NOL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational termination (GO:0006449)5.77017939
2pre-miRNA processing (GO:0031054)5.51561719
3Golgi transport vesicle coating (GO:0048200)5.28623910
4COPI coating of Golgi vesicle (GO:0048205)5.28623910
5regulation of translational fidelity (GO:0006450)4.90512340
6peptidyl-arginine omega-N-methylation (GO:0035247)4.40641023
7nuclear pore organization (GO:0006999)4.37072634
8folic acid-containing compound biosynthetic process (GO:0009396)4.32765114
9DNA unwinding involved in DNA replication (GO:0006268)4.29838288
10proline biosynthetic process (GO:0006561)4.23047258
11nuclear pore complex assembly (GO:0051292)4.22311871
12peptidyl-arginine N-methylation (GO:0035246)4.18519048
13peptidyl-arginine methylation (GO:0018216)4.18519048
14IMP biosynthetic process (GO:0006188)4.13120635
15negative regulation of histone methylation (GO:0031061)4.07603163
16heterochromatin organization (GO:0070828)4.06362353
17mitotic chromosome condensation (GO:0007076)4.03382885
18hemidesmosome assembly (GO:0031581)4.02904299
19regulation of posttranscriptional gene silencing (GO:0060147)4.01032575
20regulation of gene silencing by miRNA (GO:0060964)4.01032575
21regulation of gene silencing by RNA (GO:0060966)4.01032575
22mitotic nuclear envelope disassembly (GO:0007077)3.96947845
23spliceosomal tri-snRNP complex assembly (GO:0000244)3.94467149
24nuclear envelope disassembly (GO:0051081)3.88316571
25membrane disassembly (GO:0030397)3.88316571
26protein localization to kinetochore (GO:0034501)3.88067701
27cell-substrate adherens junction assembly (GO:0007045)3.82932744
28focal adhesion assembly (GO:0048041)3.82932744
29histone H4-K12 acetylation (GO:0043983)3.81160740
30cell-substrate junction assembly (GO:0007044)3.79213449
31cellular protein complex localization (GO:0034629)3.77564450
32histone arginine methylation (GO:0034969)3.75397759
33nucleobase biosynthetic process (GO:0046112)3.73343827
34activation of Rac GTPase activity (GO:0032863)3.67982496
35protein localization to endosome (GO:0036010)3.61324713
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52260747
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49737462
38mitotic G1 DNA damage checkpoint (GO:0031571)3.46919899
39IMP metabolic process (GO:0046040)3.46653737
40synaptic vesicle maturation (GO:0016188)3.44754854
41intracellular estrogen receptor signaling pathway (GO:0030520)3.44183295
42DNA duplex unwinding (GO:0032508)3.42563281
43DNA geometric change (GO:0032392)3.39287670
44peptidyl-lysine dimethylation (GO:0018027)3.37571602
45apoptotic process involved in morphogenesis (GO:0060561)3.29624898
46glucocorticoid receptor signaling pathway (GO:0042921)3.27117132
47pentose-phosphate shunt (GO:0006098)3.23186394
48regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22921599
49DNA replication-dependent nucleosome assembly (GO:0006335)3.22151358
50DNA replication-dependent nucleosome organization (GO:0034723)3.22151358
51nuclear envelope organization (GO:0006998)3.21742627
52regulation of NFAT protein import into nucleus (GO:0051532)3.20244803
53protein export from nucleus (GO:0006611)3.19808622
54histone H4-K5 acetylation (GO:0043981)3.18310037
55histone H4-K8 acetylation (GO:0043982)3.18310037
56formation of translation preinitiation complex (GO:0001731)3.18002400
57histone H2A monoubiquitination (GO:0035518)3.14178455
58NLS-bearing protein import into nucleus (GO:0006607)3.13864178
59dosage compensation (GO:0007549)3.13751214
60locomotory exploration behavior (GO:0035641)3.13286160
61ribosome biogenesis (GO:0042254)3.12837038
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07511249
63regulation of translational elongation (GO:0006448)3.06710916
64pore complex assembly (GO:0046931)3.04109367
65mitotic G1/S transition checkpoint (GO:0044819)3.02889507
66mitotic sister chromatid segregation (GO:0000070)3.00680604
67determination of adult lifespan (GO:0008340)3.00605744
68regulation of histone H3-K27 methylation (GO:0061085)2.96828826
69regulation of RNA export from nucleus (GO:0046831)2.94792046
70positive regulation of synapse maturation (GO:0090129)2.92894199
71regulation of hippo signaling (GO:0035330)2.92808028
72regulation of histone H3-K9 methylation (GO:0051570)2.92739103
73negative regulation of cell size (GO:0045792)2.91597154
74protein retention in ER lumen (GO:0006621)2.91559210
75protein localization to chromosome, centromeric region (GO:0071459)2.87875622
76regulation of chromatin binding (GO:0035561)2.87172401
77mitotic sister chromatid cohesion (GO:0007064)2.87121645
78purine nucleobase biosynthetic process (GO:0009113)2.85030319
79nodal signaling pathway (GO:0038092)2.84564062
80DNA replication initiation (GO:0006270)2.83884734
81NADPH regeneration (GO:0006740)2.83766009
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.83700330
83regulation of nucleobase-containing compound transport (GO:0032239)2.83235657
84ribosome assembly (GO:0042255)2.80638440
85layer formation in cerebral cortex (GO:0021819)2.80552407
86maternal placenta development (GO:0001893)2.79486449
87chromatin silencing (GO:0006342)2.78312961
88sister chromatid segregation (GO:0000819)2.78225244
89positive regulation of nuclease activity (GO:0032075)2.77895588
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.76575341
91negative regulation of mRNA processing (GO:0050686)2.76007332
92synaptic vesicle docking involved in exocytosis (GO:0016081)2.75801455
