NONO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.89907639
2establishment of integrated proviral latency (GO:0075713)4.92322949
3protein localization to kinetochore (GO:0034501)4.56683686
4DNA strand elongation involved in DNA replication (GO:0006271)4.42453893
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23282358
6DNA strand elongation (GO:0022616)4.20622714
7nuclear pore organization (GO:0006999)4.19695791
8nuclear pore complex assembly (GO:0051292)4.06570147
9DNA replication initiation (GO:0006270)3.99188174
10mitotic chromosome condensation (GO:0007076)3.97465012
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.93027620
12sister chromatid segregation (GO:0000819)3.92727466
13telomere maintenance via semi-conservative replication (GO:0032201)3.86177543
14mitotic sister chromatid cohesion (GO:0007064)3.84505373
15heterochromatin organization (GO:0070828)3.79150014
16mitotic nuclear envelope disassembly (GO:0007077)3.79078206
17negative regulation of RNA splicing (GO:0033119)3.75762324
18protein localization to chromosome, centromeric region (GO:0071459)3.72805497
19DNA ligation (GO:0006266)3.69912167
20establishment of viral latency (GO:0019043)3.68818265
21mitotic recombination (GO:0006312)3.68787703
22mitotic sister chromatid segregation (GO:0000070)3.66729022
23DNA duplex unwinding (GO:0032508)3.62430791
24DNA geometric change (GO:0032392)3.60414909
25DNA topological change (GO:0006265)3.53641800
26membrane disassembly (GO:0030397)3.53383383
27nuclear envelope disassembly (GO:0051081)3.53383383
28double-strand break repair via nonhomologous end joining (GO:0006303)3.52924479
29non-recombinational repair (GO:0000726)3.52924479
30DNA replication-dependent nucleosome organization (GO:0034723)3.52830390
31DNA replication-dependent nucleosome assembly (GO:0006335)3.52830390
32telomere maintenance via recombination (GO:0000722)3.51822412
33dosage compensation (GO:0007549)3.50754216
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49502762
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.46708769
36mitotic metaphase plate congression (GO:0007080)3.42565917
37kinetochore organization (GO:0051383)3.41601114
38IMP biosynthetic process (GO:0006188)3.40870106
39formation of translation preinitiation complex (GO:0001731)3.39612801
40ribosomal small subunit assembly (GO:0000028)3.38755500
41protein complex localization (GO:0031503)3.31453031
42DNA replication checkpoint (GO:0000076)3.28315768
43translesion synthesis (GO:0019985)3.27839070
44folic acid-containing compound biosynthetic process (GO:0009396)3.27838551
45negative regulation of mRNA processing (GO:0050686)3.27798915
46regulation of spindle organization (GO:0090224)3.26993101
47L-serine metabolic process (GO:0006563)3.26396577
48nucleobase biosynthetic process (GO:0046112)3.26122082
49regulation of sister chromatid cohesion (GO:0007063)3.20195683
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.19464758
51ribosome assembly (GO:0042255)3.19304807
52DNA replication-independent nucleosome organization (GO:0034724)3.17961551
53DNA replication-independent nucleosome assembly (GO:0006336)3.17961551
54CENP-A containing nucleosome assembly (GO:0034080)3.14604479
55telomere maintenance via telomere lengthening (GO:0010833)3.14158694
56regulation of RNA export from nucleus (GO:0046831)3.13655159
57COPI coating of Golgi vesicle (GO:0048205)3.13588790
58Golgi transport vesicle coating (GO:0048200)3.13588790
59peptidyl-arginine methylation (GO:0018216)3.12496598
60peptidyl-arginine N-methylation (GO:0035246)3.12496598
61metaphase plate congression (GO:0051310)3.12185329
62RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11674486
63mRNA splicing, via spliceosome (GO:0000398)3.11674486
64postreplication repair (GO:0006301)3.10051371
65chromatin remodeling at centromere (GO:0031055)3.09955670
66RNA splicing, via transesterification reactions (GO:0000375)3.07760102
67spindle assembly checkpoint (GO:0071173)3.05630193
68histone arginine methylation (GO:0034969)3.05097622
69ATP-dependent chromatin remodeling (GO:0043044)3.04029696
70pore complex assembly (GO:0046931)3.02925967
71mitotic spindle assembly checkpoint (GO:0007094)3.02077459
72DNA conformation change (GO:0071103)3.01847209
73regulation of chromosome segregation (GO:0051983)3.01597397
74negative regulation of chromosome segregation (GO:0051985)3.01277730
75negative regulation of mitotic sister chromatid separation (GO:2000816)3.00567805
76negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00567805
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00567805
78negative regulation of sister chromatid segregation (GO:0033046)3.00567805
