NOP58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.66223946
2nuclear pore complex assembly (GO:0051292)4.64685718
3maturation of SSU-rRNA (GO:0030490)4.53602589
4protein localization to kinetochore (GO:0034501)4.44839599
5DNA replication initiation (GO:0006270)4.34838133
6mitotic metaphase plate congression (GO:0007080)4.33053187
7DNA unwinding involved in DNA replication (GO:0006268)4.25986322
8proteasome assembly (GO:0043248)4.16259576
9DNA strand elongation involved in DNA replication (GO:0006271)4.14203613
10DNA replication-dependent nucleosome organization (GO:0034723)4.13076629
11DNA replication-dependent nucleosome assembly (GO:0006335)4.13076629
12ribosome assembly (GO:0042255)4.09984415
13chromatin remodeling at centromere (GO:0031055)4.08676269
14ribosomal large subunit biogenesis (GO:0042273)4.07795298
15DNA replication checkpoint (GO:0000076)4.04601071
16CENP-A containing nucleosome assembly (GO:0034080)4.01671834
17nucleobase biosynthetic process (GO:0046112)4.01328416
18kinetochore organization (GO:0051383)3.99981265
19DNA strand elongation (GO:0022616)3.95126001
20ribosome biogenesis (GO:0042254)3.90172068
21ribosomal small subunit assembly (GO:0000028)3.88914316
22telomere maintenance via semi-conservative replication (GO:0032201)3.87318735
23ribonucleoprotein complex biogenesis (GO:0022613)3.87195802
24mitotic nuclear envelope disassembly (GO:0007077)3.84879606
25metaphase plate congression (GO:0051310)3.82563908
26IMP biosynthetic process (GO:0006188)3.81734869
27purine nucleobase biosynthetic process (GO:0009113)3.79924813
28establishment of integrated proviral latency (GO:0075713)3.78682736
29protein localization to chromosome, centromeric region (GO:0071459)3.78269634
30translational termination (GO:0006415)3.78115414
31rRNA modification (GO:0000154)3.77890263
32viral transcription (GO:0019083)3.77228114
33formation of translation preinitiation complex (GO:0001731)3.74484574
34ribosomal small subunit biogenesis (GO:0042274)3.73071360
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70113560
36DNA replication-independent nucleosome organization (GO:0034724)3.67118738
37DNA replication-independent nucleosome assembly (GO:0006336)3.67118738
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.66538889
39DNA double-strand break processing (GO:0000729)3.66315005
40pore complex assembly (GO:0046931)3.62085396
41telomere maintenance via recombination (GO:0000722)3.59597605
42mitotic recombination (GO:0006312)3.56686238
43membrane disassembly (GO:0030397)3.56451070
44nuclear envelope disassembly (GO:0051081)3.56451070
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53732171
46kinetochore assembly (GO:0051382)3.51245802
47* rRNA processing (GO:0006364)3.50903740
48histone exchange (GO:0043486)3.50746005
49translational initiation (GO:0006413)3.50599168
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49554295
51mitotic sister chromatid segregation (GO:0000070)3.49178838
52DNA catabolic process, exonucleolytic (GO:0000738)3.47435903
53spliceosomal snRNP assembly (GO:0000387)3.45030649
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.44743827
55folic acid-containing compound biosynthetic process (GO:0009396)3.44667091
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44432988
57negative regulation of mRNA processing (GO:0050686)3.42923013
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.41747093
59* rRNA metabolic process (GO:0016072)3.41168222
60regulation of DNA endoreduplication (GO:0032875)3.40981423
61DNA ligation (GO:0006266)3.39504857
62transcription from mitochondrial promoter (GO:0006390)3.39248702
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39220013
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39159977
65telomere maintenance via telomere lengthening (GO:0010833)3.37506385
66regulation of spindle organization (GO:0090224)3.36913870
67protein K6-linked ubiquitination (GO:0085020)3.36509767
68rRNA methylation (GO:0031167)3.36434158
69negative regulation of RNA splicing (GO:0033119)3.34876646
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34776086
71negative regulation of ligase activity (GO:0051352)3.34243155
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34243155
73IMP metabolic process (GO:0046040)3.32808206
74mitotic sister chromatid cohesion (GO:0007064)3.32190141
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31857555
76translational elongation (GO:0006414)3.31447913
77sister chromatid segregation (GO:0000819)3.31302307
78establishment of chromosome localization (GO:0051303)3.30430787
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30012307
80replication fork processing (GO:0031297)3.28413393
81regulation of helicase activity (GO:0051095)3.27977263
82mitotic chromosome condensation (GO:0007076)3.26773748
83DNA duplex unwinding (GO:0032508)3.26354825
84attachment of spindle microtubules to kinetochore (GO:0008608)3.25916660
85DNA geometric change (GO:0032392)3.25673992
