NOMO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.59170691
2Golgi transport vesicle coating (GO:0048200)5.59170691
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.39466831
4skin morphogenesis (GO:0043589)4.26464154
5protein retention in ER lumen (GO:0006621)4.21804478
6basement membrane organization (GO:0071711)4.10349951
7cell adhesion mediated by integrin (GO:0033627)3.96674797
8adherens junction assembly (GO:0034333)3.87356459
9cell-substrate adherens junction assembly (GO:0007045)3.83132572
10focal adhesion assembly (GO:0048041)3.83132572
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.79575558
12protein localization to endosome (GO:0036010)3.63709091
13insulin-like growth factor receptor signaling pathway (GO:0048009)3.54345320
14cell-substrate junction assembly (GO:0007044)3.53037683
15negative regulation of fatty acid transport (GO:2000192)3.37059435
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.35713997
17COPII vesicle coating (GO:0048208)3.32571641
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.27246702
19positive regulation of nuclease activity (GO:0032075)3.21111429
20negative regulation of fibrinolysis (GO:0051918)3.14663182
21epithelial cell-cell adhesion (GO:0090136)3.14350146
22proline biosynthetic process (GO:0006561)3.09107221
23vesicle coating (GO:0006901)3.07095499
24endoplasmic reticulum unfolded protein response (GO:0030968)3.02085771
25regulation of cholesterol homeostasis (GO:2000188)3.01196064
26stress fiber assembly (GO:0043149)3.00819977
27peptidyl-proline hydroxylation (GO:0019511)2.96013301
28ER-nucleus signaling pathway (GO:0006984)2.93762194
29protein hydroxylation (GO:0018126)2.90222892
30membrane protein ectodomain proteolysis (GO:0006509)2.88907319
31endocardial cushion development (GO:0003197)2.88060293
32endodermal cell differentiation (GO:0035987)2.87840351
33regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85048088
34pinocytosis (GO:0006907)2.84741446
35apoptotic cell clearance (GO:0043277)2.84222080
36regulation of nuclease activity (GO:0032069)2.81875726
37regulation of glucose import in response to insulin stimulus (GO:2001273)2.79481040
38cellular response to unfolded protein (GO:0034620)2.78796094
39negative regulation of cell size (GO:0045792)2.76085907
40activation of Rac GTPase activity (GO:0032863)2.75965060
41branching involved in mammary gland duct morphogenesis (GO:0060444)2.75232058
42embryonic process involved in female pregnancy (GO:0060136)2.74613370
43hypotonic response (GO:0006971)2.74235263
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70405544
45semaphorin-plexin signaling pathway (GO:0071526)2.69548246
46mannose metabolic process (GO:0006013)2.68167590
47nuclear pore complex assembly (GO:0051292)2.65838402
48mesodermal cell differentiation (GO:0048333)2.65736026
49regulation of cardioblast differentiation (GO:0051890)2.57903624
50regulation of early endosome to late endosome transport (GO:2000641)2.57850091
51positive regulation of receptor recycling (GO:0001921)2.54494355
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54251455
53peptidyl-glutamic acid carboxylation (GO:0017187)2.54189906
54protein carboxylation (GO:0018214)2.54189906
55planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54183574
56cellular response to topologically incorrect protein (GO:0035967)2.52491644
57positive regulation of endothelial cell apoptotic process (GO:2000353)2.52113939
58desmosome organization (GO:0002934)2.51555529
59maternal placenta development (GO:0001893)2.50467090
60regulation of fibrinolysis (GO:0051917)2.49822570
61regulation of NFAT protein import into nucleus (GO:0051532)2.49377572
62glucose 6-phosphate metabolic process (GO:0051156)2.47357183
63atrioventricular valve morphogenesis (GO:0003181)2.47028483
64cortical actin cytoskeleton organization (GO:0030866)2.43478547
65response to endoplasmic reticulum stress (GO:0034976)2.42891388
66cellular response to epidermal growth factor stimulus (GO:0071364)2.42050144
67mammary gland epithelial cell proliferation (GO:0033598)2.41835021
68regulation of plasminogen activation (GO:0010755)2.41245965
69substrate-dependent cell migration (GO:0006929)2.39667799
