NOP56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA damage checkpoint (GO:2000001)6.61155839
2cell wall macromolecule catabolic process (GO:0016998)6.00277461
3cell wall macromolecule metabolic process (GO:0044036)6.00277461
4negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.85493368
5regulation of somitogenesis (GO:0014807)4.47037222
6nuclear pore complex assembly (GO:0051292)4.46038616
7DNA replication initiation (GO:0006270)4.45924768
8DNA unwinding involved in DNA replication (GO:0006268)4.44027463
9protein localization to kinetochore (GO:0034501)4.41278173
10DNA replication-dependent nucleosome assembly (GO:0006335)4.38708342
11DNA replication-dependent nucleosome organization (GO:0034723)4.38708342
12nuclear pore organization (GO:0006999)4.38385681
13DNA strand elongation involved in DNA replication (GO:0006271)4.38103611
14negative regulation of mRNA processing (GO:0050686)4.29876276
15fusion of sperm to egg plasma membrane (GO:0007342)4.25165762
16nucleobase biosynthetic process (GO:0046112)4.24757141
17negative regulation of RNA splicing (GO:0033119)4.22910280
18sperm-egg recognition (GO:0035036)4.21857175
19DNA replication checkpoint (GO:0000076)4.21841510
20DNA strand elongation (GO:0022616)4.19119223
21ribosome biogenesis (GO:0042254)4.19082977
22protein prenylation (GO:0018342)4.18148010
23prenylation (GO:0097354)4.18148010
24maturation of SSU-rRNA (GO:0030490)4.08151613
25telomere maintenance via semi-conservative replication (GO:0032201)3.97870319
26positive regulation of RNA splicing (GO:0033120)3.96312353
27mitotic metaphase plate congression (GO:0007080)3.92487533
28purine nucleobase biosynthetic process (GO:0009113)3.92366716
29mitotic nuclear envelope disassembly (GO:0007077)3.91870076
30regulation of cell cycle checkpoint (GO:1901976)3.84123446
31formation of translation preinitiation complex (GO:0001731)3.79433371
32negative regulation of mRNA metabolic process (GO:1903312)3.79101107
33IMP biosynthetic process (GO:0006188)3.77149363
34cell-cell recognition (GO:0009988)3.76989816
35ribonucleoprotein complex biogenesis (GO:0022613)3.74596302
36acrosome assembly (GO:0001675)3.74264601
37chromatin remodeling at centromere (GO:0031055)3.73745879
38multicellular organism reproduction (GO:0032504)3.71599458
39CENP-A containing nucleosome assembly (GO:0034080)3.71334380
40protein localization to chromosome, centromeric region (GO:0071459)3.70662909
41binding of sperm to zona pellucida (GO:0007339)3.69818010
42telomere maintenance via recombination (GO:0000722)3.66119021
43ribosome assembly (GO:0042255)3.64720934
44histone exchange (GO:0043486)3.63155546
45ribosomal large subunit biogenesis (GO:0042273)3.61914340
46membrane disassembly (GO:0030397)3.61698061
47nuclear envelope disassembly (GO:0051081)3.61698061
48ribosomal small subunit assembly (GO:0000028)3.55778317
49spliceosomal snRNP assembly (GO:0000387)3.53354672
50viral transcription (GO:0019083)3.52085288
51translational termination (GO:0006415)3.51888178
52mitotic recombination (GO:0006312)3.51595033
53kinetochore organization (GO:0051383)3.50285542
54pore complex assembly (GO:0046931)3.47269495
55metaphase plate congression (GO:0051310)3.46196584
56negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.46166303
57DNA replication-independent nucleosome organization (GO:0034724)3.45443845
58DNA replication-independent nucleosome assembly (GO:0006336)3.45443845
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.43933806
60translational initiation (GO:0006413)3.41778193
61nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.39863070
62cilium or flagellum-dependent cell motility (GO:0001539)3.39566925
63telomere organization (GO:0032200)3.39073548
64IMP metabolic process (GO:0046040)3.38353950
65regulation of centriole replication (GO:0046599)3.37952611
66folic acid-containing compound biosynthetic process (GO:0009396)3.37928925
67telomere maintenance (GO:0000723)3.37167798
68DNA deamination (GO:0045006)3.35323225
69maturation of 5.8S rRNA (GO:0000460)3.32601361
70telomere maintenance via telomere lengthening (GO:0010833)3.32124049
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30925988
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.30925988
73* rRNA processing (GO:0006364)3.30503711
74DNA topological change (GO:0006265)3.29263484
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26712755
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26712755
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.26712755
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26434962
79protein K6-linked ubiquitination (GO:0085020)3.26339688
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.24848357
81microtubule depolymerization (GO:0007019)3.22604118
82mitotic sister chromatid segregation (GO:0000070)3.21743500
83protein complex localization (GO:0031503)3.21575381
84* rRNA metabolic process (GO:0016072)3.20863593
85kinetochore assembly (GO:0051382)3.19408407
86cellular protein complex localization (GO:0034629)3.19274500
