NOS1AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08920813
2synaptic vesicle exocytosis (GO:0016079)5.82702817
3vocalization behavior (GO:0071625)5.57169516
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56693118
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.44904376
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43827526
7glutamate secretion (GO:0014047)5.39752080
8synaptic vesicle maturation (GO:0016188)5.28426364
9locomotory exploration behavior (GO:0035641)5.09854062
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09233002
11regulation of glutamate receptor signaling pathway (GO:1900449)5.03482438
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.89284912
13glutamate receptor signaling pathway (GO:0007215)4.88330541
14protein localization to synapse (GO:0035418)4.87702172
15neuronal action potential propagation (GO:0019227)4.84439636
16synaptic transmission, glutamatergic (GO:0035249)4.82596338
17neuron cell-cell adhesion (GO:0007158)4.71388962
18regulation of synaptic vesicle exocytosis (GO:2000300)4.66014734
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52167298
20regulation of neuronal synaptic plasticity (GO:0048168)4.52151001
21neuron-neuron synaptic transmission (GO:0007270)4.51703718
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45367204
23exploration behavior (GO:0035640)4.24878084
24regulation of synaptic vesicle transport (GO:1902803)4.24631333
25long-term memory (GO:0007616)4.20254304
26neurotransmitter secretion (GO:0007269)4.17345515
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.08903445
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05140270
29sodium ion export (GO:0071436)4.04143200
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96381792
31regulation of synapse structural plasticity (GO:0051823)3.92967404
32pyrimidine nucleobase catabolic process (GO:0006208)3.88131155
33positive regulation of synapse maturation (GO:0090129)3.85516366
34regulation of postsynaptic membrane potential (GO:0060078)3.85333838
35neuronal ion channel clustering (GO:0045161)3.82836534
36neuron recognition (GO:0008038)3.82746266
37regulation of synaptic plasticity (GO:0048167)3.82445455
38gamma-aminobutyric acid transport (GO:0015812)3.81174707
39dendritic spine morphogenesis (GO:0060997)3.79964447
40cerebellar granule cell differentiation (GO:0021707)3.79139858
41neurotransmitter-gated ion channel clustering (GO:0072578)3.78069715
42positive regulation of membrane potential (GO:0045838)3.76146768
43regulation of dendritic spine morphogenesis (GO:0061001)3.73264424
44synaptic vesicle endocytosis (GO:0048488)3.73057294
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70873707
46layer formation in cerebral cortex (GO:0021819)3.69168941
47transmission of nerve impulse (GO:0019226)3.67472542
48innervation (GO:0060384)3.67060644
49L-amino acid import (GO:0043092)3.63266852
50long-term synaptic potentiation (GO:0060291)3.61894906
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.59688575
52regulation of vesicle fusion (GO:0031338)3.59474031
53behavioral fear response (GO:0001662)3.59079691
54behavioral defense response (GO:0002209)3.59079691
55auditory behavior (GO:0031223)3.59053821
56axonal fasciculation (GO:0007413)3.57513443
57cell migration in hindbrain (GO:0021535)3.54358004
58positive regulation of neurotransmitter secretion (GO:0001956)3.51916645
59neurotransmitter transport (GO:0006836)3.50325931
60activation of protein kinase A activity (GO:0034199)3.49763224
61cellular potassium ion homeostasis (GO:0030007)3.48425091
62central nervous system myelination (GO:0022010)3.46150153
63axon ensheathment in central nervous system (GO:0032291)3.46150153
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43426444
65proline transport (GO:0015824)3.42581814
66amino acid import (GO:0043090)3.40276205
67establishment of mitochondrion localization (GO:0051654)3.38213287
68regulation of neurotransmitter secretion (GO:0046928)3.37868824
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.35991190
70membrane depolarization (GO:0051899)3.33163872
71regulation of neurotransmitter levels (GO:0001505)3.32846367
72startle response (GO:0001964)3.32769607
