphogenesis (GO:0010171)2.61188761
138regulation of gene silencing by RNA (GO:0060966)2.60757940
139regulation of posttranscriptional gene silencing (GO:0060147)2.60757940
140regulation of gene silencing by miRNA (GO:0060964)2.60757940
141preassembly of GPI anchor in ER membrane (GO:0016254)2.59200675
142modulation of growth of symbiont involved in interaction with host (GO:0044144)2.59091691
143regulation of growth of symbiont in host (GO:0044126)2.59091691
144negative regulation of growth of symbiont in host (GO:0044130)2.59091691
145negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.59091691
146developmental programmed cell death (GO:0010623)2.57769621
147mannosylation (GO:0097502)2.57564590
148regulation of guanylate cyclase activity (GO:0031282)2.56478220
149indole-containing compound metabolic process (GO:0042430)2.55717236
150regulation of chemokine biosynthetic process (GO:0045073)2.55342658
151negative regulation of membrane potential (GO:0045837)2.54638466
152nodal signaling pathway (GO:0038092)2.54533272
153negative regulation by host of viral transcription (GO:0043922)2.53970314
154histone demethylation (GO:0016577)2.52920916
155histone H2A monoubiquitination (GO:0035518)2.52662586
156response to lipoprotein particle (GO:0055094)2.52501813
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51781463
158trophectodermal cell differentiation (GO:0001829)2.50629906
159rRNA catabolic process (GO:0016075)2.50586147
160detection of light stimulus involved in visual perception (GO:0050908)2.50250390
161detection of light stimulus involved in sensory perception (GO:0050962)2.50250390
162pseudouridine synthesis (GO:0001522)2.48493305
163regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48462366
164positive regulation of fatty acid transport (GO:2000193)2.48152764
165response to UV-C (GO:0010225)2.48128254
166positive regulation of interleukin-12 production (GO:0032735)2.47634451
167protein polyglutamylation (GO:0018095)2.47549453
168labyrinthine layer development (GO:0060711)2.46808215
169negative regulation of stem cell proliferation (GO:2000647)2.46763443
170response to dietary excess (GO:0002021)2.46115405
171negative regulation of interleukin-12 production (GO:0032695)2.45749098
172regulation of memory T cell differentiation (GO:0043380)2.45620443
173regulation of mitotic spindle checkpoint (GO:1903504)2.45039259
174regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45039259
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.45039235
176mitotic G1 DNA damage checkpoint (GO:0031571)2.44723085
177respiratory chain complex IV assembly (GO:0008535)2.41593233
178NLS-bearing protein import into nucleus (GO:0006607)2.40764171
179syncytium formation (GO:0006949)2.39810780
180negative regulation of monooxygenase activity (GO:0032769)2.38753116
181positive regulation of cell cycle G2/M phase transition (GO:1902751)2.38230567
182positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.38230567
183negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.38106815
184mitotic G1/S transition checkpoint (GO:0044819)2.37813380
185NAD biosynthetic process (GO:0009435)2.36882783
186histone lysine demethylation (GO:0070076)2.35939096
187cell adhesion mediated by integrin (GO:0033627)2.35930555
188mitotic sister chromatid cohesion (GO:0007064)2.35494050
189protein demethylation (GO:0006482)2.34867624
190protein dealkylation (GO:0008214)2.34867624
191regulation of RNA export from nucleus (GO:0046831)2.31415860
192regulation of transforming growth factor beta2 production (GO:0032909)2.30541326
193NIK/NF-kappaB signaling (GO:0038061)2.28871959
194establishment of nucleus localization (GO:0040023)2.28714727
195pigment biosynthetic process (GO:0046148)2.28454493
196endothelial cell morphogenesis (GO:0001886)2.28256051
197protein localization to kinetochore (GO:0034501)2.27428701
198melanin biosynthetic process (GO:0042438)12.4305823
199melanin metabolic process (GO:0006582)11.3248286
200secondary metabolite biosynthetic process (GO:0044550)10.1094004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.34850076
2NOTCH1_21737748_ChIP-Seq_TLL_Human4.93949249
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.61979048
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.48045778
5ZNF274_21170338_ChIP-Seq_K562_Hela4.37192831
6E2F7_22180533_ChIP-Seq_HELA_Human3.95568283
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.84666994
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.67798496
9VDR_22108803_ChIP-Seq_LS180_Human3.25100939
10MYC_22102868_ChIP-Seq_BL_Human3.16916677
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83892788
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.82605973
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73213042
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72539794
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.63784604
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.60064918
17KDM2B_26808549_Chip-Seq_DND41_Human2.47601765
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42763984
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.39080368
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33845669
21EWS_26573619_Chip-Seq_HEK293_Human2.29267525
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28097029
23TCF7_22412390_ChIP-Seq_EML_Mouse2.26845791
24IRF1_19129219_ChIP-ChIP_H3396_Human2.24496289
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23221189
26VDR_21846776_ChIP-Seq_THP-1_Human2.23101532
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22228433
28MYC_18940864_ChIP-ChIP_HL60_Human2.20161717
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16120398
30IGF1R_20145208_ChIP-Seq_DFB_Human2.12518324
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11825854
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.00888260
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.99582852
34ELK1_19687146_ChIP-ChIP_HELA_Human1.99185862
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98999443