87translational elongation (GO:0006414)3.19024730
88DNA geometric change (GO:0032392)3.16965616
89DNA duplex unwinding (GO:0032508)3.16905509
90regulation of centrosome cycle (GO:0046605)3.16474997
91replicative senescence (GO:0090399)3.15855001
92viral mRNA export from host cell nucleus (GO:0046784)3.14891961
93regulation of spindle organization (GO:0090224)3.13621080
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13114655
95negative regulation of DNA repair (GO:0045738)3.12996213
96regulation of DNA endoreduplication (GO:0032875)3.11074021
97termination of RNA polymerase I transcription (GO:0006363)3.10468555
98mitotic chromosome condensation (GO:0007076)3.10426007
99positive regulation of DNA-templated transcription, elongation (GO:0032786)3.10401016
100chromatin assembly or disassembly (GO:0006333)3.08613717
101histone-serine phosphorylation (GO:0035404)3.07242911
102plasma membrane fusion (GO:0045026)3.06247007
103mitotic sister chromatid cohesion (GO:0007064)3.05164299
104mRNA cleavage (GO:0006379)3.05040523
105telomere maintenance via telomerase (GO:0007004)3.04775407
106sister chromatid segregation (GO:0000819)3.02891232
107establishment of chromosome localization (GO:0051303)3.02309579
108regulation of chromosome segregation (GO:0051983)2.99818182
109termination of RNA polymerase II transcription (GO:0006369)2.96353335
110heterochromatin organization (GO:0070828)2.96085616
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95547783
112negative regulation of chromosome segregation (GO:0051985)2.93359624
113reproduction (GO:0000003)2.92561520
114ribosomal small subunit biogenesis (GO:0042274)2.92209588
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91666402
116negative regulation of sister chromatid segregation (GO:0033046)2.91666402
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.91666402
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91666402
119cellular protein complex disassembly (GO:0043624)2.90165227
120histone H2A acetylation (GO:0043968)2.88695523
121ATP-dependent chromatin remodeling (GO:0043044)2.88446461
122positive regulation of chromosome segregation (GO:0051984)2.87396428
123histone mRNA metabolic process (GO:0008334)2.87262832
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87060954
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86389250
126pseudouridine synthesis (GO:0001522)2.85679003
127chaperone-mediated protein complex assembly (GO:0051131)2.83624488
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82660941
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82473983
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.82465236
131attachment of spindle microtubules to kinetochore (GO:0008608)2.82241404
132transcription initiation from RNA polymerase I promoter (GO:0006361)2.81056534
133regulation of translational fidelity (GO:0006450)2.80883861
134transcription from RNA polymerase I promoter (GO:0006360)2.77804318
135cellular component biogenesis (GO:0044085)2.77499256
136regulation of histone H3-K9 methylation (GO:0051570)2.77104795
137transcription from mitochondrial promoter (GO:0006390)2.75603017
138spliceosomal complex assembly (GO:0000245)2.74273396
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.71857422
140mRNA splicing, via spliceosome (GO:0000398)2.70348151
141RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70348151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31726234
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.59153535
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10826010
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.98221011
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.85326174
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24983689
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18105340
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04812589
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96221807
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.92364119
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82547185
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73621991
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.64700993
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.63476043
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55656711
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47429464
17* XRN2_22483619_ChIP-Seq_HELA_Human2.39052653
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39021452
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38949196
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34997929
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31026724
22VDR_23849224_ChIP-Seq_CD4+_Human2.27242215
23AR_21909140_ChIP-Seq_LNCAP_Human2.09694958
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09653648
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.06899180
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06825094
27FOXP3_21729870_ChIP-Seq_TREG_Human2.04613110
