NOP56P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.69930477
2pyrimidine nucleobase catabolic process (GO:0006208)5.40837544
3gamma-aminobutyric acid transport (GO:0015812)4.94308215
4negative regulation of response to food (GO:0032096)4.48831151
5negative regulation of appetite (GO:0032099)4.48831151
6DNA double-strand break processing (GO:0000729)4.38881015
7nucleobase catabolic process (GO:0046113)4.25257919
8glycine transport (GO:0015816)4.20940083
9axonal fasciculation (GO:0007413)4.18485982
10prepulse inhibition (GO:0060134)4.10077200
11regulation of cilium movement (GO:0003352)4.07900480
12head development (GO:0060322)4.04252742
13auditory behavior (GO:0031223)4.04085086
14protein neddylation (GO:0045116)3.93999452
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.92581858
16nonmotile primary cilium assembly (GO:0035058)3.76761727
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74635119
18mechanosensory behavior (GO:0007638)3.70944245
19regulation of microtubule-based movement (GO:0060632)3.63508255
20neurofilament cytoskeleton organization (GO:0060052)3.63050554
21cell proliferation in forebrain (GO:0021846)3.63007371
22serotonin metabolic process (GO:0042428)3.61979729
23retinal rod cell development (GO:0046548)3.61682356
24cell migration in hindbrain (GO:0021535)3.60079802
25anterograde synaptic vesicle transport (GO:0048490)3.59085024
26synaptic transmission, glutamatergic (GO:0035249)3.50558574
27regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.49159743
28short-term memory (GO:0007614)3.45819778
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45083762
30dendrite development (GO:0016358)3.43708316
31neuronal action potential propagation (GO:0019227)3.43502165
32glutamate receptor signaling pathway (GO:0007215)3.38299927
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33412287
34response to auditory stimulus (GO:0010996)3.32720909
35neuron recognition (GO:0008038)3.29321057
36primary amino compound metabolic process (GO:1901160)3.28029399
37presynaptic membrane organization (GO:0097090)3.24666475
38brain morphogenesis (GO:0048854)3.16582584
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15942659
40detection of light stimulus involved in visual perception (GO:0050908)3.13862519
41detection of light stimulus involved in sensory perception (GO:0050962)3.13862519
42intraciliary transport (GO:0042073)3.13270861
43synaptic vesicle maturation (GO:0016188)3.06921522
44retinal ganglion cell axon guidance (GO:0031290)3.05591836
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04935464
46photoreceptor cell development (GO:0042461)3.01024018
47regulation of helicase activity (GO:0051095)3.00691161
48striatum development (GO:0021756)3.00630877
49regulation of non-canonical Wnt signaling pathway (GO:2000050)2.95664949
50cellular response to leptin stimulus (GO:0044320)2.87249667
51protein-cofactor linkage (GO:0018065)2.87143852
52anterograde axon cargo transport (GO:0008089)2.86389368
53positive regulation of dendritic spine morphogenesis (GO:0061003)2.85683620
54hippocampus development (GO:0021766)2.84916970
55neuromuscular synaptic transmission (GO:0007274)2.83229024
56cranial nerve development (GO:0021545)2.80534425
57regulation of mesoderm development (GO:2000380)2.79157607
58regulation of response to food (GO:0032095)2.77954514
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77495463
60postsynaptic membrane organization (GO:0001941)2.72842477
61neuron-neuron synaptic transmission (GO:0007270)2.72627896
62vocalization behavior (GO:0071625)2.72482690
63chromatin remodeling at centromere (GO:0031055)2.71738641
64regulation of synapse structural plasticity (GO:0051823)2.71283641
65positive regulation of potassium ion transmembrane transport (GO:1901381)2.70257295
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68659551
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67178466
68axon cargo transport (GO:0008088)2.65920838
69presynaptic membrane assembly (GO:0097105)2.65417579
70substrate-independent telencephalic tangential migration (GO:0021826)2.61911255
71substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61911255