79spindle checkpoint (GO:0031577)2.98515365
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96114748
81RNA stabilization (GO:0043489)2.95060392
82mRNA stabilization (GO:0048255)2.95060392
83establishment of chromosome localization (GO:0051303)2.94673200
84negative regulation of histone methylation (GO:0031061)2.94488494
85V(D)J recombination (GO:0033151)2.94095651
86chromatin assembly or disassembly (GO:0006333)2.92366645
87negative regulation of mRNA metabolic process (GO:1903312)2.91390996
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91133802
89IMP metabolic process (GO:0046040)2.91024201
90paraxial mesoderm development (GO:0048339)2.90241406
91cellular protein complex localization (GO:0034629)2.90121134
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89817198
93regulation of centriole replication (GO:0046599)2.89525398
94mitotic spindle checkpoint (GO:0071174)2.89510500
95pre-miRNA processing (GO:0031054)2.89113378
96mRNA transport (GO:0051028)2.88531272
97attachment of spindle microtubules to kinetochore (GO:0008608)2.87586202
98positive regulation of chromosome segregation (GO:0051984)2.86679288
99regulation of histone H3-K9 methylation (GO:0051570)2.86079185
100protein localization to chromosome (GO:0034502)2.85861336
101alternative mRNA splicing, via spliceosome (GO:0000380)2.85694340
102purine nucleobase biosynthetic process (GO:0009113)2.85500745
103glucocorticoid receptor signaling pathway (GO:0042921)2.85485141
104protein-DNA complex disassembly (GO:0032986)2.84498998
105nucleosome disassembly (GO:0006337)2.84498998
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83040924
107maturation of SSU-rRNA (GO:0030490)2.82345841
108regulation of DNA damage checkpoint (GO:2000001)2.81390880
109nuclear envelope organization (GO:0006998)2.79216380
110kinetochore assembly (GO:0051382)2.78656914
111chromatin assembly (GO:0031497)2.78280754
112base-excision repair (GO:0006284)2.78217943
113chromosome condensation (GO:0030261)2.76066914
114chromosome segregation (GO:0007059)2.74002746
115termination of RNA polymerase II transcription (GO:0006369)2.73290241
116peptidyl-arginine omega-N-methylation (GO:0035247)2.73289287
117regulation of mitotic sister chromatid separation (GO:0010965)2.72372422
118regulation of mitotic sister chromatid segregation (GO:0033047)2.72372422
119regulation of sister chromatid segregation (GO:0033045)2.72372422
120RNA export from nucleus (GO:0006405)2.71858321
121viral mRNA export from host cell nucleus (GO:0046784)2.71741624
122regulation of mitotic spindle organization (GO:0060236)2.71689273
123viral transcription (GO:0019083)2.71116735
124protein export from nucleus (GO:0006611)2.69136662
125regulation of translational fidelity (GO:0006450)2.68499182
126translational termination (GO:0006415)2.68475137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.49850673
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.07540617
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75739806
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.52484656
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40541970
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.34909482
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68364489
8MYC_22102868_ChIP-Seq_BL_Human2.53883998
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49578848
10AR_21909140_ChIP-Seq_LNCAP_Human2.35687136
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30434153
12* XRN2_22483619_ChIP-Seq_HELA_Human2.30004518
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29171770
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.26568102
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20783087
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.17711715
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.17605797
18CIITA_25753668_ChIP-Seq_RAJI_Human2.04753965
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03256250
20E2F7_22180533_ChIP-Seq_HELA_Human10.0618618
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96971493
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92798677
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.91122786
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90612199
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87192821
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85788516
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.81596975
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79125621
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76453199
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73221203
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71103997
32TTF2_22483619_ChIP-Seq_HELA_Human1.69948410
