NOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* positive regulation by organism of defense response of other organism involved in symbiotic interact6.06772381
2* modulation by symbiont of host immune response (GO:0052553)6.06772381
3* positive regulation by symbiont of host defense response (GO:0052509)6.06772381
4* modulation by symbiont of host defense response (GO:0052031)6.06772381
5* modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.06772381
6* modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.06772381
7negative regulation of cell killing (GO:0031342)5.60544338
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.60544338
9* response to peptidoglycan (GO:0032494)5.18020756
10* detection of other organism (GO:0098543)4.76820990
11neutrophil activation involved in immune response (GO:0002283)4.62461319
12* response to host immune response (GO:0052572)4.52610911
13* response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.52610911
14positive regulation of interferon-alpha production (GO:0032727)4.39346422
15* detection of bacterium (GO:0016045)4.38383839
16superoxide anion generation (GO:0042554)4.35962542
17NIK/NF-kappaB signaling (GO:0038061)4.31644944
18* macrophage activation involved in immune response (GO:0002281)4.24111516
19regulation of interferon-alpha production (GO:0032647)4.22513185
20* detection of external biotic stimulus (GO:0098581)4.19576639
21regulation of interferon-beta biosynthetic process (GO:0045357)4.17998629
22* response to host (GO:0075136)4.12763796
23* response to host defenses (GO:0052200)4.12763796
24* response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.12763796
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12546269
26* response to muramyl dipeptide (GO:0032495)4.07506085
27positive regulation of heat generation (GO:0031652)4.07104387
28positive regulation of chemokine biosynthetic process (GO:0045080)4.06042832
29type I interferon signaling pathway (GO:0060337)3.95348990
30cellular response to type I interferon (GO:0071357)3.95348990
31immunoglobulin mediated immune response (GO:0016064)3.94649894
32response to type I interferon (GO:0034340)3.92946919
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.90946805
34granulocyte activation (GO:0036230)3.83089480
35neutrophil activation (GO:0042119)3.82018830
36respiratory burst (GO:0045730)3.78603852
37I-kappaB phosphorylation (GO:0007252)3.78240096
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77943228
39hydrogen peroxide biosynthetic process (GO:0050665)3.69848122
40regulation of fever generation (GO:0031620)3.69111237
41interferon-gamma-mediated signaling pathway (GO:0060333)3.65438798
42* regulation of gamma-delta T cell activation (GO:0046643)3.64344151
43positive regulation of toll-like receptor signaling pathway (GO:0034123)3.62994793
44* positive regulation of cellular amide metabolic process (GO:0034250)3.59520845
45leukocyte aggregation (GO:0070486)3.58606728
46neutrophil mediated immunity (GO:0002446)3.58296476
47germinal center formation (GO:0002467)3.57482911
48* negative regulation of lymphocyte mediated immunity (GO:0002707)3.54419006
49positive regulation of interferon-beta production (GO:0032728)3.51300819
50regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.50785834
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50576105
52regulation of chemokine biosynthetic process (GO:0045073)3.46804512
53regulation of T cell tolerance induction (GO:0002664)3.46047211
54production of molecular mediator involved in inflammatory response (GO:0002532)3.45170887
55regulation of tolerance induction (GO:0002643)3.43111463
56positive regulation of mast cell degranulation (GO:0043306)3.39803995
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.39803995
58negative regulation of viral genome replication (GO:0045071)3.36133638
59response to protozoan (GO:0001562)3.35183094
60* positive regulation of gamma-delta T cell activation (GO:0046645)3.33849834
61regulation of T-helper 2 cell differentiation (GO:0045628)3.32295896
62regulation of mast cell degranulation (GO:0043304)3.29516023
63B cell receptor signaling pathway (GO:0050853)3.29189227
64leukocyte migration involved in inflammatory response (GO:0002523)3.27627522
65regulation of interleukin-12 biosynthetic process (GO:0045075)3.27380932
66reactive oxygen species biosynthetic process (GO:1903409)3.26903165
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26589561
68regulation of heat generation (GO:0031650)3.24790303
69modulation by symbiont of host cellular process (GO:0044068)3.22365441
70response to interleukin-15 (GO:0070672)3.20925820
71regulation of gamma-delta T cell differentiation (GO:0045586)3.20489121
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.20155604