72neuron cell-cell adhesion (GO:0007158)2.60809853
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57486603
74neurotransmitter biosynthetic process (GO:0042136)2.56670189
75dendrite morphogenesis (GO:0048813)2.56659086
76axon extension (GO:0048675)2.55943884
77synaptic transmission, cholinergic (GO:0007271)2.55829982
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55721874
79establishment of protein localization to mitochondrial membrane (GO:0090151)2.55602076
80C4-dicarboxylate transport (GO:0015740)2.52923755
81melanosome transport (GO:0032402)2.52841950
82chaperone-mediated protein transport (GO:0072321)2.51877194
83interkinetic nuclear migration (GO:0022027)2.51583094
84regulation of appetite (GO:0032098)2.51319591
85water-soluble vitamin biosynthetic process (GO:0042364)2.51211701
86protein localization to synapse (GO:0035418)2.51069073
87neuronal ion channel clustering (GO:0045161)2.50723199
88somite development (GO:0061053)2.50084478
89atrial cardiac muscle cell action potential (GO:0086014)2.48549378
90regulation of telomere maintenance (GO:0032204)2.48394680
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.47687288
92establishment of melanosome localization (GO:0032401)2.46520285
93heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.44375459
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.43936324
95ATP synthesis coupled proton transport (GO:0015986)2.43936324
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.43870793
97hypothalamus development (GO:0021854)2.43285571
98appendage development (GO:0048736)2.42728496
99limb development (GO:0060173)2.42728496
100positive regulation of sodium ion transmembrane transport (GO:1902307)2.41612418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.32556814
2GBX2_23144817_ChIP-Seq_PC3_Human2.91397715
3IGF1R_20145208_ChIP-Seq_DFB_Human2.90869460
4VDR_22108803_ChIP-Seq_LS180_Human2.75530429
5ZNF274_21170338_ChIP-Seq_K562_Hela2.58636191
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37817277
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31033631
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23896224
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07105401
10REST_21632747_ChIP-Seq_MESCs_Mouse2.02907659
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02844747
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00659005
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00220144
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95408542
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94225618
16TAF15_26573619_Chip-Seq_HEK293_Human1.93442806
17FUS_26573619_Chip-Seq_HEK293_Human1.82507768
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.82254181
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82119938
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79109194
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78923781
22EWS_26573619_Chip-Seq_HEK293_Human1.76056354
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.75398001
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.74619146
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72730853
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69999778
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.68799126
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.68600329
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.65894868
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64376372
31P300_19829295_ChIP-Seq_ESCs_Human1.63324045
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.59498371
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58423356
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.55215441
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54986511
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.51203328
37SMAD4_21799915_ChIP-Seq_A2780_Human1.50369785
38FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.45524405
39IRF1_19129219_ChIP-ChIP_H3396_Human1.44060245
40CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.42143074
41P53_22127205_ChIP-Seq_FIBROBLAST_Human1.42035579
