NOM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.10106842
2DNA unwinding involved in DNA replication (GO:0006268)4.97201700
3mitotic sister chromatid cohesion (GO:0007064)4.93792601
4mitotic sister chromatid segregation (GO:0000070)4.71236558
5regulation of DNA endoreduplication (GO:0032875)4.67403916
6DNA replication checkpoint (GO:0000076)4.67402420
7DNA strand elongation involved in DNA replication (GO:0006271)4.66423755
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.62220544
9sister chromatid segregation (GO:0000819)4.56072986
10DNA strand elongation (GO:0022616)4.51628117
11ribosome assembly (GO:0042255)4.38792851
12regulation of translational fidelity (GO:0006450)4.16721404
13DNA strand renaturation (GO:0000733)4.10030729
14mitotic nuclear envelope disassembly (GO:0007077)4.09088434
15meiotic chromosome segregation (GO:0045132)3.99136551
16microtubule depolymerization (GO:0007019)3.94712646
17regulation of centrosome cycle (GO:0046605)3.93875059
18kinetochore organization (GO:0051383)3.93430068
19kinetochore assembly (GO:0051382)3.91514409
20telomere maintenance via semi-conservative replication (GO:0032201)3.90021744
21protein localization to chromosome, centromeric region (GO:0071459)3.86778786
22nuclear pore organization (GO:0006999)3.84182707
23DNA topological change (GO:0006265)3.84107068
24regulation of centrosome duplication (GO:0010824)3.83183288
25protein K6-linked ubiquitination (GO:0085020)3.76484334
26membrane disassembly (GO:0030397)3.76047225
27nuclear envelope disassembly (GO:0051081)3.76047225
28nuclear pore complex assembly (GO:0051292)3.73495067
29DNA duplex unwinding (GO:0032508)3.71836158
30DNA integration (GO:0015074)3.70935293
31regulation of RNA export from nucleus (GO:0046831)3.68730211
32G-protein coupled receptor internalization (GO:0002031)3.68299618
33ribosome biogenesis (GO:0042254)3.66745959
34folic acid-containing compound biosynthetic process (GO:0009396)3.66030666
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.64382420
36DNA geometric change (GO:0032392)3.62386120
37telomere maintenance via recombination (GO:0000722)3.62075548
38histone H3-K36 demethylation (GO:0070544)3.51491751
39protein localization to kinetochore (GO:0034501)3.49967650
40positive regulation of chromosome segregation (GO:0051984)3.49936380
41DNA synthesis involved in DNA repair (GO:0000731)3.49837977
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.49405372
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49405372
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49405372
45maturation of 5.8S rRNA (GO:0000460)3.48390917
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.45160936
47centriole assembly (GO:0098534)3.42914168
48pseudouridine synthesis (GO:0001522)3.42652006
49histone H3-K4 trimethylation (GO:0080182)3.41568810
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41243623
51mitotic recombination (GO:0006312)3.40792020
52DNA conformation change (GO:0071103)3.38641827
53regulation of translational termination (GO:0006449)3.36321990
54chromosome condensation (GO:0030261)3.33889944
55histone H3-K9 methylation (GO:0051567)3.33667959
56maturation of SSU-rRNA (GO:0030490)3.31459518
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.29887038
58negative regulation of keratinocyte proliferation (GO:0010839)3.29781264
59modulation by virus of host process (GO:0019054)3.27547876
60negative regulation of histone methylation (GO:0031061)3.27380864
61negative regulation of mRNA processing (GO:0050686)3.25025794
62DNA replication-dependent nucleosome assembly (GO:0006335)3.24504098
63DNA replication-dependent nucleosome organization (GO:0034723)3.24504098
64regulation of histone H3-K4 methylation (GO:0051569)3.23867175
65replicative senescence (GO:0090399)3.23472594
66folic acid metabolic process (GO:0046655)3.23429692
67negative regulation of granulocyte differentiation (GO:0030853)3.23381188
68peptidyl-lysine trimethylation (GO:0018023)3.20397970
69non-recombinational repair (GO:0000726)3.19990701
70double-strand break repair via nonhomologous end joining (GO:0006303)3.19990701
71nucleobase biosynthetic process (GO:0046112)3.19075098
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.17843742
73regulation of translation, ncRNA-mediated (GO:0045974)3.17843742
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17843742
75regulation of DNA damage checkpoint (GO:2000001)3.17094455
76tRNA methylation (GO:0030488)3.16829912
77transcription from mitochondrial promoter (GO:0006390)3.16198887
78pore complex assembly (GO:0046931)3.14899763
79negative regulation of mRNA metabolic process (GO:1903312)3.14567153
80translesion synthesis (GO:0019985)3.12153772
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.08550961
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08550961
83mismatch repair (GO:0006298)3.08456665
84DNA replication (GO:0006260)3.06501567
85reciprocal DNA recombination (GO:0035825)3.03309961
86reciprocal meiotic recombination (GO:0007131)3.03309961
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.02657811
88rRNA processing (GO:0006364)3.02585104
89rRNA transcription (GO:0009303)3.01876263
90DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.01735082
91mitochondrial RNA metabolic process (GO:0000959)3.01426858
92ribonucleoprotein complex biogenesis (GO:0022613)3.01343698
93DNA damage response, signal transduction resulting in transcription (GO:0042772)3.01285165
94nuclear envelope organization (GO:0006998)3.00537515
95chromatin assembly (GO:0031497)2.99546874
96IMP biosynthetic process (GO:0006188)2.98625865
97regulation of sister chromatid cohesion (GO:0007063)2.98588498
98superoxide anion generation (GO:0042554)2.98513472
99negative regulation of RNA splicing (GO:0033119)2.97694213
100DNA packaging (GO:0006323)2.97608411
101response to X-ray (GO:0010165)2.97552064
102telomere maintenance via telomere lengthening (GO:0010833)2.97260476
103tetrahydrofolate metabolic process (GO:0046653)2.96986725