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32081348
74fear response (GO:0042596)3.32008613
75positive regulation of neurotransmitter transport (GO:0051590)3.29775467
76postsynaptic membrane organization (GO:0001941)3.29523555
77response to auditory stimulus (GO:0010996)3.28772176
78regulation of dendritic spine development (GO:0060998)3.28048532
79response to histamine (GO:0034776)3.26135375
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25999744
81neuromuscular synaptic transmission (GO:0007274)3.25614263
82dendritic spine organization (GO:0097061)3.23879603
83behavioral response to cocaine (GO:0048148)3.23259515
84membrane depolarization during action potential (GO:0086010)3.21809212
85cerebellar Purkinje cell differentiation (GO:0021702)3.21688609
86presynaptic membrane assembly (GO:0097105)3.20786035
87nucleobase catabolic process (GO:0046113)3.20228534
88positive regulation of synapse assembly (GO:0051965)3.18018355
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17728569
90regulation of glutamate secretion (GO:0014048)3.15945629
91learning (GO:0007612)3.15908683
92mechanosensory behavior (GO:0007638)3.15610218
93synaptic transmission (GO:0007268)3.15506147
94regulation of neurotransmitter transport (GO:0051588)3.14200960
95regulation of synapse maturation (GO:0090128)3.13746853
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12702037
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12288436
98positive regulation of dendritic spine development (GO:0060999)3.12166634
99long term synaptic depression (GO:0060292)3.08729428
100chemosensory behavior (GO:0007635)3.08362411
101regulation of synaptic transmission (GO:0050804)3.06703102
102presynaptic membrane organization (GO:0097090)3.06363819
103cell communication by electrical coupling (GO:0010644)3.01207106
104neuromuscular process controlling balance (GO:0050885)3.00553075
105dendrite morphogenesis (GO:0048813)3.00013389
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99223301
107establishment of synaptic vesicle localization (GO:0097480)2.98743899
108synaptic vesicle transport (GO:0048489)2.98743899
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.98598913
110synapse assembly (GO:0007416)2.97540928
111neurofilament cytoskeleton organization (GO:0060052)2.96168381
112regulation of voltage-gated calcium channel activity (GO:1901385)2.95851881
113cellular sodium ion homeostasis (GO:0006883)2.95611183
114acidic amino acid transport (GO:0015800)2.94988458
115membrane hyperpolarization (GO:0060081)2.94763289
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94145162
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93314046
118cochlea development (GO:0090102)2.92577613
119neuromuscular process controlling posture (GO:0050884)2.92565328
120adult walking behavior (GO:0007628)2.90133243
121synapse organization (GO:0050808)2.84180595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97623776
2GBX2_23144817_ChIP-Seq_PC3_Human3.93365142
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21777294
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20620520
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10854291
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74753839
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74753839
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73211889
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70043446
10REST_21632747_ChIP-Seq_MESCs_Mouse2.61490343
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60445118
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53650321
13DROSHA_22980978_ChIP-Seq_HELA_Human2.53162859
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50027018
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.48441886
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43748669
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.41474589
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.39411541
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.37612956
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18718077
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17134413
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.16238691
23TAF15_26573619_Chip-Seq_HEK293_Human2.10214879
