NOL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.71004296
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.70071558
3viral transcription (GO:0019083)6.48496262
4translational termination (GO:0006415)6.29151432
5ribosomal small subunit biogenesis (GO:0042274)6.00880360
6ATP synthesis coupled proton transport (GO:0015986)5.79027345
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.79027345
8chaperone-mediated protein transport (GO:0072321)5.60463261
9DNA deamination (GO:0045006)5.45595919
10translational elongation (GO:0006414)5.44888598
11maturation of SSU-rRNA (GO:0030490)5.43590262
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39637151
13cotranslational protein targeting to membrane (GO:0006613)5.28639141
14protein targeting to ER (GO:0045047)5.27456811
15translational initiation (GO:0006413)5.09101924
16ribosomal large subunit biogenesis (GO:0042273)5.08676045
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.04873655
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.00898776
19protein localization to endoplasmic reticulum (GO:0070972)4.95665007
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.84674559
21viral life cycle (GO:0019058)4.83564336
22respiratory electron transport chain (GO:0022904)4.81967564
23cellular protein complex disassembly (GO:0043624)4.80689482
24electron transport chain (GO:0022900)4.68638443
25formation of translation preinitiation complex (GO:0001731)4.66654730
26DNA strand elongation involved in DNA replication (GO:0006271)4.44244799
27telomere maintenance via semi-conservative replication (GO:0032201)4.39686356
28protein complex disassembly (GO:0043241)4.29844574
29DNA strand elongation (GO:0022616)4.24743825
30ribonucleoprotein complex biogenesis (GO:0022613)4.22931082
31protein targeting to mitochondrion (GO:0006626)4.15588035
32translation (GO:0006412)4.04982323
33macromolecular complex disassembly (GO:0032984)4.04071811
34DNA replication initiation (GO:0006270)4.00553942
35telomere maintenance via recombination (GO:0000722)3.94647693
36oxidative phosphorylation (GO:0006119)3.89966779
37DNA replication checkpoint (GO:0000076)3.89653017
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.86209071
39mitochondrial respiratory chain complex assembly (GO:0033108)3.84068241
40protein complex biogenesis (GO:0070271)3.83586811
41establishment of protein localization to mitochondrion (GO:0072655)3.83014257
42protein neddylation (GO:0045116)3.78133419
43protein localization to mitochondrion (GO:0070585)3.77721082
44rRNA processing (GO:0006364)3.70797211
45regulation of cellular amino acid metabolic process (GO:0006521)3.68939973
46mRNA catabolic process (GO:0006402)3.67808820
47mitotic recombination (GO:0006312)3.67416974
48NADH dehydrogenase complex assembly (GO:0010257)3.62863555
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62863555
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.62863555
51DNA unwinding involved in DNA replication (GO:0006268)3.60392493
52rRNA metabolic process (GO:0016072)3.60118505
53RNA catabolic process (GO:0006401)3.59392420
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57640592
55proteasome assembly (GO:0043248)3.57434820
56regulation of mitochondrial translation (GO:0070129)3.56527025
57pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.55591557
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55052264
59establishment of viral latency (GO:0019043)3.53864291
60spliceosomal snRNP assembly (GO:0000387)3.52819390
61protein maturation by protein folding (GO:0022417)3.51192123
62CENP-A containing nucleosome assembly (GO:0034080)3.50312650
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49735233
64chromatin remodeling at centromere (GO:0031055)3.46493011
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44853548
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44853548
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.43308330
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.43308330
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.43308330
70positive regulation of ligase activity (GO:0051351)3.42675699
71cellular component biogenesis (GO:0044085)3.40661332
72telomere maintenance via telomere lengthening (GO:0010833)3.40617519
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.38348939
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38348939
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.38045716
76deoxyribose phosphate biosynthetic process (GO:0046385)3.35788102
772-deoxyribonucleotide biosynthetic process (GO:0009265)3.35788102
78protein targeting to membrane (GO:0006612)3.33987491
79pseudouridine synthesis (GO:0001522)3.33915117
80ATP biosynthetic process (GO:0006754)3.32989871
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.31659663
82kinetochore organization (GO:0051383)3.31301025
83DNA damage response, detection of DNA damage (GO:0042769)3.28408011
84negative regulation of RNA splicing (GO:0033119)3.27606860
85pyrimidine nucleotide catabolic process (GO:0006244)3.26672209
86ribosome biogenesis (GO:0042254)3.26566166
87purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24518048
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21011390
89kinetochore assembly (GO:0051382)3.20954700
90mitochondrial transport (GO:0006839)3.19086968
91purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.18904433
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.18317448
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17852873
94mitotic metaphase plate congression (GO:0007080)3.17006706
95termination of RNA polymerase III transcription (GO:0006386)3.16175820
96transcription elongation from RNA polymerase III promoter (GO:0006385)3.16175820
97nucleobase-containing small molecule interconversion (GO:0015949)3.09825923
98regulation of ligase activity (GO:0051340)3.09508164
99establishment of integrated proviral latency (GO:0075713)3.09222144
100transcription from mitochondrial promoter (GO:0006390)3.08465658
101viral mRNA export from host cell nucleus (GO:0046784)3.08006240
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07547986
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05859725
104spliceosomal complex assembly (GO:0000245)3.05506946
105DNA replication-independent nucleosome organization (GO:0034724)3.02225305
106DNA replication-independent nucleosome assembly (GO:0006336)3.02225305
107transcription-coupled nucleotide-excision repair (GO:0006283)2.99207660
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95562826
109rRNA modification (GO:0000154)2.92988049
110ribosome assembly (GO:0042255)2.90909426
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89438594
112termination of RNA polymerase II transcription (GO:0006369)2.88238371
113protein localization to kinetochore (GO:0034501)2.87682129
114nucleobase biosynthetic process (GO:0046112)2.85803240
115RNA splicing, via transesterification reactions (GO:0000375)2.82894736
116mRNA splicing, via spliceosome (GO:0000398)2.82204540
117RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82204540
118protein localization to chromosome, centromeric region (GO:0071459)2.81026260
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80008659
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.79957881
121metaphase plate congression (GO:0051310)2.79828979
122negative regulation of mRNA processing (GO:0050686)2.79532593
123positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79198674
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79176995
125folic acid-containing compound biosynthetic process (GO:0009396)2.78668875
126purine nucleobase biosynthetic process (GO:0009113)2.78383644
127DNA double-strand break processing (GO:0000729)2.76289143
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75412520
129DNA-templated transcription, termination (GO:0006353)2.74082093
130ncRNA processing (GO:0034470)2.72873273
131histone mRNA metabolic process (GO:0008334)2.69769282
132ribonucleoprotein complex assembly (GO:0022618)2.68173697
133histone exchange (GO:0043486)2.67413454
134maturation of 5.8S rRNA (GO:0000460)2.65570888
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.65111605
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65035780
137negative regulation of ligase activity (GO:0051352)2.65035780
138pteridine-containing compound biosynthetic process (GO:0042559)2.61641634
139telomere organization (GO:0032200)2.61462866
140telomere maintenance (GO:0000723)2.61298614
1417-methylguanosine mRNA capping (GO:0006370)2.60305272
142ncRNA metabolic process (GO:0034660)2.59021947
143G1/S transition of mitotic cell cycle (GO:0000082)2.58763154
144cell cycle G1/S phase transition (GO:0044843)2.58763154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.71699149
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30404694
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92462206
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26616057
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24609387
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.20596808
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13552462
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11219383
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97880546
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97221205
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.96506904
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88078750
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84766577
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81523965
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78077049
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76284351
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57796025
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57461412
19XRN2_22483619_ChIP-Seq_HELA_Human2.50901870
20* VDR_23849224_ChIP-Seq_CD4+_Human2.50864216
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40009802
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36049153
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33791272
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18057835
