NOL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.71742175
2purine nucleobase biosynthetic process (GO:0009113)4.54551650
3DNA strand elongation involved in DNA replication (GO:0006271)4.51901640
4DNA replication initiation (GO:0006270)4.51772822
5mitotic metaphase plate congression (GO:0007080)4.49045500
6establishment of integrated proviral latency (GO:0075713)4.48901586
7DNA strand elongation (GO:0022616)4.31295688
8ribosome assembly (GO:0042255)4.25368200
9telomere maintenance via semi-conservative replication (GO:0032201)4.23924146
10DNA unwinding involved in DNA replication (GO:0006268)4.19610701
11protein localization to kinetochore (GO:0034501)4.13672347
12DNA replication checkpoint (GO:0000076)4.10568001
13CENP-A containing nucleosome assembly (GO:0034080)4.07396380
14DNA replication-dependent nucleosome assembly (GO:0006335)4.06923527
15DNA replication-dependent nucleosome organization (GO:0034723)4.06923527
16formation of translation preinitiation complex (GO:0001731)4.03776668
17ribosome biogenesis (GO:0042254)4.03438642
18chromatin remodeling at centromere (GO:0031055)4.02749134
19nuclear pore organization (GO:0006999)3.95124806
20telomere maintenance via recombination (GO:0000722)3.94969502
21IMP biosynthetic process (GO:0006188)3.94198305
22pore complex assembly (GO:0046931)3.87783268
23DNA replication-independent nucleosome organization (GO:0034724)3.85454979
24DNA replication-independent nucleosome assembly (GO:0006336)3.85454979
25mitotic recombination (GO:0006312)3.84690360
26* maturation of SSU-rRNA (GO:0030490)3.81663457
27metaphase plate congression (GO:0051310)3.79904795
28mitotic nuclear envelope disassembly (GO:0007077)3.79612504
29ribosomal small subunit assembly (GO:0000028)3.79270493
30mitotic sister chromatid cohesion (GO:0007064)3.72199440
31ribonucleoprotein complex biogenesis (GO:0022613)3.68271712
32regulation of centriole replication (GO:0046599)3.66952686
33double-strand break repair via nonhomologous end joining (GO:0006303)3.66670210
34non-recombinational repair (GO:0000726)3.66670210
35regulation of spindle organization (GO:0090224)3.65030468
36nuclear pore complex assembly (GO:0051292)3.64801648
37telomere maintenance via telomere lengthening (GO:0010833)3.62545757
38ribosomal large subunit biogenesis (GO:0042273)3.60171671
39spliceosomal snRNP assembly (GO:0000387)3.58988507
40regulation of mitotic spindle checkpoint (GO:1903504)3.58627400
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58627400
42folic acid-containing compound biosynthetic process (GO:0009396)3.57047849
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.55610471
44DNA double-strand break processing (GO:0000729)3.54312049
45kinetochore organization (GO:0051383)3.52715649
46regulation of helicase activity (GO:0051095)3.51257127
47* rRNA processing (GO:0006364)3.49196209
48membrane disassembly (GO:0030397)3.48416988
49nuclear envelope disassembly (GO:0051081)3.48416988
50establishment of viral latency (GO:0019043)3.47967976
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45680154
52protein localization to chromosome, centromeric region (GO:0071459)3.44973603
53cullin deneddylation (GO:0010388)3.44616688
54histone exchange (GO:0043486)3.42122328
55* rRNA metabolic process (GO:0016072)3.38578116
56viral mRNA export from host cell nucleus (GO:0046784)3.38489892
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38267041
58negative regulation of ligase activity (GO:0051352)3.38267041
59IMP metabolic process (GO:0046040)3.37337834
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.34499097
61establishment of chromosome localization (GO:0051303)3.32509418
62DNA deamination (GO:0045006)3.29011206
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28558361
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.28558361
65transcription-coupled nucleotide-excision repair (GO:0006283)3.26618895
66tRNA aminoacylation for protein translation (GO:0006418)3.24680673
67attachment of spindle microtubules to kinetochore (GO:0008608)3.24242744
68protein K6-linked ubiquitination (GO:0085020)3.23960265
69DNA ligation (GO:0006266)3.22536465
70spindle checkpoint (GO:0031577)3.22352301
71kinetochore assembly (GO:0051382)3.22309933
72protein deneddylation (GO:0000338)3.22239893
73amino acid activation (GO:0043038)3.21748331
74tRNA aminoacylation (GO:0043039)3.21748331
75positive regulation of chromosome segregation (GO:0051984)3.21319671
76regulation of mitotic sister chromatid separation (GO:0010965)3.21295708
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20051465
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19781980
79rRNA modification (GO:0000154)3.18574044
80maturation of 5.8S rRNA (GO:0000460)3.18548558