104mRNA transport (GO:0051028)2.96953186
105regulation of helicase activity (GO:0051095)2.95079205
106rRNA metabolic process (GO:0016072)2.93884136
107snRNA transcription (GO:0009301)2.93779252
108heterochromatin organization (GO:0070828)2.93367272
109DNA ligation (GO:0006266)2.92909390
110formation of translation preinitiation complex (GO:0001731)2.92368931
111regulation of DNA-dependent DNA replication (GO:0090329)2.91702591
112inner cell mass cell proliferation (GO:0001833)2.88902028
113female gonad development (GO:0008585)2.88082687
114double-strand break repair via homologous recombination (GO:0000724)2.87382621
115chromosome segregation (GO:0007059)2.86487115
116telomere maintenance (GO:0000723)2.85317743
117CENP-A containing nucleosome assembly (GO:0034080)2.84770048
118regulation of nucleobase-containing compound transport (GO:0032239)2.84166874
119telomere organization (GO:0032200)2.84123378
120chromatin remodeling at centromere (GO:0031055)2.84104055
121recombinational repair (GO:0000725)2.84089770
122viral mRNA export from host cell nucleus (GO:0046784)2.82971219
123positive regulation of histone H3-K4 methylation (GO:0051571)2.81047305
124monoubiquitinated protein deubiquitination (GO:0035520)2.80397434
125RNA transport (GO:0050658)2.78468298
126establishment of RNA localization (GO:0051236)2.78468298
127nucleic acid transport (GO:0050657)2.78468298
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.78209520
129paraxial mesoderm development (GO:0048339)2.76612023
130histone H3-K4 methylation (GO:0051568)2.76387879
131centriole replication (GO:0007099)2.76376694
132mitotic metaphase plate congression (GO:0007080)2.76195868
133positive regulation of DNA-dependent DNA replication (GO:2000105)2.75382785
134cell proliferation in forebrain (GO:0021846)2.75370035
135mRNA splice site selection (GO:0006376)2.74646229
136histone H3-K9 modification (GO:0061647)2.73592238
137intra-S DNA damage checkpoint (GO:0031573)2.70520973
138telomere maintenance via telomerase (GO:0007004)2.69275834
139androgen biosynthetic process (GO:0006702)2.67357214
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62983056
141regulation of mitotic spindle checkpoint (GO:1903504)2.62983056
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62624129
143negative regulation of mast cell activation (GO:0033004)2.62454690
144phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.56734901
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56124833
146DNA replication initiation (GO:0006270)2.54139292
147cilium or flagellum-dependent cell motility (GO:0001539)2.49745536
148modulation by symbiont of host cellular process (GO:0044068)2.49625431
149DNA replication-independent nucleosome organization (GO:0034724)2.49220913
150DNA replication-independent nucleosome assembly (GO:0006336)2.49220913
151metaphase plate congression (GO:0051310)2.48975809
152regulation of NIK/NF-kappaB signaling (GO:1901222)2.48777752
153regulation of telomere maintenance (GO:0032204)2.48212548
154trophoblast giant cell differentiation (GO:0060707)2.48055600
155somatic recombination of immunoglobulin gene segments (GO:0016447)2.43653489
156positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.42986126
157positive regulation of interleukin-1 beta secretion (GO:0050718)2.41987780
158snRNA processing (GO:0016180)2.41458139
159regulation of double-strand break repair via homologous recombination (GO:0010569)2.37940259
160response to gamma radiation (GO:0010332)2.36851213
161regulation of histone H3-K9 methylation (GO:0051570)2.36560879
162response to UV-C (GO:0010225)2.35201724
163positive regulation of cellular amide metabolic process (GO:0034250)2.34871985
164synapsis (GO:0007129)2.34452480
165regulation of centriole replication (GO:0046599)2.33931386
166righting reflex (GO:0060013)2.33597261
167ncRNA catabolic process (GO:0034661)2.32649793
168DNA catabolic process, exonucleolytic (GO:0000738)2.32297728
169histone H2B ubiquitination (GO:0033523)2.31100643
170V(D)J recombination (GO:0033151)2.30765572
171microtubule anchoring (GO:0034453)2.29821916
172mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28458338
173mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28458338
174regulation of chromatin silencing (GO:0031935)2.26693862
175regulation of non-canonical Wnt signaling pathway (GO:2000050)2.26236897
176DNA alkylation (GO:0006305)2.25440466
177DNA methylation (GO:0006306)2.25440466
178histone lysine methylation (GO:0034968)2.24442631
179somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.24187687
180isotype switching (GO:0045190)2.24187687
181somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.24187687
182B cell homeostasis (GO:0001782)2.23884527
183sister chromatid cohesion (GO:0007062)2.23510970
184negative regulation of DNA replication (GO:0008156)2.22962456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18240702
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.75193753
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.31858945
4PCGF2_27294783_Chip-Seq_NPCs_Mouse3.13886299
5GBX2_23144817_ChIP-Seq_PC3_Human3.08915633
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03896155
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.01495290
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96849931
9NFE2_27457419_Chip-Seq_LIVER_Mouse2.95750806
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.94384627
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85740125
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.84589100
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69818014
14MYC_22102868_ChIP-Seq_BL_Human2.68039014
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61910331
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61468653
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.40877578
18EZH2_27294783_Chip-Seq_NPCs_Mouse2.38374321
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.38100532
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37696954
