NOP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.79956424
2nuclear pore complex assembly (GO:0051292)4.75996583
3formation of translation preinitiation complex (GO:0001731)4.49332426
4DNA unwinding involved in DNA replication (GO:0006268)4.38249290
5protein localization to kinetochore (GO:0034501)4.32641639
6mitotic nuclear envelope disassembly (GO:0007077)4.31527327
7DNA replication initiation (GO:0006270)4.24881029
8folic acid-containing compound biosynthetic process (GO:0009396)4.23263828
9ribosome assembly (GO:0042255)4.23093060
10* maturation of SSU-rRNA (GO:0030490)4.18424885
11DNA strand elongation involved in DNA replication (GO:0006271)4.13476192
12ribosome biogenesis (GO:0042254)4.09606139
13mitotic metaphase plate congression (GO:0007080)4.07463761
14nucleobase biosynthetic process (GO:0046112)4.05298260
15spliceosomal tri-snRNP complex assembly (GO:0000244)4.03701709
16nuclear envelope disassembly (GO:0051081)4.01330425
17membrane disassembly (GO:0030397)4.01330425
18DNA replication checkpoint (GO:0000076)3.92447562
19DNA strand elongation (GO:0022616)3.91713863
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.89312537
21IMP biosynthetic process (GO:0006188)3.87725288
22DNA replication-dependent nucleosome assembly (GO:0006335)3.83508154
23DNA replication-dependent nucleosome organization (GO:0034723)3.83508154
24purine nucleobase biosynthetic process (GO:0009113)3.79593203
25* ribonucleoprotein complex biogenesis (GO:0022613)3.75927359
26ribosomal large subunit biogenesis (GO:0042273)3.74602238
27telomere maintenance via semi-conservative replication (GO:0032201)3.66516921
28protein localization to chromosome, centromeric region (GO:0071459)3.66349694
29pore complex assembly (GO:0046931)3.62491511
30ribosomal small subunit assembly (GO:0000028)3.60553812
31heterochromatin organization (GO:0070828)3.56606555
32DNA topological change (GO:0006265)3.56277060
33IMP metabolic process (GO:0046040)3.54518926
34metaphase plate congression (GO:0051310)3.52934360
35chromatin remodeling at centromere (GO:0031055)3.45422538
36* rRNA processing (GO:0006364)3.40290303
37telomere maintenance via recombination (GO:0000722)3.39001316
38translational initiation (GO:0006413)3.36767466
39regulation of nucleobase-containing compound transport (GO:0032239)3.36070576
40translational termination (GO:0006415)3.33785686
41CENP-A containing nucleosome assembly (GO:0034080)3.33783977
42regulation of gene silencing by RNA (GO:0060966)3.33276841
43regulation of posttranscriptional gene silencing (GO:0060147)3.33276841
44regulation of gene silencing by miRNA (GO:0060964)3.33276841
45mitotic sister chromatid segregation (GO:0000070)3.33096028
46regulation of spindle organization (GO:0090224)3.32601654
47viral transcription (GO:0019083)3.32584640
48kinetochore organization (GO:0051383)3.30400379
49* rRNA metabolic process (GO:0016072)3.29824949
50DNA geometric change (GO:0032392)3.28496758
51DNA duplex unwinding (GO:0032508)3.28491762
52mitotic recombination (GO:0006312)3.27030767
53COPI coating of Golgi vesicle (GO:0048205)3.26284206
54Golgi transport vesicle coating (GO:0048200)3.26284206
55negative regulation of mRNA processing (GO:0050686)3.25968314
56DNA replication-independent nucleosome organization (GO:0034724)3.24228894
57DNA replication-independent nucleosome assembly (GO:0006336)3.24228894
58nucleobase-containing small molecule interconversion (GO:0015949)3.24221011
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19735434
60negative regulation of mRNA metabolic process (GO:1903312)3.18119220
61protein export from nucleus (GO:0006611)3.16572950
62spliceosomal snRNP assembly (GO:0000387)3.16000518
63telomere maintenance via telomere lengthening (GO:0010833)3.14932328
64mitotic sister chromatid cohesion (GO:0007064)3.12960061
65nuclear envelope organization (GO:0006998)3.10857905
66mitotic chromosome condensation (GO:0007076)3.09427768
67chromosome condensation (GO:0030261)3.09262939
68protein complex localization (GO:0031503)3.09043124
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08486281
70establishment of chromosome localization (GO:0051303)3.08168828
71regulation of histone H3-K27 methylation (GO:0061085)3.07306855
72sister chromatid segregation (GO:0000819)3.05714872
73mRNA stabilization (GO:0048255)3.05588971
74RNA stabilization (GO:0043489)3.05588971
75translational elongation (GO:0006414)3.05560059
76histone exchange (GO:0043486)3.05342163
77proline biosynthetic process (GO:0006561)3.04203070
78maturation of 5.8S rRNA (GO:0000460)3.03323043
79regulation of mitotic spindle organization (GO:0060236)3.03076746
80peptidyl-arginine omega-N-methylation (GO:0035247)3.02923523
81regulation of histone H3-K9 methylation (GO:0051570)3.02615776
82cellular protein complex localization (GO:0034629)3.01056134
83* ribosomal small subunit biogenesis (GO:0042274)2.99542341
84pre-miRNA processing (GO:0031054)2.98422383
85positive regulation of chromosome segregation (GO:0051984)2.97430195
86negative regulation of RNA splicing (GO:0033119)2.97018139
87protein K6-linked ubiquitination (GO:0085020)2.95520449
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.95266052
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95266052
