NOLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.06021764
2purine nucleobase biosynthetic process (GO:0009113)4.81157912
3protein localization to kinetochore (GO:0034501)4.77542492
4mitotic metaphase plate congression (GO:0007080)4.65726970
5establishment of integrated proviral latency (GO:0075713)4.64801382
6DNA unwinding involved in DNA replication (GO:0006268)4.62404021
7ribosome assembly (GO:0042255)4.55251583
8mitotic sister chromatid cohesion (GO:0007064)4.53735224
9nuclear pore organization (GO:0006999)4.52796601
10DNA replication initiation (GO:0006270)4.52022191
11formation of translation preinitiation complex (GO:0001731)4.50550223
12maturation of SSU-rRNA (GO:0030490)4.50106272
13ribosome biogenesis (GO:0042254)4.46398659
14regulation of translational fidelity (GO:0006450)4.43363131
15IMP biosynthetic process (GO:0006188)4.40352600
16DNA strand elongation involved in DNA replication (GO:0006271)4.36970948
17mitotic nuclear envelope disassembly (GO:0007077)4.33011672
18DNA replication checkpoint (GO:0000076)4.28321522
19nuclear pore complex assembly (GO:0051292)4.27295089
20folic acid-containing compound biosynthetic process (GO:0009396)4.24061065
21DNA strand elongation (GO:0022616)4.15864468
22nuclear envelope disassembly (GO:0051081)4.02376158
23membrane disassembly (GO:0030397)4.02376158
24DNA replication-dependent nucleosome assembly (GO:0006335)3.99974319
25DNA replication-dependent nucleosome organization (GO:0034723)3.99974319
26ribonucleoprotein complex biogenesis (GO:0022613)3.99707218
27protein localization to chromosome, centromeric region (GO:0071459)3.98182000
28metaphase plate congression (GO:0051310)3.92636294
29telomere maintenance via semi-conservative replication (GO:0032201)3.86640228
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80199472
31IMP metabolic process (GO:0046040)3.79295490
32ribosomal large subunit biogenesis (GO:0042273)3.76879227
33regulation of spindle organization (GO:0090224)3.76820573
34regulation of centriole replication (GO:0046599)3.73666647
35double-strand break repair via nonhomologous end joining (GO:0006303)3.68412006
36non-recombinational repair (GO:0000726)3.68412006
37mitotic sister chromatid segregation (GO:0000070)3.66638094
38negative regulation of mRNA processing (GO:0050686)3.64993482
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60668267
40* rRNA processing (GO:0006364)3.59810348
41protein complex localization (GO:0031503)3.57164818
42spliceosomal snRNP assembly (GO:0000387)3.55266436
43chromosome condensation (GO:0030261)3.52243239
44negative regulation of mRNA metabolic process (GO:1903312)3.52214521
45telomere maintenance via recombination (GO:0000722)3.48949951
46* rRNA metabolic process (GO:0016072)3.48598470
47tRNA aminoacylation for protein translation (GO:0006418)3.46464817
48positive regulation of chromosome segregation (GO:0051984)3.45998324
49folic acid metabolic process (GO:0046655)3.45481222
50establishment of viral latency (GO:0019043)3.45309529
51DNA duplex unwinding (GO:0032508)3.44782103
52DNA geometric change (GO:0032392)3.43448381
53mitotic recombination (GO:0006312)3.43054724
54chromatin remodeling at centromere (GO:0031055)3.42905673
55DNA topological change (GO:0006265)3.41902654
56CENP-A containing nucleosome assembly (GO:0034080)3.41065903
57tRNA aminoacylation (GO:0043039)3.40892977
58amino acid activation (GO:0043038)3.40892977
59ribosomal small subunit assembly (GO:0000028)3.38559092
60DNA replication-independent nucleosome organization (GO:0034724)3.38159029
61DNA replication-independent nucleosome assembly (GO:0006336)3.38159029
62translational initiation (GO:0006413)3.35650226
63sister chromatid segregation (GO:0000819)3.35187874
64establishment of chromosome localization (GO:0051303)3.33968595
65pore complex assembly (GO:0046931)3.32604857
66DNA conformation change (GO:0071103)3.32068767
67regulation of translational termination (GO:0006449)3.31082209
68kinetochore organization (GO:0051383)3.29390167
69mitotic chromosome condensation (GO:0007076)3.28733096
70telomere maintenance via telomere lengthening (GO:0010833)3.27676448
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.26987749
72ribosomal small subunit biogenesis (GO:0042274)3.26304397
73regulation of mitotic spindle organization (GO:0060236)3.25826821
74DNA packaging (GO:0006323)3.24689097
75maturation of 5.8S rRNA (GO:0000460)3.23475405
76translational termination (GO:0006415)3.21883298
77cellular protein complex localization (GO:0034629)3.20800039
78viral transcription (GO:0019083)3.20503375
79nuclear envelope organization (GO:0006998)3.20286269
80spliceosomal tri-snRNP complex assembly (GO:0000244)3.20192604