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37044538
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.36815223
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.35579303
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.33087241
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31254354
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31035571
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27212425
28* DCP1A_22483619_ChIP-Seq_HELA_Human2.25400713
29KDM5A_27292631_Chip-Seq_BREAST_Human2.14900316
30XRN2_22483619_ChIP-Seq_HELA_Human2.13052353
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07477793
32MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07076571
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05021494
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.03881628
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02027950
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.01736613
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99598942
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.99487717
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99213086
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.98256752
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97200730
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96280649
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.96024594
44P53_22387025_ChIP-Seq_ESCs_Mouse1.95814502
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.95634024
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95408492
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94043795
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93950574
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.93671518
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.93076589
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.91398901
52EWS_26573619_Chip-Seq_HEK293_Human1.91254640
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89241760
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.87872733
55* TTF2_22483619_ChIP-Seq_HELA_Human1.83853426
56* GABP_19822575_ChIP-Seq_HepG2_Human1.83356343
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83094174
58VDR_23849224_ChIP-Seq_CD4+_Human1.83004495
59IGF1R_20145208_ChIP-Seq_DFB_Human1.82993278
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81907700
61P300_18555785_Chip-Seq_ESCs_Mouse1.81829793
62FOXP3_21729870_ChIP-Seq_TREG_Human1.80375473
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.79983309
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.77996559
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.76713454
66AR_21909140_ChIP-Seq_LNCAP_Human1.76117096
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.75272479
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74091077
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.69826226
70ESRRB_18555785_Chip-Seq_ESCs_Mouse1.68649649
71PU1_27457419_Chip-Seq_LIVER_Mouse1.67776099
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.66167042
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66133435
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64902506
75CIITA_25753668_ChIP-Seq_RAJI_Human1.63933878
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63884647
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.63097735
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.62009367
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.59865710
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.58458760
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.58334176
82ELK1_19687146_ChIP-ChIP_HELA_Human1.57849161
83CTCF_18555785_Chip-Seq_ESCs_Mouse1.55695211
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52900832
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51667571
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50044771
87FUS_26573619_Chip-Seq_HEK293_Human1.49630417
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49415331
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48716249
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.48100825
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.47996135
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.44582302
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41663983
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41139670
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38652254
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32895422
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32649164
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31490907
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30018234
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29792194
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26675102
102VDR_21846776_ChIP-Seq_THP-1_Human1.26632856
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25738688
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25611462
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24486219
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21832067
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20267824
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20221036
109STAT3_23295773_ChIP-Seq_U87_Human1.18735190
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17645086
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16591178
112P300_19829295_ChIP-Seq_ESCs_Human1.15791604
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15634513
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15468474
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.14954798
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13270004
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.13254699
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12467046
119IRF1_19129219_ChIP-ChIP_H3396_Human1.12126463
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11613480
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11613480