73antigen processing and presentation of endogenous antigen (GO:0019883)3.19927246
74regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.19898359
75positive regulation of mast cell activation (GO:0033005)3.19232482
76* negative regulation of leukocyte mediated immunity (GO:0002704)3.18150242
77negative regulation of cytokine production involved in immune response (GO:0002719)3.15224686
78* microglial cell activation (GO:0001774)3.14688920
79negative regulation of erythrocyte differentiation (GO:0045647)3.14157168
80regulation of mast cell activation involved in immune response (GO:0033006)3.12580661
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11205025
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11205025
83* detection of molecule of bacterial origin (GO:0032490)3.10493712
84antigen processing and presentation via MHC class Ib (GO:0002475)3.09596453
85regulation of leukocyte degranulation (GO:0043300)3.08774208
86regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.08402518
87positive regulation of NF-kappaB import into nucleus (GO:0042346)3.07851308
88* negative regulation of interleukin-12 production (GO:0032695)3.07406898
89cytokine secretion (GO:0050663)3.07400507
90regulation of mast cell activation (GO:0033003)3.07164332
91regulation of B cell receptor signaling pathway (GO:0050855)3.05965941
92* negative regulation of T cell mediated immunity (GO:0002710)3.04719127
93regulation of T-helper 1 cell differentiation (GO:0045625)3.04560669
94* macrophage activation (GO:0042116)3.02734846
95regulation of interleukin-8 biosynthetic process (GO:0045414)3.01839506
96natural killer cell mediated cytotoxicity (GO:0042267)3.01088510
97natural killer cell mediated immunity (GO:0002228)3.01088510
98positive regulation of B cell differentiation (GO:0045579)3.01037431
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00466168
100* positive regulation of interleukin-12 production (GO:0032735)2.99937263
101negative regulation of mast cell activation (GO:0033004)2.99881034
102* positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98152852
103response to interferon-alpha (GO:0035455)2.97966282
104positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.96634832
105T-helper 1 type immune response (GO:0042088)2.96615459
106* myeloid cell activation involved in immune response (GO:0002275)2.96277804
107negative regulation of interleukin-6 production (GO:0032715)2.96150221
108T cell migration (GO:0072678)2.96143245
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.96093181
110positive regulation of chemokine production (GO:0032722)2.92932018
111negative regulation of innate immune response (GO:0045824)2.92000618
112cellular extravasation (GO:0045123)2.91355754
113positive regulation of tolerance induction (GO:0002645)2.91247815
114leukocyte degranulation (GO:0043299)2.91119602
115tolerance induction (GO:0002507)2.91118964
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90713575
117cellular response to interleukin-15 (GO:0071350)2.90474009
118regulation of B cell differentiation (GO:0045577)2.89881820
119* myeloid leukocyte activation (GO:0002274)2.88271294
120defense response to protozoan (GO:0042832)2.85845319
121leukocyte mediated cytotoxicity (GO:0001909)2.85655986
122negative regulation of interleukin-17 production (GO:0032700)2.83435229
123positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.83225477
124negative thymic T cell selection (GO:0045060)2.82881259
125positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82407532
126B cell mediated immunity (GO:0019724)2.80205349
127regulation of mononuclear cell migration (GO:0071675)2.77277063
128regulation of alpha-beta T cell proliferation (GO:0046640)2.76967007
129* positive regulation of antigen processing and presentation (GO:0002579)2.76711073
130regulation of RIG-I signaling pathway (GO:0039535)2.75809688
131* detection of biotic stimulus (GO:0009595)2.75451926
132regulation of integrin activation (GO:0033623)2.75107543
133regulation of podosome assembly (GO:0071801)2.74659990
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74309172
135myeloid leukocyte mediated immunity (GO:0002444)2.72608030
136adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.70799869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.55038025
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.43588632
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.69455399
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.33638293
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04842344
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.02758925
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00102645
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.84556634