81regulation of translational fidelity (GO:0006450)3.16665285
82mitotic sister chromatid segregation (GO:0000070)3.16617795
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16248411
84negative regulation of sister chromatid segregation (GO:0033046)3.16248411
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.16248411
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16248411
87negative regulation of chromosome segregation (GO:0051985)3.16124054
88DNA catabolic process, exonucleolytic (GO:0000738)3.16024747
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15947693
90DNA damage response, detection of DNA damage (GO:0042769)3.14429321
91spliceosomal complex assembly (GO:0000245)3.13850789
92spindle assembly checkpoint (GO:0071173)3.13780019
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13698377
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12637174
95mitotic spindle checkpoint (GO:0071174)3.11607210
96DNA topological change (GO:0006265)3.11565193
97regulation of centrosome cycle (GO:0046605)3.11445618
98replication fork processing (GO:0031297)3.10893959
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10745456
100mitotic spindle assembly checkpoint (GO:0007094)3.10349498
101transcription elongation from RNA polymerase III promoter (GO:0006385)3.09986224
102termination of RNA polymerase III transcription (GO:0006386)3.09986224
103regulation of mitotic spindle organization (GO:0060236)3.09491064
104translational initiation (GO:0006413)3.09449760
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.08837624
106translational termination (GO:0006415)3.08247851
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06656958
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05666842
109viral transcription (GO:0019083)3.05177457
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04646461
111mitochondrial RNA metabolic process (GO:0000959)3.04307743
112termination of RNA polymerase I transcription (GO:0006363)3.04063855
113RNA splicing, via transesterification reactions (GO:0000375)3.03880873
114regulation of chromosome segregation (GO:0051983)3.03740960
115negative regulation of DNA-dependent DNA replication (GO:2000104)3.03621581
116cell cycle G1/S phase transition (GO:0044843)3.02986076
117G1/S transition of mitotic cell cycle (GO:0000082)3.02986076
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02693856
119histone mRNA metabolic process (GO:0008334)3.02448462
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02041345
121mRNA splicing, via spliceosome (GO:0000398)3.01989679
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01989679
123rRNA methylation (GO:0031167)3.01956605
124mitotic chromosome condensation (GO:0007076)3.00354775
125ribosomal small subunit biogenesis (GO:0042274)2.99980476
126proteasome assembly (GO:0043248)2.99848809
127telomere maintenance (GO:0000723)2.97718951
128telomere organization (GO:0032200)2.96728387
129sister chromatid segregation (GO:0000819)2.96590635
130regulation of sister chromatid segregation (GO:0033045)2.95380586
131regulation of mitotic sister chromatid segregation (GO:0033047)2.95380586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.86603227
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50755017
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03424968
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.88574968
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54588921
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30944010
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28702604
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19158002
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.12601126
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11631861
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02904611
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99481959
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.95573458
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88656869
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87311875
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63438376
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52153633
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50710866
19* VDR_23849224_ChIP-Seq_CD4+_Human2.39557127
20XRN2_22483619_ChIP-Seq_HELA_Human2.35469806
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31818939
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25380483
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22004558
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18140965
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17839402
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05853570
27AR_21909140_ChIP-Seq_LNCAP_Human2.04940361