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.05627105
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97312476
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94201437
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89788701
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85794183
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76786351
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.71266541
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70910163
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69815566
33AR_21572438_ChIP-Seq_LNCaP_Human1.69755896
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69302885
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68310276
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59448292
37P300_19829295_ChIP-Seq_ESCs_Human1.55783434
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52185697
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45643015
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45204776
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44776283
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42455544
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.40458593
44ZNF274_21170338_ChIP-Seq_K562_Hela1.40301648
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.38842162
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36421336
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34516050
48AR_25329375_ChIP-Seq_VCAP_Human1.33904414
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33168032
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.29833393
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.29813195
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28511681
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27402361
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23431030
55IGF1R_20145208_ChIP-Seq_DFB_Human1.22203397
56STAT3_23295773_ChIP-Seq_U87_Human1.21767189
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.20935932
58FUS_26573619_Chip-Seq_HEK293_Human1.20819730
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.20063160
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20062142
61* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19167806
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16339964
63TP53_16413492_ChIP-PET_HCT116_Human1.15892490
64* AR_19668381_ChIP-Seq_PC3_Human1.14736908
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13272238
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12939696
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12027078
68TCF4_23295773_ChIP-Seq_U87_Human1.11239161
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10914327
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10478251
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.09829413
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07926810
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07390617
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07344796
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06684650
76RNF2_27304074_Chip-Seq_NSC_Mouse1.06485457
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.05576911
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05184437
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05016679
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04247644
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02187060
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02003601
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01438425
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01438425
85RUNX2_22187159_ChIP-Seq_PCA_Human1.00636903
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00501485
87VDR_22108803_ChIP-Seq_LS180_Human1.00373841
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00139989
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99613051
90AHR_22903824_ChIP-Seq_MCF-7_Human0.99389871
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.99341719
92JUN_21703547_ChIP-Seq_K562_Human0.99266251
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97733700
94BCAT_22108803_ChIP-Seq_LS180_Human0.96649125