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11267080
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09310624
124CHD1_26751641_Chip-Seq_LNCaP_Human1.07446033
125RNF2_27304074_Chip-Seq_NSC_Mouse1.06312053
126TCF4_23295773_ChIP-Seq_U87_Human1.05706703
127* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05077617
128* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04431946
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.04101583
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03673177
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02655660
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01827412
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01101605
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00799645
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00742670
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99083190
137TFEB_21752829_ChIP-Seq_HELA_Human0.98356660
138TP53_16413492_ChIP-PET_HCT116_Human0.98185565
139NCOR1_26117541_ChIP-Seq_K562_Human0.96229072
140SMAD4_21799915_ChIP-Seq_A2780_Human0.95169894
141EZH2_22144423_ChIP-Seq_EOC_Human0.93832997
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93530299
143TAF15_26573619_Chip-Seq_HEK293_Human0.93070816
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93040852
145TBL1_22424771_ChIP-Seq_293T_Human0.92847920
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92551639
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.90975052
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.90834382
149STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90648885
150TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89844513
151MYC_18940864_ChIP-ChIP_HL60_Human0.89664391
152KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89569533
153* RUNX2_22187159_ChIP-Seq_PCA_Human0.89332062
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89161968
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88955342
156CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88557906
157NFYB_21822215_ChIP-Seq_K562_Human0.88389755
158CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88185108
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88075027
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88039462
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87523914
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86813125
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86813125
164KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86813125
165CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86780858
166IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85998421
167ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84159608
168LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84120895
169ETV1_20927104_ChIP-Seq_GIST48_Human0.83472754
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77548730
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77106955
172* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76525113
173DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72774659
174MYB_26560356_Chip-Seq_TH1_Human0.72384354
175ZNF263_19887448_ChIP-Seq_K562_Human0.71396528
176HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70985214
177NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70099968
178FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.69501376
179ATF3_27146783_Chip-Seq_COLON_Human0.68739181
180ZNF274_21170338_ChIP-Seq_K562_Hela0.67034991
181KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.66489703
182* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.64298141
183KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.62903644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.15738987
2MP0008058_abnormal_DNA_repair3.93277008
3MP0008057_abnormal_DNA_replication3.72649697
4MP0003111_abnormal_nucleus_morphology3.40911588
5MP0006292_abnormal_olfactory_placode3.39236955
6MP0000566_synostosis3.32894672
7MP0010094_abnormal_chromosome_stability3.14247557
8MP0002102_abnormal_ear_morphology3.00541923
9MP0003136_yellow_coat_color2.75290660
10MP0003787_abnormal_imprinting2.60695189
11MP0002396_abnormal_hematopoietic_system2.58914888
12MP0002009_preneoplasia2.50985954
13MP0003941_abnormal_skin_development2.50907917
14MP0003693_abnormal_embryo_hatching2.45873746
15MP0000569_abnormal_digit_pigmentation2.29954917
16MP0002277_abnormal_respiratory_mucosa2.27982368
17MP0004381_abnormal_hair_follicle2.20285059
18MP0001730_embryonic_growth_arrest2.09926039
19MP0000015_abnormal_ear_pigmentation2.07051427
20MP0000383_abnormal_hair_follicle2.01337574
21MP0005076_abnormal_cell_differentiation1.92218384
22MP0003077_abnormal_cell_cycle1.91990515
23MP0008877_abnormal_DNA_methylation1.88898097
24MP0002132_abnormal_respiratory_system1.81759715
25MP0005174_abnormal_tail_pigmentation1.81498370
26MP0008995_early_reproductive_senescence1.78174563
27MP0005409_darkened_coat_color1.77587768
28MP0005451_abnormal_body_composition1.74574547
29MP0008007_abnormal_cellular_replicative1.73779158
30MP0003984_embryonic_growth_retardation1.71045876
31MP0001697_abnormal_embryo_size1.70005098
32MP0004185_abnormal_adipocyte_glucose1.68058568
33MP0000490_abnormal_crypts_of1.66755816
34MP0002877_abnormal_melanocyte_morpholog1.64277544
35MP0004233_abnormal_muscle_weight1.63467814
36MP0003786_premature_aging1.62855224
37MP0002088_abnormal_embryonic_growth/wei1.62576517
38MP0010352_gastrointestinal_tract_polyps1.53363167
39MP0003950_abnormal_plasma_membrane1.44768874
40MP0000427_abnormal_hair_cycle1.43846710
41MP0002080_prenatal_lethality1.43739119
42MP0000313_abnormal_cell_death1.43266096
43MP0005670_abnormal_white_adipose1.36598873
44MP0002084_abnormal_developmental_patter1.34163984
45MP0003121_genomic_imprinting1.32511673
46MP0010307_abnormal_tumor_latency1.31254070
47MP0002085_abnormal_embryonic_tissue1.30231631
48MP0004197_abnormal_fetal_growth/weight/1.30189718
49MP0003656_abnormal_erythrocyte_physiolo1.30065249
