NOL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.85091174
2nuclear pore complex assembly (GO:0051292)6.05765937
3nuclear pore organization (GO:0006999)5.72953679
4cilium or flagellum-dependent cell motility (GO:0001539)5.65600411
5male meiosis (GO:0007140)5.52251953
6synapsis (GO:0007129)5.18229358
7synaptonemal complex assembly (GO:0007130)5.06414991
8synaptonemal complex organization (GO:0070193)4.99991745
9DNA methylation involved in gamete generation (GO:0043046)4.97369980
10pore complex assembly (GO:0046931)4.68618023
11mitotic metaphase plate congression (GO:0007080)4.50516589
12mitotic sister chromatid cohesion (GO:0007064)4.42154910
13monoubiquitinated protein deubiquitination (GO:0035520)4.41445016
14meiotic nuclear division (GO:0007126)4.21878716
15male meiosis I (GO:0007141)4.20337558
16chromosome organization involved in meiosis (GO:0070192)4.20122934
17metaphase plate congression (GO:0051310)4.17456614
18regulation of centriole replication (GO:0046599)4.13787770
19meiotic chromosome segregation (GO:0045132)4.11579467
20binding of sperm to zona pellucida (GO:0007339)4.07732402
21histone exchange (GO:0043486)4.01794282
22regulation of DNA endoreduplication (GO:0032875)4.01411749
23sperm-egg recognition (GO:0035036)3.97971288
24mitotic nuclear envelope disassembly (GO:0007077)3.97852537
25telomere maintenance via semi-conservative replication (GO:0032201)3.97526702
26gene silencing by RNA (GO:0031047)3.97020280
27centriole replication (GO:0007099)3.95345660
28fusion of sperm to egg plasma membrane (GO:0007342)3.92034177
29protein K6-linked ubiquitination (GO:0085020)3.90679780
30DNA double-strand break processing (GO:0000729)3.90190616
31regulation of meiosis I (GO:0060631)3.89596554
32regulation of histone H3-K9 methylation (GO:0051570)3.89367107
33kinetochore organization (GO:0051383)3.87208242
34protein localization to chromosome, centromeric region (GO:0071459)3.86903627
35protein localization to kinetochore (GO:0034501)3.85713659
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.83931265
37telomere maintenance via recombination (GO:0000722)3.80897740
38DNA strand elongation (GO:0022616)3.78467785
39chromatin remodeling at centromere (GO:0031055)3.77741939
40mitotic chromosome condensation (GO:0007076)3.74515953
41DNA replication-dependent nucleosome assembly (GO:0006335)3.73979279
42DNA replication-dependent nucleosome organization (GO:0034723)3.73979279
43sister chromatid cohesion (GO:0007062)3.73482259
44replication fork processing (GO:0031297)3.73459416
45nuclear envelope disassembly (GO:0051081)3.72193764
46membrane disassembly (GO:0030397)3.72193764
47proteasome assembly (GO:0043248)3.72048507
48meiotic cell cycle (GO:0051321)3.70773721
49mitotic recombination (GO:0006312)3.70557643
50attachment of spindle microtubules to kinetochore (GO:0008608)3.70255583
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.69138825
52regulation of mitotic spindle checkpoint (GO:1903504)3.69138825
53acrosome assembly (GO:0001675)3.68308030
54meiosis I (GO:0007127)3.68278923
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.67651916
56axonemal dynein complex assembly (GO:0070286)3.67159779
57mitotic sister chromatid segregation (GO:0000070)3.66615915
58spermatid development (GO:0007286)3.64463159
59establishment of chromosome localization (GO:0051303)3.62277930
60regulation of spindle organization (GO:0090224)3.59998482
61regulation of centrosome cycle (GO:0046605)3.59228955
62CENP-A containing nucleosome assembly (GO:0034080)3.57730908
63cell-cell recognition (GO:0009988)3.54870693
64rRNA methylation (GO:0031167)3.51852667
65DNA catabolic process, exonucleolytic (GO:0000738)3.49776991
66regulation of RNA export from nucleus (GO:0046831)3.48904538
67meiotic cell cycle process (GO:1903046)3.47231655
68microtubule depolymerization (GO:0007019)3.47189774
69sister chromatid segregation (GO:0000819)3.45243945
70DNA replication-independent nucleosome organization (GO:0034724)3.45216465
71DNA replication-independent nucleosome assembly (GO:0006336)3.45216465
72rRNA modification (GO:0000154)3.44839078
73double-strand break repair via homologous recombination (GO:0000724)3.41329273
74positive regulation of histone H3-K4 methylation (GO:0051571)3.40831551
75DNA replication initiation (GO:0006270)3.38151575
76nucleobase biosynthetic process (GO:0046112)3.37704535
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37276247
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37276247
79positive regulation of mitotic sister chromatid separation (GO:1901970)3.37276247
80recombinational repair (GO:0000725)3.37217443
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.36901796
82mitotic spindle checkpoint (GO:0071174)3.35851654
83positive regulation of chromosome segregation (GO:0051984)3.35074969
84double-strand break repair via nonhomologous end joining (GO:0006303)3.33816390
85non-recombinational repair (GO:0000726)3.33816390
86DNA synthesis involved in DNA repair (GO:0000731)3.31371138
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.31250582
88negative regulation of DNA repair (GO:0045738)3.27556893
89sperm motility (GO:0030317)3.27022271
