NOL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62733774
2vocalization behavior (GO:0071625)5.54698195
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43207157
4neuron cell-cell adhesion (GO:0007158)5.42962039
5regulation of synaptic vesicle exocytosis (GO:2000300)5.20814170
6synaptic vesicle exocytosis (GO:0016079)5.18884737
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17323607
8pyrimidine nucleobase catabolic process (GO:0006208)5.09203413
9regulation of glutamate receptor signaling pathway (GO:1900449)4.94845628
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86389885
11locomotory exploration behavior (GO:0035641)4.80825244
12protein localization to synapse (GO:0035418)4.77125481
13synaptic vesicle maturation (GO:0016188)4.76943381
14glutamate secretion (GO:0014047)4.72365658
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.67126196
16regulation of synaptic vesicle transport (GO:1902803)4.65029549
17nucleobase catabolic process (GO:0046113)4.54019058
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.47152681
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42602805
20synaptic transmission, glutamatergic (GO:0035249)4.13552854
21neuronal action potential propagation (GO:0019227)4.10431801
22presynaptic membrane assembly (GO:0097105)4.10012019
23neurotransmitter-gated ion channel clustering (GO:0072578)4.08046229
24glutamate receptor signaling pathway (GO:0007215)4.07675438
25postsynaptic membrane organization (GO:0001941)4.05488796
26neuron recognition (GO:0008038)4.04080328
27neurotransmitter secretion (GO:0007269)4.04075421
28regulation of neuronal synaptic plasticity (GO:0048168)3.98321396
29exploration behavior (GO:0035640)3.96417785
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93730648
31layer formation in cerebral cortex (GO:0021819)3.91535301
32positive regulation of synapse maturation (GO:0090129)3.87385660
33neuron-neuron synaptic transmission (GO:0007270)3.84666820
34dendritic spine morphogenesis (GO:0060997)3.81784975
35regulation of synapse structural plasticity (GO:0051823)3.78420022
36axonal fasciculation (GO:0007413)3.69958230
37presynaptic membrane organization (GO:0097090)3.67100372
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65956363
39positive regulation of membrane potential (GO:0045838)3.62406599
40gamma-aminobutyric acid transport (GO:0015812)3.55718295
41long-term memory (GO:0007616)3.53408470
42regulation of postsynaptic membrane potential (GO:0060078)3.49152579
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47731641
44proline transport (GO:0015824)3.46859123
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.45906596
46synaptic vesicle endocytosis (GO:0048488)3.45332743
47detection of calcium ion (GO:0005513)3.45177153
48long-term synaptic potentiation (GO:0060291)3.43195993
49regulation of neurotransmitter secretion (GO:0046928)3.42765306
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41708131
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41646325
52behavioral response to nicotine (GO:0035095)3.41032046
53regulation of synaptic plasticity (GO:0048167)3.34173973
54glycosphingolipid biosynthetic process (GO:0006688)3.33535630
55regulation of dendritic spine morphogenesis (GO:0061001)3.32739659
56dendrite morphogenesis (GO:0048813)3.31820565
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29436915
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.29432981
59activation of protein kinase A activity (GO:0034199)3.25415718
60neurotransmitter transport (GO:0006836)3.24454970
61regulation of synapse maturation (GO:0090128)3.22319727
62synapse assembly (GO:0007416)3.21826612
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20338586
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19249695
65transmission of nerve impulse (GO:0019226)3.18967351
66negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17794014
67cerebellar granule cell differentiation (GO:0021707)3.16344514
68auditory behavior (GO:0031223)3.14685049
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14573677
70establishment of mitochondrion localization (GO:0051654)3.14372445
71central nervous system projection neuron axonogenesis (GO:0021952)3.13183479
72calcium ion-dependent exocytosis (GO:0017156)3.13007824
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12735149
74protein localization to cilium (GO:0061512)3.12344945
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.09608617
76regulation of vesicle fusion (GO:0031338)3.07276669
77regulation of neurotransmitter transport (GO:0051588)3.06584737
78innervation (GO:0060384)3.05800735
