

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nucleobase biosynthetic process (GO:0046112) | 5.02335160 |
| 2 | DNA unwinding involved in DNA replication (GO:0006268) | 4.89850463 |
| 3 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.69143747 |
| 4 | IMP biosynthetic process (GO:0006188) | 4.66318363 |
| 5 | DNA replication initiation (GO:0006270) | 4.63547369 |
| 6 | nuclear pore organization (GO:0006999) | 4.62617981 |
| 7 | purine nucleobase biosynthetic process (GO:0009113) | 4.60061107 |
| 8 | formation of translation preinitiation complex (GO:0001731) | 4.58362856 |
| 9 | protein localization to kinetochore (GO:0034501) | 4.55052611 |
| 10 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.48153088 |
| 11 | nuclear pore complex assembly (GO:0051292) | 4.43367831 |
| 12 | mitotic nuclear envelope disassembly (GO:0007077) | 4.40295469 |
| 13 | ribosome assembly (GO:0042255) | 4.28851954 |
| 14 | ribosome biogenesis (GO:0042254) | 4.26929081 |
| 15 | DNA strand elongation (GO:0022616) | 4.25083482 |
| 16 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.22132868 |
| 17 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.22132868 |
| 18 | maturation of SSU-rRNA (GO:0030490) | 4.15719815 |
| 19 | IMP metabolic process (GO:0046040) | 4.09577713 |
| 20 | membrane disassembly (GO:0030397) | 4.08921978 |
| 21 | nuclear envelope disassembly (GO:0051081) | 4.08921978 |
| 22 | mitotic metaphase plate congression (GO:0007080) | 4.04737953 |
| 23 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 4.04016855 |
| 24 | DNA replication checkpoint (GO:0000076) | 3.96775710 |
| 25 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.89477109 |
| 26 | protein localization to chromosome, centromeric region (GO:0071459) | 3.76516753 |
| 27 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.76096441 |
| 28 | negative regulation of mRNA processing (GO:0050686) | 3.61664694 |
| 29 | folic acid metabolic process (GO:0046655) | 3.56707410 |
| 30 | DNA duplex unwinding (GO:0032508) | 3.55632497 |
| 31 | establishment of integrated proviral latency (GO:0075713) | 3.53663786 |
| 32 | DNA geometric change (GO:0032392) | 3.53101119 |
| 33 | viral mRNA export from host cell nucleus (GO:0046784) | 3.52731973 |
| 34 | ribosomal large subunit biogenesis (GO:0042273) | 3.50342010 |
| 35 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.50159542 |
| 36 | mitotic sister chromatid segregation (GO:0000070) | 3.49999524 |
| 37 | regulation of spindle organization (GO:0090224) | 3.46989674 |
| 38 | pore complex assembly (GO:0046931) | 3.46775475 |
| 39 | metaphase plate congression (GO:0051310) | 3.45646034 |
| 40 | ribosomal small subunit assembly (GO:0000028) | 3.45039830 |
| 41 | telomere maintenance via recombination (GO:0000722) | 3.42886902 |
| 42 | tRNA methylation (GO:0030488) | 3.40551065 |
| 43 | * rRNA processing (GO:0006364) | 3.40228608 |
| 44 | regulation of translational termination (GO:0006449) | 3.38112839 |
| 45 | regulation of translational fidelity (GO:0006450) | 3.37752444 |
| 46 | negative regulation of mRNA metabolic process (GO:1903312) | 3.35660610 |
| 47 | rRNA transcription (GO:0009303) | 3.34739266 |
| 48 | mitotic recombination (GO:0006312) | 3.30354211 |
| 49 | mitochondrial RNA metabolic process (GO:0000959) | 3.30234646 |
| 50 | translational initiation (GO:0006413) | 3.29228495 |
| 51 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.29087774 |
| 52 | * rRNA metabolic process (GO:0016072) | 3.29046972 |
| 53 | telomere maintenance via telomere lengthening (GO:0010833) | 3.25935356 |
| 54 | regulation of gene silencing by RNA (GO:0060966) | 3.25497429 |
| 55 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.25497429 |
| 56 | regulation of gene silencing by miRNA (GO:0060964) | 3.25497429 |
| 57 | spliceosomal snRNP assembly (GO:0000387) | 3.25036148 |
| 58 | DNA deamination (GO:0045006) | 3.23386327 |
| 59 | viral transcription (GO:0019083) | 3.22307976 |
| 60 | translational termination (GO:0006415) | 3.22266296 |
| 61 | transcription from mitochondrial promoter (GO:0006390) | 3.22215449 |
| 62 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.21823112 |
| 63 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.21823112 |
| 64 | mitotic chromosome condensation (GO:0007076) | 3.21820030 |
| 65 | nuclear envelope organization (GO:0006998) | 3.19667563 |
| 66 | sister chromatid segregation (GO:0000819) | 3.19509975 |
| 67 | Golgi transport vesicle coating (GO:0048200) | 3.17188519 |
| 68 | COPI coating of Golgi vesicle (GO:0048205) | 3.17188519 |
| 69 | positive regulation of chromosome segregation (GO:0051984) | 3.15176863 |
| 70 | chromatin remodeling at centromere (GO:0031055) | 3.14926143 |
| 71 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.14078148 |
| 72 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.12124238 |
| 73 | heterochromatin organization (GO:0070828) | 3.11932395 |
| 74 | CENP-A containing nucleosome assembly (GO:0034080) | 3.10749653 |
| 75 | pseudouridine synthesis (GO:0001522) | 3.10487193 |
| 76 | translational elongation (GO:0006414) | 3.10314319 |
| 77 | protein complex localization (GO:0031503) | 3.09021910 |
| 78 | DNA topological change (GO:0006265) | 3.08363743 |
| 79 | regulation of mitochondrial translation (GO:0070129) | 3.07389032 |
| 80 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.06382305 |
| 81 | DNA replication-independent nucleosome organization (GO:0034724) | 3.06382305 |
| 82 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.04219628 |
| 83 | regulation of mitotic spindle organization (GO:0060236) | 3.03608365 |
| 84 | establishment of chromosome localization (GO:0051303) | 3.03086118 |
| 85 | chromosome condensation (GO:0030261) | 3.02903246 |
