NOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83958198
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83958198
3antigen processing and presentation of endogenous antigen (GO:0019883)4.36454907
4negative regulation of cell killing (GO:0031342)4.14704437
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14704437
6positive regulation of gamma-delta T cell activation (GO:0046645)4.00295880
7immunoglobulin mediated immune response (GO:0016064)3.90957659
8positive regulation by symbiont of host defense response (GO:0052509)3.85421090
9modulation by symbiont of host defense response (GO:0052031)3.85421090
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85421090
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85421090
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.85421090
13modulation by symbiont of host immune response (GO:0052553)3.85421090
14germinal center formation (GO:0002467)3.79356675
15defense response to protozoan (GO:0042832)3.54586621
16negative regulation of erythrocyte differentiation (GO:0045647)3.47317241
17response to type I interferon (GO:0034340)3.46616826
18type I interferon signaling pathway (GO:0060337)3.39783754
19cellular response to type I interferon (GO:0071357)3.39783754
20response to protozoan (GO:0001562)3.37559251
21* detection of other organism (GO:0098543)3.20779513
22* regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18457690
23macrophage activation involved in immune response (GO:0002281)3.16739111
24positive regulation of type 2 immune response (GO:0002830)3.14875345
25positive regulation of interferon-alpha production (GO:0032727)3.11587825
26negative regulation of cytokine production involved in immune response (GO:0002719)3.09585547
27low-density lipoprotein particle clearance (GO:0034383)3.07429527
28myeloid dendritic cell differentiation (GO:0043011)3.03141218
29regulation of gamma-delta T cell activation (GO:0046643)3.03018307
30NIK/NF-kappaB signaling (GO:0038061)3.00158552
31mature B cell differentiation involved in immune response (GO:0002313)3.00076427
32* detection of bacterium (GO:0016045)2.99755014
33regulation of vitamin D biosynthetic process (GO:0060556)2.99442823
34regulation of gamma-delta T cell differentiation (GO:0045586)2.98496057
35negative regulation of innate immune response (GO:0045824)2.98013650
36* regulation of antigen processing and presentation (GO:0002577)2.96052862
37regulation of interferon-alpha production (GO:0032647)2.95036831
38regulation of T-helper 2 cell differentiation (GO:0045628)2.93415484
39regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91934424
40neutrophil activation involved in immune response (GO:0002283)2.91392767
41T cell migration (GO:0072678)2.90729174
42B cell mediated immunity (GO:0019724)2.90582176
43positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.89524603
44regulation of T cell tolerance induction (GO:0002664)2.87399081
45negative regulation of nitric oxide biosynthetic process (GO:0045019)2.86376047
46myeloid dendritic cell activation (GO:0001773)2.85449439
47negative regulation of T cell mediated immunity (GO:0002710)2.84154704
48regulation of interferon-beta biosynthetic process (GO:0045357)2.83795349
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81700380
50regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.80934193
51B cell receptor signaling pathway (GO:0050853)2.79124328
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75920008
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75821300
54regulation of type 2 immune response (GO:0002828)2.75249241
55sphingosine metabolic process (GO:0006670)2.74393856
56positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73144676
57positive regulation of interferon-beta production (GO:0032728)2.71953968
58positive regulation of B cell differentiation (GO:0045579)2.70608469
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69890949
60vascular endothelial growth factor signaling pathway (GO:0038084)2.69459554
61response to host immune response (GO:0052572)2.69104229
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69104229
63positive regulation of humoral immune response (GO:0002922)2.68775807
64regulation of B cell receptor signaling pathway (GO:0050855)2.67046035
65regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.66411399
66regulation of chronic inflammatory response (GO:0002676)2.65709997
67regulation of tolerance induction (GO:0002643)2.65306164
68regulation of T-helper cell differentiation (GO:0045622)2.65278758
69regulation of interleukin-12 production (GO:0032655)2.64799075
70negative regulation of viral genome replication (GO:0045071)2.64526003
71response to peptidoglycan (GO:0032494)2.64026830
72leukocyte aggregation (GO:0070486)2.63880502
73cellular response to interferon-gamma (GO:0071346)2.63244690
74regulation of necroptotic process (GO:0060544)2.62668902
75detection of molecule of bacterial origin (GO:0032490)2.61592970
76interferon-gamma-mediated signaling pathway (GO:0060333)2.60725702
77positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.60121526
78negative regulation of granulocyte differentiation (GO:0030853)2.58411085
79positive regulation of monocyte chemotaxis (GO:0090026)2.58140336
80interferon-gamma secretion (GO:0072643)2.57880335
81regulation of cholesterol storage (GO:0010885)2.56939546
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56802770
83regulation of mast cell degranulation (GO:0043304)2.56192650
84apoptotic cell clearance (GO:0043277)2.55215486
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54420205
86negative regulation of T-helper cell differentiation (GO:0045623)2.54420205
87CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.54008785
88T-helper cell differentiation (GO:0042093)2.54008785
89cellular response to exogenous dsRNA (GO:0071360)2.53968070
90production of molecular mediator involved in inflammatory response (GO:0002532)2.53384715
91negative regulation of interleukin-6 production (GO:0032715)2.52323135
92T-helper 1 type immune response (GO:0042088)2.51074926
93response to interferon-alpha (GO:0035455)2.48102765
94establishment of endothelial barrier (GO:0061028)2.46358776
95positive thymic T cell selection (GO:0045059)2.43533991
96response to host (GO:0075136)2.42922919
97response to host defenses (GO:0052200)2.42922919
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42922919
99response to muramyl dipeptide (GO:0032495)2.42419828
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.42123557
101virion attachment to host cell (GO:0019062)2.42058559
102adhesion of symbiont to host cell (GO:0044650)2.42058559
103mannose metabolic process (GO:0006013)2.41914342
104respiratory burst (GO:0045730)2.41690487
105cellular extravasation (GO:0045123)2.41059185
106adhesion of symbiont to host (GO:0044406)2.39096186
107positive regulation of p38MAPK cascade (GO:1900745)2.38620750
108growth hormone receptor signaling pathway (GO:0060396)2.38254072
109diol metabolic process (GO:0034311)2.37802110
110neutrophil activation (GO:0042119)2.37173250
111regulation of T-helper 1 cell differentiation (GO:0045625)2.35938639
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.34837715
113membrane raft organization (GO:0031579)2.34247712
114leukocyte tethering or rolling (GO:0050901)2.33201369
115leukocyte cell-cell adhesion (GO:0007159)2.32715547
116granulocyte activation (GO:0036230)2.31410476
117macrophage activation (GO:0042116)2.29709401
118response to laminar fluid shear stress (GO:0034616)2.29216427
119positive regulation of histone deacetylation (GO:0031065)2.28877306
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28794369
121sphingomyelin metabolic process (GO:0006684)2.28364470
122surfactant homeostasis (GO:0043129)2.28349826
123regulation of monocyte chemotaxis (GO:0090025)2.26304366
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.24271595
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24069374
126hydrogen peroxide biosynthetic process (GO:0050665)2.22837786
127negative regulation of lipid storage (GO:0010888)2.21744159
128myeloid cell activation involved in immune response (GO:0002275)2.21706218
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.20505862
130* detection of external biotic stimulus (GO:0098581)2.18450980
131positive regulation of natural killer cell differentiation (GO:0032825)2.17839268
132negative regulation of interleukin-12 production (GO:0032695)2.17616924
133heterotypic cell-cell adhesion (GO:0034113)2.16712470
134regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.16318382
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15494641
136amyloid precursor protein catabolic process (GO:0042987)2.14689923
137valine metabolic process (GO:0006573)2.14554430
138* positive regulation of antigen processing and presentation (GO:0002579)2.13875998
139plasma lipoprotein particle clearance (GO:0034381)2.13417875
140regulation of toll-like receptor signaling pathway (GO:0034121)2.12274139
141peptidyl-tyrosine autophosphorylation (GO:0038083)2.11321886
142regulation of cellular extravasation (GO:0002691)2.10341721
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.09997947
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.09404138
145complement activation, alternative pathway (GO:0006957)2.09163695
146cellular response to interferon-beta (GO:0035458)2.09092483
147response to interferon-beta (GO:0035456)2.08862191
148sphingoid metabolic process (GO:0046519)2.08646336
149pinocytosis (GO:0006907)2.08606208
150response to lipoprotein particle (GO:0055094)2.06255013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.76726808
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.91215029
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72511198
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.69423415
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.66391471
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14047928
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.76319541
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72740975