90viral mRNA export from host cell nucleus (GO:0046784)2.95155843
91regulation of helicase activity (GO:0051095)2.92134068
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.91744908
93attachment of spindle microtubules to kinetochore (GO:0008608)2.90557538
94pseudouridine synthesis (GO:0001522)2.90425473
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.89697593
96negative regulation of histone methylation (GO:0031061)2.89023635
97RNA splicing, via transesterification reactions (GO:0000375)2.88447912
98tRNA aminoacylation for protein translation (GO:0006418)2.88079959
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87723620
100meiotic chromosome segregation (GO:0045132)2.87447468
101chromatin assembly or disassembly (GO:0006333)2.86635584
102regulation of translational fidelity (GO:0006450)2.86452365
103kinetochore assembly (GO:0051382)2.86099556
104mRNA splicing, via spliceosome (GO:0000398)2.85160010
105RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85160010
106regulation of centrosome cycle (GO:0046605)2.84395565
107spindle checkpoint (GO:0031577)2.82938816
108rRNA transcription (GO:0009303)2.81559521
109regulation of translational termination (GO:0006449)2.81003474
110tRNA aminoacylation (GO:0043039)2.80565750
111amino acid activation (GO:0043038)2.80565750
112regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80077313
113DNA conformation change (GO:0071103)2.79832220
114folic acid metabolic process (GO:0046655)2.79378997
115negative regulation of chromosome segregation (GO:0051985)2.77551119
116DNA packaging (GO:0006323)2.77472858
117double-strand break repair via nonhomologous end joining (GO:0006303)2.76438323
118non-recombinational repair (GO:0000726)2.76438323
119protein localization to chromosome (GO:0034502)2.76184267
120mitotic spindle checkpoint (GO:0071174)2.75491496
121ATP-dependent chromatin remodeling (GO:0043044)2.74571141
122chromatin assembly (GO:0031497)2.74354026
123regulation of RNA export from nucleus (GO:0046831)2.74163987
124spliceosomal complex assembly (GO:0000245)2.73913365
125mRNA transport (GO:0051028)2.73307038
126regulation of translational elongation (GO:0006448)2.73064681
127establishment of integrated proviral latency (GO:0075713)2.73039976
128negative regulation of sister chromatid segregation (GO:0033046)2.71853909
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71853909
130DNA synthesis involved in DNA repair (GO:0000731)2.69693709
1313-UTR-mediated mRNA stabilization (GO:0070935)2.67380401
132tetrahydrofolate metabolic process (GO:0046653)2.66026627
133transcription from mitochondrial promoter (GO:0006390)2.62371716
134mRNA export from nucleus (GO:0006406)2.60016210
135regulation of sister chromatid cohesion (GO:0007063)2.56581443
136negative regulation of DNA repair (GO:0045738)2.56341486
137RNA export from nucleus (GO:0006405)2.55085227
138glucocorticoid receptor signaling pathway (GO:0042921)2.52226143
139dosage compensation (GO:0007549)2.52181790
140histone H2B ubiquitination (GO:0033523)2.52105850
141positive regulation of DNA-dependent DNA replication (GO:2000105)2.50671178
142nucleosome disassembly (GO:0006337)2.50565074
143protein-DNA complex disassembly (GO:0032986)2.50565074
144nuclear export (GO:0051168)2.50150980
145positive regulation of keratinocyte differentiation (GO:0045618)2.49015061
146peptidyl-arginine N-methylation (GO:0035246)2.47646094
147peptidyl-arginine methylation (GO:0018216)2.47646094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.58821682
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58935530
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.88021810
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69816767
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42844577
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26311396
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10499397
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93875533
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78699877
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72854208
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.61008700
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56918041
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.50372259
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47424271
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45918381
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.45153552
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44198075
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37224905
19XRN2_22483619_ChIP-Seq_HELA_Human2.33607271
20AR_21909140_ChIP-Seq_LNCAP_Human2.23387614
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20571604
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17081649
23* VDR_23849224_ChIP-Seq_CD4+_Human2.07490539
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.06284369
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04808370
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01294919
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97812645
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.91574507
29* TTF2_22483619_ChIP-Seq_HELA_Human1.88367771