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96957293
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96741855
30* TTF2_22483619_ChIP-Seq_HELA_Human1.92028469
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.89760337
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79906998
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78785924
34GABP_19822575_ChIP-Seq_HepG2_Human1.73835235
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73832255
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71806132
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71183979
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69289038
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67585259
40* DCP1A_22483619_ChIP-Seq_HELA_Human1.66104089
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65383705
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64089997
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63298245
44ELK1_19687146_ChIP-ChIP_HELA_Human1.61143372
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59977737
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.57541501
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56894585
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56484396
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55777670
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50673235
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50267262
52MYC_22102868_ChIP-Seq_BL_Human1.49957689
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.48795250
54VDR_21846776_ChIP-Seq_THP-1_Human1.47400942
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46682422
56CIITA_25753668_ChIP-Seq_RAJI_Human1.46233090
57KDM5A_27292631_Chip-Seq_BREAST_Human1.44162506
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43263924
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43103945
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39795703
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38940194
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.38026737
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31927962
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30627470
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28471123
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27001916
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23987822
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17532763
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16513649
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16463111
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15351989
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13906355
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13906355
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13906355
75MYC_18940864_ChIP-ChIP_HL60_Human1.13424639
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.12913163
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10086417
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08707448
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07443309
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03781636
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02938519
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02715505
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02449368
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02188840
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01523938
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.01325896
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01108923
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99404317
89IRF1_19129219_ChIP-ChIP_H3396_Human0.96624271
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94610303
91GATA1_22025678_ChIP-Seq_K562_Human0.94316982
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.93394243
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92048189
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.91445778
95TFEB_21752829_ChIP-Seq_HELA_Human0.91169231
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90086982
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88019742
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84563313
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84289551
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83342914
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81595729
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.81552842
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81201872
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80910322
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80765440
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80366435
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80279549
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79897601
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78442338
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77879764