86chaperone-mediated protein transport (GO:0072321)3.25186546
87maturation of 5.8S rRNA (GO:0000460)3.23173206
88mitochondrial RNA metabolic process (GO:0000959)3.20780276
89histone mRNA metabolic process (GO:0008334)3.19828067
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18188879
91regulation of mitotic spindle checkpoint (GO:1903504)3.18188879
92termination of RNA polymerase II transcription (GO:0006369)3.17316966
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16939488
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.16939488
95meiotic chromosome segregation (GO:0045132)3.16781910
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.16544775
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15093711
98regulation of centrosome cycle (GO:0046605)3.13880252
99spindle checkpoint (GO:0031577)3.13845860
100positive regulation of chromosome segregation (GO:0051984)3.13404710
101spliceosomal complex assembly (GO:0000245)3.12850816
102negative regulation of mRNA metabolic process (GO:1903312)3.10774218
103chromatin assembly or disassembly (GO:0006333)3.10693681
104transcription elongation from RNA polymerase III promoter (GO:0006385)3.09370822
105termination of RNA polymerase III transcription (GO:0006386)3.09370822
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08706575
107mitochondrial respiratory chain complex assembly (GO:0033108)3.07218380
108regulation of nuclear cell cycle DNA replication (GO:0033262)3.05989292
109cellular component biogenesis (GO:0044085)3.05675485
110non-recombinational repair (GO:0000726)3.05363905
111double-strand break repair via nonhomologous end joining (GO:0006303)3.05363905
112mitochondrial respiratory chain complex I assembly (GO:0032981)3.03728705
113NADH dehydrogenase complex assembly (GO:0010257)3.03728705
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03728705
115cellular protein complex disassembly (GO:0043624)3.03030554
116DNA-templated transcription, termination (GO:0006353)3.02220264
117negative regulation of chromosome segregation (GO:0051985)3.01322074
118cotranslational protein targeting to membrane (GO:0006613)3.00883380
119regulation of centriole replication (GO:0046599)3.00521989
120regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00087669
121protein targeting to ER (GO:0045047)3.00014564
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.99717981
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99717981
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99717981
125negative regulation of sister chromatid segregation (GO:0033046)2.99717981
126regulation of histone H3-K9 methylation (GO:0051570)2.99702256
127spindle assembly checkpoint (GO:0071173)2.98837651
128RNA splicing, via transesterification reactions (GO:0000375)2.98344093
129regulation of chromosome segregation (GO:0051983)2.98060206
130mitotic spindle checkpoint (GO:0071174)2.98024758
131regulation of mitotic spindle organization (GO:0060236)2.97300797
132mRNA splicing, via spliceosome (GO:0000398)2.95790684
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.95790684
134ATP-dependent chromatin remodeling (GO:0043044)2.94220627
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92840697
136viral life cycle (GO:0019058)2.91216516
137mitotic spindle assembly checkpoint (GO:0007094)2.91142631
138intra-S DNA damage checkpoint (GO:0031573)2.90554458
139negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90350419
140viral mRNA export from host cell nucleus (GO:0046784)2.89724160
141pseudouridine synthesis (GO:0001522)2.89317244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.73686093
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57421668
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.43220306
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27963629
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34159739
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31097046
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03424844
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97219121
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96280436
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.88397694
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69705474
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.65476279
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60690115
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54039838
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47918865
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46266117
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42642669
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37006097
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35135427
20* XRN2_22483619_ChIP-Seq_HELA_Human2.32932525
21AR_21909140_ChIP-Seq_LNCAP_Human2.28938956
22* VDR_23849224_ChIP-Seq_CD4+_Human2.22323328
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22028406
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20041960