81transcription from mitochondrial promoter (GO:0006390)3.14547890
82heterochromatin organization (GO:0070828)3.14399986
83rRNA methylation (GO:0031167)3.13794430
84attachment of spindle microtubules to kinetochore (GO:0008608)3.13689612
85rRNA modification (GO:0000154)3.11569535
86RNA splicing, via transesterification reactions (GO:0000375)3.09813800
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.09283954
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09283954
89spindle checkpoint (GO:0031577)3.08956836
90pseudouridine synthesis (GO:0001522)3.08546624
91mRNA splicing, via spliceosome (GO:0000398)3.08246250
92RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08246250
93DNA ligation (GO:0006266)3.07578287
94regulation of posttranscriptional gene silencing (GO:0060147)3.07132480
95regulation of gene silencing by miRNA (GO:0060964)3.07132480
96regulation of gene silencing by RNA (GO:0060966)3.07132480
97negative regulation of chromosome segregation (GO:0051985)3.07125350
98regulation of centrosome cycle (GO:0046605)3.06212550
99regulation of chromosome segregation (GO:0051983)3.05230744
100termination of RNA polymerase II transcription (GO:0006369)3.04397358
101viral mRNA export from host cell nucleus (GO:0046784)3.03876065
102chromatin assembly or disassembly (GO:0006333)3.03726917
103regulation of translational elongation (GO:0006448)3.03610951
104regulation of RNA export from nucleus (GO:0046831)3.03475486
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.03278779
106mitochondrial RNA metabolic process (GO:0000959)3.02940827
107histone exchange (GO:0043486)3.02901187
108DNA deamination (GO:0045006)3.02805444
109regulation of nuclear cell cycle DNA replication (GO:0033262)3.02091638
110kinetochore assembly (GO:0051382)3.01774479
111translational elongation (GO:0006414)3.01434101
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00239954
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00055789
114negative regulation of sister chromatid segregation (GO:0033046)3.00055789
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.00055789
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00055789
117mitotic spindle checkpoint (GO:0071174)2.99088885
118L-serine metabolic process (GO:0006563)2.98177522
119protein localization to chromosome (GO:0034502)2.96598356
120negative regulation of RNA splicing (GO:0033119)2.96585860
121spindle assembly checkpoint (GO:0071173)2.95961881
122mitotic spindle assembly checkpoint (GO:0007094)2.94952538
123peptidyl-arginine omega-N-methylation (GO:0035247)2.93976047
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.93780359
125termination of RNA polymerase I transcription (GO:0006363)2.93592168
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93067952
127spliceosomal complex assembly (GO:0000245)2.91348440
128pre-miRNA processing (GO:0031054)2.90973940
129ATP-dependent chromatin remodeling (GO:0043044)2.90215542
130mRNA transport (GO:0051028)2.89968257
131chromosome segregation (GO:0007059)2.88902163
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87816812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human8.52472937
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.50636257
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.23027176
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67330302
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63655450
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.33314993
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11612337
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93614997
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81599948
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.76609128
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.74944712
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70539935
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58853097
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56882987
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.47434306
16XRN2_22483619_ChIP-Seq_HELA_Human2.40578431
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37844335
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23629948
19* AR_21909140_ChIP-Seq_LNCAP_Human2.20143059
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.19649624
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16786434
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10579514
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07597933
24* VDR_23849224_ChIP-Seq_CD4+_Human2.06127817
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.02341427