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.47224888
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42149216
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12980647
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.92148725
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85864042
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82802356
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81174559
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.63742216
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.57289372
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48525238
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28686853
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22101640
21MYC_22102868_ChIP-Seq_BL_Human2.06974518
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96366415
23SCL_19346495_ChIP-Seq_HPC-7_Human1.93827436
24UTX_26944678_Chip-Seq_JUKART_Human1.86961606
25* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84561061
26TCF7_22412390_ChIP-Seq_EML_Mouse1.81765195
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79904861
28VDR_24787735_ChIP-Seq_THP-1_Human1.79321659
29GATA1_22025678_ChIP-Seq_K562_Human1.78904138
30RUNX_20019798_ChIP-Seq_JUKART_Human1.77765259
31* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75377453
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.69710928
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69308332
34SPI1_23547873_ChIP-Seq_NB4_Human1.63875185
35PU_27001747_Chip-Seq_BMDM_Mouse1.63380036
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61811254
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57588176
38* MAF_26560356_Chip-Seq_TH2_Human1.55107216
39KDM2B_26808549_Chip-Seq_DND41_Human1.53333555
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48794606
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47873990
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47702789
43* SPI1_23127762_ChIP-Seq_K562_Human1.46354461
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42792557
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40161021
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37776569
47* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35659395
48MYB_26560356_Chip-Seq_TH2_Human1.33034475
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31609400
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30449916
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24361935
52* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23573636
53VDR_24763502_ChIP-Seq_THP-1_Human1.22952530
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.21036101
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.16667140
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12073259
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11075836
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10569365
59GATA1_19941826_ChIP-Seq_K562_Human1.10449047
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09766146
61MAF_26560356_Chip-Seq_TH1_Human1.09548959
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08341101
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07661860
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07231201
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07105436
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07073560
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06467031
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05574622
69LXR_22292898_ChIP-Seq_THP-1_Human1.03083361
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.02760404
71GATA3_26560356_Chip-Seq_TH2_Human1.02631672
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02365479
73MYB_26560356_Chip-Seq_TH1_Human1.02300014
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00808592
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00577976
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00160098
77* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99244511
78ESR1_21235772_ChIP-Seq_MCF-7_Human0.98124008
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96461594
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96278849
81* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95008399
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94074172
83* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92503464
84GATA3_27048872_Chip-Seq_THYMUS_Human0.92448933
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92265059
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91486637
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91428794
88* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91358605
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90787289
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90498622