79protein polyglutamylation (GO:0018095)3.05738486
80positive regulation of neurotransmitter secretion (GO:0001956)3.04341957
81membrane depolarization (GO:0051899)3.02590192
82startle response (GO:0001964)3.00667281
83membrane depolarization during action potential (GO:0086010)2.99438665
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98471838
85response to auditory stimulus (GO:0010996)2.97509662
86mechanosensory behavior (GO:0007638)2.96971184
87dendritic spine organization (GO:0097061)2.95783317
88social behavior (GO:0035176)2.94798339
89intraspecies interaction between organisms (GO:0051703)2.94798339
90glycerophospholipid catabolic process (GO:0046475)2.93202498
91positive regulation of synapse assembly (GO:0051965)2.92106602
92neurofilament cytoskeleton organization (GO:0060052)2.92059724
93regulation of neurotransmitter levels (GO:0001505)2.91674848
94learning (GO:0007612)2.90242555
95regulation of respiratory system process (GO:0044065)2.87997963
96synapse organization (GO:0050808)2.87050539
97vesicle transport along microtubule (GO:0047496)2.86040964
98synaptic transmission (GO:0007268)2.85951189
99regulation of dendritic spine development (GO:0060998)2.85087122
100behavioral fear response (GO:0001662)2.84607443
101behavioral defense response (GO:0002209)2.84607443
102regulation of synaptic transmission (GO:0050804)2.83379503
103chemosensory behavior (GO:0007635)2.83230392
104cerebellar Purkinje cell differentiation (GO:0021702)2.82707485
105hippocampus development (GO:0021766)2.81374960
106positive regulation of synaptic transmission (GO:0050806)2.81218484
107neuronal ion channel clustering (GO:0045161)2.80943624
108synaptic vesicle transport (GO:0048489)2.80367131
109establishment of synaptic vesicle localization (GO:0097480)2.80367131
110membrane hyperpolarization (GO:0060081)2.80292610
111cell migration in hindbrain (GO:0021535)2.79848349
112insulin secretion (GO:0030073)2.78767917
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.77533260
114nonmotile primary cilium assembly (GO:0035058)2.76856046
115adult walking behavior (GO:0007628)2.75036278
116negative regulation of dendrite development (GO:2000171)2.73120331
117neuromuscular synaptic transmission (GO:0007274)2.73033130
118neuronal action potential (GO:0019228)2.71731677
119reflex (GO:0060004)2.68087082
120adult behavior (GO:0030534)2.63246538
121response to dietary excess (GO:0002021)2.60736751
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57587761
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57028045
124olfactory bulb development (GO:0021772)2.56534837
125calcium ion import (GO:0070509)2.55776768
126calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53798358
127central nervous system neuron axonogenesis (GO:0021955)2.52589694
128signal release (GO:0023061)2.51881677
129retinal ganglion cell axon guidance (GO:0031290)2.50691740
130cAMP-mediated signaling (GO:0019933)2.50183178
131brain morphogenesis (GO:0048854)2.49700972
132serotonin metabolic process (GO:0042428)2.48910209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29813716
2GBX2_23144817_ChIP-Seq_PC3_Human3.74672039
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92518534
4REST_21632747_ChIP-Seq_MESCs_Mouse2.76369130
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76092379
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71746575
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48983994
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42642976
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41120891
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41120891
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40755223
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36358689
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32617119
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30959401
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.23900158
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23139746
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21462599
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.19776561
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18619772
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.17655968
21DROSHA_22980978_ChIP-Seq_HELA_Human2.16897342
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15791629
23* EED_16625203_ChIP-ChIP_MESCs_Mouse2.10597577
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09659659
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04419461
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03954488
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00803300
