NOL8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.97643487
2positive regulation of chemokine biosynthetic process (GO:0045080)5.08814253
3regulation of isotype switching to IgG isotypes (GO:0048302)5.07431490
4regulation of podosome assembly (GO:0071801)4.88556785
5RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.28317229
6histone H4-K12 acetylation (GO:0043983)4.21648308
7regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.21242432
8regulation of MHC class II biosynthetic process (GO:0045346)4.19896939
9piRNA metabolic process (GO:0034587)4.14408591
10regulation of chemokine biosynthetic process (GO:0045073)4.13642704
11negative regulation of acute inflammatory response (GO:0002674)3.96757595
12regulation of vitamin D biosynthetic process (GO:0060556)3.89296024
13indolalkylamine metabolic process (GO:0006586)3.83686516
14positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.83014580
15regulation of chronic inflammatory response (GO:0002676)3.75510212
16regulation of vitamin metabolic process (GO:0030656)3.74991022
17tryptophan metabolic process (GO:0006568)3.69576782
18T cell differentiation involved in immune response (GO:0002292)3.69140932
19alpha-beta T cell differentiation involved in immune response (GO:0002293)3.69140932
20alpha-beta T cell activation involved in immune response (GO:0002287)3.69140932
21protein neddylation (GO:0045116)3.65039540
22endoderm formation (GO:0001706)3.53662913
23indole-containing compound catabolic process (GO:0042436)3.50234808
24indolalkylamine catabolic process (GO:0046218)3.50234808
25tryptophan catabolic process (GO:0006569)3.50234808
26positive regulation of organelle assembly (GO:1902117)3.49298724
27L-fucose metabolic process (GO:0042354)3.46278170
28L-fucose catabolic process (GO:0042355)3.46278170
29fucose catabolic process (GO:0019317)3.46278170
30isoprenoid biosynthetic process (GO:0008299)3.41552035
31CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40527861
32kynurenine metabolic process (GO:0070189)3.36040326
33phosphorelay signal transduction system (GO:0000160)3.33848354
34regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.30408655
35behavioral response to ethanol (GO:0048149)3.24371527
36negative regulation of organelle assembly (GO:1902116)3.16270029
37regulation of triglyceride catabolic process (GO:0010896)3.15075295
38regulation of B cell receptor signaling pathway (GO:0050855)3.13216559
39sphingomyelin metabolic process (GO:0006684)3.04557437
40protein complex biogenesis (GO:0070271)3.04549509
41indole-containing compound metabolic process (GO:0042430)3.03020877
42positive regulation of defense response to virus by host (GO:0002230)2.99161095
43phenylpropanoid metabolic process (GO:0009698)2.96597149
44negative regulation of T-helper cell differentiation (GO:0045623)2.95589410
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95589410
46regulation of interleukin-8 secretion (GO:2000482)2.91583038
47adenosine metabolic process (GO:0046085)2.90280259
48neuronal action potential (GO:0019228)2.89750839
49T-helper cell differentiation (GO:0042093)2.86114686
50CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86114686
51DNA deamination (GO:0045006)2.84333628
52retinal cone cell development (GO:0046549)2.82808425
53gamma-aminobutyric acid transport (GO:0015812)2.82057507
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81248345
55response to interferon-beta (GO:0035456)2.80107558
56ubiquinone biosynthetic process (GO:0006744)2.79546265
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78898935
58cell wall macromolecule metabolic process (GO:0044036)2.77807318
59regulation of cellular amino acid metabolic process (GO:0006521)2.76026680
60mitochondrial respiratory chain complex assembly (GO:0033108)2.74465497
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72277999
62detection of light stimulus involved in sensory perception (GO:0050962)2.71364093
63detection of light stimulus involved in visual perception (GO:0050908)2.71364093
64negative regulation of alpha-beta T cell differentiation (GO:0046639)2.70394855
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69784715