90regulation of chromosome segregation (GO:0051983)3.26627878
91DNA replication checkpoint (GO:0000076)3.25707254
92heterochromatin organization (GO:0070828)3.24141154
93ribosome assembly (GO:0042255)3.23211922
94IMP biosynthetic process (GO:0006188)3.22375591
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.21542564
96negative regulation of sister chromatid segregation (GO:0033046)3.21542564
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21542564
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21542564
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21542564
100motile cilium assembly (GO:0044458)3.20420440
101multicellular organism reproduction (GO:0032504)3.20029363
102telomere maintenance via telomere lengthening (GO:0010833)3.19869089
103ribosome biogenesis (GO:0042254)3.18411238
104negative regulation of histone methylation (GO:0031061)3.17254855
105kinetochore assembly (GO:0051382)3.16946326
106regulation of mitotic sister chromatid separation (GO:0010965)3.16289970
107regulation of mitotic sister chromatid segregation (GO:0033047)3.16289970
108regulation of sister chromatid segregation (GO:0033045)3.16289970
109negative regulation of chromosome segregation (GO:0051985)3.15642489
110regulation of mitotic spindle organization (GO:0060236)3.14940602
111mitotic spindle assembly checkpoint (GO:0007094)3.14732543
112DNA alkylation (GO:0006305)3.14008246
113DNA methylation (GO:0006306)3.14008246
114spindle assembly checkpoint (GO:0071173)3.12442193
115DNA-dependent DNA replication (GO:0006261)3.12077150
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11117489
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10738386
118DNA geometric change (GO:0032392)3.09266700
119histone mRNA metabolic process (GO:0008334)3.09247885
120postreplication repair (GO:0006301)3.09180478
121DNA duplex unwinding (GO:0032508)3.08853825
122chromatin assembly or disassembly (GO:0006333)3.08813902
123translesion synthesis (GO:0019985)3.08296534
124DNA ligation (GO:0006266)3.07971708
125histone H2A acetylation (GO:0043968)3.06973317
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06319499
127purine nucleobase biosynthetic process (GO:0009113)3.05731838
128chromosome segregation (GO:0007059)3.05690404
129ATP-dependent chromatin remodeling (GO:0043044)3.04662457
130RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04089993
131DNA unwinding involved in DNA replication (GO:0006268)3.03427546
132formation of translation preinitiation complex (GO:0001731)3.03090132
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02417471
134transcription elongation from RNA polymerase I promoter (GO:0006362)3.02198631
135regulation of centrosome duplication (GO:0010824)3.01888001
136mitotic G2/M transition checkpoint (GO:0044818)3.01749944
137nucleus organization (GO:0006997)3.01302944
138maturation of 5.8S rRNA (GO:0000460)3.00859257
139spindle checkpoint (GO:0031577)3.00142371
140gene silencing (GO:0016458)3.00115007
141protein localization to chromosome (GO:0034502)2.99739578
142DNA strand elongation involved in DNA replication (GO:0006271)2.99447377
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98989490
144double-strand break repair (GO:0006302)2.98701118
145reciprocal meiotic recombination (GO:0007131)2.97986519
146reciprocal DNA recombination (GO:0035825)2.97986519
147chaperone-mediated protein complex assembly (GO:0051131)2.96861904
148DNA packaging (GO:0006323)2.95240441
149intra-S DNA damage checkpoint (GO:0031573)2.95106822
150regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94629014
151chromatin assembly (GO:0031497)2.94628288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40894132
2* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.50534297
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.45925741
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04158270
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.64493124
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35975228
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86762321
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.68632443
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51267841
10AR_21909140_ChIP-Seq_LNCAP_Human2.49660896
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45885130
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42755536
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.36957291
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.25473960
15* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.16430147
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.14010996
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13919064
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12942068
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12107315
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12044118
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11017814
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08065118
23* VDR_23849224_ChIP-Seq_CD4+_Human2.05605354
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.04715207
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01457308