| 86 | rRNA methylation (GO:0031167) | 3.01044341 |
| 87 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.00959040 |
| 88 | mitotic sister chromatid cohesion (GO:0007064) | 2.99590329 |
| 89 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.97315063 |
| 90 | ribosomal small subunit biogenesis (GO:0042274) | 2.97005641 |
| 91 | maturation of 5.8S rRNA (GO:0000460) | 2.96668720 |
| 92 | tRNA aminoacylation for protein translation (GO:0006418) | 2.94604472 |
| 93 | proline biosynthetic process (GO:0006561) | 2.93871092 |
| 94 | rRNA modification (GO:0000154) | 2.92198517 |
| 95 | regulation of centrosome cycle (GO:0046605) | 2.91021766 |
| 96 | cellular protein complex localization (GO:0034629) | 2.90245335 |
| 97 | chromatin assembly or disassembly (GO:0006333) | 2.88864880 |
| 98 | kinetochore organization (GO:0051383) | 2.87799218 |
| 99 | establishment of viral latency (GO:0019043) | 2.87745822 |
| 100 | regulation of histone H3-K9 methylation (GO:0051570) | 2.85372000 |
| 101 | tRNA aminoacylation (GO:0043039) | 2.84563903 |
| 102 | amino acid activation (GO:0043038) | 2.84563903 |
| 103 | termination of RNA polymerase II transcription (GO:0006369) | 2.84466306 |
| 104 | DNA conformation change (GO:0071103) | 2.84204430 |
| 105 | histone arginine methylation (GO:0034969) | 2.82400635 |
| 106 | negative regulation of chromosome segregation (GO:0051985) | 2.82295135 |
| 107 | ncRNA 3-end processing (GO:0043628) | 2.81833998 |
| 108 | negative regulation of RNA splicing (GO:0033119) | 2.80719145 |
| 109 | tetrahydrofolate metabolic process (GO:0046653) | 2.80659075 |
| 110 | regulation of chromosome segregation (GO:0051983) | 2.80026197 |
| 111 | mRNA export from nucleus (GO:0006406) | 2.79907746 |
| 112 | peptidyl-arginine N-methylation (GO:0035246) | 2.79793612 |
| 113 | peptidyl-arginine methylation (GO:0018216) | 2.79793612 |
| 114 | RNA splicing, via transesterification reactions (GO:0000375) | 2.79663466 |
| 115 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.79255742 |
| 116 | regulation of translation in response to stress (GO:0043555) | 2.78798243 |
| 117 | mRNA splicing, via spliceosome (GO:0000398) | 2.78774717 |
| 118 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.78774717 |
| 119 | regulation of translational elongation (GO:0006448) | 2.78359311 |
| 120 | RNA export from nucleus (GO:0006405) | 2.76137265 |
| 121 | regulation of RNA export from nucleus (GO:0046831) | 2.75883120 |
| 122 | mRNA transport (GO:0051028) | 2.75659756 |
| 123 | cell cycle G1/S phase transition (GO:0044843) | 2.75040391 |
| 124 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.75040391 |
| 125 | negative regulation of histone methylation (GO:0031061) | 2.74815488 |
| 126 | dosage compensation (GO:0007549) | 2.74505970 |
| 127 | DNA synthesis involved in DNA repair (GO:0000731) | 2.73499077 |
| 128 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.73235278 |
| 129 | negative regulation of sister chromatid segregation (GO:0033046) | 2.73235278 |
| 130 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.73235278 |
| 131 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.73235278 |
| 132 | DNA packaging (GO:0006323) | 2.72431242 |
| 133 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.72271564 |
| 134 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.71214036 |
| 135 | cellular component biogenesis (GO:0044085) | 2.71152122 |
| 136 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.67913763 |
| 137 | protein export from nucleus (GO:0006611) | 2.67881945 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.39013834 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.35626687 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.80938092 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.73363227 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.36331082 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.16517959 |
| 7 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.82943354 |
| 8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.80979459 |
| 9 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.75119346 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.54776179 |
| 11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.53530306 |
| 12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.42365150 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.41632122 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35979143 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.32158009 |
| 16 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.29334487 |
| 17 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.27597794 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.27346856 |
| 19 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.12483250 |
| 20 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.05441731 |
| 21 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.00915189 |
| 22 | MYC_22102868_ChIP-Seq_BL_Human | 2.00466334 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.94558806 |
| 24 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.92895823 |
| 25 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.89897911 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88469261 |
| 27 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.87475071 |
| 28 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.87192859 |
| 29 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.86536903 |
| 30 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.85919857 |
| 31 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84222816 |
| 32 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.81808174 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.76419629 |
