NONOP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.70508078
2germinal center formation (GO:0002467)4.69288193
3response to peptidoglycan (GO:0032494)4.54999657
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.46253131
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.46253131
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.46253131
7modulation by symbiont of host immune response (GO:0052553)4.46253131
8positive regulation by symbiont of host defense response (GO:0052509)4.46253131
9modulation by symbiont of host defense response (GO:0052031)4.46253131
10macrophage activation involved in immune response (GO:0002281)4.18154440
11regulation of gamma-delta T cell activation (GO:0046643)4.13925436
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07435940
13negative regulation of cell killing (GO:0031342)4.07435940
14regulation of B cell receptor signaling pathway (GO:0050855)4.06680279
15negative regulation of interleukin-12 production (GO:0032695)4.03621123
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.94039967
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72392321
18detection of molecule of bacterial origin (GO:0032490)3.63224702
19response to muramyl dipeptide (GO:0032495)3.59185123
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57526353
21antigen processing and presentation of endogenous antigen (GO:0019883)3.57507215
22NIK/NF-kappaB signaling (GO:0038061)3.56170105
23negative regulation of cytokine production involved in immune response (GO:0002719)3.54985080
24regulation of interferon-beta biosynthetic process (GO:0045357)3.53649211
25regulation of gamma-delta T cell differentiation (GO:0045586)3.52025744
26defense response to protozoan (GO:0042832)3.50810436
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50765284
28neutrophil activation involved in immune response (GO:0002283)3.47830640
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45032543
30detection of other organism (GO:0098543)3.41409723
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39909379
32negative regulation of T cell mediated immunity (GO:0002710)3.38054595
33regulation of vitamin D biosynthetic process (GO:0060556)3.37485406
34tolerance induction (GO:0002507)3.36586823
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.35351954
36negative regulation of T-helper cell differentiation (GO:0045623)3.35351954
37response to protozoan (GO:0001562)3.33546936
38cellular extravasation (GO:0045123)3.32289201
39regulation of cytokine secretion involved in immune response (GO:0002739)3.27495465
40B cell receptor signaling pathway (GO:0050853)3.26135922
41negative T cell selection (GO:0043383)3.25725565
42negative thymic T cell selection (GO:0045060)3.24644810
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.24631951
44immunoglobulin mediated immune response (GO:0016064)3.24299231
45detection of external biotic stimulus (GO:0098581)3.22834000
46detection of bacterium (GO:0016045)3.21161202
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20658729
48regulation of T-helper 2 cell differentiation (GO:0045628)3.17496808
49JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.16204397
50response to interleukin-15 (GO:0070672)3.15848893
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13315159
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12857749
53leukocyte aggregation (GO:0070486)3.12438159
54neutrophil activation (GO:0042119)3.08431803
55regulation of germinal center formation (GO:0002634)3.07217404
56granulocyte activation (GO:0036230)3.03688624
57cellular response to type I interferon (GO:0071357)3.01351181
58type I interferon signaling pathway (GO:0060337)3.01351181
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99639961
60regulation of interferon-alpha production (GO:0032647)2.99243545
61response to type I interferon (GO:0034340)2.99178288
62myeloid cell activation involved in immune response (GO:0002275)2.98841556
63positive regulation of B cell differentiation (GO:0045579)2.98478883
64interferon-gamma-mediated signaling pathway (GO:0060333)2.98089503
65negative regulation of production of molecular mediator of immune response (GO:0002701)2.96396587