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.18867443
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.09187589
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00645960
28* TTF2_22483619_ChIP-Seq_HELA_Human1.94464261
29FOXP3_21729870_ChIP-Seq_TREG_Human1.94341616
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92603230
31ELK1_19687146_ChIP-ChIP_HELA_Human1.91527517
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88395846
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86770204
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83862360
35DCP1A_22483619_ChIP-Seq_HELA_Human1.83194246
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.82714957
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76409971
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73314989
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72676138
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71459950
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70912972
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64501241
43GABP_19822575_ChIP-Seq_HepG2_Human1.63582647
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61560422
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60114167
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56047116
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55912573
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.55257271
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48953288
50EWS_26573619_Chip-Seq_HEK293_Human1.47847917
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47684291
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46144856
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45420070
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45275840
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42416235
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41977978
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41530031
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41030325
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40056918
60KDM5A_27292631_Chip-Seq_BREAST_Human1.37694029
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36797394
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32736661
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32444196
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31877137
65CIITA_25753668_ChIP-Seq_RAJI_Human1.31600896
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29991368
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29991368
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29991368
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.27461033
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.26422990
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25914325
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25212558
73MYC_22102868_ChIP-Seq_BL_Human1.24808648
74ZNF274_21170338_ChIP-Seq_K562_Hela1.21395438
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21207580
76VDR_22108803_ChIP-Seq_LS180_Human1.19535188
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.17572040
78FUS_26573619_Chip-Seq_HEK293_Human1.15645441
79MYC_18940864_ChIP-ChIP_HL60_Human1.10039886
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09580501
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09524322
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07566324
83* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07445120
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06033477
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04697850
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03674446
87IRF1_19129219_ChIP-ChIP_H3396_Human1.02602451
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02188316
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01609595
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99146325
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.98961730
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95898931
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94801242
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94765632
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94417875
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92964019
97TFEB_21752829_ChIP-Seq_HELA_Human0.92211915
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87791008
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87629478
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87323128
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87157784
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86648679
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85252989
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85193880
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83057193
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.82804772
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.81058996
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80222529