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69068435
34VDR_23849224_ChIP-Seq_CD4+_Human1.68235083
35FOXP3_21729870_ChIP-Seq_TREG_Human1.67483394
36* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67477746
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66509075
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61900599
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59243739
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58964043
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58590421
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57867781
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55150666
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53130121
45DCP1A_22483619_ChIP-Seq_HELA_Human1.52854144
46GABP_19822575_ChIP-Seq_HepG2_Human1.52603370
47ELK1_19687146_ChIP-ChIP_HELA_Human1.50327853
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43454224
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42789626
50KDM5A_27292631_Chip-Seq_BREAST_Human1.42518818
51VDR_21846776_ChIP-Seq_THP-1_Human1.41588199
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40803928
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40447312
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.39754009
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39069711
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31858604
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29352228
58CLOCK_20551151_ChIP-Seq_293T_Human1.28855595
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27364650
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27036632
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26182959
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26041069
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23142344
64ZNF263_19887448_ChIP-Seq_K562_Human1.17558542
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17504930
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16855811
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16371868
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16238163
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.15904601
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.14745583
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14125109
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.13958862
73TFEB_21752829_ChIP-Seq_HELA_Human1.12729668
74* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12351283
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10949697
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10218503
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10134727
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06680432
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03642194
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03117493
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02551567
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01408913
83TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01022291
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00906559
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00874560
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00873603
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99827052
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99111871
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.97026754
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96478780
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96252948
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96035950
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95121680
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94198631
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94009310
96* CHD1_26751641_Chip-Seq_LNCaP_Human0.93652407
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93472942
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92751224
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.92031085
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91990404
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91511207
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90995318
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90995318
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90995318
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89712680
106TCF7_22412390_ChIP-Seq_EML_Mouse0.88984234
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88913764
108UTX_26944678_Chip-Seq_JUKART_Human0.88530120
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86420127
110* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85300475
