NOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90125871
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81867278
3behavioral response to nicotine (GO:0035095)4.78309855
4locomotory exploration behavior (GO:0035641)4.78204323
5synaptic vesicle maturation (GO:0016188)4.68674672
6postsynaptic membrane organization (GO:0001941)4.62021518
7presynaptic membrane assembly (GO:0097105)4.38543549
8water-soluble vitamin biosynthetic process (GO:0042364)4.28704331
9neuron cell-cell adhesion (GO:0007158)4.22616045
10cell proliferation in forebrain (GO:0021846)4.19190710
11cartilage condensation (GO:0001502)4.14725233
12cell aggregation (GO:0098743)4.14725233
13protein localization to synapse (GO:0035418)4.13782224
14regulation of mesoderm development (GO:2000380)4.10867379
15regulation of glutamate receptor signaling pathway (GO:1900449)3.93104597
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.92749964
17NADH dehydrogenase complex assembly (GO:0010257)3.92749964
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92749964
19sulfation (GO:0051923)3.90117469
20limb bud formation (GO:0060174)3.84951587
21protein complex biogenesis (GO:0070271)3.81734886
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.79904449
23layer formation in cerebral cortex (GO:0021819)3.72781616
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71387518
25cellular response to ATP (GO:0071318)3.69907589
26chondrocyte development (GO:0002063)3.67679633
27protein polyglutamylation (GO:0018095)3.65730930
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63896071
29preassembly of GPI anchor in ER membrane (GO:0016254)3.60123168
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58251311
31presynaptic membrane organization (GO:0097090)3.56516918
32chondroitin sulfate catabolic process (GO:0030207)3.54899347
33exploration behavior (GO:0035640)3.48893806
34mitochondrial respiratory chain complex assembly (GO:0033108)3.40961558
35positive regulation of synapse assembly (GO:0051965)3.40583998
36* negative regulation of astrocyte differentiation (GO:0048712)3.39105434
37positive regulation of oligodendrocyte differentiation (GO:0048714)3.37803827
38short-term memory (GO:0007614)3.37778646
39synaptic vesicle exocytosis (GO:0016079)3.36572503
40notochord development (GO:0030903)3.35458393
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33191482
42GPI anchor metabolic process (GO:0006505)3.31130965
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30477344
44dermatan sulfate metabolic process (GO:0030205)3.29806878
45response to pheromone (GO:0019236)3.29310983
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.28096363
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.28096363
48ovulation cycle (GO:0042698)3.26073874
49vocalization behavior (GO:0071625)3.24620252
50indolalkylamine metabolic process (GO:0006586)3.20515200
51indole-containing compound catabolic process (GO:0042436)3.20213869
52indolalkylamine catabolic process (GO:0046218)3.20213869
53tryptophan catabolic process (GO:0006569)3.20213869
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.19754186
55* lateral sprouting from an epithelium (GO:0060601)3.19260845
56piRNA metabolic process (GO:0034587)3.18883470
57positive regulation of neurological system process (GO:0031646)3.18596750
58positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.18276537
59neuron recognition (GO:0008038)3.15073436
60positive regulation of male gonad development (GO:2000020)3.14184193
61dendritic spine morphogenesis (GO:0060997)3.14157185
62response to gravity (GO:0009629)3.09683391
63kynurenine metabolic process (GO:0070189)3.07750675
64negative regulation of mast cell activation (GO:0033004)3.03669049
65gamma-aminobutyric acid transport (GO:0015812)3.03626301
66negative regulation of transcription regulatory region DNA binding (GO:2000678)3.03241691
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.02920221
68axonal fasciculation (GO:0007413)3.02399322
69negative regulation of telomere maintenance (GO:0032205)3.01247464
70prostate gland growth (GO:0060736)2.99577623
71cornea development in camera-type eye (GO:0061303)2.99487833
72neurotransmitter-gated ion channel clustering (GO:0072578)2.99485165
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99362676
74peripheral nervous system axon ensheathment (GO:0032292)2.97789948
75myelination in peripheral nervous system (GO:0022011)2.97789948
76fucose catabolic process (GO:0019317)2.97054127
77L-fucose metabolic process (GO:0042354)2.97054127
78L-fucose catabolic process (GO:0042355)2.97054127
79mannosylation (GO:0097502)2.96454208
80dentate gyrus development (GO:0021542)2.96434914
81aggressive behavior (GO:0002118)2.95512972
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94523695
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.94187912
84parturition (GO:0007567)2.91737883
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.90749325
86purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.90749325
87retinal ganglion cell axon guidance (GO:0031290)2.89059907
88regulation of collateral sprouting (GO:0048670)2.88355516
89positive regulation of fatty acid transport (GO:2000193)2.86587672
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85442783
91dermatan sulfate biosynthetic process (GO:0030208)2.85269716
92positive regulation of cardiac muscle cell differentiation (GO:2000727)2.83283423
93chondrocyte differentiation (GO:0002062)2.83109648
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82790602
95cell communication by electrical coupling (GO:0010644)2.81532508
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.81520434
97pharyngeal system development (GO:0060037)2.81135123
98regulation of male gonad development (GO:2000018)2.77084163
99skin morphogenesis (GO:0043589)2.76798299
100adaptation of signaling pathway (GO:0023058)2.75793316
101rRNA catabolic process (GO:0016075)2.75517960
102tryptophan metabolic process (GO:0006568)2.75054160
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74998497
104regulation of hippo signaling (GO:0035330)2.74106270
105platelet dense granule organization (GO:0060155)2.74026708
106heart valve formation (GO:0003188)2.72857677
107neuronal action potential propagation (GO:0019227)2.72741730
108negative regulation of myoblast differentiation (GO:0045662)2.70161139
109endocardial cushion morphogenesis (GO:0003203)2.69972324
110DNA methylation involved in gamete generation (GO:0043046)2.68389768