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.69784715
67NADH dehydrogenase complex assembly (GO:0010257)2.69784715
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68923695
69parturition (GO:0007567)2.67249097
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66422182
71ubiquinone metabolic process (GO:0006743)2.66156671
72cytokine production involved in immune response (GO:0002367)2.66149922
73water-soluble vitamin biosynthetic process (GO:0042364)2.64131265
74synaptic transmission, cholinergic (GO:0007271)2.62428457
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61236363
76flavonoid metabolic process (GO:0009812)2.60932625
77rRNA catabolic process (GO:0016075)2.60016212
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57779909
79metallo-sulfur cluster assembly (GO:0031163)2.56733909
80iron-sulfur cluster assembly (GO:0016226)2.56733909
81amine catabolic process (GO:0009310)2.56242327
82cellular biogenic amine catabolic process (GO:0042402)2.56242327
83pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.55280748
84UMP biosynthetic process (GO:0006222)2.55280748
85pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.55280748
86UMP metabolic process (GO:0046049)2.55280748
87magnesium ion transport (GO:0015693)2.55012696
88negative regulation of T cell differentiation in thymus (GO:0033085)2.54381382
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54169485
90negative regulation of calcium ion transport into cytosol (GO:0010523)2.54166185
91defense response to protozoan (GO:0042832)2.54159726
92primary amino compound metabolic process (GO:1901160)2.53405097
93histone H2A acetylation (GO:0043968)2.52334382
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51165342
95nucleotide salvage (GO:0043173)2.51165015
96cellular response to interferon-beta (GO:0035458)2.51164012
97sulfation (GO:0051923)2.50574864
98positive regulation of immunoglobulin production (GO:0002639)2.49330633
99alanine transport (GO:0032328)2.49300567
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.45906370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59002538
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13288718
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97235068
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.89182475
5VDR_22108803_ChIP-Seq_LS180_Human2.64649652
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54559668
7GBX2_23144817_ChIP-Seq_PC3_Human2.43368120
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.41101734
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25544804
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22618079
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19769461
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19375187
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.19153699
14ZNF274_21170338_ChIP-Seq_K562_Hela2.13005924
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07941818
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99139185
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92512958
18ER_23166858_ChIP-Seq_MCF-7_Human1.89903431
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79880337
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78902128
21EWS_26573619_Chip-Seq_HEK293_Human1.76149435
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75510317
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72320108
24FOXA1_25329375_ChIP-Seq_VCAP_Human1.72036676
25FOXA1_27270436_Chip-Seq_PROSTATE_Human1.72036676
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.69337751
27TP53_22573176_ChIP-Seq_HFKS_Human1.63069767
28IRF1_19129219_ChIP-ChIP_H3396_Human1.61349989
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60851832
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.59224408
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58513110
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.54578486
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52995259
34TAF15_26573619_Chip-Seq_HEK293_Human1.50255504
35REST_21632747_ChIP-Seq_MESCs_Mouse1.48846867
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46585876
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45288413