66regulation of interleukin-2 biosynthetic process (GO:0045076)2.94316341
67regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.94021863
68response to host immune response (GO:0052572)2.93926713
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.93926713
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.93670373
71cellular response to interleukin-15 (GO:0071350)2.93645236
72macrophage activation (GO:0042116)2.92325073
73T cell migration (GO:0072678)2.92057294
74negative regulation of interleukin-1 beta production (GO:0032691)2.91432353
75detection of biotic stimulus (GO:0009595)2.90358097
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89819548
77regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89090774
78microglial cell activation (GO:0001774)2.88202516
79regulation of activation of Janus kinase activity (GO:0010533)2.87544194
80positive regulation of interferon-alpha production (GO:0032727)2.86319501
81regulation of antigen processing and presentation (GO:0002577)2.85011388
82regulation of T-helper 1 cell differentiation (GO:0045625)2.84498267
83interferon-gamma production (GO:0032609)2.84335011
84regulation of alpha-beta T cell proliferation (GO:0046640)2.83723301
85regulation of memory T cell differentiation (GO:0043380)2.83122375
86positive regulation of granulocyte differentiation (GO:0030854)2.82609567
87T-helper 1 type immune response (GO:0042088)2.81945936
88T cell selection (GO:0045058)2.81658945
89negative regulation of leukocyte mediated immunity (GO:0002704)2.81188636
90regulation of T-helper cell differentiation (GO:0045622)2.79457027
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.79259330
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78434706
93regulation of interleukin-6 biosynthetic process (GO:0045408)2.77627225
94T-helper cell differentiation (GO:0042093)2.76171353
95CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.76171353
96negative regulation of adaptive immune response (GO:0002820)2.75853695
97cellular response to ethanol (GO:0071361)2.75386689
98positive T cell selection (GO:0043368)2.74776586
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.74574284
100positive thymic T cell selection (GO:0045059)2.73585778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.46736525
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05614407
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.39067495
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.92445494
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28471651
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24353691
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.18098861
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07544734
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06867609
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06486796
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.05621361
12RUNX_20019798_ChIP-Seq_JUKART_Human2.95836276
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95392902
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93400841
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60596320
16MYB_26560356_Chip-Seq_TH2_Human2.60544996
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55064928
18SCL_19346495_ChIP-Seq_HPC-7_Human2.43070781
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40294740
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31983692
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.30238557
22SPI1_23547873_ChIP-Seq_NB4_Human2.29739975
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26394902
24MAF_26560356_Chip-Seq_TH1_Human2.20184488
25MYC_22102868_ChIP-Seq_BL_Human2.16125016
26MYB_26560356_Chip-Seq_TH1_Human2.11844295
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08567577
28VDR_24763502_ChIP-Seq_THP-1_Human2.08289169
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05132356
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.04868762
31VDR_21846776_ChIP-Seq_THP-1_Human2.03667108
32SPI1_23127762_ChIP-Seq_K562_Human2.00154577
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95751317
34GATA3_27048872_Chip-Seq_THYMUS_Human1.85806299
