NOMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.54303924
2COPI coating of Golgi vesicle (GO:0048205)5.54303924
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.84834298
4protein retention in ER lumen (GO:0006621)4.75843352
5cytoskeletal anchoring at plasma membrane (GO:0007016)4.62615988
6basement membrane organization (GO:0071711)4.06413511
7sodium ion export (GO:0071436)3.96990189
8layer formation in cerebral cortex (GO:0021819)3.90086163
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.86266610
10plasma membrane repair (GO:0001778)3.81198928
11skin morphogenesis (GO:0043589)3.79525017
12cell adhesion mediated by integrin (GO:0033627)3.78355490
13protein localization to endosome (GO:0036010)3.76455735
14proline biosynthetic process (GO:0006561)3.72389087
15negative regulation of fibrinolysis (GO:0051918)3.67194667
16peptidyl-glutamic acid carboxylation (GO:0017187)3.57015835
17protein carboxylation (GO:0018214)3.57015835
18regulation of cholesterol homeostasis (GO:2000188)3.36034710
19very-low-density lipoprotein particle assembly (GO:0034379)3.33852827
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29827477
21COPII vesicle coating (GO:0048208)3.28810322
22regulation of translational fidelity (GO:0006450)3.21717405
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20304066
24regulation of apoptotic cell clearance (GO:2000425)3.14378274
25desmosome organization (GO:0002934)3.14057313
26vesicle coating (GO:0006901)3.13090294
27activation of protein kinase A activity (GO:0034199)3.11071160
28regulation of early endosome to late endosome transport (GO:2000641)3.10295930
29protein maturation by protein folding (GO:0022417)3.08833459
30regulation of cholesterol biosynthetic process (GO:0045540)3.08049837
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.06652982
32hemidesmosome assembly (GO:0031581)3.05228757
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.04327293
34pinocytosis (GO:0006907)3.02978699
35locomotory exploration behavior (GO:0035641)3.01313231
36adherens junction assembly (GO:0034333)3.00168062
37vocalization behavior (GO:0071625)2.99665330
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.99004188
39regulation of fibrinolysis (GO:0051917)2.98658963
40regulation of plasminogen activation (GO:0010755)2.95185251
41negative regulation of cell size (GO:0045792)2.94162465
42negative regulation of potassium ion transmembrane transport (GO:1901380)2.92508594
43endodermal cell differentiation (GO:0035987)2.91847087
44proline metabolic process (GO:0006560)2.91279650
45positive regulation of histone deacetylation (GO:0031065)2.91103326
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90752398
47protein-lipid complex assembly (GO:0065005)2.90509025
48mating behavior (GO:0007617)2.90507430
49plasma lipoprotein particle assembly (GO:0034377)2.88141346
50endoplasmic reticulum unfolded protein response (GO:0030968)2.87137886
51positive regulation of extracellular matrix organization (GO:1903055)2.86490556
524-hydroxyproline metabolic process (GO:0019471)2.85099493
53cellular potassium ion homeostasis (GO:0030007)2.84496604
54cell-substrate adherens junction assembly (GO:0007045)2.83091395
55focal adhesion assembly (GO:0048041)2.83091395
56low-density lipoprotein particle clearance (GO:0034383)2.81730621
57positive regulation of fibroblast migration (GO:0010763)2.80279594
58apoptotic cell clearance (GO:0043277)2.79886271
59ER-nucleus signaling pathway (GO:0006984)2.79862319
60cellular response to prostaglandin stimulus (GO:0071379)2.79380076
61dendritic spine morphogenesis (GO:0060997)2.77972913
62regulation of translational termination (GO:0006449)2.76167540
63regulation of nuclease activity (GO:0032069)2.74635520
64cell communication by electrical coupling (GO:0010644)2.74446487
65cell communication involved in cardiac conduction (GO:0086065)2.73453772
66glucose 6-phosphate metabolic process (GO:0051156)2.72911913
67cell-substrate junction assembly (GO:0007044)2.71250056
68sarcomere organization (GO:0045214)2.70244336
69positive regulation of hormone biosynthetic process (GO:0046886)2.69704729
70positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68102280
71planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66523597
72cellular response to unfolded protein (GO:0034620)2.65239891
73regulation of extracellular matrix disassembly (GO:0010715)2.63319367
74chondrocyte proliferation (GO:0035988)2.63064832
75peptidyl-proline hydroxylation (GO:0019511)2.60939580
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.60478608
77neuromuscular junction development (GO:0007528)2.58992418
78branching involved in mammary gland duct morphogenesis (GO:0060444)2.57591811
79embryonic process involved in female pregnancy (GO:0060136)2.57008040
80activation of Rac GTPase activity (GO:0032863)2.56623007
81barbed-end actin filament capping (GO:0051016)2.55678687
82intestinal cholesterol absorption (GO:0030299)2.55511681
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.55360304
84regulation of the force of heart contraction (GO:0002026)2.54584741
85polarized epithelial cell differentiation (GO:0030859)2.53880972
86platelet degranulation (GO:0002576)2.53383136
87stress fiber assembly (GO:0043149)2.52546818
88nuclear pore complex assembly (GO:0051292)2.52053406
89cytoplasmic mRNA processing body assembly (GO:0033962)2.51923685
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51240268
91cardiac myofibril assembly (GO:0055003)2.51097190
92protein targeting to Golgi (GO:0000042)2.50054102
93protein hydroxylation (GO:0018126)2.49001940
94proline transport (GO:0015824)2.48260729
95positive regulation of hormone metabolic process (GO:0032352)2.48166954
96pre-miRNA processing (GO:0031054)2.47440519
97regulation of hippo signaling (GO:0035330)2.47163150