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99645775
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93247093
30TAF15_26573619_Chip-Seq_HEK293_Human1.88382047
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79189581
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74299511
33* CBX2_27304074_Chip-Seq_ESCs_Mouse1.70298643
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70138152
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.70028740
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69397331
37ZNF274_21170338_ChIP-Seq_K562_Hela1.68868987
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63653110
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62785646
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61940326
41* P300_19829295_ChIP-Seq_ESCs_Human1.55435169
42IGF1R_20145208_ChIP-Seq_DFB_Human1.49337317
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.47055941
44AR_21572438_ChIP-Seq_LNCaP_Human1.46318436
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43689559
46RNF2_27304074_Chip-Seq_NSC_Mouse1.42575629
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42450332
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.39329148
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.39057634
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38231243
51CBP_20019798_ChIP-Seq_JUKART_Human1.38231243
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37992903
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36250454
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36225245
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34404153
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34370529
57EWS_26573619_Chip-Seq_HEK293_Human1.34231256
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34128101
59* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33158602
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33048051
61AR_25329375_ChIP-Seq_VCAP_Human1.32749555
62VDR_22108803_ChIP-Seq_LS180_Human1.30210097
63* STAT3_23295773_ChIP-Seq_U87_Human1.29923460
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.24369803
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22413832
66BCAT_22108803_ChIP-Seq_LS180_Human1.20988842
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20680073
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20318183
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19947915
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.19166792
71FUS_26573619_Chip-Seq_HEK293_Human1.17458381
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.15512355
73* TCF4_23295773_ChIP-Seq_U87_Human1.15393695
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14750133
75* AR_19668381_ChIP-Seq_PC3_Human1.14310964
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14098058
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13266165
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12435009
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.12124451
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11281726
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.10735309
82RUNX2_22187159_ChIP-Seq_PCA_Human1.10073995
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.09591691
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09224986
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08387916
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07409984
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07409984
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06532898
89* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06196136
90* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05804296
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05554670
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03094715
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02382859
94* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02360375
95AHR_22903824_ChIP-Seq_MCF-7_Human1.01701928
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01050612
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01045150
98ER_23166858_ChIP-Seq_MCF-7_Human1.00496544
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00386277
100TP53_22573176_ChIP-Seq_HFKS_Human1.00024051
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99708752
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99257376
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98931887
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98371880
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.98368674
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98232049