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.84277388
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83646789
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82903159
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82753622
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81588932
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.81377588
117MAF_26560356_Chip-Seq_TH1_Human0.79527834
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79406754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.68911431
2MP0003693_abnormal_embryo_hatching3.62261909
3MP0003111_abnormal_nucleus_morphology3.38602935
4MP0003077_abnormal_cell_cycle3.25097745
5MP0004957_abnormal_blastocyst_morpholog3.22390794
6MP0010030_abnormal_orbit_morphology3.07704716
7MP0008057_abnormal_DNA_replication2.66685178
8MP0008007_abnormal_cellular_replicative2.61062460
9MP0010352_gastrointestinal_tract_polyps2.53991778
10MP0003123_paternal_imprinting2.53398444
11MP0008932_abnormal_embryonic_tissue2.18868261
12MP0001730_embryonic_growth_arrest2.15782622
13MP0008058_abnormal_DNA_repair2.14734408
14MP0000537_abnormal_urethra_morphology2.11358308
15MP0000350_abnormal_cell_proliferation2.08424510
16MP0003121_genomic_imprinting2.03685752
17MP0005076_abnormal_cell_differentiation2.00370260
18MP0002396_abnormal_hematopoietic_system1.99593007
19MP0009053_abnormal_anal_canal1.94987251
20MP0006054_spinal_hemorrhage1.89857364
21MP0002877_abnormal_melanocyte_morpholog1.80334140
22MP0004808_abnormal_hematopoietic_stem1.75414242
23MP0005380_embryogenesis_phenotype1.75137751
24MP0001672_abnormal_embryogenesis/_devel1.75137751
25MP0001697_abnormal_embryo_size1.72502587
26MP0003705_abnormal_hypodermis_morpholog1.72303362
27MP0004197_abnormal_fetal_growth/weight/1.70871839
28MP0002085_abnormal_embryonic_tissue1.69977527
29* MP0002084_abnormal_developmental_patter1.67621771
30MP0002009_preneoplasia1.66439575
31MP0010307_abnormal_tumor_latency1.66362485
32MP0003984_embryonic_growth_retardation1.63198535
33MP0002088_abnormal_embryonic_growth/wei1.61633318
34MP0003567_abnormal_fetal_cardiomyocyte1.59552482
35MP0002080_prenatal_lethality1.51112997
36MP0003890_abnormal_embryonic-extraembry1.50647620
37MP0001293_anophthalmia1.49585975
38MP0009697_abnormal_copulation1.46322402
39MP0000490_abnormal_crypts_of1.46116979
40MP0000566_synostosis1.45496043
41MP0002086_abnormal_extraembryonic_tissu1.43946289
42MP0000428_abnormal_craniofacial_morphol1.35787790
43MP0002938_white_spotting1.29784297
44MP0003119_abnormal_digestive_system1.29703888
45MP0001346_abnormal_lacrimal_gland1.29613470
46MP0003115_abnormal_respiratory_system1.26613911
47MP0009278_abnormal_bone_marrow1.21947140
48MP0000049_abnormal_middle_ear1.20953482
49MP0003937_abnormal_limbs/digits/tail_de1.20766226
50MP0003221_abnormal_cardiomyocyte_apopto1.18453311
51MP0001849_ear_inflammation1.17877736
52MP0002653_abnormal_ependyma_morphology1.17518495
53MP0003315_abnormal_perineum_morphology1.17286306
54MP0000313_abnormal_cell_death1.16117453
55MP0003122_maternal_imprinting1.14654641
56MP0001299_abnormal_eye_distance/1.13880769
57MP0008789_abnormal_olfactory_epithelium1.12938725
58MP0002092_abnormal_eye_morphology1.12464227
59MP0002019_abnormal_tumor_incidence1.12006931
60MP0000733_abnormal_muscle_development1.11779732
61MP0003935_abnormal_craniofacial_develop1.09950505
62MP0005623_abnormal_meninges_morphology1.09720238
63MP0003942_abnormal_urinary_system1.09441235
64MP0000703_abnormal_thymus_morphology1.09314891
65MP0004272_abnormal_basement_membrane1.08038604
66MP0002282_abnormal_trachea_morphology1.03961755
67MP0000569_abnormal_digit_pigmentation1.03614046
68MP0002932_abnormal_joint_morphology1.02734749
69MP0002111_abnormal_tail_morphology1.01992186
70MP0006292_abnormal_olfactory_placode1.01904546
71MP0002249_abnormal_larynx_morphology0.99417584
72MP0005187_abnormal_penis_morphology0.97235295
73MP0003385_abnormal_body_wall0.96816600
74MP0003786_premature_aging0.95871115
75MP0003763_abnormal_thymus_physiology0.95565080
76MP0001286_abnormal_eye_development0.94675164
77MP0009672_abnormal_birth_weight0.93100819
78MP0003755_abnormal_palate_morphology0.93023482
79MP0005394_taste/olfaction_phenotype0.92894114
80MP0005499_abnormal_olfactory_system0.92894114
81MP0002081_perinatal_lethality0.91986535
82MP0003566_abnormal_cell_adhesion0.90855802
83MP0009703_decreased_birth_body0.90165062
84MP0001915_intracranial_hemorrhage0.89578634
85MP0002697_abnormal_eye_size0.88775660
86MP0000358_abnormal_cell_content/0.88548584
87MP0003938_abnormal_ear_development0.87599331
88MP0005023_abnormal_wound_healing0.87468566
89MP0001545_abnormal_hematopoietic_system0.86451480