| 34 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.75310701 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.73256591 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.73010259 |
| 37 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.72759247 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.66571530 |
| 39 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.63961871 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.62897217 |
| 41 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.60428703 |
| 42 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.58003688 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.55210755 |
| 44 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.54439951 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.52823483 |
| 46 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.51913404 |
| 47 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49377187 |
| 48 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.48475986 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.45630734 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.39958708 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.35294894 |
| 52 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.34005348 |
| 53 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.33814067 |
| 54 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.31955137 |
| 55 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.31521136 |
| 56 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30144644 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27054038 |
| 58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.24438275 |
| 59 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.23731211 |
| 60 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.22955141 |
| 61 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.22882388 |
| 62 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.22287669 |
| 63 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.20930597 |
| 64 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.18189366 |
| 65 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18163533 |
| 66 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.15004695 |
| 67 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.14877872 |
| 68 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.14594793 |
| 69 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.12347419 |
| 70 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.10400405 |
| 71 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10315993 |
| 72 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.09943456 |
| 73 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.09786689 |
| 74 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.06820257 |
| 75 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.06225226 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06077326 |
| 77 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.05941022 |
| 78 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.05235143 |
| 79 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.05017872 |
| 80 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.04192024 |
| 81 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.04192024 |
| 82 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.04192024 |
| 83 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.03910095 |
| 84 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.03859723 |
| 85 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.03437525 |
| 86 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03397653 |
| 87 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02789340 |
| 88 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02522103 |
| 89 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02503597 |
| 90 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.02373707 |
| 91 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.01904134 |
| 92 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.00964691 |
| 93 | MAF_26560356_Chip-Seq_TH2_Human | 1.00727350 |
| 94 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99458407 |
| 95 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.98735062 |
| 96 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.97873290 |
| 97 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.97632902 |
| 98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97371160 |
| 99 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.97002718 |
| 100 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.96919998 |
| 101 | MAF_26560356_Chip-Seq_TH1_Human | 0.96047822 |
| 102 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.95803586 |
| 103 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95771344 |
| 104 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.95617121 |
| 105 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.94428457 |
| 106 | ATF3_27146783_Chip-Seq_COLON_Human | 0.93580809 |
| 107 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93480925 |
| 108 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.92569975 |
| 109 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.91413139 |
| 110 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.91203491 |
| 111 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.91020060 |
| 112 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.90807358 |
| 113 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.89792476 |
| 114 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.89226834 |
| 115 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.88634282 |
| 116 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.88186879 |