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00791708
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91537244
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.90681514
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89785194
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84964250
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82891196
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.79917258
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76170119
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74595946
35DCP1A_22483619_ChIP-Seq_HELA_Human1.73681436
36* XRN2_22483619_ChIP-Seq_HELA_Human1.70033508
37ELK1_19687146_ChIP-ChIP_HELA_Human1.66199220
38GABP_19822575_ChIP-Seq_HepG2_Human1.59963400
39FUS_26573619_Chip-Seq_HEK293_Human1.56253276
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55755503
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55544968
42ZNF274_21170338_ChIP-Seq_K562_Hela1.53612495
43* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49659566
44KDM5A_27292631_Chip-Seq_BREAST_Human1.49266332
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.48281949
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47480981
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44448227
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44402397
49* TTF2_22483619_ChIP-Seq_HELA_Human1.40515185
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36428078
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.33539791
52CIITA_25753668_ChIP-Seq_RAJI_Human1.30823039
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29401971
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28780695
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26239997
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24316022
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.24039270
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22117743
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19525828
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19020622
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16757642
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14038022
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13949429
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12349696
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09882118
66MYC_22102868_ChIP-Seq_BL_Human1.09630136
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08931915
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07652068
69VDR_22108803_ChIP-Seq_LS180_Human1.07538488
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07041668
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06802338
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05232389
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05028674
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00930329
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99886886
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99263955
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94473488
78MYC_18940864_ChIP-ChIP_HL60_Human0.94198809
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93802870
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92316207
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92243213
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91439634
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89549826
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89237610
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.88397760
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85728730
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84619971
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.84375465
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84345556
90PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84114240
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83097862
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82841458
93* TFEB_21752829_ChIP-Seq_HELA_Human0.82132924
94TP53_22573176_ChIP-Seq_HFKS_Human0.81513431
95ER_23166858_ChIP-Seq_MCF-7_Human0.81041241
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80919881
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80725639
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80725639
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80725639
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.80110680
101MYB_26560356_Chip-Seq_TH2_Human0.80067400
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79250932
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78962965
104TAF15_26573619_Chip-Seq_HEK293_Human0.78466862
105* SRF_21415370_ChIP-Seq_HL-1_Mouse0.78089833
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77966450
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77594382
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.76907230
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75622101
110MYB_26560356_Chip-Seq_TH1_Human0.75512070
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75314793
112SPI1_23547873_ChIP-Seq_NB4_Human0.74722971
113ELF5_23300383_ChIP-Seq_T47D_Human0.73912293
