NODAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primitive streak formation (GO:0090009)7.98875512
2regulation of gene silencing by RNA (GO:0060966)6.45113233
3regulation of posttranscriptional gene silencing (GO:0060147)6.45113233
4regulation of gene silencing by miRNA (GO:0060964)6.45113233
5notochord development (GO:0030903)5.88419864
6somite rostral/caudal axis specification (GO:0032525)5.39382125
7negative regulation of activin receptor signaling pathway (GO:0032926)5.34818120
8regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.70849198
9nuclear pore organization (GO:0006999)4.69860888
10anterior/posterior axis specification (GO:0009948)4.65364511
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.58170992
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.58170992
13folic acid-containing compound biosynthetic process (GO:0009396)4.53379251
14DNA replication initiation (GO:0006270)4.52070330
15* regulation of mesoderm development (GO:2000380)4.50542116
16DNA replication-dependent nucleosome assembly (GO:0006335)4.47953581
17DNA replication-dependent nucleosome organization (GO:0034723)4.47953581
18formation of translation preinitiation complex (GO:0001731)4.46067158
19DNA unwinding involved in DNA replication (GO:0006268)4.38387404
20nuclear pore complex assembly (GO:0051292)4.34973433
21regulation of helicase activity (GO:0051095)4.33977125
22protein complex localization (GO:0031503)4.30316400
23* cell migration involved in gastrulation (GO:0042074)4.23148217
24protein localization to kinetochore (GO:0034501)4.20340341
25female gonad development (GO:0008585)4.17306801
26regulation of cell fate commitment (GO:0010453)4.16633779
27mitotic metaphase plate congression (GO:0007080)4.15344276
28nucleobase biosynthetic process (GO:0046112)4.07717908
29mitotic sister chromatid segregation (GO:0000070)4.06018212
30mitotic nuclear envelope disassembly (GO:0007077)4.04908647
31cell fate commitment involved in formation of primary germ layer (GO:0060795)4.04240926
32DNA strand elongation involved in DNA replication (GO:0006271)4.03861217
33anterior/posterior axis specification, embryo (GO:0008595)4.02219067
34IMP biosynthetic process (GO:0006188)3.98411415
35positive regulation of catenin import into nucleus (GO:0035413)3.97124352
36pre-miRNA processing (GO:0031054)3.96999888
37response to dietary excess (GO:0002021)3.96063956
38* regulation of activin receptor signaling pathway (GO:0032925)3.94776890
39embryonic axis specification (GO:0000578)3.93963284
40regulation of cell fate specification (GO:0042659)3.92606583
41regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.85693506
42histone H4-K12 acetylation (GO:0043983)3.83429842
43L-serine metabolic process (GO:0006563)3.83392699
44establishment of apical/basal cell polarity (GO:0035089)3.82410246
45ribosome biogenesis (GO:0042254)3.82306278
46DNA strand elongation (GO:0022616)3.82269072
47paraxial mesoderm development (GO:0048339)3.81198499
48cellular protein complex localization (GO:0034629)3.80812473
49maturation of SSU-rRNA (GO:0030490)3.80402147
50determination of adult lifespan (GO:0008340)3.80283888
51* positive regulation of SMAD protein import into nucleus (GO:0060391)3.78355110
52CENP-A containing nucleosome assembly (GO:0034080)3.78265207
53membrane disassembly (GO:0030397)3.75396566
54nuclear envelope disassembly (GO:0051081)3.75396566
55* nodal signaling pathway (GO:0038092)3.73609958
56signal transduction involved in regulation of gene expression (GO:0023019)3.72829871
57telomere maintenance via semi-conservative replication (GO:0032201)3.66450452
58histone arginine methylation (GO:0034969)3.64439499
59regulation of translational fidelity (GO:0006450)3.63460155
60negative regulation of cell fate commitment (GO:0010454)3.62563028
61DNA geometric change (GO:0032392)3.57190136
62ribosome assembly (GO:0042255)3.57127694
63DNA duplex unwinding (GO:0032508)3.56751886
64DNA replication checkpoint (GO:0000076)3.56537733
65purine nucleobase biosynthetic process (GO:0009113)3.56465682
66regulation of telomere maintenance via telomerase (GO:0032210)3.52923216
67regulation of gene silencing (GO:0060968)3.52443384
68metaphase plate congression (GO:0051310)3.51961358
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.51650118
70histone exchange (GO:0043486)3.51425550
71negative regulation of epidermal cell differentiation (GO:0045605)3.49802086
72ribonucleoprotein complex biogenesis (GO:0022613)3.49459958
73sister chromatid segregation (GO:0000819)3.47186990
74regulation of histone H3-K9 methylation (GO:0051570)3.43914360
75establishment of integrated proviral latency (GO:0075713)3.42022278
76protein localization to chromosome, centromeric region (GO:0071459)3.39335185
77IMP metabolic process (GO:0046040)3.37843296
78heterochromatin organization (GO:0070828)3.32269682
79ribosomal small subunit biogenesis (GO:0042274)3.31960957
80regulation of mitotic spindle organization (GO:0060236)3.30066367
81regulation of spindle organization (GO:0090224)3.28826419
82negative regulation of histone methylation (GO:0031061)3.28177911
83pore complex assembly (GO:0046931)3.25139940
84establishment of monopolar cell polarity (GO:0061162)3.24896774