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89613428
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88676462
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88676462
94GATA2_19941826_ChIP-Seq_K562_Human0.88214805
95CJUN_26792858_Chip-Seq_BT549_Human0.88189397
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.87214791
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85118544
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.84100751
99BCL6_27268052_Chip-Seq_Bcells_Human0.83078350
100BCOR_27268052_Chip-Seq_Bcells_Human0.82728377
101EZH2_27294783_Chip-Seq_NPCs_Mouse0.82093902
102PU1_27457419_Chip-Seq_LIVER_Mouse0.81476975
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81266569
104NCOR1_26117541_ChIP-Seq_K562_Human0.80506991
105GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80341244
106VDR_21846776_ChIP-Seq_THP-1_Human0.80037820
107STAT3_18555785_Chip-Seq_ESCs_Mouse0.79084866
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78461995
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78153886
110GBX2_23144817_ChIP-Seq_PC3_Human0.78094091
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77783280
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77652461
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76504636
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76116227
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75634148
116* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75601354
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74185044
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73733814
119P53_22387025_ChIP-Seq_ESCs_Mouse0.72452724
120* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72391786
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.70976147
122EGR1_19032775_ChIP-ChIP_M12_Human0.70664895
123NMYC_18555785_Chip-Seq_ESCs_Mouse0.69908014
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69737325
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69665912
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69355393
127SOX2_20726797_ChIP-Seq_SW620_Human0.69099285
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.69013486
129SMRT_27268052_Chip-Seq_Bcells_Human0.68426050
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.68336235
131* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68311345
132SPI1_20517297_ChIP-Seq_HL60_Human0.67734590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.33470290
2MP0003436_decreased_susceptibility_to3.70833473
3* MP0009785_altered_susceptibility_to3.60827466
4MP0003303_peritoneal_inflammation3.55836938
5* MP0002419_abnormal_innate_immunity3.20613410
6MP0002148_abnormal_hypersensitivity_rea3.20151480
7MP0005000_abnormal_immune_tolerance3.08096866
8MP0000569_abnormal_digit_pigmentation2.96177189
9* MP0001790_abnormal_immune_system2.91548936
10* MP0005387_immune_system_phenotype2.91548936
11* MP0005025_abnormal_response_to2.88710566
12MP0004510_myositis2.85673645
13* MP0002452_abnormal_antigen_presenting2.68652642
14MP0003724_increased_susceptibility_to2.63605039
15* MP0001800_abnormal_humoral_immune2.57725367
16* MP0002723_abnormal_immune_serum2.45232416
17MP0009278_abnormal_bone_marrow2.44146841
18MP0006082_CNS_inflammation2.31233521
19MP0005671_abnormal_response_to2.30477510
20MP0002254_reproductive_system_inflammat2.27254474
21MP0004947_skin_inflammation2.24899463
22* MP0001819_abnormal_immune_cell2.23596939
23* MP0000685_abnormal_immune_system2.20166629
24* MP0002420_abnormal_adaptive_immunity2.19635294
25MP0001533_abnormal_skeleton_physiology2.03066507
26MP0009764_decreased_sensitivity_to1.96444588
27MP0003191_abnormal_cellular_cholesterol1.96334563
28MP0003183_abnormal_peptide_metabolism1.92654520
29MP0005464_abnormal_platelet_physiology1.92560146
30MP0001853_heart_inflammation1.85794374
31MP0002405_respiratory_system_inflammati1.84736141
32MP0005174_abnormal_tail_pigmentation1.77675539
33MP0003172_abnormal_lysosome_physiology1.75706696
34* MP0001845_abnormal_inflammatory_respons1.75193690
35MP0005058_abnormal_lysosome_morphology1.69583039
36MP0003448_altered_tumor_morphology1.67840025
37MP0000015_abnormal_ear_pigmentation1.67528773
38* MP0010155_abnormal_intestine_physiology1.66620516
39MP0002277_abnormal_respiratory_mucosa1.65592495
40MP0002998_abnormal_bone_remodeling1.64151733
41MP0000343_altered_response_to1.59012241
42* MP0000716_abnormal_immune_system1.52362206
43* MP0002398_abnormal_bone_marrow1.45629218
44MP0005310_abnormal_salivary_gland1.44267852
45MP0002132_abnormal_respiratory_system1.44033906
46MP0001545_abnormal_hematopoietic_system1.40599874
47MP0005397_hematopoietic_system_phenotyp1.40599874
48MP0002006_tumorigenesis1.37857194
49* MP0008469_abnormal_protein_level1.36545951
50MP0004782_abnormal_surfactant_physiolog1.34490293