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66012909
10VDR_21846776_ChIP-Seq_THP-1_Human2.61935036
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61168322
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.44441479
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44166385
14RUNX_20019798_ChIP-Seq_JUKART_Human2.31906336
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30305539
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27663906
17GATA1_22025678_ChIP-Seq_K562_Human2.24178440
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19236761
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.17460202
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.15052492
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13658703
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.13197329
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11347630
24MYC_22102868_ChIP-Seq_BL_Human2.07986992
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06775662
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04014250
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94032167
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89452737
29* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86281240
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76431886
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72183031
32KDM2B_26808549_Chip-Seq_DND41_Human1.70441318
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68328021
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65779703
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64904038
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61297990
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.56683478
38CLOCK_20551151_ChIP-Seq_293T_Human1.54952991
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52550315
40MAF_26560356_Chip-Seq_TH2_Human1.50870741
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50573986
42SPI1_23127762_ChIP-Seq_K562_Human1.45604007
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44555636
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.42792859
45LXR_22292898_ChIP-Seq_THP-1_Human1.42509199
46SCL_19346495_ChIP-Seq_HPC-7_Human1.42381293
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40333222
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39933935
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38775373
50GATA1_19941826_ChIP-Seq_K562_Human1.37588726
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37124300
52MYB_26560356_Chip-Seq_TH2_Human1.35284218
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35212555
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.35117088
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34017252
56MAF_26560356_Chip-Seq_TH1_Human1.32609837
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31426591
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26832622
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.26182801
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26126222
61VDR_24787735_ChIP-Seq_THP-1_Human1.25683693
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24169439
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24073124
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23226665
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23011194
66* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22797390
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20118611
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19267425
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.18173679
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17889983
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16357760
72VDR_24763502_ChIP-Seq_THP-1_Human1.15076777
73MYB_26560356_Chip-Seq_TH1_Human1.15059676
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14582333
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14122249
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.13371584
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.12127239
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11388359
79* GATA3_27048872_Chip-Seq_THYMUS_Human1.10784841
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09434508
81GATA2_19941826_ChIP-Seq_K562_Human1.09050269
82* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09036381
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.08884713
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07662098
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07417493
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07296056
87SOX2_20726797_ChIP-Seq_SW620_Human1.07199363
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.07184253
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06555764
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06536068
91* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06111854
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05757614
93UTX_26944678_Chip-Seq_JUKART_Human1.04602378
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04489468