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45161589
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.41826415
40P300_19829295_ChIP-Seq_ESCs_Human1.41101704
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.40104169
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39456207
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36229244
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.30792717
45NCOR_22424771_ChIP-Seq_293T_Human1.29684176
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28789238
47SOX2_19829295_ChIP-Seq_ESCs_Human1.27943390
48NANOG_19829295_ChIP-Seq_ESCs_Human1.27943390
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26521926
50CBP_20019798_ChIP-Seq_JUKART_Human1.26521926
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26082817
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25139269
53RNF2_27304074_Chip-Seq_NSC_Mouse1.24975877
54AR_25329375_ChIP-Seq_VCAP_Human1.21118865
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19664271
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19664271
57MYC_18940864_ChIP-ChIP_HL60_Human1.19085681
58BCAT_22108803_ChIP-Seq_LS180_Human1.18595947
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.16534566
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15642135
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.15290023
62NANOG_20526341_ChIP-Seq_ESCs_Human1.15158611
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.14579551
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14480086
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14094113
66ERG_20517297_ChIP-Seq_VCAP_Human1.13875854
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12886611
68VDR_23849224_ChIP-Seq_CD4+_Human1.12718003
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12264169
70TAF2_19829295_ChIP-Seq_ESCs_Human1.12251192
71AR_21572438_ChIP-Seq_LNCaP_Human1.11152885
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09306883
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.08616202
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07494419
75OCT4_20526341_ChIP-Seq_ESCs_Human1.06149859
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05706527
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05560406
78FUS_26573619_Chip-Seq_HEK293_Human1.05319397
79FOXP3_21729870_ChIP-Seq_TREG_Human1.04653598
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03793419
81RUNX2_22187159_ChIP-Seq_PCA_Human1.02455765
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01828498
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01786461
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.01409996
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.01324338
86TCF4_22108803_ChIP-Seq_LS180_Human1.01259970
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.00699754
88P53_21459846_ChIP-Seq_SAOS-2_Human1.00679357
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00647455
90AR_20517297_ChIP-Seq_VCAP_Human1.00286764
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.00213782
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99988237
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99393431
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98374163
95RBPJ_21746931_ChIP-Seq_IB4_Human0.97379993
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96981490
97STAT3_23295773_ChIP-Seq_U87_Human0.96972942
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96949412
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96476511
100IGF1R_20145208_ChIP-Seq_DFB_Human0.96146956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.96403722
2MP0001873_stomach_inflammation4.78147390
3MP0001348_abnormal_lacrimal_gland3.22865199
4MP0005451_abnormal_body_composition3.10613445
5MP0001835_abnormal_antigen_presentation3.06630505
6MP0005646_abnormal_pituitary_gland3.02336475
7MP0008872_abnormal_physiological_respon2.72627592
8MP0005671_abnormal_response_to2.58242153
9MP0006292_abnormal_olfactory_placode2.32966657
10MP0001485_abnormal_pinna_reflex2.28021234
11MP0005551_abnormal_eye_electrophysiolog2.26961410
12MP0005645_abnormal_hypothalamus_physiol2.24905277