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87925621
31DCP1A_22483619_ChIP-Seq_HELA_Human1.87448286
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86715368
33FOXP3_21729870_ChIP-Seq_TREG_Human1.85129677
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73884183
35GABP_19822575_ChIP-Seq_HepG2_Human1.71683715
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70714988
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68534180
38MYC_22102868_ChIP-Seq_BL_Human1.68464282
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64345474
40ELK1_19687146_ChIP-ChIP_HELA_Human1.63812843
41ZNF263_19887448_ChIP-Seq_K562_Human1.62703149
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62550229
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62109631
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56709540
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55499007
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54737088
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54607988
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54430379
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52057006
50KDM5A_27292631_Chip-Seq_BREAST_Human1.48683526
51CIITA_25753668_ChIP-Seq_RAJI_Human1.47270136
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.46464839
53* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46046209
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45354928
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42002805
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42002805
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42002805
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41283602
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37863591
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34768674
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.33178401
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.32982806
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32045137
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31064689
65TFEB_21752829_ChIP-Seq_HELA_Human1.30917318
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29118200
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28848975
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26352564
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.26330042
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23982439
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23572083
72* NOTCH1_21737748_ChIP-Seq_TLL_Human1.23245728
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22927502
74CHD1_26751641_Chip-Seq_LNCaP_Human1.22605693
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22015034
76MAF_26560356_Chip-Seq_TH1_Human1.19236049
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18490530
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17757101
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17460950
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16492740
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16459002
82TCF7_22412390_ChIP-Seq_EML_Mouse1.14426909
83* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13737819
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13065726
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12147806
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11093701
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10330343
88RACK7_27058665_Chip-Seq_MCF-7_Human1.10328385
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10067240
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09101728
91ATF3_27146783_Chip-Seq_COLON_Human1.09074107
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07942510
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07647799
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07141424
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05529956
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04266009
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03582972
98* MAF_26560356_Chip-Seq_TH2_Human1.03439780
99NCOR1_26117541_ChIP-Seq_K562_Human1.02932723
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02860580
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02306666
102CLOCK_20551151_ChIP-Seq_293T_Human1.02065509
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.01311409
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00474419
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99709655
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98765325
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95417683
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.95059892
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95027276
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94901884
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94392006
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93874689
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93709987
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92439394
115MYB_26560356_Chip-Seq_TH1_Human0.92106967
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91735617
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90997472
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90809999