93chromatin assembly (GO:0031497)2.75419947
94snRNA processing (GO:0016180)2.74412012
95regulation of early endosome to late endosome transport (GO:2000641)2.74295026
96rRNA transcription (GO:0009303)2.73590653
97tRNA methylation (GO:0030488)2.73549817
98establishment of apical/basal cell polarity (GO:0035089)2.72925824
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72630440
100desmosome organization (GO:0002934)2.71881124
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71605043
102negative regulation of mRNA metabolic process (GO:1903312)2.70755206
103embryonic process involved in female pregnancy (GO:0060136)2.70654640
104pinocytosis (GO:0006907)2.69833275
105negative regulation of RNA splicing (GO:0033119)2.69716705
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69600865
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68733162
108sodium ion export (GO:0071436)2.68672064
109DNA strand elongation (GO:0022616)2.68248668
110positive regulation of gene expression, epigenetic (GO:0045815)2.67942561
111G1 DNA damage checkpoint (GO:0044783)2.67850022
112glucose catabolic process (GO:0006007)2.67207237
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.66797822
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66094874
115histone H4 acetylation (GO:0043967)2.65560641
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65510458
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.65510458
118mitochondrial fusion (GO:0008053)2.64605148
119histone H4-K16 acetylation (GO:0043984)2.63978277
120chromosome condensation (GO:0030261)2.63858591
121mannose metabolic process (GO:0006013)2.63148715
122ribonucleoprotein complex biogenesis (GO:0022613)2.62069430
123mRNA transport (GO:0051028)2.61960084
124endoplasmic reticulum unfolded protein response (GO:0030968)2.61568916
125negative regulation of histone modification (GO:0031057)2.61542181
126adherens junction assembly (GO:0034333)2.60179450
127folic acid metabolic process (GO:0046655)2.59778150
128skin morphogenesis (GO:0043589)2.59533953
129negative regulation of erythrocyte differentiation (GO:0045647)2.58861414
130anterior/posterior axis specification, embryo (GO:0008595)2.57114968
131nuclear envelope reassembly (GO:0031468)2.56949070
132mitotic nuclear envelope reassembly (GO:0007084)2.56949070
133trophectodermal cell differentiation (GO:0001829)2.56863081
134negative regulation of telomerase activity (GO:0051974)2.56633340
135regulation of glucose import in response to insulin stimulus (GO:2001273)2.55816637
136nucleosome disassembly (GO:0006337)2.55468777
137protein-DNA complex disassembly (GO:0032986)2.55468777
138DNA strand elongation involved in DNA replication (GO:0006271)2.54105433
139basement membrane organization (GO:0071711)2.54034512
140nucleobase-containing small molecule interconversion (GO:0015949)2.53602376
141regulation of nuclease activity (GO:0032069)2.53398730
142epithelial cell-cell adhesion (GO:0090136)2.53078455
143regulation of spindle organization (GO:0090224)2.52709812
1443-UTR-mediated mRNA stabilization (GO:0070935)2.52647142
145proline metabolic process (GO:0006560)2.52452364
146ER-nucleus signaling pathway (GO:0006984)2.52399795
147gene silencing (GO:0016458)2.52001211
148positive regulation of RNA splicing (GO:0033120)2.51484300
149mRNA stabilization (GO:0048255)2.51423427
150RNA stabilization (GO:0043489)2.51423427
151corticosteroid receptor signaling pathway (GO:0031958)2.51172048
152protein complex localization (GO:0031503)2.50240182
153snRNA metabolic process (GO:0016073)2.49815425
154positive regulation of chromosome segregation (GO:0051984)2.49695114
155negative regulation of gene expression, epigenetic (GO:0045814)2.49180184
156DNA conformation change (GO:0071103)2.48392462
157positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.46514326
158ncRNA 3-end processing (GO:0043628)2.45983640
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45685004
160stress fiber assembly (GO:0043149)2.43665401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79923756
2MYC_22102868_ChIP-Seq_BL_Human3.48771232
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.42986854
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.40890245
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.12566791
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05390671
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.85291445
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68361251
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55965066
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48232007
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28191389
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26532089
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25149530
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21878923
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05310971
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99131979
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95871773
18KDM2B_26808549_Chip-Seq_DND41_Human1.93256802
19CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.90121800
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89525913
21ZNF263_19887448_ChIP-Seq_K562_Human1.85915452
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.83379217
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83180767
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80514994