98regulation of clathrin-mediated endocytosis (GO:2000369)2.47123991
99dicarboxylic acid biosynthetic process (GO:0043650)2.46141660
100regulation of ARF protein signal transduction (GO:0032012)2.45915629
101synaptic vesicle maturation (GO:0016188)2.44517563
102semaphorin-plexin signaling pathway (GO:0071526)2.44513130
103negative regulation of microtubule polymerization (GO:0031115)2.44444603
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.44186142
105cerebellar Purkinje cell layer development (GO:0021680)2.43945623
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43480079
107cellular response to topologically incorrect protein (GO:0035967)2.41739575
108hypotonic response (GO:0006971)2.40332425
109cardiac muscle contraction (GO:0060048)2.39821973
110low-density lipoprotein particle remodeling (GO:0034374)2.39699122
111regulation of protein activation cascade (GO:2000257)2.39564310
112establishment of protein localization to Golgi (GO:0072600)2.39539602
113cellular zinc ion homeostasis (GO:0006882)2.39440367
114cellular response to epidermal growth factor stimulus (GO:0071364)2.39377672
115regulation of extracellular matrix organization (GO:1903053)2.39287506
116regulation of complement activation (GO:0030449)2.38791404
117endothelial cell morphogenesis (GO:0001886)2.38364716
118epithelial cell-cell adhesion (GO:0090136)2.37678345
119paraxial mesoderm development (GO:0048339)2.36293295
120cellular response to epinephrine stimulus (GO:0071872)2.35961496
121regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.35228654
122neuron recognition (GO:0008038)2.35209033
123receptor catabolic process (GO:0032801)2.34041917
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.33811738
125creatine metabolic process (GO:0006600)2.33544610
126neuromuscular process controlling balance (GO:0050885)2.33213614
127embryo implantation (GO:0007566)2.33123189
128positive regulation of endothelial cell apoptotic process (GO:2000353)2.32281610
129establishment of nucleus localization (GO:0040023)2.32275756
130hyaluronan catabolic process (GO:0030214)2.32271783
131negative regulation of organelle assembly (GO:1902116)2.32249515
132positive regulation of osteoblast proliferation (GO:0033690)2.32217135
133negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31603701
134potassium ion import (GO:0010107)2.31580503
135peptidyl-lysine dimethylation (GO:0018027)2.31457019
136activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30623612
137positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30563988
138endocardial cushion development (GO:0003197)2.29382271
139response to endoplasmic reticulum stress (GO:0034976)2.29072460
140negative regulation of nucleotide catabolic process (GO:0030812)2.28871424
141positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28708604
142mesodermal cell differentiation (GO:0048333)2.28425349
143heterochromatin organization (GO:0070828)2.28192888
144cellular copper ion homeostasis (GO:0006878)2.28182958
145apoptotic process involved in morphogenesis (GO:0060561)2.28034284
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.27432953
147hyaluronan metabolic process (GO:0030212)2.27164224
148nerve growth factor signaling pathway (GO:0038180)2.26445855
149regulation of ARF GTPase activity (GO:0032312)2.26122390
150glutamine family amino acid biosynthetic process (GO:0009084)2.25297703
151membrane protein ectodomain proteolysis (GO:0006509)2.24157270
152regulation of glutamate receptor signaling pathway (GO:1900449)2.24026614
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22385665
154regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.21521493
155L-serine transport (GO:0015825)2.21040484
156cellular response to nerve growth factor stimulus (GO:1990090)2.20392898
157response to nerve growth factor (GO:1990089)2.20392898
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.20201675
159positive regulation of synapse maturation (GO:0090129)2.18387633
160regulation of calcium ion transmembrane transport (GO:1903169)2.17315372
161regulation of calcium ion transmembrane transporter activity (GO:1901019)2.17315372
162regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.17296534
163regulation of cAMP-dependent protein kinase activity (GO:2000479)2.16800378
164negative regulation of fatty acid transport (GO:2000192)2.16631498
165negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.15537546
166glycine transport (GO:0015816)2.15276510
167intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.14908030
168neuron remodeling (GO:0016322)2.14629978
169ionotropic glutamate receptor signaling pathway (GO:0035235)2.14513302
170establishment of apical/basal cell polarity (GO:0035089)2.14172413
171adherens junction organization (GO:0034332)2.13898714
172positive regulation of nuclease activity (GO:0032075)2.13439931
173protein targeting to plasma membrane (GO:0072661)2.12041806
174membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.10752310
175axonal fasciculation (GO:0007413)2.09727603
176cell migration in hindbrain (GO:0021535)2.09654709
177glutamate secretion (GO:0014047)2.09065648
178organelle transport along microtubule (GO:0072384)2.07173735
179negative regulation of potassium ion transport (GO:0043267)2.07044705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.38020967
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.34608634
3ZNF263_19887448_ChIP-Seq_K562_Human3.12527715
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04263070
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.94684631
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.56553062
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.40858957
8E2F7_22180533_ChIP-Seq_HELA_Human2.38060869
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27482115
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23421617