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.79261072
36UTX_26944678_Chip-Seq_JUKART_Human1.77076633
37VDR_24787735_ChIP-Seq_THP-1_Human1.76647814
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76534646
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75518601
40TCF7_22412390_ChIP-Seq_EML_Mouse1.73900743
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68748923
42GATA3_26560356_Chip-Seq_TH2_Human1.61302865
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58911785
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55591107
45CIITA_25753668_ChIP-Seq_RAJI_Human1.50975427
46GATA1_22025678_ChIP-Seq_K562_Human1.50487530
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46279760
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.45642344
49MAF_26560356_Chip-Seq_TH2_Human1.45520402
50PU_27001747_Chip-Seq_BMDM_Mouse1.43702577
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42447426
52GATA1_19941826_ChIP-Seq_K562_Human1.37329594
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37238700
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35984638
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35472966
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34713023
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29517577
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28394676
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26911865
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25521172
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23597250
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22231823
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20928108
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19112837
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.17918770
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16903263
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16750228
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.15203789
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14126605
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12962460
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12654484
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11416289
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09939975
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09786585
75KDM2B_26808549_Chip-Seq_DND41_Human1.07605093
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05318974
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04345005
78TFEB_21752829_ChIP-Seq_HELA_Human1.02993252
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02949136
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01960222
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00383876
82GATA2_19941826_ChIP-Seq_K562_Human0.99817865
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99341670
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97585237
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97272743
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96716231
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95065470
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93416721
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93235934
90NCOR1_26117541_ChIP-Seq_K562_Human0.92934720
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90432864
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90415855
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88269734
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87169613
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86495813
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83870117
97LXR_22158963_ChIP-Seq_LIVER_Mouse0.82964207
98STAT1_20625510_ChIP-Seq_HELA_Human0.81776016
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.80402517
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.79943419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.31657505
2MP0001835_abnormal_antigen_presentation3.73022491
3MP0003436_decreased_susceptibility_to3.65709821
4MP0003724_increased_susceptibility_to3.46085377
5MP0001800_abnormal_humoral_immune2.89698117
6MP0005000_abnormal_immune_tolerance2.82693485
7MP0005387_immune_system_phenotype2.66164529