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97270114
27MYC_22102868_ChIP-Seq_BL_Human1.95775392
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94697201
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93081133
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88516167
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87255642
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.87021810
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86143197
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85382337
35* TTF2_22483619_ChIP-Seq_HELA_Human1.81930908
36* GABP_19822575_ChIP-Seq_HepG2_Human1.81782525
37* DCP1A_22483619_ChIP-Seq_HELA_Human1.76343121
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71442627
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66776490
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64376800
41CIITA_25753668_ChIP-Seq_RAJI_Human1.60538340
42* KDM5A_27292631_Chip-Seq_BREAST_Human1.60523631
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56629412
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56219890
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52383498
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48538265
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47975761
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.45910253
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.43611921
50ELK1_19687146_ChIP-ChIP_HELA_Human1.43550486
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41533182
52* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41106670
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39291573
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36325351
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35644381
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34744433
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30479364
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29143053
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28133188
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25647235
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23489413
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23314209
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.22996267
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20300698
65* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19527436
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15828879
67TFEB_21752829_ChIP-Seq_HELA_Human1.14495132
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14432930
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13813729
70* CHD1_26751641_Chip-Seq_LNCaP_Human1.13463987
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13368652
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13368652
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13368652
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13062455
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11830078
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11485052
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10542616
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10003218
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08813023
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08035804
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06970405
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.04909440
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04008924
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00873628
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.00188750
86* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98960364
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98378556
88* SRF_21415370_ChIP-Seq_HL-1_Mouse0.97269518
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95118682
90* SOX17_20123909_ChIP-Seq_XEN_Mouse0.95057321
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95043443
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93103396
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92858870
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92766997
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92139076
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91675476
97* VDR_21846776_ChIP-Seq_THP-1_Human0.90311948
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88694215
99MYC_18940864_ChIP-ChIP_HL60_Human0.87747250
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86666968
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85963389
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85496611
103ZNF263_19887448_ChIP-Seq_K562_Human0.83331532