13MP0008875_abnormal_xenobiotic_pharmacok2.20901686
14MP0008877_abnormal_DNA_methylation2.10335653
15MP0004142_abnormal_muscle_tone2.09868825
16MP0009046_muscle_twitch2.00116525
17MP0006082_CNS_inflammation1.94734035
18MP0004742_abnormal_vestibular_system1.83874007
19MP0001440_abnormal_grooming_behavior1.83788225
20MP0002876_abnormal_thyroid_physiology1.83602272
21MP0004145_abnormal_muscle_electrophysio1.82477461
22MP0002272_abnormal_nervous_system1.80957562
23MP0009745_abnormal_behavioral_response1.72318624
24MP0002837_dystrophic_cardiac_calcinosis1.67101858
25MP0006276_abnormal_autonomic_nervous1.62622763
26MP0002282_abnormal_trachea_morphology1.60619579
27MP0002148_abnormal_hypersensitivity_rea1.53844879
28MP0002102_abnormal_ear_morphology1.53822699
29MP0001968_abnormal_touch/_nociception1.45539178
30MP0003283_abnormal_digestive_organ1.44961815
31MP0009764_decreased_sensitivity_to1.43708078
32MP0001905_abnormal_dopamine_level1.42902531
33MP0001663_abnormal_digestive_system1.42534317
34MP0001486_abnormal_startle_reflex1.41609945
35MP0001800_abnormal_humoral_immune1.38005471
36MP0003646_muscle_fatigue1.33836379
37MP0004782_abnormal_surfactant_physiolog1.33638525
38MP0003195_calcinosis1.32466449
39MP0003787_abnormal_imprinting1.28804891
40MP0002064_seizures1.27685222
41MP0002751_abnormal_autonomic_nervous1.26600266
42MP0001879_abnormal_lymphatic_vessel1.25589985
43MP0001986_abnormal_taste_sensitivity1.24353311
44MP0001188_hyperpigmentation1.23297616
45MP0009785_altered_susceptibility_to1.16769334
46MP0003950_abnormal_plasma_membrane1.14865477
47MP0009333_abnormal_splenocyte_physiolog1.12865647
48MP0002733_abnormal_thermal_nociception1.12552092
49MP0002736_abnormal_nociception_after1.11259069
50MP0005423_abnormal_somatic_nervous1.10018642
51MP0001970_abnormal_pain_threshold1.07134851
52MP0005000_abnormal_immune_tolerance1.05426257
53MP0003786_premature_aging1.04168783
54MP0003252_abnormal_bile_duct1.02894252
55MP0001542_abnormal_bone_strength1.02794850
56MP0002693_abnormal_pancreas_physiology1.02547067
57MP0001501_abnormal_sleep_pattern1.02225937
58MP0005253_abnormal_eye_physiology1.01807304
59MP0002277_abnormal_respiratory_mucosa1.01193866
60MP0001881_abnormal_mammary_gland1.00160075
61MP0003635_abnormal_synaptic_transmissio0.97243946
62MP0010386_abnormal_urinary_bladder0.97146532
63MP0003806_abnormal_nucleotide_metabolis0.95937819
64MP0009697_abnormal_copulation0.94936868
65MP0002572_abnormal_emotion/affect_behav0.91066651
66MP0006072_abnormal_retinal_apoptosis0.90279431
67MP0008775_abnormal_heart_ventricle0.89191435
68MP0002138_abnormal_hepatobiliary_system0.88653937
69MP0003880_abnormal_central_pattern0.86684175
70MP0002822_catalepsy0.86538471
71MP0005381_digestive/alimentary_phenotyp0.85460483
72MP0002067_abnormal_sensory_capabilities0.84946518
73MP0002160_abnormal_reproductive_system0.84121378
74MP0005085_abnormal_gallbladder_physiolo0.84029394
75MP0005410_abnormal_fertilization0.83897999
76MP0000470_abnormal_stomach_morphology0.82362828
77MP0009765_abnormal_xenobiotic_induced0.82213180
78MP0000049_abnormal_middle_ear0.81898305
79MP0002184_abnormal_innervation0.81180554
80MP0003633_abnormal_nervous_system0.80100406
81MP0005387_immune_system_phenotype0.79989680
82MP0001790_abnormal_immune_system0.79989680
83MP0008789_abnormal_olfactory_epithelium0.79887534
84MP0001324_abnormal_eye_pigmentation0.79626333
85MP0000427_abnormal_hair_cycle0.78898367
86MP0003890_abnormal_embryonic-extraembry0.78695789
87MP0002452_abnormal_antigen_presenting0.78460778
88MP0003136_yellow_coat_color0.77081401
89MP0000639_abnormal_adrenal_gland0.75984030
90MP0008004_abnormal_stomach_pH0.75483830
91MP0005319_abnormal_enzyme/_coenzyme0.74507273
92MP0000685_abnormal_immune_system0.73848333
93MP0000538_abnormal_urinary_bladder0.73579126
94MP0002229_neurodegeneration0.71930180
95MP0003186_abnormal_redox_activity0.69223578
96MP0000230_abnormal_systemic_arterial0.68085107
97MP0002735_abnormal_chemical_nociception0.68084187
98MP0001666_abnormal_nutrient_absorption0.67950310
99MP0003693_abnormal_embryo_hatching0.67841498
100MP0002063_abnormal_learning/memory/cond0.66180546

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.34649074