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04295360
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03256980
97GATA3_26560356_Chip-Seq_TH2_Human1.03163542
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.02235876
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.02235876
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02211380
101* SPI1_23547873_ChIP-Seq_NB4_Human1.01701423
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00940391
103PU_27001747_Chip-Seq_BMDM_Mouse1.00633474
104NCOR1_26117541_ChIP-Seq_K562_Human0.99208892
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98899487
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97332884
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.96991272
108CJUN_26792858_Chip-Seq_BT549_Human0.96467062
109SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95638274
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95120692
111RACK7_27058665_Chip-Seq_MCF-7_Human0.94376236
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94330317
113TCF7_22412390_ChIP-Seq_EML_Mouse0.94106574
114* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93144047
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93027353
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92564125
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91570740
118BCL6_27268052_Chip-Seq_Bcells_Human0.91359446
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91215765
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91063682
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89945237
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89760779
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89760779
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89563238
125EGR1_19032775_ChIP-ChIP_M12_Human0.89504059
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89499218
127* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89449450
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88244047
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87702903
130* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87671489
131* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86871817
132* BCOR_27268052_Chip-Seq_Bcells_Human0.84507687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.53688850
2MP0003191_abnormal_cellular_cholesterol3.24702529
3MP0009278_abnormal_bone_marrow3.08998376
4MP0001835_abnormal_antigen_presentation2.46566614
5MP0009785_altered_susceptibility_to2.46023844
6MP0003950_abnormal_plasma_membrane2.37894710
7MP0005451_abnormal_body_composition2.31171293
8* MP0005387_immune_system_phenotype2.24014953
9* MP0001790_abnormal_immune_system2.24014953
10MP0003436_decreased_susceptibility_to2.23302922
11MP0003300_gastrointestinal_ulcer2.17435593
12MP0010368_abnormal_lymphatic_system2.17406663
13* MP0005025_abnormal_response_to2.12012336
14MP0000685_abnormal_immune_system2.10124687
15MP0002148_abnormal_hypersensitivity_rea2.09885817
16* MP0002419_abnormal_innate_immunity2.06365004
17MP0005671_abnormal_response_to1.99939119
18MP0003303_peritoneal_inflammation1.99736593
19MP0005000_abnormal_immune_tolerance1.93913777
20MP0005058_abnormal_lysosome_morphology1.85115418
21MP0001800_abnormal_humoral_immune1.79172183
22MP0006082_CNS_inflammation1.78001046
23MP0004947_skin_inflammation1.74954368
24MP0009840_abnormal_foam_cell1.74256008
25MP0008438_abnormal_cutaneous_collagen1.73517071
26MP0003828_pulmonary_edema1.73052263
27* MP0002452_abnormal_antigen_presenting1.70500508
28* MP0002723_abnormal_immune_serum1.68276398
29MP0004510_myositis1.67743637
30MP0001533_abnormal_skeleton_physiology1.64302780
31MP0008004_abnormal_stomach_pH1.56940047
32MP0005167_abnormal_blood-brain_barrier1.54057421
33MP0001873_stomach_inflammation1.51644373
34MP0001879_abnormal_lymphatic_vessel1.49935957
35* MP0001819_abnormal_immune_cell1.49107297
36* MP0002420_abnormal_adaptive_immunity1.48796687
37MP0001851_eye_inflammation1.46382520
38MP0001845_abnormal_inflammatory_respons1.42431697
39MP0009333_abnormal_splenocyte_physiolog1.42288650
40MP0001545_abnormal_hematopoietic_system1.38538077
41MP0005397_hematopoietic_system_phenotyp1.38538077
42MP0000343_altered_response_to1.37361989
43MP0003566_abnormal_cell_adhesion1.35539632
44MP0005670_abnormal_white_adipose1.35177992
45MP0003091_abnormal_cell_migration1.34593058
46MP0001853_heart_inflammation1.34504073
47MP0002166_altered_tumor_susceptibility1.33239735
48MP0002138_abnormal_hepatobiliary_system1.33038037
49MP0009764_decreased_sensitivity_to1.32273927
50MP0010155_abnormal_intestine_physiology1.31636803
51MP0008469_abnormal_protein_level1.31599700
52MP0005464_abnormal_platelet_physiology1.31311276
53MP0003705_abnormal_hypodermis_morpholog1.28579565
54MP0000689_abnormal_spleen_morphology1.26843400
55MP0003690_abnormal_glial_cell1.24456947
56MP0002722_abnormal_immune_system1.24452302
57MP0002332_abnormal_exercise_endurance1.23943485
58MP0005310_abnormal_salivary_gland1.23011730
59MP0004272_abnormal_basement_membrane1.19654213