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83194863
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82269113
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.81717886
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81649964
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80924006
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80923318
110* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80679909
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77970685
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76233923
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73860677
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72847228
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71191868
116* NANOG_16153702_ChIP-ChIP_HESCs_Human0.68922093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69174176
2MP0003111_abnormal_nucleus_morphology4.88151425
3MP0004957_abnormal_blastocyst_morpholog4.70673961
4MP0010094_abnormal_chromosome_stability4.61435931
5MP0003077_abnormal_cell_cycle4.11040488
6MP0008057_abnormal_DNA_replication4.08709893
7MP0008058_abnormal_DNA_repair3.18355972
8MP0008007_abnormal_cellular_replicative2.82115987
9MP0001730_embryonic_growth_arrest2.81681932
10MP0003123_paternal_imprinting2.76435616
11MP0008932_abnormal_embryonic_tissue2.67665556
12MP0000350_abnormal_cell_proliferation2.52615100
13MP0010352_gastrointestinal_tract_polyps2.50485079
14MP0002396_abnormal_hematopoietic_system2.32461464
15MP0010307_abnormal_tumor_latency2.24964670
16MP0001672_abnormal_embryogenesis/_devel2.15685464
17MP0005380_embryogenesis_phenotype2.15685464
18MP0003786_premature_aging2.02570563
19MP0001697_abnormal_embryo_size1.99516135
20MP0003718_maternal_effect1.94313012
21MP0003984_embryonic_growth_retardation1.94125958
22MP0008877_abnormal_DNA_methylation1.90467956
23MP0002088_abnormal_embryonic_growth/wei1.90310042
24MP0009697_abnormal_copulation1.85971151
25MP0002080_prenatal_lethality1.85307787
26MP0002085_abnormal_embryonic_tissue1.82262278
27MP0002084_abnormal_developmental_patter1.78735929
28MP0010234_abnormal_vibrissa_follicle1.78547443
29MP0002877_abnormal_melanocyte_morpholog1.76571072
30MP0002086_abnormal_extraembryonic_tissu1.68680563
31MP0004197_abnormal_fetal_growth/weight/1.64466068
32MP0000490_abnormal_crypts_of1.56910460
33MP0005076_abnormal_cell_differentiation1.54275758
34MP0003890_abnormal_embryonic-extraembry1.51748163
35MP0004185_abnormal_adipocyte_glucose1.49833605
36MP0000313_abnormal_cell_death1.48630981
37MP0003567_abnormal_fetal_cardiomyocyte1.48252503
38MP0004808_abnormal_hematopoietic_stem1.41758513
39MP0003121_genomic_imprinting1.37492731
40MP0010030_abnormal_orbit_morphology1.36123354
41MP0006035_abnormal_mitochondrial_morpho1.35911909
42MP0002019_abnormal_tumor_incidence1.35535468
43MP0009333_abnormal_splenocyte_physiolog1.28566432
44MP0002009_preneoplasia1.27536507
45MP0002653_abnormal_ependyma_morphology1.24506873
46MP0001293_anophthalmia1.23922025
47MP0003119_abnormal_digestive_system1.20016877
48MP0002796_impaired_skin_barrier1.18832663
49MP0009672_abnormal_birth_weight1.16907113
50MP0001346_abnormal_lacrimal_gland1.16656541
51MP0000537_abnormal_urethra_morphology1.13919461
52MP0003705_abnormal_hypodermis_morpholog1.08695241
53MP0001545_abnormal_hematopoietic_system1.07979161
54MP0005397_hematopoietic_system_phenotyp1.07979161
55MP0002210_abnormal_sex_determination1.06462488
56MP0000703_abnormal_thymus_morphology1.04947350
57MP0003315_abnormal_perineum_morphology1.03932680
58MP0003941_abnormal_skin_development0.96506606
59MP0001145_abnormal_male_reproductive0.96282198
60MP0001661_extended_life_span0.95678725
61MP0003763_abnormal_thymus_physiology0.94608724
62MP0009053_abnormal_anal_canal0.93989667
63MP0009703_decreased_birth_body0.93906005
64MP0002111_abnormal_tail_morphology0.93751145
65MP0000579_abnormal_nail_morphology0.91198965
66MP0000428_abnormal_craniofacial_morphol0.90893791
67MP0003806_abnormal_nucleotide_metabolis0.89936311
68MP0001849_ear_inflammation0.89115525
69MP0003221_abnormal_cardiomyocyte_apopto0.88595317
70MP0005384_cellular_phenotype0.87512737
71MP0003937_abnormal_limbs/digits/tail_de0.86833795
72MP0005621_abnormal_cell_physiology0.86404163
73MP0000358_abnormal_cell_content/0.85163189
74MP0002722_abnormal_immune_system0.84555304
75MP0006036_abnormal_mitochondrial_physio0.82411618
76MP0005451_abnormal_body_composition0.82227947
77MP0002398_abnormal_bone_marrow0.80709742
78MP0003943_abnormal_hepatobiliary_system0.80611162
79MP0000653_abnormal_sex_gland0.80124731
80MP0004133_heterotaxia0.79488420
81MP0006292_abnormal_olfactory_placode0.79340034
82MP0000750_abnormal_muscle_regeneration0.77812041