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77727913
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76667424
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76576586
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76293048
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75487578
116CHD1_26751641_Chip-Seq_LNCaP_Human0.75457672
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72599618
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72243210
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70769685
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.70723202
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69370223
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68532921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.12758520
2MP0003693_abnormal_embryo_hatching4.99069646
3MP0008057_abnormal_DNA_replication4.70534204
4MP0003111_abnormal_nucleus_morphology4.49924550
5MP0004957_abnormal_blastocyst_morpholog4.31560657
6MP0008058_abnormal_DNA_repair4.10920190
7MP0003077_abnormal_cell_cycle3.95061876
8MP0008877_abnormal_DNA_methylation3.22793729
9MP0002163_abnormal_gland_morphology2.79001476
10MP0008007_abnormal_cellular_replicative2.67506241
11MP0008932_abnormal_embryonic_tissue2.61784771
12MP0002396_abnormal_hematopoietic_system2.55852158
13MP0003123_paternal_imprinting2.44115320
14MP0005410_abnormal_fertilization2.41660944
15MP0001730_embryonic_growth_arrest2.40457924
16MP0001661_extended_life_span2.16100485
17MP0000350_abnormal_cell_proliferation2.16009879
18MP0010352_gastrointestinal_tract_polyps2.11906733
19MP0010307_abnormal_tumor_latency2.11613229
20MP0001929_abnormal_gametogenesis1.99095493
21MP0003786_premature_aging1.98405748
22MP0002210_abnormal_sex_determination1.91832856
23MP0002653_abnormal_ependyma_morphology1.89382842
24MP0005409_darkened_coat_color1.82804309
25MP0002089_abnormal_postnatal_growth/wei1.81771797
26MP0001672_abnormal_embryogenesis/_devel1.80961466
27MP0005380_embryogenesis_phenotype1.80961466
28MP0001697_abnormal_embryo_size1.79368766
29MP0001145_abnormal_male_reproductive1.71280608
30MP0003984_embryonic_growth_retardation1.66772871
31MP0000751_myopathy1.66369717
32MP0000490_abnormal_crypts_of1.64829263
33MP0004808_abnormal_hematopoietic_stem1.63059352
34MP0002080_prenatal_lethality1.62917419
35MP0003698_abnormal_male_reproductive1.62852716
36MP0002085_abnormal_embryonic_tissue1.62461956
37MP0002088_abnormal_embryonic_growth/wei1.62084912
38MP0002084_abnormal_developmental_patter1.60445008
39MP0003890_abnormal_embryonic-extraembry1.57358646
40MP0000313_abnormal_cell_death1.50158114
41MP0000653_abnormal_sex_gland1.48452597
42MP0004197_abnormal_fetal_growth/weight/1.45297289
43MP0001293_anophthalmia1.42778585
44MP0003121_genomic_imprinting1.41954810
45MP0002086_abnormal_extraembryonic_tissu1.40384915
46MP0000750_abnormal_muscle_regeneration1.40041132
47MP0002019_abnormal_tumor_incidence1.39073200
48MP0003763_abnormal_thymus_physiology1.33514846
49MP0009379_abnormal_foot_pigmentation1.32200494
50MP0005379_endocrine/exocrine_gland_phen1.30999566
51MP0000678_abnormal_parathyroid_gland1.27164814
52MP0003718_maternal_effect1.26034469
53MP0000703_abnormal_thymus_morphology1.23272449
54MP0005076_abnormal_cell_differentiation1.18822488
55MP0004215_abnormal_myocardial_fiber1.12496636
56MP0005220_abnormal_exocrine_pancreas1.10950752
57MP0002009_preneoplasia1.09646051
58MP0003567_abnormal_fetal_cardiomyocyte1.07990258
59MP0002102_abnormal_ear_morphology1.05915454
60MP0002269_muscular_atrophy1.04233002
61MP0002161_abnormal_fertility/fecundity1.03689864
62MP0004185_abnormal_adipocyte_glucose1.02898929
63MP0010368_abnormal_lymphatic_system1.02122588
64MP0001545_abnormal_hematopoietic_system1.01080747
65MP0005397_hematopoietic_system_phenotyp1.01080747
66MP0002398_abnormal_bone_marrow0.99498139
67MP0006138_congestive_heart_failure0.99214687
68MP0004233_abnormal_muscle_weight0.99155045
69MP0004133_heterotaxia0.99070924
70MP0002160_abnormal_reproductive_system0.96896820
71MP0003183_abnormal_peptide_metabolism0.96809846
72MP0009333_abnormal_splenocyte_physiolog0.94660985
73MP0002877_abnormal_melanocyte_morpholog0.94091606
74MP0010030_abnormal_orbit_morphology0.93573026
75MP0002722_abnormal_immune_system0.93468382
76MP0006292_abnormal_olfactory_placode0.92970759
77MP0000579_abnormal_nail_morphology0.91121107
78MP0000049_abnormal_middle_ear0.90375733
79MP0004087_abnormal_muscle_fiber0.88707996
80MP0005330_cardiomyopathy0.87053682
81MP0003646_muscle_fatigue0.86752219
82MP0001348_abnormal_lacrimal_gland0.86112268
83MP0001119_abnormal_female_reproductive0.85252799
84MP0000358_abnormal_cell_content/0.84711821
85MP0000689_abnormal_spleen_morphology0.83711563
86MP0003119_abnormal_digestive_system0.83649240
87MP0009672_abnormal_birth_weight0.83036816
88MP0010630_abnormal_cardiac_muscle0.81278155
89MP0003315_abnormal_perineum_morphology0.79720492
90MP0008995_early_reproductive_senescence0.77817923
91MP0005623_abnormal_meninges_morphology0.77809152