85establishment or maintenance of monopolar cell polarity (GO:0061339)3.24896774
86positive regulation of chromosome segregation (GO:0051984)3.23885720
87DNA replication-independent nucleosome organization (GO:0034724)3.23651323
88DNA replication-independent nucleosome assembly (GO:0006336)3.23651323
89negative regulation of epidermis development (GO:0045683)3.22975782
90mitochondrial RNA metabolic process (GO:0000959)3.21776451
91transcription from mitochondrial promoter (GO:0006390)3.21084385
92dorsal/ventral axis specification (GO:0009950)3.20379864
93viral transcription (GO:0019083)3.20349710
94translational termination (GO:0006415)3.14563884
95spliceosomal tri-snRNP complex assembly (GO:0000244)3.14489003
96regulation of centrosome cycle (GO:0046605)3.14000906
97peptidyl-arginine omega-N-methylation (GO:0035247)3.13392955
98telomere maintenance via telomere lengthening (GO:0010833)3.13277115
99ribosomal large subunit biogenesis (GO:0042273)3.10093114
100telomere maintenance via recombination (GO:0000722)3.09787529
101spliceosomal snRNP assembly (GO:0000387)3.09459994
102rRNA processing (GO:0006364)3.07589230
103gastrulation (GO:0007369)3.06859264
104negative regulation of gene silencing (GO:0060969)3.05652032
105translational initiation (GO:0006413)3.04447811
106protein K6-linked ubiquitination (GO:0085020)3.04333784
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.02560682
108establishment of chromosome localization (GO:0051303)3.02185944
109mitotic recombination (GO:0006312)3.02149085
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01814855
111histone H4-K5 acetylation (GO:0043981)3.00070722
112histone H4-K8 acetylation (GO:0043982)3.00070722
113mitochondrial DNA metabolic process (GO:0032042)2.99221354
114proline biosynthetic process (GO:0006561)2.98750253
115regulation of hippo signaling (GO:0035330)2.98714718
116rRNA metabolic process (GO:0016072)2.96940354
117kinetochore assembly (GO:0051382)2.96324634
118ribosomal small subunit assembly (GO:0000028)2.95552172
119* embryonic pattern specification (GO:0009880)2.95423498
120negative regulation of chromosome segregation (GO:0051985)2.95421476
121kinetochore organization (GO:0051383)2.94414279
122establishment of viral latency (GO:0019043)2.94101480
123translational elongation (GO:0006414)2.93010090
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92927744
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92927744
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.92927744
127DNA deamination (GO:0045006)2.91129269
128single strand break repair (GO:0000012)2.90475794
129negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.89884206
130replication fork processing (GO:0031297)2.89235833
131apoptotic process involved in morphogenesis (GO:0060561)2.88503967
132polarized epithelial cell differentiation (GO:0030859)2.88158007
133pteridine-containing compound biosynthetic process (GO:0042559)2.87651456
134negative regulation of cell fate specification (GO:0009996)2.87228598
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87175643
136chromatin remodeling at centromere (GO:0031055)2.86621623
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86506087
138mitotic G1 DNA damage checkpoint (GO:0031571)2.85307577
139ventricular cardiac muscle cell development (GO:0055015)2.84506389
140pseudouridine synthesis (GO:0001522)2.83874238
141* regulation of gastrulation (GO:0010470)2.83184896
142regulation of chromatin silencing (GO:0031935)2.81356919
143regulation of centriole replication (GO:0046599)2.80213871
144blastocyst development (GO:0001824)2.79020574
145positive regulation of cardiac muscle cell proliferation (GO:0060045)2.77871994
146lung-associated mesenchyme development (GO:0060484)2.76459755
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.76125538
148cranial suture morphogenesis (GO:0060363)2.73953163
149axis specification (GO:0009798)2.72729353
150serine family amino acid biosynthetic process (GO:0009070)2.71918301
151rRNA modification (GO:0000154)2.71601070
152DNA double-strand break processing (GO:0000729)2.71404386
153proteasome assembly (GO:0043248)2.70606980
154activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.70505362
155endoderm development (GO:0007492)2.68912500
156L-alpha-amino acid transmembrane transport (GO:1902475)2.68264193
157mitotic G2/M transition checkpoint (GO:0044818)2.66694742
158regulation of cofactor metabolic process (GO:0051193)2.61306927
159regulation of coenzyme metabolic process (GO:0051196)2.61306927
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60420145
161rRNA methylation (GO:0031167)2.60420066
162DNA damage response, detection of DNA damage (GO:0042769)2.59777045
163ATP-dependent chromatin remodeling (GO:0043044)2.59300781
164viral mRNA export from host cell nucleus (GO:0046784)2.58434160
165negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58398518
166L-ascorbic acid metabolic process (GO:0019852)2.57076586
167regulation of cardioblast differentiation (GO:0051890)2.56693033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48385063
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.10862091
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.74190405