2Aplastic anemia (HP:0001915)4.20583813
3Decreased central vision (HP:0007663)3.93501593
4Molar tooth sign on MRI (HP:0002419)3.73508676
5Abnormality of midbrain morphology (HP:0002418)3.73508676
6Progressive cerebellar ataxia (HP:0002073)3.56291342
7Medial flaring of the eyebrow (HP:0010747)3.44957647
8Type II lissencephaly (HP:0007260)3.38754190
9Pancreatic cysts (HP:0001737)3.33316331
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.28902898
11Retinal dysplasia (HP:0007973)3.25499294
12Pancreatic fibrosis (HP:0100732)3.15702799
13Nephrogenic diabetes insipidus (HP:0009806)3.03974338
14Methylmalonic aciduria (HP:0012120)2.95470892
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95456357
16Acute necrotizing encephalopathy (HP:0006965)2.94506472
17B lymphocytopenia (HP:0010976)2.93460496
18Congenital stationary night blindness (HP:0007642)2.90920729
19Abnormal mitochondria in muscle tissue (HP:0008316)2.89572232
20Abnormality of B cell number (HP:0010975)2.83138992
21Gaze-evoked nystagmus (HP:0000640)2.78578532
22Abolished electroretinogram (ERG) (HP:0000550)2.76595526
23Abnormal rod and cone electroretinograms (HP:0008323)2.73124376
24Abnormality of alanine metabolism (HP:0010916)2.70011102
25Hyperalaninemia (HP:0003348)2.70011102
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70011102
27Gait imbalance (HP:0002141)2.68255788
28Congenital primary aphakia (HP:0007707)2.65944345
29Peritonitis (HP:0002586)2.65349748
30Optic disc pallor (HP:0000543)2.63256575
31Methylmalonic acidemia (HP:0002912)2.62863213
32Hypoproteinemia (HP:0003075)2.62072104
33Progressive macrocephaly (HP:0004481)2.57167894
34Renal cortical cysts (HP:0000803)2.51307725
35Increased corneal curvature (HP:0100692)2.51107754
36Keratoconus (HP:0000563)2.51107754
37Chronic bronchitis (HP:0004469)2.49017287
38Metaphyseal dysplasia (HP:0100255)2.41000116
39Mitochondrial inheritance (HP:0001427)2.37467276
40Diplopia (HP:0000651)2.34280942
41Abnormality of binocular vision (HP:0011514)2.34280942
42Neuroendocrine neoplasm (HP:0100634)2.33046656
43Alveolar cell carcinoma (HP:0006519)2.30028315
44Fibular aplasia (HP:0002990)2.28617543
45Congenital, generalized hypertrichosis (HP:0004540)2.28087886
46Acute encephalopathy (HP:0006846)2.28063738
47Hepatic necrosis (HP:0002605)2.26008875
48True hermaphroditism (HP:0010459)2.22884027
49Increased CSF lactate (HP:0002490)2.19792184
50Severe combined immunodeficiency (HP:0004430)2.19664949
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19533025
52Dicarboxylic aciduria (HP:0003215)2.19533025
53Midline defect of the nose (HP:0004122)2.17752146
54Autoamputation (HP:0001218)2.16131795
55Increased number of teeth (HP:0011069)2.12733686
56Attenuation of retinal blood vessels (HP:0007843)2.10311937
57Increased serum lactate (HP:0002151)2.10138606
58Pendular nystagmus (HP:0012043)2.09570917
59Astrocytoma (HP:0009592)2.08773086
60Abnormality of the astrocytes (HP:0100707)2.08773086
61Abnormality of the renal cortex (HP:0011035)2.06324388
62Mesangial abnormality (HP:0001966)2.02331883
63Nephronophthisis (HP:0000090)2.01671123
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00102521
65Cystic liver disease (HP:0006706)2.00072050
66Lissencephaly (HP:0001339)1.98791844
67Stomatitis (HP:0010280)1.98510032
68Meningioma (HP:0002858)1.98458967
69Hepatocellular necrosis (HP:0001404)1.97880578
70Genital tract atresia (HP:0001827)1.96714768
71IgG deficiency (HP:0004315)1.96624626
72Cerebral edema (HP:0002181)1.96334634
73Cerebellar dysplasia (HP:0007033)1.93289305
74Generalized aminoaciduria (HP:0002909)1.92373164
75Inability to walk (HP:0002540)1.90121299
76Microretrognathia (HP:0000308)1.89620601
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.88501219
78Pheochromocytoma (HP:0002666)1.86466868
79Specific learning disability (HP:0001328)1.84139176
80Hamartoma of the eye (HP:0010568)1.84099984
81Neoplasm of the tracheobronchial system (HP:0100552)1.83176787
82Macular degeneration (HP:0000608)1.82281478
83Thyroiditis (HP:0100646)1.82102182
84Slender build (HP:0001533)1.81994790
85Curly hair (HP:0002212)1.81290013
86Porencephaly (HP:0002132)1.80863051