111glutamate secretion (GO:0014047)2.67748803
112cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67215332
113regulation of long-term neuronal synaptic plasticity (GO:0048169)2.66227029
114positive regulation of fibroblast migration (GO:0010763)2.66119946
115positive regulation of defense response to virus by host (GO:0002230)2.66081209
116indole-containing compound metabolic process (GO:0042430)2.65980365
117chondroitin sulfate metabolic process (GO:0030204)2.65866432
118regulation of synapse assembly (GO:0051963)2.65737718
119positive regulation of mitochondrial fission (GO:0090141)2.65594542
120negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.64879217
121regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64841168
122regulation of action potential (GO:0098900)2.63620503
123interferon-gamma secretion (GO:0072643)2.63410435
124regulation of synaptic vesicle exocytosis (GO:2000300)2.62706159
125mesodermal cell differentiation (GO:0048333)2.62520115
126epithelial cilium movement (GO:0003351)2.62030658
127negative regulation of catenin import into nucleus (GO:0035414)2.61389860
128neurotransmitter secretion (GO:0007269)2.60927639
129negative regulation of systemic arterial blood pressure (GO:0003085)2.59975083
130axoneme assembly (GO:0035082)2.59238359
131membrane assembly (GO:0071709)2.58972924
132* regulation of astrocyte differentiation (GO:0048710)2.58250738
133negative regulation of T cell differentiation in thymus (GO:0033085)2.57979121
134regulation of sequestering of triglyceride (GO:0010889)2.56800897
135head development (GO:0060322)2.56454609
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56052130
137cytidine metabolic process (GO:0046087)2.55795181
138cytidine catabolic process (GO:0006216)2.55795181
139cytidine deamination (GO:0009972)2.55795181
140negative regulation of sodium ion transport (GO:0010766)2.55226754
141glutamate receptor signaling pathway (GO:0007215)2.54512477
142protein neddylation (GO:0045116)2.53803205
143nerve growth factor signaling pathway (GO:0038180)2.52173952
144neuron remodeling (GO:0016322)2.52004710
145positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51626530
146magnesium ion transport (GO:0015693)2.50846676
147regulation of mesenchymal cell apoptotic process (GO:2001053)2.50674898
148positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.50666991
149transmission of nerve impulse (GO:0019226)2.50532084
150chondrocyte proliferation (GO:0035988)2.50084201
151rhodopsin mediated signaling pathway (GO:0016056)2.49749169
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48669338
153regulation of germinal center formation (GO:0002634)2.48543224
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47775555
155positive regulation of icosanoid secretion (GO:0032305)2.47707432
156substrate-dependent cell migration (GO:0006929)2.47607336
157detection of light stimulus involved in sensory perception (GO:0050962)2.47439035
158detection of light stimulus involved in visual perception (GO:0050908)2.47439035
159regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.46711315
160regulation of Golgi to plasma membrane protein transport (GO:0042996)2.45371923
161positive regulation of fatty acid oxidation (GO:0046321)2.45053221
162collagen fibril organization (GO:0030199)2.44850342
163primary amino compound metabolic process (GO:1901160)2.43840258
164cellular response to exogenous dsRNA (GO:0071360)2.43791384
165cerebral cortex neuron differentiation (GO:0021895)2.43621756
166negative regulation of neurotransmitter transport (GO:0051589)2.43579981
167negative regulation of response to food (GO:0032096)2.43386619
168negative regulation of appetite (GO:0032099)2.43386619
169respiratory system process (GO:0003016)2.42838970
170sleep (GO:0030431)2.42727119
171glial cell migration (GO:0008347)2.42341993
172synaptic transmission, glutamatergic (GO:0035249)2.41662913
173regulation of axon extension involved in axon guidance (GO:0048841)2.41506965
174amino acid import (GO:0043090)2.40813308
175long-term synaptic potentiation (GO:0060291)2.40501168
176regulation of inositol phosphate biosynthetic process (GO:0010919)2.40217476
177negative regulation of telomerase activity (GO:0051974)2.39550469
178positive regulation of cAMP-mediated signaling (GO:0043950)2.38946875
179regulation of cell proliferation involved in kidney development (GO:1901722)2.38712721
180retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37921753
181body morphogenesis (GO:0010171)2.37243838
182positive regulation of extracellular matrix organization (GO:1903055)2.35908504
183startle response (GO:0001964)2.35713423
184kidney morphogenesis (GO:0060993)2.34655067
185regulation of neuronal synaptic plasticity (GO:0048168)2.34088571
186neuron-neuron synaptic transmission (GO:0007270)2.33895640
187otic vesicle formation (GO:0030916)2.32550901
188female mating behavior (GO:0060180)2.31848797
189regulation of dendritic spine morphogenesis (GO:0061001)2.31647657
190cardiac myofibril assembly (GO:0055003)2.31301147
191regulation of female receptivity (GO:0045924)2.30519053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.95189774
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46135990
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.29173938
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27358691
5* EZH2_27304074_Chip-Seq_ESCs_Mouse3.14555871
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10553116
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.10508115
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.10508115
9GBX2_23144817_ChIP-Seq_PC3_Human3.05556077
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.96288067
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.89188856
12AR_21572438_ChIP-Seq_LNCaP_Human2.83776296
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80308468
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.79583698
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75757035
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73921622
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72365536
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.63092458
19VDR_22108803_ChIP-Seq_LS180_Human2.45992879
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37818318
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.34548740
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.23765783