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78486945
26CIITA_25753668_ChIP-Seq_RAJI_Human1.74993537
27VDR_21846776_ChIP-Seq_THP-1_Human1.74107321
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70725902
29XRN2_22483619_ChIP-Seq_HELA_Human1.69979420
30TCF7_22412390_ChIP-Seq_EML_Mouse1.69570044
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68634403
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66965366
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66305192
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65798456
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64828166
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59991706
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59910335
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58967947
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58089437
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55636298
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54423566
42LXR_22292898_ChIP-Seq_THP-1_Human1.52835450
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51407559
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48092486
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.46870282
46* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44408599
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44362439
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.44126190
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43065924
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42723331
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.41245038
52DCP1A_22483619_ChIP-Seq_HELA_Human1.40190672
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39455389
54CLOCK_20551151_ChIP-Seq_293T_Human1.39079523
55* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37179740
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36986086
57* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36430816
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36320024
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36148700
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36148700
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36148700
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35614841
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35454387
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35390034
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35376663
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.34332585
67KDM5A_27292631_Chip-Seq_BREAST_Human1.34244499
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33667122
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32904456
70AR_21909140_ChIP-Seq_LNCAP_Human1.28853392
71KDM2B_26808549_Chip-Seq_K562_Human1.28683474
72P68_20966046_ChIP-Seq_HELA_Human1.28540175
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27290116
74RACK7_27058665_Chip-Seq_MCF-7_Human1.26063846
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24790104
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24042043
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.23902245
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.23830365
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.23638487
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22179558
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21201057
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20850075
83NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20609393
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19712527
85ATF3_27146783_Chip-Seq_COLON_Human1.18657609
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18570413
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17558992
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16552986
89* ETS1_20019798_ChIP-Seq_JURKAT_Human1.16082534
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15497779
91CREB1_26743006_Chip-Seq_LNCaP_Human1.14922157
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13245044
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12722596
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12404951
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12337754
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12191407
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10996545
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10695489
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10457026
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08931007
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08785332
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.08783135
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08658905
104* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08512356
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07960820
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06911236
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06715715
108* ELF1_20517297_ChIP-Seq_JURKAT_Human1.06126755
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05426193
110OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05212262
111NCOR1_26117541_ChIP-Seq_K562_Human1.04861888
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04474551
113MAF_26560356_Chip-Seq_TH2_Human1.04251417
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03393078
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03143490
116UTX_26944678_Chip-Seq_JUKART_Human1.02675037