| 117 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84905980 |
| 118 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.84037231 |
| 119 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.83906971 |
| 120 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.83829765 |
| 121 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.83655392 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.08679493 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.39991829 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.39621455 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.33567169 |
| 5 | MP0003077_abnormal_cell_cycle | 3.87073474 |
| 6 | MP0008057_abnormal_DNA_replication | 3.84088361 |
| 7 | MP0010352_gastrointestinal_tract_polyps | 3.04463508 |
| 8 | MP0008058_abnormal_DNA_repair | 2.92914547 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.81642324 |
| 10 | MP0001730_embryonic_growth_arrest | 2.65330807 |
| 11 | MP0002396_abnormal_hematopoietic_system | 2.53374427 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.50264907 |
| 13 | MP0002877_abnormal_melanocyte_morpholog | 2.45401299 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.42220815 |
| 15 | MP0005451_abnormal_body_composition | 2.41194599 |
| 16 | MP0010307_abnormal_tumor_latency | 2.31233922 |
| 17 | MP0003123_paternal_imprinting | 2.30704174 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 2.02019922 |
| 19 | MP0005380_embryogenesis_phenotype | 2.02019922 |
| 20 | MP0003806_abnormal_nucleotide_metabolis | 1.91459541 |
| 21 | MP0001697_abnormal_embryo_size | 1.88960543 |
| 22 | MP0003786_premature_aging | 1.87925952 |
| 23 | MP0003984_embryonic_growth_retardation | 1.85700140 |
| 24 | MP0002088_abnormal_embryonic_growth/wei | 1.81692503 |
| 25 | MP0002080_prenatal_lethality | 1.78663544 |
| 26 | MP0000490_abnormal_crypts_of | 1.70273811 |
| 27 | MP0003705_abnormal_hypodermis_morpholog | 1.70201979 |
| 28 | MP0002086_abnormal_extraembryonic_tissu | 1.68873790 |
| 29 | MP0002085_abnormal_embryonic_tissue | 1.67671917 |
| 30 | MP0002084_abnormal_developmental_patter | 1.66418121 |
| 31 | MP0004197_abnormal_fetal_growth/weight/ | 1.65411515 |
| 32 | MP0004185_abnormal_adipocyte_glucose | 1.64724117 |
| 33 | MP0008260_abnormal_autophagy | 1.63432683 |
| 34 | MP0005076_abnormal_cell_differentiation | 1.62231641 |
| 35 | MP0006035_abnormal_mitochondrial_morpho | 1.56615681 |
| 36 | MP0004808_abnormal_hematopoietic_stem | 1.52488120 |
| 37 | MP0000313_abnormal_cell_death | 1.47747313 |
| 38 | MP0001873_stomach_inflammation | 1.46374626 |
| 39 | MP0002019_abnormal_tumor_incidence | 1.43568938 |
| 40 | MP0001661_extended_life_span | 1.39920397 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.39647712 |
| 42 | MP0008877_abnormal_DNA_methylation | 1.37388204 |
| 43 | MP0003718_maternal_effect | 1.35778546 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.32558061 |
| 45 | MP0001348_abnormal_lacrimal_gland | 1.28335959 |
| 46 | MP0003890_abnormal_embryonic-extraembry | 1.26627576 |
| 47 | MP0005397_hematopoietic_system_phenotyp | 1.26313105 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.26313105 |
| 49 | MP0002796_impaired_skin_barrier | 1.23971592 |
| 50 | MP0005023_abnormal_wound_healing | 1.23627489 |
| 51 | MP0003566_abnormal_cell_adhesion | 1.23615803 |
| 52 | MP0010030_abnormal_orbit_morphology | 1.20463337 |
| 53 | MP0001293_anophthalmia | 1.19193422 |
| 54 | MP0000537_abnormal_urethra_morphology | 1.09474721 |
| 55 | MP0000703_abnormal_thymus_morphology | 1.05138866 |
| 56 | MP0000358_abnormal_cell_content/ | 1.04586471 |
| 57 | MP0000678_abnormal_parathyroid_gland | 1.02831753 |
| 58 | MP0002060_abnormal_skin_morphology | 1.02576035 |
| 59 | MP0003453_abnormal_keratinocyte_physiol | 1.01429232 |
| 60 | MP0003763_abnormal_thymus_physiology | 1.00961812 |
| 61 | MP0003119_abnormal_digestive_system | 0.99761049 |
| 62 | MP0002722_abnormal_immune_system | 0.99187529 |
| 63 | MP0003121_genomic_imprinting | 0.98005039 |
| 64 | MP0006036_abnormal_mitochondrial_physio | 0.96880650 |
| 65 | MP0010234_abnormal_vibrissa_follicle | 0.95945220 |
| 66 | MP0009278_abnormal_bone_marrow | 0.95891440 |
| 67 | MP0002653_abnormal_ependyma_morphology | 0.95547203 |
| 68 | MP0000689_abnormal_spleen_morphology | 0.95378686 |
| 69 | MP0005058_abnormal_lysosome_morphology | 0.95077774 |
| 70 | MP0002398_abnormal_bone_marrow | 0.94763058 |
| 71 | MP0009053_abnormal_anal_canal | 0.94291574 |
| 72 | MP0000750_abnormal_muscle_regeneration | 0.93834817 |
| 73 | MP0000858_altered_metastatic_potential | 0.93652963 |
| 74 | MP0004133_heterotaxia | 0.93002937 |
| 75 | MP0001216_abnormal_epidermal_layer | 0.92346696 |
| 76 | MP0002111_abnormal_tail_morphology | 0.91553557 |
| 77 | MP0001915_intracranial_hemorrhage | 0.91403397 |
| 78 | MP0003221_abnormal_cardiomyocyte_apopto | 0.90976977 |
| 79 | MP0002210_abnormal_sex_determination | 0.90087415 |
| 80 | MP0002166_altered_tumor_susceptibility | 0.89818872 |
| 81 | MP0000685_abnormal_immune_system | 0.87941675 |
| 82 | MP0005384_cellular_phenotype | 0.87649843 |
| 83 | MP0009672_abnormal_birth_weight | 0.87341351 |
| 84 | MP0001145_abnormal_male_reproductive | 0.86595823 |
| 85 | MP0005621_abnormal_cell_physiology | 0.86555563 |
| 86 | MP0002006_tumorigenesis | 0.85708017 |
| 87 | MP0001849_ear_inflammation | 0.81795517 |
| 88 | MP0004264_abnormal_extraembryonic_tissu | 0.81181633 |
| 89 | MP0003436_decreased_susceptibility_to | 0.80901966 |
| 90 | MP0006054_spinal_hemorrhage | 0.79658669 |
| 91 | MP0002009_preneoplasia | 0.78026851 |
| 92 | MP0000003_abnormal_adipose_tissue | 0.77145960 |
| 93 | MP0000428_abnormal_craniofacial_morphol | 0.76697419 |
| 94 | MP0000579_abnormal_nail_morphology | 0.75546145 |