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40578607
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39867229
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39722796
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39077585
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37028680
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36614922
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36066776
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33276528
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32535730
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31352113
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.31042226
53RNF2_27304074_Chip-Seq_NSC_Mouse1.29948266
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27697170
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27111799
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26509585
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25922774
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.23859764
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.23361326
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23287041
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23211455
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.22427693
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22332962
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.20192549
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19985063
66STAT3_23295773_ChIP-Seq_U87_Human1.18674155
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18122693
68CBP_20019798_ChIP-Seq_JUKART_Human1.16582835
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16582835
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16490175
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15118120
72BCAT_22108803_ChIP-Seq_LS180_Human1.14876480
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13929391
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12794368
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11785488
76ER_23166858_ChIP-Seq_MCF-7_Human1.10674520
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10659849
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10633653
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10492384
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10090578
81MYC_18940864_ChIP-ChIP_HL60_Human1.10085679
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.09686726
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09388674
84ELK1_19687146_ChIP-ChIP_HELA_Human1.09105780
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08126273
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.07403263
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07355279
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07355279
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.05750176
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.04757340
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03721414
92EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03188389
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03188389
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02507438
95POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.02488015
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02342463
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01869270
98P53_22387025_ChIP-Seq_ESCs_Mouse1.01835982
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99511139
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99248870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.88440533
2MP0003878_abnormal_ear_physiology3.49201076
3MP0005377_hearing/vestibular/ear_phenot3.49201076
4MP0001348_abnormal_lacrimal_gland3.30491759
5MP0001188_hyperpigmentation3.26778148
6MP0003136_yellow_coat_color2.84779139
7MP0008789_abnormal_olfactory_epithelium2.56751154
8MP0005423_abnormal_somatic_nervous2.52165001
9MP0002822_catalepsy2.31686664
10MP0002272_abnormal_nervous_system2.24932764
11MP0002254_reproductive_system_inflammat2.17362773
12MP0000778_abnormal_nervous_system2.17267617
13MP0004142_abnormal_muscle_tone2.16350460