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20053057
24IGF1R_20145208_ChIP-Seq_DFB_Human2.19271032
25* CBX2_27304074_Chip-Seq_ESCs_Mouse2.16578177
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15144549
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14748674
28* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14604434
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07105646
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04178354
31ZNF274_21170338_ChIP-Seq_K562_Hela2.02886297
32TAF15_26573619_Chip-Seq_HEK293_Human1.98380395
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97265084
34IRF1_19129219_ChIP-ChIP_H3396_Human1.93651514
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92739393
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.90957374
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89154819
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85157553
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84858186
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80089438
41TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.79144648
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79031318
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.75956352
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.74256972
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.74115147
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.68001990
47FUS_26573619_Chip-Seq_HEK293_Human1.67593299
48MYC_18940864_ChIP-ChIP_HL60_Human1.67242847
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.66138175
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.62275289
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61844492
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57950783
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54532122
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51682657
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50704560
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.50608888
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50243912
58* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48829706
59BCAT_22108803_ChIP-Seq_LS180_Human1.45195403
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.43455001
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42323640
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40699095
63REST_21632747_ChIP-Seq_MESCs_Mouse1.39431432
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.39111819
65RNF2_27304074_Chip-Seq_NSC_Mouse1.39080889
66TP53_22573176_ChIP-Seq_HFKS_Human1.37189828
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36229976
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35513158
69P300_19829295_ChIP-Seq_ESCs_Human1.34076837
70CBP_20019798_ChIP-Seq_JUKART_Human1.32715178
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32715178
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29352617
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28832760
74TP53_18474530_ChIP-ChIP_U2OS_Human1.28746105
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28197304
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27166097
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.27166097
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26796284
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.26617267
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26305675
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25150569
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24701743
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24146933
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23936631
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23112341
86SOX2_19829295_ChIP-Seq_ESCs_Human1.21007559
87NANOG_19829295_ChIP-Seq_ESCs_Human1.21007559
88* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19780020
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19303271
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.18602539
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18209792
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18209792
93DROSHA_22980978_ChIP-Seq_HELA_Human1.17588484
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17024773
95VDR_23849224_ChIP-Seq_CD4+_Human1.16360873
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.16355323
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16276593
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15075524
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.14703473
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14055758
101IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13858882
102TCF4_23295773_ChIP-Seq_U87_Human1.11410397
103NCOR_22424771_ChIP-Seq_293T_Human1.11304779
104AR_20517297_ChIP-Seq_VCAP_Human1.10228672
105* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10084183
106* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09908609
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.09640200
108* RXR_22108803_ChIP-Seq_LS180_Human1.08935272
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08785472
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08616302
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08492124
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08492124
113* STAT3_23295773_ChIP-Seq_U87_Human1.08441655
114AR_25329375_ChIP-Seq_VCAP_Human1.08376963
115CJUN_26792858_Chip-Seq_BT549_Human1.08023843
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06917121
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.06472972
118AHR_22903824_ChIP-Seq_MCF-7_Human1.06115452
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05610160
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05350954
121* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05157556
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.05062784
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04210560
124ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03313530
125IRF8_22096565_ChIP-ChIP_GC-B_Human1.02806442
126GATA3_21878914_ChIP-Seq_MCF-7_Human1.02251116
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02159646
128ELK1_19687146_ChIP-ChIP_HELA_Human1.02155499
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.02097762
130TCF4_22108803_ChIP-Seq_LS180_Human1.01933071
131* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01457950
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01093901