| 95 | MP0000733_abnormal_muscle_development | 0.75506335 |
| 96 | MP0002429_abnormal_blood_cell | 0.75347968 |
| 97 | MP0001346_abnormal_lacrimal_gland | 0.74087933 |
| 98 | MP0004381_abnormal_hair_follicle | 0.73397083 |
| 99 | MP0000467_abnormal_esophagus_morphology | 0.73065593 |
| 100 | MP0002092_abnormal_eye_morphology | 0.72743944 |
| 101 | MP0000477_abnormal_intestine_morphology | 0.70970100 |
| 102 | MP0003943_abnormal_hepatobiliary_system | 0.68311409 |
| 103 | MP0004233_abnormal_muscle_weight | 0.68301897 |
| 104 | MP0009840_abnormal_foam_cell | 0.68114373 |
| 105 | MP0001853_heart_inflammation | 0.67668897 |
| 106 | MP0001835_abnormal_antigen_presentation | 0.67564271 |
| 107 | MP0008770_decreased_survivor_rate | 0.67377899 |
| 108 | MP0009703_decreased_birth_body | 0.67333547 |
| 109 | MP0009931_abnormal_skin_appearance | 0.67243132 |
| 110 | MP0000653_abnormal_sex_gland | 0.67058110 |
| 111 | MP0005310_abnormal_salivary_gland | 0.67048862 |
| 112 | MP0001727_abnormal_embryo_implantation | 0.66999672 |
| 113 | MP0002970_abnormal_white_adipose | 0.65572161 |
| 114 | MP0004947_skin_inflammation | 0.65111865 |
| 115 | MP0002269_muscular_atrophy | 0.64736576 |
| 116 | MP0001929_abnormal_gametogenesis | 0.64704489 |
| 117 | MP0004858_abnormal_nervous_system | 0.64700393 |
| 118 | MP0002089_abnormal_postnatal_growth/wei | 0.64217195 |
| 119 | MP0003941_abnormal_skin_development | 0.64213462 |
| 120 | MP0005266_abnormal_metabolism | 0.64087764 |
| 121 | MP0002160_abnormal_reproductive_system | 0.63194591 |
| 122 | MP0001881_abnormal_mammary_gland | 0.61638081 |
| 123 | MP0003315_abnormal_perineum_morphology | 0.60121200 |
| 124 | MP0000627_abnormal_mammary_gland | 0.59784109 |
| 125 | MP0002925_abnormal_cardiovascular_devel | 0.59386590 |
| 126 | MP0002405_respiratory_system_inflammati | 0.58363914 |
| 127 | MP0005501_abnormal_skin_physiology | 0.58283163 |
| 128 | MP0003699_abnormal_female_reproductive | 0.58124012 |
| 129 | MP0002132_abnormal_respiratory_system | 0.57813186 |
| 130 | MP0003186_abnormal_redox_activity | 0.57532962 |
| 131 | MP0004782_abnormal_surfactant_physiolog | 0.57311256 |
| 132 | MP0000716_abnormal_immune_system | 0.57275482 |
| 133 | MP0003937_abnormal_limbs/digits/tail_de | 0.56542144 |
| 134 | MP0002697_abnormal_eye_size | 0.56437217 |
| 135 | MP0001119_abnormal_female_reproductive | 0.54871048 |
| 136 | MP0000598_abnormal_liver_morphology | 0.54778870 |
| 137 | MP0000432_abnormal_head_morphology | 0.53290318 |
| 138 | MP0000371_diluted_coat_color | 0.52345058 |
| 139 | MP0003448_altered_tumor_morphology | 0.51729921 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.74871020 |
| 2 | Microvesicular hepatic steatosis (HP:0001414) | 4.64133125 |
| 3 | Selective tooth agenesis (HP:0001592) | 4.05202438 |
| 4 | Ependymoma (HP:0002888) | 3.96688556 |
| 5 | Breast hypoplasia (HP:0003187) | 3.74033033 |
| 6 | Progressive external ophthalmoplegia (HP:0000590) | 3.45878775 |
| 7 | Reticulocytopenia (HP:0001896) | 3.43062542 |
| 8 | Degeneration of anterior horn cells (HP:0002398) | 3.39984490 |
| 9 | Abnormality of the anterior horn cell (HP:0006802) | 3.39984490 |
| 10 | Oral leukoplakia (HP:0002745) | 3.34102370 |
| 11 | Medulloblastoma (HP:0002885) | 3.31439473 |
| 12 | Ragged-red muscle fibers (HP:0003200) | 3.23713861 |
| 13 | Colon cancer (HP:0003003) | 3.19805227 |
| 14 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.12975919 |
| 15 | Chromsome breakage (HP:0040012) | 3.09880621 |
| 16 | Agnosia (HP:0010524) | 3.06655298 |
| 17 | Rough bone trabeculation (HP:0100670) | 3.05977662 |
| 18 | Patellar aplasia (HP:0006443) | 3.00912803 |
| 19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.95887972 |
| 20 | Abnormal number of erythroid precursors (HP:0012131) | 2.94511933 |
| 21 | Hyperacusis (HP:0010780) | 2.91924361 |
| 22 | Carpal bone hypoplasia (HP:0001498) | 2.86307895 |
| 23 | Rhabdomyosarcoma (HP:0002859) | 2.85255670 |
| 24 | Cerebral hypomyelination (HP:0006808) | 2.84732421 |
| 25 | Abnormality of the labia minora (HP:0012880) | 2.83004002 |
| 26 | Multiple enchondromatosis (HP:0005701) | 2.82398119 |
| 27 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.81811112 |
| 28 | Abnormality of glycolysis (HP:0004366) | 2.81220645 |
| 29 | Trismus (HP:0000211) | 2.75412981 |
| 30 | Abnormality of chromosome stability (HP:0003220) | 2.72567187 |
| 31 | Poikiloderma (HP:0001029) | 2.70964845 |
| 32 | Impulsivity (HP:0100710) | 2.69133075 |
| 33 | Astrocytoma (HP:0009592) | 2.66804703 |
| 34 | Abnormality of the astrocytes (HP:0100707) | 2.66804703 |
| 35 | Meckel diverticulum (HP:0002245) | 2.63865418 |
| 36 | Basal cell carcinoma (HP:0002671) | 2.59451829 |
| 37 | Abnormality of the preputium (HP:0100587) | 2.58118198 |
| 38 | Neoplasm of the pancreas (HP:0002894) | 2.56187150 |
| 39 | Abnormality of the ileum (HP:0001549) | 2.55889539 |
| 40 | Absent thumb (HP:0009777) | 2.55655953 |
| 41 | Absent radius (HP:0003974) | 2.55395556 |
| 42 | Testicular atrophy (HP:0000029) | 2.51015369 |
| 43 | Myelodysplasia (HP:0002863) | 2.47840006 |
| 44 | Deviation of the thumb (HP:0009603) | 2.45911544 |
| 45 | Premature ovarian failure (HP:0008209) | 2.41156496 |
| 46 | Proximal placement of thumb (HP:0009623) | 2.40951927 |
| 47 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.40600856 |
| 48 | Increased serum pyruvate (HP:0003542) | 2.37739487 |
| 49 | Premature graying of hair (HP:0002216) | 2.37709293 |
| 50 | Aplastic anemia (HP:0001915) | 2.35839479 |
| 51 | Glioma (HP:0009733) | 2.34696254 |
| 52 | Aplasia involving forearm bones (HP:0009822) | 2.34617314 |
| 53 | Absent forearm bone (HP:0003953) | 2.34617314 |
| 54 | Squamous cell carcinoma (HP:0002860) | 2.34617085 |
| 55 | Missing ribs (HP:0000921) | 2.33585623 |