90MP0005397_hematopoietic_system_phenotyp0.86451480
91MP0003283_abnormal_digestive_organ0.86273395
92MP0002925_abnormal_cardiovascular_devel0.86068200
93MP0005501_abnormal_skin_physiology0.85326278
94MP0002089_abnormal_postnatal_growth/wei0.84078153
95MP0005257_abnormal_intraocular_pressure0.83872137
96MP0008877_abnormal_DNA_methylation0.83580778
97MP0003718_maternal_effect0.83510231
98MP0000432_abnormal_head_morphology0.83399057
99MP0003861_abnormal_nervous_system0.83339500
100MP0002233_abnormal_nose_morphology0.81793403
101MP0002234_abnormal_pharynx_morphology0.81234805
102MP0002398_abnormal_bone_marrow0.81207924
103MP0004185_abnormal_adipocyte_glucose0.81043427
104MP0005384_cellular_phenotype0.79989696
105MP0000778_abnormal_nervous_system0.79823098
106MP0002116_abnormal_craniofacial_bone0.79407237
107MP0002751_abnormal_autonomic_nervous0.79020457
108MP0009333_abnormal_splenocyte_physiolog0.78505143
109MP0004858_abnormal_nervous_system0.78322390
110MP0001529_abnormal_vocalization0.77647125
111MP0003941_abnormal_skin_development0.77328675
112MP0004233_abnormal_muscle_weight0.76395693
113MP0000579_abnormal_nail_morphology0.76281698
114MP0000534_abnormal_ureter_morphology0.76122357
115MP0005621_abnormal_cell_physiology0.73612330
116MP0005248_abnormal_Harderian_gland0.72707194
117MP0001340_abnormal_eyelid_morphology0.72099302
118MP0002722_abnormal_immune_system0.72044078
119MP0002114_abnormal_axial_skeleton0.70691911
120MP0003943_abnormal_hepatobiliary_system0.67591397
121MP0000477_abnormal_intestine_morphology0.67202933
122MP0004264_abnormal_extraembryonic_tissu0.66375564
123MP0009250_abnormal_appendicular_skeleto0.66230012
124MP0010234_abnormal_vibrissa_follicle0.65488883
125MP0005220_abnormal_exocrine_pancreas0.63488575
126MP0000858_altered_metastatic_potential0.63006459

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.82510621
2Short 4th metacarpal (HP:0010044)3.82510621
3Cortical dysplasia (HP:0002539)3.71562668
4Increased nuchal translucency (HP:0010880)3.44087408
5Colon cancer (HP:0003003)3.28434025
6Selective tooth agenesis (HP:0001592)3.08168418
7Ependymoma (HP:0002888)3.05902685
8Proximal placement of thumb (HP:0009623)2.99653870
9Volvulus (HP:0002580)2.98968702
10Deviation of the thumb (HP:0009603)2.94580198
11Abnormality of the 4th metacarpal (HP:0010012)2.93219804
12Medulloblastoma (HP:0002885)2.91720643
13Renal duplication (HP:0000075)2.79366195
14Reticulocytopenia (HP:0001896)2.71690165
15Abnormal number of incisors (HP:0011064)2.61552638
16Birth length less than 3rd percentile (HP:0003561)2.57765283
17Patellar aplasia (HP:0006443)2.56913245
18Hyperacusis (HP:0010780)2.50962449
19Atresia of the external auditory canal (HP:0000413)2.50365930
20Spastic diplegia (HP:0001264)2.48844734
21Abnormality of the anterior horn cell (HP:0006802)2.47378189
22Degeneration of anterior horn cells (HP:0002398)2.47378189
23Aplasia/Hypoplasia of the patella (HP:0006498)2.43388703
24Nephroblastoma (Wilms tumor) (HP:0002667)2.42600053
25Asymmetry of the thorax (HP:0001555)2.41129047
26Astrocytoma (HP:0009592)2.31712759
27Abnormality of the astrocytes (HP:0100707)2.31712759
28Insomnia (HP:0100785)2.26567863
29Chromsome breakage (HP:0040012)2.25542929
30Embryonal renal neoplasm (HP:0011794)2.22713301
31Cutis marmorata (HP:0000965)2.15212141
32Malignant gastrointestinal tract tumors (HP:0006749)2.14700800
33Gastrointestinal carcinoma (HP:0002672)2.14700800
34Multiple enchondromatosis (HP:0005701)2.12351284
35High anterior hairline (HP:0009890)2.12048687
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11891010
3711 pairs of ribs (HP:0000878)2.11299779
38Microvesicular hepatic steatosis (HP:0001414)2.10489243
39Neoplasm of the pancreas (HP:0002894)2.10128513
40Ectopic kidney (HP:0000086)2.06048209
41Glioma (HP:0009733)2.04525687
42Missing ribs (HP:0000921)2.03157947
43Abnormality of chromosome stability (HP:0003220)2.02758818
44Broad distal phalanx of finger (HP:0009836)2.02609478
45Trigonocephaly (HP:0000243)2.01190955
46Shoulder girdle muscle weakness (HP:0003547)2.01160584
47Skull defect (HP:0001362)1.99929518
48Meckel diverticulum (HP:0002245)1.98175810
49Aplasia/Hypoplasia of the sternum (HP:0006714)1.94920121
50Basal cell carcinoma (HP:0002671)1.94863041
51Optic nerve coloboma (HP:0000588)1.94772284
52Myelodysplasia (HP:0002863)1.93489437
53Abnormality of the ileum (HP:0001549)1.93301295
54Abnormal gallbladder physiology (HP:0012438)1.93280299
55Cholecystitis (HP:0001082)1.93280299
56Aplastic anemia (HP:0001915)1.92348846
57Abnormality of the intervertebral disk (HP:0005108)1.91589167
58Abnormality of glycolysis (HP:0004366)1.91459100
59Protrusio acetabuli (HP:0003179)1.91211294