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16219928
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16047048
27FOXP3_21729870_ChIP-Seq_TREG_Human2.14642171
28DCP1A_22483619_ChIP-Seq_HELA_Human2.13882224
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03219659
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99880736
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92860425
32TTF2_22483619_ChIP-Seq_HELA_Human1.89752382
33* GABP_19822575_ChIP-Seq_HepG2_Human1.87649404
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80266436
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.75798465
36MYC_22102868_ChIP-Seq_BL_Human1.70969400
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68283895
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.68220038
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67572648
40AR_21909140_ChIP-Seq_LNCAP_Human1.64526941
41CIITA_25753668_ChIP-Seq_RAJI_Human1.63791039
42ELK1_19687146_ChIP-ChIP_HELA_Human1.63597731
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62259488
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59608932
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59298522
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56140206
47ZNF263_19887448_ChIP-Seq_K562_Human1.53468941
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53095140
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.52795519
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51488998
51VDR_21846776_ChIP-Seq_THP-1_Human1.51240783
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50287373
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49810694
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49773432
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49451293
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45861309
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.45073404
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.44724915
59* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43029924
60KDM5A_27292631_Chip-Seq_BREAST_Human1.38389668
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37637083
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27806764
63MYC_18940864_ChIP-ChIP_HL60_Human1.25213452
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24451238
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22006213
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17230247
67* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16995335
68* SPI1_23547873_ChIP-Seq_NB4_Human1.15521072
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15393925
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15068332
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14158005
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11250424
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10500195
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09568830
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07212227
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.06645484
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06580288
78* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06414030
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06226056
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05109599
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05077327
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05025191
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02912544
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01970460
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00683022
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00498468
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99288804
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99049782
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98845355
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97632640
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96524139
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94939194
93MAF_26560356_Chip-Seq_TH1_Human0.94459962
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94201717
95* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92783188
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.91926029
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90572279
98MAF_26560356_Chip-Seq_TH2_Human0.90034288
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89799145
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88965444
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88939597
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88696592
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87274313
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86958438
105UTX_26944678_Chip-Seq_JUKART_Human0.86753132
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86666427
107FOXP1_21924763_ChIP-Seq_HESCs_Human0.85618601
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85228712
109TFEB_21752829_ChIP-Seq_HELA_Human0.84850108
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84514675