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98127518
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98011551
38FUS_26573619_Chip-Seq_HEK293_Human1.95539168
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.89526514
40GBX2_23144817_ChIP-Seq_PC3_Human1.89519655
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85494521
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.84568083
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82157030
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79858193
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.78595645
46KDM2B_26808549_Chip-Seq_K562_Human1.78359725
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77811556
48VDR_23849224_ChIP-Seq_CD4+_Human1.77220696
49P300_19829295_ChIP-Seq_ESCs_Human1.72091589
50CLOCK_20551151_ChIP-Seq_293T_Human1.72009458
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71721698
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66794422
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64410330
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60916474
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59861299
56ER_23166858_ChIP-Seq_MCF-7_Human1.58406246
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.56942414
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56410884
59VDR_24763502_ChIP-Seq_THP-1_Human1.56032186
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51779623
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.50969707
62UTX_26944678_Chip-Seq_JUKART_Human1.50824715
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50309571
64ATF3_27146783_Chip-Seq_COLON_Human1.47704635
65MAF_26560356_Chip-Seq_TH1_Human1.47180526
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45400962
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45341327
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.44869005
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44313754
70TP53_22573176_ChIP-Seq_HFKS_Human1.43378673
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42705934
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42428391
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42260808
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42206964
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42033983
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.40611192
77RACK7_27058665_Chip-Seq_MCF-7_Human1.40586158
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.39630490
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38885120
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38141266
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.36192939
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32938310
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32710890
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31365310
85NANOG_19829295_ChIP-Seq_ESCs_Human1.31100270
86SOX2_19829295_ChIP-Seq_ESCs_Human1.31100270
87ZNF263_19887448_ChIP-Seq_K562_Human1.31053178
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30106638
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29459332
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.29459332
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29361499
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29320447
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28993205
94CBP_20019798_ChIP-Seq_JUKART_Human1.28571288
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28571288
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28207190
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28081642
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27340644
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27242724
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27147107
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24797458
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24743383
103CDX2_22108803_ChIP-Seq_LS180_Human1.22799422
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22353568
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20965165
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20718536
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20292886
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20088616
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20088616
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20088616
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19584466
112TFEB_21752829_ChIP-Seq_HELA_Human1.19572212
113GATA3_26560356_Chip-Seq_TH2_Human1.19276328
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.18699323
115MYB_26560356_Chip-Seq_TH1_Human1.18319051
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18128214
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17952794
118SPI1_23127762_ChIP-Seq_K562_Human1.17871836
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17704855
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17511188
121GATA6_25053715_ChIP-Seq_YYC3_Human1.17177430
122NCOR1_26117541_ChIP-Seq_K562_Human1.16726807
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16478780
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16433758
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.15550523
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.15432648
127TP53_16413492_ChIP-PET_HCT116_Human1.15311185
128FOXP3_21729870_ChIP-Seq_TREG_Human1.15053967
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.14280301
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13933229
131ISL1_27105846_Chip-Seq_CPCs_Mouse1.13206900
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11749797
133BCAT_22108803_ChIP-Seq_LS180_Human1.11704031
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11367829
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10361156
136RUNX_20019798_ChIP-Seq_JUKART_Human1.09948784
137GATA3_21878914_ChIP-Seq_MCF-7_Human1.09765263
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.09553910
139CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09329561
140DROSHA_22980978_ChIP-Seq_HELA_Human1.09141685
141PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08370189
142NFE2_27457419_Chip-Seq_LIVER_Mouse1.07539672
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07259147
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05660110
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05592081
146ESR1_21235772_ChIP-Seq_MCF-7_Human1.04303648
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03936868
148TAF15_26573619_Chip-Seq_HEK293_Human1.03894334
149KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03875186
150SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03861798
151EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03690806
152STAT3_23295773_ChIP-Seq_U87_Human1.03286960
153NCOR_22424771_ChIP-Seq_293T_Human1.03098235
154HOXB7_26014856_ChIP-Seq_BT474_Human1.03065240
155CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02919612
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02542463
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02542463
158TCF4_23295773_ChIP-Seq_U87_Human1.01974516
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01942656
160PRDM14_20953172_ChIP-Seq_ESCs_Human1.01554029
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01154982
162MYB_26560356_Chip-Seq_TH2_Human1.01063914
163AR_21909140_ChIP-Seq_LNCAP_Human1.00830108
164BRD4_25478319_ChIP-Seq_HGPS_Human1.00492446
165E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00112541
166AR_25329375_ChIP-Seq_VCAP_Human0.99059849
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98972855
168CREB1_26743006_Chip-Seq_LNCaP_Human0.98808649
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.98514090
170CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98290878
171FLI1_21867929_ChIP-Seq_TH2_Mouse0.98182829
172JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98048169
173E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97369584
174CHD1_26751641_Chip-Seq_LNCaP_Human0.97369436
175GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96890992
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96597718
177POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96597718
178RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96256132
179SCL_19346495_ChIP-Seq_HPC-7_Human0.95556039
180SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94811615
181PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94575481
182SMAD4_21799915_ChIP-Seq_A2780_Human0.94189120
183MITF_21258399_ChIP-Seq_MELANOMA_Human0.93922187
184CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93257293
185TP53_18474530_ChIP-ChIP_U2OS_Human0.93202169
186AR_20517297_ChIP-Seq_VCAP_Human0.92538991
187PIAS1_25552417_ChIP-Seq_VCAP_Human0.91991065
188MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91464605
189SMAD_19615063_ChIP-ChIP_OVARY_Human0.90810189
190IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90236893
191GATA1_19941826_ChIP-Seq_K562_Human0.90109015
192TBX20_22080862_ChIP-Seq_HEART_Mouse0.89723589
193TBX20_22328084_ChIP-Seq_HEART_Mouse0.89723589
194VDR_24787735_ChIP-Seq_THP-1_Human0.88462661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.67629163
2MP0005171_absent_coat_pigmentation5.52681322
3MP0002877_abnormal_melanocyte_morpholog4.55031592
4MP0003195_calcinosis4.49928747
5MP0000569_abnormal_digit_pigmentation4.21447305
6MP0005408_hypopigmentation3.83368245
7MP0003567_abnormal_fetal_cardiomyocyte3.20992792
8MP0000371_diluted_coat_color3.09823263
9MP0002837_dystrophic_cardiac_calcinosis3.01505880
10MP0003950_abnormal_plasma_membrane2.68045377
11MP0002254_reproductive_system_inflammat2.55886512
12MP0004381_abnormal_hair_follicle2.53812594
13MP0002148_abnormal_hypersensitivity_rea2.51864762
14MP0009764_decreased_sensitivity_to2.47141358
15MP0002653_abnormal_ependyma_morphology2.47112112
16MP0000015_abnormal_ear_pigmentation2.41725526
17MP0009785_altered_susceptibility_to2.39672211
18MP0003724_increased_susceptibility_to2.27157508
19MP0000516_abnormal_urinary_system2.19194240
20MP0005367_renal/urinary_system_phenotyp2.19194240
21MP0002332_abnormal_exercise_endurance2.19108453
22MP0003303_peritoneal_inflammation2.16907180
23MP0003705_abnormal_hypodermis_morpholog2.15829697
24MP0002095_abnormal_skin_pigmentation2.14032980
25MP0005377_hearing/vestibular/ear_phenot2.10924032
26MP0003878_abnormal_ear_physiology2.10924032
27MP0002638_abnormal_pupillary_reflex2.08186960
28MP0003045_fibrosis2.07512897
29MP0003136_yellow_coat_color2.05645599
30MP0005257_abnormal_intraocular_pressure2.04496038
31MP0003787_abnormal_imprinting2.04431718
32MP0004233_abnormal_muscle_weight2.03969650
33MP0010307_abnormal_tumor_latency1.99275007
34MP0005646_abnormal_pituitary_gland1.98411352
35MP0002138_abnormal_hepatobiliary_system1.91709229
36MP0003718_maternal_effect1.86685683
37MP0002075_abnormal_coat/hair_pigmentati1.84115445
38MP0002876_abnormal_thyroid_physiology1.83375266
39MP0006292_abnormal_olfactory_placode1.82024595
40MP0005076_abnormal_cell_differentiation1.80603157
41MP0002163_abnormal_gland_morphology1.79604088
42MP0003646_muscle_fatigue1.77897756
43MP0004858_abnormal_nervous_system1.77638623
44MP0002751_abnormal_autonomic_nervous1.76448288
45MP0005174_abnormal_tail_pigmentation1.76234717
46MP0008875_abnormal_xenobiotic_pharmacok1.72234898
47MP0001501_abnormal_sleep_pattern1.72147305
48MP0005197_abnormal_uvea_morphology1.69647756
49MP0003123_paternal_imprinting1.67747886
50MP0001324_abnormal_eye_pigmentation1.65950500
51MP0003693_abnormal_embryo_hatching1.60495427
52MP0008961_abnormal_basal_metabolism1.58932043
53MP0008058_abnormal_DNA_repair1.55542349
54MP0010234_abnormal_vibrissa_follicle1.54637626
55MP0008872_abnormal_physiological_respon1.53251515
56MP0009046_muscle_twitch1.50424301
57MP0004133_heterotaxia1.49080215
58MP0001968_abnormal_touch/_nociception1.46313543
59MP0001186_pigmentation_phenotype1.45528075
60MP0005389_reproductive_system_phenotype1.43471502