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00339864
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.99789928
135EWS_26573619_Chip-Seq_HEK293_Human0.98532746
136AR_19668381_ChIP-Seq_PC3_Human0.97999956
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97768377
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97208542
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95644566
140JUN_21703547_ChIP-Seq_K562_Human0.95607183
141REST_18959480_ChIP-ChIP_MESCs_Mouse0.95359213
142P53_22387025_ChIP-Seq_ESCs_Mouse0.94335972
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93970958
144* ER_23166858_ChIP-Seq_MCF-7_Human0.92637061
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92567892
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91699100
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.89980712
148P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89617876
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89336258
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88552309
151* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88253760
152MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87535858
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87170969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009384_cardiac_valve_regurgitation4.79200611
2MP0006292_abnormal_olfactory_placode4.15859946
3MP0003941_abnormal_skin_development3.60583363
4MP0003880_abnormal_central_pattern3.16054312
5* MP0002282_abnormal_trachea_morphology2.93999474
6MP0009250_abnormal_appendicular_skeleto2.83714736
7MP0004859_abnormal_synaptic_plasticity2.67401322
8MP0008877_abnormal_DNA_methylation2.48649833
9MP0005503_abnormal_tendon_morphology2.47228575
10MP0004885_abnormal_endolymph2.44947759
11MP0001299_abnormal_eye_distance/2.44849856
12MP0002138_abnormal_hepatobiliary_system2.44458410
13MP0009780_abnormal_chondrocyte_physiolo2.37691927
14MP0000751_myopathy2.13435949
15* MP0000049_abnormal_middle_ear2.01421788
16MP0003635_abnormal_synaptic_transmissio2.00137794
17MP0001485_abnormal_pinna_reflex2.00127975
18MP0003724_increased_susceptibility_to1.98253542
19MP0002160_abnormal_reproductive_system1.97948984
20MP0003195_calcinosis1.95702828
21MP0003122_maternal_imprinting1.91660888
22MP0004134_abnormal_chest_morphology1.88332880
23MP0008872_abnormal_physiological_respon1.87884564
24MP0003011_delayed_dark_adaptation1.86482835
25MP0004142_abnormal_muscle_tone1.84822720
26MP0002909_abnormal_adrenal_gland1.84023502
27MP0003279_aneurysm1.83064614
28MP0008789_abnormal_olfactory_epithelium1.82356023
29MP0002876_abnormal_thyroid_physiology1.80216409
30MP0005551_abnormal_eye_electrophysiolog1.76312965
31MP0001968_abnormal_touch/_nociception1.75013232
32MP0009745_abnormal_behavioral_response1.72929295
33MP0002653_abnormal_ependyma_morphology1.71558748
34MP0001958_emphysema1.71402112
35MP0005389_reproductive_system_phenotype1.70071907
36MP0002063_abnormal_learning/memory/cond1.66975472
37MP0004133_heterotaxia1.66729481
38MP0003136_yellow_coat_color1.66451602
39* MP0005646_abnormal_pituitary_gland1.66271258
40MP0003385_abnormal_body_wall1.59738746
41MP0004272_abnormal_basement_membrane1.58244255
42MP0000163_abnormal_cartilage_morphology1.56522086
43MP0002064_seizures1.55656228
44MP0002736_abnormal_nociception_after1.50314644
45MP0000516_abnormal_urinary_system1.49809786
46MP0005367_renal/urinary_system_phenotyp1.49809786
47MP0003646_muscle_fatigue1.49640186
48MP0005670_abnormal_white_adipose1.49487229
49MP0005084_abnormal_gallbladder_morpholo1.49092741
50MP0005253_abnormal_eye_physiology1.49063280
51MP0004130_abnormal_muscle_cell1.46225602
52MP0000778_abnormal_nervous_system1.45241924
53MP0001986_abnormal_taste_sensitivity1.44928898
54MP0004858_abnormal_nervous_system1.44575164
55MP0002735_abnormal_chemical_nociception1.43440547
56MP0000762_abnormal_tongue_morphology1.43398662
57* MP0003942_abnormal_urinary_system1.42973114
58MP0003787_abnormal_imprinting1.41781827
59MP0004147_increased_porphyrin_level1.40268016
60MP0002249_abnormal_larynx_morphology1.40080888
61MP0005671_abnormal_response_to1.37571500
62MP0000013_abnormal_adipose_tissue1.36631852
63MP0002572_abnormal_emotion/affect_behav1.36178875
64MP0005423_abnormal_somatic_nervous1.36172577
65* MP0000428_abnormal_craniofacial_morphol1.35355845
66MP0001486_abnormal_startle_reflex1.34680412
67MP0003755_abnormal_palate_morphology1.34236415
68MP0004270_analgesia1.33204159
69MP0010030_abnormal_orbit_morphology1.30662821
70* MP0003938_abnormal_ear_development1.30213868
71* MP0003937_abnormal_limbs/digits/tail_de1.28438903
72MP0008775_abnormal_heart_ventricle1.26582792
73MP0002115_abnormal_skeleton_extremities1.25242763
74MP0002277_abnormal_respiratory_mucosa1.24502098
75MP0000749_muscle_degeneration1.23626597
76MP0004145_abnormal_muscle_electrophysio1.22908887
77MP0000613_abnormal_salivary_gland1.22543520
78MP0003137_abnormal_impulse_conducting1.21994692
79MP0003123_paternal_imprinting1.21907573
80* MP0002116_abnormal_craniofacial_bone1.21283115
81MP0002089_abnormal_postnatal_growth/wei1.20683178
82* MP0005508_abnormal_skeleton_morphology1.20059518
83* MP0002896_abnormal_bone_mineralization1.19292518
84MP0002163_abnormal_gland_morphology1.18207518
85MP0000383_abnormal_hair_follicle1.18175827
86MP0009046_muscle_twitch1.17846094
87MP0005645_abnormal_hypothalamus_physiol1.17526508
88MP0006276_abnormal_autonomic_nervous1.17243381
89MP0002233_abnormal_nose_morphology1.17097337
90MP0004215_abnormal_myocardial_fiber1.15128219
91MP0006138_congestive_heart_failure1.15110710
92MP0003329_amyloid_beta_deposits1.14729704
93MP0002734_abnormal_mechanical_nocicepti1.14288330
94MP0005499_abnormal_olfactory_system1.13033216
95MP0005394_taste/olfaction_phenotype1.13033216
96* MP0000537_abnormal_urethra_morphology1.12204600
97MP0001661_extended_life_span1.09686096
98MP0003172_abnormal_lysosome_physiology1.09207446
99MP0001919_abnormal_reproductive_system1.08084764
100MP0005623_abnormal_meninges_morphology1.07301109
101MP0003690_abnormal_glial_cell1.06971172
102MP0000372_irregular_coat_pigmentation1.05862142
103MP0002272_abnormal_nervous_system1.05581911
104MP0002184_abnormal_innervation1.04715933
105MP0001293_anophthalmia1.04526250
106MP0000230_abnormal_systemic_arterial1.04018493
107MP0002638_abnormal_pupillary_reflex1.03910342
108MP0002067_abnormal_sensory_capabilities1.03622733
109MP0005195_abnormal_posterior_eye1.02304197
110* MP0002109_abnormal_limb_morphology1.02078037
111MP0004084_abnormal_cardiac_muscle1.01789232