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.79348946
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77287157
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76311935
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75253155
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74655918
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.74127045
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71892444
116ELF5_23300383_ChIP-Seq_T47D_Human0.70557848
117IGF1R_20145208_ChIP-Seq_DFB_Human0.70520577
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.70039127
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68115238
120TAF15_26573619_Chip-Seq_HEK293_Human0.64181542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12900962
2MP0010094_abnormal_chromosome_stability4.80312548
3MP0003111_abnormal_nucleus_morphology4.42307635
4MP0004957_abnormal_blastocyst_morpholog4.29798308
5MP0008057_abnormal_DNA_replication4.27256907
6MP0003077_abnormal_cell_cycle3.87180148
7MP0008058_abnormal_DNA_repair3.49078393
8MP0008007_abnormal_cellular_replicative2.77167915
9MP0008932_abnormal_embryonic_tissue2.67721466
10MP0003123_paternal_imprinting2.60395039
11MP0009697_abnormal_copulation2.34580856
12MP0008877_abnormal_DNA_methylation2.34368355
13MP0003806_abnormal_nucleotide_metabolis2.29030387
14MP0002396_abnormal_hematopoietic_system2.26633821
15MP0000350_abnormal_cell_proliferation2.26467212
16MP0003786_premature_aging2.25505384
17MP0001730_embryonic_growth_arrest2.24348190
18MP0010352_gastrointestinal_tract_polyps2.19450206
19MP0010307_abnormal_tumor_latency2.10460666
20MP0001672_abnormal_embryogenesis/_devel1.77468891
21MP0005380_embryogenesis_phenotype1.77468891
22MP0006035_abnormal_mitochondrial_morpho1.73039597
23MP0001697_abnormal_embryo_size1.69215719
24MP0003941_abnormal_skin_development1.66641245
25MP0006036_abnormal_mitochondrial_physio1.65402459
26MP0003121_genomic_imprinting1.64697571
27MP0002085_abnormal_embryonic_tissue1.63184339
28MP0002084_abnormal_developmental_patter1.61486035
29MP0006072_abnormal_retinal_apoptosis1.60829159
30MP0004197_abnormal_fetal_growth/weight/1.59440565
31MP0000490_abnormal_crypts_of1.58898199
32MP0003984_embryonic_growth_retardation1.54119959
33MP0003718_maternal_effect1.52170635
34MP0002088_abnormal_embryonic_growth/wei1.51215294
35MP0002080_prenatal_lethality1.50929023
36MP0004808_abnormal_hematopoietic_stem1.48936687
37MP0001293_anophthalmia1.42066887
38MP0002086_abnormal_extraembryonic_tissu1.42020076
39MP0008995_early_reproductive_senescence1.41170697
40MP0003890_abnormal_embryonic-extraembry1.40502011
41MP0004147_increased_porphyrin_level1.40282550
42MP0003186_abnormal_redox_activity1.39725774
43MP0002210_abnormal_sex_determination1.36934083
44MP0000313_abnormal_cell_death1.36858914
45MP0001188_hyperpigmentation1.35007118
46MP0003567_abnormal_fetal_cardiomyocyte1.34842470
47MP0010030_abnormal_orbit_morphology1.30472081
48MP0005076_abnormal_cell_differentiation1.25037465
49MP0002019_abnormal_tumor_incidence1.24383800
50MP0005379_endocrine/exocrine_gland_phen1.23400312
51MP0003315_abnormal_perineum_morphology1.22934169
52MP0001145_abnormal_male_reproductive1.19440409
53MP0006292_abnormal_olfactory_placode1.16224155
54MP0003937_abnormal_limbs/digits/tail_de1.15978317
55MP0003136_yellow_coat_color1.15686339
56MP0001529_abnormal_vocalization1.13688840
57MP0000372_irregular_coat_pigmentation1.11013425
58MP0001929_abnormal_gametogenesis1.07396170
59MP0005075_abnormal_melanosome_morpholog1.05945080
60MP0000653_abnormal_sex_gland1.03412071
61MP0001853_heart_inflammation1.02272548
62MP0000703_abnormal_thymus_morphology1.00937378
63MP0002111_abnormal_tail_morphology1.00095074
64MP0003119_abnormal_digestive_system0.99977335
65MP0002138_abnormal_hepatobiliary_system0.98316841
66MP0002160_abnormal_reproductive_system0.96386975
67MP0005084_abnormal_gallbladder_morpholo0.95725655
68MP0001286_abnormal_eye_development0.94838509
69MP0002102_abnormal_ear_morphology0.93564420
70MP0009053_abnormal_anal_canal0.93418501
71MP0009379_abnormal_foot_pigmentation0.89421672
72MP0003763_abnormal_thymus_physiology0.88323334
73MP0004133_heterotaxia0.86531338
74MP0009333_abnormal_splenocyte_physiolog0.85320144
75MP0000537_abnormal_urethra_morphology0.85047246
76MP0005389_reproductive_system_phenotype0.84936738
77MP0008872_abnormal_physiological_respon0.84684820
78MP0000432_abnormal_head_morphology0.83691322
79MP0002006_tumorigenesis0.83628064
80MP0000428_abnormal_craniofacial_morphol0.82736785
81MP0005397_hematopoietic_system_phenotyp0.81299831
82MP0001545_abnormal_hematopoietic_system0.81299831
83MP0001119_abnormal_female_reproductive0.79382708
84MP0009672_abnormal_birth_weight0.79320125
85MP0002938_white_spotting0.79067962
86MP0000566_synostosis0.78872825
87MP0009703_decreased_birth_body0.78527988
88MP0002092_abnormal_eye_morphology0.78389933
89MP0003787_abnormal_imprinting0.76380373
90MP0001764_abnormal_homeostasis0.76252087
91MP0002132_abnormal_respiratory_system0.72112577