92MP0003937_abnormal_limbs/digits/tail_de0.77554083
93MP0004084_abnormal_cardiac_muscle0.77191778
94MP0002132_abnormal_respiratory_system0.76780848
95MP0002106_abnormal_muscle_physiology0.76626226
96MP0005389_reproductive_system_phenotype0.76173365
97MP0009703_decreased_birth_body0.75163650
98MP0002796_impaired_skin_barrier0.74410462
99MP0000467_abnormal_esophagus_morphology0.73970396
100MP0000747_muscle_weakness0.73872997
101MP0002111_abnormal_tail_morphology0.73560885
102MP0004272_abnormal_basement_membrane0.71710510
103MP0005501_abnormal_skin_physiology0.71250517
104MP0002429_abnormal_blood_cell0.71224876
105MP0005384_cellular_phenotype0.70558315
106MP0001270_distended_abdomen0.69027272
107MP0000372_irregular_coat_pigmentation0.67985543
108MP0000762_abnormal_tongue_morphology0.66977851
109MP0000432_abnormal_head_morphology0.66448465
110MP0008789_abnormal_olfactory_epithelium0.66378024
111MP0000733_abnormal_muscle_development0.65936427
112MP0001346_abnormal_lacrimal_gland0.65908264
113MP0001879_abnormal_lymphatic_vessel0.65797418
114MP0002095_abnormal_skin_pigmentation0.65490453
115MP0005369_muscle_phenotype0.65466021
116MP0006036_abnormal_mitochondrial_physio0.65463274
117MP0006054_spinal_hemorrhage0.65025228
118MP0000371_diluted_coat_color0.64629403
119MP0000613_abnormal_salivary_gland0.64521787
120MP0000858_altered_metastatic_potential0.63760607
121MP0002060_abnormal_skin_morphology0.63687273
122MP0001915_intracranial_hemorrhage0.62276294
123MP0005621_abnormal_cell_physiology0.61123677
124MP0000537_abnormal_urethra_morphology0.60013889
125MP0002092_abnormal_eye_morphology0.60006338
126MP0002932_abnormal_joint_morphology0.59835938
127MP0003861_abnormal_nervous_system0.59615172
128MP0005174_abnormal_tail_pigmentation0.59060783
129MP0001286_abnormal_eye_development0.58529280
130MP0000716_abnormal_immune_system0.57330462
131MP0009053_abnormal_anal_canal0.55797766
132MP0003806_abnormal_nucleotide_metabolis0.55471993
133MP0002114_abnormal_axial_skeleton0.55258855
134MP0002282_abnormal_trachea_morphology0.55190202
135MP0003941_abnormal_skin_development0.55183490
136MP0003699_abnormal_female_reproductive0.54714906
137MP0000477_abnormal_intestine_morphology0.54347641
138MP0000428_abnormal_craniofacial_morphol0.53895400
139MP0003221_abnormal_cardiomyocyte_apopto0.53133151
140MP0006035_abnormal_mitochondrial_morpho0.52605748
141MP0003935_abnormal_craniofacial_develop0.50965977
142MP0009697_abnormal_copulation0.50628383
143MP0008770_decreased_survivor_rate0.49447183
144MP0001919_abnormal_reproductive_system0.48619405
145MP0005394_taste/olfaction_phenotype0.47170327

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.27689071
2Anomalous pulmonary venous return (HP:0010772)4.74573039
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.45372526
4Progressive muscle weakness (HP:0003323)4.41569070
5Abnormality of the pulmonary veins (HP:0011718)4.05130707
6Chromsome breakage (HP:0040012)3.88298490
7Reticulocytopenia (HP:0001896)3.75717684
8Diastasis recti (HP:0001540)3.72054921
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64602550
10Urethral obstruction (HP:0000796)3.51682594
11Breast hypoplasia (HP:0003187)3.38906040
12Abnormality of cells of the erythroid lineage (HP:0012130)3.29449982
13Selective tooth agenesis (HP:0001592)3.27016117
14Abnormal number of erythroid precursors (HP:0012131)3.20259126
15Vertebral arch anomaly (HP:0008438)3.12354981
16Patellar aplasia (HP:0006443)3.07872076
17Colon cancer (HP:0003003)3.05193040
18Medulloblastoma (HP:0002885)3.02285738
19Abnormality of chromosome stability (HP:0003220)2.99648880
20Meckel diverticulum (HP:0002245)2.95610692
21Abnormality of the preputium (HP:0100587)2.94782231
22Oral leukoplakia (HP:0002745)2.91179651
23Impulsivity (HP:0100710)2.89660757
24Aplasia/Hypoplasia of the patella (HP:0006498)2.87862625
25Abnormality of the ileum (HP:0001549)2.85165391
26Supernumerary spleens (HP:0009799)2.84215886
27Abnormality of the labia minora (HP:0012880)2.78935338
28Ependymoma (HP:0002888)2.75322524
29Abnormal trabecular bone morphology (HP:0100671)2.74862720
30Increased nuchal translucency (HP:0010880)2.74323208
31Absent/shortened dynein arms (HP:0200106)2.71787738
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.71787738
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.70885171
34Myelodysplasia (HP:0002863)2.65752430
35Agnosia (HP:0010524)2.62459277
36Aplastic anemia (HP:0001915)2.62121791
3711 pairs of ribs (HP:0000878)2.60704510
38Sloping forehead (HP:0000340)2.60186490
39Myelomeningocele (HP:0002475)2.59087061
40Absent radius (HP:0003974)2.56544745
41Abnormal respiratory motile cilium morphology (HP:0005938)2.55924843
42Abnormal respiratory epithelium morphology (HP:0012253)2.55924843
43Preauricular pit (HP:0004467)2.54736972
44Periauricular skin pits (HP:0100277)2.54736972
45Abnormality of cochlea (HP:0000375)2.54577945
46Duodenal stenosis (HP:0100867)2.53178532
47Small intestinal stenosis (HP:0012848)2.53178532