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03616240
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02562836
30ELK1_19687146_ChIP-ChIP_HELA_Human2.01723820
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.01285412
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99807901
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98960947
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97076945
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94082807
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92400612
37DCP1A_22483619_ChIP-Seq_HELA_Human1.91578612
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90419899
39TTF2_22483619_ChIP-Seq_HELA_Human1.89700493
40GABP_19822575_ChIP-Seq_HepG2_Human1.84935071
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80557044
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.76494608
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75417457
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75240570
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72384832
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71887320
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69151054
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.58792701
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57352106
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57061766
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.56228220
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54846001
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.53780458
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52486106
55CIITA_25753668_ChIP-Seq_RAJI_Human1.51688562
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49469618
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46907903
58KDM5A_27292631_Chip-Seq_BREAST_Human1.44718014
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.43280440
60* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38492514
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35914242
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35642504
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32245501
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29676574
65EWS_26573619_Chip-Seq_HEK293_Human1.28973428
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27437839
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.24799200
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20190849
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17975806
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17896229
71MYC_22102868_ChIP-Seq_BL_Human1.17070719
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16882054
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15959782
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14675244
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12781826
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11697116
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08856218
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07210114
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06014986
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04386987
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03984829
82TFEB_21752829_ChIP-Seq_HELA_Human1.01880406
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01431486
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.98648268
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98116209
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98116209
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98116209
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.98048676
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96996414
90FUS_26573619_Chip-Seq_HEK293_Human0.96919933
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96590285
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96424105
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95971493
94MYC_18940864_ChIP-ChIP_HL60_Human0.94600520
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93021885
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93006696
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91781932
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91520427
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90881202
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88844754
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86452920
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.86269452
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85201140
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84226387
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83484267
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83098870