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97990055
108TCF4_22108803_ChIP-Seq_LS180_Human0.97216460
109KDM2B_26808549_Chip-Seq_REH_Human0.96396089
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96212312
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96175189
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95780076
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95588594
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93479471
115P53_22387025_ChIP-Seq_ESCs_Mouse0.92773980
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.92566345
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.92121328
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.91919405
119JUN_21703547_ChIP-Seq_K562_Human0.91436139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.59434809
2MP0003880_abnormal_central_pattern4.38905774
3MP0003635_abnormal_synaptic_transmissio3.89028065
4MP0004270_analgesia3.69487012
5MP0002063_abnormal_learning/memory/cond3.22630658
6MP0009745_abnormal_behavioral_response3.11291359
7MP0002064_seizures2.83472545
8MP0009046_muscle_twitch2.78306579
9MP0002572_abnormal_emotion/affect_behav2.75301647
10MP0005423_abnormal_somatic_nervous2.65735644
11MP0001968_abnormal_touch/_nociception2.65316344
12MP0002734_abnormal_mechanical_nocicepti2.49097302
13MP0001486_abnormal_startle_reflex2.40767927
14MP0009780_abnormal_chondrocyte_physiolo2.35539724
15MP0002272_abnormal_nervous_system2.32627221
16MP0005646_abnormal_pituitary_gland2.26092297
17MP0005645_abnormal_hypothalamus_physiol2.15554952
18MP0000778_abnormal_nervous_system2.10664161
19MP0003787_abnormal_imprinting2.09218538
20MP0002909_abnormal_adrenal_gland2.04635937
21MP0002822_catalepsy2.04240235
22MP0001984_abnormal_olfaction2.00967400
23MP0002184_abnormal_innervation2.00292270
24MP0001501_abnormal_sleep_pattern1.99642389
25MP0002735_abnormal_chemical_nociception1.99124365
26MP0002736_abnormal_nociception_after1.97082379
27MP0002557_abnormal_social/conspecific_i1.95164407
28MP0002733_abnormal_thermal_nociception1.91841674
29MP0002102_abnormal_ear_morphology1.91767665
30MP0002067_abnormal_sensory_capabilities1.87295282
31MP0001440_abnormal_grooming_behavior1.85157799
32MP0004811_abnormal_neuron_physiology1.77563065
33MP0001970_abnormal_pain_threshold1.76207245
34MP0001188_hyperpigmentation1.73205686
35MP0006276_abnormal_autonomic_nervous1.72604073
36MP0008569_lethality_at_weaning1.68360215
37MP0004924_abnormal_behavior1.58757179
38MP0005386_behavior/neurological_phenoty1.58757179
39MP0000955_abnormal_spinal_cord1.54553125
40MP0003879_abnormal_hair_cell1.54347845
41MP0010386_abnormal_urinary_bladder1.51552875
42MP0002882_abnormal_neuron_morphology1.45898715
43MP0004858_abnormal_nervous_system1.45543067
44MP0001502_abnormal_circadian_rhythm1.45311112
45MP0003122_maternal_imprinting1.40877677
46MP0003329_amyloid_beta_deposits1.37097898
47MP0005499_abnormal_olfactory_system1.36429320
48MP0005394_taste/olfaction_phenotype1.36429320
49MP0002066_abnormal_motor_capabilities/c1.34143678
50MP0000631_abnormal_neuroendocrine_gland1.31392475
51MP0004885_abnormal_endolymph1.29668020
52MP0002837_dystrophic_cardiac_calcinosis1.28028499
53MP0001529_abnormal_vocalization1.27044141
54MP0002638_abnormal_pupillary_reflex1.23902616
55MP0002152_abnormal_brain_morphology1.21710432
56MP0003195_calcinosis1.21644929
57MP0003283_abnormal_digestive_organ1.20710433
58MP0000013_abnormal_adipose_tissue1.19761097
59MP0006292_abnormal_olfactory_placode1.18292089
60MP0001986_abnormal_taste_sensitivity1.18119047
61MP0004133_heterotaxia1.14062182
62MP0003633_abnormal_nervous_system1.13891355
63MP0002876_abnormal_thyroid_physiology1.08405668
64MP0002069_abnormal_eating/drinking_beha1.04120394
65MP0004043_abnormal_pH_regulation1.02901791
66MP0000569_abnormal_digit_pigmentation1.02251064
67MP0004742_abnormal_vestibular_system0.99649721
68MP0004142_abnormal_muscle_tone0.98307180
69MP0003123_paternal_imprinting0.97497872
70MP0003183_abnormal_peptide_metabolism0.97097278
71MP0005551_abnormal_eye_electrophysiolog0.96747343
72MP0003631_nervous_system_phenotype0.93403135
73MP0008789_abnormal_olfactory_epithelium0.92492187
74MP0008872_abnormal_physiological_respon0.92142007
75MP0001905_abnormal_dopamine_level0.90139182
76MP0004085_abnormal_heartbeat0.89672013
77MP0003119_abnormal_digestive_system0.88493433
78MP0006072_abnormal_retinal_apoptosis0.87928958
79MP0001963_abnormal_hearing_physiology0.87070455
80MP0005379_endocrine/exocrine_gland_phen0.86911813
81MP0002234_abnormal_pharynx_morphology0.85256176
82MP0002229_neurodegeneration0.84742762
83MP0005535_abnormal_body_temperature0.83785578