51MP0003075_altered_response_to1.33687057
52MP0000566_synostosis1.30423872
53MP0008004_abnormal_stomach_pH1.27318634
54MP0004381_abnormal_hair_follicle1.25256579
55MP0005390_skeleton_phenotype1.23456888
56MP0003453_abnormal_keratinocyte_physiol1.21700515
57MP0003866_abnormal_defecation1.20814681
58MP0001873_stomach_inflammation1.19275183
59MP0009333_abnormal_splenocyte_physiolog1.18670591
60MP0000858_altered_metastatic_potential1.18026922
61MP0000689_abnormal_spleen_morphology1.17183937
62MP0002933_joint_inflammation1.17027129
63* MP0002429_abnormal_blood_cell1.16909548
64MP0000383_abnormal_hair_follicle1.12036538
65MP0003941_abnormal_skin_development1.11456747
66MP0003690_abnormal_glial_cell1.11288060
67MP0003763_abnormal_thymus_physiology1.11013503
68MP0000371_diluted_coat_color1.09400732
69MP0005167_abnormal_blood-brain_barrier1.09381186
70MP0003300_gastrointestinal_ulcer1.08181215
71MP0005257_abnormal_intraocular_pressure1.08119109
72MP0001851_eye_inflammation1.06467676
73MP0005166_decreased_susceptibility_to1.01154180
74MP0003656_abnormal_erythrocyte_physiolo0.99732408
75* MP0002722_abnormal_immune_system0.99336151
76MP0003828_pulmonary_edema0.99036279
77MP0002138_abnormal_hepatobiliary_system0.95129017
78MP0002166_altered_tumor_susceptibility0.92825090
79MP0005076_abnormal_cell_differentiation0.91556306
80MP0000767_abnormal_smooth_muscle0.88581381
81MP0005164_abnormal_response_to0.85712792
82MP0003045_fibrosis0.85149663
83MP0002332_abnormal_exercise_endurance0.85136413
84MP0003136_yellow_coat_color0.83560864
85MP0000465_gastrointestinal_hemorrhage0.81869063
86MP0000490_abnormal_crypts_of0.81863735
87MP0001663_abnormal_digestive_system0.79968896
88MP0003806_abnormal_nucleotide_metabolis0.78563702
89MP0009840_abnormal_foam_cell0.77574094
90MP0003091_abnormal_cell_migration0.76994885
91MP0001958_emphysema0.75552198
92MP0004808_abnormal_hematopoietic_stem0.73776194
93MP0003566_abnormal_cell_adhesion0.71625317
94* MP0009763_increased_sensitivity_to0.71513244
95MP0003795_abnormal_bone_structure0.70897577
96MP0001191_abnormal_skin_condition0.70674692
97MP0004858_abnormal_nervous_system0.70555950
98MP0000604_amyloidosis0.70480328
99MP0002396_abnormal_hematopoietic_system0.68700451
100MP0005171_absent_coat_pigmentation0.66880130
101MP0008874_decreased_physiological_sensi0.66332675
102MP0003221_abnormal_cardiomyocyte_apopto0.64454888
103MP0001216_abnormal_epidermal_layer0.62744158
104MP0002009_preneoplasia0.62487803
105MP0005197_abnormal_uvea_morphology0.62381338
106MP0005451_abnormal_body_composition0.61866289
107* MP0009765_abnormal_xenobiotic_induced0.61419557
108MP0009697_abnormal_copulation0.60961827
109MP0000249_abnormal_blood_vessel0.60123104
110MP0004883_abnormal_blood_vessel0.56434748
111* MP0008260_abnormal_autophagy0.55864480
112MP0002095_abnormal_skin_pigmentation0.55658392
113MP0005075_abnormal_melanosome_morpholog0.55197715
114MP0001879_abnormal_lymphatic_vessel0.54854844
115MP0000703_abnormal_thymus_morphology0.54470438
116MP0005023_abnormal_wound_healing0.52501862
117MP0000627_abnormal_mammary_gland0.51810679
118MP0000920_abnormal_myelination0.49953837
119MP0006054_spinal_hemorrhage0.49228912
120MP0000609_abnormal_liver_physiology0.46872524
121MP0005319_abnormal_enzyme/_coenzyme0.45983416

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.16342056
2Recurrent bacterial skin infections (HP:0005406)6.50426693
3Eczematoid dermatitis (HP:0000976)6.38003820
4Mediastinal lymphadenopathy (HP:0100721)5.32750891
5Recurrent gram-negative bacterial infections (HP:0005420)4.94869547
6Stomatitis (HP:0010280)4.76404929
7Elevated erythrocyte sedimentation rate (HP:0003565)4.52518916
8Gingivitis (HP:0000230)4.21615406
9* Abnormality of macrophages (HP:0004311)4.16879454
10Prostate neoplasm (HP:0100787)4.10160567
11Recurrent skin infections (HP:0001581)3.87303221
12Thick nail (HP:0001805)3.86325140
13Obstructive lung disease (HP:0006536)3.82013393
14Chronic obstructive pulmonary disease (HP:0006510)3.82013393
15Recurrent fungal infections (HP:0002841)3.71722570
16* Myositis (HP:0100614)3.41666649
17Periodontitis (HP:0000704)3.37100275
18* Vasculitis (HP:0002633)3.32025880
19Spontaneous hematomas (HP:0007420)3.31527579
20* Retrobulbar optic neuritis (HP:0100654)3.31169956
21* Optic neuritis (HP:0100653)3.31169956
22Autoimmune thrombocytopenia (HP:0001973)3.29563827
23* Orchitis (HP:0100796)3.28425077
24* Encephalitis (HP:0002383)3.23449968
25Pustule (HP:0200039)3.13267193
26* Keratoconjunctivitis (HP:0001096)3.09761231
27Chest pain (HP:0100749)3.06220464
28Premature loss of primary teeth (HP:0006323)2.97897815
29Recurrent cutaneous fungal infections (HP:0011370)2.96583758
30Chronic mucocutaneous candidiasis (HP:0002728)2.96583758
31Recurrent viral infections (HP:0004429)2.95522310