112MP0002733_abnormal_thermal_nociception1.01313649
113MP0001177_atelectasis0.99947722
114MP0004233_abnormal_muscle_weight0.98478754
115MP0002751_abnormal_autonomic_nervous0.97807824
116* MP0002113_abnormal_skeleton_development0.97522793
117MP0001542_abnormal_bone_strength0.97413942
118MP0002928_abnormal_bile_duct0.96589171
119MP0000534_abnormal_ureter_morphology0.96177697
120* MP0002108_abnormal_muscle_morphology0.95982494
121MP0002938_white_spotting0.95557712
122MP0008438_abnormal_cutaneous_collagen0.92888736
123MP0003121_genomic_imprinting0.92287898
124MP0001440_abnormal_grooming_behavior0.91372686
125MP0005360_urolithiasis0.90862681
126* MP0001963_abnormal_hearing_physiology0.90686341
127MP0003283_abnormal_digestive_organ0.90349152
128* MP0000026_abnormal_inner_ear0.89738615
129MP0001970_abnormal_pain_threshold0.89508747
130MP0002102_abnormal_ear_morphology0.89172832
131* MP0009053_abnormal_anal_canal0.89073855
132MP0002557_abnormal_social/conspecific_i0.88904980
133* MP0002932_abnormal_joint_morphology0.86328749
134MP0001943_abnormal_respiration0.86262055
135MP0001905_abnormal_dopamine_level0.85929783
136MP0005620_abnormal_muscle_contractility0.85650428
137MP0004924_abnormal_behavior0.84510043
138MP0005386_behavior/neurological_phenoty0.84510043
139MP0003567_abnormal_fetal_cardiomyocyte0.84466301
140* MP0002114_abnormal_axial_skeleton0.84367301
141* MP0002152_abnormal_brain_morphology0.84296728
142MP0002837_dystrophic_cardiac_calcinosis0.83747639
143MP0005174_abnormal_tail_pigmentation0.83576039
144MP0002972_abnormal_cardiac_muscle0.83379255
145MP0005075_abnormal_melanosome_morpholog0.83215045
146MP0004036_abnormal_muscle_relaxation0.82773248
147MP0002234_abnormal_pharynx_morphology0.81756087
148MP0001764_abnormal_homeostasis0.81357200
149* MP0003119_abnormal_digestive_system0.80951815
150* MP0002882_abnormal_neuron_morphology0.80827033
151* MP0000432_abnormal_head_morphology0.79857917
152MP0006072_abnormal_retinal_apoptosis0.79530760
153* MP0000631_abnormal_neuroendocrine_gland0.79382003
154MP0000747_muscle_weakness0.78658835
155MP0003936_abnormal_reproductive_system0.77632698
156MP0009765_abnormal_xenobiotic_induced0.75154791
157* MP0002752_abnormal_somatic_nervous0.74470062
158MP0003638_abnormal_response/metabolism_0.74456291
159MP0000639_abnormal_adrenal_gland0.74045846
160MP0004185_abnormal_adipocyte_glucose0.72423797
161MP0001119_abnormal_female_reproductive0.72418984
162MP0000678_abnormal_parathyroid_gland0.71171614
163MP0004742_abnormal_vestibular_system0.68048795
164MP0001501_abnormal_sleep_pattern0.67918036
165MP0008995_early_reproductive_senescence0.67609075
166MP0005377_hearing/vestibular/ear_phenot0.66580235
167MP0003878_abnormal_ear_physiology0.66580235
168MP0005410_abnormal_fertilization0.66540743
169MP0001529_abnormal_vocalization0.66245672

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)6.49033263
2Aplasia of the phalanges of the hand (HP:0009802)6.49033263
3Aplasia involving bones of the extremities (HP:0009825)6.49033263
4* Abnormality of the proximal phalanges of the hand (HP:0009834)5.65204767
5Epiphyseal dysplasia (HP:0002656)5.04528438
6Fibular aplasia (HP:0002990)4.43724771
7Abnormality of the phalanges of the 2nd finger (HP:0009541)4.39321605
8Pancreatic cysts (HP:0001737)4.19301647
9Aplasia/Hypoplasia of the fibula (HP:0006492)4.13570374
10True hermaphroditism (HP:0010459)3.83626393
11* Abnormality of the middle phalanges of the toes (HP:0010183)3.75570929
12Pancreatic fibrosis (HP:0100732)3.72499669
13Neonatal short-limb short stature (HP:0008921)3.65234888
14Vitreoretinal degeneration (HP:0000655)3.59871302
15Congenital stationary night blindness (HP:0007642)3.51503833
16Nephronophthisis (HP:0000090)3.50895436
17Pendular nystagmus (HP:0012043)3.46245300
18Abolished electroretinogram (ERG) (HP:0000550)3.43792100
19Irregular epiphyses (HP:0010582)3.41182631
20Flat capital femoral epiphysis (HP:0003370)3.39112593
21Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.36928103
22Asplenia (HP:0001746)3.36457068
23Fibular hypoplasia (HP:0003038)3.30746196
24Aplasia/Hypoplasia of the spleen (HP:0010451)3.28507333
25Abnormality of midbrain morphology (HP:0002418)3.28299026
26Molar tooth sign on MRI (HP:0002419)3.28299026
27Abnormality of the 2nd finger (HP:0004100)3.25561651
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.24183299
29* Short hallux (HP:0010109)3.19921023
30Concave nail (HP:0001598)3.16859520
31Stenosis of the external auditory canal (HP:0000402)3.12810451
32Keratoconus (HP:0000563)3.08315467
33Increased corneal curvature (HP:0100692)3.08315467
34* Abnormality of the phalanges of the 5th finger (HP:0004213)3.08123518
35Methylmalonic acidemia (HP:0002912)3.05253545
36* Aplasia/Hypoplasia of the hallux (HP:0008362)3.03498213
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98372122
38Sparse lateral eyebrow (HP:0005338)2.98360478
39Abnormality of the renal cortex (HP:0011035)2.93628924
40* Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.91876050
41Obstructive sleep apnea (HP:0002870)2.90512992
42Abnormality of the renal medulla (HP:0100957)2.89263424
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.89009866
44Mixed hearing impairment (HP:0000410)2.87521725
45Congenital, generalized hypertrichosis (HP:0004540)2.84644319
46Renal cortical cysts (HP:0000803)2.83784564
47Premature rupture of membranes (HP:0001788)2.70122317
48Bronchomalacia (HP:0002780)2.68906601
49Abnormal rod and cone electroretinograms (HP:0008323)2.68618310
50* Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.61798086
513-Methylglutaconic aciduria (HP:0003535)2.59938689
52Hypoplastic ischia (HP:0003175)2.59506087
53Acute necrotizing encephalopathy (HP:0006965)2.55489612
54Abnormality of the ischium (HP:0003174)2.54954620
55Chorioretinal atrophy (HP:0000533)2.53107348
56Type II lissencephaly (HP:0007260)2.52416828
57Hypoplasia of the uterus (HP:0000013)2.51395594
58Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.49634241
59* Symphalangism affecting the phalanges of the hand (HP:0009773)2.49441447
60Aplasia/hypoplasia of the uterus (HP:0008684)2.48553630
61Methylmalonic aciduria (HP:0012120)2.47956736
62Decreased central vision (HP:0007663)2.45459284
63Cystic liver disease (HP:0006706)2.43348775
64Cervical subluxation (HP:0003308)2.42544921
65Mild short stature (HP:0003502)2.42385663
66Abnormality of DNA repair (HP:0003254)2.40895635
67Absent thumb (HP:0009777)2.40340360