8MP0001790_abnormal_immune_system2.66164529
9MP0005671_abnormal_response_to2.60332799
10MP0002419_abnormal_innate_immunity2.54142285
11MP0000685_abnormal_immune_system2.52474105
12MP0009785_altered_susceptibility_to2.51671608
13MP0002723_abnormal_immune_serum2.47993384
14MP0002452_abnormal_antigen_presenting2.47413229
15MP0002148_abnormal_hypersensitivity_rea2.44405056
16MP0003763_abnormal_thymus_physiology2.40782660
17MP0005451_abnormal_body_composition2.30301318
18MP0005025_abnormal_response_to2.30057715
19MP0002420_abnormal_adaptive_immunity2.24018391
20MP0001819_abnormal_immune_cell2.20552028
21MP0004947_skin_inflammation2.16256655
22MP0003172_abnormal_lysosome_physiology2.04968214
23MP0003191_abnormal_cellular_cholesterol2.01238852
24MP0004381_abnormal_hair_follicle2.00124237
25MP0002405_respiratory_system_inflammati1.96893694
26MP0001853_heart_inflammation1.96834670
27MP0006082_CNS_inflammation1.91046919
28MP0003300_gastrointestinal_ulcer1.88885839
29MP0009840_abnormal_foam_cell1.87946297
30MP0002398_abnormal_bone_marrow1.83837055
31MP0005464_abnormal_platelet_physiology1.79425337
32MP0000716_abnormal_immune_system1.79027073
33MP0008004_abnormal_stomach_pH1.76082296
34MP0002138_abnormal_hepatobiliary_system1.71860783
35MP0002166_altered_tumor_susceptibility1.71410609
36MP0001845_abnormal_inflammatory_respons1.68048808
37MP0009333_abnormal_splenocyte_physiolog1.64714239
38MP0001533_abnormal_skeleton_physiology1.60321264
39MP0010155_abnormal_intestine_physiology1.58715572
40MP0005058_abnormal_lysosome_morphology1.57298601
41MP0000689_abnormal_spleen_morphology1.55320992
42MP0009764_decreased_sensitivity_to1.49296567
43MP0003195_calcinosis1.48318598
44MP0002722_abnormal_immune_system1.47557444
45MP0008057_abnormal_DNA_replication1.47230673
46MP0002429_abnormal_blood_cell1.40580848
47MP0002006_tumorigenesis1.38938394
48MP0005310_abnormal_salivary_gland1.37077895
49MP0008469_abnormal_protein_level1.35966823
50MP0009278_abnormal_bone_marrow1.34688581
51MP0000703_abnormal_thymus_morphology1.33201685
52MP0002139_abnormal_hepatobiliary_system1.32491864
53MP0002009_preneoplasia1.30870072
54MP0002998_abnormal_bone_remodeling1.28224177
55MP0004510_myositis1.26921869
56MP0001545_abnormal_hematopoietic_system1.25000941
57MP0005397_hematopoietic_system_phenotyp1.25000941
58MP0003183_abnormal_peptide_metabolism1.22472372
59MP0003656_abnormal_erythrocyte_physiolo1.22012014
60MP0005075_abnormal_melanosome_morpholog1.20677398
61MP0002396_abnormal_hematopoietic_system1.20581604
62MP0001986_abnormal_taste_sensitivity1.19671538
63MP0004808_abnormal_hematopoietic_stem1.15071543
64MP0005167_abnormal_blood-brain_barrier1.14972735
65MP0001873_stomach_inflammation1.14295121
66MP0000858_altered_metastatic_potential1.09654384
67MP0004883_abnormal_blood_vessel1.08223420
68MP0008260_abnormal_autophagy1.03362901
69MP0005164_abnormal_response_to1.03256341
70MP0003075_altered_response_to1.02031257
71MP0008995_early_reproductive_senescence1.00816830
72MP0001851_eye_inflammation0.94759235
73MP0003828_pulmonary_edema0.94351080
74MP0003091_abnormal_cell_migration0.93018205
75MP0009763_increased_sensitivity_to0.91494906
76MP0003448_altered_tumor_morphology0.91133086
77MP0003045_fibrosis0.89080701
78MP0002332_abnormal_exercise_endurance0.89038706
79MP0002254_reproductive_system_inflammat0.86912517
80MP0000371_diluted_coat_color0.85990096
81MP0009765_abnormal_xenobiotic_induced0.84757765
82MP0003690_abnormal_glial_cell0.83826867
83MP0003866_abnormal_defecation0.82852107
84MP0000609_abnormal_liver_physiology0.81458915
85MP0000604_amyloidosis0.78618553
86MP0005166_decreased_susceptibility_to0.76640079
87MP0002933_joint_inflammation0.74640052
88MP0000465_gastrointestinal_hemorrhage0.74366663
89MP0000015_abnormal_ear_pigmentation0.74121909
90MP0002132_abnormal_respiratory_system0.71591622
91MP0000249_abnormal_blood_vessel0.70883452
92MP0003453_abnormal_keratinocyte_physiol0.70737923
93MP0006054_spinal_hemorrhage0.70113699
94MP0005360_urolithiasis0.65997593
95MP0003795_abnormal_bone_structure0.63972572
96MP0005535_abnormal_body_temperature0.63688168
97MP0004185_abnormal_adipocyte_glucose0.61634133