119UTX_26944678_Chip-Seq_JUKART_Human0.90252097
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89224436
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87582797
122MYC_18940864_ChIP-ChIP_HL60_Human0.87184125
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87120032
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87047313
125TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85676518
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.85196448
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84271963
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83904650
129VDR_21846776_ChIP-Seq_THP-1_Human0.81850522
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81681308
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81453819
132NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80407935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.00545106
2MP0004957_abnormal_blastocyst_morpholog4.28967955
3MP0010094_abnormal_chromosome_stability4.25970343
4MP0003111_abnormal_nucleus_morphology4.06130926
5MP0008057_abnormal_DNA_replication4.05110287
6MP0003077_abnormal_cell_cycle3.73726532
7MP0008058_abnormal_DNA_repair2.97755346
8MP0010352_gastrointestinal_tract_polyps2.79513711
9MP0008007_abnormal_cellular_replicative2.76128736
10MP0005451_abnormal_body_composition2.74470794
11MP0008932_abnormal_embryonic_tissue2.53381664
12MP0001730_embryonic_growth_arrest2.50057984
13MP0000350_abnormal_cell_proliferation2.36414932
14MP0003123_paternal_imprinting2.30276526
15MP0010234_abnormal_vibrissa_follicle2.28088144
16MP0008877_abnormal_DNA_methylation2.22338346
17MP0004185_abnormal_adipocyte_glucose2.10834303
18MP0002396_abnormal_hematopoietic_system2.06752430
19MP0010307_abnormal_tumor_latency2.04771252
20MP0004233_abnormal_muscle_weight2.04723907
21MP0005380_embryogenesis_phenotype2.00085358
22MP0001672_abnormal_embryogenesis/_devel2.00085358
23MP0003786_premature_aging1.92097228
24MP0001697_abnormal_embryo_size1.85276294
25MP0003984_embryonic_growth_retardation1.83202594
26MP0002088_abnormal_embryonic_growth/wei1.79793502
27MP0002085_abnormal_embryonic_tissue1.73685718
28MP0005076_abnormal_cell_differentiation1.72841474
29MP0002084_abnormal_developmental_patter1.72465040
30MP0004197_abnormal_fetal_growth/weight/1.72398272
31MP0002080_prenatal_lethality1.67816743
32MP0002009_preneoplasia1.66452187
33MP0002086_abnormal_extraembryonic_tissu1.60879676
34MP0003890_abnormal_embryonic-extraembry1.53109239
35MP0001873_stomach_inflammation1.49040366
36MP0000490_abnormal_crypts_of1.48712821
37MP0003567_abnormal_fetal_cardiomyocyte1.47818491
38MP0010030_abnormal_orbit_morphology1.46829263
39MP0005501_abnormal_skin_physiology1.45419980
40MP0002796_impaired_skin_barrier1.44284738
41MP0003705_abnormal_hypodermis_morpholog1.41893595
42MP0002166_altered_tumor_susceptibility1.41047122
43MP0000313_abnormal_cell_death1.40081218
44MP0004808_abnormal_hematopoietic_stem1.39631722
45MP0001293_anophthalmia1.36671229
46MP0003718_maternal_effect1.32156401
47MP0001661_extended_life_span1.31543249
48MP0002210_abnormal_sex_determination1.31045415
49MP0003453_abnormal_keratinocyte_physiol1.27369825
50MP0002019_abnormal_tumor_incidence1.26695228
51MP0001348_abnormal_lacrimal_gland1.23984762
52MP0002006_tumorigenesis1.20511946
53MP0003121_genomic_imprinting1.17479162
54MP0009333_abnormal_splenocyte_physiolog1.16318598
55MP0001145_abnormal_male_reproductive1.13269404
56MP0003300_gastrointestinal_ulcer1.11753005
57MP0003806_abnormal_nucleotide_metabolis1.10045894
58MP0003566_abnormal_cell_adhesion1.09653970
59MP0000537_abnormal_urethra_morphology1.08313587
60MP0001216_abnormal_epidermal_layer1.08238314
61MP0003119_abnormal_digestive_system1.07753948
62MP0005023_abnormal_wound_healing1.06783382
63MP0001929_abnormal_gametogenesis1.06139039
64MP0002060_abnormal_skin_morphology1.05517298
65MP0009053_abnormal_anal_canal1.04461898
66MP0004133_heterotaxia1.04432075
67MP0009672_abnormal_birth_weight1.03879453
68MP0004264_abnormal_extraembryonic_tissu1.00521397
69MP0000703_abnormal_thymus_morphology0.99694764
70MP0003937_abnormal_limbs/digits/tail_de0.96910391
71MP0002111_abnormal_tail_morphology0.95325056
72MP0003315_abnormal_perineum_morphology0.94432255
73MP0005623_abnormal_meninges_morphology0.93641071
74MP0000653_abnormal_sex_gland0.93216380
75MP0003941_abnormal_skin_development0.92847034
76MP0005666_abnormal_adipose_tissue0.92471291
77MP0000858_altered_metastatic_potential0.91962301
78MP0003763_abnormal_thymus_physiology0.91626554
79MP0000428_abnormal_craniofacial_morphol0.90924720
80MP0004947_skin_inflammation0.90247305
81MP0002653_abnormal_ependyma_morphology0.89766650
82MP0006035_abnormal_mitochondrial_morpho0.89460032
83MP0009703_decreased_birth_body0.88646860
84MP0000685_abnormal_immune_system0.88501668
85MP0005397_hematopoietic_system_phenotyp0.88136352
86MP0001545_abnormal_hematopoietic_system0.88136352
87MP0001881_abnormal_mammary_gland0.87256469
88MP0005621_abnormal_cell_physiology0.87066863
89MP0009697_abnormal_copulation0.86886595
90MP0003091_abnormal_cell_migration0.86535719
91MP0000678_abnormal_parathyroid_gland0.85561221
92MP0001915_intracranial_hemorrhage0.85423088