60Small intestinal stenosis (HP:0012848)1.90276001
61Duodenal stenosis (HP:0100867)1.90276001
62Absent epiphyses (HP:0010577)1.89700923
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89700923
64Oral leukoplakia (HP:0002745)1.89397022
65Renovascular hypertension (HP:0100817)1.88036059
66Skin tags (HP:0010609)1.87471326
67Deep philtrum (HP:0002002)1.87265904
68Obsessive-compulsive behavior (HP:0000722)1.86844151
69Bicuspid aortic valve (HP:0001647)1.86657453
70Abnormal lung lobation (HP:0002101)1.86149715
71Abnormality of the calcaneus (HP:0008364)1.85551830
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85087711
73Preauricular skin tag (HP:0000384)1.85064869
74Rhabdomyosarcoma (HP:0002859)1.84584296
75Generalized hypotonia (HP:0001290)1.84332357
76Abnormality of chromosome segregation (HP:0002916)1.83808480
77High pitched voice (HP:0001620)1.82712520
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.82705514
79Increased density of long bones (HP:0006392)1.82421465
80Agnosia (HP:0010524)1.82367670
81Shallow orbits (HP:0000586)1.81098371
82Thrombocytosis (HP:0001894)1.80792715
83Long eyelashes (HP:0000527)1.80486173
84Urethral obstruction (HP:0000796)1.79526757
85Elfin facies (HP:0004428)1.79503044
86Cutaneous melanoma (HP:0012056)1.78998438
87Abnormality of the carotid arteries (HP:0005344)1.78423548
88Amaurosis fugax (HP:0100576)1.78283709
89Bowel diverticulosis (HP:0005222)1.77447653
90Horseshoe kidney (HP:0000085)1.77253401
91Facial cleft (HP:0002006)1.77017455
92Neoplasm of the oral cavity (HP:0100649)1.76924674
93Hepatoblastoma (HP:0002884)1.75789261
94Absent radius (HP:0003974)1.75374665
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74381188
96Termporal pattern (HP:0011008)1.73848719
97Insidious onset (HP:0003587)1.73848719
98Anal stenosis (HP:0002025)1.73795018
99Ankle contracture (HP:0006466)1.73387019
100Broad alveolar ridges (HP:0000187)1.72181756
101Short 5th finger (HP:0009237)1.72157731
102Ovarian neoplasm (HP:0100615)1.71120804
103Tracheoesophageal fistula (HP:0002575)1.70966487
104Abnormality of cells of the erythroid lineage (HP:0012130)1.70562106
105Overlapping toe (HP:0001845)1.70368867
106Hallux valgus (HP:0001822)1.70207053
107Overriding aorta (HP:0002623)1.69985811
108Ulnar bowing (HP:0003031)1.69815710
109Deviation of the hallux (HP:0010051)1.69623340
110Duplication of thumb phalanx (HP:0009942)1.69611853
111Broad palm (HP:0001169)1.68307096
112Heterotopia (HP:0002282)1.68290002
113Neoplasm of striated muscle (HP:0009728)1.67583032
114Abnormality of the preputium (HP:0100587)1.67257346
115Uterine neoplasm (HP:0010784)1.66917833
116Pelvic girdle muscle weakness (HP:0003749)1.66538881
117Slender long bone (HP:0003100)1.65922245
118Choanal atresia (HP:0000453)1.65811055
119Abnormality of the duodenum (HP:0002246)1.65569042
120Facial hemangioma (HP:0000329)1.65459061
121Aplasia involving forearm bones (HP:0009822)1.65205069
122Absent forearm bone (HP:0003953)1.65205069
123Neoplasm of the colon (HP:0100273)1.64611076
124Long palpebral fissure (HP:0000637)1.64251205
125Embryonal neoplasm (HP:0002898)1.64197584
126Abnormality of the labia minora (HP:0012880)1.63873508
127Glossoptosis (HP:0000162)1.63340374
128Cafe-au-lait spot (HP:0000957)1.63157244
129Broad thumb (HP:0011304)1.62773680
130Leiomyosarcoma (HP:0100243)1.62037332
131Uterine leiomyosarcoma (HP:0002891)1.62037332
132Trismus (HP:0000211)1.60330214
133Pointed chin (HP:0000307)1.58350545
134Broad phalanges of the hand (HP:0009768)1.58100050
135Abnormality of cochlea (HP:0000375)1.57370509
136Radioulnar synostosis (HP:0002974)1.57107272
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.55533974
138Vertebral arch anomaly (HP:0008438)1.54900891
139Hypoplastic pelvis (HP:0008839)1.53694666
140Triphalangeal thumb (HP:0001199)1.52777503
141Aplasia/hypoplasia of the humerus (HP:0006507)1.52706343
142Spina bifida occulta (HP:0003298)1.52527822
143Disproportionate tall stature (HP:0001519)1.52249149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.35272705
2BUB13.89926208
3EEF2K3.27181336
4PASK3.06558112
5WEE12.87901580
6NEK22.79766388
7SMG12.58172885
8MAP3K102.35911541
9NEK12.25536808
10PKN22.20944004
11VRK22.20117545
12TGFBR12.09660944
13CDK122.07885815
14MKNK12.07393993
15RPS6KB22.05600979
16TSSK62.04547035
17SRPK12.01273666
18TRIB31.89778561
19ATR1.76101955
20PBK1.71871948
21ACVR1B1.70319889
22TTK1.69739222
23ICK1.68212782
24BRSK21.63213680
25PAK41.62087839
26DYRK31.54890527
27CDK71.54635048
28AURKB1.53618223
29PLK11.53566603
30TESK21.52718343
31RPS6KA41.50941253
32CDK41.50886722
33TAF11.46665716
34BRD41.43241778
35STK101.42635475
36SCYL21.41424005
37BCR1.39304086
38BRSK11.38108611
39TRIM281.34841978
40PLK31.28149494