92MP0002722_abnormal_immune_system0.71171557
93MP0003755_abnormal_palate_morphology0.70977620
94MP0002398_abnormal_bone_marrow0.70360515
95MP0002697_abnormal_eye_size0.69494660
96MP0000858_altered_metastatic_potential0.67070877
97MP0002095_abnormal_skin_pigmentation0.66170984
98MP0002751_abnormal_autonomic_nervous0.66075013
99MP0008789_abnormal_olfactory_epithelium0.65839104
100MP0005384_cellular_phenotype0.65763309
101MP0000049_abnormal_middle_ear0.64858738
102MP0002653_abnormal_ependyma_morphology0.64417940
103MP0003936_abnormal_reproductive_system0.64367475
104MP0000627_abnormal_mammary_gland0.64302760
105MP0005395_other_phenotype0.64239715
106MP0002114_abnormal_axial_skeleton0.64213572
107MP0005023_abnormal_wound_healing0.64107423
108MP0002736_abnormal_nociception_after0.64079461
109MP0002166_altered_tumor_susceptibility0.63585573
110MP0001919_abnormal_reproductive_system0.62815410
111MP0001881_abnormal_mammary_gland0.62658174
112MP0002009_preneoplasia0.62433367
113MP0004215_abnormal_myocardial_fiber0.62379565
114MP0003935_abnormal_craniofacial_develop0.62226035
115MP0005220_abnormal_exocrine_pancreas0.61533475
116MP0000689_abnormal_spleen_morphology0.60964866
117MP0005253_abnormal_eye_physiology0.60005355
118MP0005621_abnormal_cell_physiology0.59842205
119MP0003698_abnormal_male_reproductive0.59731745
120MP0002254_reproductive_system_inflammat0.59725179
121MP0000613_abnormal_salivary_gland0.59668596
122MP0003861_abnormal_nervous_system0.58733622
123MP0001915_intracranial_hemorrhage0.57898083
124MP0003699_abnormal_female_reproductive0.57824420
125MP0002277_abnormal_respiratory_mucosa0.57697814
126MP0003448_altered_tumor_morphology0.57423212
127MP0003938_abnormal_ear_development0.57335225
128MP0002163_abnormal_gland_morphology0.57014316
129MP0000631_abnormal_neuroendocrine_gland0.55742604
130MP0000358_abnormal_cell_content/0.55604270
131MP0000477_abnormal_intestine_morphology0.54865704
132MP0004264_abnormal_extraembryonic_tissu0.54836506
133MP0000647_abnormal_sebaceous_gland0.54808680
134MP0008873_increased_physiological_sensi0.54307099
135MP0005408_hypopigmentation0.53993909
136MP0002161_abnormal_fertility/fecundity0.52741223

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.57005392
2Chromsome breakage (HP:0040012)4.48768757
3Reticulocytopenia (HP:0001896)4.44346950
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22386678
5Breast hypoplasia (HP:0003187)3.55377408
6Acute necrotizing encephalopathy (HP:0006965)3.52898334
7Abnormality of the labia minora (HP:0012880)3.50067974
8Abnormality of chromosome stability (HP:0003220)3.44271296
9Abnormality of the preputium (HP:0100587)3.39844077
10Abnormality of cells of the erythroid lineage (HP:0012130)3.38027107
11Colon cancer (HP:0003003)3.33303626
12Increased CSF lactate (HP:0002490)3.32099208
13Patellar aplasia (HP:0006443)3.31410723
14Meckel diverticulum (HP:0002245)3.29721893
15Medulloblastoma (HP:0002885)3.26904918
16Acute encephalopathy (HP:0006846)3.21315946
17Abnormal mitochondria in muscle tissue (HP:0008316)3.19300169
18Mitochondrial inheritance (HP:0001427)3.17311148
19Increased hepatocellular lipid droplets (HP:0006565)3.14281101
20Aplasia/Hypoplasia of the patella (HP:0006498)3.12682419
21Abnormality of the ileum (HP:0001549)3.12037370
22Ependymoma (HP:0002888)3.08735061
23Abnormal number of erythroid precursors (HP:0012131)3.07127226
24Absent radius (HP:0003974)3.06394826
25Selective tooth agenesis (HP:0001592)3.02397654
26Hepatocellular necrosis (HP:0001404)3.00386010
27Oral leukoplakia (HP:0002745)2.96350970
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.96117275
29Progressive macrocephaly (HP:0004481)2.94121245
30Impulsivity (HP:0100710)2.92710318
31Absent forearm bone (HP:0003953)2.87021930
32Aplasia involving forearm bones (HP:0009822)2.87021930
33Supernumerary spleens (HP:0009799)2.83760674
34Lipid accumulation in hepatocytes (HP:0006561)2.83410416
35Absent thumb (HP:0009777)2.81326595
36Increased serum lactate (HP:0002151)2.72431354
37Carpal bone hypoplasia (HP:0001498)2.69829349
38Hepatic necrosis (HP:0002605)2.68934376
39Macrocytic anemia (HP:0001972)2.68163644
40Pallor (HP:0000980)2.67623669
41Myelodysplasia (HP:0002863)2.67341331
42Rough bone trabeculation (HP:0100670)2.64056804
43Pancytopenia (HP:0001876)2.60323236
44Rhabdomyosarcoma (HP:0002859)2.60158363
45Small intestinal stenosis (HP:0012848)2.59602539
46Duodenal stenosis (HP:0100867)2.59602539
47Cerebral edema (HP:0002181)2.58841995
48Agnosia (HP:0010524)2.55927489
4911 pairs of ribs (HP:0000878)2.52622299
50Premature graying of hair (HP:0002216)2.50898300
51Ectopic kidney (HP:0000086)2.49532547
52Neoplasm of the pancreas (HP:0002894)2.46120878
53Horseshoe kidney (HP:0000085)2.45701957
54Abnormal number of incisors (HP:0011064)2.45227961
55Duplicated collecting system (HP:0000081)2.43672183
56Abnormality of methionine metabolism (HP:0010901)2.41346653
57Microvesicular hepatic steatosis (HP:0001414)2.39446934
58Volvulus (HP:0002580)2.37343966