93MP0008260_abnormal_autophagy0.84842394
94MP0000627_abnormal_mammary_gland0.84722517
95MP0002160_abnormal_reproductive_system0.84060673
96MP0005384_cellular_phenotype0.83852502
97MP0000003_abnormal_adipose_tissue0.83733642
98MP0000733_abnormal_muscle_development0.83204971
99MP0000432_abnormal_head_morphology0.82855452
100MP0003656_abnormal_erythrocyte_physiolo0.81883503
101MP0004782_abnormal_surfactant_physiolog0.79890632
102MP0002398_abnormal_bone_marrow0.79715896
103MP0009931_abnormal_skin_appearance0.79259545
104MP0002092_abnormal_eye_morphology0.78915737
105MP0002877_abnormal_melanocyte_morpholog0.78889504
106MP0002722_abnormal_immune_system0.78334134
107MP0001727_abnormal_embryo_implantation0.78245571
108MP0003221_abnormal_cardiomyocyte_apopto0.78101443
109MP0005375_adipose_tissue_phenotype0.77600678
110MP0002970_abnormal_white_adipose0.76966930
111MP0001286_abnormal_eye_development0.75791886
112MP0000358_abnormal_cell_content/0.75202208
113MP0000689_abnormal_spleen_morphology0.72663671
114MP0000747_muscle_weakness0.72541269
115MP0001346_abnormal_lacrimal_gland0.71881883
116MP0000750_abnormal_muscle_regeneration0.70763247
117MP0000759_abnormal_skeletal_muscle0.70144345
118MP0002269_muscular_atrophy0.69908330
119MP0005389_reproductive_system_phenotype0.69323986
120MP0008961_abnormal_basal_metabolism0.68095241
121MP0003448_altered_tumor_morphology0.67731238
122MP0001849_ear_inflammation0.67001591
123MP0001119_abnormal_female_reproductive0.66857905
124MP0001853_heart_inflammation0.65862507
125MP0010630_abnormal_cardiac_muscle0.64343278
126MP0002925_abnormal_cardiovascular_devel0.64310786
127MP0002697_abnormal_eye_size0.63695778
128MP0003935_abnormal_craniofacial_develop0.63253187
129MP0003755_abnormal_palate_morphology0.62971673
130MP0000716_abnormal_immune_system0.62745395
131MP0001835_abnormal_antigen_presentation0.62664650
132MP0003436_decreased_susceptibility_to0.62097432
133MP0006292_abnormal_olfactory_placode0.61829438
134MP0005330_cardiomyopathy0.61696939
135MP0000516_abnormal_urinary_system0.61113150
136MP0005367_renal/urinary_system_phenotyp0.61113150
137MP0002429_abnormal_blood_cell0.59258873
138MP0008770_decreased_survivor_rate0.58927127
139MP0002114_abnormal_axial_skeleton0.58310573
140MP0003186_abnormal_redox_activity0.57821816
141MP0003936_abnormal_reproductive_system0.57518073
142MP0003115_abnormal_respiratory_system0.55260018
143MP0000477_abnormal_intestine_morphology0.55025348
144MP0003698_abnormal_male_reproductive0.54922668
145MP0001243_abnormal_dermal_layer0.52768419

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.32242379
2Reticulocytopenia (HP:0001896)3.78825507
3Chromsome breakage (HP:0040012)3.75508752
4Progressive muscle weakness (HP:0003323)3.65976136
5Abnormality of the anterior horn cell (HP:0006802)3.64496577
6Degeneration of anterior horn cells (HP:0002398)3.64496577
7Breast hypoplasia (HP:0003187)3.57882644
8Ependymoma (HP:0002888)3.56415350
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47216999
10Hyperacusis (HP:0010780)3.38179953
11Selective tooth agenesis (HP:0001592)3.37505255
12Medulloblastoma (HP:0002885)3.30849788
13Colon cancer (HP:0003003)3.18354914
14Abnormality of chromosome stability (HP:0003220)3.01431512
15Microvesicular hepatic steatosis (HP:0001414)3.00788820
16Carpal bone hypoplasia (HP:0001498)2.90472954
17Absent thumb (HP:0009777)2.89506108
18Patellar aplasia (HP:0006443)2.88375407
19Meckel diverticulum (HP:0002245)2.85555092
20Impulsivity (HP:0100710)2.84390260
21Progressive external ophthalmoplegia (HP:0000590)2.82360332
22Abnormality of the labia minora (HP:0012880)2.81663554
23Abnormality of cells of the erythroid lineage (HP:0012130)2.80676897
24Abnormality of the preputium (HP:0100587)2.79400538
25Agnosia (HP:0010524)2.78615461
26Rhabdomyosarcoma (HP:0002859)2.78523248
27Absent radius (HP:0003974)2.74258227
28Rough bone trabeculation (HP:0100670)2.73510320
29Abnormality of the ileum (HP:0001549)2.73126443
3011 pairs of ribs (HP:0000878)2.71876893
31Aplasia/Hypoplasia of the patella (HP:0006498)2.70660850
32Trismus (HP:0000211)2.68812172
33Oral leukoplakia (HP:0002745)2.67861206
34Proximal placement of thumb (HP:0009623)2.65022899
35Deviation of the thumb (HP:0009603)2.61825369
36Insomnia (HP:0100785)2.56678623
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.56055204
38Abnormal number of erythroid precursors (HP:0012131)2.55880787
39Myelodysplasia (HP:0002863)2.53703044
40Dysmetric saccades (HP:0000641)2.51740979
41Absent forearm bone (HP:0003953)2.50661785
42Aplasia involving forearm bones (HP:0009822)2.50661785
43Asymmetry of the thorax (HP:0001555)2.49637798
44Abnormality of the astrocytes (HP:0100707)2.47520290
45Astrocytoma (HP:0009592)2.47520290
46Glossoptosis (HP:0000162)2.41288325
47Ragged-red muscle fibers (HP:0003200)2.40366596
48Volvulus (HP:0002580)2.39783004
49Missing ribs (HP:0000921)2.38533293
50Supernumerary spleens (HP:0009799)2.38131464
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.36559261
52Glioma (HP:0009733)2.33927723
53Septate vagina (HP:0001153)2.33235800
54Abnormal number of incisors (HP:0011064)2.32841218
55Neoplasm of the pancreas (HP:0002894)2.32519713
56Atrophy/Degeneration involving motor neurons (HP:0007373)2.29154189