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.83089549
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82891307
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82874815
114* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81390192
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81072937
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80297764
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78570594
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76556634
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72519775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87651369
2MP0004957_abnormal_blastocyst_morpholog3.81336080
3MP0010094_abnormal_chromosome_stability3.70947264
4MP0003077_abnormal_cell_cycle3.27398300
5MP0003111_abnormal_nucleus_morphology3.18183408
6MP0008057_abnormal_DNA_replication3.06281432
7MP0009379_abnormal_foot_pigmentation3.00908516
8MP0008058_abnormal_DNA_repair2.92391295
9MP0009697_abnormal_copulation2.91056018
10MP0002396_abnormal_hematopoietic_system2.45235575
11MP0000490_abnormal_crypts_of2.44400685
12MP0003763_abnormal_thymus_physiology2.33282063
13MP0008007_abnormal_cellular_replicative2.26437166
14MP0008932_abnormal_embryonic_tissue2.22196013
15MP0009333_abnormal_splenocyte_physiolog2.14084850
16MP0000685_abnormal_immune_system1.93197513
17MP0002132_abnormal_respiratory_system1.92808720
18MP0001529_abnormal_vocalization1.86343420
19MP0003136_yellow_coat_color1.85285505
20MP0006292_abnormal_olfactory_placode1.84567360
21MP0002277_abnormal_respiratory_mucosa1.75960975
22MP0005671_abnormal_response_to1.74522832
23MP0000358_abnormal_cell_content/1.72144634
24MP0002398_abnormal_bone_marrow1.69294660
25MP0002877_abnormal_melanocyte_morpholog1.64606463
26MP0000350_abnormal_cell_proliferation1.64013618
27MP0001730_embryonic_growth_arrest1.60152478
28MP0002019_abnormal_tumor_incidence1.59032426
29MP0002938_white_spotting1.55983024
30MP0000689_abnormal_spleen_morphology1.55579005
31MP0003786_premature_aging1.54774026
32MP0002722_abnormal_immune_system1.54072060
33MP0002166_altered_tumor_susceptibility1.52263226
34MP0001800_abnormal_humoral_immune1.51103881
35MP0000703_abnormal_thymus_morphology1.51070379
36MP0001873_stomach_inflammation1.48671593
37MP0001835_abnormal_antigen_presentation1.46793087
38MP0002160_abnormal_reproductive_system1.44156915
39MP0003806_abnormal_nucleotide_metabolis1.42496691
40MP0010030_abnormal_orbit_morphology1.42219180
41MP0003941_abnormal_skin_development1.41874590
42MP0003123_paternal_imprinting1.41749698
43MP0003718_maternal_effect1.41305020
44MP0001727_abnormal_embryo_implantation1.38278013
45MP0001764_abnormal_homeostasis1.37991820
46MP0000372_irregular_coat_pigmentation1.37763124
47MP0000313_abnormal_cell_death1.37303524
48MP0000716_abnormal_immune_system1.36165164
49MP0002429_abnormal_blood_cell1.34435619
50MP0002638_abnormal_pupillary_reflex1.32717002
51MP0002420_abnormal_adaptive_immunity1.26526208
52MP0001819_abnormal_immune_cell1.25124259
53MP0006036_abnormal_mitochondrial_physio1.23262189
54MP0008877_abnormal_DNA_methylation1.22485374
55MP0002009_preneoplasia1.21995096
56MP0005501_abnormal_skin_physiology1.21187489
57MP0002452_abnormal_antigen_presenting1.20608350
58MP0002723_abnormal_immune_serum1.20396259
59MP0009785_altered_susceptibility_to1.20158529
60MP0001697_abnormal_embryo_size1.19707433
61MP0004808_abnormal_hematopoietic_stem1.18933814
62MP0010155_abnormal_intestine_physiology1.18794702
63MP0008789_abnormal_olfactory_epithelium1.18005783
64MP0001881_abnormal_mammary_gland1.17771330
65MP0002080_prenatal_lethality1.12254082
66MP0001542_abnormal_bone_strength1.11693367
67MP0005499_abnormal_olfactory_system1.11489887
68MP0005394_taste/olfaction_phenotype1.11489887
69MP0002006_tumorigenesis1.10549971
70MP0001905_abnormal_dopamine_level1.10053942
71MP0005389_reproductive_system_phenotype1.08314882
72MP0005025_abnormal_response_to1.06308498
73MP0003186_abnormal_redox_activity1.05444297
74MP0005174_abnormal_tail_pigmentation1.05427125
75MP0004381_abnormal_hair_follicle1.04182797
76MP0002405_respiratory_system_inflammati1.03458562
77MP0003436_decreased_susceptibility_to1.02914817
78MP0001853_heart_inflammation1.01620656
79MP0001919_abnormal_reproductive_system1.00732865
80MP0005397_hematopoietic_system_phenotyp1.00302575
81MP0001545_abnormal_hematopoietic_system1.00302575
82MP0000858_altered_metastatic_potential1.00236252
83MP0005000_abnormal_immune_tolerance0.99838141
84MP0001672_abnormal_embryogenesis/_devel0.99563227
85MP0005380_embryogenesis_phenotype0.99563227
86MP0003866_abnormal_defecation0.99022884
87MP0005084_abnormal_gallbladder_morpholo0.95884951
88MP0008875_abnormal_xenobiotic_pharmacok0.95326650
89MP0002095_abnormal_skin_pigmentation0.94292972
90MP0005387_immune_system_phenotype0.93085721
91MP0001790_abnormal_immune_system0.93085721
92MP0001293_anophthalmia0.93002732
93MP0002085_abnormal_embryonic_tissue0.91132051
94MP0005075_abnormal_melanosome_morpholog0.89691696
95MP0003567_abnormal_fetal_cardiomyocyte0.89072149