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.82812350
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81897216
109IRF1_19129219_ChIP-ChIP_H3396_Human0.80894357
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.80622208
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.79306867
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78884156
113ZNF274_21170338_ChIP-Seq_K562_Hela0.77200899
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76976770
115CHD1_26751641_Chip-Seq_LNCaP_Human0.67469531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.34058462
2MP0010094_abnormal_chromosome_stability5.02651269
3MP0003111_abnormal_nucleus_morphology4.64203860
4MP0008057_abnormal_DNA_replication4.63712636
5MP0004957_abnormal_blastocyst_morpholog4.43605916
6MP0003077_abnormal_cell_cycle4.14633067
7MP0008058_abnormal_DNA_repair3.71671438
8MP0008007_abnormal_cellular_replicative3.20667037
9MP0008932_abnormal_embryonic_tissue2.76602980
10MP0008877_abnormal_DNA_methylation2.62537515
11MP0003123_paternal_imprinting2.48599627
12MP0002396_abnormal_hematopoietic_system2.45625367
13MP0000350_abnormal_cell_proliferation2.26124724
14MP0001730_embryonic_growth_arrest2.23121662
15MP0003786_premature_aging2.15841384
16MP0010307_abnormal_tumor_latency2.02879942
17MP0006292_abnormal_olfactory_placode1.92986955
18MP0003718_maternal_effect1.92129867
19MP0001672_abnormal_embryogenesis/_devel1.78673447
20MP0005380_embryogenesis_phenotype1.78673447
21MP0000537_abnormal_urethra_morphology1.75007923
22MP0001697_abnormal_embryo_size1.72090177
23MP0010352_gastrointestinal_tract_polyps1.68395980
24MP0003121_genomic_imprinting1.59926836
25MP0002085_abnormal_embryonic_tissue1.58143986
26MP0003984_embryonic_growth_retardation1.57701575
27MP0002080_prenatal_lethality1.56756111
28MP0001293_anophthalmia1.55933000
29MP0002088_abnormal_embryonic_growth/wei1.53033144
30MP0000490_abnormal_crypts_of1.51635077
31MP0002084_abnormal_developmental_patter1.48604333
32MP0000372_irregular_coat_pigmentation1.41154132
33MP0003890_abnormal_embryonic-extraembry1.40127645
34MP0004197_abnormal_fetal_growth/weight/1.37181153
35MP0002132_abnormal_respiratory_system1.35682616
36MP0002086_abnormal_extraembryonic_tissu1.34319644
37MP0004808_abnormal_hematopoietic_stem1.32971069
38MP0000313_abnormal_cell_death1.32414147
39MP0003567_abnormal_fetal_cardiomyocyte1.30898819
40MP0006035_abnormal_mitochondrial_morpho1.30896896
41MP0003315_abnormal_perineum_morphology1.30413116
42MP0002019_abnormal_tumor_incidence1.24728996
43MP0001661_extended_life_span1.22125776
44MP0003941_abnormal_skin_development1.19925086
45MP0002210_abnormal_sex_determination1.14433114
46MP0000569_abnormal_digit_pigmentation1.13924553
47MP0002160_abnormal_reproductive_system1.13567130
48MP0010030_abnormal_orbit_morphology1.11273485
49MP0002938_white_spotting1.09324550
50MP0006036_abnormal_mitochondrial_physio1.08982609
51MP0009333_abnormal_splenocyte_physiolog1.08277266
52MP0005408_hypopigmentation1.07966129
53MP0009053_abnormal_anal_canal1.07807592
54MP0003763_abnormal_thymus_physiology1.05769836
55MP0000703_abnormal_thymus_morphology1.02983286
56MP0001145_abnormal_male_reproductive1.02462235
57MP0003119_abnormal_digestive_system1.01247207
58MP0004147_increased_porphyrin_level0.97834519
59MP0003937_abnormal_limbs/digits/tail_de0.97357329
60MP0004233_abnormal_muscle_weight0.96679756
61MP0005367_renal/urinary_system_phenotyp0.95706907
62MP0000516_abnormal_urinary_system0.95706907
63MP0004264_abnormal_extraembryonic_tissu0.93840859
64MP0003186_abnormal_redox_activity0.93747542
65MP0003943_abnormal_hepatobiliary_system0.91368165
66MP0002111_abnormal_tail_morphology0.89389318
67MP0004133_heterotaxia0.88845393
68MP0001286_abnormal_eye_development0.88838985
69MP0006072_abnormal_retinal_apoptosis0.88636893
70MP0002163_abnormal_gland_morphology0.88093730
71MP0002751_abnormal_autonomic_nervous0.86455170
72MP0002398_abnormal_bone_marrow0.85897029
73MP0005389_reproductive_system_phenotype0.83863356
74MP0000689_abnormal_spleen_morphology0.83202817
75MP0003806_abnormal_nucleotide_metabolis0.83187878
76MP0002233_abnormal_nose_morphology0.82997086
77MP0000579_abnormal_nail_morphology0.81603485
78MP0001929_abnormal_gametogenesis0.81538125
79MP0002722_abnormal_immune_system0.81287805
80MP0000653_abnormal_sex_gland0.81194407
81MP0003136_yellow_coat_color0.80169468
82MP0002102_abnormal_ear_morphology0.79315359
83MP0002095_abnormal_skin_pigmentation0.79243486
84MP0002092_abnormal_eye_morphology0.78840033
85MP0008995_early_reproductive_senescence0.78796347
86MP0005075_abnormal_melanosome_morpholog0.78437343
87MP0001119_abnormal_female_reproductive0.76109231
88MP0000428_abnormal_craniofacial_morphol0.75427713
89MP0005384_cellular_phenotype0.75060521