70positive regulation of osteoblast proliferation (GO:0033690)2.39364195
71regulation of nucleobase-containing compound transport (GO:0032239)2.38668949
72glucocorticoid receptor signaling pathway (GO:0042921)2.38343345
73dicarboxylic acid biosynthetic process (GO:0043650)2.38008669
74platelet degranulation (GO:0002576)2.37719014
75barbed-end actin filament capping (GO:0051016)2.37213703
76embryonic camera-type eye morphogenesis (GO:0048596)2.36877655
77hyaluronan catabolic process (GO:0030214)2.36183828
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35665833
79regulation of translational fidelity (GO:0006450)2.35177458
80cellular copper ion homeostasis (GO:0006878)2.35135686
81regulation of extracellular matrix disassembly (GO:0010715)2.34903688
824-hydroxyproline metabolic process (GO:0019471)2.34250793
83cellular response to prostaglandin stimulus (GO:0071379)2.32989249
84vascular endothelial growth factor signaling pathway (GO:0038084)2.31447229
85peptidyl-asparagine modification (GO:0018196)2.30489015
86chondrocyte proliferation (GO:0035988)2.30181647
87protein N-linked glycosylation via asparagine (GO:0018279)2.29767292
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29053612
89protein maturation by protein folding (GO:0022417)2.28887308
90glomerular basement membrane development (GO:0032836)2.28619928
91positive regulation of extracellular matrix organization (GO:1903055)2.28510370
92gap junction assembly (GO:0016264)2.27521957
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25544633
94embryonic eye morphogenesis (GO:0048048)2.24525543
95bundle of His cell to Purkinje myocyte communication (GO:0086069)2.24048167
96collagen fibril organization (GO:0030199)2.23587299
97protein targeting to plasma membrane (GO:0072661)2.20978865
98regulation of RNA export from nucleus (GO:0046831)2.20429530
99blood vessel endothelial cell migration (GO:0043534)2.20279893
100regulation of apoptotic cell clearance (GO:2000425)2.20248163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78378930
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.97823307
3CLOCK_20551151_ChIP-Seq_293T_Human2.86611113
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74585362
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.61471689
6ZNF263_19887448_ChIP-Seq_K562_Human2.38201357
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36499327
8E2F7_22180533_ChIP-Seq_HELA_Human2.24053471
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.21960795
10RACK7_27058665_Chip-Seq_MCF-7_Human2.21307409
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.13846097
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.11996553
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10526296
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09923440
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06483380
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05536060
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03496606
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94511640
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.92590559
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89508974
21MYC_22102868_ChIP-Seq_BL_Human1.87872117
22P300_27058665_Chip-Seq_ZR-75-30cells_Human1.87255044
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86595200
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85350062
25LXR_22292898_ChIP-Seq_THP-1_Human1.83650892
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77588441
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77213347
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.75685893
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75141437
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73875968
31TCF7_22412390_ChIP-Seq_EML_Mouse1.73531467
32KDM2B_26808549_Chip-Seq_K562_Human1.72025688
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68982249
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67613228
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67021923
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65241444
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64778361
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63471578