61MP0003300_gastrointestinal_ulcer1.42744379
62MP0006138_congestive_heart_failure1.41969206
63MP0003566_abnormal_cell_adhesion1.39361400
64MP0004885_abnormal_endolymph1.37207700
65MP0005248_abnormal_Harderian_gland1.36157838
66MP0004084_abnormal_cardiac_muscle1.35813693
67MP0003890_abnormal_embryonic-extraembry1.33719820
68MP0005000_abnormal_immune_tolerance1.32082961
69MP0005379_endocrine/exocrine_gland_phen1.30109816
70MP0005551_abnormal_eye_electrophysiolog1.28704812
71MP0001485_abnormal_pinna_reflex1.27320858
72MP0005671_abnormal_response_to1.26541600
73MP0001919_abnormal_reproductive_system1.24541902
74MP0005387_immune_system_phenotype1.23573289
75MP0001790_abnormal_immune_system1.23573289
76MP0000733_abnormal_muscle_development1.22121929
77MP0010352_gastrointestinal_tract_polyps1.21972344
78MP0008877_abnormal_DNA_methylation1.21423918
79MP0003122_maternal_imprinting1.21205981
80MP0002160_abnormal_reproductive_system1.20954845
81MP0005266_abnormal_metabolism1.18054998
82MP0004264_abnormal_extraembryonic_tissu1.17008643
83MP0001835_abnormal_antigen_presentation1.15717490
84MP0002693_abnormal_pancreas_physiology1.15415498
85MP0005645_abnormal_hypothalamus_physiol1.15157769
86MP0006082_CNS_inflammation1.14585032
87MP0009765_abnormal_xenobiotic_induced1.14453718
88MP0000427_abnormal_hair_cycle1.13647842
89MP0002139_abnormal_hepatobiliary_system1.12927259
90MP0003121_genomic_imprinting1.12862530
91MP0005075_abnormal_melanosome_morpholog1.12462812
92MP0000685_abnormal_immune_system1.10256939
93MP0005084_abnormal_gallbladder_morpholo1.09819920
94MP0003119_abnormal_digestive_system1.07536864
95MP0010094_abnormal_chromosome_stability1.07439950
96MP0002452_abnormal_antigen_presenting1.05494623
97MP0001853_heart_inflammation1.05431518
98MP0001800_abnormal_humoral_immune1.04679339
99MP0003011_delayed_dark_adaptation1.03453710
100MP0005623_abnormal_meninges_morphology1.01855294
101MP0003786_premature_aging1.01320335
102MP0004197_abnormal_fetal_growth/weight/1.01284981
103MP0001764_abnormal_homeostasis0.97209387
104MP0000003_abnormal_adipose_tissue0.96917449
105MP0002736_abnormal_nociception_after0.96010114
106MP0005167_abnormal_blood-brain_barrier0.95467257
107MP0008770_decreased_survivor_rate0.95105495
108MP0005647_abnormal_sex_gland0.95033219
109MP0003077_abnormal_cell_cycle0.95000639
110MP0005253_abnormal_eye_physiology0.94691602
111MP0002723_abnormal_immune_serum0.94001171
112MP0005310_abnormal_salivary_gland0.93670963
113MP0008007_abnormal_cellular_replicative0.92503034
114MP0003453_abnormal_keratinocyte_physiol0.92264347
115MP0004142_abnormal_muscle_tone0.91743553
116MP0000647_abnormal_sebaceous_gland0.91222212
117MP0001542_abnormal_bone_strength0.90612019
118MP0003091_abnormal_cell_migration0.89134844
119MP0002928_abnormal_bile_duct0.89013393
120MP0010678_abnormal_skin_adnexa0.88603885
121MP0000631_abnormal_neuroendocrine_gland0.88330729
122MP0003111_abnormal_nucleus_morphology0.87577854
123MP0003186_abnormal_redox_activity0.86525844
124MP0002127_abnormal_cardiovascular_syste0.86147655
125MP0003937_abnormal_limbs/digits/tail_de0.84877569
126MP0000537_abnormal_urethra_morphology0.83921006
127MP0001849_ear_inflammation0.82451898
128MP0001845_abnormal_inflammatory_respons0.80565243
129MP0004130_abnormal_muscle_cell0.80342300
130MP0002102_abnormal_ear_morphology0.80175273
131MP0003868_abnormal_feces_composition0.79461137
132MP0005023_abnormal_wound_healing0.79317763
133MP0005332_abnormal_amino_acid0.79225155
134MP0000230_abnormal_systemic_arterial0.78714506
135MP0001873_stomach_inflammation0.78683950
136MP0004947_skin_inflammation0.77890980
137MP0005410_abnormal_fertilization0.77027167
138MP0008469_abnormal_protein_level0.76489502
139MP0002282_abnormal_trachea_morphology0.76145164
140MP0002092_abnormal_eye_morphology0.73975717
141MP0002166_altered_tumor_susceptibility0.73904088
142MP0006054_spinal_hemorrhage0.73433082
143MP0000470_abnormal_stomach_morphology0.73211335
144MP0001293_anophthalmia0.72949959
145MP0004808_abnormal_hematopoietic_stem0.72698836
146MP0002419_abnormal_innate_immunity0.72473887
147MP0001119_abnormal_female_reproductive0.70088750
148MP0001270_distended_abdomen0.69927721
149MP0000534_abnormal_ureter_morphology0.68997633
150MP0001986_abnormal_taste_sensitivity0.68856063
151MP0009840_abnormal_foam_cell0.68615624
152MP0002084_abnormal_developmental_patter0.68419339
153MP0000383_abnormal_hair_follicle0.68350396
154MP0001730_embryonic_growth_arrest0.67898912
155MP0003984_embryonic_growth_retardation0.67551910
156MP0005195_abnormal_posterior_eye0.67222717
157MP0002086_abnormal_extraembryonic_tissu0.66951930
158MP0008775_abnormal_heart_ventricle0.66701209
159MP0005380_embryogenesis_phenotype0.66271909
160MP0001672_abnormal_embryogenesis/_devel0.66271909
161MP0003172_abnormal_lysosome_physiology0.65314086
162MP0002088_abnormal_embryonic_growth/wei0.64231866
163MP0010630_abnormal_cardiac_muscle0.63983219
164MP0005058_abnormal_lysosome_morphology0.63558031
165MP0002090_abnormal_vision0.62841863
166MP0000350_abnormal_cell_proliferation0.59695890
167MP0009703_decreased_birth_body0.59527108
168MP0005083_abnormal_biliary_tract0.58920074
169MP0000703_abnormal_thymus_morphology0.58065206
170MP0000538_abnormal_urinary_bladder0.58025192
171MP0000367_abnormal_coat/_hair0.57586797
172MP0000762_abnormal_tongue_morphology0.57430230
173MP0001299_abnormal_eye_distance/0.56222071
174MP0004043_abnormal_pH_regulation0.55811819
175MP0002080_prenatal_lethality0.55748264
176MP0002938_white_spotting0.55580371
177MP0003115_abnormal_respiratory_system0.54456423
178MP0001697_abnormal_embryo_size0.54311812
179MP0005375_adipose_tissue_phenotype0.53499808
180MP0002909_abnormal_adrenal_gland0.53439025
181MP0006072_abnormal_retinal_apoptosis0.49847421

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)5.40134898
2Aplasia/Hypoplasia affecting the retina (HP:0008061)5.10717223
3Blue irides (HP:0000635)4.96507226
4Ocular albinism (HP:0001107)4.53463503
5Overlapping toe (HP:0001845)4.23898301