41EIF2AK11.25660011
42MAP3K81.21494709
43CDK81.20780869
44PLK41.19548994
45CHEK11.18908509
46LRRK21.15408416
47ERBB31.15337854
48CDK61.11739599
49FGFR11.10938453
50MELK1.08094783
51MKNK21.03017310
52CHEK21.01784698
53FLT31.01427800
54CCNB10.99252466
55LATS20.94704524
56PTK60.92233657
57STK40.91290990
58TESK10.89640529
59PDGFRA0.89475797
60CDK20.86408441
61VRK10.84893315
62ATM0.83996090
63MTOR0.81971523
64AURKA0.80430716
65FGFR40.80036057
66TTN0.77850661
67FGFR30.77380778
68TLK10.73675888
69CSNK1A1L0.72551825
70CDK180.72268981
71ILK0.70845381
72CDK11A0.70777180
73CSNK1G30.70613015
74EIF2AK20.70265183
75ALK0.70153407
76SIK30.69605374
77CDK10.69148839
78STK30.68980257
79CDK150.68625085
80FGFR20.67814031
81EPHA20.67329451
82CDK140.63651443
83PAK20.63329270
84CSNK1G10.62878390
85PIM10.61178378
86MAP4K10.60362614
87LATS10.59840689
88KSR10.58874936
89EPHB20.58614117
90PNCK0.57653296
91CDK90.57495594
92BTK0.57381746
93ERBB40.53377790
94ZAK0.53360479
95NTRK10.51620034
96CSNK1E0.51097545
97MAP2K70.49938336
98AKT20.49828675
99CLK10.49637065
100STK160.49055488
101DYRK1B0.48516849
102EPHA30.47440023
103TYRO30.47223960
104CAMK1G0.46458064
105LIMK10.46161976
106DYRK20.46118485
107EIF2AK30.45480599
108PAK10.45313300
109CSNK2A20.45249856
110ERBB20.44530801
111MAP3K40.41454568
112CSNK1G20.40737021
113NEK90.40391624
114CSNK2A10.39746615
115CSF1R0.38899361
116YES10.38753152
117CDK190.38188975
118MET0.38026040
119KSR20.37202525
120PRKDC0.36422145
121MAPKAPK30.35646388
122UHMK10.35307411
123CDK30.34551406
124CAMK1D0.34483624
125MAPK110.34116149
126NME20.33873333
127BRAF0.33802632
128CHUK0.33731090
129GRK60.32989336
130MAPK140.32664513
131RPS6KL10.31369544
132RPS6KC10.31369544
133AKT10.30762986
134RIPK10.29926623
135MAPK90.29522248
136RPS6KA10.29015096
137KDR0.28329016

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.73501720
2Mismatch repair_Homo sapiens_hsa034303.85164123
3Spliceosome_Homo sapiens_hsa030403.43016058
4Cell cycle_Homo sapiens_hsa041103.13016660
5Base excision repair_Homo sapiens_hsa034103.05554983
6RNA transport_Homo sapiens_hsa030132.92050892
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51166311
8Nucleotide excision repair_Homo sapiens_hsa034202.50263084
9Homologous recombination_Homo sapiens_hsa034402.36290206
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33670454
11One carbon pool by folate_Homo sapiens_hsa006702.29825935
12mRNA surveillance pathway_Homo sapiens_hsa030152.12057435
13Ribosome_Homo sapiens_hsa030102.04995007
14Non-homologous end-joining_Homo sapiens_hsa034501.96257604
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87593612
16RNA degradation_Homo sapiens_hsa030181.75551884
17Fanconi anemia pathway_Homo sapiens_hsa034601.75231518
18RNA polymerase_Homo sapiens_hsa030201.69468633
19Proteasome_Homo sapiens_hsa030501.65037402
20p53 signaling pathway_Homo sapiens_hsa041151.64464721
21Pyrimidine metabolism_Homo sapiens_hsa002401.60449079
22Carbon metabolism_Homo sapiens_hsa012001.58873542
23MicroRNAs in cancer_Homo sapiens_hsa052061.38321937
24Viral carcinogenesis_Homo sapiens_hsa052031.37194026
25Basal cell carcinoma_Homo sapiens_hsa052171.36097830
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34810444
27Notch signaling pathway_Homo sapiens_hsa043301.33004081
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32523504
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.32428495
30Systemic lupus erythematosus_Homo sapiens_hsa053221.31060061
31Colorectal cancer_Homo sapiens_hsa052101.30148482
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27665792
33Chronic myeloid leukemia_Homo sapiens_hsa052201.27521179
34HTLV-I infection_Homo sapiens_hsa051661.26378378
35Basal transcription factors_Homo sapiens_hsa030221.23992419
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22602415
37Epstein-Barr virus infection_Homo sapiens_hsa051691.22185111
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20345351
39Steroid biosynthesis_Homo sapiens_hsa001001.19763470
40Small cell lung cancer_Homo sapiens_hsa052221.19336146
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11864396
42Herpes simplex infection_Homo sapiens_hsa051681.11449349
43Hippo signaling pathway_Homo sapiens_hsa043901.11160373
44Antigen processing and presentation_Homo sapiens_hsa046121.10727961
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05169658
46Oocyte meiosis_Homo sapiens_hsa041141.03494564
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03020394
48Thyroid cancer_Homo sapiens_hsa052161.02260282
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00808861
50Pyruvate metabolism_Homo sapiens_hsa006201.00484346
51Viral myocarditis_Homo sapiens_hsa054160.98083638