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59027620
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58016999
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56705690
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54338162
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52251689
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48222594
45KDM2B_26808549_Chip-Seq_DND41_Human1.46424052
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.46279139
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.45298534
48ATF3_27146783_Chip-Seq_COLON_Human1.42868442
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42656659
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41814344
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40474406
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38987372
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.35049366
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.34506700
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.34506700
56TP53_22127205_ChIP-Seq_IMR90_Human1.33173315
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.33003463
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30753355
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29112246
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28475253
61VDR_21846776_ChIP-Seq_THP-1_Human1.28216338
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28187164
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27361317
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26495971
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.25558894
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.24925106
67AR_21909140_ChIP-Seq_LNCAP_Human1.23962589
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23489091
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22793269
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21587046
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20928077
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20844480
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20091284
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20045547
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19903669
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.17302424
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15657048
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14810912
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13209978
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12817079
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10876538
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10876538
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10333531
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10237756
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09952193
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09236450
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08678778
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08677602
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08335820
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07645016
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.07545387
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06424344
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.05561536
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03820662
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03583737
96CHD1_26751641_Chip-Seq_LNCaP_Human1.02518892
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01939418
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00916229
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00239992
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00000959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.77758500
2MP0003705_abnormal_hypodermis_morpholog4.54303299
3MP0003566_abnormal_cell_adhesion3.62761560
4MP0004272_abnormal_basement_membrane3.29378347
5MP0005451_abnormal_body_composition2.66105635
6MP0002877_abnormal_melanocyte_morpholog2.62865725
7MP0005058_abnormal_lysosome_morphology2.45907781
8MP0005623_abnormal_meninges_morphology2.39423024
9MP0004233_abnormal_muscle_weight2.36397038