6Hypoplasia of the fovea (HP:0007750)3.96484751
7Aplasia/Hypoplasia of the fovea (HP:0008060)3.96484751
8Hypopigmentation of the fundus (HP:0007894)3.85932038
9Subacute progressive viral hepatitis (HP:0006572)3.84753491
10Congenital stationary night blindness (HP:0007642)3.84440623
11Iris hypopigmentation (HP:0007730)3.72014339
12Enlarged penis (HP:0000040)3.61502685
13Hyperacusis (HP:0010780)3.58623430
14Macroorchidism (HP:0000053)3.57115703
15Hypercortisolism (HP:0001578)3.56141824
16Pancreatic cysts (HP:0001737)3.55022732
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.49926557
18Stomatitis (HP:0010280)3.40114964
19Cutaneous melanoma (HP:0012056)3.26710376
20Pendular nystagmus (HP:0012043)3.20906620
21Abnormality of alanine metabolism (HP:0010916)3.17243378
22Hyperalaninemia (HP:0003348)3.17243378
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17243378
24Abnormality of the fovea (HP:0000493)3.13641687
25Pheochromocytoma (HP:0002666)3.11208372
26Pancreatic fibrosis (HP:0100732)3.10335204
27Spastic diplegia (HP:0001264)3.07821677
28Generalized hypopigmentation (HP:0007513)3.01588053
29Abnormality of the parathyroid morphology (HP:0011766)2.96545322
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.95183299
31Facial shape deformation (HP:0011334)2.93024288
32Potter facies (HP:0002009)2.93024288
33Bowel diverticulosis (HP:0005222)2.92576732
34Freckling (HP:0001480)2.82779789
35Abnormality of midbrain morphology (HP:0002418)2.75923655
36Molar tooth sign on MRI (HP:0002419)2.75923655
37Abnormality of the pons (HP:0007361)2.75173824
38True hermaphroditism (HP:0010459)2.71932971
39Abolished electroretinogram (ERG) (HP:0000550)2.71140584
40Upper limb amyotrophy (HP:0009129)2.63231561
41Distal upper limb amyotrophy (HP:0007149)2.63231561
42Elfin facies (HP:0004428)2.61943839
43Hand muscle atrophy (HP:0009130)2.59826916
44Tubular atrophy (HP:0000092)2.58489560
45Type II lissencephaly (HP:0007260)2.58083400
46Hypoplasia of the pons (HP:0012110)2.56995736
47Optic neuritis (HP:0100653)2.55884182
48Retrobulbar optic neuritis (HP:0100654)2.55884182
49Abnormality of the renal cortex (HP:0011035)2.54030197
50Nephronophthisis (HP:0000090)2.51805287
51Bilateral sensorineural hearing impairment (HP:0008619)2.48654922
52Hyperparathyroidism (HP:0000843)2.44159600
53Hypoventilation (HP:0002791)2.43783393
54Abnormality of the renal collecting system (HP:0004742)2.43580089
55Attenuation of retinal blood vessels (HP:0007843)2.43523509
56Absent thumb (HP:0009777)2.41314234
57Fused cervical vertebrae (HP:0002949)2.38774725
58Short 1st metacarpal (HP:0010034)2.36663566
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.36663566
60Severe muscular hypotonia (HP:0006829)2.36615577
61Abnormal rod and cone electroretinograms (HP:0008323)2.36100988
62Furrowed tongue (HP:0000221)2.35913278
63Stenosis of the external auditory canal (HP:0000402)2.35573872
64Neuroendocrine neoplasm (HP:0100634)2.34736654
65Increased nuchal translucency (HP:0010880)2.33804805
66Failure to thrive in infancy (HP:0001531)2.33059092
67Overriding aorta (HP:0002623)2.32568334
68Methylmalonic acidemia (HP:0002912)2.29573486
69Cerebral aneurysm (HP:0004944)2.26128093
70Hypoplasia of the iris (HP:0007676)2.24970151
71Chronic hepatic failure (HP:0100626)2.24297286
72Carpal bone hypoplasia (HP:0001498)2.24176185
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23429098
74Micronodular cirrhosis (HP:0001413)2.22995703
75Disproportionate tall stature (HP:0001519)2.22654462
76Large for gestational age (HP:0001520)2.22105353
77Renovascular hypertension (HP:0100817)2.21139123
78Congenital sensorineural hearing impairment (HP:0008527)2.20929054
79Chorioretinal atrophy (HP:0000533)2.20457919
80Duplicated collecting system (HP:0000081)2.20333349
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18982018
82Genetic anticipation (HP:0003743)2.18980945
83Methylmalonic aciduria (HP:0012120)2.18755967
84Renal cortical cysts (HP:0000803)2.17675287
85Gaze-evoked nystagmus (HP:0000640)2.16613245
86Parakeratosis (HP:0001036)2.16050647
87Insomnia (HP:0100785)2.15718724
88Progressive inability to walk (HP:0002505)2.15559630
89Thyroid carcinoma (HP:0002890)2.13505907
90Inability to walk (HP:0002540)2.13421971
91Abnormality of B cell number (HP:0010975)2.12597669
92Congenital, generalized hypertrichosis (HP:0004540)2.12182489
933-Methylglutaconic aciduria (HP:0003535)2.11945231
94Abnormality of the renal medulla (HP:0100957)2.08730878
95Aplasia/Hypoplasia of the uvula (HP:0010293)2.07647683
96Hyperthyroidism (HP:0000836)2.06856418
97Polydipsia (HP:0001959)2.05332516
98Abnormal drinking behavior (HP:0030082)2.05332516
99Viral hepatitis (HP:0006562)2.03221623
100Prostate neoplasm (HP:0100787)2.03153187
101Heterotopia (HP:0002282)2.03148893
102Ulnar deviation of finger (HP:0009465)2.01494043
103Menstrual irregularities (HP:0000858)2.01189215
104Short hallux (HP:0010109)1.99215587
105Keratoconus (HP:0000563)1.99213178
106Increased corneal curvature (HP:0100692)1.99213178
107Scapular winging (HP:0003691)1.98863333
108Clumsiness (HP:0002312)1.98536445
109Stomach cancer (HP:0012126)1.98467324
110Truncal obesity (HP:0001956)1.96939393
111Bicornuate uterus (HP:0000813)1.96400225
112Abnormality of the nasal septum (HP:0000419)1.95671393
113Abnormality of the 1st metacarpal (HP:0010009)1.95085226
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.94984217
115Abnormality of DNA repair (HP:0003254)1.94628313
116Hematochezia (HP:0002573)1.94365162
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93499522
118Ectopic kidney (HP:0000086)1.93402728
119White forelock (HP:0002211)1.93298721
120Vertebral arch anomaly (HP:0008438)1.93047409
121Cafe-au-lait spot (HP:0000957)1.92972056
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92833698
123Abnormality of the fingertips (HP:0001211)1.92439764
124IgG deficiency (HP:0004315)1.91521033
125Aplasia/hypoplasia of the uterus (HP:0008684)1.91329242
126Asplenia (HP:0001746)1.90408120