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.21212467
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19137000
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15862139
14KDM2B_26808549_Chip-Seq_K562_Human2.13338192
15KDM2B_26808549_Chip-Seq_DND41_Human2.10578847
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.03563299
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02293695
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.97179770
19DROSHA_22980978_ChIP-Seq_HELA_Human1.92067659
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.88553982
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87736681
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87156150
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.85431585
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84918801
25AR_21909140_ChIP-Seq_LNCAP_Human1.82724139
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.81311127
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78942451
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78862694
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78257773
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.76396134
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76015380
32CLOCK_20551151_ChIP-Seq_293T_Human1.75967956
33LXR_22292898_ChIP-Seq_THP-1_Human1.74029816
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72495497
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70945403
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69494576
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68716278
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66278272
39GATA1_19941826_ChIP-Seq_K562_Human1.65745561
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65336535
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.64748408
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63557919
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63557919
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62623878
45RACK7_27058665_Chip-Seq_MCF-7_Human1.61988419
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61831783
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.60405622
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60258276
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.58903312
50* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58324967
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.57154366
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57072901
53CREB1_26743006_Chip-Seq_LNCaP_Human1.54224671
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53774797
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53302124
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.50242682
57MYC_22102868_ChIP-Seq_BL_Human1.49223883
58ZNF274_21170338_ChIP-Seq_K562_Hela1.47951716
59ATF3_27146783_Chip-Seq_COLON_Human1.47754671
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46721186
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46576427
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46102922
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46071130
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45894630
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.45417743
66TP53_22127205_ChIP-Seq_IMR90_Human1.44176470
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43716774
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43323437
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42778193
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41360943
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39122079
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38545333
73TCF7_22412390_ChIP-Seq_EML_Mouse1.38377775
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37636989
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36220064
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36015950
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35492434
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35399138
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.34866205
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34095182
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34016540
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33195117
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32891178
84TP53_16413492_ChIP-PET_HCT116_Human1.32564477
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.31774505
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31722562
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31591939
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31379882
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29872533
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.26835425
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26677097
92* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25933517
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25740232
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.24181768
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24089806
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24072319
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23409726
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22967377
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22112074
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.21836376
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.21836376
102RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21668952
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.21275812
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.20198065
105CTCF_27219007_Chip-Seq_Bcells_Human1.19569146
106REST_21632747_ChIP-Seq_MESCs_Mouse1.19044844
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18008439