| 56 | 11 pairs of ribs (HP:0000878) | 2.32207573 |
| 57 | Microretrognathia (HP:0000308) | 2.30736065 |
| 58 | Entropion (HP:0000621) | 2.30285917 |
| 59 | Abnormality of the calcaneus (HP:0008364) | 2.29604613 |
| 60 | Macrocytic anemia (HP:0001972) | 2.27978350 |
| 61 | Abnormal gallbladder physiology (HP:0012438) | 2.26775793 |
| 62 | Cholecystitis (HP:0001082) | 2.26775793 |
| 63 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.26650927 |
| 64 | Septate vagina (HP:0001153) | 2.25478943 |
| 65 | Abnormal trabecular bone morphology (HP:0100671) | 2.23234917 |
| 66 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.22792416 |
| 67 | Abnormal number of incisors (HP:0011064) | 2.21172423 |
| 68 | Fatigue (HP:0012378) | 2.16976060 |
| 69 | Small intestinal stenosis (HP:0012848) | 2.16275190 |
| 70 | Duodenal stenosis (HP:0100867) | 2.16275190 |
| 71 | Neoplasm of striated muscle (HP:0009728) | 2.16032888 |
| 72 | Pallor (HP:0000980) | 2.15815841 |
| 73 | Slender long bone (HP:0003100) | 2.14417561 |
| 74 | Bone marrow hypocellularity (HP:0005528) | 2.14171981 |
| 75 | Thrombocytosis (HP:0001894) | 2.13002222 |
| 76 | Amaurosis fugax (HP:0100576) | 2.12595012 |
| 77 | Atresia of the external auditory canal (HP:0000413) | 2.12277435 |
| 78 | Neoplasm of the oral cavity (HP:0100649) | 2.07970059 |
| 79 | Tracheoesophageal fistula (HP:0002575) | 2.07031685 |
| 80 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.06231653 |
| 81 | Spinal muscular atrophy (HP:0007269) | 2.05919554 |
| 82 | Long palpebral fissure (HP:0000637) | 2.05682367 |
| 83 | Prominent nose (HP:0000448) | 2.05008652 |
| 84 | Glossoptosis (HP:0000162) | 2.03337590 |
| 85 | Sparse eyelashes (HP:0000653) | 2.03203564 |
| 86 | Sloping forehead (HP:0000340) | 2.02858729 |
| 87 | Cafe-au-lait spot (HP:0000957) | 2.01848437 |
| 88 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.00162190 |
| 89 | Achilles tendon contracture (HP:0001771) | 1.99817695 |
| 90 | Short humerus (HP:0005792) | 1.99629222 |
| 91 | Cellular immunodeficiency (HP:0005374) | 1.98316416 |
| 92 | Progressive muscle weakness (HP:0003323) | 1.97157226 |
| 93 | Secondary amenorrhea (HP:0000869) | 1.96904176 |
| 94 | Insomnia (HP:0100785) | 1.94894647 |
| 95 | Ureteral duplication (HP:0000073) | 1.92519740 |
| 96 | Overlapping toe (HP:0001845) | 1.91571737 |
| 97 | Horseshoe kidney (HP:0000085) | 1.91428457 |
| 98 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.89850722 |
| 99 | Increased nuchal translucency (HP:0010880) | 1.89498902 |
| 100 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.88614266 |
| 101 | Sparse lateral eyebrow (HP:0005338) | 1.87377363 |
| 102 | Megaloblastic anemia (HP:0001889) | 1.87211217 |
| 103 | High pitched voice (HP:0001620) | 1.86938073 |
| 104 | Supernumerary spleens (HP:0009799) | 1.86826682 |
| 105 | Elfin facies (HP:0004428) | 1.86594071 |
| 106 | Upper limb muscle weakness (HP:0003484) | 1.86427474 |
| 107 | Angiofibromas (HP:0010615) | 1.86290369 |
| 108 | Adenoma sebaceum (HP:0009720) | 1.86290369 |
| 109 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.86267407 |
| 110 | Personality changes (HP:0000751) | 1.86189156 |
| 111 | Biliary tract neoplasm (HP:0100574) | 1.86017159 |
| 112 | IgA deficiency (HP:0002720) | 1.84819212 |
| 113 | Hypergonadotropic hypogonadism (HP:0000815) | 1.83844633 |
| 114 | Increased serum lactate (HP:0002151) | 1.83522465 |
| 115 | Urethral obstruction (HP:0000796) | 1.83508560 |
| 116 | Ectopic kidney (HP:0000086) | 1.82974993 |
| 117 | Pancytopenia (HP:0001876) | 1.82915068 |
| 118 | Preauricular skin tag (HP:0000384) | 1.82109266 |
| 119 | Abnormality of the duodenum (HP:0002246) | 1.81499165 |
| 120 | Tongue fasciculations (HP:0001308) | 1.80744295 |
| 121 | Progressive hearing impairment (HP:0001730) | 1.79907305 |
| 122 | Abnormality of DNA repair (HP:0003254) | 1.79833320 |
| 123 | Abnormality of reticulocytes (HP:0004312) | 1.79284693 |
| 124 | Cutaneous melanoma (HP:0012056) | 1.78061559 |
| 125 | Lymphoma (HP:0002665) | 1.77215297 |
| 126 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.76406139 |
| 127 | Impaired proprioception (HP:0010831) | 1.75962024 |
| 128 | Abnormality of the umbilical cord (HP:0010881) | 1.75306144 |
| 129 | Facial hemangioma (HP:0000329) | 1.74683571 |
| 130 | Ankle contracture (HP:0006466) | 1.74494627 |
| 131 | Muscle fibrillation (HP:0010546) | 1.74359945 |
| 132 | Spastic diplegia (HP:0001264) | 1.74020354 |
| 133 | Pelvic girdle muscle weakness (HP:0003749) | 1.72431952 |
| 134 | Deep palmar crease (HP:0006191) | 1.71813330 |
| 135 | Abnormality of the carotid arteries (HP:0005344) | 1.68623670 |
| 136 | Recurrent viral infections (HP:0004429) | 1.68103362 |
| 137 | Abnormality of the Achilles tendon (HP:0005109) | 1.67441280 |
| 138 | High anterior hairline (HP:0009890) | 1.66952329 |
| 139 | Hypertensive crisis (HP:0100735) | 1.66061294 |
| 140 | Ulnar bowing (HP:0003031) | 1.64956985 |
| 141 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.64531947 |
| 142 | Short thumb (HP:0009778) | 1.64059231 |
| 143 | Choanal atresia (HP:0000453) | 1.63744288 |
| 144 | Hypoplasia of the pons (HP:0012110) | 1.63493537 |
| 145 | Cleft eyelid (HP:0000625) | 1.63042590 |
| 146 | Abnormality of cochlea (HP:0000375) | 1.62821936 |
| 147 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.61991326 |
| 148 | Overriding aorta (HP:0002623) | 1.61107873 |
| 149 | Broad distal phalanx of finger (HP:0009836) | 1.60397352 |
| 150 | Type I transferrin isoform profile (HP:0003642) | 1.60167447 |
| 151 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.60057818 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.17884377 |
| 2 | WEE1 | 4.15501333 |