117GABP_19822575_ChIP-Seq_HepG2_Human1.02120538
118TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02062519
119CHD1_26751641_Chip-Seq_LNCaP_Human1.01945119
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01760771
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01518324
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00882289
123SA1_27219007_Chip-Seq_ERYTHROID_Human1.00437358
124* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00422318
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00176636
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99023832
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.98693412
128* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98056220
129MAF_26560356_Chip-Seq_TH1_Human0.97786185
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97641261
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97487434
132* PHF8_20622854_ChIP-Seq_HELA_Human0.97334124
133SMC4_20622854_ChIP-Seq_HELA_Human0.97231890
134TFEB_21752829_ChIP-Seq_HELA_Human0.96940518
135TTF2_22483619_ChIP-Seq_HELA_Human0.96498356
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95649209
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95083348
138TP53_22127205_ChIP-Seq_IMR90_Human0.93807961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.10755430
2MP0003111_abnormal_nucleus_morphology3.42084546
3MP0010352_gastrointestinal_tract_polyps3.19104736
4MP0005451_abnormal_body_composition3.18756004
5MP0003705_abnormal_hypodermis_morpholog2.98918726
6MP0004957_abnormal_blastocyst_morpholog2.79847505
7MP0008438_abnormal_cutaneous_collagen2.75492360
8MP0005076_abnormal_cell_differentiation2.74420591
9MP0010094_abnormal_chromosome_stability2.69789498
10MP0003123_paternal_imprinting2.66517122
11MP0003693_abnormal_embryo_hatching2.59501608
12MP0001730_embryonic_growth_arrest2.58105336
13MP0003077_abnormal_cell_cycle2.48471766
14MP0008961_abnormal_basal_metabolism2.34454797
15MP0002653_abnormal_ependyma_morphology2.27723216
16MP0008057_abnormal_DNA_replication2.24623878
17MP0002796_impaired_skin_barrier2.19537529
18MP0003283_abnormal_digestive_organ2.19510851
19MP0010307_abnormal_tumor_latency2.12075551
20MP0000350_abnormal_cell_proliferation2.09221441
21MP0002084_abnormal_developmental_patter1.97032314
22MP0001849_ear_inflammation1.96252788
23MP0003453_abnormal_keratinocyte_physiol1.95143621
24MP0004858_abnormal_nervous_system1.93788450
25MP0008260_abnormal_autophagy1.88770605
26MP0010234_abnormal_vibrissa_follicle1.88643111
27MP0002060_abnormal_skin_morphology1.87211164
28MP0004233_abnormal_muscle_weight1.87086139
29MP0001672_abnormal_embryogenesis/_devel1.83857047
30MP0005380_embryogenesis_phenotype1.83857047
31MP0005501_abnormal_skin_physiology1.77314934
32MP0001697_abnormal_embryo_size1.73235413
33MP0002086_abnormal_extraembryonic_tissu1.73199649
34MP0004197_abnormal_fetal_growth/weight/1.72509207
35MP0002085_abnormal_embryonic_tissue1.70881862
36MP0003984_embryonic_growth_retardation1.70234588
37MP0002088_abnormal_embryonic_growth/wei1.67069092
38MP0003119_abnormal_digestive_system1.66866063
39MP0002080_prenatal_lethality1.66795241
40MP0009840_abnormal_foam_cell1.66285303
41MP0003635_abnormal_synaptic_transmissio1.63126691
42MP0004272_abnormal_basement_membrane1.54455991
43MP0002396_abnormal_hematopoietic_system1.54319225
44MP0000579_abnormal_nail_morphology1.52774570
45MP0003890_abnormal_embryonic-extraembry1.50491477
46MP0000678_abnormal_parathyroid_gland1.47467446
47MP0000537_abnormal_urethra_morphology1.47102803
48MP0003121_genomic_imprinting1.42676465
49MP0005058_abnormal_lysosome_morphology1.41524657
50MP0008877_abnormal_DNA_methylation1.41127611
51MP0001661_extended_life_span1.37871620
52MP0005257_abnormal_intraocular_pressure1.35194953
53MP0003566_abnormal_cell_adhesion1.34562155
54MP0001216_abnormal_epidermal_layer1.34260022
55MP0003941_abnormal_skin_development1.33020671
56MP0000858_altered_metastatic_potential1.29878616
57MP0010030_abnormal_orbit_morphology1.29795443
58MP0008007_abnormal_cellular_replicative1.28315407
59MP0002063_abnormal_learning/memory/cond1.26735554
60MP0009672_abnormal_birth_weight1.26693772
61MP0008770_decreased_survivor_rate1.23276998
62MP0004133_heterotaxia1.22481281
63MP0004811_abnormal_neuron_physiology1.21463354
64MP0000751_myopathy1.19628080
65MP0002089_abnormal_postnatal_growth/wei1.17465008
66MP0004185_abnormal_adipocyte_glucose1.16665800
67MP0003172_abnormal_lysosome_physiology1.16514990
68MP0000490_abnormal_crypts_of1.16375862
69MP0000003_abnormal_adipose_tissue1.14740813
70MP0004947_skin_inflammation1.13836338
71MP0002822_catalepsy1.13607761
72MP0004270_analgesia1.12268668
73MP0008058_abnormal_DNA_repair1.12032896
74MP0009278_abnormal_bone_marrow1.11715885
75MP0003763_abnormal_thymus_physiology1.11556473
76MP0005394_taste/olfaction_phenotype1.11051102
77MP0005499_abnormal_olfactory_system1.11051102
78MP0002877_abnormal_melanocyte_morpholog1.10667637
79MP0001915_intracranial_hemorrhage1.10604287
80MP0001348_abnormal_lacrimal_gland1.09262635
81MP0004885_abnormal_endolymph1.08749337
82MP0009703_decreased_birth_body1.08010553
83MP0005409_darkened_coat_color1.08002028
84MP0003861_abnormal_nervous_system1.06067007
85MP0000467_abnormal_esophagus_morphology1.05715048
86MP0002909_abnormal_adrenal_gland1.05013805
87MP0005397_hematopoietic_system_phenotyp1.04987122
88MP0001545_abnormal_hematopoietic_system1.04987122
89MP0004808_abnormal_hematopoietic_stem1.03785234
90MP0002269_muscular_atrophy1.01481995