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17143369
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17126457
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.17088523
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.16309326
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16233690
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15959485
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15233264
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14996101
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14891120
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14466477
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14037108
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12565858
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11467505
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10763754
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10704600
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10331892
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10266139
125ISL1_27105846_Chip-Seq_CPCs_Mouse1.10232414
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.09388171
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08597192
128LXR_22158963_ChIP-Seq_LIVER_Mouse1.07893170
129NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07861226
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07517344
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07284757
132RING1B_27294783_Chip-Seq_ESCs_Mouse1.07175376
133CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06492453
134TET1_21490601_ChIP-Seq_MESCs_Mouse1.05521705
135EZH2_27304074_Chip-Seq_ESCs_Mouse1.05297873
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04665618
137SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04083683
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03784639
139ESR1_20079471_ChIP-ChIP_T-47D_Human1.03395364
140RING1B_27294783_Chip-Seq_NPCs_Mouse1.02537262
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02144590
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02144590
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01406487
144TP63_22573176_ChIP-Seq_HFKS_Human0.99226514
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98625743
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98376395
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97586236
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.97249094
149P68_20966046_ChIP-Seq_HELA_Human0.96752524
150SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96464388
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96087795
152GATA2_19941826_ChIP-Seq_K562_Human0.95204761
153AR_19668381_ChIP-Seq_PC3_Human0.94510311
154KLF5_25053715_ChIP-Seq_YYC3_Human0.93909061
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.92005318
156WT1_19549856_ChIP-ChIP_CCG9911_Human0.91929795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.29299197
2MP0005623_abnormal_meninges_morphology3.26855648
3MP0000751_myopathy3.11491670
4MP0002837_dystrophic_cardiac_calcinosis2.83266204
5MP0003705_abnormal_hypodermis_morpholog2.77230671
6MP0005257_abnormal_intraocular_pressure2.68391768
7MP0005058_abnormal_lysosome_morphology2.52674746
8MP0004084_abnormal_cardiac_muscle2.38561323
9MP0005409_darkened_coat_color2.37138310
10MP0005451_abnormal_body_composition2.31164639
11MP0000747_muscle_weakness2.19856975
12MP0003283_abnormal_digestive_organ2.10823509
13MP0003635_abnormal_synaptic_transmissio2.06873708
14MP0004233_abnormal_muscle_weight2.05620248
15MP0003329_amyloid_beta_deposits2.04442164
16MP0003941_abnormal_skin_development1.99048902
17MP0001849_ear_inflammation1.98274158
18MP0010368_abnormal_lymphatic_system1.97088967
19MP0004185_abnormal_adipocyte_glucose1.93095692
20MP0009780_abnormal_chondrocyte_physiolo1.92791186
21MP0008961_abnormal_basal_metabolism1.92485241
22MP0004270_analgesia1.92162236
23MP0004036_abnormal_muscle_relaxation1.86506599
24MP0001915_intracranial_hemorrhage1.83665073
25MP0010234_abnormal_vibrissa_follicle1.81555748
26MP0004087_abnormal_muscle_fiber1.76853623
27MP0004145_abnormal_muscle_electrophysio1.74047982
28MP0004272_abnormal_basement_membrane1.73200787
29MP0001440_abnormal_grooming_behavior1.72753924
30MP0003566_abnormal_cell_adhesion1.66488502
31MP0005330_cardiomyopathy1.65438087
32MP0003300_gastrointestinal_ulcer1.61757699
33MP0000537_abnormal_urethra_morphology1.60544224
34MP0010352_gastrointestinal_tract_polyps1.60504709
35MP0004215_abnormal_myocardial_fiber1.59659667
36MP0009840_abnormal_foam_cell1.58706062
37MP0002909_abnormal_adrenal_gland1.56611883
38MP0002089_abnormal_postnatal_growth/wei1.54718619
39MP0000003_abnormal_adipose_tissue1.54606677
40MP0000750_abnormal_muscle_regeneration1.54493746
41MP0003172_abnormal_lysosome_physiology1.53629992
42MP0002877_abnormal_melanocyte_morpholog1.53356360
43MP0005375_adipose_tissue_phenotype1.52762817
44MP0002060_abnormal_skin_morphology1.51800613
45MP0004130_abnormal_muscle_cell1.51089882
46MP0000759_abnormal_skeletal_muscle1.50984941
47MP0002064_seizures1.50018242
48MP0008438_abnormal_cutaneous_collagen1.47450789
49MP0003880_abnormal_central_pattern1.46540579
50MP0006138_congestive_heart_failure1.46526631
51MP0005023_abnormal_wound_healing1.46455488
52MP0003950_abnormal_plasma_membrane1.46096529
53MP0002063_abnormal_learning/memory/cond1.45865909
54MP0009745_abnormal_behavioral_response1.44202455
55MP0005666_abnormal_adipose_tissue1.43566840
56MP0009046_muscle_twitch1.39876274
57MP0004858_abnormal_nervous_system1.38187884
58MP0001661_extended_life_span1.37574777
59MP0004484_altered_response_of1.37437230
60MP0000013_abnormal_adipose_tissue1.37431582
61MP0002269_muscular_atrophy1.37020603
62MP0002896_abnormal_bone_mineralization1.34450314
63MP0001958_emphysema1.32144182