90MP0003787_abnormal_imprinting0.73727769
91MP0000358_abnormal_cell_content/0.72059846
92MP0002796_impaired_skin_barrier0.71964800
93MP0001727_abnormal_embryo_implantation0.71213870
94MP0003950_abnormal_plasma_membrane0.70944265
95MP0010234_abnormal_vibrissa_follicle0.70617856
96MP0000015_abnormal_ear_pigmentation0.69960349
97MP0002653_abnormal_ependyma_morphology0.68729742
98MP0005621_abnormal_cell_physiology0.68566466
99MP0009703_decreased_birth_body0.68416267
100MP0001529_abnormal_vocalization0.68410172
101MP0001881_abnormal_mammary_gland0.68274613
102MP0002009_preneoplasia0.68220579
103MP0005174_abnormal_tail_pigmentation0.67292467
104MP0001188_hyperpigmentation0.67254350
105MP0009672_abnormal_birth_weight0.67012173
106MP0005501_abnormal_skin_physiology0.65625156
107MP0003861_abnormal_nervous_system0.65067071
108MP0003221_abnormal_cardiomyocyte_apopto0.64351531
109MP0002877_abnormal_melanocyte_morpholog0.63840335
110MP0001545_abnormal_hematopoietic_system0.63767052
111MP0005397_hematopoietic_system_phenotyp0.63767052
112MP0004185_abnormal_adipocyte_glucose0.63697058
113MP0002429_abnormal_blood_cell0.62993169
114MP0000647_abnormal_sebaceous_gland0.62809017
115MP0002234_abnormal_pharynx_morphology0.61821060
116MP0000566_synostosis0.61773031
117MP0000627_abnormal_mammary_gland0.60303193
118MP0003699_abnormal_female_reproductive0.60151396
119MP0005395_other_phenotype0.59927929
120MP0005076_abnormal_cell_differentiation0.59871314
121MP0002277_abnormal_respiratory_mucosa0.59640905
122MP0003755_abnormal_palate_morphology0.59164613
123MP0003938_abnormal_ear_development0.57951675
124MP0002254_reproductive_system_inflammat0.57782717
125MP0002697_abnormal_eye_size0.57676049
126MP0005391_vision/eye_phenotype0.56769023
127MP0000858_altered_metastatic_potential0.56274369
128MP0003698_abnormal_male_reproductive0.55887248
129MP0000432_abnormal_head_morphology0.55652109
130MP0001186_pigmentation_phenotype0.55311325
131MP0001919_abnormal_reproductive_system0.54499604
132MP0002075_abnormal_coat/hair_pigmentati0.54472059
133MP0009697_abnormal_copulation0.53980274

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.05765745
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32341964
3Chromsome breakage (HP:0040012)4.29220650
4Breast hypoplasia (HP:0003187)3.93037163
5Reticulocytopenia (HP:0001896)3.86385093
6Meckel diverticulum (HP:0002245)3.57472997
7Abnormality of the preputium (HP:0100587)3.49703968
8Abnormality of chromosome stability (HP:0003220)3.43641224
9Patellar aplasia (HP:0006443)3.40838025
10Abnormality of the ileum (HP:0001549)3.39656840
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.37473483
12Medulloblastoma (HP:0002885)3.28622553
13Abnormality of the labia minora (HP:0012880)3.24052301
14Colon cancer (HP:0003003)3.19050714
15Aplasia/Hypoplasia of the patella (HP:0006498)3.18119682
16Cerebral hypomyelination (HP:0006808)3.05735710
17Oral leukoplakia (HP:0002745)3.03346690
18Abnormality of cells of the erythroid lineage (HP:0012130)2.99832018
19Reduced antithrombin III activity (HP:0001976)2.93032219
20Abnormality of methionine metabolism (HP:0010901)2.93009675
21Absent radius (HP:0003974)2.91612967
22Carpal bone hypoplasia (HP:0001498)2.86320656
23Selective tooth agenesis (HP:0001592)2.83535362
24Microvesicular hepatic steatosis (HP:0001414)2.82513820
25Ependymoma (HP:0002888)2.82157489
26Abnormal number of erythroid precursors (HP:0012131)2.80604663
27Duodenal stenosis (HP:0100867)2.78087387
28Small intestinal stenosis (HP:0012848)2.78087387
29Agnosia (HP:0010524)2.74408729
30Rough bone trabeculation (HP:0100670)2.74318047
31Degeneration of anterior horn cells (HP:0002398)2.74013730
32Abnormality of the anterior horn cell (HP:0006802)2.74013730
33Myelodysplasia (HP:0002863)2.73807338
34Aplasia involving forearm bones (HP:0009822)2.68600263
35Absent forearm bone (HP:0003953)2.68600263
36Absent thumb (HP:0009777)2.68526398
37Impulsivity (HP:0100710)2.67433416
38Increased hepatocellular lipid droplets (HP:0006565)2.66552010
39Aplastic anemia (HP:0001915)2.55532550
40Duplicated collecting system (HP:0000081)2.51892952
41Bone marrow hypocellularity (HP:0005528)2.46766694
4211 pairs of ribs (HP:0000878)2.45572236
43Sloping forehead (HP:0000340)2.43087266
44Premature graying of hair (HP:0002216)2.41854030
45Multiple enchondromatosis (HP:0005701)2.40632588
46Horseshoe kidney (HP:0000085)2.38921547
47Ectopic kidney (HP:0000086)2.38582703
48Abnormality of glycolysis (HP:0004366)2.38388571
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37103052
50Abnormality of the carotid arteries (HP:0005344)2.36768133
51Macrocytic anemia (HP:0001972)2.36377894
52Abnormal number of incisors (HP:0011064)2.34638822