68Adrenal hypoplasia (HP:0000835)2.38624642
69Sclerocornea (HP:0000647)2.37954572
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37447659
71Focal motor seizures (HP:0011153)2.36830971
72Short femoral neck (HP:0100864)2.36759724
73Attenuation of retinal blood vessels (HP:0007843)2.36247581
74IgG deficiency (HP:0004315)2.35761188
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34580767
76Genetic anticipation (HP:0003743)2.34418266
77Cupped ribs (HP:0000887)2.33571388
78Mitochondrial inheritance (HP:0001427)2.32659240
79Abnormality of the fibula (HP:0002991)2.31160212
80Aplasia/hypoplasia of the femur (HP:0005613)2.30470883
81Abnormal mitochondria in muscle tissue (HP:0008316)2.30416163
82* Abnormality of the middle phalanges of the hand (HP:0009833)2.27521984
83Short tibia (HP:0005736)2.27163219
84Progressive macrocephaly (HP:0004481)2.26443702
85Limited hip movement (HP:0008800)2.26071650
86Medial flaring of the eyebrow (HP:0010747)2.25142138
87Abnormality of the renal collecting system (HP:0004742)2.23386095
88Narrow nasal bridge (HP:0000446)2.22891820
89Bile duct proliferation (HP:0001408)2.20889116
90Abnormal biliary tract physiology (HP:0012439)2.20889116
91Congenital sensorineural hearing impairment (HP:0008527)2.18266334
92Osteoarthritis (HP:0002758)2.18082144
93Spinal cord compression (HP:0002176)2.18072736
94Thyroiditis (HP:0100646)2.16377879
95Carpal bone hypoplasia (HP:0001498)2.12528127
96Myokymia (HP:0002411)2.11857930
97Hypoplasia of the odontoid process (HP:0003311)2.10926843
98Severe combined immunodeficiency (HP:0004430)2.09311864
99Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.07818175
100Adactyly (HP:0009776)2.06481361
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.06200824
102Progressive cerebellar ataxia (HP:0002073)2.05869660
103Increased CSF lactate (HP:0002490)2.05688574
104Acute encephalopathy (HP:0006846)2.04302536
105* Synostosis of carpal bones (HP:0005048)2.03712856
106Tracheomalacia (HP:0002779)2.03567372
107Thyroid-stimulating hormone excess (HP:0002925)2.03355936
108Focal seizures (HP:0007359)2.02820932
109Thin ribs (HP:0000883)2.01059574
110Decreased subcutaneous fat (HP:0001002)2.01057997
111Hepatocellular necrosis (HP:0001404)2.00997051
112Sleep apnea (HP:0010535)1.99518173
113Hyperglycinemia (HP:0002154)1.98572451
114Exostoses (HP:0100777)1.97688234
115Male pseudohermaphroditism (HP:0000037)1.97535037
116* Tarsal synostosis (HP:0008368)1.97211964
117Prostate neoplasm (HP:0100787)1.97202192
118Postaxial foot polydactyly (HP:0001830)1.97027234
119Stomach cancer (HP:0012126)1.96729777
120Abnormality of the pubic bones (HP:0003172)1.96354335
121Severe muscular hypotonia (HP:0006829)1.95974050
122Congenital hepatic fibrosis (HP:0002612)1.94995965
123Porencephaly (HP:0002132)1.94146332
124Absent/shortened dynein arms (HP:0200106)1.94078478
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.94078478
126Agitation (HP:0000713)1.92699779
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.92194987
128Optic nerve hypoplasia (HP:0000609)1.91533980
129Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.90657087
130Ectopic kidney (HP:0000086)1.90368562
131Infantile muscular hypotonia (HP:0008947)1.86341940
132Atonic seizures (HP:0010819)1.85171696
133Furrowed tongue (HP:0000221)1.84528896
134Chronic hepatic failure (HP:0100626)1.84393975
135* Synostosis involving bones of the lower limbs (HP:0009138)1.82190595
136* Synostosis involving bones of the feet (HP:0009140)1.82190595
137Abnormal vertebral ossification (HP:0100569)1.81753567
138Anencephaly (HP:0002323)1.81136640
139Abnormality of alanine metabolism (HP:0010916)1.79724417
140Hyperalaninemia (HP:0003348)1.79724417
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79724417
142Hepatic necrosis (HP:0002605)1.79496320
143Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79408489
144Tubular atrophy (HP:0000092)1.77384477
145Depressed nasal tip (HP:0000437)1.77345588
146Papilledema (HP:0001085)1.77092229
147* Broad hallux (HP:0010055)1.76486725
148Small hand (HP:0200055)1.76423859
149* Broad toe (HP:0001837)1.76390739
150Bony spicule pigmentary retinopathy (HP:0007737)1.75802858
151Optic disc pallor (HP:0000543)1.75657772
152Abnormality of the odontoid process (HP:0003310)1.75650554
153Aplasia/Hypoplasia of the ulna (HP:0006495)1.73475102
154Genu varum (HP:0002970)1.73436454
155Delayed epiphyseal ossification (HP:0002663)1.73435506
156Gaze-evoked nystagmus (HP:0000640)1.73385651
157Protrusio acetabuli (HP:0003179)1.72428441
158Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72080053
159Hypoplasia of the ulna (HP:0003022)1.71705694
160Abnormality of the epiphyses of the hand (HP:0005924)1.71021130
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.70789903
162Bilateral microphthalmos (HP:0007633)1.70702894
163Popliteal pterygium (HP:0009756)1.70671318
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.69840009
165Hypoplasia of the fovea (HP:0007750)1.69840009
166Abnormal drinking behavior (HP:0030082)1.69035802
167Polydipsia (HP:0001959)1.69035802
168Shallow orbits (HP:0000586)1.67760209
169Short nail (HP:0001799)1.65404633
170Small epiphyses (HP:0010585)1.64664005
171Radial bowing (HP:0002986)1.64365677
172Limited elbow extension (HP:0001377)1.63951855
173* Carpal synostosis (HP:0009702)1.63670980
174Hypoplasia of the iris (HP:0007676)1.60151522
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59835230
176Hemiparesis (HP:0001269)1.59744072
177Mesomelia (HP:0003027)1.58858642
178Abnormality of carpal bone ossification (HP:0006257)1.58210052
179Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58165060
180Neonatal hypoglycemia (HP:0001998)1.56111026
181Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.56099734
182Abnormality of femoral epiphyses (HP:0006499)1.56099734
183Abnormal tarsal ossification (HP:0008369)1.55545308
184Abnormality of the calf musculature (HP:0001430)1.55496683
185* Dislocated radial head (HP:0003083)1.54861737
186Exercise-induced myalgia (HP:0003738)1.54573351
187* Abnormality of the humeroradial joint (HP:0100744)1.54044996
188Relative macrocephaly (HP:0004482)1.53328869
189Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.52946848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.31370821
2INSRR4.27889494
3FRK3.58883773
4GRK13.47153989
5MAP4K23.41798708
6TAOK33.26571727
7NTRK33.22122794
8DDR23.03823097
9ADRBK22.95300291
10EPHB22.83683249