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.74190405
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.74190405
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.60429028
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.35381471
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.23190989
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.11204141
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06840567
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76044855
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73156627
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61895074
14* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.60399959
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58620161
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.55918358
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54050116
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.43999670
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24971590
20* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.24861943
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.17418935
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16897210
23* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16447424
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13920984
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13758398
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.09741837
27* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.09622786
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08997321
29SOX2_18555785_ChIP-Seq_MESCs_Mouse2.08711855
30* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07548643
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.07256618
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.97355966
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97025932
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94188367
35* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94009604
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93528862
37XRN2_22483619_ChIP-Seq_HELA_Human1.93453479
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88866912
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82999257
40* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76025941
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75838000
42* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.75452606
43* SMAD3_21741376_ChIP-Seq_HESCs_Human1.73129314
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72997341
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.68765327
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67784639
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.66489378
48* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66180500
49* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64571283
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62844344
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61178208
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59433450
53* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.56524206
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.56061051
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55305387
56* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.54796962
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53420555
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50536562
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.50045191
60* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49017949
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.48069173
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47149765
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.45288978
64* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.44756454
65* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.42518257
66TTF2_22483619_ChIP-Seq_HELA_Human1.42491602
67* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41353876
68EOMES_21245162_ChIP-Seq_HESCs_Human1.36575726
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.35784397
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.35433437
71VDR_23849224_ChIP-Seq_CD4+_Human1.33774885
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32166224
73* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.30651279
74AR_21909140_ChIP-Seq_LNCAP_Human1.29577871
75* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29124795
76DCP1A_22483619_ChIP-Seq_HELA_Human1.26993773
77GABP_19822575_ChIP-Seq_HepG2_Human1.25204976
78FOXP3_21729870_ChIP-Seq_TREG_Human1.23907958
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23268278
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.22706565
81* SMAD4_21741376_ChIP-Seq_HESCs_Human1.22546782
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18543362
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16297304
84* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15510052
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13468943
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.11964306
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11875093
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10727253