84MP0002693_abnormal_pancreas_physiology0.82913271
85MP0002752_abnormal_somatic_nervous0.81488092
86MP0001177_atelectasis0.80385627
87MP0001944_abnormal_pancreas_morphology0.78720274
88MP0005410_abnormal_fertilization0.77204038
89MP0003861_abnormal_nervous_system0.76733378
90MP0002163_abnormal_gland_morphology0.76247136
91MP0002078_abnormal_glucose_homeostasis0.75435464
92MP0000049_abnormal_middle_ear0.75244592
93MP0004145_abnormal_muscle_electrophysio0.73892823
94MP0003121_genomic_imprinting0.73784830
95MP0003634_abnormal_glial_cell0.72900487
96MP0005084_abnormal_gallbladder_morpholo0.72458601
97MP0005448_abnormal_energy_balance0.71316076
98MP0003011_delayed_dark_adaptation0.71247953
99MP0002090_abnormal_vision0.70701717
100MP0002653_abnormal_ependyma_morphology0.70262155
101MP0003890_abnormal_embryonic-extraembry0.70077140
102MP0000678_abnormal_parathyroid_gland0.66861666
103MP0005187_abnormal_penis_morphology0.66636849
104MP0001485_abnormal_pinna_reflex0.65982458
105MP0001664_abnormal_digestion0.65306541
106MP0008961_abnormal_basal_metabolism0.64459644
107MP0000026_abnormal_inner_ear0.62596978
108MP0004215_abnormal_myocardial_fiber0.61980465
109MP0002751_abnormal_autonomic_nervous0.61874522
110MP0008877_abnormal_DNA_methylation0.61749888
111MP0003137_abnormal_impulse_conducting0.60878417
112MP0000751_myopathy0.59204318
113MP0001943_abnormal_respiration0.59203932
114MP0005253_abnormal_eye_physiology0.59141102
115MP0003698_abnormal_male_reproductive0.58032620

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.68644256
2Focal seizures (HP:0007359)5.00828689
3Myokymia (HP:0002411)4.79963723
4Epileptic encephalopathy (HP:0200134)4.76689801
5Visual hallucinations (HP:0002367)4.62059870
6Atonic seizures (HP:0010819)4.27273060
7Febrile seizures (HP:0002373)4.25925068
8Hyperventilation (HP:0002883)4.16341638
9Progressive cerebellar ataxia (HP:0002073)3.85998555
10Absence seizures (HP:0002121)3.75027818
11Dialeptic seizures (HP:0011146)3.51703564
12Broad-based gait (HP:0002136)3.44225602
13Generalized tonic-clonic seizures (HP:0002069)3.22765962
14Poor eye contact (HP:0000817)3.21196926
15Amblyopia (HP:0000646)3.20763481
16Epileptiform EEG discharges (HP:0011182)3.11578273
17Drooling (HP:0002307)3.07237238
18Excessive salivation (HP:0003781)3.07237238
19EEG with generalized epileptiform discharges (HP:0011198)3.00449605
20Hypothermia (HP:0002045)2.90004458
21Truncal ataxia (HP:0002078)2.88468235
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.88260726
23Hypsarrhythmia (HP:0002521)2.87442084
24Intestinal atresia (HP:0011100)2.85290613
25Gaze-evoked nystagmus (HP:0000640)2.84390006
26Depression (HP:0000716)2.82007679
27Impaired vibration sensation in the lower limbs (HP:0002166)2.78701128
28Impaired social interactions (HP:0000735)2.74425193
29Abnormal social behavior (HP:0012433)2.74425193
30Abnormality of the labia minora (HP:0012880)2.72926862
31Agitation (HP:0000713)2.65910958
32Ketoacidosis (HP:0001993)2.65108656
33Action tremor (HP:0002345)2.63134351
34Absent speech (HP:0001344)2.63025182
35Protruding tongue (HP:0010808)2.62856362
36Progressive inability to walk (HP:0002505)2.62658730
37Megalencephaly (HP:0001355)2.59801328
38Supranuclear gaze palsy (HP:0000605)2.59710893
39Limb dystonia (HP:0002451)2.59092853
40Gait imbalance (HP:0002141)2.58877655
41Ankle clonus (HP:0011448)2.57527992
42Anxiety (HP:0000739)2.57074878
43Nephronophthisis (HP:0000090)2.57046133
44Papilledema (HP:0001085)2.52181113
45Urinary bladder sphincter dysfunction (HP:0002839)2.49399192
46Impaired smooth pursuit (HP:0007772)2.49170354
47Pachygyria (HP:0001302)2.48172550
48Stereotypic behavior (HP:0000733)2.48106188
49Abnormal eating behavior (HP:0100738)2.45986318
50Hepatoblastoma (HP:0002884)2.45881833
51Molar tooth sign on MRI (HP:0002419)2.44447021
52Abnormality of midbrain morphology (HP:0002418)2.44447021
53Dysdiadochokinesis (HP:0002075)2.42284285
54Inability to walk (HP:0002540)2.37782628
55Muscular hypotonia of the trunk (HP:0008936)2.37483947
56Genetic anticipation (HP:0003743)2.36238884
57Hemiparesis (HP:0001269)2.35983858
58Medial flaring of the eyebrow (HP:0010747)2.32316116
59Hypoglycemic seizures (HP:0002173)2.31765183
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.29795686
61Absent/shortened dynein arms (HP:0200106)2.29795686
62Hyperinsulinemic hypoglycemia (HP:0000825)2.26705923
63Hypoglycemic coma (HP:0001325)2.25213159
64Blue irides (HP:0000635)2.21938627
65Dysmetria (HP:0001310)2.21230663
66Congenital primary aphakia (HP:0007707)2.18394942
67Spastic tetraplegia (HP:0002510)2.17651147
68Pancreatic fibrosis (HP:0100732)2.17195403