50MP0002086_abnormal_extraembryonic_tissu1.30002140
51MP0003828_pulmonary_edema1.29397701
52MP0001661_extended_life_span1.28748939
53MP0001346_abnormal_lacrimal_gland1.26688200
54MP0005075_abnormal_melanosome_morpholog1.24823233
55MP0005257_abnormal_intraocular_pressure1.22141094
56MP0009278_abnormal_bone_marrow1.16010319
57MP0006035_abnormal_mitochondrial_morpho1.13361553
58MP0004808_abnormal_hematopoietic_stem1.13156527
59MP0003763_abnormal_thymus_physiology1.10017690
60MP0005220_abnormal_exocrine_pancreas1.09219349
61MP0003705_abnormal_hypodermis_morpholog1.09200133
62MP0002019_abnormal_tumor_incidence1.06451520
63MP0005379_endocrine/exocrine_gland_phen1.06231354
64MP0005171_absent_coat_pigmentation1.04637353
65MP0004742_abnormal_vestibular_system1.02448684
66MP0008260_abnormal_autophagy1.02371567
67MP0002095_abnormal_skin_pigmentation1.02233835
68MP0001986_abnormal_taste_sensitivity1.01707504
69MP0003943_abnormal_hepatobiliary_system1.01222398
70MP0003718_maternal_effect0.99866977
71MP0002210_abnormal_sex_determination0.97997342
72MP0000358_abnormal_cell_content/0.96811238
73MP0001119_abnormal_female_reproductive0.96642006
74MP0001800_abnormal_humoral_immune0.95770848
75MP0002160_abnormal_reproductive_system0.94902981
76MP0008961_abnormal_basal_metabolism0.94084087
77MP0008932_abnormal_embryonic_tissue0.93892681
78MP0000703_abnormal_thymus_morphology0.92747449
79MP0001286_abnormal_eye_development0.91719218
80MP0000026_abnormal_inner_ear0.91574888
81MP0001873_stomach_inflammation0.91254820
82MP0009672_abnormal_birth_weight0.90852045
83MP0000432_abnormal_head_morphology0.89926803
84MP0000372_irregular_coat_pigmentation0.89708005
85MP0005389_reproductive_system_phenotype0.88942933
86MP0000579_abnormal_nail_morphology0.88218270
87MP0002970_abnormal_white_adipose0.86219595
88MP0001186_pigmentation_phenotype0.85282046
89MP0009697_abnormal_copulation0.84246330
90MP0003221_abnormal_cardiomyocyte_apopto0.82851542
91MP0001919_abnormal_reproductive_system0.82511186
92MP0000858_altered_metastatic_potential0.81950842
93MP0001929_abnormal_gametogenesis0.81770892
94MP0003890_abnormal_embryonic-extraembry0.80821376
95MP0010678_abnormal_skin_adnexa0.80477476
96MP0005266_abnormal_metabolism0.80203695
97MP0003938_abnormal_ear_development0.79595902
98MP0002111_abnormal_tail_morphology0.78191177
99MP0002075_abnormal_coat/hair_pigmentati0.77543975
100MP0002138_abnormal_hepatobiliary_system0.76885491
101MP0003878_abnormal_ear_physiology0.76527897
102MP0005377_hearing/vestibular/ear_phenot0.76527897
103MP0003806_abnormal_nucleotide_metabolis0.75475236
104MP0000428_abnormal_craniofacial_morphol0.75241071
105MP0002398_abnormal_bone_marrow0.74913651
106MP0003937_abnormal_limbs/digits/tail_de0.74723675
107MP0002751_abnormal_autonomic_nervous0.73959055
108MP0005621_abnormal_cell_physiology0.73533574
109MP0001293_anophthalmia0.73110333
110MP0002163_abnormal_gland_morphology0.72374873
111MP0003315_abnormal_perineum_morphology0.71848468
112MP0002177_abnormal_outer_ear0.71642433
113MP0002452_abnormal_antigen_presenting0.71623621
114MP0004019_abnormal_vitamin_homeostasis0.71377097
115MP0000371_diluted_coat_color0.71346753
116MP0001545_abnormal_hematopoietic_system0.71187324
117MP0005397_hematopoietic_system_phenotyp0.71187324
118MP0002697_abnormal_eye_size0.70423271
119MP0004043_abnormal_pH_regulation0.69998544
120MP0002938_white_spotting0.69946619
121MP0002269_muscular_atrophy0.69933761
122MP0005387_immune_system_phenotype0.69920632
123MP0001790_abnormal_immune_system0.69920632
124MP0000350_abnormal_cell_proliferation0.69737891
125MP0004133_heterotaxia0.69561891
126MP0005187_abnormal_penis_morphology0.68836599
127MP0000470_abnormal_stomach_morphology0.68793053
128MP0003646_muscle_fatigue0.68314263
129MP0002092_abnormal_eye_morphology0.68190100
130MP0005645_abnormal_hypothalamus_physiol0.68120475
131MP0000627_abnormal_mammary_gland0.67892761
132MP0001145_abnormal_male_reproductive0.67681588
133MP0001963_abnormal_hearing_physiology0.66419890
134MP0005384_cellular_phenotype0.65854774
135MP0009333_abnormal_splenocyte_physiolog0.65749298
136MP0002723_abnormal_immune_serum0.65489526
137MP0000613_abnormal_salivary_gland0.64255823
138MP0002638_abnormal_pupillary_reflex0.64186396
139MP0004957_abnormal_blastocyst_morpholog0.63769340
140MP0009703_decreased_birth_body0.63535924
141MP0004147_increased_porphyrin_level0.63422649
142MP0003755_abnormal_palate_morphology0.63312219
143MP0003936_abnormal_reproductive_system0.62818600
144MP0005380_embryogenesis_phenotype0.62698734
145MP0001672_abnormal_embryogenesis/_devel0.62698734
146MP0000462_abnormal_digestive_system0.62567325
147MP0002233_abnormal_nose_morphology0.61550709
148MP0003935_abnormal_craniofacial_develop0.61031433
149MP0002089_abnormal_postnatal_growth/wei0.59228040
150MP0000653_abnormal_sex_gland0.58984259
151MP0002006_tumorigenesis0.58660653
152MP0001216_abnormal_epidermal_layer0.56645348
153MP0002166_altered_tumor_susceptibility0.56572937
154MP0003699_abnormal_female_reproductive0.55862807

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)8.31100562
2Chromsome breakage (HP:0040012)7.64833620
3Duplicated collecting system (HP:0000081)5.33155068
4Abnormality of the renal collecting system (HP:0004742)4.90327523
5Prostate neoplasm (HP:0100787)4.43911459
6Progressive muscle weakness (HP:0003323)3.99420026
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.92660445
8Ectopic kidney (HP:0000086)3.84210849
9Upper limb muscle weakness (HP:0003484)3.83709587
10Abnormality of the preputium (HP:0100587)3.81677449
11Abnormality of DNA repair (HP:0003254)3.81194275
12Meckel diverticulum (HP:0002245)3.74308710
13Abnormality of chromosome stability (HP:0003220)3.64150876
14Abnormality of the ileum (HP:0001549)3.50449381
15Progressive external ophthalmoplegia (HP:0000590)3.21702087
16Urethral obstruction (HP:0000796)3.20029013
17Premature ovarian failure (HP:0008209)3.13394333
18Clubbing of toes (HP:0100760)3.04501113
19Abnormality of the carotid arteries (HP:0005344)2.81449426