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.73073017
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.71756291
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71746496
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71672545
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.71589728
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71543648
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70925254
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70039950
122EWS_26573619_Chip-Seq_HEK293_Human0.69583317
123* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.66911803
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.66288991
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.66190449
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65378786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.78623650
2MP0008877_abnormal_DNA_methylation5.38315560
3MP0010094_abnormal_chromosome_stability4.73702296
4MP0003693_abnormal_embryo_hatching4.57902676
5MP0003111_abnormal_nucleus_morphology3.96806991
6MP0005410_abnormal_fertilization3.88215870
7MP0004957_abnormal_blastocyst_morpholog3.70595003
8MP0003077_abnormal_cell_cycle3.62007544
9MP0008058_abnormal_DNA_repair3.48732795
10MP0001929_abnormal_gametogenesis2.91073809
11MP0008007_abnormal_cellular_replicative2.81956833
12MP0002210_abnormal_sex_determination2.74577829
13MP0003123_paternal_imprinting2.52720580
14MP0000569_abnormal_digit_pigmentation2.35619733
15MP0003698_abnormal_male_reproductive2.35192625
16MP0010307_abnormal_tumor_latency2.29958821
17MP0001145_abnormal_male_reproductive2.29346319
18MP0003786_premature_aging2.25884197
19MP0001730_embryonic_growth_arrest2.22144301
20MP0008932_abnormal_embryonic_tissue2.15027274
21MP0000653_abnormal_sex_gland2.07249334
22MP0000350_abnormal_cell_proliferation1.94153174
23MP0010352_gastrointestinal_tract_polyps1.90476703
24MP0003787_abnormal_imprinting1.90017683
25MP0002396_abnormal_hematopoietic_system1.88079893
26MP0000372_irregular_coat_pigmentation1.87738726
27MP0003806_abnormal_nucleotide_metabolis1.86783918
28MP0005174_abnormal_tail_pigmentation1.79908563
29MP0001672_abnormal_embryogenesis/_devel1.74219935
30MP0005380_embryogenesis_phenotype1.74219935
31MP0004808_abnormal_hematopoietic_stem1.72501656
32MP0003121_genomic_imprinting1.70707689
33MP0005075_abnormal_melanosome_morpholog1.68761460
34MP0000015_abnormal_ear_pigmentation1.67463709
35MP0001697_abnormal_embryo_size1.64735074
36MP0003984_embryonic_growth_retardation1.57503682
37MP0002088_abnormal_embryonic_growth/wei1.52755851
38MP0002084_abnormal_developmental_patter1.51743111
39MP0003890_abnormal_embryonic-extraembry1.47046647
40MP0002161_abnormal_fertility/fecundity1.47003908
41MP0003718_maternal_effect1.45203589
42MP0006035_abnormal_mitochondrial_morpho1.42639474
43MP0006036_abnormal_mitochondrial_physio1.42329448
44MP0002085_abnormal_embryonic_tissue1.42099760
45MP0004197_abnormal_fetal_growth/weight/1.41420774
46MP0002160_abnormal_reproductive_system1.38155100
47MP0002080_prenatal_lethality1.37883855
48MP0002086_abnormal_extraembryonic_tissu1.36588452
49MP0002095_abnormal_skin_pigmentation1.33672597
50MP0002938_white_spotting1.30465774
51MP0009697_abnormal_copulation1.28146188
52MP0005076_abnormal_cell_differentiation1.27046758
53MP0000313_abnormal_cell_death1.25534686
54MP0001661_extended_life_span1.23667928
55MP0003763_abnormal_thymus_physiology1.22955830
56MP0002019_abnormal_tumor_incidence1.17383769
57MP0005408_hypopigmentation1.13899519
58MP0001119_abnormal_female_reproductive1.12763324
59MP0002653_abnormal_ependyma_morphology1.10739387
60MP0006072_abnormal_retinal_apoptosis1.09975601
61MP0001188_hyperpigmentation1.08202268
62MP0008995_early_reproductive_senescence1.06362386
63MP0005389_reproductive_system_phenotype1.06200871
64MP0002102_abnormal_ear_morphology1.05349069
65MP0001293_anophthalmia1.04653032
66MP0003567_abnormal_fetal_cardiomyocyte1.00907267
67MP0000490_abnormal_crypts_of1.00216275
68MP0001853_heart_inflammation0.99075215
69MP0003186_abnormal_redox_activity0.97898622
70MP0000703_abnormal_thymus_morphology0.93819840
71MP0001545_abnormal_hematopoietic_system0.93558529
72MP0005397_hematopoietic_system_phenotyp0.93558529
73MP0001835_abnormal_antigen_presentation0.93099943
74MP0009672_abnormal_birth_weight0.88232302
75MP0001764_abnormal_homeostasis0.88160185
76MP0006292_abnormal_olfactory_placode0.84645827
77MP0003937_abnormal_limbs/digits/tail_de0.83997970
78MP0004264_abnormal_extraembryonic_tissu0.81044092
79MP0002009_preneoplasia0.80010646
80MP0002398_abnormal_bone_marrow0.79727478
81MP0005671_abnormal_response_to0.79637190
82MP0004381_abnormal_hair_follicle0.78665893
83MP0003699_abnormal_female_reproductive0.78614646
84MP0009703_decreased_birth_body0.77721156
85MP0005646_abnormal_pituitary_gland0.76041635
86MP0005266_abnormal_metabolism0.75619313
87MP0003656_abnormal_erythrocyte_physiolo0.74829031
88MP0008789_abnormal_olfactory_epithelium0.72789823
89MP0000427_abnormal_hair_cycle0.71907845
90MP0003646_muscle_fatigue0.70697105
91MP0003315_abnormal_perineum_morphology0.70493654
92MP0000432_abnormal_head_morphology0.70155470