98MP0000343_altered_response_to0.60267279
99MP0002019_abnormal_tumor_incidence0.60075901
100MP0005076_abnormal_cell_differentiation0.59658574

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.00150245
2Recurrent bacterial skin infections (HP:0005406)4.48565048
3Retrobulbar optic neuritis (HP:0100654)4.44448513
4Optic neuritis (HP:0100653)4.44448513
5Recurrent fungal infections (HP:0002841)4.39039949
6Myositis (HP:0100614)4.32658419
7Eczematoid dermatitis (HP:0000976)4.30637470
8Orchitis (HP:0100796)4.22605901
9Chronic mucocutaneous candidiasis (HP:0002728)4.12516461
10Recurrent cutaneous fungal infections (HP:0011370)4.12516461
11Stomatitis (HP:0010280)4.06858435
12Recurrent abscess formation (HP:0002722)4.04855750
13Mediastinal lymphadenopathy (HP:0100721)4.00752074
14Abnormality of macrophages (HP:0004311)3.92397822
15Recurrent viral infections (HP:0004429)3.82202215
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.70926522
17Recurrent skin infections (HP:0001581)3.60955531
18Vasculitis (HP:0002633)3.50025327
19Meningitis (HP:0001287)3.48673299
20Gastrointestinal infarctions (HP:0005244)3.47228367
21T lymphocytopenia (HP:0005403)3.44357150
22Encephalitis (HP:0002383)3.26710602
23Abnormality of T cell number (HP:0011839)3.26451363
24Keratoconjunctivitis sicca (HP:0001097)3.19276776
25Hemoptysis (HP:0002105)3.13089147
26Amyloidosis (HP:0011034)3.11595595
27Colitis (HP:0002583)3.11148247
28Recurrent gram-negative bacterial infections (HP:0005420)2.99834474
29Panhypogammaglobulinemia (HP:0003139)2.98837299
30Keratoconjunctivitis (HP:0001096)2.97238744
31Arterial thrombosis (HP:0004420)2.90171837
32Pulmonary infiltrates (HP:0002113)2.86884486
33Abnormality of T cells (HP:0002843)2.83447390
34Gingival bleeding (HP:0000225)2.82652429
35Anorexia (HP:0002039)2.82438413
36Spontaneous hematomas (HP:0007420)2.73265206
37Leukocytosis (HP:0001974)2.72715175
38Abnormality of liposaccharide metabolism (HP:0010968)2.71887476
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.71887476
40Abnormality of glycolipid metabolism (HP:0010969)2.71887476
41Vacuolated lymphocytes (HP:0001922)2.70339093
42Fatigue (HP:0012378)2.69817850
43Autoimmune hemolytic anemia (HP:0001890)2.69450466
44Autoimmune thrombocytopenia (HP:0001973)2.67743864
45Inflammation of the large intestine (HP:0002037)2.66592047
46Gangrene (HP:0100758)2.61970049
47Pustule (HP:0200039)2.59840640
48Joint swelling (HP:0001386)2.57928737
49Recurrent bronchitis (HP:0002837)2.55325788
50Obstructive lung disease (HP:0006536)2.52840115
51Chronic obstructive pulmonary disease (HP:0006510)2.52840115
52Epistaxis (HP:0000421)2.50631191
53Hematochezia (HP:0002573)2.49273172
54Gastrointestinal inflammation (HP:0004386)2.47421231
55Chest pain (HP:0100749)2.47150221
56Abnormality of the peritoneum (HP:0002585)2.46714879
57Abnormality of the fingertips (HP:0001211)2.46142731
58Granulocytopenia (HP:0001913)2.45681792
59Dysostosis multiplex (HP:0000943)2.44725930
60Pulmonary embolism (HP:0002204)2.42953258
61Increased IgE level (HP:0003212)2.42264495
62Abnormality of T cell physiology (HP:0011840)2.41776479
63Agammaglobulinemia (HP:0004432)2.40747325
64Increased cerebral lipofuscin (HP:0011813)2.38403181
65Lymphopenia (HP:0001888)2.36831453
66Abnormality of the pleura (HP:0002103)2.36176870
67Gastrointestinal stroma tumor (HP:0100723)2.34917276
68Myocardial infarction (HP:0001658)2.34368291
69Neoplasm of the tracheobronchial system (HP:0100552)2.32828328
70Alveolar cell carcinoma (HP:0006519)2.30342172
71Abnormality of the endocardium (HP:0004306)2.29705432
72Polyneuropathy (HP:0001271)2.29522226
73Viral hepatitis (HP:0006562)2.26557541
74Episodic fever (HP:0001954)2.19463949
75Prolonged bleeding time (HP:0003010)2.18493851
76Chronic otitis media (HP:0000389)2.17936500
77Abnormality of eosinophils (HP:0001879)2.17791420
78Urticaria (HP:0001025)2.17670153
79Thrombophlebitis (HP:0004418)2.17452247
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.17060395
81Severe combined immunodeficiency (HP:0004430)2.15681457
82Eosinophilia (HP:0001880)2.11984619
83Chronic diarrhea (HP:0002028)2.10268658
84Increased serum ferritin (HP:0003281)2.09904130
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05974703