20Squamous cell carcinoma (HP:0002860)2.79151046
21Febrile seizures (HP:0002373)2.77064614
22Duplication of thumb phalanx (HP:0009942)2.72132717
23Volvulus (HP:0002580)2.70513152
24Reticulocytopenia (HP:0001896)2.67536316
25Duodenal stenosis (HP:0100867)2.63998379
26Small intestinal stenosis (HP:0012848)2.63998379
27Hyperacusis (HP:0010780)2.61472770
28Abnormality of homocysteine metabolism (HP:0010919)2.53932487
29Homocystinuria (HP:0002156)2.53932487
30Birth length less than 3rd percentile (HP:0003561)2.53833027
31Septo-optic dysplasia (HP:0100842)2.52771952
32Abnormality of the prostate (HP:0008775)2.49731503
33Septate vagina (HP:0001153)2.49187879
34Prominent nose (HP:0000448)2.46410877
35High pitched voice (HP:0001620)2.42830512
36Anal stenosis (HP:0002025)2.40441533
37Clumsiness (HP:0002312)2.40216579
38Cafe-au-lait spot (HP:0000957)2.39835705
39Absent radius (HP:0003974)2.39575346
40High anterior hairline (HP:0009890)2.39248831
41Impulsivity (HP:0100710)2.37829784
42Abnormality of pyrimidine metabolism (HP:0004353)2.36688291
43Renal cortical cysts (HP:0000803)2.36061002
44Increased nuchal translucency (HP:0010880)2.35613887
45Nephroblastoma (Wilms tumor) (HP:0002667)2.33704745
46Breast hypoplasia (HP:0003187)2.33399821
47Mesomelia (HP:0003027)2.33084303
48Abnormality of the pons (HP:0007361)2.31509514
49Overlapping toe (HP:0001845)2.30456457
50Submucous cleft hard palate (HP:0000176)2.30312736
51Absent forearm bone (HP:0003953)2.29400382
52Aplasia involving forearm bones (HP:0009822)2.29400382
53Ureteral duplication (HP:0000073)2.28395283
54Ragged-red muscle fibers (HP:0003200)2.26783793
55Aplasia cutis congenita (HP:0001057)2.26480569
56Insomnia (HP:0100785)2.23618599
57Distal lower limb muscle weakness (HP:0009053)2.23065157
58Sandal gap (HP:0001852)2.21263407
59Short thumb (HP:0009778)2.20423807
60Hypoplasia of the pons (HP:0012110)2.20120085
61Embryonal renal neoplasm (HP:0011794)2.19306760
62Abnormality of the duodenum (HP:0002246)2.19160028
63Acute myeloid leukemia (HP:0004808)2.18649005
64Distal lower limb amyotrophy (HP:0008944)2.18330717
65Bone marrow hypocellularity (HP:0005528)2.18288497
66Triphalangeal thumb (HP:0001199)2.17250235
67Elfin facies (HP:0004428)2.16994063
68Dysmetric saccades (HP:0000641)2.16980127
69Absent thumb (HP:0009777)2.14887784
70Overriding aorta (HP:0002623)2.14121731
71Tubulointerstitial nephritis (HP:0001970)2.13209701
72Flat cornea (HP:0007720)2.10127634
73Osteomalacia (HP:0002749)2.10001419
74Lip pit (HP:0100267)2.06865038
75Myelodysplasia (HP:0002863)2.06557970
76Protruding tongue (HP:0010808)2.05493858
77Poikiloderma (HP:0001029)2.04439763
78Acute lymphatic leukemia (HP:0006721)2.04332411
79Ulnar bowing (HP:0003031)2.03986402
80Impaired proprioception (HP:0010831)2.01714982
81Fair hair (HP:0002286)1.99972702
82Patellar aplasia (HP:0006443)1.99599088
83Progressive inability to walk (HP:0002505)1.98033547
84Cerebellar dysplasia (HP:0007033)1.94481172
85Rectal prolapse (HP:0002035)1.94279713
86Microvesicular hepatic steatosis (HP:0001414)1.93432277
87Congenital stationary night blindness (HP:0007642)1.91001802
88Type II lissencephaly (HP:0007260)1.90729681
89Skull defect (HP:0001362)1.90577553
90Anal atresia (HP:0002023)1.89192881
91Abnormality of cells of the erythroid lineage (HP:0012130)1.89127116
92Short chin (HP:0000331)1.89019467
93Sensory axonal neuropathy (HP:0003390)1.88629893
94Abnormal number of erythroid precursors (HP:0012131)1.87719545
95Horseshoe kidney (HP:0000085)1.87604117
96Hypergonadotropic hypogonadism (HP:0000815)1.84088349
97Sloping forehead (HP:0000340)1.83141433
98Multiple enchondromatosis (HP:0005701)1.82984641
99Renovascular hypertension (HP:0100817)1.82101628
100Intestinal atresia (HP:0011100)1.81936569
101Partial agenesis of the corpus callosum (HP:0001338)1.81419151
102Pallor (HP:0000980)1.80769172
103Arteriovenous malformation (HP:0100026)1.77945530
104Low anterior hairline (HP:0000294)1.77122946
105Optic nerve hypoplasia (HP:0000609)1.75409662
106Abnormality of the incisor (HP:0000676)1.74668911
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74571077
108Aplasia/Hypoplasia of the patella (HP:0006498)1.74095016
109Abnormality of the labia minora (HP:0012880)1.73881173
110Wide intermamillary distance (HP:0006610)1.72697457
111Abnormality of the nasal septum (HP:0000419)1.72618955
112Tracheoesophageal fistula (HP:0002575)1.72541591
11311 pairs of ribs (HP:0000878)1.72536704
114Choanal atresia (HP:0000453)1.72179432
115Selective tooth agenesis (HP:0001592)1.71985385
116Abnormality of incisor morphology (HP:0011063)1.71081804
117Median cleft lip (HP:0000161)1.70562699
118Nephronophthisis (HP:0000090)1.70114810
119Atresia of the external auditory canal (HP:0000413)1.68010386
120Capillary hemangiomas (HP:0005306)1.66759477
121Proximal placement of thumb (HP:0009623)1.66225750
122Abnormality of the fingertips (HP:0001211)1.65857971
123Oligodactyly (hands) (HP:0001180)1.65617165
124Patellar dislocation (HP:0002999)1.64217112
125Ankyloglossia (HP:0010296)1.63411548
126Heterotopia (HP:0002282)1.63020673
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.62884567
128Intestinal fistula (HP:0100819)1.62586094
129Generalized hypopigmentation of hair (HP:0011358)1.62367611
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62185407
131Recurrent pneumonia (HP:0006532)1.60970200
132Obsessive-compulsive behavior (HP:0000722)1.60832846
133Abnormal number of incisors (HP:0011064)1.59786115
134Lower limb amyotrophy (HP:0007210)1.59638406
135Alveolar cell carcinoma (HP:0006519)1.58889887
136Abnormality of reticulocytes (HP:0004312)1.58253546
137Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58095266
138Leukopenia (HP:0001882)1.57869578
139Anomalous pulmonary venous return (HP:0010772)1.57594466
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.57523341
141Astigmatism (HP:0000483)1.56762725
142Long eyelashes (HP:0000527)1.55696553
143Optic neuritis (HP:0100653)1.55405077