48Degeneration of anterior horn cells (HP:0002398)2.50846422
49Abnormality of the anterior horn cell (HP:0006802)2.50846422
50Absent thumb (HP:0009777)2.50271030
51Rhinitis (HP:0012384)2.50246505
52Duplicated collecting system (HP:0000081)2.50188388
53Pallor (HP:0000980)2.48765817
54Abnormal spermatogenesis (HP:0008669)2.48634082
55Abnormal respiratory motile cilium physiology (HP:0012261)2.45862719
56Abnormal lung lobation (HP:0002101)2.44540657
57Rough bone trabeculation (HP:0100670)2.41294496
58Facial cleft (HP:0002006)2.41018686
59Carpal bone hypoplasia (HP:0001498)2.40581065
60Macrocytic anemia (HP:0001972)2.40148970
61Absent forearm bone (HP:0003953)2.38654703
62Aplasia involving forearm bones (HP:0009822)2.38654703
63Premature graying of hair (HP:0002216)2.36580895
64Progressive external ophthalmoplegia (HP:0000590)2.36477976
65Ectopic kidney (HP:0000086)2.36413484
66Skin pits (HP:0100276)2.35292933
67Neoplasm of the pancreas (HP:0002894)2.33358195
68Ureteral duplication (HP:0000073)2.33117855
69Rhabdomyosarcoma (HP:0002859)2.30324158
70Nephroblastoma (Wilms tumor) (HP:0002667)2.26005316
71Nasal polyposis (HP:0100582)2.22961294
72Abnormality of the renal collecting system (HP:0004742)2.22645320
73Bone marrow hypocellularity (HP:0005528)2.21620720
74J-shaped sella turcica (HP:0002680)2.20207165
75Abnormality of the carotid arteries (HP:0005344)2.17927367
76Cerebral hypomyelination (HP:0006808)2.16507779
77Abnormal number of incisors (HP:0011064)2.16431883
78Proximal placement of thumb (HP:0009623)2.15963864
79Basal cell carcinoma (HP:0002671)2.15399311
80Abnormal ciliary motility (HP:0012262)2.13122900
81Atresia of the external auditory canal (HP:0000413)2.11623572
82Embryonal renal neoplasm (HP:0011794)2.11295192
83Oligodontia (HP:0000677)2.10081106
84Ridged nail (HP:0001807)2.08870920
85Deviation of the thumb (HP:0009603)2.08777927
86Chronic bronchitis (HP:0004469)2.07536789
87Horseshoe kidney (HP:0000085)2.06854841
88Abnormality of the duodenum (HP:0002246)2.06777955
89Tracheoesophageal fistula (HP:0002575)2.05581797
90Triphalangeal thumb (HP:0001199)2.05333080
91Absent eyelashes (HP:0000561)2.05299501
92Sparse lateral eyebrow (HP:0005338)2.04017387
93Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03860987
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.01987792
95Volvulus (HP:0002580)2.01173336
96Hemivertebrae (HP:0002937)2.01036401
97Facial hemangioma (HP:0000329)1.97032488
98Lip pit (HP:0100267)1.96941937
99Squamous cell carcinoma (HP:0002860)1.95798871
100Microvesicular hepatic steatosis (HP:0001414)1.95629007
101Nonimmune hydrops fetalis (HP:0001790)1.94716817
102Pancreatic fibrosis (HP:0100732)1.93209603
103Overlapping toe (HP:0001845)1.92898374
104Cellular immunodeficiency (HP:0005374)1.92555807
105Vertebral fusion (HP:0002948)1.92076134
106Abnormality of the odontoid process (HP:0003310)1.91486853
107Clubbing of toes (HP:0100760)1.91112099
108Aortic regurgitation (HP:0001659)1.90971279
109Prominent occiput (HP:0000269)1.90808972
110Septate vagina (HP:0001153)1.89587857
111Broad alveolar ridges (HP:0000187)1.88861159
112Missing ribs (HP:0000921)1.88491990
113Intestinal fistula (HP:0100819)1.87134662
114Amaurosis fugax (HP:0100576)1.85842452
115Abdominal situs inversus (HP:0003363)1.85812811
116Abnormality of abdominal situs (HP:0011620)1.85812811
117Abnormality of the lumbar spine (HP:0100712)1.85646135
118Prominent nose (HP:0000448)1.84014009
119Short thumb (HP:0009778)1.83617122
120Small epiphyses (HP:0010585)1.83551641
121Bronchitis (HP:0012387)1.83080687
122Microretrognathia (HP:0000308)1.82914836
123Flat acetabular roof (HP:0003180)1.81872326
124Muscle fiber atrophy (HP:0100295)1.81190471
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80591985
126Cleft eyelid (HP:0000625)1.79993116
127Abnormality of the intervertebral disk (HP:0005108)1.79476511
128Premature ovarian failure (HP:0008209)1.79324480
129Decreased circulating renin level (HP:0003351)1.78088897
130Abnormality of DNA repair (HP:0003254)1.77991246
131Cafe-au-lait spot (HP:0000957)1.77964676
132Medial flaring of the eyebrow (HP:0010747)1.77652873
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77437596
134Deformed sella turcica (HP:0002681)1.76677786
135Rectal fistula (HP:0100590)1.76099174
136Rectovaginal fistula (HP:0000143)1.76099174
137Type 2 muscle fiber atrophy (HP:0003554)1.74791154
138Reduced antithrombin III activity (HP:0001976)1.74476423
139Abnormality of the pons (HP:0007361)1.74344531
140Lymphoma (HP:0002665)1.73924255
141Hypoplasia of the pons (HP:0012110)1.73875022
142Multiple enchondromatosis (HP:0005701)1.73796337
143Glioma (HP:0009733)1.73125562
144Astrocytoma (HP:0009592)1.71280384
145Abnormality of the astrocytes (HP:0100707)1.71280384
146Ragged-red muscle fibers (HP:0003200)1.70125014
147Dysmetric saccades (HP:0000641)1.68067176
148Persistence of primary teeth (HP:0006335)1.66597579
149Pancytopenia (HP:0001876)1.63698061
150Abnormality of the fetal cardiovascular system (HP:0010948)1.61957751