89KDM5A_27292631_Chip-Seq_BREAST_Human1.10453897
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.08992791
91* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08653625
92MYC_22102868_ChIP-Seq_BL_Human1.08637155
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08449309
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06499342
95* KAP1_27257070_Chip-Seq_ESCs_Mouse1.06269802
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04319786
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01119382
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01117049
99TFEB_21752829_ChIP-Seq_HELA_Human0.98613203
100ELK1_19687146_ChIP-ChIP_HELA_Human0.98206283
101HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97368877
102* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97191857
103* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96959364
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95512376
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94562443
106* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94104299
107CIITA_25753668_ChIP-Seq_RAJI_Human0.94088225
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.92664997
109* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90758048
110* NANOG_16153702_ChIP-ChIP_HESCs_Human0.90676899
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89426403
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88827986
113* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83721430
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83056162
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.82108953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.49779996
2MP0004957_abnormal_blastocyst_morpholog4.13882661
3MP0003111_abnormal_nucleus_morphology3.96883829
4MP0010094_abnormal_chromosome_stability3.93050551
5MP0003693_abnormal_embryo_hatching3.92184560
6MP0003077_abnormal_cell_cycle3.54453772
7MP0003806_abnormal_nucleotide_metabolis3.47252540
8* MP0004133_heterotaxia3.34165531
9MP0008058_abnormal_DNA_repair2.83366241
10MP0010352_gastrointestinal_tract_polyps2.79734149
11MP0002653_abnormal_ependyma_morphology2.71155664
12MP0003890_abnormal_embryonic-extraembry2.55959161
13MP0008932_abnormal_embryonic_tissue2.50349421
14MP0000350_abnormal_cell_proliferation2.36279645
15MP0003283_abnormal_digestive_organ2.29629823
16* MP0001730_embryonic_growth_arrest2.27840914
17MP0010030_abnormal_orbit_morphology2.25842136
18MP0003941_abnormal_skin_development2.25489311
19MP0005499_abnormal_olfactory_system2.25151308
20MP0008007_abnormal_cellular_replicative2.15116719
21MP0003123_paternal_imprinting2.08135698
22* MP0002084_abnormal_developmental_patter2.07298824
23MP0008004_abnormal_stomach_pH2.05321319
24* MP0002085_abnormal_embryonic_tissue2.03004136
25* MP0005380_embryogenesis_phenotype1.99545635
26* MP0001672_abnormal_embryogenesis/_devel1.99545635
27MP0004197_abnormal_fetal_growth/weight/1.93583433
28* MP0001697_abnormal_embryo_size1.90837715
29MP0003786_premature_aging1.82565710
30* MP0002086_abnormal_extraembryonic_tissu1.81333682
31MP0001293_anophthalmia1.78764171
32MP0003984_embryonic_growth_retardation1.69213687
33MP0002088_abnormal_embryonic_growth/wei1.66158039
34* MP0003119_abnormal_digestive_system1.65104507
35MP0010307_abnormal_tumor_latency1.65000469
36MP0003718_maternal_effect1.63601971
37* MP0002080_prenatal_lethality1.62846902
38MP0009672_abnormal_birth_weight1.61934198
39MP0006292_abnormal_olfactory_placode1.61145901
40MP0008877_abnormal_DNA_methylation1.56922148
41MP0003136_yellow_coat_color1.54257610
42MP0004264_abnormal_extraembryonic_tissu1.54140275
43MP0002163_abnormal_gland_morphology1.53536875
44MP0000462_abnormal_digestive_system1.49459945
45MP0005076_abnormal_cell_differentiation1.44748762
46MP0005266_abnormal_metabolism1.35590045
47MP0003705_abnormal_hypodermis_morpholog1.33756497
48MP0008789_abnormal_olfactory_epithelium1.32744538
49MP0002111_abnormal_tail_morphology1.31756332
50MP0004272_abnormal_basement_membrane1.26997294
51MP0000678_abnormal_parathyroid_gland1.26949054
52MP0000313_abnormal_cell_death1.26336445
53MP0002254_reproductive_system_inflammat1.25373422
54MP0009053_abnormal_anal_canal1.21877869
55MP0002233_abnormal_nose_morphology1.20835376
56MP0003121_genomic_imprinting1.18791990
57MP0003385_abnormal_body_wall1.18614614
58MP0003566_abnormal_cell_adhesion1.17186356
59MP0002736_abnormal_nociception_after1.14371601
60MP0001849_ear_inflammation1.12409657
61MP0002160_abnormal_reproductive_system1.10108260
62MP0000490_abnormal_crypts_of1.10059835
63MP0002332_abnormal_exercise_endurance1.10047907
64MP0003137_abnormal_impulse_conducting1.08223555
65MP0006054_spinal_hemorrhage1.07850788
66MP0005501_abnormal_skin_physiology1.06913915
67* MP0000428_abnormal_craniofacial_morphol1.05656182
68MP0000537_abnormal_urethra_morphology1.05635251
69MP0002796_impaired_skin_barrier1.04838957
70MP0001145_abnormal_male_reproductive1.04040139
71MP0006035_abnormal_mitochondrial_morpho1.03901680
72MP0002019_abnormal_tumor_incidence1.03435245
73MP0002249_abnormal_larynx_morphology1.02879592
74MP0003567_abnormal_fetal_cardiomyocyte1.00784228
75MP0000516_abnormal_urinary_system1.00719591