53Lipid accumulation in hepatocytes (HP:0006561)2.33926756
54Triphalangeal thumb (HP:0001199)2.31782602
55Abnormality of the duodenum (HP:0002246)2.30942841
56Increased serum pyruvate (HP:0003542)2.29456408
57Abnormal lung lobation (HP:0002101)2.29240005
58Supernumerary spleens (HP:0009799)2.28140783
59Volvulus (HP:0002580)2.23970995
60Pallor (HP:0000980)2.22673925
61Abnormality of DNA repair (HP:0003254)2.20038298
62Abnormality of the renal collecting system (HP:0004742)2.20024414
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.18899829
64Abnormal protein glycosylation (HP:0012346)2.18323789
65Abnormal glycosylation (HP:0012345)2.18323789
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18323789
67Abnormal protein N-linked glycosylation (HP:0012347)2.18323789
68Abnormality of homocysteine metabolism (HP:0010919)2.16750905
69Homocystinuria (HP:0002156)2.16750905
70Short thumb (HP:0009778)2.15988442
71Rhabdomyosarcoma (HP:0002859)2.15829329
72Neoplasm of the pancreas (HP:0002894)2.14074848
73Megaloblastic anemia (HP:0001889)2.14066564
74Increased nuchal translucency (HP:0010880)2.14005849
75Increased CSF lactate (HP:0002490)2.13243151
76Optic nerve coloboma (HP:0000588)2.12727829
77Acute necrotizing encephalopathy (HP:0006965)2.11187218
78Missing ribs (HP:0000921)2.10642433
79Pancreatic islet-cell hyperplasia (HP:0004510)2.09359953
80Increased serum lactate (HP:0002151)2.07952108
81Methylmalonic acidemia (HP:0002912)2.07756176
82Acute encephalopathy (HP:0006846)2.06893262
83Atresia of the external auditory canal (HP:0000413)2.05421999
84Cellular immunodeficiency (HP:0005374)2.04600136
85Hypoplasia of the pons (HP:0012110)2.04263701
86Tracheoesophageal fistula (HP:0002575)2.04252793
87Cleft eyelid (HP:0000625)2.03188186
88Cortical dysplasia (HP:0002539)2.02692909
89Neoplasm of the colon (HP:0100273)2.02324314
90Neoplasm of the adrenal gland (HP:0100631)2.01847680
91Clubbing of toes (HP:0100760)2.01724085
92Facial hemangioma (HP:0000329)2.01493996
93Embryonal renal neoplasm (HP:0011794)2.00458206
94Nephroblastoma (Wilms tumor) (HP:0002667)2.00289378
95Lymphoma (HP:0002665)1.97914099
96Abnormal mitochondria in muscle tissue (HP:0008316)1.97835016
97Glioma (HP:0009733)1.97205289
98Spastic diplegia (HP:0001264)1.97170168
99Proximal placement of thumb (HP:0009623)1.96539675
100Ureteral duplication (HP:0000073)1.94531098
101Abnormality of the pons (HP:0007361)1.92111400
102Deviation of the thumb (HP:0009603)1.90228716
103Abnormal trabecular bone morphology (HP:0100671)1.88101584
104Pancreatic cysts (HP:0001737)1.87839611
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87746921
106Pancreatic fibrosis (HP:0100732)1.87468684
107Pelvic girdle muscle weakness (HP:0003749)1.85898975
108Abnormality of serum amino acid levels (HP:0003112)1.84886498
109Breast carcinoma (HP:0003002)1.84103936
110Neoplasm of the adrenal cortex (HP:0100641)1.84052033
111Type I transferrin isoform profile (HP:0003642)1.81798376
112Slender long bone (HP:0003100)1.81634138
113Shoulder girdle muscle weakness (HP:0003547)1.81337735
114Secondary amenorrhea (HP:0000869)1.79747688
115Cutaneous melanoma (HP:0012056)1.78354428
116Cafe-au-lait spot (HP:0000957)1.78305403
117Basal cell carcinoma (HP:0002671)1.78296692
118Facial cleft (HP:0002006)1.77960262
119Prominent nose (HP:0000448)1.77745631
120Thrombocytosis (HP:0001894)1.77745109
121Bifid tongue (HP:0010297)1.76348972
122Mitochondrial inheritance (HP:0001427)1.74862580
123Microretrognathia (HP:0000308)1.74559324
124Pancytopenia (HP:0001876)1.74373982
125Breast aplasia (HP:0100783)1.74291282
126Astrocytoma (HP:0009592)1.74192064
127Abnormality of the astrocytes (HP:0100707)1.74192064
128Amaurosis fugax (HP:0100576)1.74006229
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.73666795
130Cerebral edema (HP:0002181)1.73628825
131Arteriovenous malformation (HP:0100026)1.73385100
132Postnatal microcephaly (HP:0005484)1.72428394
133Progressive external ophthalmoplegia (HP:0000590)1.71707718
134Depressed nasal ridge (HP:0000457)1.70365183
135Gonadotropin excess (HP:0000837)1.69153765
136Choanal atresia (HP:0000453)1.69085332
137Abnormalities of placenta or umbilical cord (HP:0001194)1.68994467
138Premature ovarian failure (HP:0008209)1.68295879
139Abnormality of the umbilical cord (HP:0010881)1.68228103
140Abdominal situs inversus (HP:0003363)1.68133858
141Abnormality of abdominal situs (HP:0011620)1.68133858
142Trismus (HP:0000211)1.67911040
143Progressive macrocephaly (HP:0004481)1.65889492
144Microglossia (HP:0000171)1.64491277
145Esophageal atresia (HP:0002032)1.63640797
146Embryonal neoplasm (HP:0002898)1.62051081
147Hepatocellular necrosis (HP:0001404)1.60919086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.73741485
2BUB14.63758064