127Disproportionate short-trunk short stature (HP:0003521)1.90365377
128Amblyopia (HP:0000646)1.90088159
129Distal lower limb amyotrophy (HP:0008944)1.89656878
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.89153069
131Thick eyebrow (HP:0000574)1.88933998
132Erythroderma (HP:0001019)1.88557236
133Fair hair (HP:0002286)1.88265466
134Exotropia (HP:0000577)1.88118619
135Meningioma (HP:0002858)1.87846314
136Autoimmune thrombocytopenia (HP:0001973)1.87800008
137Sclerocornea (HP:0000647)1.85928963
138Pointed chin (HP:0000307)1.85686933
139Abnormality of vision evoked potentials (HP:0000649)1.85475812
140Neuroblastic tumors (HP:0004376)1.84831488
141Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.84831488
142Neuroblastoma (HP:0003006)1.84831488
143Primitive neuroectodermal tumor (HP:0030065)1.84831488
144Hyperventilation (HP:0002883)1.84827657
145B lymphocytopenia (HP:0010976)1.84035008
146Meckel diverticulum (HP:0002245)1.83273487
147Orchitis (HP:0100796)1.83026123
148Anencephaly (HP:0002323)1.82053033
149Increased CSF lactate (HP:0002490)1.81744405
150Bile duct proliferation (HP:0001408)1.81359576
151Abnormal biliary tract physiology (HP:0012439)1.81359576
152Chromsome breakage (HP:0040012)1.81066300
153Poor head control (HP:0002421)1.80727311
154Broad-based gait (HP:0002136)1.80543936
155Abnormality of the ileum (HP:0001549)1.80051338
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79888956
157Upper limb muscle weakness (HP:0003484)1.79581087
158Concave nail (HP:0001598)1.79305013
159Abnormality of chromosome stability (HP:0003220)1.79268111
160Increased serum lactate (HP:0002151)1.77971463
161Long palpebral fissure (HP:0000637)1.76062128
162Posterior subcapsular cataract (HP:0007787)1.75583014
163Birth length less than 3rd percentile (HP:0003561)1.75138959
164Somatic mutation (HP:0001428)1.74782077
165Intestinal polyposis (HP:0200008)1.74098658
166Hypoplasia of the uterus (HP:0000013)1.73945220
167Long toe (HP:0010511)1.72598967
168Keratoconjunctivitis (HP:0001096)1.72341480
169Clubbing of toes (HP:0100760)1.72014331
170Cerebellar dysplasia (HP:0007033)1.70508596
171Ectropion (HP:0000656)1.70487088
172Neoplasm of the peripheral nervous system (HP:0100007)1.69956659
173Heterochromia iridis (HP:0001100)1.68566490
174Striae distensae (HP:0001065)1.67631617
175Renal duplication (HP:0000075)1.67154367
176Abnormality of the antihelix (HP:0009738)1.66281166
177Neoplasm of the thyroid gland (HP:0100031)1.64942130
178Obsessive-compulsive behavior (HP:0000722)1.64917739
179Intestinal polyp (HP:0005266)1.64125894
180Deviation of the thumb (HP:0009603)1.63905853
181Nervous tissue neoplasm (HP:0030060)1.63760673
182Neuroectodermal neoplasm (HP:0030061)1.63760673
183Neuroepithelial neoplasm (HP:0030063)1.63760673
184Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63424702
185Precocious puberty (HP:0000826)1.63328189
186Flat cornea (HP:0007720)1.62918377
187Lower limb amyotrophy (HP:0007210)1.62093424
188Coarse hair (HP:0002208)1.61370967
189Volvulus (HP:0002580)1.60907144
190Proximal placement of thumb (HP:0009623)1.59224683
191Generalized hypopigmentation of hair (HP:0011358)1.56828107
192Testicular neoplasm (HP:0010788)1.56519315
193Cerebral hemorrhage (HP:0001342)1.55843189
194Underdeveloped nasal alae (HP:0000430)1.55810308
195Generalized hyperpigmentation (HP:0007440)1.55342894
196Persistence of primary teeth (HP:0006335)1.52999686
197Abnormality of the corticospinal tract (HP:0002492)1.51781260
198Shallow orbits (HP:0000586)1.51682103
199Albinism (HP:0001022)1.51307274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.82308870
2FRK4.75013138
3MET4.03548841
4EEF2K3.67922601
5PKN23.46852593
6ADRBK23.43702228
7ZAK3.05536221
8FLT32.66036267
9EIF2AK32.65772110
10TLK12.62548844
11GRK12.59428498
12TRIB32.45406844
13BRSK22.41455255
14PLK42.41095563
15MKNK22.38405796
16PTK22.38008823
17CDK122.34038748
18NUAK12.32761320
19BMX2.27298593
20MAP4K22.22845623
21MARK32.22520698
22BMPR1B2.19462078
23SIK12.12167795
24IRAK32.08891323
25IKBKB2.02215178
26RET2.00250490
27ERBB41.95633452
28ALK1.86549423
29PIM21.84007848
30GRK71.80457911
31PDGFRA1.74431354
32NEK21.72537258
33PTK61.71691004
34IRAK41.66549551
35PDGFRB1.61116736
36WNK31.53444352
37NTRK11.50380253
38SCYL21.50112749
39MST41.45341624
40LATS11.45164235
41TTN1.45124665
42TAOK31.43986235
43WNK41.43661791
44TRIM281.36927115
45NEK11.36139833
46CAMK1G1.34579854
47IRAK11.31831871
48MKNK11.29230539
49TXK1.29187492
50ACVR1B1.29167263
51CHUK1.27991670
52JAK31.27978458
53RIPK11.27816451
54VRK11.23035013
55ZAP701.22282471
56MAP3K91.18350772
57MAP3K141.15934404
58OXSR11.15074331
59INSRR1.13611027
60CAMK1D1.13111066
61BUB11.10644328
62IKBKE1.10606360
63MTOR1.08617412
64STK101.06540566
65RPS6KB21.02114604
66BRD40.99669952
67MAP3K100.98180546
68FGFR20.97551777
69ITK0.97489825
70ICK0.97127241
71PLK20.96764476
72PINK10.96675307
73PLK30.95943180
74CSNK1G30.94852134
75STK390.94681644
76EIF2AK20.94641639
77TEC0.93390170
78FGFR10.91568014
79CSNK1G20.90084132
80BMPR20.88107280
81MAP2K30.87822314
82FGFR40.87297988
83CDK60.86977444
84CSNK1G10.86747178
85LRRK20.86091145
86AKT30.84573243
87PRKCI0.84425188
88MAPKAPK50.84275706
89MAP4K10.83018145
90TAF10.82798231
91MAP3K130.82632102
92CAMK40.82154941
93DDR20.82043926
94CDC70.81172389
95SGK30.81105950
96CHEK20.80132416
97MAP2K60.79906307
98WEE10.77007656
99RPS6KA50.76829938
100TIE10.76152798
101EPHA30.73083423
102TYRO30.72894486
103PLK10.72511715
104FGFR30.72175987
105ADRBK10.70904512
106MAP3K80.70867750
107ABL20.69743293
108MAP3K40.69695903
109ERBB30.67635052
110PDK20.66877994
111CSNK1A1L0.65871133
112DYRK30.65444156
113STK240.65009487
114RPS6KC10.64752145
115RPS6KL10.64752145
116NME10.64439571
117MATK0.62471220
118GSK3A0.62111510
119CDK80.60932582
120JAK10.60077511
121TNIK0.59734753
122MARK20.59453393
123PKN10.58693473
124PRKG20.58327985
125EPHB10.58026492
126PRKCE0.57230165
127CAMK10.56597630
128PNCK0.55721510
129KSR20.55719124
130INSR0.55030107
131STK160.53982127
132HCK0.53722811
133CASK0.53372908
134TSSK60.52971062