64MP0000749_muscle_degeneration1.31473559
65MP0003279_aneurysm1.31154285
66MP0004264_abnormal_extraembryonic_tissu1.30978101
67MP0003123_paternal_imprinting1.28073741
68MP0002106_abnormal_muscle_physiology1.27685084
69MP0000767_abnormal_smooth_muscle1.26989111
70MP0000733_abnormal_muscle_development1.24856929
71MP0008775_abnormal_heart_ventricle1.23301683
72MP0001730_embryonic_growth_arrest1.19996598
73MP0001348_abnormal_lacrimal_gland1.19125568
74MP0003453_abnormal_keratinocyte_physiol1.18970735
75MP0008260_abnormal_autophagy1.18724877
76MP0000566_synostosis1.18074661
77MP0003942_abnormal_urinary_system1.17407823
78MP0010630_abnormal_cardiac_muscle1.15969077
79MP0000534_abnormal_ureter_morphology1.15841061
80MP0009672_abnormal_birth_weight1.15310837
81MP0004085_abnormal_heartbeat1.14025392
82MP0005360_urolithiasis1.12707014
83MP0003385_abnormal_body_wall1.12669043
84MP0005369_muscle_phenotype1.12653844
85MP0005620_abnormal_muscle_contractility1.12645294
86MP0004885_abnormal_endolymph1.12434975
87MP0002572_abnormal_emotion/affect_behav1.11902395
88MP0008770_decreased_survivor_rate1.09272076
89MP0003091_abnormal_cell_migration1.08975398
90MP0002234_abnormal_pharynx_morphology1.08143470
91MP0005187_abnormal_penis_morphology1.07935945
92MP0000762_abnormal_tongue_morphology1.07252474
93MP0003868_abnormal_feces_composition1.07198763
94MP0008569_lethality_at_weaning1.06823955
95MP0001727_abnormal_embryo_implantation1.06439281
96MP0006054_spinal_hemorrhage1.05987384
97MP0003115_abnormal_respiratory_system1.05956946
98MP0003137_abnormal_impulse_conducting1.05578092
99MP0002822_catalepsy1.04877454
100MP0005083_abnormal_biliary_tract1.04747499
101MP0001666_abnormal_nutrient_absorption1.01963657
102MP0003045_fibrosis1.01820485
103MP0002272_abnormal_nervous_system1.01716110
104MP0003221_abnormal_cardiomyocyte_apopto1.01478177
105MP0001501_abnormal_sleep_pattern1.01294162
106MP0005408_hypopigmentation0.98123088
107MP0010030_abnormal_orbit_morphology0.97684015
108MP0002086_abnormal_extraembryonic_tissu0.96722970
109MP0005621_abnormal_cell_physiology0.94189794
110MP0003122_maternal_imprinting0.94103910
111MP0000579_abnormal_nail_morphology0.93649221
112MP0002108_abnormal_muscle_morphology0.92568803
113MP0002972_abnormal_cardiac_muscle0.92098068
114MP0003646_muscle_fatigue0.91868899
115MP0003191_abnormal_cellular_cholesterol0.90945266
116MP0005076_abnormal_cell_differentiation0.90585414
117MP0000462_abnormal_digestive_system0.90289843
118MP0000858_altered_metastatic_potential0.89918472
119MP0005501_abnormal_skin_physiology0.89901573
120MP0003984_embryonic_growth_retardation0.87524406
121MP0001486_abnormal_startle_reflex0.87262061
122MP0001299_abnormal_eye_distance/0.87037111
123MP0000955_abnormal_spinal_cord0.85360578
124MP0004811_abnormal_neuron_physiology0.85183395
125MP0002733_abnormal_thermal_nociception0.84599437
126MP0002734_abnormal_mechanical_nocicepti0.84393134
127MP0005386_behavior/neurological_phenoty0.84049985
128MP0004924_abnormal_behavior0.84049985
129MP0002066_abnormal_motor_capabilities/c0.83627896
130MP0005380_embryogenesis_phenotype0.83623457
131MP0001672_abnormal_embryogenesis/_devel0.83623457
132MP0002088_abnormal_embryonic_growth/wei0.82159756
133MP0002152_abnormal_brain_morphology0.81284064
134MP0000678_abnormal_parathyroid_gland0.81106122
135MP0002080_prenatal_lethality0.81011673
136MP0005503_abnormal_tendon_morphology0.80437670
137MP0002184_abnormal_innervation0.80204474
138MP0001544_abnormal_cardiovascular_syste0.78842429
139MP0005385_cardiovascular_system_phenoty0.78842429
140MP0003634_abnormal_glial_cell0.75683932
141MP0003303_peritoneal_inflammation0.75548653
142MP0003959_abnormal_lean_body0.75426410
143MP0005508_abnormal_skeleton_morphology0.74856790
144MP0000428_abnormal_craniofacial_morphol0.74727970
145MP0002697_abnormal_eye_size0.74183259
146MP0000467_abnormal_esophagus_morphology0.73504252
147MP0002067_abnormal_sensory_capabilities0.73357733
148MP0002090_abnormal_vision0.73288751
149MP0005275_abnormal_skin_tensile0.73214338
150MP0005165_increased_susceptibility_to0.72677740
151MP0005384_cellular_phenotype0.72635424
152MP0005365_abnormal_bile_salt0.72308754
153MP0001614_abnormal_blood_vessel0.72269526
154MP0004510_myositis0.71998110
155MP0002796_impaired_skin_barrier0.71982556
156MP0009384_cardiac_valve_regurgitation0.71968167
157MP0000627_abnormal_mammary_gland0.71518181
158MP0003315_abnormal_perineum_morphology0.70972103

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.48958068
2Cerebral inclusion bodies (HP:0100314)3.43560655
3Dysmetric saccades (HP:0000641)3.26977616
4Vertebral compression fractures (HP:0002953)3.24253430
5Hyporeflexia of lower limbs (HP:0002600)3.17680200
6Difficulty climbing stairs (HP:0003551)3.16995517
7Upper limb amyotrophy (HP:0009129)3.08848686
8Distal upper limb amyotrophy (HP:0007149)3.08848686
9Asymmetry of the thorax (HP:0001555)3.03934189
10Difficulty running (HP:0009046)3.03823948
11Sudden death (HP:0001699)3.02556425
12Insidious onset (HP:0003587)2.95826132
13Termporal pattern (HP:0011008)2.95826132
14Arterial tortuosity (HP:0005116)2.95113159
15Cerebral aneurysm (HP:0004944)2.85396117
16Visual hallucinations (HP:0002367)2.82442546
17Achilles tendon contracture (HP:0001771)2.81842140
18Vascular tortuosity (HP:0004948)2.79743067
19Focal seizures (HP:0007359)2.78753331
20Increased connective tissue (HP:0009025)2.77904594
21Insomnia (HP:0100785)2.74629177
22Muscle fiber splitting (HP:0003555)2.73603305
23Increased variability in muscle fiber diameter (HP:0003557)2.73401069
24Abnormality of the lower motor neuron (HP:0002366)2.72512939
25Lower limb amyotrophy (HP:0007210)2.66859627
26Buphthalmos (HP:0000557)2.62832955
27Abnormality of carpal bone ossification (HP:0006257)2.61762711
28Exercise-induced muscle cramps (HP:0003710)2.59721087