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96599489
96* TP53_18474530_ChIP-ChIP_U2OS_Human0.96110820
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95831795
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95684901
99* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95258084
100* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95080391
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94613133
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.94518733
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94206883
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93519558
105* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93149020
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92963139
107SOX9_26525672_Chip-Seq_HEART_Mouse0.92328618
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89551938
109KDM2B_26808549_Chip-Seq_K562_Human0.89456863
110* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87951451
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.87449240
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.87372709
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87226709
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.87169312
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86152527
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86079467
117* CTCF_27219007_Chip-Seq_Bcells_Human0.85796225
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85719132
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85425150
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84642010
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84333540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.08454527
2MP0003880_abnormal_central_pattern5.69724776
3MP0003635_abnormal_synaptic_transmissio4.33995109
4MP0009745_abnormal_behavioral_response3.69343044
5MP0002063_abnormal_learning/memory/cond3.46985200
6MP0004270_analgesia3.40312471
7MP0002064_seizures3.36386341
8MP0001968_abnormal_touch/_nociception3.23836951
9MP0009046_muscle_twitch3.18523135
10MP0002572_abnormal_emotion/affect_behav2.95454457
11MP0002736_abnormal_nociception_after2.80383197
12MP0002272_abnormal_nervous_system2.69354384
13MP0001486_abnormal_startle_reflex2.64612025
14MP0001501_abnormal_sleep_pattern2.58430476
15MP0002735_abnormal_chemical_nociception2.45027129
16MP0002822_catalepsy2.45000416
17MP0002734_abnormal_mechanical_nocicepti2.36523923
18MP0005423_abnormal_somatic_nervous2.29082396
19MP0001440_abnormal_grooming_behavior2.22359648
20MP0002067_abnormal_sensory_capabilities2.01370860
21MP0002733_abnormal_thermal_nociception1.98108396
22MP0001970_abnormal_pain_threshold1.94947595
23MP0006276_abnormal_autonomic_nervous1.76925284
24MP0002557_abnormal_social/conspecific_i1.76157665
25MP0008569_lethality_at_weaning1.73122646
26MP0001529_abnormal_vocalization1.70139505
27MP0003329_amyloid_beta_deposits1.69757874
28MP0003879_abnormal_hair_cell1.69443354
29MP0002184_abnormal_innervation1.67828459
30MP0001905_abnormal_dopamine_level1.67021113
31MP0000778_abnormal_nervous_system1.66161949
32MP0004924_abnormal_behavior1.66045948
33MP0005386_behavior/neurological_phenoty1.66045948
34MP0005646_abnormal_pituitary_gland1.63727865
35MP0003787_abnormal_imprinting1.57177440
36MP0004811_abnormal_neuron_physiology1.56709750
37MP0009780_abnormal_chondrocyte_physiolo1.53003570
38MP0002909_abnormal_adrenal_gland1.43392886
39MP0001188_hyperpigmentation1.39719726
40MP0001984_abnormal_olfaction1.38358619
41MP0002066_abnormal_motor_capabilities/c1.37436763
42MP0004142_abnormal_muscle_tone1.37288380
43MP0004858_abnormal_nervous_system1.37188337
44MP0000955_abnormal_spinal_cord1.33488237
45MP0003122_maternal_imprinting1.30294642
46MP0002882_abnormal_neuron_morphology1.28723140
47MP0003633_abnormal_nervous_system1.24914918
48MP0001502_abnormal_circadian_rhythm1.24061700
49MP0008872_abnormal_physiological_respon1.18343141
50MP0002638_abnormal_pupillary_reflex1.15357360
51MP0002653_abnormal_ependyma_morphology1.12425529
52MP0005409_darkened_coat_color1.12090100
53MP0004145_abnormal_muscle_electrophysio1.10407367
54MP0002837_dystrophic_cardiac_calcinosis1.10333261
55MP0003631_nervous_system_phenotype1.08815207
56MP0000566_synostosis1.07905367