14MP0005394_taste/olfaction_phenotype2.13114396
15MP0005499_abnormal_olfactory_system2.13114396
16MP0006292_abnormal_olfactory_placode2.05165726
17MP0002638_abnormal_pupillary_reflex2.03188523
18MP0003635_abnormal_synaptic_transmissio2.02671283
19MP0001293_anophthalmia1.90857044
20MP0004859_abnormal_synaptic_plasticity1.79221571
21MP0000049_abnormal_middle_ear1.78442217
22MP0002837_dystrophic_cardiac_calcinosis1.75198432
23MP0005551_abnormal_eye_electrophysiolog1.72175178
24MP0001968_abnormal_touch/_nociception1.70778163
25MP0003787_abnormal_imprinting1.67606806
26MP0002736_abnormal_nociception_after1.62281927
27MP0002184_abnormal_innervation1.60950459
28MP0003123_paternal_imprinting1.60854347
29MP0009745_abnormal_behavioral_response1.59179577
30MP0005084_abnormal_gallbladder_morpholo1.58507031
31MP0009046_muscle_twitch1.57953075
32MP0003937_abnormal_limbs/digits/tail_de1.54520426
33MP0003880_abnormal_central_pattern1.51018245
34MP0003567_abnormal_fetal_cardiomyocyte1.48770302
35MP0003121_genomic_imprinting1.44968423
36MP0001286_abnormal_eye_development1.39624078
37MP0002697_abnormal_eye_size1.37340064
38MP0001502_abnormal_circadian_rhythm1.37187959
39MP0002734_abnormal_mechanical_nocicepti1.37149210
40MP0002233_abnormal_nose_morphology1.35564928
41MP0004885_abnormal_endolymph1.35529376
42MP0000372_irregular_coat_pigmentation1.34728930
43MP0003938_abnormal_ear_development1.34588231
44MP0002064_seizures1.32198744
45MP0002160_abnormal_reproductive_system1.31704799
46MP0002557_abnormal_social/conspecific_i1.31097207
47MP0002572_abnormal_emotion/affect_behav1.27519978
48MP0001485_abnormal_pinna_reflex1.25263751
49MP0001984_abnormal_olfaction1.24059571
50MP0005253_abnormal_eye_physiology1.23881979
51MP0010386_abnormal_urinary_bladder1.22656551
52MP0006072_abnormal_retinal_apoptosis1.22259544
53MP0004133_heterotaxia1.22045749
54MP0004270_analgesia1.21367742
55MP0002063_abnormal_learning/memory/cond1.20488682
56MP0003942_abnormal_urinary_system1.20237241
57MP0000631_abnormal_neuroendocrine_gland1.19924164
58MP0003646_muscle_fatigue1.19717900
59MP0006276_abnormal_autonomic_nervous1.19596095
60MP0002751_abnormal_autonomic_nervous1.19337864
61MP0002752_abnormal_somatic_nervous1.18963572
62MP0008872_abnormal_physiological_respon1.18728031
63MP0000955_abnormal_spinal_cord1.15091139
64MP0003755_abnormal_palate_morphology1.14960042
65MP0003011_delayed_dark_adaptation1.14759720
66MP0002882_abnormal_neuron_morphology1.13923013
67MP0001486_abnormal_startle_reflex1.11489494
68MP0003890_abnormal_embryonic-extraembry1.09884471
69MP0002735_abnormal_chemical_nociception1.09106513
70MP0005195_abnormal_posterior_eye1.08219044
71MP0003385_abnormal_body_wall1.05457531
72MP0004742_abnormal_vestibular_system1.02431631
73MP0004811_abnormal_neuron_physiology1.01906609
74MP0001970_abnormal_pain_threshold0.99930711
75MP0001529_abnormal_vocalization0.98102551
76MP0005389_reproductive_system_phenotype0.96268475
77MP0002152_abnormal_brain_morphology0.93598088
78MP0000026_abnormal_inner_ear0.93468651
79MP0001299_abnormal_eye_distance/0.93432131
80MP0009379_abnormal_foot_pigmentation0.92501838
81MP0005174_abnormal_tail_pigmentation0.92153500
82MP0001440_abnormal_grooming_behavior0.92002254
83MP0005391_vision/eye_phenotype0.91152760
84MP0005197_abnormal_uvea_morphology0.90974267
85MP0003861_abnormal_nervous_system0.90793752
86MP0003718_maternal_effect0.89623067
87MP0002067_abnormal_sensory_capabilities0.85744484
88MP0004215_abnormal_myocardial_fiber0.84362322
89MP0005386_behavior/neurological_phenoty0.83614639
90MP0004924_abnormal_behavior0.83614639
91MP0004145_abnormal_muscle_electrophysio0.82582732
92MP0002249_abnormal_larynx_morphology0.82143092
93MP0010030_abnormal_orbit_morphology0.80823561
94MP0008775_abnormal_heart_ventricle0.79788277
95MP0005670_abnormal_white_adipose0.79061554
96MP0003119_abnormal_digestive_system0.78948996
97MP0001324_abnormal_eye_pigmentation0.76787570
98MP0003122_maternal_imprinting0.76599069
99MP0009384_cardiac_valve_regurgitation0.76410131
100MP0001905_abnormal_dopamine_level0.71748102

Predicted human phenotypes

RankGene SetZ-score
1Gait imbalance (HP:0002141)5.05776253