151Single umbilical artery (HP:0001195)1.61957751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK7.15188190
2WEE14.64282363
3CDC74.38296482
4BUB13.78551726
5TSSK62.95339525
6EIF2AK12.76706427
7BRSK22.63095663
8PDK32.59557081
9PDK42.59557081
10SRPK12.58104751
11CDK122.53202376
12NEK22.52185034
13PLK42.43530506
14TLK12.30866370
15TTK2.14143500
16MKNK12.10910119
17NEK12.04596863
18VRK11.99277169
19PLK11.95923534
20ACVR1B1.93923048
21MKNK21.90432159
22ATR1.87412134
23STK161.79968205
24CHEK21.75597803
25EIF2AK31.74992948
26CDK71.73902774
27PLK31.67355132
28EPHA21.65214798
29PASK1.64754397
30AURKB1.59876658
31ZAK1.53125710
32PDK21.52316025
33TAF11.52236037
34BRSK11.50252932
35RPS6KB21.48762629
36BRD41.44964750
37TESK21.44550004
38CHEK11.43224429
39CCNB11.40131035
40NME21.33058660
41SMG11.32892835
42DYRK31.27637503
43CDK41.27081980
44PNCK1.23286952
45SCYL21.20419816
46AURKA1.19906362
47PRPF4B1.17255285
48EEF2K1.13724778
49RPS6KA41.06105906
50VRK21.03307483
51ATM1.02809757
52STK101.02053513
53MAP3K80.99370801
54CDK20.93171910
55PIM10.90490702
56TGFBR10.84522762
57LATS20.82236605
58CAMK40.77862551
59STK40.77742113
60MAP4K10.76041259
61* CSNK2A20.75989547
62WNK40.71872309
63ALK0.71422180
64CDK10.69660666
65PAK40.66513648
66TNIK0.66489227
67ICK0.65621986
68PIM20.64964636
69CSNK2A10.64630515
70TRIB30.63999862
71MST1R0.62335500
72STK38L0.61592929
73CDK80.60863197
74IRAK30.60591192
75MELK0.59264466
76EIF2AK20.57981004
77STK30.57938956
78PAK10.57086954
79DAPK30.56962446
80NEK90.56280735
81ZAP700.53920508
82AKT30.53366870
83PRKCI0.53075179
84YES10.52679393
85CDK60.52207116
86RPS6KA50.51115329
87MAP3K100.50452512
88CAMK1D0.48910666
89WNK10.48771734
90RPS6KA60.48262249
91CLK10.47520726
92CSNK1E0.46945907
93CDK90.46300328
94MAP3K90.45916576
95MAPK110.43350875
96RPS6KL10.42925220
97RPS6KC10.42925220
98PRKDC0.42881851
99AKT10.39977837
100NME10.37862676
101AKT20.36160198
102MTOR0.35836244
103RIPK10.34994201
104FLT30.34909137
105ERBB40.34661266
106TEC0.34069151
107MAP3K30.32910983
108MATK0.32881590
109KDR0.32874609
110INSRR0.32788479
111MARK30.32489109
112BRAF0.31004839
113MAPK140.30347168
114MAP3K60.29620262
115PRKAA10.28577815
116SYK0.27856896
117CSNK1D0.27654878
118CDK30.27196192
119STK240.27099267
120TESK10.27035468
121PBK0.26621406
122PAK20.25753624
123PKN20.24767089
124BTK0.24344439
125TXK0.24076841
126RPS6KB10.23566757
127GSK3B0.21281558
128FGFR10.20369347
129GRK60.18591596
130LRRK20.13888880
131MAP2K30.13194590
132MAP3K110.12747661
133MAPK10.12662542
134LATS10.12263986

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82597564
2Mismatch repair_Homo sapiens_hsa034304.17480880
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07512924
4RNA transport_Homo sapiens_hsa030133.48553419
5Spliceosome_Homo sapiens_hsa030403.48542749
6Ribosome_Homo sapiens_hsa030103.32848378
7Homologous recombination_Homo sapiens_hsa034403.25345062
8RNA polymerase_Homo sapiens_hsa030203.01712912
9Proteasome_Homo sapiens_hsa030502.90783091
10Base excision repair_Homo sapiens_hsa034102.90338406
11Cell cycle_Homo sapiens_hsa041102.81513726
12Nucleotide excision repair_Homo sapiens_hsa034202.77099976
13Fanconi anemia pathway_Homo sapiens_hsa034602.63342727
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59324927
15One carbon pool by folate_Homo sapiens_hsa006702.49952817
16Basal transcription factors_Homo sapiens_hsa030222.39323067
17Pyrimidine metabolism_Homo sapiens_hsa002402.33836486
18Non-homologous end-joining_Homo sapiens_hsa034502.20430035
19RNA degradation_Homo sapiens_hsa030182.03437649
20mRNA surveillance pathway_Homo sapiens_hsa030151.99437578
21Systemic lupus erythematosus_Homo sapiens_hsa053221.93960375
22p53 signaling pathway_Homo sapiens_hsa041151.63253082
23Purine metabolism_Homo sapiens_hsa002301.43078337
24Pentose phosphate pathway_Homo sapiens_hsa000301.42556216
25Epstein-Barr virus infection_Homo sapiens_hsa051691.24642907
26Oocyte meiosis_Homo sapiens_hsa041141.20156475
27Viral carcinogenesis_Homo sapiens_hsa052031.15866364
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07975650
29Antigen processing and presentation_Homo sapiens_hsa046121.01260490
30Biosynthesis of amino acids_Homo sapiens_hsa012300.98120619
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93943409
32Herpes simplex infection_Homo sapiens_hsa051680.93396645
33Vitamin B6 metabolism_Homo sapiens_hsa007500.91004121
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89655679
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89212292
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.85418481
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83640643
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75978692
39HTLV-I infection_Homo sapiens_hsa051660.75913301
40Alcoholism_Homo sapiens_hsa050340.75730772
41Renin-angiotensin system_Homo sapiens_hsa046140.71918502
42Dilated cardiomyopathy_Homo sapiens_hsa054140.70117559
43Selenocompound metabolism_Homo sapiens_hsa004500.69945477
44Huntingtons disease_Homo sapiens_hsa050160.69616350