59Abnormality of the anterior horn cell (HP:0006802)2.35904742
60Degeneration of anterior horn cells (HP:0002398)2.35904742
61Methylmalonic acidemia (HP:0002912)2.35807868
62Type I transferrin isoform profile (HP:0003642)2.35794358
63Abnormality of alanine metabolism (HP:0010916)2.35700532
64Hyperalaninemia (HP:0003348)2.35700532
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35700532
66Triphalangeal thumb (HP:0001199)2.34507382
67Proximal placement of thumb (HP:0009623)2.32426632
68Sloping forehead (HP:0000340)2.30300663
69Reduced antithrombin III activity (HP:0001976)2.28951588
70Aplastic anemia (HP:0001915)2.27374035
71Bone marrow hypocellularity (HP:0005528)2.26085381
72Squamous cell carcinoma (HP:0002860)2.26077974
73Deviation of the thumb (HP:0009603)2.26008965
74Atresia of the external auditory canal (HP:0000413)2.22563595
75Neoplasm of the oral cavity (HP:0100649)2.22456839
76Lactic acidosis (HP:0003128)2.21663302
77Basal cell carcinoma (HP:0002671)2.20804271
78Abnormality of the duodenum (HP:0002246)2.16252737
79Pancreatic cysts (HP:0001737)2.14965789
80Short thumb (HP:0009778)2.14561579
81Cerebral hypomyelination (HP:0006808)2.14499347
82Abnormality of the pons (HP:0007361)2.13412057
83Abnormal lung lobation (HP:0002101)2.13258020
84Tracheoesophageal fistula (HP:0002575)2.12016203
85Increased nuchal translucency (HP:0010880)2.11979289
86Hypoplasia of the pons (HP:0012110)2.11644923
87Amaurosis fugax (HP:0100576)2.11340348
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11313107
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11313107
90Nephroblastoma (Wilms tumor) (HP:0002667)2.09724677
91Abnormality of the renal collecting system (HP:0004742)2.08945839
92Glioma (HP:0009733)2.07998181
93Abnormality of serum amino acid levels (HP:0003112)2.07346813
94Abnormality of the carotid arteries (HP:0005344)2.06448044
95Megaloblastic anemia (HP:0001889)2.05567389
963-Methylglutaconic aciduria (HP:0003535)2.05343718
97Sparse lateral eyebrow (HP:0005338)2.04876565
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04846777
99Astrocytoma (HP:0009592)2.03854047
100Abnormality of the astrocytes (HP:0100707)2.03854047
101Pendular nystagmus (HP:0012043)2.03546430
102Congenital, generalized hypertrichosis (HP:0004540)2.02479514
103Leukodystrophy (HP:0002415)2.02142413
104Biliary tract neoplasm (HP:0100574)2.01263470
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01137513
106Abnormal trabecular bone morphology (HP:0100671)2.00797178
107Methylmalonic aciduria (HP:0012120)2.00719977
108Pancreatic fibrosis (HP:0100732)1.99104537
109Missing ribs (HP:0000921)1.99016472
110Trismus (HP:0000211)1.97418243
111Embryonal renal neoplasm (HP:0011794)1.96945234
112Multiple enchondromatosis (HP:0005701)1.96807147
113Abnormality of DNA repair (HP:0003254)1.96547823
114Increased serum pyruvate (HP:0003542)1.95582349
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94611072
116Abnormal protein glycosylation (HP:0012346)1.94476166
117Abnormal glycosylation (HP:0012345)1.94476166
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94476166
119Abnormal protein N-linked glycosylation (HP:0012347)1.94476166
120Increased intramyocellular lipid droplets (HP:0012240)1.91796591
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.90849160
122Facial hemangioma (HP:0000329)1.90004776
123Clubbing of toes (HP:0100760)1.87881239
124Renal Fanconi syndrome (HP:0001994)1.87550304
125Prominent nose (HP:0000448)1.86130488
126Neoplasm of striated muscle (HP:0009728)1.85533765
127Cellular immunodeficiency (HP:0005374)1.85410555
128Aplasia/hypoplasia of the humerus (HP:0006507)1.83760474
129Cleft eyelid (HP:0000625)1.82671945
130Hypoplasia of the radius (HP:0002984)1.82349091
131Rib fusion (HP:0000902)1.82263231
132Supernumerary bones of the axial skeleton (HP:0009144)1.81820738
133Respiratory failure (HP:0002878)1.81198944
134Facial cleft (HP:0002006)1.79931211
135Cafe-au-lait spot (HP:0000957)1.79495580
136Abnormality of abdominal situs (HP:0011620)1.79473984
137Abdominal situs inversus (HP:0003363)1.79473984
138Exercise intolerance (HP:0003546)1.78521142
139Lymphoma (HP:0002665)1.76013011
140Hyperglycinemia (HP:0002154)1.74904333
141Gonadotropin excess (HP:0000837)1.74647241
142True hermaphroditism (HP:0010459)1.74393928
143Lethargy (HP:0001254)1.73755157
144Exertional dyspnea (HP:0002875)1.73041660
145Glossoptosis (HP:0000162)1.71245775
146Neoplasm of the colon (HP:0100273)1.71016035
147Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69505024
148Secondary amenorrhea (HP:0000869)1.68866611
149Premature ovarian failure (HP:0008209)1.68429126
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67182085
151Choanal atresia (HP:0000453)1.65804397
152Supernumerary ribs (HP:0005815)1.65472341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.40551227
2CDC74.38432552
3BUB13.96501282
4SRPK13.29889135
5EIF2AK13.07707819
6VRK22.94142691
7MKNK12.71247770
8TLK12.68973720
9TSSK62.65902249
10MKNK22.64695500