2Congenital primary aphakia (HP:0007707)4.86497465
3Vaginal atresia (HP:0000148)4.45023623
4Medial flaring of the eyebrow (HP:0010747)4.42396559
5Nephrogenic diabetes insipidus (HP:0009806)4.40892395
6Genital tract atresia (HP:0001827)4.30242439
7Poor coordination (HP:0002370)4.19009221
8Pendular nystagmus (HP:0012043)3.77358903
9Anophthalmia (HP:0000528)3.07061949
10Type II lissencephaly (HP:0007260)2.95538999
11Septo-optic dysplasia (HP:0100842)2.83867512
12Hypoplasia of the pons (HP:0012110)2.82994812
13Chronic hepatic failure (HP:0100626)2.82213366
14Rib fusion (HP:0000902)2.74770474
15Bifid tongue (HP:0010297)2.74303431
16Decreased testicular size (HP:0008734)2.73730752
17Sclerocornea (HP:0000647)2.71463884
18Hyperglycinemia (HP:0002154)2.64877167
19Left ventricular hypertrophy (HP:0001712)2.64820843
20Thyroid-stimulating hormone excess (HP:0002925)2.63083396
21Abnormality of the pons (HP:0007361)2.59953727
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.58441903
23Lissencephaly (HP:0001339)2.56357144
24Broad foot (HP:0001769)2.56300062
25Molar tooth sign on MRI (HP:0002419)2.55221957
26Abnormality of midbrain morphology (HP:0002418)2.55221957
27Cutaneous finger syndactyly (HP:0010554)2.47593979
28Asplenia (HP:0001746)2.42782059
29Aplasia/Hypoplasia of the lens (HP:0008063)2.42594726
30Increased hepatocellular lipid droplets (HP:0006565)2.38033056
31Lipid accumulation in hepatocytes (HP:0006561)2.37413694
32Drooling (HP:0002307)2.37106750
33Cerebellar dysplasia (HP:0007033)2.32805508
34Cutaneous syndactyly (HP:0012725)2.32698856
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.31657937
36Delayed CNS myelination (HP:0002188)2.30306246
37Micropenis (HP:0000054)2.28308002
38Abnormality of renal resorption (HP:0011038)2.21485167
39Dental crowding (HP:0000678)2.20114508
40Hemivertebrae (HP:0002937)2.19010388
41Abnormal ciliary motility (HP:0012262)2.16319546
42Buphthalmos (HP:0000557)2.15441046
43Horseshoe kidney (HP:0000085)2.13432186
44Excessive salivation (HP:0003781)2.13423973
45Pancreatic fibrosis (HP:0100732)2.12893179
46Specific learning disability (HP:0001328)2.12537729
47Hyperventilation (HP:0002883)2.10904419
48Mesomelia (HP:0003027)2.10396049
49Renal Fanconi syndrome (HP:0001994)2.09617295
50True hermaphroditism (HP:0010459)2.09319207
51Pancreatic cysts (HP:0001737)2.07832798
52Chorioretinal atrophy (HP:0000533)2.07286137
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06796778
54Pachygyria (HP:0001302)2.04521138
55Proximal tubulopathy (HP:0000114)2.02185345
56Bicornuate uterus (HP:0000813)2.02103413
57Hepatoblastoma (HP:0002884)2.00250727
58Astigmatism (HP:0000483)1.99426160
59Postaxial hand polydactyly (HP:0001162)1.97742174
60Anencephaly (HP:0002323)1.96864566
61Focal motor seizures (HP:0011153)1.96497653
62Protruding tongue (HP:0010808)1.92080021
63Myokymia (HP:0002411)1.91690079
64Epileptic encephalopathy (HP:0200134)1.91182980
65Acute necrotizing encephalopathy (HP:0006965)1.90204472
66Retinitis pigmentosa (HP:0000510)1.90137642
67Meckel diverticulum (HP:0002245)1.88976875
68Absent septum pellucidum (HP:0001331)1.88703596
69Abnormality of lateral ventricle (HP:0030047)1.88127009
70Abnormality of the labia minora (HP:0012880)1.87912201
71Abnormal respiratory motile cilium physiology (HP:0012261)1.87897002
72Abnormality of the ileum (HP:0001549)1.87284498
73Ectopic kidney (HP:0000086)1.86113204
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.86040810
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85034716
76Megalencephaly (HP:0001355)1.84579750
77Acute encephalopathy (HP:0006846)1.83403653
78Short foot (HP:0001773)1.82354031
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79769926
80Abnormality of alanine metabolism (HP:0010916)1.79769926
81Hyperalaninemia (HP:0003348)1.79769926
82Aganglionic megacolon (HP:0002251)1.79214940
83Absent eyebrow (HP:0002223)1.79073871
84Abnormality of the phalanges of the 5th finger (HP:0004213)1.77847966
85Bilateral microphthalmos (HP:0007633)1.76652943
86Symphalangism affecting the phalanges of the hand (HP:0009773)1.76186106
87Partial agenesis of the corpus callosum (HP:0001338)1.76128700