60MP0005365_abnormal_bile_salt1.19646600
61MP0003448_altered_tumor_morphology1.18656455
62MP0004147_increased_porphyrin_level1.18631478
63MP0002405_respiratory_system_inflammati1.18033666
64MP0002796_impaired_skin_barrier1.15453840
65MP0004808_abnormal_hematopoietic_stem1.15410962
66MP0002998_abnormal_bone_remodeling1.14705244
67MP0003195_calcinosis1.14300961
68MP0002933_joint_inflammation1.13353211
69MP0002877_abnormal_melanocyte_morpholog1.10825207
70MP0000920_abnormal_myelination1.08554878
71MP0004130_abnormal_muscle_cell1.08539745
72MP0002006_tumorigenesis1.07978099
73MP0009763_increased_sensitivity_to1.07746532
74MP0002837_dystrophic_cardiac_calcinosis1.05729038
75MP0000249_abnormal_blood_vessel1.05213252
76MP0004185_abnormal_adipocyte_glucose1.04967279
77MP0000716_abnormal_immune_system1.04785770
78MP0004782_abnormal_surfactant_physiolog1.04533779
79MP0003453_abnormal_keratinocyte_physiol1.04150831
80MP0005275_abnormal_skin_tensile1.04083738
81MP0003763_abnormal_thymus_physiology1.03025001
82MP0008260_abnormal_autophagy1.00407302
83MP0000609_abnormal_liver_physiology1.00107694
84MP0009643_abnormal_urine_homeostasis0.98779392
85MP0000703_abnormal_thymus_morphology0.98072191
86MP0005076_abnormal_cell_differentiation0.97633501
87MP0001958_emphysema0.96782620
88MP0003045_fibrosis0.96328174
89MP0005390_skeleton_phenotype0.94948727
90MP0000013_abnormal_adipose_tissue0.94240253
91MP0005666_abnormal_adipose_tissue0.94176493
92MP0002139_abnormal_hepatobiliary_system0.93895336
93MP0005166_decreased_susceptibility_to0.91774235
94MP0005375_adipose_tissue_phenotype0.90928555
95MP0005085_abnormal_gallbladder_physiolo0.90869944
96MP0004883_abnormal_blood_vessel0.90491303
97MP0002118_abnormal_lipid_homeostasis0.89570192
98MP0003279_aneurysm0.89103480
99MP0000767_abnormal_smooth_muscle0.86502474
100MP0005164_abnormal_response_to0.86322420
101MP0005023_abnormal_wound_healing0.85080719
102MP0002398_abnormal_bone_marrow0.84772068
103MP0010329_abnormal_lipoprotein_level0.84644280
104MP0003866_abnormal_defecation0.83986950
105MP0005165_increased_susceptibility_to0.83873821
106MP0004381_abnormal_hair_follicle0.82448563
107MP0002396_abnormal_hematopoietic_system0.81923378
108MP0002009_preneoplasia0.81884879
109MP0003075_altered_response_to0.80942904
110MP0003172_abnormal_lysosome_physiology0.80838550
111MP0000858_altered_metastatic_potential0.80498617
112MP0002254_reproductive_system_inflammat0.80494358
113MP0006054_spinal_hemorrhage0.80093000
114MP0000465_gastrointestinal_hemorrhage0.79617893
115MP0002429_abnormal_blood_cell0.79075176
116MP0005360_urolithiasis0.78973179
117MP0001663_abnormal_digestive_system0.78659136
118MP0002295_abnormal_pulmonary_circulatio0.77150542
119MP0003183_abnormal_peptide_metabolism0.77142611
120MP0000604_amyloidosis0.76241825
121MP0003656_abnormal_erythrocyte_physiolo0.73584035
122MP0002132_abnormal_respiratory_system0.73054203
123MP0010307_abnormal_tumor_latency0.67192309
124MP0009115_abnormal_fat_cell0.65877729
125MP0003806_abnormal_nucleotide_metabolis0.65851786
126MP0009765_abnormal_xenobiotic_induced0.65163006

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.38224754
2Eczematoid dermatitis (HP:0000976)4.18416716
3Spontaneous hematomas (HP:0007420)3.94416447
4Abnormality of liposaccharide metabolism (HP:0010968)3.80673337
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.80673337
6Abnormality of glycolipid metabolism (HP:0010969)3.80673337
7Hematochezia (HP:0002573)3.72403813
8Elevated erythrocyte sedimentation rate (HP:0003565)3.50456136
9Systemic lupus erythematosus (HP:0002725)3.45991255
10Recurrent gram-negative bacterial infections (HP:0005420)3.36165721
11Recurrent bacterial skin infections (HP:0005406)3.34300519
12Hypoglycemic coma (HP:0001325)3.32105047
13Axonal loss (HP:0003447)3.32071332
14Chronic otitis media (HP:0000389)3.26659604
15Keratoconjunctivitis sicca (HP:0001097)3.18780168
16Thick nail (HP:0001805)3.18252309
17Abnormality of the nasal mucosa (HP:0000433)3.17491577
18Abnormality of macrophages (HP:0004311)3.16329497
19T lymphocytopenia (HP:0005403)3.13430105
20Increased IgE level (HP:0003212)3.12995754
21Meningitis (HP:0001287)3.11893837
22Autoimmune thrombocytopenia (HP:0001973)3.10897579
23Hypoglycemic seizures (HP:0002173)3.00064951
24Vacuolated lymphocytes (HP:0001922)2.95880267
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.92526910
26Keratoconjunctivitis (HP:0001096)2.87706216
27Chronic obstructive pulmonary disease (HP:0006510)2.83959473
28Obstructive lung disease (HP:0006536)2.83959473
29Interstitial pulmonary disease (HP:0006530)2.80197791
30Myositis (HP:0100614)2.79473366
31Abnormality of B cell number (HP:0010975)2.77548344
32Panhypogammaglobulinemia (HP:0003139)2.74731269
33Colitis (HP:0002583)2.70746562
34Dysostosis multiplex (HP:0000943)2.69428426
35Nonimmune hydrops fetalis (HP:0001790)2.68450026
36Gastrointestinal infarctions (HP:0005244)2.66817458
37Recurrent cutaneous fungal infections (HP:0011370)2.63688324
38Chronic mucocutaneous candidiasis (HP:0002728)2.63688324