57MP0003123_paternal_imprinting1.07882163
58MP0004885_abnormal_endolymph1.06582748
59MP0008874_decreased_physiological_sensi1.06102726
60MP0000751_myopathy1.05282132
61MP0002876_abnormal_thyroid_physiology1.00999184
62MP0005645_abnormal_hypothalamus_physiol1.00287382
63MP0002152_abnormal_brain_morphology0.98818582
64MP0004510_myositis0.98683504
65MP0003861_abnormal_nervous_system0.98151578
66MP0008877_abnormal_DNA_methylation0.94853750
67MP0003938_abnormal_ear_development0.91746890
68MP0005535_abnormal_body_temperature0.91549545
69MP0004484_altered_response_of0.89818637
70MP0002069_abnormal_eating/drinking_beha0.89687347
71MP0001963_abnormal_hearing_physiology0.87909910
72MP0008789_abnormal_olfactory_epithelium0.87400542
73MP0001177_atelectasis0.87181681
74MP0003075_altered_response_to0.86231123
75MP0004085_abnormal_heartbeat0.85843769
76MP0004215_abnormal_myocardial_fiber0.84164796
77MP0004742_abnormal_vestibular_system0.83417215
78MP0005187_abnormal_penis_morphology0.82927833
79MP0001664_abnormal_digestion0.81943827
80MP0010386_abnormal_urinary_bladder0.81400071
81MP0003136_yellow_coat_color0.81263328
82MP0002229_neurodegeneration0.80978351
83MP0002249_abnormal_larynx_morphology0.80452843
84MP0004133_heterotaxia0.80089198
85MP0000049_abnormal_middle_ear0.79143913
86MP0003632_abnormal_nervous_system0.78143527
87MP0010234_abnormal_vibrissa_follicle0.77972423
88MP0008961_abnormal_basal_metabolism0.75760542
89MP0005551_abnormal_eye_electrophysiolog0.74960482
90MP0000604_amyloidosis0.74718055
91MP0003119_abnormal_digestive_system0.71026660
92MP0005167_abnormal_blood-brain_barrier0.70037398
93MP0006292_abnormal_olfactory_placode0.68947681
94MP0000631_abnormal_neuroendocrine_gland0.67730850
95MP0000920_abnormal_myelination0.67516414
96MP0001485_abnormal_pinna_reflex0.66954803
97MP0003690_abnormal_glial_cell0.66399842
98MP0002090_abnormal_vision0.65952849
99MP0002752_abnormal_somatic_nervous0.64920726
100MP0001299_abnormal_eye_distance/0.64318040
101MP0002102_abnormal_ear_morphology0.61008455
102MP0003890_abnormal_embryonic-extraembry0.59805076
103MP0001986_abnormal_taste_sensitivity0.59362878
104MP0000569_abnormal_digit_pigmentation0.59113191
105MP0001943_abnormal_respiration0.58889322
106MP0010768_mortality/aging0.58024864
107MP0000026_abnormal_inner_ear0.56842347
108MP0002081_perinatal_lethality0.56782608
109MP0003634_abnormal_glial_cell0.56118031
110MP0002234_abnormal_pharynx_morphology0.55958746
111MP0000579_abnormal_nail_morphology0.55743602
112MP0005499_abnormal_olfactory_system0.54908087
113MP0005394_taste/olfaction_phenotype0.54908087
114MP0003137_abnormal_impulse_conducting0.54512045
115MP0002233_abnormal_nose_morphology0.53374999
116MP0003121_genomic_imprinting0.49824454
117MP0005171_absent_coat_pigmentation0.48160256
118MP0005623_abnormal_meninges_morphology0.48050335
119MP0010769_abnormal_survival0.47938644
120MP0001765_abnormal_ion_homeostasis0.47163821
121MP0010770_preweaning_lethality0.46449036
122MP0002082_postnatal_lethality0.46449036
123MP0003956_abnormal_body_size0.46383665

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.58221012
2Myokymia (HP:0002411)7.57973029
3Focal seizures (HP:0007359)6.49276435
4Visual hallucinations (HP:0002367)5.94150562
5Epileptic encephalopathy (HP:0200134)5.33266765
6Febrile seizures (HP:0002373)5.30159082
7Atonic seizures (HP:0010819)5.22939571
8Progressive cerebellar ataxia (HP:0002073)4.98284588
9Absence seizures (HP:0002121)4.54675062
10Generalized tonic-clonic seizures (HP:0002069)4.45464964
11Dialeptic seizures (HP:0011146)4.24011611
12Gaze-evoked nystagmus (HP:0000640)3.73275411
13Broad-based gait (HP:0002136)3.70935509
14Hyperventilation (HP:0002883)3.52955556
15Dysmetria (HP:0001310)3.46988543
16Impaired vibration sensation in the lower limbs (HP:0002166)3.43442655
17Amblyopia (HP:0000646)3.42377158
18Action tremor (HP:0002345)3.35931584
19Poor eye contact (HP:0000817)3.24334847
20Anxiety (HP:0000739)3.14559157
21Dysdiadochokinesis (HP:0002075)3.12536732
22Supranuclear gaze palsy (HP:0000605)3.12003384
23Depression (HP:0000716)3.10301220
24Genetic anticipation (HP:0003743)3.08917708
25Limb dystonia (HP:0002451)3.03781762
26Progressive inability to walk (HP:0002505)2.95870315