91MP0003303_peritoneal_inflammation1.01369867
92MP0009333_abnormal_splenocyte_physiolog1.00990663
93MP0008932_abnormal_embryonic_tissue0.99073967
94MP0009931_abnormal_skin_appearance0.98546183
95MP0000759_abnormal_skeletal_muscle0.97751252
96MP0000428_abnormal_craniofacial_morphol0.96502029
97MP0000313_abnormal_cell_death0.96335193
98MP0000733_abnormal_muscle_development0.95760174
99MP0005623_abnormal_meninges_morphology0.94937459
100MP0003122_maternal_imprinting0.93044794
101MP0001873_stomach_inflammation0.92333596
102MP0005375_adipose_tissue_phenotype0.91926992
103MP0009780_abnormal_chondrocyte_physiolo0.91816418
104MP0009053_abnormal_anal_canal0.91161400
105MP0003191_abnormal_cellular_cholesterol0.91035375
106MP0005621_abnormal_cell_physiology0.90571091
107MP0000762_abnormal_tongue_morphology0.90481648
108MP0001293_anophthalmia0.88057753
109MP0010771_integument_phenotype0.87325957
110MP0002019_abnormal_tumor_incidence0.84765651
111MP0005023_abnormal_wound_healing0.84613101
112MP0005384_cellular_phenotype0.84597715
113MP0002254_reproductive_system_inflammat0.84238026
114MP0003329_amyloid_beta_deposits0.83993138
115MP0004087_abnormal_muscle_fiber0.83232819
116MP0005275_abnormal_skin_tensile0.82263484
117MP0003300_gastrointestinal_ulcer0.82253012
118MP0010630_abnormal_cardiac_muscle0.82240992
119MP0003950_abnormal_plasma_membrane0.81391663
120MP0000703_abnormal_thymus_morphology0.81042773
121MP0002152_abnormal_brain_morphology0.81018399
122MP0002925_abnormal_cardiovascular_devel0.80905632
123MP0001243_abnormal_dermal_layer0.78984718
124MP0005666_abnormal_adipose_tissue0.78593208
125MP0004264_abnormal_extraembryonic_tissu0.78409380
126MP0000955_abnormal_spinal_cord0.77661892
127MP0000750_abnormal_muscle_regeneration0.77553587
128MP0000534_abnormal_ureter_morphology0.77196301
129MP0005670_abnormal_white_adipose0.77023376
130MP0003115_abnormal_respiratory_system0.76631410
131MP0000377_abnormal_hair_follicle0.75898693
132MP0000358_abnormal_cell_content/0.75299308
133MP0002098_abnormal_vibrissa_morphology0.74842813
134MP0003786_premature_aging0.74623350
135MP0002064_seizures0.74447458
136MP0005187_abnormal_penis_morphology0.73979222
137MP0004782_abnormal_surfactant_physiolog0.73786327
138MP0003091_abnormal_cell_migration0.73195342
139MP0003787_abnormal_imprinting0.72981895
140MP0000627_abnormal_mammary_gland0.72799892
141MP0008872_abnormal_physiological_respon0.72680182
142MP0000747_muscle_weakness0.69546022

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.58316956
2Abnormality of the lower motor neuron (HP:0002366)4.40543974
3Premature rupture of membranes (HP:0001788)3.96641670
4Astrocytoma (HP:0009592)3.78121960
5Abnormality of the astrocytes (HP:0100707)3.78121960
6Hyperacusis (HP:0010780)3.55433298
7Annular pancreas (HP:0001734)3.18394359
8Distal lower limb amyotrophy (HP:0008944)3.12836758
9Protrusio acetabuli (HP:0003179)3.06824401
10Trismus (HP:0000211)3.06265606
11Pointed chin (HP:0000307)2.94435283
12Ulnar bowing (HP:0003031)2.84568797
13Glioma (HP:0009733)2.83722113
14Selective tooth agenesis (HP:0001592)2.82074958
15Broad face (HP:0000283)2.80217926
16Long palpebral fissure (HP:0000637)2.78690728
17Progressive muscle weakness (HP:0003323)2.75381006
18Short nail (HP:0001799)2.73508819
19Distal upper limb amyotrophy (HP:0007149)2.73496458
20Upper limb amyotrophy (HP:0009129)2.73496458
21Hand muscle atrophy (HP:0009130)2.73130929
22Insomnia (HP:0100785)2.71562290
23Abnormality of the labia minora (HP:0012880)2.71332752
24Increased connective tissue (HP:0009025)2.68250969
25Medulloblastoma (HP:0002885)2.64945347
26Neoplasm of the oral cavity (HP:0100649)2.58380814
27Basal cell carcinoma (HP:0002671)2.54624452
28Fragile skin (HP:0001030)2.54377944
29Renal duplication (HP:0000075)2.54133654
30Myokymia (HP:0002411)2.53541024
31Vertebral compression fractures (HP:0002953)2.46581124
32Resting tremor (HP:0002322)2.44518667
33Sparse lateral eyebrow (HP:0005338)2.44207559
34Dysmetric saccades (HP:0000641)2.43319326
35Lower limb amyotrophy (HP:0007210)2.41023890
36Neoplasm of striated muscle (HP:0009728)2.40650430
37Atrophic scars (HP:0001075)2.39621822
38Elbow flexion contracture (HP:0002987)2.39480276
39Amyotrophic lateral sclerosis (HP:0007354)2.36060888
40Ankyloglossia (HP:0010296)2.34643418
41Distal lower limb muscle weakness (HP:0009053)2.32066771
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.31363055
43Elfin facies (HP:0004428)2.30954836
44Increased nuchal translucency (HP:0010880)2.30491986
45Flat acetabular roof (HP:0003180)2.28332326
46Natal tooth (HP:0000695)2.25999693
47Colon cancer (HP:0003003)2.25497632
48Spinal rigidity (HP:0003306)2.24528194
49Visual hallucinations (HP:0002367)2.24405275
50Disproportionate tall stature (HP:0001519)2.23454020
51Osteolytic defects of the hand bones (HP:0009699)2.20155131
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.20155131
53Rhabdomyosarcoma (HP:0002859)2.18681620
54Cerebral aneurysm (HP:0004944)2.18396556
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.18184562
56Adenoma sebaceum (HP:0009720)2.16743228
57Angiofibromas (HP:0010615)2.16743228
58Neoplasm of the heart (HP:0100544)2.16276706
59Achilles tendon contracture (HP:0001771)2.13964930
60Impaired smooth pursuit (HP:0007772)2.13365167
61Abnormal neuron morphology (HP:0012757)2.12777213
62Abnormality of the motor neurons (HP:0002450)2.12777213
63Overriding aorta (HP:0002623)2.12536758
64Advanced eruption of teeth (HP:0006288)2.11909747