83MP0004264_abnormal_extraembryonic_tissu0.77249997
84MP0005023_abnormal_wound_healing0.77018123
85MP0003566_abnormal_cell_adhesion0.76805639
86MP0001929_abnormal_gametogenesis0.76581486
87MP0009278_abnormal_bone_marrow0.76569321
88MP0002092_abnormal_eye_morphology0.75449486
89MP0000689_abnormal_spleen_morphology0.75422745
90MP0002160_abnormal_reproductive_system0.75094092
91MP0001881_abnormal_mammary_gland0.75013053
92MP0001348_abnormal_lacrimal_gland0.73769524
93MP0001915_intracranial_hemorrhage0.72679410
94MP0000678_abnormal_parathyroid_gland0.68984191
95MP0000858_altered_metastatic_potential0.68148948
96MP0000432_abnormal_head_morphology0.66510944
97MP0002161_abnormal_fertility/fecundity0.66446934
98MP0002006_tumorigenesis0.65641473
99MP0001286_abnormal_eye_development0.65490011
100MP0001216_abnormal_epidermal_layer0.65166045
101MP0003698_abnormal_male_reproductive0.65139766
102MP0008770_decreased_survivor_rate0.64325893
103MP0004782_abnormal_surfactant_physiolog0.63844578
104MP0000762_abnormal_tongue_morphology0.63828761
105MP0001119_abnormal_female_reproductive0.63256437
106MP0001188_hyperpigmentation0.63237244
107MP0002060_abnormal_skin_morphology0.62936574
108MP0000477_abnormal_intestine_morphology0.61878372
109MP0000733_abnormal_muscle_development0.61869620
110MP0002163_abnormal_gland_morphology0.61173799
111MP0005389_reproductive_system_phenotype0.61121101
112MP0002429_abnormal_blood_cell0.60209738
113MP0001727_abnormal_embryo_implantation0.59428840
114MP0005501_abnormal_skin_physiology0.58565424
115MP0000627_abnormal_mammary_gland0.58399570
116MP0002132_abnormal_respiratory_system0.57162913
117MP0003861_abnormal_nervous_system0.57115830
118MP0002269_muscular_atrophy0.56816565
119MP0003935_abnormal_craniofacial_develop0.55101812
120MP0003755_abnormal_palate_morphology0.54771988
121MP0002081_perinatal_lethality0.54756525
122MP0005410_abnormal_fertilization0.54260175
123MP0002925_abnormal_cardiovascular_devel0.53676897
124MP0003936_abnormal_reproductive_system0.53229779
125MP0003385_abnormal_body_wall0.53015850
126MP0002697_abnormal_eye_size0.51848223
127MP0003115_abnormal_respiratory_system0.51633635
128MP0004233_abnormal_muscle_weight0.51254721
129MP0003699_abnormal_female_reproductive0.50225939
130MP0002114_abnormal_axial_skeleton0.49145507

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.02697534
2Breast hypoplasia (HP:0003187)4.21659970
3Ependymoma (HP:0002888)3.88200299
4Chromsome breakage (HP:0040012)3.61355766
5Patellar aplasia (HP:0006443)3.58350755
6Selective tooth agenesis (HP:0001592)3.52108451
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49707021
8Abnormality of glycolysis (HP:0004366)3.49422834
9Reticulocytopenia (HP:0001896)3.45336881
10Aplasia/Hypoplasia of the patella (HP:0006498)3.43370700
11Medulloblastoma (HP:0002885)3.37367239
12Degeneration of anterior horn cells (HP:0002398)3.34710877
13Abnormality of the anterior horn cell (HP:0006802)3.34710877
14Impulsivity (HP:0100710)3.34449704
15Cerebral hypomyelination (HP:0006808)3.32381499
16Abnormality of the labia minora (HP:0012880)3.28344098
17Carpal bone hypoplasia (HP:0001498)3.24953736
18Rough bone trabeculation (HP:0100670)3.22331571
19Colon cancer (HP:0003003)3.16712179
20Abnormality of cells of the erythroid lineage (HP:0012130)3.13086747
21Microvesicular hepatic steatosis (HP:0001414)3.11942436
22Oral leukoplakia (HP:0002745)3.08090621
23Increased serum pyruvate (HP:0003542)3.07112365
24Nephroblastoma (Wilms tumor) (HP:0002667)3.00962632
25Meckel diverticulum (HP:0002245)2.95539301
26Abnormality of chromosome stability (HP:0003220)2.95416937
27Abnormal number of erythroid precursors (HP:0012131)2.92202234
28Progressive external ophthalmoplegia (HP:0000590)2.92148940
29Abnormality of the preputium (HP:0100587)2.89737937
30Absent radius (HP:0003974)2.86862378
31Abnormality of the ileum (HP:0001549)2.82896257
32Embryonal renal neoplasm (HP:0011794)2.79598521
33Multiple enchondromatosis (HP:0005701)2.72442621
34Trismus (HP:0000211)2.71682562
35Rhabdomyosarcoma (HP:0002859)2.70195921
36Abnormal number of incisors (HP:0011064)2.69956732
37Aplasia involving forearm bones (HP:0009822)2.66456868
38Absent forearm bone (HP:0003953)2.66456868
39Proximal placement of thumb (HP:0009623)2.63548130
40Absent thumb (HP:0009777)2.62551882
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.61549643
42Agnosia (HP:0010524)2.59857654
43Deviation of the thumb (HP:0009603)2.53790211
44Abnormality of the astrocytes (HP:0100707)2.52704873
45Astrocytoma (HP:0009592)2.52704873
46Myelodysplasia (HP:0002863)2.51159868
47Neoplasm of the pancreas (HP:0002894)2.47935396
48Macrocytic anemia (HP:0001972)2.46352507
49Basal cell carcinoma (HP:0002671)2.45841666
50Small intestinal stenosis (HP:0012848)2.42381985
51Duodenal stenosis (HP:0100867)2.42381985
52Glioma (HP:0009733)2.41484934
53Aplastic anemia (HP:0001915)2.40916071
54Squamous cell carcinoma (HP:0002860)2.38541115
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36827332
56Atresia of the external auditory canal (HP:0000413)2.35209282
57Premature ovarian failure (HP:0008209)2.35136190
58Premature graying of hair (HP:0002216)2.33193272
59Horseshoe kidney (HP:0000085)2.30384117
60Prominent nose (HP:0000448)2.28427882
61Supernumerary spleens (HP:0009799)2.26399722
62Abnormal trabecular bone morphology (HP:0100671)2.26016381
63Facial hemangioma (HP:0000329)2.20892504
64Glossoptosis (HP:0000162)2.19636051
65Microretrognathia (HP:0000308)2.19550307
66Deep philtrum (HP:0002002)2.17502844
67Aplasia/hypoplasia of the humerus (HP:0006507)2.16631168
68Tracheoesophageal fistula (HP:0002575)2.16510956
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16270281
70Increased nuchal translucency (HP:0010880)2.15881223
71Bone marrow hypocellularity (HP:0005528)2.14710971
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.14506381
73Cortical dysplasia (HP:0002539)2.14351020
74Secondary amenorrhea (HP:0000869)2.13986196
75Septate vagina (HP:0001153)2.13035613
76Cafe-au-lait spot (HP:0000957)2.12812084
77Ectopic kidney (HP:0000086)2.10931536
78Neoplasm of striated muscle (HP:0009728)2.10913967
79Facial cleft (HP:0002006)2.10329871
80Sloping forehead (HP:0000340)2.09677779
81Sparse lateral eyebrow (HP:0005338)2.08983198
82Pallor (HP:0000980)2.08762035
83Abnormality of cochlea (HP:0000375)2.07774995
84Urethral obstruction (HP:0000796)2.05199600
85Neoplasm of the oral cavity (HP:0100649)2.04641181
86Pelvic girdle muscle weakness (HP:0003749)2.03974545
87Sensory axonal neuropathy (HP:0003390)2.03278278
88Entropion (HP:0000621)2.03112595
89Short thumb (HP:0009778)2.02411143
90Abnormality of the duodenum (HP:0002246)2.01742975
91Insomnia (HP:0100785)2.00278951
92Cellular immunodeficiency (HP:0005374)1.99422239
93Acute myeloid leukemia (HP:0004808)1.99408387
94Ragged-red muscle fibers (HP:0003200)1.98374128
95Ureteral duplication (HP:0000073)1.97146548
96Spinal muscular atrophy (HP:0007269)1.96962884
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.96083948
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96076557
99Overlapping toe (HP:0001845)1.95793623
100Abnormal lung lobation (HP:0002101)1.95006414
101High anterior hairline (HP:0009890)1.93119228
102Embryonal neoplasm (HP:0002898)1.92151230
103Cholecystitis (HP:0001082)1.91894955
104Abnormal gallbladder physiology (HP:0012438)1.91894955
105Amaurosis fugax (HP:0100576)1.91517526
106Postnatal microcephaly (HP:0005484)1.91508365
107Slender long bone (HP:0003100)1.90524322
108Hyperacusis (HP:0010780)1.89108558
109Abnormality of methionine metabolism (HP:0010901)1.87205385
110Triphalangeal thumb (HP:0001199)1.86970744
111Abnormality of the carotid arteries (HP:0005344)1.85650733
112CNS hypomyelination (HP:0003429)1.85156377
113Missing ribs (HP:0000921)1.84560808
114Spastic diplegia (HP:0001264)1.83604330
11511 pairs of ribs (HP:0000878)1.82992108
116Volvulus (HP:0002580)1.82004113
117Rib fusion (HP:0000902)1.81671897
118Cleft eyelid (HP:0000625)1.81477247
119Microglossia (HP:0000171)1.79907281
120Breast aplasia (HP:0100783)1.79854386
121Overriding aorta (HP:0002623)1.79783798
122Short humerus (HP:0005792)1.79710774
123Neoplasm of the adrenal cortex (HP:0100641)1.78758705
124Abnormality of the umbilical cord (HP:0010881)1.78255850
125Preauricular skin tag (HP:0000384)1.76807263
126Progressive muscle weakness (HP:0003323)1.76460154
127Choanal atresia (HP:0000453)1.76047391
128Personality changes (HP:0000751)1.75717449
129Reduced antithrombin III activity (HP:0001976)1.70878270
130Sparse eyelashes (HP:0000653)1.67249358
131Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67023702
132Neuroblastoma (HP:0003006)1.67023702
133Primitive neuroectodermal tumor (HP:0030065)1.67023702
134Neuroblastic tumors (HP:0004376)1.67023702
135Dysmetric saccades (HP:0000641)1.66203775
136Progressive hearing impairment (HP:0001730)1.65812616
137Insidious onset (HP:0003587)1.65134712
138Termporal pattern (HP:0011008)1.65134712
139Abnormality of the fetal cardiovascular system (HP:0010948)1.63669499
140Abnormal umbilical cord blood vessels (HP:0011403)1.63669499
141Single umbilical artery (HP:0001195)1.63669499
142Unilateral renal agenesis (HP:0000122)1.62396873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66137723
2WEE14.29800114
3CDC74.01853789
4EIF2AK13.32946651