29Resting tremor (HP:0002322)2.59197573
30Rapidly progressive (HP:0003678)2.58529305
31Shallow orbits (HP:0000586)2.55297757
32Hand muscle atrophy (HP:0009130)2.54088675
33Back pain (HP:0003418)2.54022700
34Wormian bones (HP:0002645)2.51591865
35Exercise-induced myalgia (HP:0003738)2.49196045
36Abnormality of the Achilles tendon (HP:0005109)2.47542351
37Abnormality of dentin (HP:0010299)2.47237246
38Distal lower limb amyotrophy (HP:0008944)2.46203749
39Hyperacusis (HP:0010780)2.44176763
40Aortic dissection (HP:0002647)2.43854668
41Mitral stenosis (HP:0001718)2.40222127
42Premature rupture of membranes (HP:0001788)2.38931912
43Cervical subluxation (HP:0003308)2.38909006
44Ankle contracture (HP:0006466)2.37638440
45Small epiphyses (HP:0010585)2.37533092
46Abnormality of the acetabulum (HP:0003170)2.36762558
47Scapular winging (HP:0003691)2.35924869
48Renal duplication (HP:0000075)2.33790334
49Right ventricular cardiomyopathy (HP:0011663)2.32467920
50Abnormal ossification of hand bones (HP:0005921)2.32137115
51Abnormality of skeletal muscle fiber size (HP:0012084)2.30173458
52Protrusio acetabuli (HP:0003179)2.25745902
53Abnormality of the calf musculature (HP:0001430)2.25583206
54Muscle hypertrophy of the lower extremities (HP:0008968)2.21658981
55Calf muscle hypertrophy (HP:0008981)2.21553649
56Atrophic scars (HP:0001075)2.20006227
57EMG: myopathic abnormalities (HP:0003458)2.19936914
58Abnormality of the common coagulation pathway (HP:0010990)2.18889928
59Hemiparesis (HP:0001269)2.17086785
60Abnormal social behavior (HP:0012433)2.16360142
61Impaired social interactions (HP:0000735)2.16360142
62Mildly elevated creatine phosphokinase (HP:0008180)2.15354122
63Supranuclear gaze palsy (HP:0000605)2.14824914
64Menorrhagia (HP:0000132)2.14349550
65Blue sclerae (HP:0000592)2.13608335
66Biconcave vertebral bodies (HP:0004586)2.09543509
67Hypercholesterolemia (HP:0003124)2.09537741
68Ankyloglossia (HP:0010296)2.08572803
69Neurofibrillary tangles (HP:0002185)2.07292361
70Cardiovascular calcification (HP:0011915)2.07266305
71Aortic aneurysm (HP:0004942)2.04994386
72Disproportionate tall stature (HP:0001519)2.04961287
73Limb-girdle muscle atrophy (HP:0003797)2.03754113
74Hemorrhage of the eye (HP:0011885)2.03020958
75Bundle branch block (HP:0011710)2.01331201
76Elbow flexion contracture (HP:0002987)2.01148933
77Abnormality of oral frenula (HP:0000190)2.01028417
78Abnormal delivery (HP:0001787)2.00761169
79Advanced eruption of teeth (HP:0006288)1.99649511
80Coxa vara (HP:0002812)1.99552257
81Reticulocytosis (HP:0001923)1.99279247
82Poor eye contact (HP:0000817)1.99148950
83Ventricular tachycardia (HP:0004756)1.98100522
84Global brain atrophy (HP:0002283)1.97308365
85Impaired pain sensation (HP:0007328)1.96565430
86Abnormality of pain sensation (HP:0010832)1.96565430
87Short nail (HP:0001799)1.95356653
88Macroorchidism (HP:0000053)1.94245613
89Bladder diverticulum (HP:0000015)1.93961388
90Bronchomalacia (HP:0002780)1.93130433
91Genu recurvatum (HP:0002816)1.93058325
92Neonatal death (HP:0003811)1.92274830
93Congenital glaucoma (HP:0001087)1.91974399
94Mitral regurgitation (HP:0001653)1.91337887
95Ventricular fibrillation (HP:0001663)1.91006130
96EMG: neuropathic changes (HP:0003445)1.90869476
97Vascular calcification (HP:0004934)1.89777472
98Abnormality of binocular vision (HP:0011514)1.89052713
99Diplopia (HP:0000651)1.89052713
100Broad face (HP:0000283)1.87752232
101Generalized tonic-clonic seizures (HP:0002069)1.86353761
102Cupped ribs (HP:0000887)1.85708607
103Limb-girdle muscle weakness (HP:0003325)1.84258311
104Neonatal short-limb short stature (HP:0008921)1.84115088
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84085250
106Abnormal hand bone ossification (HP:0010660)1.84058439
107Increased density of long bones (HP:0006392)1.83673384
108Distal lower limb muscle weakness (HP:0009053)1.83208150
109Ulnar bowing (HP:0003031)1.82921585
110Abnormality of the astrocytes (HP:0100707)1.82261743
111Astrocytoma (HP:0009592)1.82261743
112Hemiplegia (HP:0002301)1.81996837
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.81484568
114Broad palm (HP:0001169)1.80568962
115Fragile skin (HP:0001030)1.80037287
116Urinary urgency (HP:0000012)1.80006795
117Myotonia (HP:0002486)1.79839460
118Hammertoe (HP:0001765)1.78955746
119Hypercortisolism (HP:0001578)1.78837581
120Lymphangioma (HP:0100764)1.78560008
121Dysdiadochokinesis (HP:0002075)1.78334992
122Prolonged partial thromboplastin time (HP:0003645)1.77827309
123Type 1 muscle fiber predominance (HP:0003803)1.77604309
124Neuronal loss in central nervous system (HP:0002529)1.77018692
125Myocardial infarction (HP:0001658)1.76415003
126Osteolytic defects of the hand bones (HP:0009699)1.76026382
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.76026382
128Thin bony cortex (HP:0002753)1.75982283
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75790999
130Aneurysm (HP:0002617)1.74998478
131Neoplasm of the heart (HP:0100544)1.74523195
132Flat acetabular roof (HP:0003180)1.74403644
133Pterygium (HP:0001059)1.73975734
134Broad metatarsal (HP:0001783)1.73735483
135Spinal rigidity (HP:0003306)1.73696080
136Skin nodule (HP:0200036)1.73654176
137Turricephaly (HP:0000262)1.73034574
138Hyperextensible skin (HP:0000974)1.72872732
139Round ear (HP:0100830)1.71936544
140Arnold-Chiari malformation (HP:0002308)1.71732605
141Syncope (HP:0001279)1.71690871
142Soft skin (HP:0000977)1.71409906
143Myoglobinuria (HP:0002913)1.70026930
144Natal tooth (HP:0000695)1.69453470
145Hamartoma of the eye (HP:0010568)1.69153013
146Pseudobulbar signs (HP:0002200)1.68878035
147Slender build (HP:0001533)1.68825150
148Bowel diverticulosis (HP:0005222)1.67420621
149Focal motor seizures (HP:0011153)1.67248927
150Overriding aorta (HP:0002623)1.66533252
151Premature skin wrinkling (HP:0100678)1.66531339