65Asymmetry of the thorax (HP:0001555)2.11592037
66Premature skin wrinkling (HP:0100678)2.11250529
67Spinal muscular atrophy (HP:0007269)2.11019216
68Ragged-red muscle fibers (HP:0003200)2.10424704
69Abnormality of the thoracic spine (HP:0100711)2.09628748
70Progressive external ophthalmoplegia (HP:0000590)2.08560829
71Bowel diverticulosis (HP:0005222)2.07956444
72Renovascular hypertension (HP:0100817)2.06436596
73Missing ribs (HP:0000921)2.04939402
74Urinary urgency (HP:0000012)2.02244778
75Thin bony cortex (HP:0002753)1.99842172
76Mildly elevated creatine phosphokinase (HP:0008180)1.97994687
77Abnormality of the distal phalanges of the toes (HP:0010182)1.97554987
78Fibroma (HP:0010614)1.97012690
79Generalized amyotrophy (HP:0003700)1.96750409
80Impaired vibration sensation in the lower limbs (HP:0002166)1.96505965
81Genu recurvatum (HP:0002816)1.95419463
82Blue sclerae (HP:0000592)1.94850242
83Pelvic girdle muscle weakness (HP:0003749)1.94823729
84Reticulocytosis (HP:0001923)1.93401486
85Pseudobulbar signs (HP:0002200)1.93237645
86Rough bone trabeculation (HP:0100670)1.92349741
87Back pain (HP:0003418)1.91009430
88Abnormality of the anterior horn cell (HP:0006802)1.90981884
89Degeneration of anterior horn cells (HP:0002398)1.90981884
90Urethral obstruction (HP:0000796)1.90487919
91Ankle contracture (HP:0006466)1.90385747
92Milia (HP:0001056)1.89447598
93Abnormality of oral frenula (HP:0000190)1.88883642
94Hemiplegia (HP:0002301)1.88845899
95Short 4th metacarpal (HP:0010044)1.88600628
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88600628
97Ridged nail (HP:0001807)1.88534261
98Heterotopia (HP:0002282)1.88495105
99Breast hypoplasia (HP:0003187)1.88387247
100Syringomyelia (HP:0003396)1.88162085
101Spinal cord lesions (HP:0100561)1.88162085
102Abnormality of ocular smooth pursuit (HP:0000617)1.88103297
103Broad palm (HP:0001169)1.87191983
104Microvesicular hepatic steatosis (HP:0001414)1.86911891
105Macroorchidism (HP:0000053)1.86302295
106Reduced subcutaneous adipose tissue (HP:0003758)1.85774522
107Abnormality of the Achilles tendon (HP:0005109)1.85764128
108Fibrous tissue neoplasm (HP:0012316)1.85463362
109Skin tags (HP:0010609)1.85389771
110Abnormal number of incisors (HP:0011064)1.85269471
111Shoulder girdle muscle weakness (HP:0003547)1.84778090
112Mitral regurgitation (HP:0001653)1.84676971
113Long eyelashes (HP:0000527)1.84627129
114Focal seizures (HP:0007359)1.82442240
115Entropion (HP:0000621)1.82378792
116Megalocornea (HP:0000485)1.81557748
117Bladder diverticulum (HP:0000015)1.81489794
118Patellar dislocation (HP:0002999)1.79591769
119Cerebral hypomyelination (HP:0006808)1.78536373
120J-shaped sella turcica (HP:0002680)1.77297718
121Attention deficit hyperactivity disorder (HP:0007018)1.76562191
122Agnosia (HP:0010524)1.76504356
123Proximal placement of thumb (HP:0009623)1.76008232
124Myopathic facies (HP:0002058)1.75979784
125Deep palmar crease (HP:0006191)1.75571864
126Intellectual disability, profound (HP:0002187)1.75443378
127Prominent nose (HP:0000448)1.75089984
128Wormian bones (HP:0002645)1.74807718
129Abnormal social behavior (HP:0012433)1.74691205
130Impaired social interactions (HP:0000735)1.74691205
131Malignant gastrointestinal tract tumors (HP:0006749)1.74575497
132Gastrointestinal carcinoma (HP:0002672)1.74575497
133Obsessive-compulsive behavior (HP:0000722)1.73814151
134Deviation of the thumb (HP:0009603)1.73544074
135Thick nail (HP:0001805)1.73494555
136Stridor (HP:0010307)1.72398477
137Cervical subluxation (HP:0003308)1.71619677
138Trigonocephaly (HP:0000243)1.70589057
139Cafe-au-lait spot (HP:0000957)1.70386737
140Abnormality of the calcaneus (HP:0008364)1.70280232
141Shallow orbits (HP:0000586)1.69466164
142Preauricular skin tag (HP:0000384)1.68508552
143Nail dystrophy (HP:0008404)1.68507986
144Squamous cell carcinoma (HP:0002860)1.68371398
145Malignant neoplasm of the central nervous system (HP:0100836)1.66680928
146Abnormality of the salivary glands (HP:0010286)1.65311312
147Abnormal gallbladder physiology (HP:0012438)1.64237718
148Cholecystitis (HP:0001082)1.64237718
149Thoracic kyphosis (HP:0002942)1.64189513
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.63944466
151Biconcave vertebral bodies (HP:0004586)1.63580302
152Broad thumb (HP:0011304)1.63381286
153Spastic diplegia (HP:0001264)1.62934122
154Poor eye contact (HP:0000817)1.62933002
155Short 1st metacarpal (HP:0010034)1.62702224
156Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62702224
157Abnormality of the diencephalon (HP:0010662)1.62443983
158Difficulty climbing stairs (HP:0003551)1.62308046
159Dislocated radial head (HP:0003083)1.61922459
160Abnormality of skeletal muscle fiber size (HP:0012084)1.61817994
161Short phalanx of the thumb (HP:0009660)1.61003745
162Multiple enchondromatosis (HP:0005701)1.60326046
163Increased variability in muscle fiber diameter (HP:0003557)1.60273851
164Enlarged penis (HP:0000040)1.59523068
165Abnormal ossification of hand bones (HP:0005921)1.59179440
166Limb-girdle muscle atrophy (HP:0003797)1.58852012
167Abnormality of nail color (HP:0100643)1.57844361
168Fragile nails (HP:0001808)1.57705274
169Short humerus (HP:0005792)1.57211512
170Sacral dimple (HP:0000960)1.56818423
171Hypopigmentation of the fundus (HP:0007894)1.56703759
172Abnormality of the musculature of the pelvis (HP:0001469)1.56681842
173Spinal cord compression (HP:0002176)1.56455034
174Abnormality of the umbilical cord (HP:0010881)1.55984838