45N-Glycan biosynthesis_Homo sapiens_hsa005100.69197787
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63141097
47Vitamin digestion and absorption_Homo sapiens_hsa049770.60664530
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58275609
49Primary immunodeficiency_Homo sapiens_hsa053400.58251751
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58116924
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57701324
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.57433138
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56330078
54MicroRNAs in cancer_Homo sapiens_hsa052060.56179054
55Parkinsons disease_Homo sapiens_hsa050120.55423366
56Protein export_Homo sapiens_hsa030600.53204501
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52745512
58Carbon metabolism_Homo sapiens_hsa012000.52686670
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51511400
60Small cell lung cancer_Homo sapiens_hsa052220.51087806
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47841908
62Thyroid cancer_Homo sapiens_hsa052160.46854017
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46841629
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44869251
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44258269
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43281694
67Legionellosis_Homo sapiens_hsa051340.43057680
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.42014610
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39908246
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39743263
71Cardiac muscle contraction_Homo sapiens_hsa042600.37976349
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37450259
73Lysine degradation_Homo sapiens_hsa003100.36080424
74Non-small cell lung cancer_Homo sapiens_hsa052230.34761960
75Measles_Homo sapiens_hsa051620.33721519
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32897074
77Melanoma_Homo sapiens_hsa052180.32366359
78Fatty acid biosynthesis_Homo sapiens_hsa000610.31956568
79Glutathione metabolism_Homo sapiens_hsa004800.30656052
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30060669
81TGF-beta signaling pathway_Homo sapiens_hsa043500.29633391
82Colorectal cancer_Homo sapiens_hsa052100.29252353
83Folate biosynthesis_Homo sapiens_hsa007900.27904553
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27640402
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27605342
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26925248
87Sulfur relay system_Homo sapiens_hsa041220.26849201
88Hippo signaling pathway_Homo sapiens_hsa043900.26808551
89Hepatitis B_Homo sapiens_hsa051610.26395934
90Apoptosis_Homo sapiens_hsa042100.25513768
91Shigellosis_Homo sapiens_hsa051310.24456541
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24419390
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24398945
94Fructose and mannose metabolism_Homo sapiens_hsa000510.24112833
95Basal cell carcinoma_Homo sapiens_hsa052170.23865197
96HIF-1 signaling pathway_Homo sapiens_hsa040660.23429731
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.23241855
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.22480248
99Ovarian steroidogenesis_Homo sapiens_hsa049130.20085504
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18480136
101Hematopoietic cell lineage_Homo sapiens_hsa046400.16977985
102Pathways in cancer_Homo sapiens_hsa052000.16911033
103Metabolic pathways_Homo sapiens_hsa011000.16387055
104Alzheimers disease_Homo sapiens_hsa050100.16234448
105Chronic myeloid leukemia_Homo sapiens_hsa052200.15498651
106Influenza A_Homo sapiens_hsa051640.14799698
107Olfactory transduction_Homo sapiens_hsa047400.14688270
108Bladder cancer_Homo sapiens_hsa052190.13339682
109Viral myocarditis_Homo sapiens_hsa054160.12928925
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12653664
111Notch signaling pathway_Homo sapiens_hsa043300.12378428
112Taste transduction_Homo sapiens_hsa047420.11975446
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11319280
114Glucagon signaling pathway_Homo sapiens_hsa049220.10840490
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10766947
116T cell receptor signaling pathway_Homo sapiens_hsa046600.09215174
117Type I diabetes mellitus_Homo sapiens_hsa049400.09141927
118Wnt signaling pathway_Homo sapiens_hsa043100.09033385
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.08416370
120Hedgehog signaling pathway_Homo sapiens_hsa043400.08210623
121FoxO signaling pathway_Homo sapiens_hsa040680.08014659
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06843370
123Adherens junction_Homo sapiens_hsa045200.06824158
124Prostate cancer_Homo sapiens_hsa052150.06659324
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.06031436
126Galactose metabolism_Homo sapiens_hsa000520.05907926
127mTOR signaling pathway_Homo sapiens_hsa041500.05828009
128Pyruvate metabolism_Homo sapiens_hsa006200.05752136
129Allograft rejection_Homo sapiens_hsa053300.04873010

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