| 3 | SMG1 | 3.74821769 |
| 4 | CDC7 | 3.72229702 |
| 5 | TSSK6 | 3.10975219 |
| 6 | EIF2AK1 | 2.71097704 |
| 7 | IRAK3 | 2.68402382 |
| 8 | NEK2 | 2.62492450 |
| 9 | VRK2 | 2.46118393 |
| 10 | EEF2K | 2.41495950 |
| 11 | NEK1 | 2.37817649 |
| 12 | CDK12 | 2.35766146 |
| 13 | TTK | 2.23899851 |
| 14 | EPHA2 | 2.11675244 |
| 15 | PBK | 2.10300549 |
| 16 | TESK2 | 1.95655087 |
| 17 | NME2 | 1.93338993 |
| 18 | RPS6KB2 | 1.93314173 |
| 19 | SRPK1 | 1.88166653 |
| 20 | PLK1 | 1.83929391 |
| 21 | CDK7 | 1.80462458 |
| 22 | ACVR1B | 1.78045438 |
| 23 | ICK | 1.73712473 |
| 24 | BRSK2 | 1.70197493 |
| 25 | PASK | 1.68401149 |
| 26 | STK10 | 1.67089329 |
| 27 | ATR | 1.60494309 |
| 28 | MAP3K8 | 1.57791382 |
| 29 | PKN2 | 1.57301883 |
| 30 | AURKB | 1.53837970 |
| 31 | EIF2AK3 | 1.53695523 |
| 32 | SCYL2 | 1.52538962 |
| 33 | MST1R | 1.52443852 |
| 34 | PRPF4B | 1.52419536 |
| 35 | NME1 | 1.52221973 |
| 36 | TLK1 | 1.46558021 |
| 37 | PLK4 | 1.45251468 |
| 38 | RPS6KA4 | 1.41552898 |
| 39 | CDK4 | 1.39874639 |
| 40 | MKNK1 | 1.38872444 |
| 41 | PLK3 | 1.36987503 |
| 42 | MAP3K10 | 1.35014354 |
| 43 | PAK4 | 1.32803250 |
| 44 | CHEK1 | 1.31515261 |
| 45 | TGFBR1 | 1.26369208 |
| 46 | ALK | 1.25395834 |
| 47 | VRK1 | 1.23620265 |
| 48 | SIK1 | 1.20794561 |
| 49 | CHEK2 | 1.20727021 |
| 50 | DYRK3 | 1.20260706 |
| 51 | AURKA | 1.18057585 |
| 52 | PIM2 | 1.09963221 |
| 53 | FLT3 | 1.03761804 |
| 54 | PIM1 | 1.02983795 |
| 55 | BRSK1 | 1.01136944 |
| 56 | LATS2 | 1.01072857 |
| 57 | MKNK2 | 0.95221811 |
| 58 | MAP2K3 | 0.94913388 |
| 59 | TRIB3 | 0.92924361 |
| 60 | MAP4K1 | 0.91967151 |
| 61 | SIK3 | 0.91931277 |
| 62 | LRRK2 | 0.91045737 |
| 63 | MAPK11 | 0.89531820 |
| 64 | CDK2 | 0.89427614 |
| 65 | STK16 | 0.88638108 |
| 66 | MAP3K11 | 0.83356431 |
| 67 | ATM | 0.82909401 |
| 68 | ZAK | 0.81620347 |
| 69 | PAK1 | 0.80694093 |
| 70 | FGFR4 | 0.80375469 |
| 71 | CDK9 | 0.79490385 |
| 72 | MTOR | 0.79447586 |
| 73 | STK4 | 0.77448762 |
| 74 | MAP3K14 | 0.76964809 |
| 75 | MAPKAPK3 | 0.75836403 |
| 76 | TESK1 | 0.75554289 |
| 77 | PAK2 | 0.73634886 |
| 78 | TRIM28 | 0.70766725 |
| 79 | BRAF | 0.70528334 |
| 80 | CSNK2A2 | 0.70469120 |
| 81 | TTN | 0.70462272 |
| 82 | PNCK | 0.70027266 |
| 83 | CLK1 | 0.67987834 |
| 84 | CDK6 | 0.66863528 |
| 85 | TAF1 | 0.65746649 |
| 86 | ARAF | 0.63531068 |
| 87 | STK3 | 0.62888302 |
| 88 | PDK3 | 0.62539088 |
| 89 | PDK4 | 0.62539088 |
| 90 | BRD4 | 0.62158581 |
| 91 | MAP3K13 | 0.60927990 |
| 92 | DAPK1 | 0.58147690 |
| 93 | CDK1 | 0.57564497 |
| 94 | PRKCI | 0.56462146 |
| 95 | IRAK2 | 0.56091483 |
| 96 | KDR | 0.55715577 |
| 97 | CSNK2A1 | 0.54921028 |
| 98 | AKT2 | 0.54239266 |
| 99 | ZAP70 | 0.54109402 |
| 100 | TAOK2 | 0.51352706 |
| 101 | IRAK4 | 0.51201546 |
| 102 | CCNB1 | 0.50914852 |
| 103 | MAP3K3 | 0.49204490 |
| 104 | GRK6 | 0.47915841 |
| 105 | MELK | 0.44999666 |
| 106 | CSNK1E | 0.44610683 |
| 107 | LATS1 | 0.43651085 |
| 108 | MET | 0.43036104 |
| 109 | RAF1 | 0.42270087 |
| 110 | CAMK1D | 0.41938409 |
| 111 | ERBB4 | 0.40944738 |
| 112 | FGFR1 | 0.39401357 |
| 113 | BMX | 0.39167985 |
| 114 | EIF2AK2 | 0.38595633 |
| 115 | MAPKAPK5 | 0.38159304 |
| 116 | SIK2 | 0.38107775 |
| 117 | AKT3 | 0.35581067 |
| 118 | CSF1R | 0.34505764 |
| 119 | RPS6KA5 | 0.33403773 |
| 120 | RPS6KA1 | 0.33246539 |
| 121 | PRKDC | 0.31817078 |
| 122 | PDK2 | 0.31427106 |
| 123 | STK38L | 0.30541289 |
| 124 | MAP3K5 | 0.29917309 |
| 125 | ILK | 0.29233682 |
| 126 | CDK8 | 0.27446853 |
| 127 | ERN1 | 0.27437736 |
| 128 | JAK3 | 0.26272586 |
| 129 | TAOK1 | 0.25666698 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.66367396 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.14591953 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.95397500 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.37816515 |
| 5 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.20329672 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.19348078 |
| 7 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 3.05322466 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.96063673 |
| 9 | Ribosome_Homo sapiens_hsa03010 | 2.83158601 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.79899947 |
| 11 | Proteasome_Homo sapiens_hsa03050 | 2.71756352 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67367101 |
| 13 | Cell cycle_Homo sapiens_hsa04110 | 2.62993339 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.51392134 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.17277997 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.88673640 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.78085471 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.70404628 |
| 19 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.70039317 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.69263270 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.55114071 |
| 22 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.44246296 |
| 23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.26847419 |
| 24 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.25916806 |
| 25 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.22831726 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19735302 |
| 27 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.17740748 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.16061149 |
| 29 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.15251842 |
| 30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.13631868 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.07765540 |
| 32 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.06810013 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.06342429 |
| 34 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.00235831 |