39B lymphocytopenia (HP:0010976)2.62214898
40Pustule (HP:0200039)2.60210057
41Granulocytopenia (HP:0001913)2.59529409
42Increased IgM level (HP:0003496)2.58618994
43Hemorrhage of the eye (HP:0011885)2.55604485
44Stomatitis (HP:0010280)2.54607615
45Leukocytosis (HP:0001974)2.54533952
46Mediastinal lymphadenopathy (HP:0100721)2.54175617
47Joint hemorrhage (HP:0005261)2.53905361
48Myocardial infarction (HP:0001658)2.53355241
49Hyperinsulinemic hypoglycemia (HP:0000825)2.52938860
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52221401
51Nasal polyposis (HP:0100582)2.51674039
52Autoimmune hemolytic anemia (HP:0001890)2.50057444
53Encephalitis (HP:0002383)2.49530663
54Prolonged bleeding time (HP:0003010)2.45748327
55Arterial thrombosis (HP:0004420)2.45350367
56Prolonged partial thromboplastin time (HP:0003645)2.45055339
57Esophageal varix (HP:0002040)2.44855842
58Complement deficiency (HP:0004431)2.44368208
59Orchitis (HP:0100796)2.43922214
60Abnormality of the common coagulation pathway (HP:0010990)2.43460827
61Glomerulonephritis (HP:0000099)2.38482288
62Symptomatic seizures (HP:0011145)2.38129123
63Hypergammaglobulinemia (HP:0010702)2.37343493
64Abnormality of the intrinsic pathway (HP:0010989)2.36915942
65Chest pain (HP:0100749)2.35923244
66Recurrent skin infections (HP:0001581)2.33674707
67Agammaglobulinemia (HP:0004432)2.33160219
68Gastrointestinal stroma tumor (HP:0100723)2.32892480
69Inflammation of the large intestine (HP:0002037)2.31759275
70Increased cerebral lipofuscin (HP:0011813)2.31191087
71Mucopolysacchariduria (HP:0008155)2.31152932
72Urinary glycosaminoglycan excretion (HP:0003541)2.31152932
73Nephritis (HP:0000123)2.29687429
74Polycythemia (HP:0001901)2.28946138
75Eosinophilia (HP:0001880)2.28921925
76Pancreatic islet-cell hyperplasia (HP:0004510)2.27574621
77Pulmonary infiltrates (HP:0002113)2.26543230
78Periodontitis (HP:0000704)2.26288629
79Gingivitis (HP:0000230)2.25476747
80Abnormality of complement system (HP:0005339)2.24652233
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.19485210
82Abnormality of T cells (HP:0002843)2.19344872
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.18344860
84Osteolytic defects of the hand bones (HP:0009699)2.18344860
85Amyloidosis (HP:0011034)2.18321587
86Mitral stenosis (HP:0001718)2.16015262
87Recurrent bronchitis (HP:0002837)2.15222160
88Gangrene (HP:0100758)2.14923283
89Gastrointestinal inflammation (HP:0004386)2.13468900
90Xanthomatosis (HP:0000991)2.13343092
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13144542
92Abnormality of polysaccharide metabolism (HP:0011012)2.13144542
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13144542
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12739671
95Facial diplegia (HP:0001349)2.11566553
96Vasculitis (HP:0002633)2.10636221
97Urticaria (HP:0001025)2.10581924
98Deep venous thrombosis (HP:0002625)2.09208764
99Abnormality of the peritoneum (HP:0002585)2.08860199
100Abnormality of the pleura (HP:0002103)2.06652128
101Pulmonary embolism (HP:0002204)2.06494297
102Recurrent viral infections (HP:0004429)2.05787598
103Peritonitis (HP:0002586)2.04855103
104Asymmetric septal hypertrophy (HP:0001670)2.03686446
105Vertigo (HP:0002321)2.02991220
106IgA deficiency (HP:0002720)2.02198032
107Abnormality of the endocardium (HP:0004306)2.02121731
108Emphysema (HP:0002097)2.01833118
109Spondylolisthesis (HP:0003302)2.01691117
110Restrictive lung disease (HP:0002091)2.00635737
111Recurrent fungal infections (HP:0002841)2.00614929
112Hyporeflexia of lower limbs (HP:0002600)2.00502474
113Petechiae (HP:0000967)1.99511862
114Severe combined immunodeficiency (HP:0004430)1.97760345
115Ileus (HP:0002595)1.97596774
116Anorexia (HP:0002039)1.96087411
117Viral hepatitis (HP:0006562)1.95884393
118Muscle fiber splitting (HP:0003555)1.95853345
119Loss of speech (HP:0002371)1.95723289
120Polyneuropathy (HP:0001271)1.95633284
121Increased serum ferritin (HP:0003281)1.94683127
122Hemoptysis (HP:0002105)1.94129920
123Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94020238
124Sepsis (HP:0100806)1.93988340
125Abnormality of the fingertips (HP:0001211)1.93362898
126Polygenic inheritance (HP:0010982)1.93207644
127Ketoacidosis (HP:0001993)1.91352665
128Combined immunodeficiency (HP:0005387)1.91066241
129Insulin-resistant diabetes mellitus (HP:0000831)1.90799297
130Gingival bleeding (HP:0000225)1.89927479
131Increased CSF protein (HP:0002922)1.89285532
132Ventricular tachycardia (HP:0004756)1.88688661
133Hyperglycemia (HP:0003074)1.85129227
134Anhidrosis (HP:0000970)1.84755943
135Insulin resistance (HP:0000855)1.84426323
136Increased connective tissue (HP:0009025)1.83389181
137Cellulitis (HP:0100658)1.83205769
138Generalized aminoaciduria (HP:0002909)1.82456806
139Acanthosis nigricans (HP:0000956)1.81644254
140Optic neuritis (HP:0100653)1.81391914
141Retrobulbar optic neuritis (HP:0100654)1.81391914
142Stroke (HP:0001297)1.79988477
143Epistaxis (HP:0000421)1.78233141
144Purpura (HP:0000979)1.76758494
145Cerebral hemorrhage (HP:0001342)1.76182118