96MP0003221_abnormal_cardiomyocyte_apopto0.88733546
97MP0003984_embryonic_growth_retardation0.88527376
98MP0000477_abnormal_intestine_morphology0.87831624
99MP0000465_gastrointestinal_hemorrhage0.87789811
100MP0002088_abnormal_embryonic_growth/wei0.85976440
101MP0008995_early_reproductive_senescence0.83716986
102MP0001929_abnormal_gametogenesis0.83531671
103MP0002086_abnormal_extraembryonic_tissu0.83519645
104MP0010352_gastrointestinal_tract_polyps0.83394496
105MP0002210_abnormal_sex_determination0.82361768
106MP0003724_increased_susceptibility_to0.82361316
107MP0009046_muscle_twitch0.82174954
108MP0002163_abnormal_gland_morphology0.81697769
109MP0003315_abnormal_perineum_morphology0.81652130
110MP0003656_abnormal_erythrocyte_physiolo0.81377074
111MP0006072_abnormal_retinal_apoptosis0.80234355
112MP0000613_abnormal_salivary_gland0.79046384
113MP0004147_increased_porphyrin_level0.78317326
114MP0001145_abnormal_male_reproductive0.78103324
115MP0002138_abnormal_hepatobiliary_system0.77672931
116MP0004142_abnormal_muscle_tone0.76701221
117MP0006035_abnormal_mitochondrial_morpho0.76425494
118MP0005384_cellular_phenotype0.74085144
119MP0002098_abnormal_vibrissa_morphology0.73989480
120MP0003385_abnormal_body_wall0.73280197
121MP0001186_pigmentation_phenotype0.72244396
122MP0008873_increased_physiological_sensi0.72184685
123MP0005330_cardiomyopathy0.72174664
124MP0005636_abnormal_mineral_homeostasis0.72029388
125MP0002084_abnormal_developmental_patter0.71150764
126MP0005408_hypopigmentation0.70043101
127MP0004197_abnormal_fetal_growth/weight/0.68591649
128MP0000653_abnormal_sex_gland0.68462612
129MP0003121_genomic_imprinting0.67554608
130MP0001188_hyperpigmentation0.65519904
131MP0001663_abnormal_digestive_system0.65199473
132MP0001845_abnormal_inflammatory_respons0.64120994
133MP0000566_synostosis0.62784092
134MP0010307_abnormal_tumor_latency0.62193133
135MP0000049_abnormal_middle_ear0.58929802
136MP0002177_abnormal_outer_ear0.57426255
137MP0005410_abnormal_fertilization0.57373956
138MP0002234_abnormal_pharynx_morphology0.54894617
139MP0002148_abnormal_hypersensitivity_rea0.53997091
140MP0000343_altered_response_to0.53560757
141MP0005379_endocrine/exocrine_gland_phen0.52592142
142MP0005266_abnormal_metabolism0.51787716
143MP0005253_abnormal_eye_physiology0.50333664
144MP0005332_abnormal_amino_acid0.49685474
145MP0000627_abnormal_mammary_gland0.48845257
146MP0001984_abnormal_olfaction0.46306626
147MP0009765_abnormal_xenobiotic_induced0.45713779

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.67719832
2Abnormal number of erythroid precursors (HP:0012131)6.16768239
3Reticulocytopenia (HP:0001896)5.32905557
4Macrocytic anemia (HP:0001972)4.62748800
5Increased intramyocellular lipid droplets (HP:0012240)4.60590236
6Aplastic anemia (HP:0001915)4.21428640
7Renal Fanconi syndrome (HP:0001994)4.05233708
8Pallor (HP:0000980)4.00775136
9Increased muscle lipid content (HP:0009058)3.88915695
10Oral leukoplakia (HP:0002745)3.68941739
11Breast hypoplasia (HP:0003187)3.41507470
12Increased serum pyruvate (HP:0003542)3.38423453
13Birth length less than 3rd percentile (HP:0003561)3.34283884
14Respiratory failure (HP:0002878)3.27838859
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.18141769
16Leukodystrophy (HP:0002415)3.16130323
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13105427
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13105427
19IgM deficiency (HP:0002850)2.96493221
20Colon cancer (HP:0003003)2.95962337
21Microretrognathia (HP:0000308)2.95920767
22Abnormality of glycolysis (HP:0004366)2.93048808
23Hepatocellular necrosis (HP:0001404)2.87978723
24Acute necrotizing encephalopathy (HP:0006965)2.85772778
25Thrombocytosis (HP:0001894)2.75650583
26Pustule (HP:0200039)2.71976464
27Mitochondrial inheritance (HP:0001427)2.71722851
28Absent thumb (HP:0009777)2.71261959
29Progressive muscle weakness (HP:0003323)2.66895366
30Abnormal mitochondria in muscle tissue (HP:0008316)2.64761630
31Abnormal glycosylation (HP:0012345)2.63989416
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63989416
33Abnormal protein N-linked glycosylation (HP:0012347)2.63989416
34Abnormal protein glycosylation (HP:0012346)2.63989416
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63418647
36Reduced antithrombin III activity (HP:0001976)2.62313058
37Hepatic necrosis (HP:0002605)2.59338665
38Optic disc pallor (HP:0000543)2.59079868
39Lethargy (HP:0001254)2.55155410
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55001901
41Abnormality of alanine metabolism (HP:0010916)2.55001901
42Hyperalaninemia (HP:0003348)2.55001901
43IgG deficiency (HP:0004315)2.47804818
44Increased CSF lactate (HP:0002490)2.47699757
45Exertional dyspnea (HP:0002875)2.47584392
46Multiple enchondromatosis (HP:0005701)2.46152148
47Acute encephalopathy (HP:0006846)2.43055893
48Testicular atrophy (HP:0000029)2.42368681
49Rough bone trabeculation (HP:0100670)2.42231041
50Type I transferrin isoform profile (HP:0003642)2.42113111
51Abnormality of renal resorption (HP:0011038)2.40028688
52Increased serum lactate (HP:0002151)2.37203509