135TBK10.52431704
136DAPK20.52274111
137RPS6KA60.51966878
138PASK0.51463311
139CDK90.51013762
140LCK0.49919577
141ERBB20.49435812
142BCKDK0.48622960
143CDK40.48345901
144MAP3K70.47129386
145TGFBR10.47106522
146STK30.46927547
147IGF1R0.46839576
148OBSCN0.46331274
149SRPK10.45951944
150MAPK100.44876403
151PHKG20.44230033
152PHKG10.44230033
153SGK20.43243043
154IRAK20.42872255
155MOS0.42683965
156CAMKK10.42589146
157MELK0.42461422
158FER0.42431057
159MAPK150.41430681
160STK38L0.41345273
161PAK30.40998230
162MAPK80.40522255
163SIK20.39896599
164PAK20.39824803
165EPHA20.39442391
166AKT20.39412684
167WNK10.38894091
168HIPK20.38672250
169RPS6KA20.38156948
170CSNK1A10.38070952
171MAP2K70.37981662
172AKT10.37155615
173TRPM70.37095325
174CDC42BPA0.36773324
175MUSK0.36598245
176CHEK10.35816650
177PAK60.34507177
178PRKDC0.34376489
179ATM0.33730381
180STK40.32255729
181CDK20.32097227
182MAPK10.31954165
183CDK70.31191673
184PIM10.31086877
185PRKCH0.30648730

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.90493566
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.89162187
3Central carbon metabolism in cancer_Homo sapiens_hsa052302.72484598
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.59540058
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59262331
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.38262730
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32304739
8Sulfur metabolism_Homo sapiens_hsa009202.26906595
9Basal transcription factors_Homo sapiens_hsa030222.23024104
10Asthma_Homo sapiens_hsa053102.20710772
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19102756
12RNA polymerase_Homo sapiens_hsa030202.10591510
13mTOR signaling pathway_Homo sapiens_hsa041502.09351678
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01696535
15Chronic myeloid leukemia_Homo sapiens_hsa052201.98722732
16Arginine biosynthesis_Homo sapiens_hsa002201.96184880
17Phototransduction_Homo sapiens_hsa047441.90763452
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87868974
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82766622
20RNA degradation_Homo sapiens_hsa030181.78517864
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.77187204
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77086413
23Tryptophan metabolism_Homo sapiens_hsa003801.77082919
24Renal cell carcinoma_Homo sapiens_hsa052111.75593233
25MicroRNAs in cancer_Homo sapiens_hsa052061.72616473
26Homologous recombination_Homo sapiens_hsa034401.71863880
27Dorso-ventral axis formation_Homo sapiens_hsa043201.69920020
28Protein export_Homo sapiens_hsa030601.68951075
29Rheumatoid arthritis_Homo sapiens_hsa053231.67490999
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65613421
31Fanconi anemia pathway_Homo sapiens_hsa034601.63998445
32Non-small cell lung cancer_Homo sapiens_hsa052231.62911378
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62753794
34Lysine degradation_Homo sapiens_hsa003101.56889768
35p53 signaling pathway_Homo sapiens_hsa041151.56286041
36TNF signaling pathway_Homo sapiens_hsa046681.53090220
37Thyroid cancer_Homo sapiens_hsa052161.53084256
38Linoleic acid metabolism_Homo sapiens_hsa005911.52047869
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51667284
40Legionellosis_Homo sapiens_hsa051341.50740782
41Tyrosine metabolism_Homo sapiens_hsa003501.49833595
42Melanogenesis_Homo sapiens_hsa049161.48166036
43African trypanosomiasis_Homo sapiens_hsa051431.47284450
44Type II diabetes mellitus_Homo sapiens_hsa049301.46826769
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43677001
46Nitrogen metabolism_Homo sapiens_hsa009101.42548882
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.42246697
48Glioma_Homo sapiens_hsa052141.36969274
49T cell receptor signaling pathway_Homo sapiens_hsa046601.35243508
50Ether lipid metabolism_Homo sapiens_hsa005651.31568102
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31407323
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29872828
53Proteasome_Homo sapiens_hsa030501.29750903
54Estrogen signaling pathway_Homo sapiens_hsa049151.27916729
55Oxidative phosphorylation_Homo sapiens_hsa001901.27809373
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26305510
57Endometrial cancer_Homo sapiens_hsa052131.25985268
58Allograft rejection_Homo sapiens_hsa053301.25816234
59Adherens junction_Homo sapiens_hsa045201.21299496
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19813525
61Proteoglycans in cancer_Homo sapiens_hsa052051.19287781
62Pancreatic cancer_Homo sapiens_hsa052121.19087299
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17225196
64Graft-versus-host disease_Homo sapiens_hsa053321.12550356
65Type I diabetes mellitus_Homo sapiens_hsa049401.12090253
66Small cell lung cancer_Homo sapiens_hsa052221.12007276
67One carbon pool by folate_Homo sapiens_hsa006701.10736711
68B cell receptor signaling pathway_Homo sapiens_hsa046621.10356632
69Long-term depression_Homo sapiens_hsa047301.09254901
70Viral carcinogenesis_Homo sapiens_hsa052031.09182581
71Prolactin signaling pathway_Homo sapiens_hsa049171.08377979
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06448654
73Inositol phosphate metabolism_Homo sapiens_hsa005621.05850408
74HIF-1 signaling pathway_Homo sapiens_hsa040661.05476171
75Insulin resistance_Homo sapiens_hsa049311.05444963
76Caffeine metabolism_Homo sapiens_hsa002321.04987297
77Acute myeloid leukemia_Homo sapiens_hsa052211.04479856
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04161839
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03436367
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03090961
81VEGF signaling pathway_Homo sapiens_hsa043701.03047849
82Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02184930
83Prostate cancer_Homo sapiens_hsa052151.02057711
84AMPK signaling pathway_Homo sapiens_hsa041521.01822781
85ErbB signaling pathway_Homo sapiens_hsa040121.01724181
86Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01552717