32T lymphocytopenia (HP:0005403)2.88984765
33Recurrent pneumonia (HP:0006532)2.88939692
34Increased cerebral lipofuscin (HP:0011813)2.88697332
35Episodic fever (HP:0001954)2.88347944
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.85449739
37Abnormality of T cell number (HP:0011839)2.83604981
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81701690
39Basal ganglia calcification (HP:0002135)2.81343615
40Chronic otitis media (HP:0000389)2.79795331
41Vacuolated lymphocytes (HP:0001922)2.73052629
42* Gangrene (HP:0100758)2.70474844
43Urticaria (HP:0001025)2.69637202
44* Pulmonary infiltrates (HP:0002113)2.66189335
45Gastrointestinal inflammation (HP:0004386)2.65823406
46Increased IgM level (HP:0003496)2.63890180
47Colitis (HP:0002583)2.63775163
48Epistaxis (HP:0000421)2.60995729
49Peritonitis (HP:0002586)2.59543934
50Tetraparesis (HP:0002273)2.57161028
51Osteomyelitis (HP:0002754)2.55089447
52* Meningitis (HP:0001287)2.53860279
53Hypochromic microcytic anemia (HP:0004840)2.52288645
54Cellulitis (HP:0100658)2.50023960
55Leukocytosis (HP:0001974)2.47981751
56Hypochromic anemia (HP:0001931)2.46683092
57Petechiae (HP:0000967)2.46421346
58Albinism (HP:0001022)2.46032307
59Abnormality of T cells (HP:0002843)2.43936029
60Absent frontal sinuses (HP:0002688)2.42877789
61Pulmonary artery stenosis (HP:0004415)2.40017476
62Stomach cancer (HP:0012126)2.37584753
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37530618
64* Anorexia (HP:0002039)2.35088612
65* Pulmonary embolism (HP:0002204)2.34628325
66Lymphopenia (HP:0001888)2.33802229
67Recurrent lower respiratory tract infections (HP:0002783)2.32633604
68Panhypogammaglobulinemia (HP:0003139)2.32241322
69Chromsome breakage (HP:0040012)2.28354984
70* Abnormality of the pleura (HP:0002103)2.27876877
71Systemic lupus erythematosus (HP:0002725)2.27277748
72Abnormality of the peritoneum (HP:0002585)2.23958009
73Purpura (HP:0000979)2.23693230
74Increased serum ferritin (HP:0003281)2.22469109
75Cheilitis (HP:0100825)2.22378313
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.22184509
77Autoimmune hemolytic anemia (HP:0001890)2.21479071
78Increased IgE level (HP:0003212)2.20764113
79Bone pain (HP:0002653)2.19755843
80Abnormality of the prostate (HP:0008775)2.19681887
81Gingival bleeding (HP:0000225)2.18716372
82Submucous cleft hard palate (HP:0000176)2.17123376
83Dysostosis multiplex (HP:0000943)2.15594949
84Abnormality of T cell physiology (HP:0011840)2.14994907
85Eosinophilia (HP:0001880)2.14858964
86Abnormality of liposaccharide metabolism (HP:0010968)2.13338728
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.13338728
88Abnormality of glycolipid metabolism (HP:0010969)2.13338728
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.08817516
90Clubbing of toes (HP:0100760)2.07991760
91Agammaglobulinemia (HP:0004432)2.07695748
92Myocardial infarction (HP:0001658)2.06659328
93Abnormality of primary teeth (HP:0006481)2.05621637
94Parakeratosis (HP:0001036)2.02982736
95Amaurosis fugax (HP:0100576)2.02658862
96Interstitial pulmonary disease (HP:0006530)2.00267786
97* Vertigo (HP:0002321)1.98088902
98Porencephaly (HP:0002132)1.98079660
99Abnormality of iron homeostasis (HP:0011031)1.97272416
100Acute hepatic failure (HP:0006554)1.95425562
101Slow saccadic eye movements (HP:0000514)1.94757008
102* Abnormality of the endocardium (HP:0004306)1.93718497
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.91566605
104Osteolytic defects of the hand bones (HP:0009699)1.91566605
105* Polyneuropathy (HP:0001271)1.91452833
106Hepatosplenomegaly (HP:0001433)1.91353393
107Hypergammaglobulinemia (HP:0010702)1.90333484
108Alveolar cell carcinoma (HP:0006519)1.90306191
109Loss of speech (HP:0002371)1.88680883
110Abnormality of the nasal septum (HP:0000419)1.88267642
111* Skin ulcer (HP:0200042)1.87193018
112Emphysema (HP:0002097)1.86494082
113Gastrointestinal stroma tumor (HP:0100723)1.86418023
114Granulocytopenia (HP:0001913)1.84243858
115Sepsis (HP:0100806)1.83249293
116Leukopenia (HP:0001882)1.83242258
117Inflammation of the large intestine (HP:0002037)1.81655515
118Hematochezia (HP:0002573)1.81599757
119* Hemoptysis (HP:0002105)1.79431962
120Progressive visual loss (HP:0000529)1.77510880
121Amyloidosis (HP:0011034)1.76956046
122* Arterial thrombosis (HP:0004420)1.76311717
123IgM deficiency (HP:0002850)1.76122782
124Prolonged bleeding time (HP:0003010)1.75926326
125Plantar hyperkeratosis (HP:0007556)1.75492338
126Joint hemorrhage (HP:0005261)1.74680503
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73687082
128Recurrent bronchitis (HP:0002837)1.73084348
129Abnormality of the frontal sinuses (HP:0002687)1.73008019
130Aplasia cutis congenita (HP:0001057)1.72016602
131Axonal loss (HP:0003447)1.71027180