93MP0001915_intracranial_hemorrhage0.70092324
94MP0005384_cellular_phenotype0.69617766
95MP0000689_abnormal_spleen_morphology0.69329067
96MP0005621_abnormal_cell_physiology0.68901599
97MP0004147_increased_porphyrin_level0.68194075
98MP0000647_abnormal_sebaceous_gland0.67653418
99MP0002722_abnormal_immune_system0.67498750
100MP0009333_abnormal_splenocyte_physiolog0.67229531
101MP0002877_abnormal_melanocyte_morpholog0.66804382
102MP0000371_diluted_coat_color0.65989262
103MP0005253_abnormal_eye_physiology0.65426493
104MP0003943_abnormal_hepatobiliary_system0.63614737
105MP0005084_abnormal_gallbladder_morpholo0.62592649
106MP0005551_abnormal_eye_electrophysiolog0.62101656
107MP0003936_abnormal_reproductive_system0.61767855
108MP0002282_abnormal_trachea_morphology0.60981047
109MP0008873_increased_physiological_sensi0.60941637
110MP0000358_abnormal_cell_content/0.60252994
111MP0003119_abnormal_digestive_system0.57841451
112MP0005647_abnormal_sex_gland0.57289242
113MP0001800_abnormal_humoral_immune0.56337058
114MP0003136_yellow_coat_color0.56282038
115MP0001919_abnormal_reproductive_system0.56099191
116MP0004134_abnormal_chest_morphology0.55798201
117MP0005395_other_phenotype0.53826841
118MP0003950_abnormal_plasma_membrane0.52691503
119MP0001286_abnormal_eye_development0.52414803
120MP0002163_abnormal_gland_morphology0.50465080
121MP0005623_abnormal_meninges_morphology0.48583045
122MP0002429_abnormal_blood_cell0.48414034
123MP0002092_abnormal_eye_morphology0.47291868
124MP0002006_tumorigenesis0.45702855
125MP0002925_abnormal_cardiovascular_devel0.45607318
126MP0003935_abnormal_craniofacial_develop0.44695158
127MP0002114_abnormal_axial_skeleton0.44199734
128MP0000428_abnormal_craniofacial_morphol0.42710925
129MP0000716_abnormal_immune_system0.42669311
130MP0003861_abnormal_nervous_system0.42095523
131MP0002166_altered_tumor_susceptibility0.41928526
132MP0000537_abnormal_urethra_morphology0.41144628
133MP0004233_abnormal_muscle_weight0.39640656
134MP0000266_abnormal_heart_morphology0.39170249

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.36530698
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.80943063
3Absent/shortened dynein arms (HP:0200106)4.80943063
4Chromsome breakage (HP:0040012)4.16680209
5Birth length less than 3rd percentile (HP:0003561)3.98691900
6Abnormality of the anterior horn cell (HP:0006802)3.97109942
7Degeneration of anterior horn cells (HP:0002398)3.97109942
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86128792
911 pairs of ribs (HP:0000878)3.78470599
10Abnormal respiratory motile cilium physiology (HP:0012261)3.74442416
11Rhinitis (HP:0012384)3.67360146
12Chronic bronchitis (HP:0004469)3.53977011
13Abnormality of chromosome stability (HP:0003220)3.44934058
14Abnormal respiratory epithelium morphology (HP:0012253)3.37321730
15Abnormal respiratory motile cilium morphology (HP:0005938)3.37321730
16Abnormal spermatogenesis (HP:0008669)3.36710467
17Supernumerary spleens (HP:0009799)3.24051674
18Impulsivity (HP:0100710)3.21813561
19Volvulus (HP:0002580)3.07059753
20Abnormality of the preputium (HP:0100587)3.03138955
21Selective tooth agenesis (HP:0001592)2.99176915
22Meckel diverticulum (HP:0002245)2.97027940
23Medulloblastoma (HP:0002885)2.96384564
24Abnormality of the lower motor neuron (HP:0002366)2.93763119
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.87252122
26Abnormality of the ileum (HP:0001549)2.81648842
27Fibular hypoplasia (HP:0003038)2.78509235
28Ectopic kidney (HP:0000086)2.76234336
29Nephroblastoma (Wilms tumor) (HP:0002667)2.72500335
30Irregular epiphyses (HP:0010582)2.71002590
31Azoospermia (HP:0000027)2.69587509
32Myelodysplasia (HP:0002863)2.67114485
33Severe combined immunodeficiency (HP:0004430)2.66289987
34B lymphocytopenia (HP:0010976)2.66268583
35Combined immunodeficiency (HP:0005387)2.64150109
36Carpal bone hypoplasia (HP:0001498)2.63624461
37Abnormality of B cell number (HP:0010975)2.63026839
38Abnormal ciliary motility (HP:0012262)2.61360932
39Papillary thyroid carcinoma (HP:0002895)2.60009304
40Missing ribs (HP:0000921)2.58652050
41Infertility (HP:0000789)2.58264764
42Sloping forehead (HP:0000340)2.58157335
43Embryonal renal neoplasm (HP:0011794)2.55975718
44Abnormality of the labia minora (HP:0012880)2.54292345
45Neoplasm of the oral cavity (HP:0100649)2.54179955
46Nephronophthisis (HP:0000090)2.52005528
47Colon cancer (HP:0003003)2.50858892
48Gonadotropin excess (HP:0000837)2.48607531
49Aplastic anemia (HP:0001915)2.48387114
50Small intestinal stenosis (HP:0012848)2.44267944
51Duodenal stenosis (HP:0100867)2.44267944
52Absent frontal sinuses (HP:0002688)2.43869596
53Bronchiectasis (HP:0002110)2.41393803
54Bronchitis (HP:0012387)2.41300414
55Methylmalonic acidemia (HP:0002912)2.41051154
56Prominent nose (HP:0000448)2.38384504
57Renal cortical cysts (HP:0000803)2.36973792
58Entropion (HP:0000621)2.36052059
59Absent epiphyses (HP:0010577)2.35774525
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35774525
61Rhabdomyosarcoma (HP:0002859)2.35224997
62Ependymoma (HP:0002888)2.33073135
63Panhypogammaglobulinemia (HP:0003139)2.32219821
64Tubulointerstitial nephritis (HP:0001970)2.31715953