53Patellar aplasia (HP:0006443)2.37110600
54Abnormality of the preputium (HP:0100587)2.35057946
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.34850180
56Methylmalonic aciduria (HP:0012120)2.34165935
57Aplasia/Hypoplasia of the patella (HP:0006498)2.33487762
58Trismus (HP:0000211)2.32161173
59Abnormality of T cells (HP:0002843)2.30352936
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28359879
61Pancytopenia (HP:0001876)2.28126582
62CNS demyelination (HP:0007305)2.26533866
63Abnormality of T cell physiology (HP:0011840)2.25266303
64Cerebral hypomyelination (HP:0006808)2.24582834
65Hypoplasia of the radius (HP:0002984)2.23972248
66Abnormal hemoglobin (HP:0011902)2.23724658
67Lymphoma (HP:0002665)2.22294849
68Muscle fiber atrophy (HP:0100295)2.21652505
69X-linked dominant inheritance (HP:0001423)2.20936037
70Abnormal number of incisors (HP:0011064)2.20531897
71Basal cell carcinoma (HP:0002671)2.18835016
72Increased hepatocellular lipid droplets (HP:0006565)2.16680559
73Poikiloderma (HP:0001029)2.15553711
74Emotional lability (HP:0000712)2.14667312
75Methylmalonic acidemia (HP:0002912)2.13394466
763-Methylglutaconic aciduria (HP:0003535)2.13053190
77Panhypogammaglobulinemia (HP:0003139)2.12440498
78Progressive macrocephaly (HP:0004481)2.12226647
79T lymphocytopenia (HP:0005403)2.11491359
80Myelodysplasia (HP:0002863)2.11391406
8111 pairs of ribs (HP:0000878)2.08706433
82Premature graying of hair (HP:0002216)2.08313755
83Ragged-red muscle fibers (HP:0003200)2.04132382
84Microcytic anemia (HP:0001935)2.03355026
85Triphalangeal thumb (HP:0001199)2.02394628
86Exercise intolerance (HP:0003546)2.02343977
87Asplenia (HP:0001746)2.01669418
88Abnormality of chromosome stability (HP:0003220)2.00803986
89Abnormality of reticulocytes (HP:0004312)2.00418528
90Type 2 muscle fiber atrophy (HP:0003554)1.99837142
91Generalized aminoaciduria (HP:0002909)1.99631768
92Medulloblastoma (HP:0002885)1.98106633
93Agammaglobulinemia (HP:0004432)1.97026327
94Abnormality of T cell number (HP:0011839)1.96745375
95Stenosis of the external auditory canal (HP:0000402)1.95791510
96Meckel diverticulum (HP:0002245)1.95248626
97Abnormality of B cell number (HP:0010975)1.94409592
98B lymphocytopenia (HP:0010976)1.94409592
99Carpal bone hypoplasia (HP:0001498)1.94351427
100Abnormality of the ileum (HP:0001549)1.93748430
101Respiratory difficulties (HP:0002880)1.92974112
102Abnormality of serum amino acid levels (HP:0003112)1.92807026
103Aplasia/Hypoplasia of the thymus (HP:0010515)1.92037700
104Recurrent bronchitis (HP:0002837)1.91709155
105Hyperglycinemia (HP:0002154)1.91659799
106Lipid accumulation in hepatocytes (HP:0006561)1.91445084
107Neoplasm of the pancreas (HP:0002894)1.91433883
108Lactic acidosis (HP:0003128)1.90711471
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90132061
110Dicarboxylic aciduria (HP:0003215)1.90132061
111Bone marrow hypocellularity (HP:0005528)1.88481265
112Hyperphosphaturia (HP:0003109)1.88276625
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87747086
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.87155788
115Chronic otitis media (HP:0000389)1.86716639
116Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86712644
117Abnormality of urine glucose concentration (HP:0011016)1.84769217
118Glycosuria (HP:0003076)1.84769217
119Microvesicular hepatic steatosis (HP:0001414)1.84086350
120Cellular immunodeficiency (HP:0005374)1.83831368
121Progressive microcephaly (HP:0000253)1.83632024
122Cleft eyelid (HP:0000625)1.83591966
123Glossoptosis (HP:0000162)1.78899138
124Combined immunodeficiency (HP:0005387)1.78847319
125Gliosis (HP:0002171)1.78293181
126Severe combined immunodeficiency (HP:0004430)1.77818953
127Recurrent viral infections (HP:0004429)1.77724867
128Abnormality of the anterior horn cell (HP:0006802)1.77201509
129Degeneration of anterior horn cells (HP:0002398)1.77201509
130Elevated erythrocyte sedimentation rate (HP:0003565)1.77012244
131Chromsome breakage (HP:0040012)1.76092717
132Cerebral edema (HP:0002181)1.76046792
133Abnormality of placental membranes (HP:0011409)1.76040365
134Amniotic constriction ring (HP:0009775)1.76040365
135Premature ovarian failure (HP:0008209)1.75815678
136Abnormality of methionine metabolism (HP:0010901)1.75575118
137Entropion (HP:0000621)1.75146221
138Squamous cell carcinoma (HP:0002860)1.74272609
139Sparse eyelashes (HP:0000653)1.74094133
140Meningitis (HP:0001287)1.73635919
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.73607811
142Palpitations (HP:0001962)1.65382094
143Vomiting (HP:0002013)1.64928774
144Hypertensive crisis (HP:0100735)1.63596369
145Abnormality of the tricuspid valve (HP:0001702)1.61366254
146Megaloblastic anemia (HP:0001889)1.60983462
147Aplasia/hypoplasia of the uterus (HP:0008684)1.57988385
148Blindness (HP:0000618)1.57876718
149Opisthotonus (HP:0002179)1.57624063
150Gout (HP:0001997)1.54551740
151Abnormal umbilical cord blood vessels (HP:0011403)1.54092780
152Single umbilical artery (HP:0001195)1.54092780
153Abnormality of the fetal cardiovascular system (HP:0010948)1.54092780