10MP0005076_abnormal_cell_differentiation2.31834256
11MP0010352_gastrointestinal_tract_polyps2.16068046
12MP0003091_abnormal_cell_migration2.09677333
13MP0005257_abnormal_intraocular_pressure2.06100419
14MP0010368_abnormal_lymphatic_system1.99895056
15MP0001849_ear_inflammation1.99430704
16MP0009780_abnormal_chondrocyte_physiolo1.97077056
17MP0000751_myopathy1.96856673
18MP0003279_aneurysm1.96400052
19MP0005409_darkened_coat_color1.93951311
20MP0009384_cardiac_valve_regurgitation1.85904556
21MP0003172_abnormal_lysosome_physiology1.83634970
22MP0001958_emphysema1.68165420
23MP0001915_intracranial_hemorrhage1.63934887
24MP0010234_abnormal_vibrissa_follicle1.61749125
25MP0000767_abnormal_smooth_muscle1.56561749
26MP0003941_abnormal_skin_development1.53174888
27MP0009840_abnormal_foam_cell1.51453174
28MP0001348_abnormal_lacrimal_gland1.50790754
29MP0004858_abnormal_nervous_system1.49391008
30MP0003300_gastrointestinal_ulcer1.48230025
31MP0004264_abnormal_extraembryonic_tissu1.45226793
32MP0003329_amyloid_beta_deposits1.43706255
33MP0002060_abnormal_skin_morphology1.39958398
34MP0010630_abnormal_cardiac_muscle1.36824624
35MP0004185_abnormal_adipocyte_glucose1.33006417
36MP0005023_abnormal_wound_healing1.32640887
37MP0000747_muscle_weakness1.31548428
38MP0002896_abnormal_bone_mineralization1.29767378
39MP0004084_abnormal_cardiac_muscle1.29113512
40MP0000534_abnormal_ureter_morphology1.29084562
41MP0000733_abnormal_muscle_development1.28060346
42MP0004087_abnormal_muscle_fiber1.27643007
43MP0000003_abnormal_adipose_tissue1.26417569
44MP0009672_abnormal_birth_weight1.25612220
45MP0002089_abnormal_postnatal_growth/wei1.21580040
46MP0001661_extended_life_span1.21489996
47MP0005275_abnormal_skin_tensile1.19415026
48MP0006138_congestive_heart_failure1.18947782
49MP0003950_abnormal_plasma_membrane1.17812318
50MP0001730_embryonic_growth_arrest1.17727515
51MP0003115_abnormal_respiratory_system1.17442826
52MP0003191_abnormal_cellular_cholesterol1.14335152
53MP0003868_abnormal_feces_composition1.13115264
54MP0005621_abnormal_cell_physiology1.12355735
55MP0008260_abnormal_autophagy1.10870862
56MP0003453_abnormal_keratinocyte_physiol1.08299308
57MP0003942_abnormal_urinary_system1.05829417
58MP0004036_abnormal_muscle_relaxation1.05297632
59MP0002269_muscular_atrophy1.05252698
60MP0005330_cardiomyopathy1.04233680
61MP0000858_altered_metastatic_potential1.03846738
62MP0000759_abnormal_skeletal_muscle1.03185953
63MP0000537_abnormal_urethra_morphology1.02071354
64MP0002086_abnormal_extraembryonic_tissu1.00724146
65MP0005503_abnormal_tendon_morphology1.00151089
66MP0002796_impaired_skin_barrier0.96643287
67MP0003984_embryonic_growth_retardation0.94943541
68MP0003828_pulmonary_edema0.92569310
69MP0002108_abnormal_muscle_morphology0.90755556
70MP0005501_abnormal_skin_physiology0.89262413
71MP0002088_abnormal_embryonic_growth/wei0.89238540
72MP0005375_adipose_tissue_phenotype0.88054828
73MP0002128_abnormal_blood_circulation0.86539482
74MP0002925_abnormal_cardiovascular_devel0.86527059
75MP0001614_abnormal_blood_vessel0.84260002
76MP0001672_abnormal_embryogenesis/_devel0.83705634
77MP0005380_embryogenesis_phenotype0.83705634
78MP0005666_abnormal_adipose_tissue0.82608971
79MP0001666_abnormal_nutrient_absorption0.82192417
80MP0000013_abnormal_adipose_tissue0.81276190
81MP0005408_hypopigmentation0.79789151
82MP0004510_myositis0.79716369
83MP0003634_abnormal_glial_cell0.78334172
84MP0005384_cellular_phenotype0.77886725
85MP0005508_abnormal_skeleton_morphology0.77716829
86MP0002080_prenatal_lethality0.77578768
87MP0004782_abnormal_surfactant_physiolog0.76344557
88MP0000749_muscle_degeneration0.76300082
89MP0005165_increased_susceptibility_to0.75272172
90MP0001299_abnormal_eye_distance/0.74864150
91MP0003385_abnormal_body_wall0.74590404
92MP0000627_abnormal_mammary_gland0.73751167
93MP0002295_abnormal_pulmonary_circulatio0.72164730
94MP0000462_abnormal_digestive_system0.71228920
95MP0000428_abnormal_craniofacial_morphol0.68962707
96MP0009053_abnormal_anal_canal0.68884666
97MP0004808_abnormal_hematopoietic_stem0.67714910
98MP0003221_abnormal_cardiomyocyte_apopto0.64738673
99MP0006054_spinal_hemorrhage0.64109313
100MP0000762_abnormal_tongue_morphology0.63041188