| 35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.95408449 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.91462315 |
| 37 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.90210196 |
| 38 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.86342495 |
| 39 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84004240 |
| 40 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.82094719 |
| 41 | HTLV-I infection_Homo sapiens_hsa05166 | 0.81113237 |
| 42 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79848657 |
| 43 | Legionellosis_Homo sapiens_hsa05134 | 0.77509748 |
| 44 | Sulfur relay system_Homo sapiens_hsa04122 | 0.76994704 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75860114 |
| 46 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.74859581 |
| 47 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.73741910 |
| 48 | Thyroid cancer_Homo sapiens_hsa05216 | 0.72361659 |
| 49 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.71920710 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.68443132 |
| 51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.67670778 |
| 52 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65685269 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.63397172 |
| 54 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.60537431 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.59220603 |
| 56 | Apoptosis_Homo sapiens_hsa04210 | 0.58090950 |
| 57 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.57847261 |
| 58 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.57061474 |
| 59 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.55202780 |
| 60 | Bladder cancer_Homo sapiens_hsa05219 | 0.54843389 |
| 61 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.49117827 |
| 62 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.47926570 |
| 63 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.47544434 |
| 64 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.46866614 |
| 65 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.46739502 |
| 66 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46065260 |
| 67 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.45929413 |
| 68 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.44608102 |
| 69 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.42086591 |
| 70 | Other glycan degradation_Homo sapiens_hsa00511 | 0.41298967 |
| 71 | Shigellosis_Homo sapiens_hsa05131 | 0.41152908 |
| 72 | Colorectal cancer_Homo sapiens_hsa05210 | 0.40750090 |
| 73 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.39885281 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39277466 |
| 75 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.39277090 |
| 76 | Galactose metabolism_Homo sapiens_hsa00052 | 0.37753358 |
| 77 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.37614947 |
| 78 | Hepatitis B_Homo sapiens_hsa05161 | 0.37557525 |
| 79 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.36515530 |
| 80 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.35948883 |
| 81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35807879 |
| 82 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.35448498 |
| 83 | Measles_Homo sapiens_hsa05162 | 0.35251991 |
| 84 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.34972840 |
| 85 | Viral myocarditis_Homo sapiens_hsa05416 | 0.32956404 |
| 86 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.32191563 |
| 87 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.30891194 |
| 88 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.30374239 |
| 89 | Alcoholism_Homo sapiens_hsa05034 | 0.30268631 |
| 90 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.28777586 |
| 91 | Endometrial cancer_Homo sapiens_hsa05213 | 0.28681167 |
| 92 | Huntingtons disease_Homo sapiens_hsa05016 | 0.28633609 |
| 93 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.28334616 |
| 94 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.27118477 |
| 95 | Adherens junction_Homo sapiens_hsa04520 | 0.26464412 |
| 96 | Protein export_Homo sapiens_hsa03060 | 0.25930298 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.25326041 |
| 98 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.24926630 |
| 99 | Hepatitis C_Homo sapiens_hsa05160 | 0.24615681 |
| 100 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.24218158 |
| 101 | Pathways in cancer_Homo sapiens_hsa05200 | 0.22738050 |
| 102 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.20647494 |
| 103 | Influenza A_Homo sapiens_hsa05164 | 0.20290474 |
| 104 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.19923935 |
| 105 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.19037378 |
| 106 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.18977369 |
| 107 | Lysine degradation_Homo sapiens_hsa00310 | 0.18903214 |
| 108 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.18091905 |
| 109 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.17759146 |
| 110 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.16757552 |
| 111 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.14519968 |
| 112 | Prostate cancer_Homo sapiens_hsa05215 | 0.14439439 |
| 113 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.14043503 |
| 114 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.13613477 |
| 115 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.12041851 |
| 116 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.11704053 |
| 117 | Metabolic pathways_Homo sapiens_hsa01100 | 0.09181156 |
| 118 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.08527020 |
| 119 | Tight junction_Homo sapiens_hsa04530 | 0.07764331 |
| 120 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.07332244 |