69Fetal akinesia sequence (HP:0001989)2.17002973
70Mutism (HP:0002300)2.15267201
71Type II lissencephaly (HP:0007260)2.13861816
72Polyphagia (HP:0002591)2.13709529
73Failure to thrive in infancy (HP:0001531)2.13104975
74Abnormality of ocular smooth pursuit (HP:0000617)2.12757202
75Thickened helices (HP:0000391)2.11346999
76Amyotrophic lateral sclerosis (HP:0007354)2.10380491
77Chronic hepatic failure (HP:0100626)2.10277844
78Pancreatic cysts (HP:0001737)2.09197161
79Abnormality of salivation (HP:0100755)2.08893690
80Urinary urgency (HP:0000012)2.06850574
81Pheochromocytoma (HP:0002666)2.06693579
82Abnormality of the lower motor neuron (HP:0002366)2.06622023
83Oligodactyly (hands) (HP:0001180)2.05446118
84Esotropia (HP:0000565)2.04819252
85Postural instability (HP:0002172)2.03996350
86Nephrogenic diabetes insipidus (HP:0009806)2.03521624
87Spastic gait (HP:0002064)2.02342192
88Abnormality of the renal medulla (HP:0100957)2.00953126
89Specific learning disability (HP:0001328)1.97827147
90Retinal dysplasia (HP:0007973)1.97535768
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97247816
92Bradykinesia (HP:0002067)1.97241537
93Abnormality of the metopic suture (HP:0005556)1.95534183
94Double outlet right ventricle (HP:0001719)1.95396993
95Congenital malformation of the right heart (HP:0011723)1.95396993
96Poor coordination (HP:0002370)1.94874836
97Poor suck (HP:0002033)1.94795710
98Insidious onset (HP:0003587)1.94655685
99Termporal pattern (HP:0011008)1.94655685
100Absent eyebrow (HP:0002223)1.93580132
101Shoulder girdle muscle weakness (HP:0003547)1.91785747
102Lissencephaly (HP:0001339)1.91416109
103Focal dystonia (HP:0004373)1.88661718
104Generalized hypopigmentation of hair (HP:0011358)1.88205001
105Intention tremor (HP:0002080)1.86375243
106Gait ataxia (HP:0002066)1.86351224
107Gastroesophageal reflux (HP:0002020)1.86223648
108Widely spaced teeth (HP:0000687)1.86066851
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.85908066
110Abnormality of the corticospinal tract (HP:0002492)1.85729172
111Abnormality of binocular vision (HP:0011514)1.85148640
112Diplopia (HP:0000651)1.85148640
113Congenital stationary night blindness (HP:0007642)1.85052681
114Bony spicule pigmentary retinopathy (HP:0007737)1.84285517
115Ketosis (HP:0001946)1.84196949
116Scanning speech (HP:0002168)1.83592539
117Cerebral inclusion bodies (HP:0100314)1.83488011
118Anosmia (HP:0000458)1.83262588
119True hermaphroditism (HP:0010459)1.82783044
120Genital tract atresia (HP:0001827)1.81430035
121Neurofibrillary tangles (HP:0002185)1.79630292
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.79621147
123Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79621147
124Impaired vibratory sensation (HP:0002495)1.78922747
125Vaginal atresia (HP:0000148)1.78752684
126Abnormal ciliary motility (HP:0012262)1.78644954
127Abnormal respiratory motile cilium physiology (HP:0012261)1.78165997
128Obstructive sleep apnea (HP:0002870)1.77652800
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77365556
130Hypoplasia of the brainstem (HP:0002365)1.77365556
131Torticollis (HP:0000473)1.76812625
132Generalized myoclonic seizures (HP:0002123)1.76065824
133Hyperthyroidism (HP:0000836)1.75547455
134Status epilepticus (HP:0002133)1.74856704
135Late onset (HP:0003584)1.74300826
136Insulin-resistant diabetes mellitus (HP:0000831)1.73909670
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71905419
138Prolonged QT interval (HP:0001657)1.69795333
139Labial hypoplasia (HP:0000066)1.69654063
140Abolished electroretinogram (ERG) (HP:0000550)1.68240933
141Abnormality of the renal cortex (HP:0011035)1.67295822
142Polydipsia (HP:0001959)1.64695855
143Abnormal drinking behavior (HP:0030082)1.64695855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.05246067
2EPHA43.91179051
3MARK13.86660457
4CASK3.26199422
5MAP3K43.06075712
6MAP2K72.90969655
7MAP3K92.89719682
8MAP4K22.84847953
9DAPK22.47751545
10PRKD32.40974630
11MINK12.21744122
12NTRK22.17130836
13INSRR1.95637148
14PAK61.91769127
15AKT31.88299971
16MAP2K41.82589272
17MAPK131.80867606
18MAP3K121.78606860
19PRPF4B1.73510930
20CSNK1G31.69645168
21DAPK11.66224314
22TRIM281.65127143
23PLK21.63163088
24KSR11.62831565
25RIPK41.49774577
26CSNK1G11.48523350
27TNIK1.46785596
28CCNB11.46537041
29CDK51.46146666
30KSR21.41251771
31CSNK1A1L1.40050332
32PNCK1.38876895
33UHMK11.38583372
34SIK21.36931942
35CAMKK11.31960614
36NTRK11.30465755
37SGK2231.25113086
38SGK4941.25113086
39PRKCG1.22036746
40CDK191.19889676
41BMPR21.19684991
42MAP3K21.18893498
43SGK21.18624043
44EPHA31.18605697
45FGFR21.15071886
46GRK51.11636696
47GRK11.10971804
48ERBB31.08548316
49CAMKK21.07874596