5TSSK63.31818790
6PBK2.96752903
7NEK22.82819176
8SMG12.63971851
9SRPK12.53497889
10TTK2.48668479
11VRK22.43802296
12CDK122.40448247
13NEK12.22273584
14PLK42.10345656
15MKNK12.09833227
16PLK12.08886936
17MST42.05875486
18BRSK22.00251759
19PASK1.94294196
20TAF11.93163653
21EEF2K1.90518937
22PLK31.87283526
23CDK71.78217734
24MKNK21.77624086
25NME21.70677772
26AURKB1.69124785
27TESK21.66370657
28EPHA21.65405982
29RPS6KB21.64001127
30ATR1.61830293
31ACVR1B1.60233865
32ALK1.57604829
33EIF2AK31.52388099
34CDK41.52363750
35CHEK21.49548538
36CHEK11.49031639
37MAP3K81.46680276
38MST1R1.34946802
39RPS6KA41.34834077
40BRSK11.33070228
41STK101.32656476
42DYRK31.31942721
43AURKA1.27799270
44PNCK1.25783717
45TLK11.17809455
46VRK11.15186805
47LATS21.12026378
48STK161.11890539
49ICK1.11639194
50TRIM281.06013588
51SCYL21.03450364
52* CDK21.01968907
53PAK41.00173909
54MAP3K100.96184382
55ATM0.94863247
56PIM10.93168309
57TGFBR10.91323604
58BRD40.91224480
59CLK10.88368791
60PKN20.88015343
61PDK20.86018577
62PIM20.83509484
63IRAK30.81514399
64STK30.78864112
65STK40.78124002
66CSNK2A20.77785130
67STK38L0.77694678
68ERBB40.74762025
69PAK10.72970055
70MTOR0.71568925
71* CDK10.70839861
72CSNK1E0.70032382
73ZAK0.68970235
74AKT30.68246571
75CAMK1G0.67130506
76CCNB10.66535576
77CDK60.66415467
78NUAK10.65034036
79PRKCI0.64613999
80MAP4K10.64536475
81CSNK2A10.61112207
82MAP2K30.60916824
83CDK90.60160049
84MELK0.59756575
85PAK20.57855166
86CAMK1D0.57596766
87DAPK10.54980695
88MAP3K110.53901321
89LATS10.53247575
90AKT20.53204383
91LRRK20.51582910
92EIF2AK20.50930267
93FLT30.43678131
94MAP3K90.42154692
95BRAF0.40728015
96PRKDC0.40627936
97MET0.40351709
98CDK30.39769036
99TAOK20.35016084
100RPS6KA50.34994721
101RAF10.34795911
102TRIB30.34693246
103MAPKAPK30.33897792
104MAPKAPK50.33845916
105CSNK1D0.32687094
106CDK11A0.32388747
107* MAPK140.31344817
108CDK180.31293134
109CDK80.30549041
110FGFR10.30541241
111SIK30.29854194
112TAOK10.29494461
113CDK150.28711356
114NEK60.28409672
115PDK40.28381071
116PDK30.28381071
117GRK60.28130075
118RPS6KA10.26872810
119KDR0.25807580
120CDK140.25489207
121BCR0.24075179
122NME10.23849069
123GSK3B0.23741390
124AKT10.22626525
125TESK10.22516900
126RPS6KB10.21877904
127ZAP700.21409833
128MAPK10.20959290
129CHUK0.19190414

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60259057
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38681663
3Mismatch repair_Homo sapiens_hsa034304.03272076
4RNA transport_Homo sapiens_hsa030133.62741001
5Spliceosome_Homo sapiens_hsa030403.52207565
6RNA polymerase_Homo sapiens_hsa030203.44859546
7One carbon pool by folate_Homo sapiens_hsa006702.98968983
8Ribosome_Homo sapiens_hsa030102.96734208
9Cell cycle_Homo sapiens_hsa041102.84696227
10Base excision repair_Homo sapiens_hsa034102.82967518
11Nucleotide excision repair_Homo sapiens_hsa034202.78111760
12Proteasome_Homo sapiens_hsa030502.76424727
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74989236
14Homologous recombination_Homo sapiens_hsa034402.73425245
15Pyrimidine metabolism_Homo sapiens_hsa002402.33424763
16Fanconi anemia pathway_Homo sapiens_hsa034602.11358486
17mRNA surveillance pathway_Homo sapiens_hsa030152.04509690
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01952362
19RNA degradation_Homo sapiens_hsa030181.90112958
20Basal transcription factors_Homo sapiens_hsa030221.87352764
21Vitamin B6 metabolism_Homo sapiens_hsa007501.84294294
22Non-homologous end-joining_Homo sapiens_hsa034501.75788073
23p53 signaling pathway_Homo sapiens_hsa041151.72012507
24Epstein-Barr virus infection_Homo sapiens_hsa051691.30171016
25Pyruvate metabolism_Homo sapiens_hsa006201.27497947
26Purine metabolism_Homo sapiens_hsa002301.25516749
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16434466
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.11020545
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08969968
30Oocyte meiosis_Homo sapiens_hsa041141.07812044
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06068127
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03746855
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.02960175
34Viral carcinogenesis_Homo sapiens_hsa052031.01286596
35Protein export_Homo sapiens_hsa030600.97733949
36Antigen processing and presentation_Homo sapiens_hsa046120.92977432
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91812785
38Pentose phosphate pathway_Homo sapiens_hsa000300.89900229
39Herpes simplex infection_Homo sapiens_hsa051680.87502795
40Folate biosynthesis_Homo sapiens_hsa007900.86307564
41Systemic lupus erythematosus_Homo sapiens_hsa053220.84545316
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83957873