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.86185643
2Premature rupture of membranes (HP:0001788)4.64361417
3Deep venous thrombosis (HP:0002625)3.54170920
4Cerebral aneurysm (HP:0004944)3.26039796
5Arterial tortuosity (HP:0005116)3.10236306
6Vertebral compression fractures (HP:0002953)2.99923047
7Vascular tortuosity (HP:0004948)2.96228197
8Asymmetry of the thorax (HP:0001555)2.70908950
9Abnormality of dentin (HP:0010299)2.65237923
10Hyperacusis (HP:0010780)2.62921404
11Cervical subluxation (HP:0003308)2.61718459
12Spinal rigidity (HP:0003306)2.61602779
13Ulnar bowing (HP:0003031)2.58513480
14Ankle contracture (HP:0006466)2.55462488
15Aortic dissection (HP:0002647)2.52978188
16Wormian bones (HP:0002645)2.52507858
17Abnormality of the Achilles tendon (HP:0005109)2.51714030
18Flat acetabular roof (HP:0003180)2.51412608
19Achilles tendon contracture (HP:0001771)2.50912997
20Distal lower limb amyotrophy (HP:0008944)2.46632762
21Mitral stenosis (HP:0001718)2.42393063
22Back pain (HP:0003418)2.41027946
23Aneurysm (HP:0002617)2.39386040
24Shallow orbits (HP:0000586)2.34548413
25Upper limb amyotrophy (HP:0009129)2.32853729
26Distal upper limb amyotrophy (HP:0007149)2.32853729
27Increased variability in muscle fiber diameter (HP:0003557)2.31688341
28Broad face (HP:0000283)2.30565535
29Aortic aneurysm (HP:0004942)2.29462378
30Mildly elevated creatine phosphokinase (HP:0008180)2.29330381
31Mitral valve prolapse (HP:0001634)2.27315409
32Short nail (HP:0001799)2.20967266
33Increased connective tissue (HP:0009025)2.20947552
34Blue sclerae (HP:0000592)2.17593748
35Abnormality of skeletal muscle fiber size (HP:0012084)2.16608558
36Fragile skin (HP:0001030)2.15295871
37Abnormality of the acetabulum (HP:0003170)2.14260913
38Menorrhagia (HP:0000132)2.13953535
39J-shaped sella turcica (HP:0002680)2.13143462
40Type 1 muscle fiber predominance (HP:0003803)2.11529945
41Disproportionate tall stature (HP:0001519)2.10041657
42Biconcave vertebral bodies (HP:0004586)2.08980428
43Bladder diverticulum (HP:0000015)2.07895518
44Cardiovascular calcification (HP:0011915)2.05899228
45Distal lower limb muscle weakness (HP:0009053)2.05453228
46Ankyloglossia (HP:0010296)1.99048446
47Centrally nucleated skeletal muscle fibers (HP:0003687)1.97468133
48Mitral regurgitation (HP:0001653)1.96824513
49Osteolytic defects of the hand bones (HP:0009699)1.94824511
50Osteolytic defects of the phalanges of the hand (HP:0009771)1.94824511
51Abnormal ossification of hand bones (HP:0005921)1.91618517
52Joint laxity (HP:0001388)1.89904532
53Abnormality of carpal bone ossification (HP:0006257)1.89445358
54Abnormality of oral frenula (HP:0000190)1.89425741
55Dilatation of the ascending aorta (HP:0005111)1.88683763
56Vascular calcification (HP:0004934)1.87560743
57Coxa vara (HP:0002812)1.87559519
58Right ventricular cardiomyopathy (HP:0011663)1.87150738
59Urinary glycosaminoglycan excretion (HP:0003541)1.84585881
60Mucopolysacchariduria (HP:0008155)1.84585881
61Spondylolisthesis (HP:0003302)1.83406522
62Lower limb amyotrophy (HP:0007210)1.83347114
63Cerebral inclusion bodies (HP:0100314)1.82469621
64Abnormal delivery (HP:0001787)1.81737968
65Hand muscle atrophy (HP:0009130)1.81483132
66Hemorrhage of the eye (HP:0011885)1.79586662
67Genu recurvatum (HP:0002816)1.78660394
68Termporal pattern (HP:0011008)1.78295707
69Insidious onset (HP:0003587)1.78295707
70Atrophic scars (HP:0001075)1.77792900
71Abnormality of the common coagulation pathway (HP:0010990)1.77657829
72Hyperextensible skin (HP:0000974)1.76716668
73Myocardial infarction (HP:0001658)1.76595404
74Syringomyelia (HP:0003396)1.74794175
75Spinal cord lesions (HP:0100561)1.74794175
76Generalized amyotrophy (HP:0003700)1.73221917
77Insomnia (HP:0100785)1.72105126
78Elbow flexion contracture (HP:0002987)1.70583125
79Increased mean platelet volume (HP:0011877)1.70065082
80Obstructive sleep apnea (HP:0002870)1.70053481
81Thin bony cortex (HP:0002753)1.68633610
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.68447793
83Difficulty climbing stairs (HP:0003551)1.68013653
84Soft skin (HP:0000977)1.67806975
85Asymmetric septal hypertrophy (HP:0001670)1.67756140
86Skin nodule (HP:0200036)1.67320676