65Increased CSF lactate (HP:0002490)2.31173435
66Abnormality of DNA repair (HP:0003254)2.30076457
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29979966
68Breast hypoplasia (HP:0003187)2.28892666
69Nasal polyposis (HP:0100582)2.28473598
70Patellar aplasia (HP:0006443)2.27986527
71Acute myeloid leukemia (HP:0004808)2.27016386
72Upper motor neuron abnormality (HP:0002127)2.21349935
73Acute necrotizing encephalopathy (HP:0006965)2.19017473
74Thyroiditis (HP:0100646)2.16889358
75Facial hemangioma (HP:0000329)2.16844916
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16392225
77Abnormality of alanine metabolism (HP:0010916)2.16392225
78Hyperalaninemia (HP:0003348)2.16392225
79Microvesicular hepatic steatosis (HP:0001414)2.16367168
80Agnosia (HP:0010524)2.14548225
81Abnormality of the renal cortex (HP:0011035)2.13049557
82Pancreatic cysts (HP:0001737)2.12740928
83Amyotrophic lateral sclerosis (HP:0007354)2.12461281
84Increased serum lactate (HP:0002151)2.08592062
85Oligodactyly (hands) (HP:0001180)2.08543116
86Glioma (HP:0009733)2.06975926
87Increased hepatocellular lipid droplets (HP:0006565)2.06672914
88Abnormality of methionine metabolism (HP:0010901)2.06134701
89Progressive macrocephaly (HP:0004481)2.05600547
90Aplasia/Hypoplasia of the patella (HP:0006498)2.04176245
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04026965
92Short ribs (HP:0000773)2.01982929
93Neoplasm of the colon (HP:0100273)2.01675161
94Pancreatic islet-cell hyperplasia (HP:0004510)2.01506708
95Absent thumb (HP:0009777)2.00775357
96Pancytopenia (HP:0001876)1.99882398
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.99762169
98Abnormality of the duodenum (HP:0002246)1.99743973
99Molar tooth sign on MRI (HP:0002419)1.99360616
100Abnormality of midbrain morphology (HP:0002418)1.99360616
101Biliary tract neoplasm (HP:0100574)1.97938961
102Abnormal biliary tract physiology (HP:0012439)1.97750210
103Bile duct proliferation (HP:0001408)1.97750210
104Short thumb (HP:0009778)1.96558476
105Bone marrow hypocellularity (HP:0005528)1.95958575
106Aplasia/Hypoplasia of the fibula (HP:0006492)1.94446106
107Abnormal lung lobation (HP:0002101)1.94408838
108Squamous cell carcinoma (HP:0002860)1.93732870
109Clubbing of toes (HP:0100760)1.93323980
110Male infertility (HP:0003251)1.92900133
111Abnormality of the pons (HP:0007361)1.92608106
112Abnormality of the carotid arteries (HP:0005344)1.92287185
113Acute encephalopathy (HP:0006846)1.92212500
114Premature ovarian failure (HP:0008209)1.92153434
115Breast carcinoma (HP:0003002)1.92141661
116Facial cleft (HP:0002006)1.91788802
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91486187
118IgG deficiency (HP:0004315)1.91380645
119Pancreatic fibrosis (HP:0100732)1.90971873
120Hypoplasia of the radius (HP:0002984)1.90794957
121Abnormality of the renal medulla (HP:0100957)1.88889239
122Abnormal mitochondria in muscle tissue (HP:0008316)1.88457436
123Type I transferrin isoform profile (HP:0003642)1.88348702
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.88170707
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.87607181
126Hypoplasia of the fovea (HP:0007750)1.87607181
127Cutaneous melanoma (HP:0012056)1.87556277
128Short middle phalanx of the 5th finger (HP:0004220)1.87415991
129Hypoplasia of the pons (HP:0012110)1.85936711
130Basal cell carcinoma (HP:0002671)1.84676919
131Oral leukoplakia (HP:0002745)1.84433128
132Lipid accumulation in hepatocytes (HP:0006561)1.83994322
133Methylmalonic aciduria (HP:0012120)1.83597671
134Posterior subcapsular cataract (HP:0007787)1.83395750
135Abnormality of the astrocytes (HP:0100707)1.83384222
136Astrocytoma (HP:0009592)1.83384222
137Cafe-au-lait spot (HP:0000957)1.82985643
138Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82717687
139Abnormality of femoral epiphyses (HP:0006499)1.82717687
140Abnormality of the epiphysis of the femoral head (HP:0010574)1.81602324
141Absent radius (HP:0003974)1.80570494
142Deviation of the thumb (HP:0009603)1.80248280
143Increased nuchal translucency (HP:0010880)1.80048970
144Small epiphyses (HP:0010585)1.79791646
145Mitochondrial inheritance (HP:0001427)1.78713444
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77755955
147Flattened epiphyses (HP:0003071)1.76488259
148Abnormality of the fingertips (HP:0001211)1.76148038
149Deep philtrum (HP:0002002)1.75749517
150Neoplasm of the adrenal cortex (HP:0100641)1.74026309
151Poikiloderma (HP:0001029)1.73519965
152Hepatocellular necrosis (HP:0001404)1.73260260
1533-Methylglutaconic aciduria (HP:0003535)1.72397885
154Median cleft lip (HP:0000161)1.71240724
155Cerebral edema (HP:0002181)1.69564545
156Hypoplasia of the thymus (HP:0000778)1.69300259
157Abnormality of eosinophils (HP:0001879)1.68486839
158Sensory axonal neuropathy (HP:0003390)1.68322171
159Albinism (HP:0001022)1.67738001
160Increased serum pyruvate (HP:0003542)1.67659136
161Triphalangeal thumb (HP:0001199)1.67545329
162Hepatic necrosis (HP:0002605)1.66270836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.90316395
2PDK34.55605903
3PDK44.55605903
4WEE13.50536483
5NEK23.14858374
6CDK122.99381769
7PDK22.89233345