87Vaginal atresia (HP:0000148)1.79711076
88Intellectual disability, profound (HP:0002187)1.79581611
89Colon cancer (HP:0003003)1.79551897
90Chronic hepatic failure (HP:0100626)1.77585591
91Progressive inability to walk (HP:0002505)1.77428576
92Pancytopenia (HP:0001876)1.76955945
93Abnormality of the prostate (HP:0008775)1.76563721
94Large for gestational age (HP:0001520)1.75967236
95Abnormal respiratory motile cilium physiology (HP:0012261)1.75464952
96Tubular atrophy (HP:0000092)1.73078291
97Anencephaly (HP:0002323)1.72772521
98Delayed myelination (HP:0012448)1.70248831
99Flat capital femoral epiphysis (HP:0003370)1.68738539
100Lethargy (HP:0001254)1.68323711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.95706904
2EIF2AK14.60785248
3STK163.64538320
4CDK192.86439916
5FRK2.78235000
6BMPR1B2.61354840
7NUAK12.60590008
8BMPR22.60329266
9PBK2.45138924
10EIF2AK32.40684924
11NME12.30392866
12BCKDK1.91772892
13TEC1.91641844
14MAP3K121.86477162
15CSF1R1.71773872
16PIK3CG1.69493683
17STK241.66497214
18ADRBK21.63728116
19ITK1.63215801
20WNK31.58764417
21TLK11.52562079
22GRK11.51911544
23TXK1.45800315
24STK31.37570846
25CDC71.34006412
26PINK11.28688965
27ZAK1.24334735
28WNK41.19104085
29IKBKB1.18973268
30EPHB21.10028083
31TRPM71.08495493
32TSSK61.01593828
33DMPK1.00253460
34KIT1.00209974
35ILK0.94497238
36BRD40.92412377
37PIK3CA0.89029845
38CDK80.87819586
39MINK10.85550280
40TIE10.85083752
41MKNK10.85043325
42ADRBK10.83813689
43MAP3K140.82895451
44KDR0.79627424
45FLT30.79097799
46ACVR1B0.78747296
47OXSR10.76796755
48MST40.73687304
49INSRR0.71514489
50CSNK1G20.70640055
51WNK10.69846680
52PRKCQ0.69721401
53TNK20.67915475
54CHUK0.67547030
55RPS6KA50.65133966
56MAPK130.65101549
57BTK0.64262301
58MAP2K40.62550548
59IRAK10.61104754
60MAP4K10.60274810
61PRKCH0.58930794
62MAP4K20.56172396
63PKN10.55961983
64MAPKAPK50.55769321
65PLK10.55687670
66PRKCG0.55594093
67SYK0.55316584
68DAPK20.54806354
69PRKACA0.54800966
70MAP3K90.52128505
71DAPK10.51634781
72BUB10.49869774
73MYLK0.49278380
74CDK30.48095952
75PRKCA0.45121156
76PNCK0.44051116
77MAP2K60.42789073
78PDK20.42664796
79CSNK1D0.41843669
80EIF2AK20.41820103
81STK40.41057853
82ALK0.39197228
83PRKG10.39138093
84ERBB30.38313273
85CAMK2D0.38005392
86LCK0.37621015
87GRK70.36952811
88ABL10.36767349
89CAMK2A0.36410252
90TNIK0.34759179
91MATK0.34531669
92PTK2B0.34350461
93OBSCN0.33570484
94PHKG10.33559477
95PHKG20.33559477
96PRKCE0.33460558
97PRKACG0.33221334
98IGF1R0.31797942
99VRK10.31320891
100MAP3K70.31186116

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.58299285
2Allograft rejection_Homo sapiens_hsa053303.58638106
3Proteasome_Homo sapiens_hsa030503.53368572
4Autoimmune thyroid disease_Homo sapiens_hsa053203.07687908
5Protein export_Homo sapiens_hsa030602.92191495
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.80521740
7Oxidative phosphorylation_Homo sapiens_hsa001902.51030874
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24727699
9Nicotine addiction_Homo sapiens_hsa050332.18622041
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15042662
11Graft-versus-host disease_Homo sapiens_hsa053322.09397288
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07396391
13Parkinsons disease_Homo sapiens_hsa050121.96330249
14RNA polymerase_Homo sapiens_hsa030201.93996826
15Linoleic acid metabolism_Homo sapiens_hsa005911.86890835
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69338521
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67455797
18Nitrogen metabolism_Homo sapiens_hsa009101.61962563
19Rheumatoid arthritis_Homo sapiens_hsa053231.54207322
20Primary immunodeficiency_Homo sapiens_hsa053401.52278438
21Mismatch repair_Homo sapiens_hsa034301.49658025
22Type I diabetes mellitus_Homo sapiens_hsa049401.47527712
23Phototransduction_Homo sapiens_hsa047441.46199189
24Cardiac muscle contraction_Homo sapiens_hsa042601.44311153
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41694329
26Hematopoietic cell lineage_Homo sapiens_hsa046401.35133981
27T cell receptor signaling pathway_Homo sapiens_hsa046601.33737962
28Olfactory transduction_Homo sapiens_hsa047401.31992687
29Alzheimers disease_Homo sapiens_hsa050101.29733392