11TLK12.80670064
12PINK12.75367145
13EPHA42.74535150
14NUAK12.58738045
15TXK2.55168655
16NME12.23454553
17ZAK2.18958919
18WNK32.18855615
19PRKD32.14978440
20MARK12.09640892
21BCKDK2.08400095
22PHKG12.03969463
23PHKG22.03969463
24MINK12.03707737
25ICK1.98089258
26PRPF4B1.83666830
27MUSK1.76813507
28PLK21.76649209
29CLK11.68064726
30VRK21.64157013
31LATS21.54545146
32ERBB31.53792056
33MAPK131.52981329
34PDGFRA1.49471357
35MAP3K41.48905178
36TIE11.44005241
37NTRK11.41840167
38BMPR1B1.41094382
39FER1.38366358
40CSNK1G31.38176627
41TAOK11.34371194
42STK241.34286834
43CSNK1G21.31876559
44FGFR21.30434724
45FLT31.27984294
46PRKCG1.24017759
47PAK31.22506409
48WNK41.22043497
49CSNK1G11.19723340
50UHMK11.19497566
51CAMK2A1.18706428
52GRK71.18665699
53STK391.18059255
54TTN1.15864427
55DAPK21.12946577
56OXSR11.12464578
57CDK191.10390932
58ACVR1B1.09299807
59MAP2K71.08903559
60OBSCN1.08245668
61DYRK21.07512432
62MKNK21.06895065
63TRIM281.06300043
64CDK141.06196444
65NTRK21.04598932
66CSNK1A1L1.04259373
67ERBB41.01729353
68GRK51.01674653
69MAP2K11.01448972
70CAMK2B1.01325311
71STK160.98311180
72VRK10.98074231
73IKBKB0.96318123
74ROCK10.94927673
75MAP2K40.94133746
76TAOK20.93475530
77DMPK0.92527323
78PDK40.92372896
79PDK30.92372896
80KIT0.92349261
81KSR10.92235397
82CAMKK20.90729724
83PLK40.89949523
84MAPK120.89458408
85PRKCE0.88069103
86FES0.86980257
87MAPK70.85293597
88TEC0.84944177
89PAK20.81980380
90GRK60.80504292
91CAMK2D0.78543554
92CDK50.76731591
93MAP2K20.76071851
94MAP3K90.75740843
95KDR0.74901318
96CDK180.74403981
97SGK20.74360697
98CDK150.74355914
99LIMK10.74311253
100ITK0.73527714
101PNCK0.72754778
102PRKCQ0.71856533
103CAMK2G0.70972195
104PAK60.70109885
105PRKG10.69986628
106CDK30.68958407
107LRRK20.68561784
108PIK3CA0.67834429
109PDK20.67666713
110ADRBK10.66784500
111ROCK20.66633376
112MAPKAPK30.66185479
113RPS6KA50.66171834
114DYRK1A0.65340897
115MAP2K60.65326316
116PRKD20.63652124
117CDK80.63512314
118CDK11A0.63121317
119SGK2230.62433882
120SGK4940.62433882
121STK110.61936624
122CSNK1A10.61891161
123MAPKAPK50.60954557
124ILK0.60361245
125BCR0.60231041
126CDK90.59151232
127CAMK40.59016076
128TYRO30.58715302
129PRKG20.57863175
130SYK0.57084396
131RPS6KA60.55534805
132NEK60.52933658
133LCK0.51345675
134TNIK0.50107430
135SGK10.49397337
136IRAK20.48053310
137TGFBR10.47487538
138EIF2AK20.47002463
139BRSK20.46908570
140TNK20.46431083
141MAP4K10.46275229
142LYN0.46206433
143SIK20.46168929
144MYLK0.44852070
145IGF1R0.44844595
146CAMKK10.44584569
147PRKACA0.44537822
148ATR0.44068853
149PTK2B0.42959051
150ABL10.42366588
151MKNK10.41882181
152DAPK10.41566634
153CAMK10.40681375
154MAPK150.40535789
155PLK10.39136845
156PRKCA0.38956366
157ERBB20.38879583
158IKBKE0.38587896
159PKN10.37841969
160TAF10.37787596
161AURKA0.36968965
162MAPK40.36643273
163EIF2AK30.34889090
164SRC0.34843114
165FGFR10.34667177
166PLK30.34453140
167SRPK10.31199268
168CSF1R0.30379833

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.51922573
2Nicotine addiction_Homo sapiens_hsa050332.80105949
3Phototransduction_Homo sapiens_hsa047442.79052838
4Cardiac muscle contraction_Homo sapiens_hsa042602.20465168
5Dilated cardiomyopathy_Homo sapiens_hsa054142.12339765
6GABAergic synapse_Homo sapiens_hsa047272.12250858
7Homologous recombination_Homo sapiens_hsa034402.05494552
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02706282
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01843519
10Linoleic acid metabolism_Homo sapiens_hsa005911.98586557
11Circadian entrainment_Homo sapiens_hsa047131.96131229
12Primary immunodeficiency_Homo sapiens_hsa053401.89754655
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88701243
14Amphetamine addiction_Homo sapiens_hsa050311.87719821
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87129993
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86505905
17ECM-receptor interaction_Homo sapiens_hsa045121.85879244
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.85735504
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84198041
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81106241
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81097180
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81012608
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80010758
24Glutamatergic synapse_Homo sapiens_hsa047241.79030828
25Protein export_Homo sapiens_hsa030601.78453098
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76547637
27Olfactory transduction_Homo sapiens_hsa047401.72900424
28RNA polymerase_Homo sapiens_hsa030201.72825590
29Synaptic vesicle cycle_Homo sapiens_hsa047211.69257357
30Long-term potentiation_Homo sapiens_hsa047201.67639653
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66473239
32Salivary secretion_Homo sapiens_hsa049701.65519403
33RNA degradation_Homo sapiens_hsa030181.65516807
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.62225265
35Fanconi anemia pathway_Homo sapiens_hsa034601.60789135
36Morphine addiction_Homo sapiens_hsa050321.60073828
37Oxidative phosphorylation_Homo sapiens_hsa001901.57142417
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57136528
39Asthma_Homo sapiens_hsa053101.54646929
40Gap junction_Homo sapiens_hsa045401.54294253
41Hedgehog signaling pathway_Homo sapiens_hsa043401.49394584
42Dopaminergic synapse_Homo sapiens_hsa047281.47379650
43Melanogenesis_Homo sapiens_hsa049161.44473176
44Gastric acid secretion_Homo sapiens_hsa049711.43471281
45Calcium signaling pathway_Homo sapiens_hsa040201.42707207
46Hippo signaling pathway_Homo sapiens_hsa043901.42219371
47Axon guidance_Homo sapiens_hsa043601.38802388
48Chemical carcinogenesis_Homo sapiens_hsa052041.37466599
49Basal cell carcinoma_Homo sapiens_hsa052171.36566146
50Long-term depression_Homo sapiens_hsa047301.36529239
51Oxytocin signaling pathway_Homo sapiens_hsa049211.36363734
52Renin secretion_Homo sapiens_hsa049241.34757017
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33311450
54Focal adhesion_Homo sapiens_hsa045101.30345378
55Insulin secretion_Homo sapiens_hsa049111.29605001
56Nitrogen metabolism_Homo sapiens_hsa009101.28414323
57Basal transcription factors_Homo sapiens_hsa030221.26071009
58Fatty acid biosynthesis_Homo sapiens_hsa000611.25843571
59Retinol metabolism_Homo sapiens_hsa008301.24891902
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24217532
61Parkinsons disease_Homo sapiens_hsa050121.23573596
62Ribosome_Homo sapiens_hsa030101.21857815
63Tryptophan metabolism_Homo sapiens_hsa003801.21623447