76MP0005367_renal/urinary_system_phenotyp1.00719591
77MP0003937_abnormal_limbs/digits/tail_de0.99734796
78MP0002210_abnormal_sex_determination0.99615830
79MP0010234_abnormal_vibrissa_follicle0.99492669
80MP0002127_abnormal_cardiovascular_syste0.96985783
81MP0000432_abnormal_head_morphology0.93992823
82MP0003646_muscle_fatigue0.93466669
83MP0001661_extended_life_span0.92997848
84MP0009384_cardiac_valve_regurgitation0.92035255
85MP0005023_abnormal_wound_healing0.90821976
86* MP0003861_abnormal_nervous_system0.88695423
87MP0002697_abnormal_eye_size0.87437797
88MP0000762_abnormal_tongue_morphology0.86954621
89MP0003315_abnormal_perineum_morphology0.86567827
90MP0005389_reproductive_system_phenotype0.85715828
91* MP0001286_abnormal_eye_development0.84796362
92MP0004858_abnormal_nervous_system0.84784990
93MP0008961_abnormal_basal_metabolism0.83782210
94MP0005379_endocrine/exocrine_gland_phen0.82386196
95MP0003936_abnormal_reproductive_system0.80780794
96MP0004185_abnormal_adipocyte_glucose0.79427170
97MP0002092_abnormal_eye_morphology0.78955252
98MP0002269_muscular_atrophy0.76621471
99MP0000653_abnormal_sex_gland0.75524848
100MP0002751_abnormal_autonomic_nervous0.74398188
101MP0001929_abnormal_gametogenesis0.74025049
102MP0003186_abnormal_redox_activity0.73900164
103MP0003195_calcinosis0.73645040
104MP0005384_cellular_phenotype0.71605803
105MP0000358_abnormal_cell_content/0.71324541
106MP0009703_decreased_birth_body0.70986946
107MP0004233_abnormal_muscle_weight0.70840973
108MP0001915_intracranial_hemorrhage0.70598917
109MP0003755_abnormal_palate_morphology0.70580430
110MP0002938_white_spotting0.68260465
111MP0000750_abnormal_muscle_regeneration0.67858069
112MP0008770_decreased_survivor_rate0.67771085
113MP0005621_abnormal_cell_physiology0.67417635
114MP0006072_abnormal_retinal_apoptosis0.66916794
115MP0005257_abnormal_intraocular_pressure0.66884626
116MP0000049_abnormal_middle_ear0.66047428
117MP0002114_abnormal_axial_skeleton0.65518527
118MP0000477_abnormal_intestine_morphology0.65415809
119* MP0002925_abnormal_cardiovascular_devel0.65148720
120* MP0003935_abnormal_craniofacial_develop0.63004437
121MP0003453_abnormal_keratinocyte_physiol0.62215366
122MP0000467_abnormal_esophagus_morphology0.61658401
123MP0003221_abnormal_cardiomyocyte_apopto0.60167396
124MP0003878_abnormal_ear_physiology0.60028907
125MP0005377_hearing/vestibular/ear_phenot0.60028907
126MP0002102_abnormal_ear_morphology0.56585054
127MP0005394_taste/olfaction_phenotype0.56484498
128MP0009697_abnormal_copulation0.56033347
129MP0005197_abnormal_uvea_morphology0.52887361
130MP0003699_abnormal_female_reproductive0.51256756
131MP0002090_abnormal_vision0.51168363

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.55897741
2Bilateral microphthalmos (HP:0007633)4.48609383
3Abnormality of the labia minora (HP:0012880)4.44527587
4Supernumerary spleens (HP:0009799)4.22411727
5Absent radius (HP:0003974)4.06509085
6Astrocytoma (HP:0009592)3.96373243
7Abnormality of the astrocytes (HP:0100707)3.96373243
8Medulloblastoma (HP:0002885)3.92740545
9Rib fusion (HP:0000902)3.89680021
10Absent forearm bone (HP:0003953)3.82201153
11Aplasia involving forearm bones (HP:0009822)3.82201153
12Breast hypoplasia (HP:0003187)3.74469066
13Aplasia/hypoplasia of the humerus (HP:0006507)3.72732953
14Neoplasm of the oral cavity (HP:0100649)3.67063812
15Birth length less than 3rd percentile (HP:0003561)3.63806931
16Agnosia (HP:0010524)3.51801607
17Short humerus (HP:0005792)3.49361522
18Selective tooth agenesis (HP:0001592)3.46390134
19Colon cancer (HP:0003003)3.45532796
20Rhabdomyosarcoma (HP:0002859)3.42791929
21Congenital malformation of the right heart (HP:0011723)3.42103103
22Double outlet right ventricle (HP:0001719)3.42103103
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35492702
24Abnormal umbilical cord blood vessels (HP:0011403)3.26527247
25Single umbilical artery (HP:0001195)3.26527247
26Abnormality of the fetal cardiovascular system (HP:0010948)3.26527247
27Hypoplasia of the fovea (HP:0007750)3.25380952
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.25380952
29Glioma (HP:0009733)3.23140269
30Chromsome breakage (HP:0040012)3.21929570
31Reticulocytopenia (HP:0001896)3.14501447
32Missing ribs (HP:0000921)3.09305056
33Absent thumb (HP:0009777)3.03757309
34Hepatoblastoma (HP:0002884)3.02978631
35Neoplasm of striated muscle (HP:0009728)3.02389850
36Basal cell carcinoma (HP:0002671)2.99635821
37Patellar aplasia (HP:0006443)2.99103570
38Rectal fistula (HP:0100590)2.95799951
39Rectovaginal fistula (HP:0000143)2.95799951
40Abnormality of the salivary glands (HP:0010286)2.95658041
41Asplenia (HP:0001746)2.93955101
42Oligodactyly (hands) (HP:0001180)2.82889405
43Abnormality of the fovea (HP:0000493)2.72838569
44Bifid tongue (HP:0010297)2.71512861
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.70993070
46Abnormal number of incisors (HP:0011064)2.69955618
47Aplasia/Hypoplasia of the patella (HP:0006498)2.69033406
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.66897723
49Shawl scrotum (HP:0000049)2.66706355
50Esophageal atresia (HP:0002032)2.65302064
51Oral leukoplakia (HP:0002745)2.64961680
52Trismus (HP:0000211)2.62743213
53Carpal bone hypoplasia (HP:0001498)2.60923501