152Mitral valve prolapse (HP:0001634)1.66014041
153Abnormality of the corticospinal tract (HP:0002492)1.65547001
154Joint hemorrhage (HP:0005261)1.65504267
155Heterotopia (HP:0002282)1.65256310
156Limited elbow extension (HP:0001377)1.64799858
157Athetosis (HP:0002305)1.64765034
158Vertebral arch anomaly (HP:0008438)1.64524533
159Atonic seizures (HP:0010819)1.64491184
160J-shaped sella turcica (HP:0002680)1.63067539
161Dilatation of the ascending aorta (HP:0005111)1.62291620
162Joint laxity (HP:0001388)1.61614424
163Xanthomatosis (HP:0000991)1.61098407
164Abnormality of complement system (HP:0005339)1.58509965
165Generalized amyotrophy (HP:0003700)1.58479433
166Trismus (HP:0000211)1.56462900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.27129063
2EEF2K3.43989331
3PKN23.36539217
4FGFR43.06181382
5TTN2.97503069
6SMG12.60574409
7PNCK2.48159418
8ICK2.39501145
9MAP3K92.14223436
10SCYL22.09126591
11IRAK32.07270793
12CAMK1G1.94974231
13RIPK11.93163650
14MST1R1.89503742
15ALK1.81272725
16NTRK31.74655788
17PAK61.68996723
18CDK121.66332497
19BMX1.61280768
20NTRK11.57530341
21PAK21.54228732
22PDGFRA1.54155572
23PRKD31.51969346
24LMTK21.50207966
25FGFR31.49608455
26DDR21.47710122
27EPHB11.44807768
28TYRO31.41294446
29PRPF4B1.40478650
30KSR21.39552646
31PTK61.39486767
32LATS21.37909946
33SIK21.33005071
34DMPK1.31635769
35CAMK1D1.29994472
36MAP3K41.28943455
37PTK21.23884768
38PAK31.23548360
39RET1.19905381
40LATS11.19731327
41TESK11.17286055
42MTOR1.15254953
43CAMKK11.09871487
44MAP3K101.05425279
45ARAF1.03894107
46SIK11.03799922
47PHKG21.03764533
48PHKG11.03764533
49ROCK21.01188746
50EIF2AK10.99296984
51WNK10.98499651
52NME20.97768898
53FER0.96275857
54EPHA40.95659461
55EPHA20.93322338
56MAPKAPK30.91582155
57PDK30.90540509
58PDK40.90540509
59PTK2B0.87129591
60STK110.86096336
61TAOK10.84745717
62MINK10.82023582
63MAP3K70.81057664
64UHMK10.79584873
65ERBB40.79067166
66CDK70.78669101
67MAP3K130.77665431
68CDK50.76022272
69MAP2K40.74608453
70PDGFRB0.74597001
71FGR0.73765435
72LIMK10.73719283
73MET0.72891103
74RPS6KA20.71696163
75NEK90.70552453
76MARK20.70232678
77PDPK10.69765755
78LRRK20.69650697
79MAPK110.69632524
80CSNK1E0.69453265
81STK390.69385881
82MAP3K20.69094069
83FGFR10.69015781
84NEK10.68754528
85MYLK0.67652000
86NTRK20.67449534
87PRKD10.66361287
88PRKCH0.66128958
89WNK40.65869130
90FES0.64263266
91CDC42BPA0.61973642
92MAP2K10.61583040
93PAK40.61154625
94GRK60.60222036
95NME10.59500579
96CDK80.58485450
97RPS6KB20.58265149
98MAP3K80.58080489
99BRSK10.57441602
100TNK20.57351784
101FLT30.56517146
102MOS0.55559169
103AKT20.54830727
104CDK60.53516500
105TAOK20.52535119
106CDK140.52073927
107ROCK10.51303427
108MARK10.51302030
109PDK10.50991004
110CDK150.50876906
111DAPK20.48921915
112ERN10.48295766
113PRKG20.47950333
114RAF10.47757210
115MAP3K10.47339233
116STK380.47070520
117TTK0.46800153
118ILK0.46447717
119MAP3K30.45469773
120BRD40.45437482
121PRKD20.44883723
122CDK11A0.44109389
123TRPM70.43922341
124CDK90.42992873
125SRC0.42732292
126PRKAA20.42480329
127SGK30.42221786
128MAPK100.42044873
129MELK0.41792352
130RPS6KA30.41549393
131KSR10.40863127
132CDK180.39723081
133MAP2K30.39661009
134TGFBR20.39583198
135PIK3CA0.38757393
136RPS6KB10.38639381
137TSSK60.38488448
138BRAF0.38457049
139CSNK1D0.38152989
140AKT30.35709746
141MAPKAPK50.35031102

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.24286806
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17052449
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92856795
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.92333454
5Dilated cardiomyopathy_Homo sapiens_hsa054141.86381341
6Complement and coagulation cascades_Homo sapiens_hsa046101.85091781
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78036827
8Long-term potentiation_Homo sapiens_hsa047201.74154726
9Gastric acid secretion_Homo sapiens_hsa049711.71299134
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70282153
11Salivary secretion_Homo sapiens_hsa049701.67822459
12Biosynthesis of amino acids_Homo sapiens_hsa012301.62799685
13Prion diseases_Homo sapiens_hsa050201.60742383
14Nicotine addiction_Homo sapiens_hsa050331.59527061
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56558786
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56492395
17Estrogen signaling pathway_Homo sapiens_hsa049151.53376811
18Pentose phosphate pathway_Homo sapiens_hsa000301.51735245
19Cardiac muscle contraction_Homo sapiens_hsa042601.50835609
20N-Glycan biosynthesis_Homo sapiens_hsa005101.50690721
21Adherens junction_Homo sapiens_hsa045201.49162632
22Oxytocin signaling pathway_Homo sapiens_hsa049211.44126406
23Thyroid cancer_Homo sapiens_hsa052161.43750836
24GABAergic synapse_Homo sapiens_hsa047271.43091861
25Glutamatergic synapse_Homo sapiens_hsa047241.41717791
26Pancreatic secretion_Homo sapiens_hsa049721.39620011
27Renin secretion_Homo sapiens_hsa049241.39560609
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39155812
29Gap junction_Homo sapiens_hsa045401.37392899
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36489890
31Long-term depression_Homo sapiens_hsa047301.35489368
32Fructose and mannose metabolism_Homo sapiens_hsa000511.34429279
33Galactose metabolism_Homo sapiens_hsa000521.33480397
34Dopaminergic synapse_Homo sapiens_hsa047281.32066701
35Amphetamine addiction_Homo sapiens_hsa050311.31192714
36Glioma_Homo sapiens_hsa052141.30826857
37Circadian entrainment_Homo sapiens_hsa047131.30770574
38Nitrogen metabolism_Homo sapiens_hsa009101.30081102
39ECM-receptor interaction_Homo sapiens_hsa045121.29431102
40Synaptic vesicle cycle_Homo sapiens_hsa047211.29148102
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28857816
42GnRH signaling pathway_Homo sapiens_hsa049121.28074662
43Arginine biosynthesis_Homo sapiens_hsa002201.27069321
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26668532