87Phospholipase D signaling pathway_Homo sapiens_hsa040721.00448996
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00264575
89Insulin signaling pathway_Homo sapiens_hsa049100.98375816
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97600125
91FoxO signaling pathway_Homo sapiens_hsa040680.97502651
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96116344
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94387775
94Colorectal cancer_Homo sapiens_hsa052100.92457927
95Platelet activation_Homo sapiens_hsa046110.91510662
96Osteoclast differentiation_Homo sapiens_hsa043800.90084967
97Focal adhesion_Homo sapiens_hsa045100.89608400
98Galactose metabolism_Homo sapiens_hsa000520.88382217
99Melanoma_Homo sapiens_hsa052180.87740022
100Regulation of autophagy_Homo sapiens_hsa041400.87562781
101Rap1 signaling pathway_Homo sapiens_hsa040150.84875852
102Notch signaling pathway_Homo sapiens_hsa043300.83201579
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83157438
104RNA transport_Homo sapiens_hsa030130.82275721
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.82146396
106Malaria_Homo sapiens_hsa051440.81506104
107Sphingolipid metabolism_Homo sapiens_hsa006000.81455947
108Bladder cancer_Homo sapiens_hsa052190.80463992
109Butanoate metabolism_Homo sapiens_hsa006500.80308824
110Parkinsons disease_Homo sapiens_hsa050120.78348568
111HTLV-I infection_Homo sapiens_hsa051660.76666995
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76301496
113Steroid biosynthesis_Homo sapiens_hsa001000.75448377
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74394845
115Peroxisome_Homo sapiens_hsa041460.72628722
116Pyrimidine metabolism_Homo sapiens_hsa002400.71449622
117Hepatitis B_Homo sapiens_hsa051610.71273143
118GnRH signaling pathway_Homo sapiens_hsa049120.70853002
119Toxoplasmosis_Homo sapiens_hsa051450.70140430
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69800072
121Salivary secretion_Homo sapiens_hsa049700.69519482
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.69493045
123Systemic lupus erythematosus_Homo sapiens_hsa053220.69057403
124Glucagon signaling pathway_Homo sapiens_hsa049220.68779229
125Alcoholism_Homo sapiens_hsa050340.67256408
126mRNA surveillance pathway_Homo sapiens_hsa030150.66724614
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.66126760
128Pertussis_Homo sapiens_hsa051330.66073912
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65346811
130Biosynthesis of amino acids_Homo sapiens_hsa012300.64948984
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64926623
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64528805
133Pathways in cancer_Homo sapiens_hsa052000.63516394
134TGF-beta signaling pathway_Homo sapiens_hsa043500.63357325
135Herpes simplex infection_Homo sapiens_hsa051680.63014172
136Bile secretion_Homo sapiens_hsa049760.62901096
137Choline metabolism in cancer_Homo sapiens_hsa052310.62689734
138Autoimmune thyroid disease_Homo sapiens_hsa053200.62349291
139Influenza A_Homo sapiens_hsa051640.62115776
140MAPK signaling pathway_Homo sapiens_hsa040100.61261307
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61118838
142Endocytosis_Homo sapiens_hsa041440.60903113
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.60891489
144Chemokine signaling pathway_Homo sapiens_hsa040620.60632555
145Chemical carcinogenesis_Homo sapiens_hsa052040.60320741
146Purine metabolism_Homo sapiens_hsa002300.60201980
147Axon guidance_Homo sapiens_hsa043600.59973254
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59544986
149Hematopoietic cell lineage_Homo sapiens_hsa046400.58616948
150Hippo signaling pathway_Homo sapiens_hsa043900.57904753
151Fructose and mannose metabolism_Homo sapiens_hsa000510.56896495
152Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56655708
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56229896
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.55696238
155Ovarian steroidogenesis_Homo sapiens_hsa049130.55666671
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55421903
157Hepatitis C_Homo sapiens_hsa051600.55402245
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55114638
159Oocyte meiosis_Homo sapiens_hsa041140.54281419
160Thyroid hormone synthesis_Homo sapiens_hsa049180.54008905
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.53600693
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53562545
163Nicotine addiction_Homo sapiens_hsa050330.52854648
164Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52547961
165Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52386590
166Measles_Homo sapiens_hsa051620.51870262
167Apoptosis_Homo sapiens_hsa042100.51763290
168NF-kappa B signaling pathway_Homo sapiens_hsa040640.49595286
169Primary immunodeficiency_Homo sapiens_hsa053400.49043756
170Alzheimers disease_Homo sapiens_hsa050100.46575014
171Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44612304
172Taste transduction_Homo sapiens_hsa047420.43161694
173Huntingtons disease_Homo sapiens_hsa050160.42435522
174Collecting duct acid secretion_Homo sapiens_hsa049660.41408868
175Sulfur relay system_Homo sapiens_hsa041220.40550512
176Leishmaniasis_Homo sapiens_hsa051400.37915943
177Arachidonic acid metabolism_Homo sapiens_hsa005900.36699812
178Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35801984
179Epstein-Barr virus infection_Homo sapiens_hsa051690.35022499
180Non-homologous end-joining_Homo sapiens_hsa034500.34959244
181Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34869715
182Metabolic pathways_Homo sapiens_hsa011000.33901521
183ABC transporters_Homo sapiens_hsa020100.32585911
184Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32138745
185Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32015353
186Tuberculosis_Homo sapiens_hsa051520.31700315
187Mineral absorption_Homo sapiens_hsa049780.30069257
188Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29476372
189Primary bile acid biosynthesis_Homo sapiens_hsa001200.26900135

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