87Cupped ribs (HP:0000887)1.65161080
88Premature skin wrinkling (HP:0100678)1.63672069
89Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62239155
90Abnormality of polysaccharide metabolism (HP:0011012)1.62239155
91Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62239155
92Neonatal short-limb short stature (HP:0008921)1.62046098
93Dysostosis multiplex (HP:0000943)1.61280043
94Deformed sella turcica (HP:0002681)1.59257018
95Vertebral arch anomaly (HP:0008438)1.59231612
96Dislocated radial head (HP:0003083)1.59078643
97Esophageal varix (HP:0002040)1.57466545
98Advanced eruption of teeth (HP:0006288)1.57019320
99Absent frontal sinuses (HP:0002688)1.56988869
100Slender build (HP:0001533)1.56765967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.08266785
2CDK123.35256059
3ICK3.27450981
4EEF2K3.07491600
5SMG12.78122143
6TTN2.70663868
7PKN22.67081493
8PDGFRA2.62888417
9FGFR42.51787864
10SIK12.47853226
11SCYL22.43307237
12RIPK12.30746030
13ERN12.23161611
14IRAK32.11235652
15EPHA22.05615609
16PRPF4B1.99875304
17LATS21.87593462
18NTRK11.75226424
19PTK21.67358260
20PAK41.51213292
21KSR21.46882888
22MTOR1.35003943
23LATS11.31326875
24LMTK21.29255664
25MAP3K91.28040877
26CAMK1G1.21318944
27BRD41.18317582
28MAP2K31.14964214
29MAP3K131.13913721
30MET1.13456373
31MST1R1.12253725
32FGFR31.08621322
33RET0.99007486
34NEK90.97441903
35PAK20.96414532
36STK380.95192357
37PDPK10.94951029
38DDR20.94420859
39CAMK1D0.89313020
40EPHB10.89154547
41MYLK0.88955262
42TRPM70.88892999
43MAPKAPK30.86341377
44RPS6KB20.85593113
45TESK10.84135014
46PTK60.83116957
47PDGFRB0.82667151
48RPS6KA20.79746058
49SGK30.77272961
50MAP3K30.76923947
51WNK10.76014211
52CDC42BPA0.73285565
53CDK60.68299300
54PRKD30.67650963
55TYRO30.64534314
56PRKD20.64491535
57MELK0.64451942
58CDK70.64358759
59TAOK20.63129033
60MAP3K100.62729653
61MAP3K10.60680709
62MAP3K60.59781933
63DMPK0.59555094
64MAPK110.58385515
65KSR10.55884215
66MARK20.55659951
67EIF2AK10.55284049
68AKT30.54933372
69PDK10.53077327
70MAP2K10.51266974
71CDK90.50397019
72MAP3K20.48045175
73CDK40.47211884
74PIK3CA0.45089593
75ROCK20.44916090
76MOS0.44384443
77ARAF0.43264934
78MAP3K70.42132073
79FLT30.41389006
80RPS6KB10.39705266
81NEK60.38596800
82CDK80.38107838
83PAK60.37544835
84MAP3K140.37040545
85TGFBR20.37029381
86MAP3K80.36869993
87AKT20.36835117
88FGFR10.36580874
89ILK0.35322678
90MAP2K20.33533073
91MAPK100.33005844
92PRKG20.32355232
93PNCK0.31649604
94ERBB40.30977801
95PIK3CG0.30489961
96BMX0.29325844
97ALK0.28316651
98ZAP700.28209794
99RPS6KC10.27322300
100RPS6KL10.27322300

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.23954550
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.19900945
3ECM-receptor interaction_Homo sapiens_hsa045122.01783533
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.96322300
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90313400
6Chronic myeloid leukemia_Homo sapiens_hsa052201.83894806
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80459425
8Central carbon metabolism in cancer_Homo sapiens_hsa052301.80106647
9Focal adhesion_Homo sapiens_hsa045101.79181844
10Non-small cell lung cancer_Homo sapiens_hsa052231.64332084
11Thyroid cancer_Homo sapiens_hsa052161.63673449
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62137266
13Endometrial cancer_Homo sapiens_hsa052131.60839972
14Bladder cancer_Homo sapiens_hsa052191.59553892
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56420805
16N-Glycan biosynthesis_Homo sapiens_hsa005101.53481277
17Proteoglycans in cancer_Homo sapiens_hsa052051.49999017
18Adherens junction_Homo sapiens_hsa045201.45018744
19Glioma_Homo sapiens_hsa052141.43586113
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39835533
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38969337
22Pancreatic cancer_Homo sapiens_hsa052121.38940292
23Dilated cardiomyopathy_Homo sapiens_hsa054141.36520414
24Small cell lung cancer_Homo sapiens_hsa052221.35225826
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30340786
26Prion diseases_Homo sapiens_hsa050201.28573485
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28087948
28Acute myeloid leukemia_Homo sapiens_hsa052211.27846445
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23625464