57Ectopic kidney (HP:0000086)2.28225718
58Atresia of the external auditory canal (HP:0000413)2.28189708
59Macrocytic anemia (HP:0001972)2.28122903
60Aplastic anemia (HP:0001915)2.28058858
61Premature ovarian failure (HP:0008209)2.24776026
62Ankyloglossia (HP:0010296)2.19628308
63Spinal muscular atrophy (HP:0007269)2.18399090
64Sloping forehead (HP:0000340)2.18316977
65Duodenal stenosis (HP:0100867)2.18070079
66Small intestinal stenosis (HP:0012848)2.18070079
67Pallor (HP:0000980)2.16470088
68Horseshoe kidney (HP:0000085)2.15651825
69Cerebral hypomyelination (HP:0006808)2.14542298
70Abnormality of the fingertips (HP:0001211)2.14011731
71Squamous cell carcinoma (HP:0002860)2.12921816
72Achilles tendon contracture (HP:0001771)2.10410282
73Aplasia/hypoplasia of the humerus (HP:0006507)2.09322991
74Basal cell carcinoma (HP:0002671)2.08207413
75Entropion (HP:0000621)2.08008506
76Abnormality of oral frenula (HP:0000190)2.05129671
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.05041104
78Increased nuchal translucency (HP:0010880)2.04785475
79Neoplasm of striated muscle (HP:0009728)2.03927040
80Asplenia (HP:0001746)2.03133876
81Urethral obstruction (HP:0000796)2.01453342
82Deep philtrum (HP:0002002)2.01197288
83Deep palmar crease (HP:0006191)2.01183290
84Bone marrow hypocellularity (HP:0005528)2.00191414
85Long palpebral fissure (HP:0000637)1.99565774
86Neoplasm of the oral cavity (HP:0100649)1.98861468
87Abnormality of the calcaneus (HP:0008364)1.98846598
88Tracheoesophageal fistula (HP:0002575)1.98390285
89Abnormal trabecular bone morphology (HP:0100671)1.97959969
90Poikiloderma (HP:0001029)1.97697548
91Premature graying of hair (HP:0002216)1.97613690
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97067924
93Microretrognathia (HP:0000308)1.96901417
94Insidious onset (HP:0003587)1.96723130
95Termporal pattern (HP:0011008)1.96723130
96Distal lower limb amyotrophy (HP:0008944)1.96178101
97Fatigue (HP:0012378)1.95910761
98Syringomyelia (HP:0003396)1.95699153
99Spinal cord lesions (HP:0100561)1.95699153
100IgA deficiency (HP:0002720)1.95591971
101Patellar dislocation (HP:0002999)1.93912740
102Abdominal situs inversus (HP:0003363)1.93442242
103Abnormality of abdominal situs (HP:0011620)1.93442242
104Biliary tract neoplasm (HP:0100574)1.93103271
105Ulnar bowing (HP:0003031)1.93063433
106Rib fusion (HP:0000902)1.91925803
107Multiple enchondromatosis (HP:0005701)1.91532363
108Facial hemangioma (HP:0000329)1.90872758
109Increased connective tissue (HP:0009025)1.90792681
110Recurrent viral infections (HP:0004429)1.90406123
111Triphalangeal thumb (HP:0001199)1.90330481
112Prominent nose (HP:0000448)1.87709077
113Cutaneous melanoma (HP:0012056)1.87044891
114Sparse lateral eyebrow (HP:0005338)1.86789743
115Overlapping toe (HP:0001845)1.86776049
116Abnormality of the duodenum (HP:0002246)1.86270146
117Short thumb (HP:0009778)1.86078719
118Duplicated collecting system (HP:0000081)1.85980744
119Abnormality of the umbilical cord (HP:0010881)1.84445379
120Cholecystitis (HP:0001082)1.84065443
121Abnormal gallbladder physiology (HP:0012438)1.84065443
122Ureteral duplication (HP:0000073)1.83109432
123Progressive hearing impairment (HP:0001730)1.82854128
124Abnormality of the Achilles tendon (HP:0005109)1.82456174
125Cafe-au-lait spot (HP:0000957)1.82020273
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.82018922
127Reticulocytosis (HP:0001923)1.82002679
128Long eyelashes (HP:0000527)1.81383440
129Secondary amenorrhea (HP:0000869)1.80785443
130Acute myeloid leukemia (HP:0004808)1.79696133
131Abnormality of reticulocytes (HP:0004312)1.79032273
132Orthostatic hypotension (HP:0001278)1.79012969
133Abnormality of the thoracic spine (HP:0100711)1.77391854
134Disproportionate tall stature (HP:0001519)1.77329245
135Abnormality of the carotid arteries (HP:0005344)1.76752069
136Short humerus (HP:0005792)1.76058125
137Abnormality of glycolysis (HP:0004366)1.74852254
138Short palpebral fissure (HP:0012745)1.73933937
139Self-mutilation (HP:0000742)1.72419720
140Slender long bone (HP:0003100)1.71849502
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.71798468
142Osteolytic defects of the hand bones (HP:0009699)1.71798468
143Elfin facies (HP:0004428)1.71150734
144Amaurosis fugax (HP:0100576)1.71102135
145Preauricular skin tag (HP:0000384)1.69974178
146Unilateral renal agenesis (HP:0000122)1.69681464
147Overriding aorta (HP:0002623)1.68892983
148Abnormal lung lobation (HP:0002101)1.68745376
149Pelvic girdle muscle weakness (HP:0003749)1.68309532
150Metaphyseal cupping (HP:0003021)1.68291593
151Ridged nail (HP:0001807)1.67168248
152Abnormal umbilical cord blood vessels (HP:0011403)1.66493402
153Single umbilical artery (HP:0001195)1.66493402
154Abnormality of the fetal cardiovascular system (HP:0010948)1.66493402
155Abnormal foot bone ossification (HP:0010675)1.65223183
156Broad face (HP:0000283)1.64712115
157Abnormality of the distal phalanges of the toes (HP:0010182)1.64090482
158Colitis (HP:0002583)1.63759790
159Skull defect (HP:0001362)1.62895241
160Sandal gap (HP:0001852)1.61878408
161High anterior hairline (HP:0009890)1.60608733
162Flat acetabular roof (HP:0003180)1.59848862
163High pitched voice (HP:0001620)1.59719437