88Aqueductal stenosis (HP:0002410)1.75929720
89Methylmalonic acidemia (HP:0002912)1.75241185
90IgA deficiency (HP:0002720)1.75221115
91Osteomalacia (HP:0002749)1.74321710
92Abolished electroretinogram (ERG) (HP:0000550)1.73795666
93Impaired vibration sensation in the lower limbs (HP:0002166)1.73502033
94Absent thumb (HP:0009777)1.72158065
95Poor suck (HP:0002033)1.71621330
96Impulsivity (HP:0100710)1.67871097
97Anterior segment dysgenesis (HP:0007700)1.67863067
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67736550
99Abnormality of the lacrimal duct (HP:0011481)1.65422925
100Abnormality of serum amino acid levels (HP:0003112)1.65366750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.42894594
2MAP4K24.40647080
3TNIK3.21609020
4STK393.18740871
5WNK43.16283333
6MARK12.97026534
7BCR2.71635538
8NME12.52425192
9MKNK22.35328021
10MINK12.29804258
11NTRK22.29427206
12DYRK22.20262110
13MAPK132.11602580
14MAP3K41.98628603
15MAP2K71.89044085
16BMPR1B1.80449456
17TYRO31.77214629
18RPS6KA41.59056077
19FRK1.56259993
20UHMK11.53277255
21EPHA31.51838232
22ZAK1.49146957
23CAMKK21.43455121
24CSNK1G21.42648301
25OXSR11.40402211
26PRKCG1.35426322
27CSNK1G31.28713139
28CSNK1A1L1.24945423
29TLK11.21012366
30CSNK1G11.20367163
31NUAK11.18553708
32MKNK11.12792552
33PINK11.04944708
34CAMK41.04714680
35CDC71.02302673
36GRK11.00152856
37ADRBK20.97488335
38SIK20.92999955
39WNK30.91594915
40EPHB20.89523568
41MARK30.88556887
42CDK50.88172130
43VRK10.87269405
44PRKD30.86485650
45BCKDK0.85615017
46CAMK1G0.79611820
47BRSK20.78597063
48CAMK1D0.77756935
49PRKCE0.77512611
50PNCK0.77469746
51CSNK1A10.76223435
52CAMKK10.75029357
53LATS10.72648444
54MAP3K90.71696777
55CDK190.71146245
56RPS6KA50.71051790
57CSNK1E0.70616296
58DYRK30.70012697
59PLK20.69861224
60PRKCH0.66608927
61CAMK2A0.66194952
62DAPK20.65671344
63STK160.64309471
64INSRR0.62648842
65WEE10.60226614
66TRIM280.58619026
67SGK20.57408006
68PRKCZ0.56679815
69CAMK10.56584123
70CAMK2B0.55574868
71ALK0.54579200
72SGK10.53197494
73PRKCI0.52536421
74CSNK1D0.51210844
75PLK40.50982591
76ERBB20.48743922
77TIE10.48079325
78MAP2K40.48021107
79PRKDC0.45900701
80MARK20.45843021
81ATM0.45624449
82NTRK30.42103633
83PRKACA0.41941993
84DYRK1A0.41373043
85CDK140.40787847
86SRPK10.40508077
87ERBB30.40321742
88PRKACB0.39949226
89PLK30.39865881
90SGK2230.39045544
91SGK4940.39045544
92GSK3B0.36340873
93CSNK2A20.35684535
94RPS6KA30.31355090
95CHEK20.31068873
96PRKCB0.30458815
97BMX0.30051269
98RPS6KA20.29523459
99MAPK90.28550966
100EIF2AK10.28299315

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.26068403
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.27690259
3Selenocompound metabolism_Homo sapiens_hsa004502.41566366
4Oxidative phosphorylation_Homo sapiens_hsa001902.32478408
5Protein export_Homo sapiens_hsa030602.15275466
6GABAergic synapse_Homo sapiens_hsa047272.14617982
7Parkinsons disease_Homo sapiens_hsa050122.08675992
8Ribosome_Homo sapiens_hsa030102.06494228
9Morphine addiction_Homo sapiens_hsa050321.97053302
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82884648
11Cardiac muscle contraction_Homo sapiens_hsa042601.81675282
12RNA polymerase_Homo sapiens_hsa030201.79608501
13Cocaine addiction_Homo sapiens_hsa050301.73210562
14Glutamatergic synapse_Homo sapiens_hsa047241.69466285
15Phototransduction_Homo sapiens_hsa047441.69050774
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64924421
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64617809
18Butanoate metabolism_Homo sapiens_hsa006501.60288637
19Huntingtons disease_Homo sapiens_hsa050161.57975756
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56399205
21Synaptic vesicle cycle_Homo sapiens_hsa047211.50914999
22Axon guidance_Homo sapiens_hsa043601.48801703
23Taste transduction_Homo sapiens_hsa047421.47951351
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45599236
25beta-Alanine metabolism_Homo sapiens_hsa004101.43620253
26Alcoholism_Homo sapiens_hsa050341.43478727
27Vitamin B6 metabolism_Homo sapiens_hsa007501.42929971
28Mismatch repair_Homo sapiens_hsa034301.42156200
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39141509