3CDC73.63121251
4SRPK13.27809904
5EIF2AK13.16061402
6TSSK63.11631067
7VRK22.76339302
8BRSK22.76156940
9STK162.52208572
10TAF12.50886069
11PLK42.44373577
12MKNK12.42031707
13EIF2AK32.40231359
14NEK22.38773190
15NUAK12.26237229
16TTK2.24086900
17PLK12.15307024
18PLK32.12212256
19TRIM282.02874243
20MKNK22.00253518
21NEK11.93751240
22VRK11.92740787
23NME21.90255081
24ACVR1B1.88641535
25AURKB1.82828577
26EPHA21.76559267
27ATR1.75081145
28TLK11.74491296
29BRSK11.68482014
30DYRK31.66750895
31PASK1.64534172
32CDK71.55694819
33ZAK1.46264828
34RPS6KB21.45760470
35CHEK21.39450824
36CCNB11.33508402
37PNCK1.30885032
38CHEK11.30756887
39AKT31.28849946
40TESK21.28154330
41EIF2AK21.17925961
42LATS11.15822633
43RPS6KA41.15020974
44AURKA1.14327694
45BRD41.10649047
46TGFBR11.01898305
47ATM1.00443330
48WNK30.97104591
49STK40.95726883
50SMG10.95427845
51CDK40.93477784
52CDK120.93454194
53MAP3K80.91694347
54CDK20.90651952
55MAP3K100.80859844
56ALK0.79856636
57CSNK2A20.78170186
58CDK10.75299655
59TNIK0.74521417
60FLT30.73393340
61CSNK2A10.72284350
62IRAK30.71087134
63STK100.70082438
64SCYL20.69766042
65BMPR1B0.69467335
66PRKCI0.63786145
67MST40.62915591
68MAP4K20.62520442
69ERBB40.57992580
70PIM10.57015544
71PIM20.54989901
72STK38L0.54973616
73MST1R0.54610346
74YES10.54590508
75PAK10.54199975
76DYRK20.54175721
77RPS6KA50.53029724
78MELK0.52457643
79PAK40.50804464
80CSNK1G10.50763187
81PBK0.49006486
82NME10.48749618
83EEF2K0.48517555
84BRAF0.47754512
85CDK80.46624130
86CSNK1E0.46445620
87DAPK10.45432065
88PDK40.45094200
89PDK30.45094200
90CDK30.43342269
91SIK30.42715483
92STK30.42595822
93PRKDC0.38410215
94CDK90.35528201
95AKT20.35494381
96MAP3K120.35277656
97NEK60.34718804
98TXK0.34567722
99PDK20.32414329
100CDK60.31851835
101PLK20.31814997
102KDR0.29283373
103MAPK140.28699152
104RPS6KB10.28691403
105TEC0.28473189
106CLK10.27446766
107CSNK1A1L0.26276230
108STK390.25814925
109CSNK1D0.25401759
110ERBB30.23546992
111MAPKAPK50.23155411
112IRAK40.22907060
113CSNK1G30.21716153
114TESK10.20504780
115GSK3B0.20425535
116LIMK10.20032739
117LYN0.18525353
118ABL20.18311471
119FGFR10.18027374
120AKT10.17681209
121BCR0.16436724
122MAP4K10.16364083
123CSNK1G20.16178741
124MAPK90.15687114
125NEK90.15525443
126BCKDK0.15460220

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69646903
2Mismatch repair_Homo sapiens_hsa034304.19204897
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02535102
4RNA polymerase_Homo sapiens_hsa030203.68695502
5Spliceosome_Homo sapiens_hsa030403.54359391
6Proteasome_Homo sapiens_hsa030503.43962811
7RNA transport_Homo sapiens_hsa030133.32770757
8Ribosome_Homo sapiens_hsa030103.17509037
9Homologous recombination_Homo sapiens_hsa034403.04998550
10Base excision repair_Homo sapiens_hsa034102.96790917
11Nucleotide excision repair_Homo sapiens_hsa034202.96299230
12Cell cycle_Homo sapiens_hsa041102.70391856
13One carbon pool by folate_Homo sapiens_hsa006702.63332012
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52427829
15Pyrimidine metabolism_Homo sapiens_hsa002402.52245435
16Non-homologous end-joining_Homo sapiens_hsa034502.45386452
17Fanconi anemia pathway_Homo sapiens_hsa034602.43265357
18Basal transcription factors_Homo sapiens_hsa030222.08591432
19RNA degradation_Homo sapiens_hsa030181.97487097
20mRNA surveillance pathway_Homo sapiens_hsa030151.89766648
21p53 signaling pathway_Homo sapiens_hsa041151.55753929
22Purine metabolism_Homo sapiens_hsa002301.42260247
23Pyruvate metabolism_Homo sapiens_hsa006201.40711829
24Propanoate metabolism_Homo sapiens_hsa006401.32617376
25Vitamin B6 metabolism_Homo sapiens_hsa007501.25349389
26Systemic lupus erythematosus_Homo sapiens_hsa053221.24885519
27Epstein-Barr virus infection_Homo sapiens_hsa051691.23623316
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22647779
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16437813
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09505159
31Steroid biosynthesis_Homo sapiens_hsa001001.07764885
32Fatty acid elongation_Homo sapiens_hsa000621.00225311
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96001384
34Oocyte meiosis_Homo sapiens_hsa041140.93284004
35Viral carcinogenesis_Homo sapiens_hsa052030.90834609
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90218682
37Protein export_Homo sapiens_hsa030600.89874451
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86436012
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84711741
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81271302
41Herpes simplex infection_Homo sapiens_hsa051680.80734413
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78946244
43Antigen processing and presentation_Homo sapiens_hsa046120.78831818
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.75604611