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96444842
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95645803
54Adherens junction_Homo sapiens_hsa045200.93895423
55Bladder cancer_Homo sapiens_hsa052190.89173262
56Hedgehog signaling pathway_Homo sapiens_hsa043400.88825263
57Hepatitis B_Homo sapiens_hsa051610.83548015
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82602281
59TGF-beta signaling pathway_Homo sapiens_hsa043500.81569803
60Pancreatic cancer_Homo sapiens_hsa052120.80922425
61Endometrial cancer_Homo sapiens_hsa052130.80804069
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.79357217
63Non-small cell lung cancer_Homo sapiens_hsa052230.77984350
64N-Glycan biosynthesis_Homo sapiens_hsa005100.77935286
65Proteoglycans in cancer_Homo sapiens_hsa052050.76444527
66Fatty acid elongation_Homo sapiens_hsa000620.75149059
67Fructose and mannose metabolism_Homo sapiens_hsa000510.74303284
68Legionellosis_Homo sapiens_hsa051340.74224472
69Primary immunodeficiency_Homo sapiens_hsa053400.72520496
70Vitamin B6 metabolism_Homo sapiens_hsa007500.72068255
71mTOR signaling pathway_Homo sapiens_hsa041500.71781253
72Pathways in cancer_Homo sapiens_hsa052000.70733516
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70222194
74Shigellosis_Homo sapiens_hsa051310.69917869
75Purine metabolism_Homo sapiens_hsa002300.69632405
76Apoptosis_Homo sapiens_hsa042100.68946500
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66672781
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66000782
79Alcoholism_Homo sapiens_hsa050340.63370088
80Selenocompound metabolism_Homo sapiens_hsa004500.63243419
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63009956
82Measles_Homo sapiens_hsa051620.62715574
83Lysine degradation_Homo sapiens_hsa003100.62053430
84Acute myeloid leukemia_Homo sapiens_hsa052210.61650899
85Prostate cancer_Homo sapiens_hsa052150.61193556
86Propanoate metabolism_Homo sapiens_hsa006400.58600348
87Galactose metabolism_Homo sapiens_hsa000520.57984790
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.56158621
89Wnt signaling pathway_Homo sapiens_hsa043100.55876330
90Biosynthesis of amino acids_Homo sapiens_hsa012300.55682230
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52927324
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.48252432
93Focal adhesion_Homo sapiens_hsa045100.48022288
94HIF-1 signaling pathway_Homo sapiens_hsa040660.47970012
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47811497
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46913240
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46661434
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46121984
99Protein export_Homo sapiens_hsa030600.45823975
100Influenza A_Homo sapiens_hsa051640.44777098
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44259099
102AMPK signaling pathway_Homo sapiens_hsa041520.43867006
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.43358405
104Fatty acid metabolism_Homo sapiens_hsa012120.42348256
105FoxO signaling pathway_Homo sapiens_hsa040680.41520927
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41233770
107Melanoma_Homo sapiens_hsa052180.40641210
108T cell receptor signaling pathway_Homo sapiens_hsa046600.40539642
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.40191589
110B cell receptor signaling pathway_Homo sapiens_hsa046620.39289184
111ErbB signaling pathway_Homo sapiens_hsa040120.39130835
112Toxoplasmosis_Homo sapiens_hsa051450.37084810
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36935795
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36830110
115Insulin signaling pathway_Homo sapiens_hsa049100.36235570
116Pentose phosphate pathway_Homo sapiens_hsa000300.36207793
117Tight junction_Homo sapiens_hsa045300.35619521
118Axon guidance_Homo sapiens_hsa043600.34093700
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32582021
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32205258
121Glioma_Homo sapiens_hsa052140.31523949
122Folate biosynthesis_Homo sapiens_hsa007900.30118075
123Melanogenesis_Homo sapiens_hsa049160.29918344
124Leishmaniasis_Homo sapiens_hsa051400.29362725
125Renal cell carcinoma_Homo sapiens_hsa052110.28184416
126Prolactin signaling pathway_Homo sapiens_hsa049170.27005469
127VEGF signaling pathway_Homo sapiens_hsa043700.25697910
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25584867
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25461227
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.24887297
131Hematopoietic cell lineage_Homo sapiens_hsa046400.22977312
132Platelet activation_Homo sapiens_hsa046110.22819249

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