54Hypoplastic female external genitalia (HP:0012815)2.57854292
55Abnormality of the ileum (HP:0001549)2.55515098
56Impulsivity (HP:0100710)2.55378001
57Labial hypoplasia (HP:0000066)2.54775686
58Ectopic anus (HP:0004397)2.54532567
59Intestinal fistula (HP:0100819)2.53459168
60Abnormality of the parathyroid morphology (HP:0011766)2.53076963
61Aqueductal stenosis (HP:0002410)2.52726533
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.50091435
63Aplasia/Hypoplasia of the macula (HP:0008059)2.49792168
64Short middle phalanx of the 5th finger (HP:0004220)2.48563172
65Meckel diverticulum (HP:0002245)2.47912835
66Stenosis of the external auditory canal (HP:0000402)2.47598478
67Short hallux (HP:0010109)2.45677315
68Abnormality of the lower motor neuron (HP:0002366)2.45354489
69Vaginal fistula (HP:0004320)2.44153114
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.43005868
71Abnormality of pyrimidine metabolism (HP:0004353)2.38023953
72Breast aplasia (HP:0100783)2.37384689
73Hyperglycinuria (HP:0003108)2.36650724
74Progressive inability to walk (HP:0002505)2.36188490
75Myelomeningocele (HP:0002475)2.35700278
76Aplasia/Hypoplasia affecting the retina (HP:0008061)2.34807395
77Vertebral fusion (HP:0002948)2.30272243
78Preaxial foot polydactyly (HP:0001841)2.30142775
79Abnormality of the umbilical cord (HP:0010881)2.29111529
80Squamous cell carcinoma (HP:0002860)2.28087807
81Anophthalmia (HP:0000528)2.27885854
82Cerebral hypomyelination (HP:0006808)2.27838016
83Duplicated collecting system (HP:0000081)2.26975113
84Aplasia/Hypoplasia of the hallux (HP:0008362)2.25671741
85Fused cervical vertebrae (HP:0002949)2.25131588
86Supernumerary bones of the axial skeleton (HP:0009144)2.23254995
87Anal stenosis (HP:0002025)2.20855222
88Rough bone trabeculation (HP:0100670)2.18638611
89Chin dimple (HP:0010751)2.18406744
90Supernumerary ribs (HP:0005815)2.18351047
91Tracheoesophageal fistula (HP:0002575)2.17770441
92Neoplasm of the pancreas (HP:0002894)2.17292419
93Abnormality of the preputium (HP:0100587)2.15942125
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15430119
95Abnormality of the septum pellucidum (HP:0007375)2.14521466
96Premature ovarian failure (HP:0008209)2.14465472
97Hemivertebrae (HP:0002937)2.13153033
98Abnormality of chromosome stability (HP:0003220)2.12792002
99Aplasia/Hypoplasia of the breasts (HP:0010311)2.12279310
100Multiple enchondromatosis (HP:0005701)2.10079563
101Vertebral clefting (HP:0008428)2.09690569
102Hyperglycinemia (HP:0002154)2.08974801
103Cortical dysplasia (HP:0002539)2.08928916
104Gastrointestinal atresia (HP:0002589)2.08860446
105Absent septum pellucidum (HP:0001331)2.08498614
106Mixed hearing impairment (HP:0000410)2.08297184
107Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.07645544
108Abnormal lung lobation (HP:0002101)2.07225910
109Anal atresia (HP:0002023)2.07085650
110Oligodactyly (HP:0012165)2.06389897
111Abnormal pancreas size (HP:0012094)2.06384534
11211 pairs of ribs (HP:0000878)2.04862518
113Adenoma sebaceum (HP:0009720)2.04745699
114Angiofibromas (HP:0010615)2.04745699
115Aplasia/Hypoplasia of the sternum (HP:0006714)2.03668336
116Septo-optic dysplasia (HP:0100842)2.03518493
117Biliary tract neoplasm (HP:0100574)2.02440675
118Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02402677
119Vertebral hypoplasia (HP:0008417)2.02402677
120* Abnormality of abdominal situs (HP:0011620)2.01708619
121* Abdominal situs inversus (HP:0003363)2.01708619
122Premature graying of hair (HP:0002216)1.97683485
123Proximal placement of thumb (HP:0009623)1.96017614
124Maternal diabetes (HP:0009800)1.95760778
125Horseshoe kidney (HP:0000085)1.95415548
126Hypoplastic pelvis (HP:0008839)1.94537397
127Abnormality of serine family amino acid metabolism (HP:0010894)1.93839069
128Abnormality of glycine metabolism (HP:0010895)1.93839069
129Deviation of the thumb (HP:0009603)1.92950467
130Nephroblastoma (Wilms tumor) (HP:0002667)1.91090559
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90505889
132Triphalangeal thumb (HP:0001199)1.90385930
133Pseudobulbar signs (HP:0002200)1.89855096
134Amaurosis fugax (HP:0100576)1.89563425
135Renal agenesis (HP:0000104)1.88330865
136Abnormality of cells of the erythroid lineage (HP:0012130)1.88098305
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87764473
138Nuclear cataract (HP:0100018)1.87306216
139Intestinal atresia (HP:0011100)1.87246124
140Facial hemangioma (HP:0000329)1.87027295
141Amelogenesis imperfecta (HP:0000705)1.86708065
142Duodenal stenosis (HP:0100867)1.85644169
143Small intestinal stenosis (HP:0012848)1.85644169
144Microvesicular hepatic steatosis (HP:0001414)1.85422519
145Facial cleft (HP:0002006)1.85318387
146Hypochromic microcytic anemia (HP:0004840)1.85164310
147Abnormality of the renal collecting system (HP:0004742)1.84868063
148Sloping forehead (HP:0000340)1.84829441
149Malignant gastrointestinal tract tumors (HP:0006749)1.84695846
150Gastrointestinal carcinoma (HP:0002672)1.84695846
151Metaphyseal cupping (HP:0003021)1.84136729
152Cleft eyelid (HP:0000625)1.83618896
153Embryonal renal neoplasm (HP:0011794)1.83488522
154Anencephaly (HP:0002323)1.82806812
155Absent toe (HP:0010760)1.80479369