45HTLV-I infection_Homo sapiens_hsa051660.69002187
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68957640
47Folate biosynthesis_Homo sapiens_hsa007900.68892581
48Primary immunodeficiency_Homo sapiens_hsa053400.67162191
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.65303511
50MicroRNAs in cancer_Homo sapiens_hsa052060.63427291
51Thyroid cancer_Homo sapiens_hsa052160.63389327
52Pentose phosphate pathway_Homo sapiens_hsa000300.62004296
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.58657341
54Biosynthesis of amino acids_Homo sapiens_hsa012300.57062341
55Lysine degradation_Homo sapiens_hsa003100.56759321
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53366959
57Vitamin digestion and absorption_Homo sapiens_hsa049770.51520293
58Huntingtons disease_Homo sapiens_hsa050160.50371790
59Regulation of autophagy_Homo sapiens_hsa041400.49485215
60Legionellosis_Homo sapiens_hsa051340.48983324
61Selenocompound metabolism_Homo sapiens_hsa004500.48916864
62Alzheimers disease_Homo sapiens_hsa050100.48720944
63Alcoholism_Homo sapiens_hsa050340.48580239
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44323557
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42251563
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41821929
67Hippo signaling pathway_Homo sapiens_hsa043900.41101760
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40586415
69N-Glycan biosynthesis_Homo sapiens_hsa005100.40279046
70Basal cell carcinoma_Homo sapiens_hsa052170.39712403
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39200065
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.37910655
73Small cell lung cancer_Homo sapiens_hsa052220.37771002
74Measles_Homo sapiens_hsa051620.36897616
75Caffeine metabolism_Homo sapiens_hsa002320.36655574
76Arginine and proline metabolism_Homo sapiens_hsa003300.36065901
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34890869
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34846156
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34202800
80TGF-beta signaling pathway_Homo sapiens_hsa043500.32338155
81Colorectal cancer_Homo sapiens_hsa052100.31550683
82Shigellosis_Homo sapiens_hsa051310.31405241
83Glutathione metabolism_Homo sapiens_hsa004800.30644578
84Fatty acid metabolism_Homo sapiens_hsa012120.29876839
85Butanoate metabolism_Homo sapiens_hsa006500.28564386
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27995557
87Apoptosis_Homo sapiens_hsa042100.27722377
88Parkinsons disease_Homo sapiens_hsa050120.27238139
89Hematopoietic cell lineage_Homo sapiens_hsa046400.26516520
90Fatty acid degradation_Homo sapiens_hsa000710.26458248
91Fructose and mannose metabolism_Homo sapiens_hsa000510.25323014
92Hepatitis B_Homo sapiens_hsa051610.25023521
93beta-Alanine metabolism_Homo sapiens_hsa004100.24530148
94Viral myocarditis_Homo sapiens_hsa054160.24397027
95Peroxisome_Homo sapiens_hsa041460.23690527
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22796781
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22523507
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21795434
99Carbon metabolism_Homo sapiens_hsa012000.20719623
100Allograft rejection_Homo sapiens_hsa053300.20690101
101Prostate cancer_Homo sapiens_hsa052150.19896407
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.19823397
103Hedgehog signaling pathway_Homo sapiens_hsa043400.18416253
104Metabolic pathways_Homo sapiens_hsa011000.18274841
105Pathways in cancer_Homo sapiens_hsa052000.18087005
106Sulfur metabolism_Homo sapiens_hsa009200.17824455
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15774121
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15363816
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.15277313
110Sulfur relay system_Homo sapiens_hsa041220.14532135
111Wnt signaling pathway_Homo sapiens_hsa043100.14518555
112Tryptophan metabolism_Homo sapiens_hsa003800.14132216
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13780873
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13679593
115Oxidative phosphorylation_Homo sapiens_hsa001900.13551862
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13445486
117Notch signaling pathway_Homo sapiens_hsa043300.12731392
118Type I diabetes mellitus_Homo sapiens_hsa049400.12653985
119T cell receptor signaling pathway_Homo sapiens_hsa046600.12200751
120Adherens junction_Homo sapiens_hsa045200.11666529
121HIF-1 signaling pathway_Homo sapiens_hsa040660.11296675
122Asthma_Homo sapiens_hsa053100.10476166
123Chronic myeloid leukemia_Homo sapiens_hsa052200.10473566
124Graft-versus-host disease_Homo sapiens_hsa053320.09174213
125Melanoma_Homo sapiens_hsa052180.07956656
126Acute myeloid leukemia_Homo sapiens_hsa052210.07572141

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