164Reduced subcutaneous adipose tissue (HP:0003758)1.58806134
165Persistence of primary teeth (HP:0006335)1.58690875
166Relative macrocephaly (HP:0004482)1.58462113
167Aplasia/Hypoplasia of the thymus (HP:0010515)1.57967405
168Aplasia/Hypoplasia of the sacrum (HP:0008517)1.57174294
169Resting tremor (HP:0002322)1.56674283
170Renal duplication (HP:0000075)1.56588356
171Aplasia cutis congenita (HP:0001057)1.56345718
172Elbow flexion contracture (HP:0002987)1.56167339
173Dislocated radial head (HP:0003083)1.55642184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.48782767
2SMG14.04434746
3WEE13.97705807
4BUB13.26935967
5TRIB33.23733586
6CDK123.17879975
7TSSK62.87877214
8IRAK32.64706230
9EIF2AK12.60655387
10ICK2.55473431
11NEK22.54192828
12TTK2.46112867
13PRPF4B2.39947935
14SRPK12.30543839
15EPHA22.25754251
16BRSK22.14000637
17MKNK12.05586948
18NME21.99092791
19CDK71.96747649
20NEK11.95665264
21PLK11.89200844
22PLK41.85477964
23PASK1.83207562
24PLK31.83010260
25RPS6KB21.76560422
26ATR1.74997855
27ACVR1B1.69289770
28AURKB1.65121888
29MKNK21.62145335
30STK101.59486341
31CHEK11.49445150
32EIF2AK31.48895148
33RPS6KA41.47648316
34SCYL21.44752602
35PNCK1.44566952
36TESK21.40146599
37EEF2K1.38925200
38MAP3K81.35662777
39CHEK21.34844846
40FGFR41.33941887
41MAP3K141.32325317
42SIK11.32034053
43CDK41.28505024
44STK38L1.24464960
45TGFBR11.24441418
46MAP3K131.24210241
47VRK11.23084020
48BRD41.18211696
49DYRK31.15271829
50ALK1.14635117
51MST1R1.13374599
52PBK1.12290289
53STK161.11835037
54AURKA1.10803032
55LATS21.07187352
56BRSK11.06804882
57CLK11.06591815
58ATM1.06509592
59PDK31.01811318
60PDK41.01811318
61CDK21.00889465
62TTN0.97983139
63PAK40.96105378
64TLK10.95928767
65ERN10.93599412
66MAPK110.91076907
67VRK20.90434549
68PIM10.89408942
69CAMK1D0.88771366
70STK30.86195621
71MAP2K30.85742439
72MTOR0.85346842
73PKN20.85326451
74FLT30.85027916
75PDGFRA0.83961856
76CDK60.81810243
77CSNK2A20.81236809
78STK40.80757832
79TESK10.80018239
80ZAK0.74085918
81TAF10.72186450
82MAP3K30.71903439
83CDK10.70394805
84LATS10.69455292
85MELK0.69354541
86MAP4K10.68904640
87ARAF0.67062705
88PAK10.66596280
89CSNK1E0.63660556
90LRRK20.63180072
91CDK90.63100830
92CSNK2A10.62637093
93CAMK1G0.62033347
94PAK20.61124207
95BRAF0.60749928
96KSR20.60710888
97RAF10.60029666
98MAP3K90.58834254
99NEK90.54221870
100EIF2AK20.54146921
101PIM20.53792540
102MAP3K100.52047639
103PRKCI0.51660851
104PDK20.50961575
105MAP3K10.46550111
106TRPM70.44562119
107PRKDC0.44153873
108RPS6KA50.43153418
109IRAK40.42395047
110RIPK10.41790621
111IRAK20.39014013
112ILK0.37982067
113RPS6KB10.37630097
114MAP3K110.36946321
115MST40.36401897
116CDK80.36171665
117AKT20.35822302
118TEC0.35715159
119MAPK140.35560318
120ZAP700.34226691
121SIK30.32713099
122CHUK0.32427447
123MARK30.31357941
124CSNK1D0.31198391
125PTK60.31016131
126KDR0.30978644
127TAOK20.30004458
128STK240.29936006
129MAPK10.28701529
130ERBB40.27154664
131FGFR10.27071203
132NME10.26716167
133CCNB10.26103107
134AKT10.24761988
135GRK60.24119262
136GSK3B0.23440252
137BTK0.22740744

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.41151350
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29770775
3Mismatch repair_Homo sapiens_hsa034303.94885090
4RNA transport_Homo sapiens_hsa030133.53743860
5Spliceosome_Homo sapiens_hsa030403.32045702
6RNA polymerase_Homo sapiens_hsa030203.17349901
7One carbon pool by folate_Homo sapiens_hsa006703.11022050
8Ribosome_Homo sapiens_hsa030103.09999067
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.90948331
10Proteasome_Homo sapiens_hsa030502.87116293
11Homologous recombination_Homo sapiens_hsa034402.83236367
12Nucleotide excision repair_Homo sapiens_hsa034202.67768619
13Base excision repair_Homo sapiens_hsa034102.64228123
14Cell cycle_Homo sapiens_hsa041102.62796794
15Fanconi anemia pathway_Homo sapiens_hsa034602.17298935
16Pyrimidine metabolism_Homo sapiens_hsa002402.14983289
17Non-homologous end-joining_Homo sapiens_hsa034502.09252639
18RNA degradation_Homo sapiens_hsa030182.08976636
19Basal transcription factors_Homo sapiens_hsa030222.05087336
20mRNA surveillance pathway_Homo sapiens_hsa030152.01499850
21p53 signaling pathway_Homo sapiens_hsa041151.67171789
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57208449
23Non-small cell lung cancer_Homo sapiens_hsa052231.49799980
24Epstein-Barr virus infection_Homo sapiens_hsa051691.34963408
25B cell receptor signaling pathway_Homo sapiens_hsa046621.16449143
26Purine metabolism_Homo sapiens_hsa002301.09916516
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06998665
28Antigen processing and presentation_Homo sapiens_hsa046121.05709785
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03851371
30Viral carcinogenesis_Homo sapiens_hsa052031.01941840
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99640814
32Herpes simplex infection_Homo sapiens_hsa051680.97379822
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93188804
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.91798465
35Oocyte meiosis_Homo sapiens_hsa041140.90557241
36Endometrial cancer_Homo sapiens_hsa052130.90400825
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87389756
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.86526672
39MicroRNAs in cancer_Homo sapiens_hsa052060.86360783
40N-Glycan biosynthesis_Homo sapiens_hsa005100.85206990
41HTLV-I infection_Homo sapiens_hsa051660.84837814
42Selenocompound metabolism_Homo sapiens_hsa004500.84424828
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81268710
44Renal cell carcinoma_Homo sapiens_hsa052110.81267684
45Thyroid cancer_Homo sapiens_hsa052160.79026025
46Vitamin B6 metabolism_Homo sapiens_hsa007500.78361174
47Biosynthesis of amino acids_Homo sapiens_hsa012300.77775846
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77772952
49Small cell lung cancer_Homo sapiens_hsa052220.76268720
50VEGF signaling pathway_Homo sapiens_hsa043700.74512831
51Glioma_Homo sapiens_hsa052140.74177598
52Systemic lupus erythematosus_Homo sapiens_hsa053220.72656309
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72027902
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71993367
55TGF-beta signaling pathway_Homo sapiens_hsa043500.70909792
56Pentose phosphate pathway_Homo sapiens_hsa000300.69454415
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69250024
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64534741
59Insulin signaling pathway_Homo sapiens_hsa049100.63814909
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63384116
61Hippo signaling pathway_Homo sapiens_hsa043900.62783781
62Legionellosis_Homo sapiens_hsa051340.62172712
63Hepatitis C_Homo sapiens_hsa051600.60885242
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60705244
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58782393
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.57209963
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56625533
68Other glycan degradation_Homo sapiens_hsa005110.55656179
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53998782
70Bladder cancer_Homo sapiens_hsa052190.53812558
71ErbB signaling pathway_Homo sapiens_hsa040120.52980276
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52398408
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.51814914
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.51390522
75Apoptosis_Homo sapiens_hsa042100.50698750
76Adherens junction_Homo sapiens_hsa045200.50247147
77TNF signaling pathway_Homo sapiens_hsa046680.50085639
78Basal cell carcinoma_Homo sapiens_hsa052170.49722952
79Pyruvate metabolism_Homo sapiens_hsa006200.49456254
80Folate biosynthesis_Homo sapiens_hsa007900.48383898
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47946764
82Prolactin signaling pathway_Homo sapiens_hsa049170.47292721
83Measles_Homo sapiens_hsa051620.45691995
84Chronic myeloid leukemia_Homo sapiens_hsa052200.45434522
85AMPK signaling pathway_Homo sapiens_hsa041520.43336264
86Sulfur relay system_Homo sapiens_hsa041220.42989377
87Colorectal cancer_Homo sapiens_hsa052100.41791421
88Notch signaling pathway_Homo sapiens_hsa043300.41121113
89Acute myeloid leukemia_Homo sapiens_hsa052210.40849963
90Prion diseases_Homo sapiens_hsa050200.40541696
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40226010
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.39809678
93Shigellosis_Homo sapiens_hsa051310.39513105
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39217595
95HIF-1 signaling pathway_Homo sapiens_hsa040660.37965595
96Glutathione metabolism_Homo sapiens_hsa004800.37202603
97Pathways in cancer_Homo sapiens_hsa052000.37113417
98Insulin resistance_Homo sapiens_hsa049310.36331772
99Hepatitis B_Homo sapiens_hsa051610.35952623
100Prostate cancer_Homo sapiens_hsa052150.35855100
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34468175
102Carbon metabolism_Homo sapiens_hsa012000.34022405
103mTOR signaling pathway_Homo sapiens_hsa041500.31256769
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30343613
105Primary immunodeficiency_Homo sapiens_hsa053400.29746129
106Hedgehog signaling pathway_Homo sapiens_hsa043400.28370741
107Viral myocarditis_Homo sapiens_hsa054160.27927307
108Melanoma_Homo sapiens_hsa052180.26502831
109Proteoglycans in cancer_Homo sapiens_hsa052050.25545178
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24478658
111Influenza A_Homo sapiens_hsa051640.23719703
112Wnt signaling pathway_Homo sapiens_hsa043100.23241016
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22934744
114Hematopoietic cell lineage_Homo sapiens_hsa046400.22038436
115Tight junction_Homo sapiens_hsa045300.22012576
116Fructose and mannose metabolism_Homo sapiens_hsa000510.21461714
117Huntingtons disease_Homo sapiens_hsa050160.18387478
118Lysine degradation_Homo sapiens_hsa003100.17934431
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.17379216
120ECM-receptor interaction_Homo sapiens_hsa045120.15741268
121Galactose metabolism_Homo sapiens_hsa000520.14542714
122Protein export_Homo sapiens_hsa030600.13407935
123Pancreatic cancer_Homo sapiens_hsa052120.13021590
124FoxO signaling pathway_Homo sapiens_hsa040680.11049351
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10805393
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10713043
127Leishmaniasis_Homo sapiens_hsa051400.10467356
128Toxoplasmosis_Homo sapiens_hsa051450.10273380
129T cell receptor signaling pathway_Homo sapiens_hsa046600.09540737

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