175Abnormality of dentin (HP:0010299)1.55657268
176Mitral valve prolapse (HP:0001634)1.54961907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.30125467
2CDK123.64422512
3EEF2K3.51619544
4TRIB33.19197128
5IRAK33.14579171
6PRPF4B2.86992156
7NEK12.86208140
8MAP3K92.55017926
9PKN22.44557982
10ALK2.37978605
11NME22.33302748
12MST1R2.29339355
13PRKD32.24316189
14CDC72.17882564
15SCYL22.14230121
16MAP3K102.07499539
17TAOK12.07448201
18LATS21.91585421
19KSR21.88815044
20TSSK61.87183577
21TYRO31.76003073
22ICK1.71484904
23PAK61.66371382
24FGFR41.57203442
25NEK21.46843397
26PTK21.42726196
27RIPK11.39161055
28MET1.38184152
29PDGFRA1.37803164
30CAMKK11.35277111
31NTRK31.33242811
32RPS6KB21.32406187
33KSR11.27639117
34MTOR1.26245685
35MINK11.21696032
36WEE11.20669587
37DAPK11.17251000
38SIK21.16575653
39MAP3K131.14911302
40EPHA41.09458216
41BRD41.09181897
42NTRK21.08753977
43MAP3K81.07067598
44TESK11.07056279
45SRPK11.05847083
46CDK41.05396447
47TTK1.02831574
48EPHA21.02762883
49BMX1.02378386
50BUB11.01297245
51ARAF1.00298048
52CHEK10.99610709
53CDK70.99060471
54LMTK20.98016409
55TESK20.96010846
56PIM20.94704459
57PASK0.94369257
58STK380.94153902
59MAP3K110.93429509
60PAK40.91042064
61DAPK20.90288949
62MAP3K40.89030802
63MAPK110.88921538
64EIF2AK10.86729254
65CDK20.86446728
66ATR0.86436423
67RAF10.85836211
68BRSK10.81178059
69PLK10.75449414
70GRK60.74080861
71ERBB40.73050130
72BRAF0.72550116
73CSNK1E0.71669091
74FGFR10.71349143
75STK100.71247989
76EPHB10.70547590
77PNCK0.68000752
78NTRK10.67679097
79ERN10.67343359
80PAK20.67186795
81CDC42BPA0.65316275
82PRKD20.64696433
83TAOK20.64675008
84MAP4K10.63855407
85MAP3K140.63567455
86MARK10.63475021
87LRRK20.63248233
88CAMK1D0.62762333
89UHMK10.62372968
90MAP3K30.61757788
91AKT20.61622606
92MARK20.61520077
93PLK30.59430623
94RET0.58655097
95CDK150.57989127
96PTK60.57561418
97MAP3K70.57132236
98CDK180.56194996
99CAMK40.54405500
100CDK90.54339327
101CDK80.54044768
102DDR20.54029279
103CDK11A0.53884491
104CLK10.53675327
105MAPK100.53293984
106RPS6KA20.53261030
107CDK60.53175738
108PRKCH0.51963000
109STK110.50660960
110TTN0.50388757
111MOS0.50170927
112RPS6KA10.49956252
113MAP3K10.49780633
114CSNK1D0.49551637
115CDK10.49015377
116CHEK20.48749050
117MAPKAPK30.48123008
118AURKB0.47394488
119FLT30.47169408
120CDK140.46506314
121LATS10.46081524
122CAMK1G0.45863037
123ATM0.45844856
124PDPK10.45630007
125AURKA0.45116221
126GSK3B0.44034113
127IRAK20.43781676
128CDK50.43480136
129PAK10.43185848
130PBK0.42657710
131MAP2K40.42613091
132MELK0.41673424
133MAP2K30.41235103
134MAP3K60.41077091
135TAF10.40082707
136MAPK140.39769302
137SIK10.39416227
138ILK0.37232844
139TRPM70.34988944
140RPS6KC10.34474549
141RPS6KL10.34474549
142JAK30.32630260
143PDGFRB0.32037170
144STK40.30824510
145PRKCI0.29425651

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.40514781
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29078484
3DNA replication_Homo sapiens_hsa030302.21527277
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09329714
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93561801
6One carbon pool by folate_Homo sapiens_hsa006701.92824061
7Mismatch repair_Homo sapiens_hsa034301.89014123
8mTOR signaling pathway_Homo sapiens_hsa041501.85232001
9Spliceosome_Homo sapiens_hsa030401.84617900
10Nitrogen metabolism_Homo sapiens_hsa009101.84010676
11mRNA surveillance pathway_Homo sapiens_hsa030151.81209140
12Pentose phosphate pathway_Homo sapiens_hsa000301.80607590
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75689616
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64461463
15Oocyte meiosis_Homo sapiens_hsa041141.54393589
16Pancreatic cancer_Homo sapiens_hsa052121.53724475
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45261378
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44975812
19Fructose and mannose metabolism_Homo sapiens_hsa000511.44634076
20Base excision repair_Homo sapiens_hsa034101.38242699
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.38154744
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36527320
23Cell cycle_Homo sapiens_hsa041101.36404320
24Long-term potentiation_Homo sapiens_hsa047201.36127930
25Synaptic vesicle cycle_Homo sapiens_hsa047211.35799784
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35786187
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.35688595
28Glioma_Homo sapiens_hsa052141.35652829
29Other glycan degradation_Homo sapiens_hsa005111.35280211
30Biosynthesis of amino acids_Homo sapiens_hsa012301.34248537
31Vitamin B6 metabolism_Homo sapiens_hsa007501.33490105
32Chronic myeloid leukemia_Homo sapiens_hsa052201.30651115
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.28364497
34Non-small cell lung cancer_Homo sapiens_hsa052231.27203763
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23330570
36Sulfur relay system_Homo sapiens_hsa041221.23036543
37Focal adhesion_Homo sapiens_hsa045101.16919934
38Colorectal cancer_Homo sapiens_hsa052101.16708966
39Carbon metabolism_Homo sapiens_hsa012001.15891613
40Endometrial cancer_Homo sapiens_hsa052131.13947186
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13303724
42VEGF signaling pathway_Homo sapiens_hsa043701.12096284
43N-Glycan biosynthesis_Homo sapiens_hsa005101.10263967
44Thyroid cancer_Homo sapiens_hsa052161.10103492
45Prostate cancer_Homo sapiens_hsa052151.08118212
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07496179
47Selenocompound metabolism_Homo sapiens_hsa004501.05647577