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22252977
46mTOR signaling pathway_Homo sapiens_hsa041501.22082923
47Focal adhesion_Homo sapiens_hsa045101.21931170
48Insulin secretion_Homo sapiens_hsa049111.19645623
49Cholinergic synapse_Homo sapiens_hsa047251.19604898
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19585557
51VEGF signaling pathway_Homo sapiens_hsa043701.19527654
52Vitamin B6 metabolism_Homo sapiens_hsa007501.17883315
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17289598
54Type II diabetes mellitus_Homo sapiens_hsa049301.15515977
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14324623
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13466195
57Cocaine addiction_Homo sapiens_hsa050301.12929762
58Vibrio cholerae infection_Homo sapiens_hsa051101.12212740
59Fatty acid biosynthesis_Homo sapiens_hsa000611.12085941
60Dorso-ventral axis formation_Homo sapiens_hsa043201.11765889
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.10163952
62Renal cell carcinoma_Homo sapiens_hsa052111.07469039
63Morphine addiction_Homo sapiens_hsa050321.06185693
64Pancreatic cancer_Homo sapiens_hsa052121.04903468
65Glucagon signaling pathway_Homo sapiens_hsa049221.03647578
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02932172
67Protein digestion and absorption_Homo sapiens_hsa049741.02907665
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01880679
69Calcium signaling pathway_Homo sapiens_hsa040201.01721817
70Bladder cancer_Homo sapiens_hsa052191.00435934
71Taste transduction_Homo sapiens_hsa047420.97557873
72AMPK signaling pathway_Homo sapiens_hsa041520.97534123
73ErbB signaling pathway_Homo sapiens_hsa040120.96458210
74Olfactory transduction_Homo sapiens_hsa047400.96004542
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95340024
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.94969518
77MicroRNAs in cancer_Homo sapiens_hsa052060.92568720
78Axon guidance_Homo sapiens_hsa043600.91887177
79Non-small cell lung cancer_Homo sapiens_hsa052230.91793890
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91223973
81Proteoglycans in cancer_Homo sapiens_hsa052050.91157266
82Tight junction_Homo sapiens_hsa045300.89077189
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88584356
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88542987
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.88290041
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88059007
87Thyroid hormone synthesis_Homo sapiens_hsa049180.87612901
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87509457
89Chronic myeloid leukemia_Homo sapiens_hsa052200.87298867
90Melanogenesis_Homo sapiens_hsa049160.86875093
91Bile secretion_Homo sapiens_hsa049760.86802190
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.86212173
93Steroid biosynthesis_Homo sapiens_hsa001000.85804844
94Insulin signaling pathway_Homo sapiens_hsa049100.85803807
95Amoebiasis_Homo sapiens_hsa051460.85264919
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85254756
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84881427
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.84520823
99cAMP signaling pathway_Homo sapiens_hsa040240.83083611
100Serotonergic synapse_Homo sapiens_hsa047260.79193380
101Phenylalanine metabolism_Homo sapiens_hsa003600.78610604
102Arginine and proline metabolism_Homo sapiens_hsa003300.77793047
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77532985
104Hippo signaling pathway_Homo sapiens_hsa043900.76897989
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74713519
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73364769
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.73124734
108Platelet activation_Homo sapiens_hsa046110.73119216
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72627997
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72294549
111Fatty acid metabolism_Homo sapiens_hsa012120.72025346
112Prostate cancer_Homo sapiens_hsa052150.71939476
113Insulin resistance_Homo sapiens_hsa049310.71813330
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71383944
115Choline metabolism in cancer_Homo sapiens_hsa052310.70794988
116Fat digestion and absorption_Homo sapiens_hsa049750.69833934
117Lysine degradation_Homo sapiens_hsa003100.68600883
118PPAR signaling pathway_Homo sapiens_hsa033200.67748738
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67217483
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66871330
121Lysosome_Homo sapiens_hsa041420.66291102
122MAPK signaling pathway_Homo sapiens_hsa040100.65467583
123HIF-1 signaling pathway_Homo sapiens_hsa040660.65442170
124Rap1 signaling pathway_Homo sapiens_hsa040150.64256468
125Notch signaling pathway_Homo sapiens_hsa043300.62257362
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62214730
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61411723
128Acute myeloid leukemia_Homo sapiens_hsa052210.61135145
129Inositol phosphate metabolism_Homo sapiens_hsa005620.60969380
130Small cell lung cancer_Homo sapiens_hsa052220.58703910
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57550935
132Starch and sucrose metabolism_Homo sapiens_hsa005000.57272647
133Carbon metabolism_Homo sapiens_hsa012000.57255870
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56672942
135Endocytosis_Homo sapiens_hsa041440.56486443
136Sphingolipid metabolism_Homo sapiens_hsa006000.55848260
137Endometrial cancer_Homo sapiens_hsa052130.55726395
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.54632438
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54232202
140Renin-angiotensin system_Homo sapiens_hsa046140.52294581
141Melanoma_Homo sapiens_hsa052180.44939699
142Wnt signaling pathway_Homo sapiens_hsa043100.42395443

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