144Retrobulbar optic neuritis (HP:0100654)1.55405077
145Abnormality of the renal medulla (HP:0100957)1.55126691
146Supernumerary bones of the axial skeleton (HP:0009144)1.54985686
147Facial cleft (HP:0002006)1.54642512
148Abnormality of the renal cortex (HP:0011035)1.54097279
149Oligohydramnios (HP:0001562)1.53958696
150Supernumerary spleens (HP:0009799)1.53957808
151Abnormality of male internal genitalia (HP:0000022)1.52696633
152Chin dimple (HP:0010751)1.51694754
153Recurrent cutaneous fungal infections (HP:0011370)1.50612679
154Chronic mucocutaneous candidiasis (HP:0002728)1.50612679
155Congenital sensorineural hearing impairment (HP:0008527)1.50242897
156Hypoplasia of the fovea (HP:0007750)1.49029248
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.49029248
158Supernumerary ribs (HP:0005815)1.48798383
159Azoospermia (HP:0000027)1.48377296
160Rib fusion (HP:0000902)1.48208878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.17448227
2CDK123.58676517
3CASK3.07138506
4ZAK2.98989130
5MKNK22.96766372
6EIF2AK22.85043269
7STK162.74869919
8TIE12.66771941
9BUB12.41497462
10GRK12.15308121
11SRPK12.14558689
12ICK2.13509214
13BRD42.10032971
14MST42.04855524
15CAMK1D2.03051000
16TXK2.02596099
17MKNK12.02313861
18MAP3K102.01235305
19IRAK31.98302823
20TRIB31.96589616
21TLK11.89857247
22EPHA21.86942043
23TTK1.86350054
24MAP3K141.78300585
25SMG11.76964674
26RPS6KB21.73045517
27TEC1.69656015
28CDC71.67467632
29BLK1.66720582
30WNK41.62296118
31AKT31.61097435
32YES11.55011463
33NUAK11.49509491
34INSRR1.48672598
35CAMK1G1.41306111
36PRPF4B1.39307992
37SGK21.37183605
38CLK11.34231175
39ATR1.33827913
40CHEK21.31176504
41PLK41.27941188
42LATS11.26162771
43CDK71.26029783
44NEK11.22382808
45ADRBK21.22204674
46PNCK1.21781199
47SIK21.21614862
48STK38L1.20140461
49TNIK1.18164770
50MTOR1.17425004
51PASK1.12902810
52NEK21.09461729
53STK41.09158310
54IRAK41.08360548
55MST1R1.07485170
56EPHA31.07351278
57RPS6KA41.05712963
58TAF11.04386936
59STK31.04156293
60CDK81.03022226
61MAPK111.02326131
62STK100.99278189
63SIK30.98189459
64NME20.98166064
65NEK60.96045613
66PLK10.93831893
67EIF2AK30.92175608
68CDK40.92024540
69ATM0.91647185
70MAPKAPK30.90891648
71MAP3K80.87066848
72AURKA0.85579065
73MAP2K70.84247032
74CHEK10.84231401
75CDK30.80600704
76TNK20.77328646
77AURKB0.74411362
78PBK0.73143021
79PIM10.70326897
80PLK30.69918100
81SGK30.69812712
82PKN10.67956887
83IKBKB0.67630584
84JAK30.67550591
85BRAF0.67207459
86CHUK0.66872777
87TAOK30.64306245
88JAK10.62843323
89MELK0.61925556
90BMPR20.59397607
91NLK0.59035188
92TSSK60.58202275
93TAOK20.57299633
94VRK10.56978222
95NME10.56448734
96DYRK30.56407217
97TRPM70.55954672
98ALK0.55585652
99WNK10.54044947
100CSNK1E0.53788118
101RAF10.53701005
102AKT20.53329466
103SGK10.53307765
104BRSK10.52808177
105RPS6KA50.52587410
106CDK60.52586499
107WEE10.51958837
108PRKAA20.50764986
109TTN0.49475159
110LMTK20.48854926
111ACVR1B0.48798629
112EIF2AK10.48315974
113AKT10.47040580
114CDK10.46780261
115SCYL20.46726575
116IKBKE0.46308195
117HCK0.46201392
118MET0.45962236
119FRK0.45340536
120MAPK140.44585498
121LYN0.44381645
122ERBB40.44201883
123PIK3CG0.43525488
124CDK20.43307260
125RIPK40.43085524
126GRK70.42109258
127NTRK30.41532683
128BRSK20.41513460
129CSNK2A20.37964453
130BMX0.36169228
131MARK30.35667837
132MAPKAPK50.35653048
133BMPR1B0.33484752
134MAPK70.32926021
135PRKDC0.32701204
136FGFR10.32668520
137GSK3B0.32667394
138MAP3K130.32370778
139PRKCI0.32079648
140BTK0.31715122
141STK390.31401671
142SGK4940.30655283
143SGK2230.30655283
144CDK90.30409253
145RPS6KB10.29586269
146MAPK100.29160942

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.89577677
2Non-homologous end-joining_Homo sapiens_hsa034502.95868213
3Homologous recombination_Homo sapiens_hsa034402.90825569
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61896526
5Selenocompound metabolism_Homo sapiens_hsa004502.51539838
6One carbon pool by folate_Homo sapiens_hsa006702.42398045
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.08996631
8Mismatch repair_Homo sapiens_hsa034302.07788503
9DNA replication_Homo sapiens_hsa030301.94212341
10Cell cycle_Homo sapiens_hsa041101.91796317
11Base excision repair_Homo sapiens_hsa034101.85129581
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84697670
13Basal transcription factors_Homo sapiens_hsa030221.69517641
14Lysine degradation_Homo sapiens_hsa003101.68578416
15Nucleotide excision repair_Homo sapiens_hsa034201.54320328
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53620561
17p53 signaling pathway_Homo sapiens_hsa041151.49341445
18Herpes simplex infection_Homo sapiens_hsa051681.46727555
19RNA polymerase_Homo sapiens_hsa030201.41998840
20Primary immunodeficiency_Homo sapiens_hsa053401.40196224
21Measles_Homo sapiens_hsa051621.40152174
22Hematopoietic cell lineage_Homo sapiens_hsa046401.39965401
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39137594
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34686424
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.33458917
26Pyrimidine metabolism_Homo sapiens_hsa002401.31593117
27Systemic lupus erythematosus_Homo sapiens_hsa053221.30088686
28Spliceosome_Homo sapiens_hsa030401.27696444
29mRNA surveillance pathway_Homo sapiens_hsa030151.27557147
30Bladder cancer_Homo sapiens_hsa052191.26906883
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26561610
32RNA transport_Homo sapiens_hsa030131.26408589
33RNA degradation_Homo sapiens_hsa030181.26083203
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26074628
35Vitamin digestion and absorption_Homo sapiens_hsa049771.25205771
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.22666860
37Sulfur relay system_Homo sapiens_hsa041221.19875793
38Chronic myeloid leukemia_Homo sapiens_hsa052201.19190007
39Autoimmune thyroid disease_Homo sapiens_hsa053201.18441192
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12644053
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12407918
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12111306