86Cellulitis (HP:0100658)2.04972909
87Restrictive lung disease (HP:0002091)2.03362969
88Abnormality of B cell number (HP:0010975)2.03082836
89Hypergammaglobulinemia (HP:0010702)2.02973074
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.00419085
91Gingivitis (HP:0000230)1.99536619
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99021799
93Abnormality of alanine metabolism (HP:0010916)1.99021799
94Hyperalaninemia (HP:0003348)1.99021799
95Nausea (HP:0002018)1.96952809
96Loss of speech (HP:0002371)1.96464558
97Vertigo (HP:0002321)1.95963700
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94706065
99Combined immunodeficiency (HP:0005387)1.94347351
100Amaurosis fugax (HP:0100576)1.93837707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.65328231
2MAP4K13.34656452
3MAP3K142.96640245
4BLK2.90692795
5IRAK32.68219438
6PRPF4B2.66070179
7TYK22.59893078
8JAK32.28318029
9IRAK42.24983490
10IKBKE2.16955163
11MAP2K32.09572028
12CSK1.95975988
13IKBKB1.95632924
14TXK1.95619907
15FGR1.91569943
16TAOK31.84588528
17JAK11.83302147
18IRAK21.81832604
19IRAK11.78057984
20ZAP701.69172076
21SYK1.63929874
22KSR21.58248981
23ERN11.55410052
24BMPR21.51073888
25FES1.50648476
26TBK11.50468490
27MAP3K131.45753179
28MAP3K31.45301644
29BTK1.43331052
30CHUK1.35285895
31FGFR31.33694427
32JAK21.32271640
33SIK31.32269514
34MATK1.32082276
35GRK61.29128163
36CSF1R1.27357124
37TAOK21.27112238
38PDK21.25851857
39HCK1.25143954
40MAP3K21.23345663
41MAP3K11.22777938
42SIK21.22205396
43CDK121.18418177
44MARK31.17258585
45LYN1.16328138
46ACVR1B1.11020615
47MAP3K111.07462897
48MAPK111.05077171
49LCK1.04583206
50ITK1.04404159
51STK101.01683182
52FGFR40.97855174
53PIM10.97603440
54TEC0.94290791
55SGK20.93272399
56SGK30.89654551
57KSR10.86965620
58TRPM70.86706530
59TAOK10.84205793
60PDK10.84076047
61GRK70.79761255
62PIK3CG0.78021518
63MAP3K50.77396542
64KIT0.76623255
65CDC42BPA0.75732169
66CDK40.73522626
67RAF10.73182835
68BRD40.69956119
69NLK0.64235823
70PDPK10.62575472
71YES10.58493923
72MARK20.58029644
73TYRO30.57932475
74PRKCQ0.57823089
75CDK60.53670076
76EPHA30.50493444
77TNK20.50403628
78DYRK1B0.47867190
79MAPK70.47650222
80EPHB10.47624517
81WNK10.47348644
82HIPK20.46725404
83CAMKK20.45171804
84STK40.44701177
85NEK60.41209201
86AKT30.40268531
87SGK2230.39738594
88SGK4940.39738594
89MAP2K20.38328228
90EGFR0.36818750
91MAPK30.35817802
92MOS0.34768501
93MAP2K60.34470530
94NEK90.33085257
95PDGFRB0.32080827
96PKN10.31676055
97RPS6KC10.31286991
98RPS6KL10.31286991
99STK240.29226602
100CAMK1D0.28946979

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.81579425
2Allograft rejection_Homo sapiens_hsa053302.57905529
3Osteoclast differentiation_Homo sapiens_hsa043802.56841943
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.47983670
5Other glycan degradation_Homo sapiens_hsa005112.45215906
6Graft-versus-host disease_Homo sapiens_hsa053322.40838495
7B cell receptor signaling pathway_Homo sapiens_hsa046622.38477629
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34423136
9Staphylococcus aureus infection_Homo sapiens_hsa051502.33473745
10Primary immunodeficiency_Homo sapiens_hsa053402.31146760
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27680212
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19898213
13Autoimmune thyroid disease_Homo sapiens_hsa053202.16950321
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.13768497
15Tuberculosis_Homo sapiens_hsa051522.07223882
16TNF signaling pathway_Homo sapiens_hsa046681.91539163
17Asthma_Homo sapiens_hsa053101.89550029
18Type I diabetes mellitus_Homo sapiens_hsa049401.87921348
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85257202
20Legionellosis_Homo sapiens_hsa051341.83366180
21T cell receptor signaling pathway_Homo sapiens_hsa046601.80490701
22Measles_Homo sapiens_hsa051621.75345717
23Influenza A_Homo sapiens_hsa051641.75013012
24Hematopoietic cell lineage_Homo sapiens_hsa046401.70120981
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.61096122
26Toxoplasmosis_Homo sapiens_hsa051451.59658805
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58563918
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58273217