11CDK122.48641287
12NEK22.47645463
13TTK2.43660172
14PLK42.39824072
15EPHA22.35612301
16BRSK22.14736271
17PLK12.02621713
18TAF11.97841610
19PLK31.88416612
20VRK11.88141385
21CDK71.81321594
22AURKB1.79782691
23ATR1.78030181
24EIF2AK31.75503932
25RPS6KB21.74196540
26ACVR1B1.71164299
27NME21.71037803
28NEK11.70025560
29ZAK1.69888735
30PASK1.67923966
31CHEK21.62194080
32STK161.59076536
33BRD41.53225999
34PNCK1.52887066
35TRIM281.52651638
36CHEK11.45481735
37DYRK31.41904636
38RPS6KA41.28388031
39TESK21.23634661
40CDK41.22551324
41AURKA1.17136267
42ATM1.14960960
43MAP3K81.14693104
44BMPR1B1.09388404
45BRSK11.06884676
46STK41.02229042
47PDK21.01247215
48ALK1.00612304
49WNK30.99557559
50STK100.99437908
51EIF2AK20.97981897
52CDK20.97464858
53TNIK0.91529491
54PIM10.90786168
55CSNK2A20.85237055
56EEF2K0.83658631
57RPS6KA50.76796631
58CDK10.76531505
59PBK0.75927943
60CDK80.75888802
61STK30.74471658
62CDK60.74266291
63CCNB10.73684662
64TGFBR10.72788507
65SCYL20.72747453
66INSRR0.71428621
67FRK0.70826277
68PAK40.70745157
69CSNK2A10.68591206
70PLK20.67821151
71MELK0.62697407
72OXSR10.61330864
73CSNK1E0.59422690
74AKT30.58459673
75PRKCI0.58052335
76GRK10.58020920
77PIM20.57471060
78MAP4K20.56728686
79LATS10.55157092
80STK390.54370447
81PAK10.53788441
82STK38L0.51863947
83CSNK1G10.50485199
84PRKDC0.49007899
85BCR0.48576499
86ADRBK20.45174811
87MAP3K100.45061344
88PAK20.42070111
89LATS20.40978304
90YES10.40976012
91CSNK1D0.40759325
92MST40.40031503
93BCKDK0.39893320
94MTOR0.39549294
95MAPK140.38625462
96NME10.37440446
97DAPK10.35997161
98AKT20.32366347
99FLT30.30303045
100WNK40.29527177
101CDK190.28649838
102CSNK1A1L0.28260654
103TEC0.27824874
104MAP3K120.27473375
105NUAK10.26810942
106ERBB40.26423286
107IKBKB0.25763390
108AKT10.25127914
109GSK3B0.24924242
110CSNK1G20.24613059
111MAPKAPK50.24052516
112BRAF0.23366800
113CDK90.23182708
114FGFR10.22858323
115CLK10.22402410
116MAPK10.19477014
117DYRK20.18868261
118MARK30.17420571
119LRRK20.15605099
120CDK30.15374543
121MAP4K10.15229431
122ERBB30.13267858
123RPS6KB10.12542688
124TXK0.12246919
125MAPK90.11673935
126CSNK1G30.10815976
127PKN20.10558598

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52903154
2Mismatch repair_Homo sapiens_hsa034304.15863779
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14060572
4Spliceosome_Homo sapiens_hsa030403.59380279
5Ribosome_Homo sapiens_hsa030103.57351874
6RNA transport_Homo sapiens_hsa030133.33938726
7RNA polymerase_Homo sapiens_hsa030203.30109608
8Homologous recombination_Homo sapiens_hsa034403.17620466
9Nucleotide excision repair_Homo sapiens_hsa034202.85528445
10Cell cycle_Homo sapiens_hsa041102.78155555
11Proteasome_Homo sapiens_hsa030502.70307356
12Fanconi anemia pathway_Homo sapiens_hsa034602.65599661
13Base excision repair_Homo sapiens_hsa034102.61463797
14One carbon pool by folate_Homo sapiens_hsa006702.60323244
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51993767
16Non-homologous end-joining_Homo sapiens_hsa034502.40995804
17Pyrimidine metabolism_Homo sapiens_hsa002402.30149324
18Basal transcription factors_Homo sapiens_hsa030222.26351716
19Oxidative phosphorylation_Homo sapiens_hsa001902.12622781
20RNA degradation_Homo sapiens_hsa030182.07428274
21Parkinsons disease_Homo sapiens_hsa050122.03046905
22mRNA surveillance pathway_Homo sapiens_hsa030152.01397773
23Systemic lupus erythematosus_Homo sapiens_hsa053221.86881473
24p53 signaling pathway_Homo sapiens_hsa041151.76886328
25Purine metabolism_Homo sapiens_hsa002301.28400843
26Epstein-Barr virus infection_Homo sapiens_hsa051691.23486996
27Propanoate metabolism_Homo sapiens_hsa006401.21206758
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15373421
29Viral carcinogenesis_Homo sapiens_hsa052031.14597237
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13331237
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11824776
32Alzheimers disease_Homo sapiens_hsa050101.11047756
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09596324
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03370528
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99767242
36Antigen processing and presentation_Homo sapiens_hsa046120.98189471
37Herpes simplex infection_Homo sapiens_hsa051680.96814447
38Pyruvate metabolism_Homo sapiens_hsa006200.96464613
39Oocyte meiosis_Homo sapiens_hsa041140.93828798
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91586849
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85113007
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82721694
43HTLV-I infection_Homo sapiens_hsa051660.82308200
44MicroRNAs in cancer_Homo sapiens_hsa052060.81847778
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77556307
46Alcoholism_Homo sapiens_hsa050340.77461900
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71443057
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67880547
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67662283
50Fatty acid elongation_Homo sapiens_hsa000620.66432393