132Restrictive lung disease (HP:0002091)1.70740954
133Chronic sinusitis (HP:0011109)1.70434028
134Gastrointestinal infarctions (HP:0005244)1.69547221
135Disinhibition (HP:0000734)1.69430833
136* Arthralgia (HP:0002829)1.67699605
137* Keratoconjunctivitis sicca (HP:0001097)1.67052042
138Spinal cord lesions (HP:0100561)1.65492568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.88158512
2IRAK34.57702136
3IRAK43.56772258
4RIPK43.54916965
5IKBKE3.40850296
6TYK23.28965737
7TBK13.15055169
8TXK3.11327685
9JAK32.77368687
10IKBKB2.52609868
11MAP4K12.48942337
12BLK2.45917130
13KIT2.02907260
14JAK11.95272745
15CHUK1.90903622
16ZAK1.81475279
17SIK31.81134112
18EIF2AK21.66980906
19TAOK11.64450620
20GRK61.62882070
21MAP3K131.55060809
22FGR1.49982413
23CSK1.46018563
24YES11.37817378
25FGFR31.36691103
26MAP3K111.36321233
27HCK1.32428872
28BMPR21.32188177
29MAP3K31.27602497
30MAP3K11.24692094
31MARK31.24040313
32SYK1.17565297
33ERBB31.16692405
34TAOK21.14582476
35BTK1.14409698
36CSF1R1.10882250
37KSR21.06687105
38TEC1.05463297
39ERN11.05031265
40LYN1.01913519
41TRPM71.01178532
42PIM11.01076685
43FES1.00764118
44TAOK30.99612682
45TGFBR20.97481246
46LCK0.96547366
47CLK10.96103490
48ZAP700.95756610
49NUAK10.94492875
50CDC42BPA0.90974320
51STK240.86006206
52PDK10.82283101
53IRAK10.81968888
54EPHB10.81852272
55SIK20.80343768
56MARK20.79557374
57JAK20.78430143
58RPS6KA40.77399284
59MATK0.76821825
60MAP2K30.75075384
61PIM20.72945574
62FGFR40.72664380
63EPHA30.71412614
64PBK0.70316299
65MAP3K60.69984507
66PDPK10.69765209
67BMPR1B0.69592607
68CASK0.66055974
69SGK20.65615110
70MOS0.65413653
71IRAK20.65095575
72MAP3K50.64357894
73TRIB30.63476072
74STK100.62974632
75ABL10.62275421
76PRKCD0.61449472
77PRKD20.60698939
78RIPK10.59026654
79HIPK20.58028204
80TIE10.57128141
81FYN0.57079378
82MAPK120.55161810
83PIK3CG0.54365375
84SGK30.54172397
85ADRBK20.53355413
86PLK40.52222784
87MAP3K20.51982887
88LRRK20.51859910
89SMG10.51435742
90TNK20.50106180
91SIK10.48723472
92PRKCQ0.48352426
93STK30.48310369
94CDK190.47883810
95MAP3K70.47724486
96EGFR0.45171776
97RPS6KA60.43898668
98TESK20.42949836
99PRKG20.42812421
100CDK120.42722074
101ERBB40.42122437
102BMX0.41522931
103INSRR0.40421555
104PTK60.39382689
105MAPKAPK20.36653779
106PTK2B0.36411778
107RPS6KA20.36284574
108STK40.35735292
109ITK0.34997525
110RPS6KC10.34118210
111RPS6KL10.34118210
112DYRK1B0.33394099
113PRKAA20.32941374
114CDK60.32653395
115MAP2K60.31992088
116GRK70.31481271
117KSR10.31112984
118SGK10.30762647
119PKN10.29497562
120STK110.29177120
121RET0.29013164
122PRPF4B0.28675421
123RAF10.28209402
124BRD40.27952750
125DAPK20.27564995
126NLK0.26360457
127NEK90.26118180
128PLK20.25245990
129MAPK70.23356872
130MUSK0.22656645
131CDK80.21502574
132GRK10.21181990
133INSR0.19206339
134IGF1R0.18271995

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.18170353
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.92821418
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74916902
4Graft-versus-host disease_Homo sapiens_hsa053322.54266579
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.43147625
6Osteoclast differentiation_Homo sapiens_hsa043802.35946657
7Legionellosis_Homo sapiens_hsa051342.31714125
8* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31321536
9Malaria_Homo sapiens_hsa051442.30714975
10Measles_Homo sapiens_hsa051622.30447308
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.24945321
12Allograft rejection_Homo sapiens_hsa053302.19321302
13Staphylococcus aureus infection_Homo sapiens_hsa051502.09895015
14Influenza A_Homo sapiens_hsa051642.09132779
15* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07329615
16* TNF signaling pathway_Homo sapiens_hsa046682.07235928
17Rheumatoid arthritis_Homo sapiens_hsa053232.03627168
18* Tuberculosis_Homo sapiens_hsa051522.00442941
19Pertussis_Homo sapiens_hsa051331.98623375
20Hematopoietic cell lineage_Homo sapiens_hsa046401.86357730
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.82632453
22Asthma_Homo sapiens_hsa053101.81179184
23Herpes simplex infection_Homo sapiens_hsa051681.77179586
24B cell receptor signaling pathway_Homo sapiens_hsa046621.67231848
25African trypanosomiasis_Homo sapiens_hsa051431.63825073
26Toxoplasmosis_Homo sapiens_hsa051451.60021084
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45428154
28Apoptosis_Homo sapiens_hsa042101.44701491
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.40503326
30Salmonella infection_Homo sapiens_hsa051321.39349173
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36281840
32Hepatitis C_Homo sapiens_hsa051601.35650739
33Type I diabetes mellitus_Homo sapiens_hsa049401.35643138
34Phagosome_Homo sapiens_hsa041451.35068982
35Autoimmune thyroid disease_Homo sapiens_hsa053201.30172212
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28832930