154Death in infancy (HP:0001522)1.52210341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.50670376
2VRK24.04783235
3NME23.96660953
4BUB13.76578135
5TLK13.33419384
6WEE13.28707324
7CDC73.00941528
8SCYL22.63342774
9MAP3K102.51153279
10DYRK32.46141050
11EIF2AK12.41370970
12STK162.39324440
13ACVR1B2.31034702
14NEK22.20765963
15ARAF2.18097545
16MAP4K12.13660824
17PBK2.12909260
18TESK12.07781049
19VRK12.01666105
20MAP3K121.97736756
21SRPK11.95925943
22PDK21.82336067
23EIF2AK31.77821211
24ZAK1.68496912
25BRSK21.58830715
26MKNK21.57396172
27RPS6KA41.51236879
28NME11.48221343
29LIMK11.45734141
30MKNK11.45126751
31RPS6KB21.44931690
32AURKB1.41455199
33PLK41.39361252
34CDK41.35676989
35TESK21.34734490
36PLK11.34330008
37CDK71.31980086
38PIM21.31590943
39ABL21.30066141
40TEC1.19180311
41MST41.11378316
42KDR1.09078952
43AURKA1.08353959
44NLK1.07861853
45NUAK11.03596606
46CHEK21.03238458
47BCKDK1.01995371
48STK41.00861197
49MAP4K21.00009213
50STK100.99385803
51CLK10.98153600
52LRRK20.98018306
53TAF10.96295662
54TTK0.95006724
55MAP3K110.91801199
56PIM10.90876625
57BLK0.90136041
58CSNK1G20.89038237
59MAP2K70.88855233
60GRK60.88417214
61CSNK1A1L0.87305147
62ATR0.85681383
63NEK10.85579014
64MAP3K80.84569182
65WNK40.84153280
66MAP2K30.83728701
67IRAK40.82453325
68TXK0.82406279
69BTK0.80185382
70ZAP700.77412274
71DAPK10.75485391
72TRIM280.72775901
73TGFBR10.71329296
74CSNK2A10.69775120
75TYK20.69631573
76RPS6KA50.69080346
77PASK0.67478115
78BRSK10.66538238
79CSNK2A20.66221908
80CDK30.66116450
81BCR0.63047752
82CHEK10.62893042
83CCNB10.61912276
84CDK80.58436646
85DAPK30.57983452
86MAP2K20.57941107
87ILK0.57509751
88DYRK20.57329313
89MOS0.56952168
90CDK140.56103803
91TSSK60.55859870
92CSNK1E0.55760670
93PLK30.55723499
94EIF2AK20.52614210
95CDK20.50584004
96IRAK10.50193546
97CDK11A0.50108388
98CSK0.49553658
99LYN0.48242447
100KIT0.47639685
101IKBKB0.47469697
102PAK10.45670115
103IRAK30.43276984
104CDK60.43056498
105HIPK20.42853278
106CDK150.41683712
107ALK0.41368906
108ATM0.40915914
109SYK0.40738942
110CDK180.40591227
111DYRK1B0.39973443
112PRKCI0.39252149
113JAK30.38983321
114MELK0.38785085
115CSNK1G10.37260165
116CSNK1G30.36656602
117MARK30.36578499
118CDK10.36391219
119CDK90.36257121
120PRKG20.36222258
121TAOK20.35836973
122AKT20.35526228
123MAPKAPK30.34315369
124EEF2K0.34149625
125PAK40.34011590
126MAP2K60.33913183
127STK240.33476420
128MYLK0.33068469
129ERBB40.32951034
130MAPK110.32232873
131LCK0.31675391
132MAP3K50.30926649
133MINK10.30256099
134MAPK40.30070783
135CSNK1A10.29898616
136BRAF0.29888936
137MAPKAPK50.25160924

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.58846119
2DNA replication_Homo sapiens_hsa030304.58192708
3Mismatch repair_Homo sapiens_hsa034303.75678474
4Spliceosome_Homo sapiens_hsa030403.28626045
5RNA polymerase_Homo sapiens_hsa030203.24559411
6Proteasome_Homo sapiens_hsa030503.12545380
7Base excision repair_Homo sapiens_hsa034103.04766024
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04401706
9Homologous recombination_Homo sapiens_hsa034402.85210757
10RNA transport_Homo sapiens_hsa030132.49136516
11Nucleotide excision repair_Homo sapiens_hsa034202.46816577
12Pyrimidine metabolism_Homo sapiens_hsa002402.44057835
13Cell cycle_Homo sapiens_hsa041102.01258595
14Sulfur relay system_Homo sapiens_hsa041221.91479819
15Fanconi anemia pathway_Homo sapiens_hsa034601.82394144
16One carbon pool by folate_Homo sapiens_hsa006701.76075486
17Primary immunodeficiency_Homo sapiens_hsa053401.70594952
18Basal transcription factors_Homo sapiens_hsa030221.67715983
19Non-homologous end-joining_Homo sapiens_hsa034501.67101530
20Protein export_Homo sapiens_hsa030601.65585728
21RNA degradation_Homo sapiens_hsa030181.59091014
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57755706
23Folate biosynthesis_Homo sapiens_hsa007901.55796716
24Parkinsons disease_Homo sapiens_hsa050121.54117119
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49422308
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47471573
27Oxidative phosphorylation_Homo sapiens_hsa001901.46408175
28Systemic lupus erythematosus_Homo sapiens_hsa053221.45101454
29Huntingtons disease_Homo sapiens_hsa050161.23653244
30p53 signaling pathway_Homo sapiens_hsa041151.23627278
31mRNA surveillance pathway_Homo sapiens_hsa030151.22164349
32Purine metabolism_Homo sapiens_hsa002301.21901370
33Pyruvate metabolism_Homo sapiens_hsa006201.11396524
34Herpes simplex infection_Homo sapiens_hsa051681.10919964
35Epstein-Barr virus infection_Homo sapiens_hsa051690.99045634
36Fatty acid elongation_Homo sapiens_hsa000620.98784449
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97986454
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96006731
39Antigen processing and presentation_Homo sapiens_hsa046120.94290881
40Pentose phosphate pathway_Homo sapiens_hsa000300.91889949
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.88245408
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87668049
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87111420
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.82993350