51Small cell lung cancer_Homo sapiens_hsa052220.66325105
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63515763
53Vitamin B6 metabolism_Homo sapiens_hsa007500.61190241
54Protein export_Homo sapiens_hsa030600.60359835
55TGF-beta signaling pathway_Homo sapiens_hsa043500.57585536
56Basal cell carcinoma_Homo sapiens_hsa052170.55734731
57Selenocompound metabolism_Homo sapiens_hsa004500.54816488
58Pentose phosphate pathway_Homo sapiens_hsa000300.53695481
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.53078221
60Thyroid cancer_Homo sapiens_hsa052160.52059868
61Steroid biosynthesis_Homo sapiens_hsa001000.51980185
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.51821546
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51395138
64Hippo signaling pathway_Homo sapiens_hsa043900.50469151
65Folate biosynthesis_Homo sapiens_hsa007900.49684756
66Primary immunodeficiency_Homo sapiens_hsa053400.47642839
67Huntingtons disease_Homo sapiens_hsa050160.44841173
68Notch signaling pathway_Homo sapiens_hsa043300.44527107
69Carbon metabolism_Homo sapiens_hsa012000.44208488
70Legionellosis_Homo sapiens_hsa051340.44170515
71Caffeine metabolism_Homo sapiens_hsa002320.42655667
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42154148
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.40405427
74Colorectal cancer_Homo sapiens_hsa052100.40322734
75Apoptosis_Homo sapiens_hsa042100.39024177
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38603816
77Phototransduction_Homo sapiens_hsa047440.37257303
78Vitamin digestion and absorption_Homo sapiens_hsa049770.36828201
79Measles_Homo sapiens_hsa051620.36762101
80Hedgehog signaling pathway_Homo sapiens_hsa043400.36641850
81Hepatitis B_Homo sapiens_hsa051610.36539696
82Biosynthesis of amino acids_Homo sapiens_hsa012300.35281206
83Cardiac muscle contraction_Homo sapiens_hsa042600.35083535
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.35051260
85Butanoate metabolism_Homo sapiens_hsa006500.33880411
86N-Glycan biosynthesis_Homo sapiens_hsa005100.33784316
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33761449
88Peroxisome_Homo sapiens_hsa041460.33744737
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33274979
90Sulfur relay system_Homo sapiens_hsa041220.32630453
91Pathways in cancer_Homo sapiens_hsa052000.32338049
92Bladder cancer_Homo sapiens_hsa052190.31419365
93Wnt signaling pathway_Homo sapiens_hsa043100.29968646
94Hematopoietic cell lineage_Homo sapiens_hsa046400.29882196
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28418756
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27752444
97Prostate cancer_Homo sapiens_hsa052150.25536626
98Regulation of autophagy_Homo sapiens_hsa041400.25437940
99Allograft rejection_Homo sapiens_hsa053300.23641741
100Nitrogen metabolism_Homo sapiens_hsa009100.23117440
101Glutathione metabolism_Homo sapiens_hsa004800.23072507
102Asthma_Homo sapiens_hsa053100.22654777
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22641762
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.22630962
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22593571
106Renin-angiotensin system_Homo sapiens_hsa046140.22312042
107Chronic myeloid leukemia_Homo sapiens_hsa052200.21753313
108Adherens junction_Homo sapiens_hsa045200.21724651
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21445635
110Viral myocarditis_Homo sapiens_hsa054160.21144111
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.20448583
112Melanoma_Homo sapiens_hsa052180.19849754
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19620721
114Sulfur metabolism_Homo sapiens_hsa009200.19311433
115HIF-1 signaling pathway_Homo sapiens_hsa040660.19026493
116Influenza A_Homo sapiens_hsa051640.18954775
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18284033
118Tryptophan metabolism_Homo sapiens_hsa003800.18032707
119Fatty acid metabolism_Homo sapiens_hsa012120.17853102
120Autoimmune thyroid disease_Homo sapiens_hsa053200.17449188
121Type I diabetes mellitus_Homo sapiens_hsa049400.16696179
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.15529664
123Fatty acid degradation_Homo sapiens_hsa000710.15270855
124Tight junction_Homo sapiens_hsa045300.14049284
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13577636
126Graft-versus-host disease_Homo sapiens_hsa053320.11758861
127mTOR signaling pathway_Homo sapiens_hsa041500.10993092
128Shigellosis_Homo sapiens_hsa051310.10336860
129FoxO signaling pathway_Homo sapiens_hsa040680.10236326
130T cell receptor signaling pathway_Homo sapiens_hsa046600.09653660
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08599838
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.08535635
133Acute myeloid leukemia_Homo sapiens_hsa052210.08252260
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08043344
135Lysine degradation_Homo sapiens_hsa003100.07891126
136Retinol metabolism_Homo sapiens_hsa008300.07797443
137Metabolic pathways_Homo sapiens_hsa011000.07237031

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