146Conjunctival telangiectasia (HP:0000524)1.75734761
147Osteomyelitis (HP:0002754)1.75293319
148Intrahepatic cholestasis (HP:0001406)1.73255625
149Hepatosplenomegaly (HP:0001433)1.71958006
150Abnormality of T cell number (HP:0011839)1.71640958
151Hyperlipoproteinemia (HP:0010980)1.71462841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.40328848
2TYK23.00635170
3ERN12.89678768
4TIE12.89563806
5EPHB12.86010909
6MAP4K12.70235029
7MAP3K142.66309105
8PRPF4B2.59351458
9JAK12.29508802
10IRAK32.27760347
11KDR2.27350904
12TBK12.21621315
13NLK2.17442579
14FGFR42.17168866
15JAK32.10242588
16TGFBR22.10072794
17CSK2.08711586
18IKBKE2.06042306
19BLK1.96329071
20TTN1.91937539
21IRAK41.90458796
22ITK1.54520448
23ZAP701.45628484
24MAP3K131.41535419
25IKBKB1.41129289
26KIT1.37891080
27TAOK21.37308405
28TXK1.30329103
29CDC42BPA1.30059521
30EPHA31.28164455
31RIPK11.27556577
32MATK1.26689978
33STK101.26379738
34TNK21.24786092
35GRK11.19067518
36GRK61.18866662
37TESK21.18616481
38TRIB31.17441105
39MAP3K111.17127235
40TRPM71.16819027
41PTK61.16572087
42PKN11.13845278
43SIK11.12744327
44JAK21.11640602
45CAMK1D1.09402693
46NME21.06285799
47MOS1.04638120
48MET1.04382371
49TAOK31.03500402
50MAPK151.00008461
51TEC0.99849624
52FGFR30.99190771
53PRKCH0.97952979
54BMPR20.93665172
55MST1R0.92525185
56LCK0.86967409
57HCK0.86573002
58LRRK20.84064851
59MARK30.83549188
60BTK0.82879573
61IRAK10.81651116
62FLT30.81468776
63TAOK10.79622369
64CHUK0.79577296
65MST40.78969407
66MAP2K30.77857459
67MYLK0.77407600
68CDK60.75378939
69MAP3K60.73711502
70MAPK70.71962269
71STK390.71118909
72CDK120.70442683
73RPS6KC10.70202851
74RPS6KL10.70202851
75CDK40.68784130
76DDR20.67577619
77MAP2K20.66933231
78PRKG20.66588504
79PIK3CG0.66256823
80BCKDK0.66089143
81FRK0.65108795
82PIM10.63912445
83SYK0.63316929
84CSF1R0.63299009
85MAPK110.63012894
86PRKCQ0.60671143
87HIPK20.60458162
88RPS6KA60.57951608
89PRKD10.57907938
90CAMK1G0.57597921
91FES0.57516875
92PDK10.56969120
93MAP3K10.56818492
94BMX0.56744283
95PIM20.55946960
96GSK3A0.55209809
97IGF1R0.55078065
98PTK20.53487865
99GRK70.52805516
100PRKAA20.52407964
101LYN0.52236039
102RIPK40.51076255
103SIK30.50826421
104SMG10.50789228
105PDGFRA0.50733547
106MAP3K30.50545630
107MAP3K50.50509534
108MELK0.49736988
109DMPK0.48154549
110ABL10.47768569
111NEK90.47294950
112ICK0.47218481
113MAP3K70.47079852
114MARK20.46991157
115PDGFRB0.46934770
116STK240.46734804
117CLK10.45914396
118RPS6KA20.44815138
119WNK40.43710544
120PDPK10.42668759
121FGR0.42549902
122MAPK40.41742318
123MAP2K60.41593564
124INSR0.41344589
125EGFR0.40525856
126TGFBR10.40119013
127RET0.40075779
128IRAK20.38383122
129MAPK120.36742715
130PRKD20.36316205
131WNK10.34179917
132PKN20.33966454

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.32616081
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.15967195
3Leishmaniasis_Homo sapiens_hsa051402.13679366
4Malaria_Homo sapiens_hsa051442.04616839
5Caffeine metabolism_Homo sapiens_hsa002321.91138248
6Graft-versus-host disease_Homo sapiens_hsa053321.88988274
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82073933
8Osteoclast differentiation_Homo sapiens_hsa043801.68586259
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.65042229
10Complement and coagulation cascades_Homo sapiens_hsa046101.64915263
11Lysosome_Homo sapiens_hsa041421.56707927
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.54575013
13Measles_Homo sapiens_hsa051621.54434640
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.49392856
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48245796
16* Pertussis_Homo sapiens_hsa051331.46449085
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44364086
18Other glycan degradation_Homo sapiens_hsa005111.43901100
19Toxoplasmosis_Homo sapiens_hsa051451.41201120
20B cell receptor signaling pathway_Homo sapiens_hsa046621.38471966
21TNF signaling pathway_Homo sapiens_hsa046681.35116556
22Rheumatoid arthritis_Homo sapiens_hsa053231.33469331
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.33188934
24ABC transporters_Homo sapiens_hsa020101.32894251
25Hepatitis C_Homo sapiens_hsa051601.29549908
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29170124
27Sphingolipid metabolism_Homo sapiens_hsa006001.28547609
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.28345001
29Fatty acid degradation_Homo sapiens_hsa000711.24884809
30PPAR signaling pathway_Homo sapiens_hsa033201.23759769
31* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20153315
32Hematopoietic cell lineage_Homo sapiens_hsa046401.19926165
33Primary immunodeficiency_Homo sapiens_hsa053401.19653466
34Fatty acid elongation_Homo sapiens_hsa000621.18195845
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17739568
36Influenza A_Homo sapiens_hsa051641.17273483
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16002912
38African trypanosomiasis_Homo sapiens_hsa051431.15574532
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13877663
40Antigen processing and presentation_Homo sapiens_hsa046121.12894264