43Thyroid cancer_Homo sapiens_hsa052161.11582842
44Phototransduction_Homo sapiens_hsa047441.10322658
45MicroRNAs in cancer_Homo sapiens_hsa052061.05658912
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03899209
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.99113071
48Allograft rejection_Homo sapiens_hsa053300.98954125
49Small cell lung cancer_Homo sapiens_hsa052220.97327254
50Nicotine addiction_Homo sapiens_hsa050330.95149696
51Ribosome_Homo sapiens_hsa030100.94076600
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93654404
53Basal cell carcinoma_Homo sapiens_hsa052170.92895436
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86856964
55Purine metabolism_Homo sapiens_hsa002300.86751277
56Non-small cell lung cancer_Homo sapiens_hsa052230.84010768
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83846676
58Influenza A_Homo sapiens_hsa051640.80781621
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79249178
60HTLV-I infection_Homo sapiens_hsa051660.77712874
61Taste transduction_Homo sapiens_hsa047420.76949780
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76136081
63Prostate cancer_Homo sapiens_hsa052150.75681307
64Pancreatic cancer_Homo sapiens_hsa052120.75501424
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75269289
66Inositol phosphate metabolism_Homo sapiens_hsa005620.74887447
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74807848
68Viral carcinogenesis_Homo sapiens_hsa052030.72793702
69Asthma_Homo sapiens_hsa053100.72446098
70Epstein-Barr virus infection_Homo sapiens_hsa051690.70217883
71Sphingolipid metabolism_Homo sapiens_hsa006000.69706887
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68526570
73Graft-versus-host disease_Homo sapiens_hsa053320.68341940
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68226228
75Ovarian steroidogenesis_Homo sapiens_hsa049130.66871227
76Wnt signaling pathway_Homo sapiens_hsa043100.66853713
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66518161
78mTOR signaling pathway_Homo sapiens_hsa041500.65846309
79Biosynthesis of amino acids_Homo sapiens_hsa012300.65444655
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.65360779
81Hepatitis B_Homo sapiens_hsa051610.65042325
82T cell receptor signaling pathway_Homo sapiens_hsa046600.64313953
83Arachidonic acid metabolism_Homo sapiens_hsa005900.64290852
84Colorectal cancer_Homo sapiens_hsa052100.64017657
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63462968
86TNF signaling pathway_Homo sapiens_hsa046680.62997107
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62170199
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62162670
89Notch signaling pathway_Homo sapiens_hsa043300.58579807
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58001363
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57138338
92Melanoma_Homo sapiens_hsa052180.54433504
93Oocyte meiosis_Homo sapiens_hsa041140.52813742
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51554095
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.51130199
96ABC transporters_Homo sapiens_hsa020100.50902854
97Hepatitis C_Homo sapiens_hsa051600.50217190
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50183150
99Apoptosis_Homo sapiens_hsa042100.49838558
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47702090
101N-Glycan biosynthesis_Homo sapiens_hsa005100.47565660
102Osteoclast differentiation_Homo sapiens_hsa043800.46509727
103Leishmaniasis_Homo sapiens_hsa051400.44482370
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44217790
105FoxO signaling pathway_Homo sapiens_hsa040680.43608814
106B cell receptor signaling pathway_Homo sapiens_hsa046620.43552827
107Acute myeloid leukemia_Homo sapiens_hsa052210.42588533
108Chemokine signaling pathway_Homo sapiens_hsa040620.40353918
109Pathways in cancer_Homo sapiens_hsa052000.40263131
110ECM-receptor interaction_Homo sapiens_hsa045120.40177513
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40054870
112Axon guidance_Homo sapiens_hsa043600.39456147
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39089074
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.38773861
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.36160584
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.36002352
117Malaria_Homo sapiens_hsa051440.35991055
118Calcium signaling pathway_Homo sapiens_hsa040200.35580950
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35303025
120Circadian rhythm_Homo sapiens_hsa047100.35293213
121TGF-beta signaling pathway_Homo sapiens_hsa043500.34447497
122Adherens junction_Homo sapiens_hsa045200.34406300
123Pyruvate metabolism_Homo sapiens_hsa006200.34144416
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33732466
125Other glycan degradation_Homo sapiens_hsa005110.33587713
126Retinol metabolism_Homo sapiens_hsa008300.33402123
127Insulin resistance_Homo sapiens_hsa049310.33032932
128Prolactin signaling pathway_Homo sapiens_hsa049170.32697220
129Renal cell carcinoma_Homo sapiens_hsa052110.32542154
130Vitamin B6 metabolism_Homo sapiens_hsa007500.32268641
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.30767952
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30592054
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30498600
134Hippo signaling pathway_Homo sapiens_hsa043900.30052392
135AMPK signaling pathway_Homo sapiens_hsa041520.29983179
136ErbB signaling pathway_Homo sapiens_hsa040120.29632948
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27991501
138Insulin signaling pathway_Homo sapiens_hsa049100.27761145
139Glioma_Homo sapiens_hsa052140.26879851
140Carbon metabolism_Homo sapiens_hsa012000.25255235
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24852789
142Pentose phosphate pathway_Homo sapiens_hsa000300.23806509
143Dorso-ventral axis formation_Homo sapiens_hsa043200.22166448
144Endometrial cancer_Homo sapiens_hsa052130.19782507
145Alcoholism_Homo sapiens_hsa050340.19706878

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »