NOP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.60131340
2maturation of SSU-rRNA (GO:0030490)5.27058707
3DNA deamination (GO:0045006)5.23984952
4proteasome assembly (GO:0043248)4.77597520
5ribosomal small subunit biogenesis (GO:0042274)4.76799807
6chaperone-mediated protein transport (GO:0072321)4.69495357
7nucleobase biosynthetic process (GO:0046112)4.54034268
8viral transcription (GO:0019083)4.50061628
9ribosomal large subunit biogenesis (GO:0042273)4.49575139
10translational termination (GO:0006415)4.45430000
11ribonucleoprotein complex biogenesis (GO:0022613)4.43652198
12formation of translation preinitiation complex (GO:0001731)4.41384366
13purine nucleobase biosynthetic process (GO:0009113)4.37460382
14DNA strand elongation involved in DNA replication (GO:0006271)4.36738216
15telomere maintenance via semi-conservative replication (GO:0032201)4.34166302
16ribosome biogenesis (GO:0042254)4.32694921
17DNA strand elongation (GO:0022616)4.16858759
18pseudouridine synthesis (GO:0001522)4.08436203
19regulation of mitochondrial translation (GO:0070129)4.04494601
20translational elongation (GO:0006414)4.03773059
21termination of RNA polymerase III transcription (GO:0006386)4.02820893
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.02820893
23rRNA modification (GO:0000154)4.01923298
24spliceosomal snRNP assembly (GO:0000387)4.01800274
25protein targeting to mitochondrion (GO:0006626)4.01628404
26rRNA processing (GO:0006364)4.00738468
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98320445
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96528673
29DNA replication checkpoint (GO:0000076)3.96293498
30CENP-A containing nucleosome assembly (GO:0034080)3.95173620
31translational initiation (GO:0006413)3.93773629
32DNA replication initiation (GO:0006270)3.93668484
33transcription from mitochondrial promoter (GO:0006390)3.90463122
34cotranslational protein targeting to membrane (GO:0006613)3.90384527
35telomere maintenance via recombination (GO:0000722)3.86919507
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86019653
37ATP synthesis coupled proton transport (GO:0015986)3.86019653
38rRNA metabolic process (GO:0016072)3.85800454
39protein targeting to ER (GO:0045047)3.85687563
40chromatin remodeling at centromere (GO:0031055)3.81375032
41ribosome assembly (GO:0042255)3.79710108
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76281250
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75267271
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72618230
45cellular component biogenesis (GO:0044085)3.70626280
46IMP biosynthetic process (GO:0006188)3.68571827
47protein localization to endoplasmic reticulum (GO:0070972)3.68109399
48mitotic metaphase plate congression (GO:0007080)3.67082111
49establishment of protein localization to mitochondrion (GO:0072655)3.65867117
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65481142
51negative regulation of ligase activity (GO:0051352)3.65481142
52protein localization to mitochondrion (GO:0070585)3.64452755
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63849407
54translation (GO:0006412)3.61823737
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60935847
56regulation of ubiquitin-protein transferase activity (GO:0051438)3.60670355
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55676271
58cellular protein complex disassembly (GO:0043624)3.54279900
597-methylguanosine mRNA capping (GO:0006370)3.53982443
60mitotic recombination (GO:0006312)3.53455904
617-methylguanosine RNA capping (GO:0009452)3.52154790
62RNA capping (GO:0036260)3.52154790
63mitochondrial RNA metabolic process (GO:0000959)3.51719805
64viral life cycle (GO:0019058)3.51241639
65establishment of integrated proviral latency (GO:0075713)3.51208264
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50108813
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50108813
68regulation of ligase activity (GO:0051340)3.50062128
69regulation of cellular amino acid metabolic process (GO:0006521)3.49575760
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48898339
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48898339
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48898339
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.47849661
74maturation of 5.8S rRNA (GO:0000460)3.46985794
75telomere maintenance via telomere lengthening (GO:0010833)3.46447652
76cullin deneddylation (GO:0010388)3.45209644
77transcription-coupled nucleotide-excision repair (GO:0006283)3.42099571
78mitochondrial respiratory chain complex assembly (GO:0033108)3.41897716
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41159446
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41083548
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40901326
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.40901326
83respiratory chain complex IV assembly (GO:0008535)3.40690990
84protein complex biogenesis (GO:0070271)3.37129218
85establishment of viral latency (GO:0019043)3.36754023
86spliceosomal complex assembly (GO:0000245)3.36340389
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35891879
88signal transduction involved in cell cycle checkpoint (GO:0072395)3.35341020
89kinetochore assembly (GO:0051382)3.34698025
90respiratory electron transport chain (GO:0022904)3.34675502
91tRNA aminoacylation for protein translation (GO:0006418)3.34147066
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33146528
93protein deneddylation (GO:0000338)3.32800837
94kinetochore organization (GO:0051383)3.32018778
95amino acid activation (GO:0043038)3.31675068
96tRNA aminoacylation (GO:0043039)3.31675068
97transcription elongation from RNA polymerase I promoter (GO:0006362)3.31254684
98transcription from RNA polymerase I promoter (GO:0006360)3.30927598
99folic acid-containing compound biosynthetic process (GO:0009396)3.30456728
100termination of RNA polymerase I transcription (GO:0006363)3.28842665
101DNA replication-independent nucleosome organization (GO:0034724)3.28614523
102DNA replication-independent nucleosome assembly (GO:0006336)3.28614523
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27753880
104electron transport chain (GO:0022900)3.27209360
105regulation of cellular amine metabolic process (GO:0033238)3.26620720
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26003150
107IMP metabolic process (GO:0046040)3.24338939
108DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.24230410
109peptidyl-histidine modification (GO:0018202)3.24090298
110positive regulation of cell cycle arrest (GO:0071158)3.23050851
111rRNA methylation (GO:0031167)3.23008331
112DNA unwinding involved in DNA replication (GO:0006268)3.22908292
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.22854611
114viral mRNA export from host cell nucleus (GO:0046784)3.20836488
115negative regulation of protein ubiquitination (GO:0031397)3.20832886
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20772161
117mitochondrial respiratory chain complex I assembly (GO:0032981)3.20772161
118NADH dehydrogenase complex assembly (GO:0010257)3.20772161
119inner mitochondrial membrane organization (GO:0007007)3.17515150
120G1/S transition of mitotic cell cycle (GO:0000082)3.16963055
121cell cycle G1/S phase transition (GO:0044843)3.16963055
122positive regulation of ligase activity (GO:0051351)3.16399921
123DNA catabolic process, exonucleolytic (GO:0000738)3.15293486
124oxidative phosphorylation (GO:0006119)3.14193839
125metaphase plate congression (GO:0051310)3.13991258
126cytochrome complex assembly (GO:0017004)3.11886399
127DNA damage response, detection of DNA damage (GO:0042769)3.11839253
128ncRNA processing (GO:0034470)3.10805566
129protein complex disassembly (GO:0043241)3.09627378
130histone exchange (GO:0043486)3.09542834
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08721992
132pteridine-containing compound biosynthetic process (GO:0042559)3.06872930
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05893127
134ncRNA metabolic process (GO:0034660)3.05416339
135protein localization to kinetochore (GO:0034501)3.04830323
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04711641
137tRNA metabolic process (GO:0006399)3.04686386
138antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02738974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51099318
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.76875013
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21379670
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00491022
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.88414414
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.85859736
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66763059
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.45968736
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26108476
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.22976052
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15570599
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13519380
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09647035
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07958309
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00759913
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77222772
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73956017
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73120289
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61044816
20VDR_23849224_ChIP-Seq_CD4+_Human2.58667150
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54900704
22XRN2_22483619_ChIP-Seq_HELA_Human2.48785458
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.40226826
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40139009
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36020890
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28199551
27* SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27384521
28DCP1A_22483619_ChIP-Seq_HELA_Human2.26148243
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.23161840
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18440140
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.09661387
32GABP_19822575_ChIP-Seq_HepG2_Human2.07162363
33TTF2_22483619_ChIP-Seq_HELA_Human2.03991955
34ELK1_19687146_ChIP-ChIP_HELA_Human2.01013665
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96780871
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95342354
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.92966868
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89627754
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84379189
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84354520
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77200681
42AR_21909140_ChIP-Seq_LNCAP_Human1.74929094
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74187814
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72119706
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68653243
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68075056
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65579108
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63819761
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58388722
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.57655383
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55726968
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.55501965
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54672208
54CIITA_25753668_ChIP-Seq_RAJI_Human1.47535673
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46680655
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42616607
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35641514
58KDM5A_27292631_Chip-Seq_BREAST_Human1.35076155
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.31408920
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30447041
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23352215
62MYC_18940864_ChIP-ChIP_HL60_Human1.21442319
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18198304
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17281953
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16926214
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16018124
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15249969
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14460997
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09685091
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05684836
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04503383
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04390563
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04340680
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.03259181
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01860366
76SPI1_23547873_ChIP-Seq_NB4_Human0.96755595
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96176589
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94234112
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94063728
80TFEB_21752829_ChIP-Seq_HELA_Human0.93856803
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93783112
82KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93116832
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92961867
84ZNF263_19887448_ChIP-Seq_K562_Human0.92886622
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92867148
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90810775
87ELF5_23300383_ChIP-Seq_T47D_Human0.89685551
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87344669
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84766302
90IRF1_19129219_ChIP-ChIP_H3396_Human0.82035363
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81964162
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81496582
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79938383
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79354971
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78850002
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77860066
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76564676
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76146202
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73890602
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73792831
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.73198495
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.73005313
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69887839
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69570942
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.68835916
106MYC_22102868_ChIP-Seq_BL_Human0.68648250
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68320429
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67879005
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67755025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69113267
2MP0004957_abnormal_blastocyst_morpholog4.61564612
3MP0010094_abnormal_chromosome_stability4.26838683
4MP0008057_abnormal_DNA_replication4.20584760
5MP0003111_abnormal_nucleus_morphology4.12072478
6MP0008058_abnormal_DNA_repair3.96109792
7MP0003077_abnormal_cell_cycle3.85690019
8MP0008007_abnormal_cellular_replicative3.03687695
9MP0008932_abnormal_embryonic_tissue2.73271153
10MP0002396_abnormal_hematopoietic_system2.70446165
11MP0003786_premature_aging2.54451937
12MP0009379_abnormal_foot_pigmentation2.48244172
13MP0003123_paternal_imprinting2.43859529
14MP0003806_abnormal_nucleotide_metabolis2.40607730
15MP0003718_maternal_effect2.25136331
16MP0003186_abnormal_redox_activity2.12595397
17MP0001730_embryonic_growth_arrest1.91482799
18MP0000350_abnormal_cell_proliferation1.86863778
19MP0008877_abnormal_DNA_methylation1.85720831
20MP0002132_abnormal_respiratory_system1.78532720
21MP0000490_abnormal_crypts_of1.73410549
22MP0006292_abnormal_olfactory_placode1.60443741
23MP0006036_abnormal_mitochondrial_physio1.56602144
24MP0009333_abnormal_splenocyte_physiolog1.56599082
25MP0001853_heart_inflammation1.54308020
26MP0000313_abnormal_cell_death1.49012053
27MP0006035_abnormal_mitochondrial_morpho1.47308150
28MP0003315_abnormal_perineum_morphology1.43953390
29MP0009697_abnormal_copulation1.39047061
30MP0005075_abnormal_melanosome_morpholog1.38893147
31MP0001697_abnormal_embryo_size1.34287047
32MP0003950_abnormal_plasma_membrane1.31476651
33MP0002019_abnormal_tumor_incidence1.29209787
34MP0002080_prenatal_lethality1.28100918
35MP0001764_abnormal_homeostasis1.26289666
36MP0003763_abnormal_thymus_physiology1.21059442
37MP0001672_abnormal_embryogenesis/_devel1.20727283
38MP0005380_embryogenesis_phenotype1.20727283
39MP0001529_abnormal_vocalization1.20717731
40MP0004147_increased_porphyrin_level1.20615975
41MP0004808_abnormal_hematopoietic_stem1.20527253
42MP0006072_abnormal_retinal_apoptosis1.19825655
43MP0003567_abnormal_fetal_cardiomyocyte1.11160019
44MP0002210_abnormal_sex_determination1.10805609
45MP0002160_abnormal_reproductive_system1.10688267
46MP0000689_abnormal_spleen_morphology1.10365169
47MP0001986_abnormal_taste_sensitivity1.08307720
48MP0003984_embryonic_growth_retardation1.07324329
49MP0002722_abnormal_immune_system1.06220842
50MP0005397_hematopoietic_system_phenotyp1.05389966
51MP0001545_abnormal_hematopoietic_system1.05389966
52MP0001881_abnormal_mammary_gland1.04756021
53MP0002398_abnormal_bone_marrow1.04245614
54MP0000358_abnormal_cell_content/1.03867711
55MP0002088_abnormal_embryonic_growth/wei1.02828303
56MP0010030_abnormal_orbit_morphology1.02485076
57MP0002938_white_spotting1.01721914
58MP0001873_stomach_inflammation1.01584526
59MP0005501_abnormal_skin_physiology1.00038459
60MP0008872_abnormal_physiological_respon1.00018093
61MP0003646_muscle_fatigue0.97468610
62MP0001145_abnormal_male_reproductive0.96977825
63MP0002085_abnormal_embryonic_tissue0.96608854
64MP0001835_abnormal_antigen_presentation0.96254737
65MP0005395_other_phenotype0.94111166
66MP0000703_abnormal_thymus_morphology0.93503252
67MP0005671_abnormal_response_to0.92108825
68MP0008875_abnormal_xenobiotic_pharmacok0.91796069
69MP0008995_early_reproductive_senescence0.90920091
70MP0002837_dystrophic_cardiac_calcinosis0.90627193
71MP0005330_cardiomyopathy0.90489055
72MP0002429_abnormal_blood_cell0.89111003
73MP0002095_abnormal_skin_pigmentation0.87004021
74MP0005389_reproductive_system_phenotype0.86700814
75MP0001119_abnormal_female_reproductive0.86565640
76MP0003941_abnormal_skin_development0.85421322
77MP0010307_abnormal_tumor_latency0.85419087
78MP0000749_muscle_degeneration0.85146621
79MP0001293_anophthalmia0.85096158
80MP0000015_abnormal_ear_pigmentation0.84941787
81MP0002006_tumorigenesis0.84738850
82MP0003121_genomic_imprinting0.84349494
83MP0000653_abnormal_sex_gland0.83733159
84MP0001929_abnormal_gametogenesis0.82553682
85MP0000372_irregular_coat_pigmentation0.81773095
86MP0005379_endocrine/exocrine_gland_phen0.81545172
87MP0002796_impaired_skin_barrier0.80798963
88MP0002086_abnormal_extraembryonic_tissu0.79702213
89MP0001188_hyperpigmentation0.78421907
90MP0001661_extended_life_span0.77722499
91MP0005332_abnormal_amino_acid0.77691232
92MP0002163_abnormal_gland_morphology0.76703490
93MP0000858_altered_metastatic_potential0.76204953
94MP0002736_abnormal_nociception_after0.74934714
95MP0004233_abnormal_muscle_weight0.74576272
96MP0000716_abnormal_immune_system0.74020541
97MP0004133_heterotaxia0.73605305
98MP0009785_altered_susceptibility_to0.73389437
99MP0004197_abnormal_fetal_growth/weight/0.73276724
100MP0005174_abnormal_tail_pigmentation0.73256769
101MP0008873_increased_physiological_sensi0.72838565
102MP0003656_abnormal_erythrocyte_physiolo0.72622428
103MP0006054_spinal_hemorrhage0.70925807
104MP0002084_abnormal_developmental_patter0.70644232
105MP0005636_abnormal_mineral_homeostasis0.69979697
106MP0003136_yellow_coat_color0.69479933
107MP0008789_abnormal_olfactory_epithelium0.69449088
108MP0005670_abnormal_white_adipose0.68525872
109MP0002102_abnormal_ear_morphology0.68171259
110MP0005266_abnormal_metabolism0.67179647
111MP0003011_delayed_dark_adaptation0.65360942
112MP0002148_abnormal_hypersensitivity_rea0.65089234
113MP0005384_cellular_phenotype0.65038968
114MP0002254_reproductive_system_inflammat0.64818347
115MP0001727_abnormal_embryo_implantation0.63984471
116MP0002751_abnormal_autonomic_nervous0.63913168
117MP0001800_abnormal_humoral_immune0.63711810
118MP0009672_abnormal_birth_weight0.62688354
119MP0002420_abnormal_adaptive_immunity0.60936545
120MP0001819_abnormal_immune_cell0.59521976
121MP0005084_abnormal_gallbladder_morpholo0.59345564
122MP0005410_abnormal_fertilization0.59129777
123MP0002452_abnormal_antigen_presenting0.58562982
124MP0001542_abnormal_bone_strength0.58190575
125MP0002638_abnormal_pupillary_reflex0.57882576
126MP0005408_hypopigmentation0.57666757
127MP0003221_abnormal_cardiomyocyte_apopto0.57604547
128MP0000627_abnormal_mammary_gland0.56926726
129MP0005319_abnormal_enzyme/_coenzyme0.55723027
130MP0000647_abnormal_sebaceous_gland0.54641128
131MP0002166_altered_tumor_susceptibility0.53061932

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.05115905
2Birth length less than 3rd percentile (HP:0003561)4.92270397
3Abnormal number of erythroid precursors (HP:0012131)4.90228001
4Reticulocytopenia (HP:0001896)4.34770729
5Oral leukoplakia (HP:0002745)3.94336394
6Aplastic anemia (HP:0001915)3.93033781
7Cerebral edema (HP:0002181)3.72039450
8Breast hypoplasia (HP:0003187)3.63305401
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.54702046
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.54702046
11Macrocytic anemia (HP:0001972)3.50737642
12Cerebral hypomyelination (HP:0006808)3.35368093
13Mitochondrial inheritance (HP:0001427)3.34188743
14Carpal bone hypoplasia (HP:0001498)3.32643578
15Rough bone trabeculation (HP:0100670)3.28476778
16Acute necrotizing encephalopathy (HP:0006965)3.27212142
17Hepatocellular necrosis (HP:0001404)3.24128522
18Abnormality of glycolysis (HP:0004366)3.22988397
19Increased serum pyruvate (HP:0003542)3.22988397
20Increased serum lactate (HP:0002151)3.21761285
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21100782
22Increased CSF lactate (HP:0002490)3.17381987
233-Methylglutaconic aciduria (HP:0003535)3.16180624
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15485850
25Pallor (HP:0000980)3.09232324
26Increased hepatocellular lipid droplets (HP:0006565)3.02962239
27Abnormal mitochondria in muscle tissue (HP:0008316)2.94938060
28Degeneration of anterior horn cells (HP:0002398)2.94763383
29Abnormality of the anterior horn cell (HP:0006802)2.94763383
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92175658
31Hepatic necrosis (HP:0002605)2.88424679
32Type I transferrin isoform profile (HP:0003642)2.87270653
33Microretrognathia (HP:0000308)2.81590989
34Chromsome breakage (HP:0040012)2.72122868
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.64832314
36Testicular atrophy (HP:0000029)2.63818444
37Abnormality of the preputium (HP:0100587)2.63591006
38Irregular epiphyses (HP:0010582)2.63050198
39Acute encephalopathy (HP:0006846)2.60483449
40Premature graying of hair (HP:0002216)2.60214523
41Patellar aplasia (HP:0006443)2.59739370
42Lipid accumulation in hepatocytes (HP:0006561)2.59551616
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59341479
44Exertional dyspnea (HP:0002875)2.57132411
45Progressive muscle weakness (HP:0003323)2.54041004
46Microvesicular hepatic steatosis (HP:0001414)2.52033208
47Lethargy (HP:0001254)2.49323089
48Leukodystrophy (HP:0002415)2.49183937
49Exercise intolerance (HP:0003546)2.47988558
50Increased muscle lipid content (HP:0009058)2.47237772
51Abnormal lung lobation (HP:0002101)2.47211489
52Meckel diverticulum (HP:0002245)2.47061329
53Progressive macrocephaly (HP:0004481)2.45833379
5411 pairs of ribs (HP:0000878)2.45648837
55Selective tooth agenesis (HP:0001592)2.45553732
56Aplasia/Hypoplasia of the patella (HP:0006498)2.45506950
57Amniotic constriction ring (HP:0009775)2.42407564
58Abnormality of placental membranes (HP:0011409)2.42407564
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41911950
60Type 2 muscle fiber atrophy (HP:0003554)2.40367390
61Absent thumb (HP:0009777)2.40345846
62Methylmalonic aciduria (HP:0012120)2.39763138
63Abnormal trabecular bone morphology (HP:0100671)2.39136763
64Lactic acidosis (HP:0003128)2.37985494
65Multiple enchondromatosis (HP:0005701)2.37864623
66Thrombocytosis (HP:0001894)2.37607467
67Pancytopenia (HP:0001876)2.37225383
68Abnormality of methionine metabolism (HP:0010901)2.37088029
69Secondary amenorrhea (HP:0000869)2.36983525
70Abnormality of the ileum (HP:0001549)2.35174336
71Renal Fanconi syndrome (HP:0001994)2.30386744
72Reduced antithrombin III activity (HP:0001976)2.29436021
73Colon cancer (HP:0003003)2.29348916
74Muscle fiber atrophy (HP:0100295)2.27649956
75Myelodysplasia (HP:0002863)2.26184750
76Respiratory difficulties (HP:0002880)2.25415011
77Glossoptosis (HP:0000162)2.23152823
78Cellular immunodeficiency (HP:0005374)2.23124435
79Bone marrow hypocellularity (HP:0005528)2.22649450
80Trismus (HP:0000211)2.22425145
81Abnormality of chromosome stability (HP:0003220)2.21228615
82Optic disc pallor (HP:0000543)2.21157562
83Abnormality of serum amino acid levels (HP:0003112)2.20601621
84Sparse eyelashes (HP:0000653)2.19320670
85CNS demyelination (HP:0007305)2.17878334
86Increased intramyocellular lipid droplets (HP:0012240)2.13111796
87Methylmalonic acidemia (HP:0002912)2.12708282
88IgM deficiency (HP:0002850)2.11136502
89Cleft eyelid (HP:0000625)2.09304589
90CNS hypomyelination (HP:0003429)2.09127343
91Abnormal number of incisors (HP:0011064)2.04644130
92Poor head control (HP:0002421)2.04469729
93Ragged-red muscle fibers (HP:0003200)2.02392187
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.01862261
95Horseshoe kidney (HP:0000085)2.01581348
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00704879
97Absent radius (HP:0003974)2.00251933
98Supernumerary spleens (HP:0009799)1.99323543
99Premature ovarian failure (HP:0008209)1.98966829
100Respiratory failure (HP:0002878)1.97591115
101Triphalangeal thumb (HP:0001199)1.96935687
102Small intestinal stenosis (HP:0012848)1.96449456
103Duodenal stenosis (HP:0100867)1.96449456
104Abnormality of alanine metabolism (HP:0010916)1.95480859
105Hyperalaninemia (HP:0003348)1.95480859
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95480859
107Ependymoma (HP:0002888)1.93963210
108Pulmonary fibrosis (HP:0002206)1.93046817
109Abnormal protein glycosylation (HP:0012346)1.92950895
110Abnormal glycosylation (HP:0012345)1.92950895
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92950895
112Abnormal protein N-linked glycosylation (HP:0012347)1.92950895
113Palpitations (HP:0001962)1.91306948
114Generalized aminoaciduria (HP:0002909)1.91104768
115Abnormal spermatogenesis (HP:0008669)1.91048970
116Impulsivity (HP:0100710)1.89625330
117Abnormality of the labia minora (HP:0012880)1.86721714
118Cholecystitis (HP:0001082)1.86572970
119Abnormal gallbladder physiology (HP:0012438)1.86572970
120Aplasia involving forearm bones (HP:0009822)1.84900233
121Absent forearm bone (HP:0003953)1.84900233
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84115896
123Dicarboxylic aciduria (HP:0003215)1.84115896
124Nausea (HP:0002018)1.83996947
125Emotional lability (HP:0000712)1.83540574
126Progressive microcephaly (HP:0000253)1.80982648
127Facial cleft (HP:0002006)1.77655070
128Abnormalities of placenta or umbilical cord (HP:0001194)1.77333664
129Sensory axonal neuropathy (HP:0003390)1.76641704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.58112834
2VRK24.51762692
3WEE14.11561501
4EIF2AK14.04595834
5STK163.50665793
6NME23.18332793
7EIF2AK33.03290852
8SRPK12.94037312
9CDC72.84080152
10TSSK62.60878150
11VRK12.44150271
12PDK22.32676554
13BRSK22.25410571
14MKNK12.22638579
15PLK42.20500448
16NUAK12.03268868
17PIM22.02332144
18NME11.74578619
19MKNK21.72720022
20ACVR1B1.71911133
21PLK11.65975790
22PBK1.59089894
23TLK11.58120117
24PLK31.53225784
25TESK21.52720874
26TRIM281.48849202
27CCNB11.47652963
28AURKB1.42419802
29TAF11.39019026
30TTK1.39017309
31RPS6KA41.36018070
32CDK71.33141133
33MAP4K21.29959261
34ATR1.29584641
35ZAK1.29457248
36BRSK11.29267207
37NEK21.28330911
38IRAK31.25343576
39CDK81.22782519
40DYRK31.22205216
41EIF2AK21.18392542
42KDR1.17409703
43AURKA1.15837766
44RPS6KB21.11774074
45NEK11.10364252
46TGFBR11.09223983
47CHEK20.95609611
48MAP3K110.95424946
49PASK0.92400562
50MST40.89848746
51IRAK40.88920692
52BCKDK0.86108488
53MAP4K10.84742947
54PIM10.84093129
55SMG10.83610866
56CSNK2A10.83251046
57MST1R0.81871869
58CSNK2A20.79127007
59CHEK10.75074662
60PNCK0.73957871
61MAP3K80.73199166
62ALK0.72564380
63ABL20.68018989
64CDK40.67310814
65TXK0.66882453
66SCYL20.66705105
67BRAF0.64639403
68DYRK20.59811097
69STK40.59798876
70EPHA20.59017022
71CSNK1G10.58674668
72PAK10.58090730
73RPS6KA50.57952177
74TESK10.57511052
75PAK40.57116443
76TEC0.57066836
77MAP2K30.57065369
78ATM0.55090887
79IKBKB0.54406272
80CLK10.54046001
81MUSK0.52301864
82BLK0.52257862
83MAP3K120.51396409
84LIMK10.51316623
85TAOK20.51299057
86NEK90.50243911
87CDK20.48580552
88CSNK1A1L0.48566652
89ARAF0.47167468
90ERBB30.46233979
91ADRBK20.44843793
92PRKCI0.43701468
93STK390.43699487
94MYLK0.43372707
95CSNK1G20.43195149
96DAPK10.42700585
97ERBB40.41236693
98KIT0.39366357
99MAPKAPK30.39294924
100YES10.38418130
101CDK10.36317090
102BTK0.35533644
103LYN0.34257983
104ILK0.33830609
105FLT30.32453014
106CSNK1G30.31985908
107ZAP700.31632904
108MELK0.31623863
109DAPK30.31157737
110STK100.31140152
111MAP3K30.30569723
112STK240.30060702
113PLK20.28837787
114CSNK1E0.27801852
115WNK40.27021045
116BMPR1B0.25648063
117LRRK20.24365638
118MAPKAPK50.23674763
119GRK50.22732589
120STK38L0.22424803
121AKT20.22413341
122STK30.22037448
123WNK30.21470299
124OXSR10.21111878
125RAF10.21079929
126CDK190.20941304
127CSNK1A10.19746640

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.47457008
2Proteasome_Homo sapiens_hsa030504.47036667
3DNA replication_Homo sapiens_hsa030304.31152178
4RNA polymerase_Homo sapiens_hsa030204.04117286
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77522272
6Mismatch repair_Homo sapiens_hsa034303.64674817
7Spliceosome_Homo sapiens_hsa030403.03715415
8Homologous recombination_Homo sapiens_hsa034402.83920855
9Pyrimidine metabolism_Homo sapiens_hsa002402.83593222
10RNA transport_Homo sapiens_hsa030132.73228145
11Base excision repair_Homo sapiens_hsa034102.68540956
12Nucleotide excision repair_Homo sapiens_hsa034202.68030283
13One carbon pool by folate_Homo sapiens_hsa006702.19062380
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17115353
15Basal transcription factors_Homo sapiens_hsa030221.94490900
16Cell cycle_Homo sapiens_hsa041101.91895781
17Fanconi anemia pathway_Homo sapiens_hsa034601.89241947
18Oxidative phosphorylation_Homo sapiens_hsa001901.88721331
19Parkinsons disease_Homo sapiens_hsa050121.85501331
20RNA degradation_Homo sapiens_hsa030181.83093604
21Non-homologous end-joining_Homo sapiens_hsa034501.78077889
22Protein export_Homo sapiens_hsa030601.73879981
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65709925
24Purine metabolism_Homo sapiens_hsa002301.58289273
25Huntingtons disease_Homo sapiens_hsa050161.55871684
26mRNA surveillance pathway_Homo sapiens_hsa030151.18177590
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11980695
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11866499
29Epstein-Barr virus infection_Homo sapiens_hsa051691.11068181
30Propanoate metabolism_Homo sapiens_hsa006401.10189449
31p53 signaling pathway_Homo sapiens_hsa041151.09946044
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.08362852
33Sulfur metabolism_Homo sapiens_hsa009201.02511843
34Alzheimers disease_Homo sapiens_hsa050100.99568124
35Folate biosynthesis_Homo sapiens_hsa007900.99108704
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96591482
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95642234
38Pentose phosphate pathway_Homo sapiens_hsa000300.92791340
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86964582
40Vitamin B6 metabolism_Homo sapiens_hsa007500.86039620
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.82864067
42Glutathione metabolism_Homo sapiens_hsa004800.82082417
43Sulfur relay system_Homo sapiens_hsa041220.78917205
44Biosynthesis of amino acids_Homo sapiens_hsa012300.75998518
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.73172535
46Steroid biosynthesis_Homo sapiens_hsa001000.72746613
47Herpes simplex infection_Homo sapiens_hsa051680.69520439
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69135523
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65365070
50Antigen processing and presentation_Homo sapiens_hsa046120.64340455
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64048490
52Systemic lupus erythematosus_Homo sapiens_hsa053220.62551022
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60196326
54Selenocompound metabolism_Homo sapiens_hsa004500.59722171
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57176824
56Metabolic pathways_Homo sapiens_hsa011000.56503518
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54738669
58Arachidonic acid metabolism_Homo sapiens_hsa005900.54243036
59Fructose and mannose metabolism_Homo sapiens_hsa000510.52899033
60Carbon metabolism_Homo sapiens_hsa012000.51834597
61Peroxisome_Homo sapiens_hsa041460.50554428
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50464966
63Legionellosis_Homo sapiens_hsa051340.49081442
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46950964
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46609868
66Oocyte meiosis_Homo sapiens_hsa041140.45665838
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44710251
68Primary immunodeficiency_Homo sapiens_hsa053400.44395067
69Viral carcinogenesis_Homo sapiens_hsa052030.42985914
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42205470
71Galactose metabolism_Homo sapiens_hsa000520.39274121
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38888599
73N-Glycan biosynthesis_Homo sapiens_hsa005100.38770844
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36325622
75Fatty acid metabolism_Homo sapiens_hsa012120.34731675
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34587451
77Allograft rejection_Homo sapiens_hsa053300.33022086
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30165444
79HTLV-I infection_Homo sapiens_hsa051660.29015491
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27457051
81Thyroid cancer_Homo sapiens_hsa052160.26972759
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26886134
83Collecting duct acid secretion_Homo sapiens_hsa049660.26054920
84Arginine and proline metabolism_Homo sapiens_hsa003300.26038993
85Measles_Homo sapiens_hsa051620.25249955
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24692076
87Cardiac muscle contraction_Homo sapiens_hsa042600.24196101
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23368597
89beta-Alanine metabolism_Homo sapiens_hsa004100.22812713
90Apoptosis_Homo sapiens_hsa042100.22734350
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.21880601
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.19022897
93Tryptophan metabolism_Homo sapiens_hsa003800.18681644
94Hematopoietic cell lineage_Homo sapiens_hsa046400.18414905
95Shigellosis_Homo sapiens_hsa051310.18015789
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17975452
97Autoimmune thyroid disease_Homo sapiens_hsa053200.17739757
98Asthma_Homo sapiens_hsa053100.17635974
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17318002
100Pyruvate metabolism_Homo sapiens_hsa006200.15647232
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15585206
102Tyrosine metabolism_Homo sapiens_hsa003500.15250490
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15240669
104Fatty acid elongation_Homo sapiens_hsa000620.14581596
105Regulation of autophagy_Homo sapiens_hsa041400.14462180
106Fatty acid degradation_Homo sapiens_hsa000710.14094391
107Phenylalanine metabolism_Homo sapiens_hsa003600.14061077
108Caffeine metabolism_Homo sapiens_hsa002320.12665654
109Butanoate metabolism_Homo sapiens_hsa006500.11916429
110Other glycan degradation_Homo sapiens_hsa005110.10499976
111Rheumatoid arthritis_Homo sapiens_hsa053230.10262021
112Influenza A_Homo sapiens_hsa051640.10182767
113Type I diabetes mellitus_Homo sapiens_hsa049400.10040993
114Graft-versus-host disease_Homo sapiens_hsa053320.09536493
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.07911543
116Linoleic acid metabolism_Homo sapiens_hsa005910.07615309
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07350409
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07214046
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05113878
120Vitamin digestion and absorption_Homo sapiens_hsa049770.04631164
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.03757289
122Alcoholism_Homo sapiens_hsa050340.03614171

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