8SRPK12.57459265
9TTK2.55421421
10ACVR1B2.43441263
11EIF2AK12.39891116
12PBK2.37779083
13BUB12.34746532
14PNCK2.21720002
15TRIM282.09804662
16BRSK22.05346452
17ATR1.93516873
18PLK41.93252499
19PLK11.90153396
20PASK1.86850894
21STK38L1.80758853
22MKNK21.78334426
23PLK31.75379856
24STK31.74768437
25CHEK21.70343208
26CHEK11.67970730
27MKNK11.66263734
28TSSK61.62074908
29VRK21.54323872
30MAP4K21.53686917
31LATS11.51456075
32AURKB1.48625141
33TAOK31.47611908
34PRKD31.44734870
35ATM1.35242942
36EIF2AK31.34994707
37CDK71.32307101
38CDK41.26643329
39TNIK1.23159735
40CCNB11.16728006
41INSRR1.11305844
42NME11.10610627
43TAF10.96445123
44CDK20.96058169
45VRK10.92886082
46RPS6KA40.91623921
47DYRK30.90778566
48STK100.89959683
49MELK0.88919969
50NEK10.86614956
51BRD40.86614933
52EEF2K0.84626414
53EPHA20.83376532
54STK40.82194610
55RPS6KB20.81390515
56PIM10.76995971
57ERBB30.76364938
58CDK10.76358816
59BRSK10.76233094
60CDK60.75614115
61MAP3K80.74997953
62TESK10.74266225
63CDK30.74012557
64AURKA0.73248964
65ZAK0.72942148
66RAF10.72899110
67NUAK10.72184557
68MAP3K30.71924060
69ALK0.70664564
70CSNK2A20.67043320
71AKT30.65290177
72STK240.64865552
73CLK10.63022087
74STK160.61919609
75TGFBR10.61420816
76SCYL20.60663144
77MTOR0.56390112
78WNK30.54675896
79CDK90.53177204
80CSNK2A10.51214681
81CSNK1E0.50893678
82RPS6KB10.49718429
83MARK30.49319903
84CSNK1D0.49046892
85PRKDC0.48885510
86CAMK1G0.47910832
87FRK0.47243381
88TLK10.46560309
89OXSR10.45441167
90LATS20.44133229
91MAP3K140.44107858
92MAP4K10.44018426
93BRAF0.43917940
94MAP3K120.43832057
95TESK20.42775261
96DMPK0.42768855
97CDK80.42645201
98JAK30.41515806
99MAPK140.41330375
100FGFR10.40662715
101NEK90.40644761
102ICK0.40440503
103PTK2B0.38293081
104TRPM70.38124514
105TXK0.35536153
106MAPK130.35502806
107NLK0.35168039
108WNK40.32789872
109GSK3B0.32106872
110WNK10.28870364
111PRKCI0.28621351
112AKT10.28037204
113MST40.27438555
114RPS6KA50.26965919
115NME20.26939066
116BMPR20.26478511
117ITK0.25423918
118CDK190.25273915
119ERBB40.25017447
120BCR0.24702294
121IRAK10.24118383
122MAPK10.24088652
123TEC0.23876424
124MAP3K50.22992414
125BMPR1B0.21942317
126EIF2AK20.20978051
127MAPK100.20152440
128PLK20.18292357
129NEK60.18086259
130STK390.17893435

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.47498034
2DNA replication_Homo sapiens_hsa030303.77187498
3RNA transport_Homo sapiens_hsa030133.74608478
4Mismatch repair_Homo sapiens_hsa034303.71279225
5Fanconi anemia pathway_Homo sapiens_hsa034603.30925696
6Basal transcription factors_Homo sapiens_hsa030223.16940501
7Homologous recombination_Homo sapiens_hsa034403.15558894
8Spliceosome_Homo sapiens_hsa030403.10614477
9RNA polymerase_Homo sapiens_hsa030203.08975210
10Cell cycle_Homo sapiens_hsa041103.07578780
11Non-homologous end-joining_Homo sapiens_hsa034502.74793234
12Nucleotide excision repair_Homo sapiens_hsa034202.60482350
13One carbon pool by folate_Homo sapiens_hsa006702.47167230
14RNA degradation_Homo sapiens_hsa030182.47021207
15mRNA surveillance pathway_Homo sapiens_hsa030152.45480966
16Base excision repair_Homo sapiens_hsa034102.37267307
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34146343
18Pyrimidine metabolism_Homo sapiens_hsa002402.19916451
19Proteasome_Homo sapiens_hsa030501.95693624
20Vitamin B6 metabolism_Homo sapiens_hsa007501.88364215
21Selenocompound metabolism_Homo sapiens_hsa004501.85505684
22p53 signaling pathway_Homo sapiens_hsa041151.67698739
23Propanoate metabolism_Homo sapiens_hsa006401.65906449
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58956508
25Oocyte meiosis_Homo sapiens_hsa041141.50968758
26Antigen processing and presentation_Homo sapiens_hsa046121.37826546
27Ribosome_Homo sapiens_hsa030101.33768163
28Purine metabolism_Homo sapiens_hsa002301.32443266
29Epstein-Barr virus infection_Homo sapiens_hsa051691.25235938
30Systemic lupus erythematosus_Homo sapiens_hsa053221.15146150
31Herpes simplex infection_Homo sapiens_hsa051681.13328498
32Viral carcinogenesis_Homo sapiens_hsa052031.09081015
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.08881849
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08083005
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05427995
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04399212
37Oxidative phosphorylation_Homo sapiens_hsa001901.02254482
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94874609
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91306109
40Parkinsons disease_Homo sapiens_hsa050120.90143256
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89754542
42Asthma_Homo sapiens_hsa053100.86448370
43HTLV-I infection_Homo sapiens_hsa051660.84985703
44Pentose phosphate pathway_Homo sapiens_hsa000300.81339100
45MicroRNAs in cancer_Homo sapiens_hsa052060.78179831
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77654678
47TGF-beta signaling pathway_Homo sapiens_hsa043500.76501058
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75619773
49Dorso-ventral axis formation_Homo sapiens_hsa043200.75286894
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70692465
51Fatty acid elongation_Homo sapiens_hsa000620.65990092