37Chemokine signaling pathway_Homo sapiens_hsa040621.26394974
38Lysosome_Homo sapiens_hsa041421.20050700
39Primary immunodeficiency_Homo sapiens_hsa053401.19732439
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.19113392
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18112538
42Hepatitis B_Homo sapiens_hsa051611.17071836
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06598041
44* Shigellosis_Homo sapiens_hsa051311.04993577
45T cell receptor signaling pathway_Homo sapiens_hsa046600.99943146
46Other glycan degradation_Homo sapiens_hsa005110.99215004
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96434934
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94861660
49Non-small cell lung cancer_Homo sapiens_hsa052230.91815395
50Amoebiasis_Homo sapiens_hsa051460.90680541
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.87599360
52VEGF signaling pathway_Homo sapiens_hsa043700.84399229
53Notch signaling pathway_Homo sapiens_hsa043300.82999316
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82468657
55Viral myocarditis_Homo sapiens_hsa054160.80202568
56Acute myeloid leukemia_Homo sapiens_hsa052210.80149601
57Antigen processing and presentation_Homo sapiens_hsa046120.79162964
58Prolactin signaling pathway_Homo sapiens_hsa049170.74456734
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72389113
60Small cell lung cancer_Homo sapiens_hsa052220.71661079
61Renal cell carcinoma_Homo sapiens_hsa052110.70989404
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70221120
63Pancreatic cancer_Homo sapiens_hsa052120.67399555
64Epstein-Barr virus infection_Homo sapiens_hsa051690.67226170
65Sphingolipid metabolism_Homo sapiens_hsa006000.66327771
66Chronic myeloid leukemia_Homo sapiens_hsa052200.63948667
67Type II diabetes mellitus_Homo sapiens_hsa049300.62943790
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61386877
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60749575
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.59797880
71Endocytosis_Homo sapiens_hsa041440.57037022
72GnRH signaling pathway_Homo sapiens_hsa049120.56517662
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56429215
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56203752
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.54988506
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47901420
77Platelet activation_Homo sapiens_hsa046110.47443606
78p53 signaling pathway_Homo sapiens_hsa041150.47228005
79HTLV-I infection_Homo sapiens_hsa051660.46948424
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46030278
81MicroRNAs in cancer_Homo sapiens_hsa052060.45462669
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.45158293
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45057287
84Choline metabolism in cancer_Homo sapiens_hsa052310.44033935
85Endometrial cancer_Homo sapiens_hsa052130.43538225
86Caffeine metabolism_Homo sapiens_hsa002320.43490971
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42577917
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.42456977
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42018192
90Bladder cancer_Homo sapiens_hsa052190.41794578
91Viral carcinogenesis_Homo sapiens_hsa052030.41717993
92Inositol phosphate metabolism_Homo sapiens_hsa005620.40423169
93mTOR signaling pathway_Homo sapiens_hsa041500.35571196
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35550191
95Dorso-ventral axis formation_Homo sapiens_hsa043200.35523195
96HIF-1 signaling pathway_Homo sapiens_hsa040660.35015067
97Collecting duct acid secretion_Homo sapiens_hsa049660.35012083
98Proteoglycans in cancer_Homo sapiens_hsa052050.34964415
99FoxO signaling pathway_Homo sapiens_hsa040680.34727771
100Systemic lupus erythematosus_Homo sapiens_hsa053220.34142385
101Arachidonic acid metabolism_Homo sapiens_hsa005900.34106122
102ErbB signaling pathway_Homo sapiens_hsa040120.33313193
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33266544
104Colorectal cancer_Homo sapiens_hsa052100.32863298
105MAPK signaling pathway_Homo sapiens_hsa040100.31600436
106Vitamin digestion and absorption_Homo sapiens_hsa049770.31251103
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27096467
108Estrogen signaling pathway_Homo sapiens_hsa049150.26204468
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24709371
110Insulin resistance_Homo sapiens_hsa049310.22099947
111Adherens junction_Homo sapiens_hsa045200.21911205
112Mineral absorption_Homo sapiens_hsa049780.21445215
113Pathways in cancer_Homo sapiens_hsa052000.21116195
114ABC transporters_Homo sapiens_hsa020100.20794367
115Rap1 signaling pathway_Homo sapiens_hsa040150.19461492
116Prostate cancer_Homo sapiens_hsa052150.19004070

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