29Rheumatoid arthritis_Homo sapiens_hsa053231.57741614
30Herpes simplex infection_Homo sapiens_hsa051681.53797392
31Acute myeloid leukemia_Homo sapiens_hsa052211.52845758
32Pertussis_Homo sapiens_hsa051331.48808948
33African trypanosomiasis_Homo sapiens_hsa051431.45444825
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41924744
35Antigen processing and presentation_Homo sapiens_hsa046121.41074130
36Hepatitis B_Homo sapiens_hsa051611.40885839
37Malaria_Homo sapiens_hsa051441.40810434
38Chemokine signaling pathway_Homo sapiens_hsa040621.31244912
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30513161
40Non-small cell lung cancer_Homo sapiens_hsa052231.24917159
41Hepatitis C_Homo sapiens_hsa051601.23699711
42Viral myocarditis_Homo sapiens_hsa054161.10828606
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10077109
44Dorso-ventral axis formation_Homo sapiens_hsa043201.07816064
45Prolactin signaling pathway_Homo sapiens_hsa049171.05628645
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99382889
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.97152546
48Apoptosis_Homo sapiens_hsa042100.95553110
49Lysosome_Homo sapiens_hsa041420.92740283
50Viral carcinogenesis_Homo sapiens_hsa052030.91683752
51Pancreatic cancer_Homo sapiens_hsa052120.91474470
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89488044
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88982514
54VEGF signaling pathway_Homo sapiens_hsa043700.84827748
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.84770174
56Platelet activation_Homo sapiens_hsa046110.84469830
57Phagosome_Homo sapiens_hsa041450.83243149
58Epstein-Barr virus infection_Homo sapiens_hsa051690.81915277
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.76265502
60Chronic myeloid leukemia_Homo sapiens_hsa052200.73088320
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71380128
62FoxO signaling pathway_Homo sapiens_hsa040680.70171730
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70170215
64Complement and coagulation cascades_Homo sapiens_hsa046100.70108904
65Shigellosis_Homo sapiens_hsa051310.67978113
66Systemic lupus erythematosus_Homo sapiens_hsa053220.66136884
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.65265695
68Salmonella infection_Homo sapiens_hsa051320.64382728
69Collecting duct acid secretion_Homo sapiens_hsa049660.62472649
70Bladder cancer_Homo sapiens_hsa052190.61906164
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61855379
72Endometrial cancer_Homo sapiens_hsa052130.61711646
73Sphingolipid metabolism_Homo sapiens_hsa006000.60875352
74ABC transporters_Homo sapiens_hsa020100.59599404
75GnRH signaling pathway_Homo sapiens_hsa049120.59359434
76Renal cell carcinoma_Homo sapiens_hsa052110.57195138
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56190866
78Insulin resistance_Homo sapiens_hsa049310.52897154
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49149713
80Choline metabolism in cancer_Homo sapiens_hsa052310.46551267
81HTLV-I infection_Homo sapiens_hsa051660.46112225
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.45529252
83Type II diabetes mellitus_Homo sapiens_hsa049300.45394283
84MAPK signaling pathway_Homo sapiens_hsa040100.44569027
85Prostate cancer_Homo sapiens_hsa052150.44491930
86ErbB signaling pathway_Homo sapiens_hsa040120.43513978
87mTOR signaling pathway_Homo sapiens_hsa041500.43496877
88Inositol phosphate metabolism_Homo sapiens_hsa005620.42890421
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42812439
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41947093
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.40185815
92HIF-1 signaling pathway_Homo sapiens_hsa040660.40180685
93Amoebiasis_Homo sapiens_hsa051460.37518498
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35589312
95Glioma_Homo sapiens_hsa052140.34871860
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28420218
97Estrogen signaling pathway_Homo sapiens_hsa049150.26709880
98Colorectal cancer_Homo sapiens_hsa052100.25867411
99Vitamin digestion and absorption_Homo sapiens_hsa049770.25234170
100Notch signaling pathway_Homo sapiens_hsa043300.23323007

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