52Autoimmune thyroid disease_Homo sapiens_hsa053200.65676577
53Small cell lung cancer_Homo sapiens_hsa052220.62318758
54Regulation of autophagy_Homo sapiens_hsa041400.61411144
55Folate biosynthesis_Homo sapiens_hsa007900.60003969
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58739544
57Thyroid cancer_Homo sapiens_hsa052160.58380337
58Steroid biosynthesis_Homo sapiens_hsa001000.57318604
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56150247
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54091456
61Glucagon signaling pathway_Homo sapiens_hsa049220.52786496
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51666448
63Biosynthesis of amino acids_Homo sapiens_hsa012300.50978879
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.50401949
65Measles_Homo sapiens_hsa051620.49215662
66Pyruvate metabolism_Homo sapiens_hsa006200.47947822
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46790208
68Circadian rhythm_Homo sapiens_hsa047100.45774706
69Lysine degradation_Homo sapiens_hsa003100.45124177
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44253973
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44069854
72Legionellosis_Homo sapiens_hsa051340.43575356
73Phototransduction_Homo sapiens_hsa047440.43018309
74Influenza A_Homo sapiens_hsa051640.42177744
75Protein export_Homo sapiens_hsa030600.39563951
76Prostate cancer_Homo sapiens_hsa052150.39434116
77Colorectal cancer_Homo sapiens_hsa052100.38147916
78Primary immunodeficiency_Homo sapiens_hsa053400.37873060
79Graft-versus-host disease_Homo sapiens_hsa053320.36554596
80mTOR signaling pathway_Homo sapiens_hsa041500.35933178
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35885490
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.35557872
83Butanoate metabolism_Homo sapiens_hsa006500.35061658
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34833355
85Hepatitis B_Homo sapiens_hsa051610.34771573
86Metabolic pathways_Homo sapiens_hsa011000.33470885
87Linoleic acid metabolism_Homo sapiens_hsa005910.32628260
88Hippo signaling pathway_Homo sapiens_hsa043900.31151663
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29725481
90Alcoholism_Homo sapiens_hsa050340.29076354
91T cell receptor signaling pathway_Homo sapiens_hsa046600.28739360
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28215308
93Adherens junction_Homo sapiens_hsa045200.27867437
94Alzheimers disease_Homo sapiens_hsa050100.27116356
95N-Glycan biosynthesis_Homo sapiens_hsa005100.26448984
96Nitrogen metabolism_Homo sapiens_hsa009100.26034881
97Fatty acid metabolism_Homo sapiens_hsa012120.25036050
98HIF-1 signaling pathway_Homo sapiens_hsa040660.24834671
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23117321
100Wnt signaling pathway_Homo sapiens_hsa043100.23064057
101Basal cell carcinoma_Homo sapiens_hsa052170.22444165
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22346030
103Pathways in cancer_Homo sapiens_hsa052000.22154829
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21967332
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.21537162
106Apoptosis_Homo sapiens_hsa042100.21339776
107Huntingtons disease_Homo sapiens_hsa050160.21188719
108FoxO signaling pathway_Homo sapiens_hsa040680.20719835
109Allograft rejection_Homo sapiens_hsa053300.20601040
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20139967
111Inositol phosphate metabolism_Homo sapiens_hsa005620.19666475
112Pancreatic cancer_Homo sapiens_hsa052120.18955255
113Vitamin digestion and absorption_Homo sapiens_hsa049770.18947035
114Glutathione metabolism_Homo sapiens_hsa004800.18435310
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17695307
116Type I diabetes mellitus_Homo sapiens_hsa049400.16575782
117B cell receptor signaling pathway_Homo sapiens_hsa046620.16371996
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.16243159
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16155706
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15995004
121Viral myocarditis_Homo sapiens_hsa054160.15543308
122Olfactory transduction_Homo sapiens_hsa047400.15163732
123Chronic myeloid leukemia_Homo sapiens_hsa052200.14865136
124Non-small cell lung cancer_Homo sapiens_hsa052230.14454740
125Hematopoietic cell lineage_Homo sapiens_hsa046400.14229248
126Caffeine metabolism_Homo sapiens_hsa002320.13683519
127Tryptophan metabolism_Homo sapiens_hsa003800.13654249
128Peroxisome_Homo sapiens_hsa041460.13536855
129Sulfur metabolism_Homo sapiens_hsa009200.13269312
130Notch signaling pathway_Homo sapiens_hsa043300.12830889
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12111241
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.11867300
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11801910
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11529656
135Carbon metabolism_Homo sapiens_hsa012000.11253200
136Shigellosis_Homo sapiens_hsa051310.10954429
137Ether lipid metabolism_Homo sapiens_hsa005650.10814745
138Hedgehog signaling pathway_Homo sapiens_hsa043400.10562688
139Acute myeloid leukemia_Homo sapiens_hsa052210.09549795
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07864538

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