45Alzheimers disease_Homo sapiens_hsa050100.79654789
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.79502947
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77997541
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74809928
49Thyroid cancer_Homo sapiens_hsa052160.69219730
50Propanoate metabolism_Homo sapiens_hsa006400.68640614
51Viral carcinogenesis_Homo sapiens_hsa052030.64062343
52Glutathione metabolism_Homo sapiens_hsa004800.64026480
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63705999
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62317820
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62072617
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.61750596
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61318626
58Sulfur metabolism_Homo sapiens_hsa009200.60986182
59Measles_Homo sapiens_hsa051620.57003521
60Biosynthesis of amino acids_Homo sapiens_hsa012300.54791570
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.53994363
62Selenocompound metabolism_Homo sapiens_hsa004500.53100222
63HTLV-I infection_Homo sapiens_hsa051660.50461477
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48821449
65Vitamin B6 metabolism_Homo sapiens_hsa007500.48451604
66Alcoholism_Homo sapiens_hsa050340.46817303
67Collecting duct acid secretion_Homo sapiens_hsa049660.45596526
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45088679
69Renin-angiotensin system_Homo sapiens_hsa046140.44502175
70Vibrio cholerae infection_Homo sapiens_hsa051100.43045329
71Steroid biosynthesis_Homo sapiens_hsa001000.42961340
72Regulation of autophagy_Homo sapiens_hsa041400.42868919
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42642714
74Peroxisome_Homo sapiens_hsa041460.41922365
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41782860
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41399872
77Metabolic pathways_Homo sapiens_hsa011000.40970603
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40464482
79B cell receptor signaling pathway_Homo sapiens_hsa046620.37937391
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37591513
81Allograft rejection_Homo sapiens_hsa053300.36138562
82Hematopoietic cell lineage_Homo sapiens_hsa046400.36090043
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34664093
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34545583
85Apoptosis_Homo sapiens_hsa042100.33190171
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32830784
87Acute myeloid leukemia_Homo sapiens_hsa052210.31859333
88Fructose and mannose metabolism_Homo sapiens_hsa000510.31307900
89Carbon metabolism_Homo sapiens_hsa012000.30967403
90T cell receptor signaling pathway_Homo sapiens_hsa046600.30928715
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30817334
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29780718
93Shigellosis_Homo sapiens_hsa051310.28505085
94Asthma_Homo sapiens_hsa053100.27830664
95Hepatitis B_Homo sapiens_hsa051610.26873152
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25814023
97Arachidonic acid metabolism_Homo sapiens_hsa005900.25469860
98Oocyte meiosis_Homo sapiens_hsa041140.25211924
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23926397
100Tyrosine metabolism_Homo sapiens_hsa003500.23857568
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.23264299
102Rheumatoid arthritis_Homo sapiens_hsa053230.22597529
103Notch signaling pathway_Homo sapiens_hsa043300.22376885
104Legionellosis_Homo sapiens_hsa051340.21990745
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21045963
106beta-Alanine metabolism_Homo sapiens_hsa004100.20887818
107Arginine and proline metabolism_Homo sapiens_hsa003300.20134738
108Linoleic acid metabolism_Homo sapiens_hsa005910.19627966
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19613900
110Autoimmune thyroid disease_Homo sapiens_hsa053200.19407234
111Phenylalanine metabolism_Homo sapiens_hsa003600.18313329
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17523763
113Graft-versus-host disease_Homo sapiens_hsa053320.17070860
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16901904
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.15795369
116Chemical carcinogenesis_Homo sapiens_hsa052040.15132591
117Leishmaniasis_Homo sapiens_hsa051400.14977495
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.13795223
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13699093
120Small cell lung cancer_Homo sapiens_hsa052220.13613271
121N-Glycan biosynthesis_Homo sapiens_hsa005100.12741312
122Cardiac muscle contraction_Homo sapiens_hsa042600.12075412
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11535775
124African trypanosomiasis_Homo sapiens_hsa051430.10758065
125Galactose metabolism_Homo sapiens_hsa000520.10675986
126Fatty acid metabolism_Homo sapiens_hsa012120.10585784
127Viral myocarditis_Homo sapiens_hsa054160.10126857
128Salmonella infection_Homo sapiens_hsa051320.07028475
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.06974936
130Type I diabetes mellitus_Homo sapiens_hsa049400.05508671

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