30Renal cell carcinoma_Homo sapiens_hsa052111.22712343
31Amoebiasis_Homo sapiens_hsa051461.21583927
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18918269
33Complement and coagulation cascades_Homo sapiens_hsa046101.18460512
34Insulin signaling pathway_Homo sapiens_hsa049101.17782557
35VEGF signaling pathway_Homo sapiens_hsa043701.16205798
36Pentose phosphate pathway_Homo sapiens_hsa000301.15103168
37mTOR signaling pathway_Homo sapiens_hsa041501.14268919
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14265085
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12218046
40Lysine degradation_Homo sapiens_hsa003101.11291664
41ErbB signaling pathway_Homo sapiens_hsa040121.10813650
42MicroRNAs in cancer_Homo sapiens_hsa052061.09449127
43Prostate cancer_Homo sapiens_hsa052151.09023837
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.05432926
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04565956
46Estrogen signaling pathway_Homo sapiens_hsa049151.03290759
47AMPK signaling pathway_Homo sapiens_hsa041521.01078981
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99443333
49Vibrio cholerae infection_Homo sapiens_hsa051100.98420854
50Galactose metabolism_Homo sapiens_hsa000520.95474187
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93372474
52Fructose and mannose metabolism_Homo sapiens_hsa000510.93157668
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92251086
54Insulin resistance_Homo sapiens_hsa049310.91440965
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.88159341
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86664698
57Biosynthesis of amino acids_Homo sapiens_hsa012300.86544204
58Choline metabolism in cancer_Homo sapiens_hsa052310.85959161
59Inositol phosphate metabolism_Homo sapiens_hsa005620.85247433
60Notch signaling pathway_Homo sapiens_hsa043300.84786818
61Lysosome_Homo sapiens_hsa041420.82754141
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.80879963
63Thyroid hormone synthesis_Homo sapiens_hsa049180.80600680
64Prolactin signaling pathway_Homo sapiens_hsa049170.80505952
65GnRH signaling pathway_Homo sapiens_hsa049120.79277665
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77742514
67Glucagon signaling pathway_Homo sapiens_hsa049220.77154759
68Long-term potentiation_Homo sapiens_hsa047200.76102754
69Tight junction_Homo sapiens_hsa045300.75715007
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74624950
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74227496
72HIF-1 signaling pathway_Homo sapiens_hsa040660.74114237
73Colorectal cancer_Homo sapiens_hsa052100.70971312
74Protein digestion and absorption_Homo sapiens_hsa049740.70946089
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.69997364
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69851089
77Vitamin B6 metabolism_Homo sapiens_hsa007500.67481091
78Melanoma_Homo sapiens_hsa052180.67333854
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.66357828
80Hippo signaling pathway_Homo sapiens_hsa043900.64426814
81Platelet activation_Homo sapiens_hsa046110.63791472
82Carbon metabolism_Homo sapiens_hsa012000.63747556
83Endocytosis_Homo sapiens_hsa041440.62552837
84Sphingolipid metabolism_Homo sapiens_hsa006000.60475154
85Hepatitis C_Homo sapiens_hsa051600.59730825
86Gap junction_Homo sapiens_hsa045400.59203111
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58918142
88Bile secretion_Homo sapiens_hsa049760.57742226
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57538419
90Rap1 signaling pathway_Homo sapiens_hsa040150.56603117
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54770431
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53949314
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.53287861
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52956334
95Melanogenesis_Homo sapiens_hsa049160.52096666
96Hepatitis B_Homo sapiens_hsa051610.52086612
97Pathways in cancer_Homo sapiens_hsa052000.52026899
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49543292
99FoxO signaling pathway_Homo sapiens_hsa040680.48952212
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48516035

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