48Estrogen signaling pathway_Homo sapiens_hsa049151.05554723
49Apoptosis_Homo sapiens_hsa042101.03656036
50Hippo signaling pathway_Homo sapiens_hsa043901.03410169
51Prion diseases_Homo sapiens_hsa050201.02747940
52Hepatitis B_Homo sapiens_hsa051611.01209260
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01164016
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96283476
55Pyrimidine metabolism_Homo sapiens_hsa002400.96055806
56Acute myeloid leukemia_Homo sapiens_hsa052210.95963994
57ErbB signaling pathway_Homo sapiens_hsa040120.95600341
58ECM-receptor interaction_Homo sapiens_hsa045120.95509307
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95447796
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94805892
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94240171
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93421849
63Galactose metabolism_Homo sapiens_hsa000520.92672963
64Notch signaling pathway_Homo sapiens_hsa043300.92204060
65Olfactory transduction_Homo sapiens_hsa047400.92047680
66Shigellosis_Homo sapiens_hsa051310.91972634
67MicroRNAs in cancer_Homo sapiens_hsa052060.91635578
68Bladder cancer_Homo sapiens_hsa052190.90376821
69Gap junction_Homo sapiens_hsa045400.87964630
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84894332
71HTLV-I infection_Homo sapiens_hsa051660.84732373
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84120250
73Amphetamine addiction_Homo sapiens_hsa050310.84012422
74B cell receptor signaling pathway_Homo sapiens_hsa046620.83323281
75Insulin signaling pathway_Homo sapiens_hsa049100.83009485
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82780836
77HIF-1 signaling pathway_Homo sapiens_hsa040660.81637272
78Dopaminergic synapse_Homo sapiens_hsa047280.80378570
79Type II diabetes mellitus_Homo sapiens_hsa049300.79571128
80GnRH signaling pathway_Homo sapiens_hsa049120.77439912
81Viral carcinogenesis_Homo sapiens_hsa052030.77232498
82Lysine degradation_Homo sapiens_hsa003100.77095706
83Non-homologous end-joining_Homo sapiens_hsa034500.76294977
84Hepatitis C_Homo sapiens_hsa051600.76090814
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75196132
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74577936
87Nucleotide excision repair_Homo sapiens_hsa034200.73692918
88Proteoglycans in cancer_Homo sapiens_hsa052050.73140165
89Dorso-ventral axis formation_Homo sapiens_hsa043200.72508421
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71437752
91Renal cell carcinoma_Homo sapiens_hsa052110.70862367
92Oxytocin signaling pathway_Homo sapiens_hsa049210.70596014
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69733856
94Inositol phosphate metabolism_Homo sapiens_hsa005620.69393028
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69331812
96Circadian entrainment_Homo sapiens_hsa047130.68800522
97AMPK signaling pathway_Homo sapiens_hsa041520.68689632
98Influenza A_Homo sapiens_hsa051640.68638900
99Glucagon signaling pathway_Homo sapiens_hsa049220.68404173
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66837302
101Gastric acid secretion_Homo sapiens_hsa049710.64859479
102Prolactin signaling pathway_Homo sapiens_hsa049170.64704412
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63010645
104p53 signaling pathway_Homo sapiens_hsa041150.62992830
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.62914769
106Basal cell carcinoma_Homo sapiens_hsa052170.62666656
107Amoebiasis_Homo sapiens_hsa051460.62007210
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61972666
109MAPK signaling pathway_Homo sapiens_hsa040100.61013780
110Cocaine addiction_Homo sapiens_hsa050300.60547446
111Epstein-Barr virus infection_Homo sapiens_hsa051690.60219243
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59628514
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59380888
114Measles_Homo sapiens_hsa051620.58815858
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.58450203
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58275610
117TNF signaling pathway_Homo sapiens_hsa046680.58127166
118Melanogenesis_Homo sapiens_hsa049160.57278242
119Toxoplasmosis_Homo sapiens_hsa051450.57096551
120Endocytosis_Homo sapiens_hsa041440.57003109
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56519748
122Cholinergic synapse_Homo sapiens_hsa047250.56393735
123Insulin secretion_Homo sapiens_hsa049110.56350502
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56214876
125GABAergic synapse_Homo sapiens_hsa047270.56120921
126Adherens junction_Homo sapiens_hsa045200.55481697
127Herpes simplex infection_Homo sapiens_hsa051680.55111808
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.54987081
129Rap1 signaling pathway_Homo sapiens_hsa040150.54485634
130RNA degradation_Homo sapiens_hsa030180.54009980
131Small cell lung cancer_Homo sapiens_hsa052220.53464097
132Melanoma_Homo sapiens_hsa052180.53089404
133Insulin resistance_Homo sapiens_hsa049310.52771073
134Pathways in cancer_Homo sapiens_hsa052000.52451219
135T cell receptor signaling pathway_Homo sapiens_hsa046600.52325307
136Nicotine addiction_Homo sapiens_hsa050330.52302779
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52192446
138Glutamatergic synapse_Homo sapiens_hsa047240.51679008
139Vibrio cholerae infection_Homo sapiens_hsa051100.50772371
140Tight junction_Homo sapiens_hsa045300.50054889
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.48998229

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