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20904412
65Vibrio cholerae infection_Homo sapiens_hsa051101.19838519
66Cholinergic synapse_Homo sapiens_hsa047251.18887699
67Allograft rejection_Homo sapiens_hsa053301.17276143
68Cocaine addiction_Homo sapiens_hsa050301.16860444
69Wnt signaling pathway_Homo sapiens_hsa043101.16347220
70Graft-versus-host disease_Homo sapiens_hsa053321.15594565
71Taste transduction_Homo sapiens_hsa047421.14367415
72Steroid hormone biosynthesis_Homo sapiens_hsa001401.14196167
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13980167
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13158181
75Autoimmune thyroid disease_Homo sapiens_hsa053201.09142761
76cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09002133
77Selenocompound metabolism_Homo sapiens_hsa004501.08729154
78Alzheimers disease_Homo sapiens_hsa050101.08694627
79Protein digestion and absorption_Homo sapiens_hsa049741.08178268
80Ether lipid metabolism_Homo sapiens_hsa005651.08029068
81Dorso-ventral axis formation_Homo sapiens_hsa043201.07615626
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06263421
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03934573
84Type I diabetes mellitus_Homo sapiens_hsa049401.03799004
85Caffeine metabolism_Homo sapiens_hsa002321.03406495
86Collecting duct acid secretion_Homo sapiens_hsa049661.03176033
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03114465
88Glioma_Homo sapiens_hsa052141.01968789
89Arachidonic acid metabolism_Homo sapiens_hsa005900.99178623
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97359379
91Peroxisome_Homo sapiens_hsa041460.97141894
92cAMP signaling pathway_Homo sapiens_hsa040240.97032407
93Butanoate metabolism_Homo sapiens_hsa006500.95295367
94Proteasome_Homo sapiens_hsa030500.94466206
95* TGF-beta signaling pathway_Homo sapiens_hsa043500.92286814
96Serotonergic synapse_Homo sapiens_hsa047260.91999786
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91598320
98GnRH signaling pathway_Homo sapiens_hsa049120.91268805
99Tight junction_Homo sapiens_hsa045300.90001500
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88309278
101Glycerolipid metabolism_Homo sapiens_hsa005610.87375773
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84794594
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84216866
104Rap1 signaling pathway_Homo sapiens_hsa040150.84004345
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83642714
106Huntingtons disease_Homo sapiens_hsa050160.82891946
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82202565
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.82035467
109Choline metabolism in cancer_Homo sapiens_hsa052310.81893711
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.81486919
111Proteoglycans in cancer_Homo sapiens_hsa052050.81306406
112Nucleotide excision repair_Homo sapiens_hsa034200.75817015
113Thyroid hormone synthesis_Homo sapiens_hsa049180.74978365
114MAPK signaling pathway_Homo sapiens_hsa040100.74473139
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73642527
116Regulation of autophagy_Homo sapiens_hsa041400.73093089
117Purine metabolism_Homo sapiens_hsa002300.71210154
118Pyrimidine metabolism_Homo sapiens_hsa002400.71081357
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69924972
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69631926
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68829132
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68227481
123Estrogen signaling pathway_Homo sapiens_hsa049150.67678098
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67585973
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66833392
126Hematopoietic cell lineage_Homo sapiens_hsa046400.66628503
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65226255
128Sulfur metabolism_Homo sapiens_hsa009200.64444389
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64229208
130Bile secretion_Homo sapiens_hsa049760.64111220
131Melanoma_Homo sapiens_hsa052180.63225091
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63110741
133Propanoate metabolism_Homo sapiens_hsa006400.62466667
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61682446
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.61595750
136Fat digestion and absorption_Homo sapiens_hsa049750.60007116
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59164214
138Rheumatoid arthritis_Homo sapiens_hsa053230.59091765
139ErbB signaling pathway_Homo sapiens_hsa040120.58562708
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58127396
141Prion diseases_Homo sapiens_hsa050200.56044689
142Antigen processing and presentation_Homo sapiens_hsa046120.56036333
143Glucagon signaling pathway_Homo sapiens_hsa049220.55979954
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.54533464
145Systemic lupus erythematosus_Homo sapiens_hsa053220.53567271
146One carbon pool by folate_Homo sapiens_hsa006700.53476011
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.53381310
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52596516
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52119426
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51776924
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51609877
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50410468
153Metabolic pathways_Homo sapiens_hsa011000.49687476
154N-Glycan biosynthesis_Homo sapiens_hsa005100.48733360
155Amoebiasis_Homo sapiens_hsa051460.48263754
156Renal cell carcinoma_Homo sapiens_hsa052110.48169587
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47629377
158Sulfur relay system_Homo sapiens_hsa041220.47116137
159Oocyte meiosis_Homo sapiens_hsa041140.46602224
160p53 signaling pathway_Homo sapiens_hsa041150.46360187
161AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45631299
162Ras signaling pathway_Homo sapiens_hsa040140.45043353
163Mineral absorption_Homo sapiens_hsa049780.44637843
164Type II diabetes mellitus_Homo sapiens_hsa049300.40292514
165Adherens junction_Homo sapiens_hsa045200.38808913
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37776557
167Base excision repair_Homo sapiens_hsa034100.36375731
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33610891
169Mismatch repair_Homo sapiens_hsa034300.31234291
170Steroid biosynthesis_Homo sapiens_hsa001000.29551624

Most similar genes based on co-expression Upload to Enrichr

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