156Cupped ear (HP:0000378)1.80442913
157Renal hypoplasia (HP:0000089)1.80240915
158Choanal stenosis (HP:0000452)1.80096259
159Gonadotropin excess (HP:0000837)1.79993433
160Spastic diplegia (HP:0001264)1.79514081
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77817628
162Abnormality of the labia (HP:0000058)1.77704693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.67595963
2BUB14.41622225
3CDK124.25745117
4WEE13.60631409
5CDC73.29271332
6TTK2.88987613
7RPS6KB22.74064866
8TAF12.73543718
9NEK12.55451521
10CDK72.39468660
11NEK22.21215313
12LMTK22.21124198
13AKT32.15836522
14PLK12.14277141
15VRK22.13057623
16TRIM282.07269648
17TSSK62.07195434
18STK161.87427407
19SRPK11.84892264
20TLK11.78666054
21TESK21.69214861
22SMG11.66471121
23CHEK21.66205408
24MAPKAPK31.56837632
25PAK41.56527787
26ICK1.55861538
27ATR1.54420933
28BRD41.46624566
29AURKB1.42258089
30AURKA1.42163860
31NME11.41368997
32PASK1.37577756
33CHEK11.37236532
34TNIK1.37133657
35BMPR1B1.35210410
36EIF2AK11.35008146
37LATS21.33219557
38STK101.29856099
39MAP3K81.28481121
40WNK31.27360608
41DYRK31.24292356
42CDK191.22244285
43PLK31.22095679
44VRK11.21898044
45ALK1.21607180
46SCYL21.15878747
47PNCK1.14995896
48PLK41.12945885
49TYRO31.10728724
50CDK41.06395477
51CDK21.02709014
52PRKCI1.00052613
53ATM0.99953249
54STK40.98537287
55PHKG10.96188913
56PHKG20.96188913
57PIM10.89497697
58MET0.89160541
59MATK0.88506279
60FLT30.86229691
61MAP3K110.85868910
62OXSR10.84948622
63MTOR0.84292672
64DDR20.83471071
65CDK60.83282081
66ACVR1B0.82836549
67STK38L0.81339421
68STK30.81025558
69DYRK20.79145635
70CSNK2A20.78387093
71ZAK0.78385425
72DAPK10.77789301
73NUAK10.76691686
74CSNK1E0.74053643
75NTRK10.72667593
76BRSK20.72027207
77CDK10.70337337
78AKT20.68948594
79BCKDK0.65413100
80NME20.65294091
81MAP2K20.64581331
82PAK10.64473449
83BMX0.63242307
84YES10.62313725
85TGFBR10.58661464
86GRK60.57724131
87EIF2AK30.57254746
88CSNK1D0.56742383
89CSNK2A10.56721902
90NLK0.56255312
91MKNK10.55854776
92PBK0.55294670
93PRKG20.53659967
94PDK20.53020883
95MAP3K120.50660515
96ERBB40.49520162
97MAP3K90.49240120
98PRKDC0.48250989
99STK240.48143622
100KDR0.46812452
101TESK10.46700899
102MKNK20.46482334
103MAP3K100.46317562
104DAPK30.45931624
105CSNK1G10.44980673
106FGFR20.44928519
107MAP3K60.44690764
108LATS10.44164234
109PRKD30.44147393
110GRK10.43277553
111MELK0.42780514
112EEF2K0.41848234
113MST40.39957963
114MAPK140.38336979
115MAPK10.37855375
116FGFR10.37729656
117PDK40.37702633
118PDK30.37702633
119PLK20.35488647
120GSK3B0.35480102
121DMPK0.35191516
122EIF2AK20.34775855
123FGR0.34464664
124TAOK20.33591539
125RPS6KA50.33046172
126MAP3K30.33003299
127CSNK1G20.31977516
128BRSK10.31872340
129BRAF0.31711419
130CAMK1D0.31276527
131AKT10.30569597
132BCR0.30344525
133PINK10.28471548
134SIK30.27003210
135STK390.25196945
136RPS6KA40.24187568
137CAMK1G0.19475093

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.87203669
2DNA replication_Homo sapiens_hsa030304.59542079
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08804081
4One carbon pool by folate_Homo sapiens_hsa006703.39749997
5Spliceosome_Homo sapiens_hsa030403.34794185
6RNA transport_Homo sapiens_hsa030133.26975782
7Ribosome_Homo sapiens_hsa030103.24616456
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00076381
9RNA polymerase_Homo sapiens_hsa030202.89426917
10Base excision repair_Homo sapiens_hsa034102.78047395
11Nucleotide excision repair_Homo sapiens_hsa034202.75581224
12Homologous recombination_Homo sapiens_hsa034402.72805150
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.43501978
14Fanconi anemia pathway_Homo sapiens_hsa034602.42387105
15Cell cycle_Homo sapiens_hsa041102.36929607
16Steroid biosynthesis_Homo sapiens_hsa001002.15176645
17Proteasome_Homo sapiens_hsa030502.05885678
18p53 signaling pathway_Homo sapiens_hsa041152.01622199
19Pyrimidine metabolism_Homo sapiens_hsa002401.97114181
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91262661
21mRNA surveillance pathway_Homo sapiens_hsa030151.88254636
22Non-homologous end-joining_Homo sapiens_hsa034501.81578925
23RNA degradation_Homo sapiens_hsa030181.72108099
24Biosynthesis of amino acids_Homo sapiens_hsa012301.64685415
25Basal cell carcinoma_Homo sapiens_hsa052171.59920171
26Basal transcription factors_Homo sapiens_hsa030221.52516797
27Hedgehog signaling pathway_Homo sapiens_hsa043401.43957507
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42338886
29Systemic lupus erythematosus_Homo sapiens_hsa053221.30242480
30* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28178256
31Hippo signaling pathway_Homo sapiens_hsa043901.23534916
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.19872166
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18574364
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.14695697
35Selenocompound metabolism_Homo sapiens_hsa004501.11379953
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08801103
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06705938
38Folate biosynthesis_Homo sapiens_hsa007901.03038886
39Propanoate metabolism_Homo sapiens_hsa006400.96592343
40Oocyte meiosis_Homo sapiens_hsa041140.95397694
41Protein export_Homo sapiens_hsa030600.92024498
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91901590