50ARAF1.03725596
51CAMK2A0.98277700
52ADRBK20.97027251
53WNK30.96965826
54BRAF0.90637597
55CAMK2B0.84127973
56PHKG20.83221871
57PHKG10.83221871
58TYRO30.82517289
59SGK30.82051867
60DYRK1A0.81539304
61PRKCH0.80661673
62STK380.78519549
63PTK2B0.76024245
64CDK180.75309969
65FES0.72243839
66SGK10.71516213
67PAK30.70826516
68CDK150.70172209
69BCR0.70000107
70STK110.69447413
71CDK140.68612483
72SIK30.68595770
73CSNK1G20.67624107
74MARK20.66743772
75CAMK10.66729065
76DYRK20.64002234
77PRKCE0.63878488
78ACVR1B0.60852016
79TAOK10.59977159
80RET0.59637255
81CDK11A0.59415012
82MAP3K60.59112938
83OXSR10.58491649
84STK38L0.57255547
85PRKAA10.55324528
86PINK10.54702217
87PRKCZ0.54640121
88CSNK1A10.53788594
89MAP3K10.53447452
90NUAK10.53327090
91MAP3K130.52839156
92CSNK1D0.52167194
93DYRK30.51485339
94MAP2K60.50989000
95RAF10.49798808
96CDC42BPA0.47505917
97RPS6KA20.46335489
98HIPK20.45562329
99RPS6KA30.43762592
100WNK40.43512782
101CAMK40.42399748
102CAMK2D0.41698123
103CSNK1E0.41282603
104PDK10.37635433
105MAPK100.37137015
106CAMK1G0.36330379
107PRKACB0.36169205
108STK390.35784152
109RPS6KA40.35436039
110FRK0.34461545
111PDPK10.33978073
112MAP2K10.33918009
113PKN10.32401097
114PRKCB0.32322899
115CAMK2G0.32257322
116TNK20.32043559
117PRKACA0.30416969
118PRKG10.30146724
119CDK30.29346469
120FYN0.28772790
121GSK3B0.28734201
122FER0.28557794
123PRKCA0.27657033
124ADRBK10.27091009
125DYRK1B0.26874376
126CAMK1D0.26297420
127BMPR1B0.26272819
128BRSK10.25901357

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67369388
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19621640
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78402579
4Olfactory transduction_Homo sapiens_hsa047402.73783646
5GABAergic synapse_Homo sapiens_hsa047272.71769136
6Circadian entrainment_Homo sapiens_hsa047132.70791008
7Long-term potentiation_Homo sapiens_hsa047202.62578119
8Morphine addiction_Homo sapiens_hsa050322.59095085
9Glutamatergic synapse_Homo sapiens_hsa047242.56123232
10Amphetamine addiction_Homo sapiens_hsa050312.54506110
11Insulin secretion_Homo sapiens_hsa049112.51419323
12Dopaminergic synapse_Homo sapiens_hsa047282.27690373
13Butanoate metabolism_Homo sapiens_hsa006502.13273901
14Taste transduction_Homo sapiens_hsa047422.04907236
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02369291
16Salivary secretion_Homo sapiens_hsa049701.91055662
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90959891
18Cholinergic synapse_Homo sapiens_hsa047251.90274078
19Serotonergic synapse_Homo sapiens_hsa047261.89697973
20Cocaine addiction_Homo sapiens_hsa050301.82924271
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75748184
22Collecting duct acid secretion_Homo sapiens_hsa049661.70879651
23Renin secretion_Homo sapiens_hsa049241.67821954
24Long-term depression_Homo sapiens_hsa047301.66643505
25Gastric acid secretion_Homo sapiens_hsa049711.65503615
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65481867
27Oxytocin signaling pathway_Homo sapiens_hsa049211.54473891
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52472888
29Type II diabetes mellitus_Homo sapiens_hsa049301.49243722
30Protein export_Homo sapiens_hsa030601.47106760
31Calcium signaling pathway_Homo sapiens_hsa040201.45789907
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43553626
33Gap junction_Homo sapiens_hsa045401.34566035
34GnRH signaling pathway_Homo sapiens_hsa049121.34546764
35Vibrio cholerae infection_Homo sapiens_hsa051101.32449901
36cAMP signaling pathway_Homo sapiens_hsa040241.21066473
37Sulfur metabolism_Homo sapiens_hsa009201.18887296
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18677876
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.18558700
40Estrogen signaling pathway_Homo sapiens_hsa049151.18315409
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18048503
42Axon guidance_Homo sapiens_hsa043601.14580028
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14574709
44Oxidative phosphorylation_Homo sapiens_hsa001901.09232826
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08949273
46Glioma_Homo sapiens_hsa052141.07479105
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05948714
48ErbB signaling pathway_Homo sapiens_hsa040121.03317258
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02764323
50Type I diabetes mellitus_Homo sapiens_hsa049401.02267466
51Melanogenesis_Homo sapiens_hsa049161.01207952
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95988658
53Phototransduction_Homo sapiens_hsa047440.94453989
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.90575471
55Pancreatic secretion_Homo sapiens_hsa049720.89452050