43HTLV-I infection_Homo sapiens_hsa051660.80547574
44MicroRNAs in cancer_Homo sapiens_hsa052060.77134420
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75646642
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.74020026
47Selenocompound metabolism_Homo sapiens_hsa004500.73578012
48Thyroid cancer_Homo sapiens_hsa052160.70411589
49Sulfur relay system_Homo sapiens_hsa041220.70100936
50Propanoate metabolism_Homo sapiens_hsa006400.66987517
51Steroid biosynthesis_Homo sapiens_hsa001000.66304815
52Small cell lung cancer_Homo sapiens_hsa052220.65815526
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59818635
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57738329
55Hippo signaling pathway_Homo sapiens_hsa043900.52124270
56Fatty acid elongation_Homo sapiens_hsa000620.50067591
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50012808
58Legionellosis_Homo sapiens_hsa051340.48934298
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47646321
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47637820
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47305183
62mTOR signaling pathway_Homo sapiens_hsa041500.46758201
63Carbon metabolism_Homo sapiens_hsa012000.46666999
64TGF-beta signaling pathway_Homo sapiens_hsa043500.43870453
65Apoptosis_Homo sapiens_hsa042100.43639821
66Huntingtons disease_Homo sapiens_hsa050160.43633557
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43173831
68Fatty acid biosynthesis_Homo sapiens_hsa000610.43158788
69Chronic myeloid leukemia_Homo sapiens_hsa052200.43135360
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42332614
71Bladder cancer_Homo sapiens_hsa052190.41383299
72Colorectal cancer_Homo sapiens_hsa052100.41244973
73Fructose and mannose metabolism_Homo sapiens_hsa000510.39428461
74HIF-1 signaling pathway_Homo sapiens_hsa040660.39216221
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.38839517
76Arginine biosynthesis_Homo sapiens_hsa002200.38503215
77Basal cell carcinoma_Homo sapiens_hsa052170.38191171
78Notch signaling pathway_Homo sapiens_hsa043300.37919095
79Fatty acid metabolism_Homo sapiens_hsa012120.36874642
80Pancreatic cancer_Homo sapiens_hsa052120.35795096
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32698225
82Acute myeloid leukemia_Homo sapiens_hsa052210.32161278
83Hepatitis B_Homo sapiens_hsa051610.32061241
84Primary immunodeficiency_Homo sapiens_hsa053400.31532109
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30495990
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30028193
87Metabolic pathways_Homo sapiens_hsa011000.29330296
88Glutathione metabolism_Homo sapiens_hsa004800.29060936
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.28892050
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28582615
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28451759
92Hedgehog signaling pathway_Homo sapiens_hsa043400.27723527
93Measles_Homo sapiens_hsa051620.26930399
94Prostate cancer_Homo sapiens_hsa052150.26666008
95Pathways in cancer_Homo sapiens_hsa052000.25678275
96Adherens junction_Homo sapiens_hsa045200.25068108
97Shigellosis_Homo sapiens_hsa051310.24083720
98Non-small cell lung cancer_Homo sapiens_hsa052230.22551612
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22021656
100Parkinsons disease_Homo sapiens_hsa050120.21020474
101Viral myocarditis_Homo sapiens_hsa054160.20522820
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20470700
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19098978
104Regulation of autophagy_Homo sapiens_hsa041400.18469610
105Alcoholism_Homo sapiens_hsa050340.18325780
106Lysine degradation_Homo sapiens_hsa003100.17282128
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16614399
108Galactose metabolism_Homo sapiens_hsa000520.16063506
109Influenza A_Homo sapiens_hsa051640.14689165
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14479865
111N-Glycan biosynthesis_Homo sapiens_hsa005100.14190568
112Wnt signaling pathway_Homo sapiens_hsa043100.13364221
113Glucagon signaling pathway_Homo sapiens_hsa049220.12596886
114Endometrial cancer_Homo sapiens_hsa052130.12582908
115Tight junction_Homo sapiens_hsa045300.11928764
116FoxO signaling pathway_Homo sapiens_hsa040680.11456561
117Melanoma_Homo sapiens_hsa052180.11438572
118Glioma_Homo sapiens_hsa052140.11079691
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10655627
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09804464
121Proteoglycans in cancer_Homo sapiens_hsa052050.09561400
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08257147
123Arginine and proline metabolism_Homo sapiens_hsa003300.07684499

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