43Purine metabolism_Homo sapiens_hsa002300.91096813
44Fructose and mannose metabolism_Homo sapiens_hsa000510.89717064
45Vitamin digestion and absorption_Homo sapiens_hsa049770.88114681
46Viral carcinogenesis_Homo sapiens_hsa052030.84382643
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83247903
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81557391
49Epstein-Barr virus infection_Homo sapiens_hsa051690.81119357
50Parkinsons disease_Homo sapiens_hsa050120.79851573
51Fatty acid elongation_Homo sapiens_hsa000620.77054855
52Notch signaling pathway_Homo sapiens_hsa043300.75668626
53MicroRNAs in cancer_Homo sapiens_hsa052060.75031602
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74977095
55Carbon metabolism_Homo sapiens_hsa012000.73806609
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73201240
57Phototransduction_Homo sapiens_hsa047440.67215285
58N-Glycan biosynthesis_Homo sapiens_hsa005100.66731875
59Bladder cancer_Homo sapiens_hsa052190.66429173
60beta-Alanine metabolism_Homo sapiens_hsa004100.65777466
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63331850
62Sulfur relay system_Homo sapiens_hsa041220.63249790
63HTLV-I infection_Homo sapiens_hsa051660.62052953
64Thyroid cancer_Homo sapiens_hsa052160.61455582
65* TGF-beta signaling pathway_Homo sapiens_hsa043500.61336093
66Glutathione metabolism_Homo sapiens_hsa004800.60722584
67Tight junction_Homo sapiens_hsa045300.60357320
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60194579
69Arginine and proline metabolism_Homo sapiens_hsa003300.58742581
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.58221319
71Wnt signaling pathway_Homo sapiens_hsa043100.55979694
72mTOR signaling pathway_Homo sapiens_hsa041500.54721592
73Oxidative phosphorylation_Homo sapiens_hsa001900.53711053
74Adherens junction_Homo sapiens_hsa045200.53190258
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52549750
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.51577313
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47971965
78Alcoholism_Homo sapiens_hsa050340.46802469
79Pentose phosphate pathway_Homo sapiens_hsa000300.46483809
80Huntingtons disease_Homo sapiens_hsa050160.46194227
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45874622
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45836280
83Melanoma_Homo sapiens_hsa052180.44538737
84Pathways in cancer_Homo sapiens_hsa052000.44538111
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44065430
86Galactose metabolism_Homo sapiens_hsa000520.42410803
87Fatty acid metabolism_Homo sapiens_hsa012120.39742836
88Herpes simplex infection_Homo sapiens_hsa051680.39514142
89Fat digestion and absorption_Homo sapiens_hsa049750.37604022
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37247578
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36651165
92Colorectal cancer_Homo sapiens_hsa052100.34526852
93Lysine degradation_Homo sapiens_hsa003100.34177120
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33087077
95Fatty acid degradation_Homo sapiens_hsa000710.32506353
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30626868
97Small cell lung cancer_Homo sapiens_hsa052220.30554577
98Glucagon signaling pathway_Homo sapiens_hsa049220.28729492
99Arginine biosynthesis_Homo sapiens_hsa002200.28215571
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28173622
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26425963
102Nitrogen metabolism_Homo sapiens_hsa009100.25125629
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22983122
104HIF-1 signaling pathway_Homo sapiens_hsa040660.22737916
105Vitamin B6 metabolism_Homo sapiens_hsa007500.21912396
106Peroxisome_Homo sapiens_hsa041460.21869919
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21046947
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20441045
109Linoleic acid metabolism_Homo sapiens_hsa005910.20140151
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17868459
111Metabolic pathways_Homo sapiens_hsa011000.17651597
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17598231
113Apoptosis_Homo sapiens_hsa042100.17062272
114Antigen processing and presentation_Homo sapiens_hsa046120.16738753
115Starch and sucrose metabolism_Homo sapiens_hsa005000.15679082
116Proteoglycans in cancer_Homo sapiens_hsa052050.14697751
117Arachidonic acid metabolism_Homo sapiens_hsa005900.14673833
118Melanogenesis_Homo sapiens_hsa049160.14101920
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13972636
120Pyruvate metabolism_Homo sapiens_hsa006200.13428625
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13397449
122Fatty acid biosynthesis_Homo sapiens_hsa000610.13104455
123Legionellosis_Homo sapiens_hsa051340.09772698
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08501837
125Phenylalanine metabolism_Homo sapiens_hsa003600.08347268
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08170309
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05918692
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05706443
129Prion diseases_Homo sapiens_hsa050200.04259025
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02877065

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