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84684001
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83511947
58Oocyte meiosis_Homo sapiens_hsa041140.80188988
59Cardiac muscle contraction_Homo sapiens_hsa042600.79404099
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78712859
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78636306
62Dorso-ventral axis formation_Homo sapiens_hsa043200.76448132
63Alcoholism_Homo sapiens_hsa050340.76096745
64Glucagon signaling pathway_Homo sapiens_hsa049220.75943360
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73543426
66Thyroid hormone synthesis_Homo sapiens_hsa049180.73499023
67MAPK signaling pathway_Homo sapiens_hsa040100.73260809
68Tryptophan metabolism_Homo sapiens_hsa003800.71759738
69Vitamin B6 metabolism_Homo sapiens_hsa007500.71400975
70Circadian rhythm_Homo sapiens_hsa047100.68521333
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67904752
72Parkinsons disease_Homo sapiens_hsa050120.67122688
73Steroid biosynthesis_Homo sapiens_hsa001000.66563745
74Ether lipid metabolism_Homo sapiens_hsa005650.66536360
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65927991
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65694840
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.65033205
78beta-Alanine metabolism_Homo sapiens_hsa004100.64861111
79Choline metabolism in cancer_Homo sapiens_hsa052310.64396014
80Endometrial cancer_Homo sapiens_hsa052130.63754950
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.62049552
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61758175
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61116896
84Dilated cardiomyopathy_Homo sapiens_hsa054140.59386056
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59173824
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57254854
87Wnt signaling pathway_Homo sapiens_hsa043100.56511040
88Ras signaling pathway_Homo sapiens_hsa040140.56507000
89Fatty acid metabolism_Homo sapiens_hsa012120.56488809
90Fatty acid elongation_Homo sapiens_hsa000620.56468772
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53274030
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52306605
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51554926
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49083766
95Prion diseases_Homo sapiens_hsa050200.48034822
96mTOR signaling pathway_Homo sapiens_hsa041500.47956700
97ABC transporters_Homo sapiens_hsa020100.47494706
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47071934
99VEGF signaling pathway_Homo sapiens_hsa043700.47005833
100Insulin signaling pathway_Homo sapiens_hsa049100.46340931
101Rap1 signaling pathway_Homo sapiens_hsa040150.46198484
102Peroxisome_Homo sapiens_hsa041460.46171403
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44639303
104Inositol phosphate metabolism_Homo sapiens_hsa005620.44505492
105Basal transcription factors_Homo sapiens_hsa030220.43727849
106Folate biosynthesis_Homo sapiens_hsa007900.43355088
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42915095
108Renal cell carcinoma_Homo sapiens_hsa052110.42665751
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42413654
110Propanoate metabolism_Homo sapiens_hsa006400.41860830
111Selenocompound metabolism_Homo sapiens_hsa004500.41824378
112Prolactin signaling pathway_Homo sapiens_hsa049170.40805035
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.40104654
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.39610227
115Huntingtons disease_Homo sapiens_hsa050160.38339032
116Linoleic acid metabolism_Homo sapiens_hsa005910.37817787
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37797063
118Colorectal cancer_Homo sapiens_hsa052100.37404324
119Non-small cell lung cancer_Homo sapiens_hsa052230.37145418
120Fatty acid biosynthesis_Homo sapiens_hsa000610.36336242
121Sphingolipid metabolism_Homo sapiens_hsa006000.35326713
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35112702
123Alzheimers disease_Homo sapiens_hsa050100.34529795
124Endocytosis_Homo sapiens_hsa041440.34022833
125AMPK signaling pathway_Homo sapiens_hsa041520.31766083
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30312528
127Chemokine signaling pathway_Homo sapiens_hsa040620.27914363
128Regulation of autophagy_Homo sapiens_hsa041400.26116063
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25668902
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25410660
131Hedgehog signaling pathway_Homo sapiens_hsa043400.25253233
132African trypanosomiasis_Homo sapiens_hsa051430.23462074
133FoxO signaling pathway_Homo sapiens_hsa040680.22105097

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