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11986207
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11647274
43Tuberculosis_Homo sapiens_hsa051521.10496429
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.08705766
45Chemokine signaling pathway_Homo sapiens_hsa040621.08671389
46Tryptophan metabolism_Homo sapiens_hsa003801.08590564
47Fatty acid metabolism_Homo sapiens_hsa012121.06204645
48Amoebiasis_Homo sapiens_hsa051461.05039931
49Histidine metabolism_Homo sapiens_hsa003401.04005299
50Insulin resistance_Homo sapiens_hsa049311.03636325
51Legionellosis_Homo sapiens_hsa051341.03316780
52Allograft rejection_Homo sapiens_hsa053301.03056365
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98079334
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95601796
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.93881595
56Viral myocarditis_Homo sapiens_hsa054160.92889647
57T cell receptor signaling pathway_Homo sapiens_hsa046600.89219493
58Apoptosis_Homo sapiens_hsa042100.88174461
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87295113
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86157888
61VEGF signaling pathway_Homo sapiens_hsa043700.84510293
62Peroxisome_Homo sapiens_hsa041460.82837571
63Acute myeloid leukemia_Homo sapiens_hsa052210.82474453
64Folate biosynthesis_Homo sapiens_hsa007900.81747322
65Focal adhesion_Homo sapiens_hsa045100.78914180
66ECM-receptor interaction_Homo sapiens_hsa045120.78006678
67HTLV-I infection_Homo sapiens_hsa051660.77364693
68Platelet activation_Homo sapiens_hsa046110.76099253
69Herpes simplex infection_Homo sapiens_hsa051680.75400590
70Epstein-Barr virus infection_Homo sapiens_hsa051690.74844651
71Salmonella infection_Homo sapiens_hsa051320.73912167
72Phagosome_Homo sapiens_hsa041450.72950876
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71076843
74Type II diabetes mellitus_Homo sapiens_hsa049300.69719362
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69344320
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.68800722
77Sulfur metabolism_Homo sapiens_hsa009200.68001981
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66840250
79Non-small cell lung cancer_Homo sapiens_hsa052230.66015143
80Bladder cancer_Homo sapiens_hsa052190.63754428
81Autoimmune thyroid disease_Homo sapiens_hsa053200.62068740
82Viral carcinogenesis_Homo sapiens_hsa052030.58795683
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.57908890
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57842463
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57451281
86beta-Alanine metabolism_Homo sapiens_hsa004100.57168246
87Propanoate metabolism_Homo sapiens_hsa006400.56372758
88Prion diseases_Homo sapiens_hsa050200.55524575
89* Shigellosis_Homo sapiens_hsa051310.55438351
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54935604
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53321538
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.52472841
93Small cell lung cancer_Homo sapiens_hsa052220.51932744
94Hepatitis B_Homo sapiens_hsa051610.51671091
95FoxO signaling pathway_Homo sapiens_hsa040680.50543127
96Arginine biosynthesis_Homo sapiens_hsa002200.50123243
97Pancreatic cancer_Homo sapiens_hsa052120.50070452
98Prolactin signaling pathway_Homo sapiens_hsa049170.49043070
99HIF-1 signaling pathway_Homo sapiens_hsa040660.48622667
100* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47631524
101Chronic myeloid leukemia_Homo sapiens_hsa052200.47057226
102Dorso-ventral axis formation_Homo sapiens_hsa043200.46086036
103Lysine degradation_Homo sapiens_hsa003100.45434019
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44761966
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44438915
106Endocytosis_Homo sapiens_hsa041440.44024068
107Adherens junction_Homo sapiens_hsa045200.43154342
108Notch signaling pathway_Homo sapiens_hsa043300.42887106
109Fatty acid biosynthesis_Homo sapiens_hsa000610.42318706
110Type I diabetes mellitus_Homo sapiens_hsa049400.42139958
111Renal cell carcinoma_Homo sapiens_hsa052110.41810887
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41377165
113mTOR signaling pathway_Homo sapiens_hsa041500.41233393
114Systemic lupus erythematosus_Homo sapiens_hsa053220.40877820
115Starch and sucrose metabolism_Homo sapiens_hsa005000.40509251
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39429706
117Asthma_Homo sapiens_hsa053100.38241747
118MAPK signaling pathway_Homo sapiens_hsa040100.34614560
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33412951
120Prostate cancer_Homo sapiens_hsa052150.31249463
121GnRH signaling pathway_Homo sapiens_hsa049120.29436261
122Proteoglycans in cancer_Homo sapiens_hsa052050.27648710
123Inositol phosphate metabolism_Homo sapiens_hsa005620.27266345
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26584353
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26261884
126Choline metabolism in cancer_Homo sapiens_hsa052310.26167102
127Thyroid cancer_Homo sapiens_hsa052160.25951361

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