30Ribosome_Homo sapiens_hsa030101.28156981
31Arachidonic acid metabolism_Homo sapiens_hsa005901.27097904
32Antigen processing and presentation_Homo sapiens_hsa046121.24377525
33Pancreatic secretion_Homo sapiens_hsa049721.22577528
34Tryptophan metabolism_Homo sapiens_hsa003801.21367546
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18399363
36RNA degradation_Homo sapiens_hsa030181.16290168
37Ether lipid metabolism_Homo sapiens_hsa005651.15626997
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.15344339
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10580345
40Huntingtons disease_Homo sapiens_hsa050161.10335820
41Fat digestion and absorption_Homo sapiens_hsa049751.10031780
42DNA replication_Homo sapiens_hsa030301.06286239
43Long-term depression_Homo sapiens_hsa047301.04662620
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04011283
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03756362
46Pyrimidine metabolism_Homo sapiens_hsa002401.02692949
47Homologous recombination_Homo sapiens_hsa034401.02110587
48Circadian entrainment_Homo sapiens_hsa047130.95418552
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95185852
50Selenocompound metabolism_Homo sapiens_hsa004500.89348453
51Glutamatergic synapse_Homo sapiens_hsa047240.88846650
52Chemical carcinogenesis_Homo sapiens_hsa052040.86081054
53Sphingolipid metabolism_Homo sapiens_hsa006000.86054606
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.85747281
55Caffeine metabolism_Homo sapiens_hsa002320.83358073
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82221019
57Dorso-ventral axis formation_Homo sapiens_hsa043200.81972944
58Serotonergic synapse_Homo sapiens_hsa047260.77346294
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76177567
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75332455
61Morphine addiction_Homo sapiens_hsa050320.73611539
62Sulfur metabolism_Homo sapiens_hsa009200.72880367
63Taste transduction_Homo sapiens_hsa047420.70579324
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70395264
65GABAergic synapse_Homo sapiens_hsa047270.66001251
66Nucleotide excision repair_Homo sapiens_hsa034200.65178802
67Purine metabolism_Homo sapiens_hsa002300.65035505
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62436194
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61462792
70Regulation of autophagy_Homo sapiens_hsa041400.60242556
71African trypanosomiasis_Homo sapiens_hsa051430.59267979
72Cholinergic synapse_Homo sapiens_hsa047250.55066160
73Collecting duct acid secretion_Homo sapiens_hsa049660.55061372
74Fanconi anemia pathway_Homo sapiens_hsa034600.53505170
75Salivary secretion_Homo sapiens_hsa049700.47802669
76Systemic lupus erythematosus_Homo sapiens_hsa053220.43866603
77Peroxisome_Homo sapiens_hsa041460.43030316
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42912801
79Metabolic pathways_Homo sapiens_hsa011000.41277636
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41168943
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40068477
82Staphylococcus aureus infection_Homo sapiens_hsa051500.39242370
83Retinol metabolism_Homo sapiens_hsa008300.38523688
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37878863
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.36691447
86One carbon pool by folate_Homo sapiens_hsa006700.35134702
87Ovarian steroidogenesis_Homo sapiens_hsa049130.34365776
88Spliceosome_Homo sapiens_hsa030400.33558666
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32807379
90Leishmaniasis_Homo sapiens_hsa051400.32299811
91Measles_Homo sapiens_hsa051620.30636240
92Glycerolipid metabolism_Homo sapiens_hsa005610.30250013
93Sulfur relay system_Homo sapiens_hsa041220.29973196
94Calcium signaling pathway_Homo sapiens_hsa040200.29375286
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29272370
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28887175
97RNA transport_Homo sapiens_hsa030130.28879940
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27303345
99Dopaminergic synapse_Homo sapiens_hsa047280.27266639
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27178482

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