30Alzheimers disease_Homo sapiens_hsa050101.37568303
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36380773
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29193874
33RNA degradation_Homo sapiens_hsa030181.28331347
34Hedgehog signaling pathway_Homo sapiens_hsa043401.17429995
35Olfactory transduction_Homo sapiens_hsa047401.16884699
36Fatty acid biosynthesis_Homo sapiens_hsa000611.11293085
37Basal cell carcinoma_Homo sapiens_hsa052171.11183037
38Amphetamine addiction_Homo sapiens_hsa050311.08760264
39Vitamin digestion and absorption_Homo sapiens_hsa049771.05404783
40Steroid biosynthesis_Homo sapiens_hsa001001.02917211
41Insulin secretion_Homo sapiens_hsa049111.00846773
42Nitrogen metabolism_Homo sapiens_hsa009101.00716518
43Fanconi anemia pathway_Homo sapiens_hsa034600.99957739
44Pyruvate metabolism_Homo sapiens_hsa006200.96902983
45Collecting duct acid secretion_Homo sapiens_hsa049660.93936349
46Linoleic acid metabolism_Homo sapiens_hsa005910.92098983
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88858621
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87821110
49Basal transcription factors_Homo sapiens_hsa030220.87519177
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87076309
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85631745
52Dopaminergic synapse_Homo sapiens_hsa047280.84217724
53Circadian entrainment_Homo sapiens_hsa047130.83077701
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82580666
55Systemic lupus erythematosus_Homo sapiens_hsa053220.82301714
56Propanoate metabolism_Homo sapiens_hsa006400.79654617
57One carbon pool by folate_Homo sapiens_hsa006700.78502342
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75247534
59RNA transport_Homo sapiens_hsa030130.72984473
60Cholinergic synapse_Homo sapiens_hsa047250.72304618
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72227680
62Salivary secretion_Homo sapiens_hsa049700.71543616
63Spliceosome_Homo sapiens_hsa030400.69624357
64Serotonergic synapse_Homo sapiens_hsa047260.65525295
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63645053
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.62287867
67Homologous recombination_Homo sapiens_hsa034400.62025027
68cAMP signaling pathway_Homo sapiens_hsa040240.61451716
69mRNA surveillance pathway_Homo sapiens_hsa030150.60261597
70Hippo signaling pathway_Homo sapiens_hsa043900.57841296
71Proteasome_Homo sapiens_hsa030500.57485588
72DNA replication_Homo sapiens_hsa030300.57058385
73Tryptophan metabolism_Homo sapiens_hsa003800.52959492
74Ether lipid metabolism_Homo sapiens_hsa005650.50298251
75Wnt signaling pathway_Homo sapiens_hsa043100.48707156
76Purine metabolism_Homo sapiens_hsa002300.46511389
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46194125
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45540143
79Arginine and proline metabolism_Homo sapiens_hsa003300.45422753
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44872603
81Pyrimidine metabolism_Homo sapiens_hsa002400.43791350
82Gastric acid secretion_Homo sapiens_hsa049710.41163570
83Mineral absorption_Homo sapiens_hsa049780.40667794
84Retinol metabolism_Homo sapiens_hsa008300.38358464
85Melanoma_Homo sapiens_hsa052180.37818944
86Caffeine metabolism_Homo sapiens_hsa002320.37573667
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36686590
88Oxytocin signaling pathway_Homo sapiens_hsa049210.35909243
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34918391
90Peroxisome_Homo sapiens_hsa041460.34614195
91Chemical carcinogenesis_Homo sapiens_hsa052040.34012452
92Ras signaling pathway_Homo sapiens_hsa040140.33118203
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32970197
94Metabolic pathways_Homo sapiens_hsa011000.29391741
95Folate biosynthesis_Homo sapiens_hsa007900.29284308
96Notch signaling pathway_Homo sapiens_hsa043300.28441405
97Calcium signaling pathway_Homo sapiens_hsa040200.27802699
98Sulfur relay system_Homo sapiens_hsa041220.27729201
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26019790
100Long-term depression_Homo sapiens_hsa047300.25867501

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