27Urinary bladder sphincter dysfunction (HP:0002839)2.90023033
28Truncal ataxia (HP:0002078)2.84935065
29Abnormal eating behavior (HP:0100738)2.84166946
30Impaired social interactions (HP:0000735)2.83728656
31Abnormal social behavior (HP:0012433)2.83728656
32Scanning speech (HP:0002168)2.80423164
33Diplopia (HP:0000651)2.76492911
34Abnormality of binocular vision (HP:0011514)2.76492911
35Excessive salivation (HP:0003781)2.74388734
36Drooling (HP:0002307)2.74388734
37Hemiparesis (HP:0001269)2.72351619
38Cerebral inclusion bodies (HP:0100314)2.71847376
39Impaired smooth pursuit (HP:0007772)2.68787244
40Epileptiform EEG discharges (HP:0011182)2.67789601
41Postural instability (HP:0002172)2.66217973
42Ankle clonus (HP:0011448)2.65625279
43Absent speech (HP:0001344)2.58988459
44Status epilepticus (HP:0002133)2.57775064
45Mutism (HP:0002300)2.57387936
46Hemiplegia (HP:0002301)2.52718541
47Focal dystonia (HP:0004373)2.50606883
48Spastic gait (HP:0002064)2.49629044
49Inability to walk (HP:0002540)2.49569827
50Stereotypic behavior (HP:0000733)2.49523736
51Cerebral hypomyelination (HP:0006808)2.49099350
52Split foot (HP:0001839)2.48249582
53Papilledema (HP:0001085)2.47579057
54Bradykinesia (HP:0002067)2.44556673
55Neurofibrillary tangles (HP:0002185)2.42996979
56Abnormality of the lower motor neuron (HP:0002366)2.41558710
57Abnormality of the corticospinal tract (HP:0002492)2.38299394
58EEG with generalized epileptiform discharges (HP:0011198)2.37212685
59Impaired vibratory sensation (HP:0002495)2.35933660
60Torticollis (HP:0000473)2.35411433
61Generalized myoclonic seizures (HP:0002123)2.32452327
62Sleep apnea (HP:0010535)2.29613150
63Urinary urgency (HP:0000012)2.28283164
64Abnormality of ocular smooth pursuit (HP:0000617)2.28074350
65Incomplete penetrance (HP:0003829)2.27042086
66Polyphagia (HP:0002591)2.19429977
67Hypsarrhythmia (HP:0002521)2.18417128
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.17349074
69Absent/shortened dynein arms (HP:0200106)2.17349074
70Fetal akinesia sequence (HP:0001989)2.13375711
71Apathy (HP:0000741)2.13305828
72Ventricular fibrillation (HP:0001663)2.12561016
73Intention tremor (HP:0002080)2.11195870
74Megalencephaly (HP:0001355)2.09667053
75Psychosis (HP:0000709)2.09328710
76Dysmetric saccades (HP:0000641)2.07549902
77Delusions (HP:0000746)2.05902161
78Morphological abnormality of the pyramidal tract (HP:0002062)2.04420186
79Bronchomalacia (HP:0002780)2.04300755
80Blue irides (HP:0000635)2.03633049
81Specific learning disability (HP:0001328)2.02658093
82Gait ataxia (HP:0002066)2.01819173
83Abnormality of the labia minora (HP:0012880)1.99109549
84Craniofacial dystonia (HP:0012179)1.98973366
85Decreased circulating renin level (HP:0003351)1.98211823
86Agitation (HP:0000713)1.97738140
87Peripheral hypomyelination (HP:0007182)1.97016211
88Akinesia (HP:0002304)1.93421115
89Spastic tetraparesis (HP:0001285)1.93208350
90Amyotrophic lateral sclerosis (HP:0007354)1.93106543
91Diminished motivation (HP:0000745)1.90729040
92Abnormality of salivation (HP:0100755)1.90244580
93Dyskinesia (HP:0100660)1.89533528
94Abnormal ciliary motility (HP:0012262)1.88497519
95Generalized hypopigmentation of hair (HP:0011358)1.88358997
96Protruding tongue (HP:0010808)1.88234539
97Spastic tetraplegia (HP:0002510)1.88016228
98Fair hair (HP:0002286)1.87568663
99Genital tract atresia (HP:0001827)1.86562970
100Optic nerve hypoplasia (HP:0000609)1.86155717
101Annular pancreas (HP:0001734)1.84671013
102Rapidly progressive (HP:0003678)1.83898712
103Thickened helices (HP:0000391)1.83668923
104Ulnar claw (HP:0001178)1.83009490
105Lower limb muscle weakness (HP:0007340)1.82639128
106Vaginal atresia (HP:0000148)1.81208002
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.79575434
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79575434
109Hypoplasia of the corpus callosum (HP:0002079)1.79489386
110Rigidity (HP:0002063)1.78794482
111Septo-optic dysplasia (HP:0100842)1.78348071
112Hepatoblastoma (HP:0002884)1.77752524
113Abnormal EKG (HP:0003115)1.77479614
114Neuronal loss in central nervous system (HP:0002529)1.76149521
115Inappropriate behavior (HP:0000719)1.75875875
116Retinal dysplasia (HP:0007973)1.75825964
117Confusion (HP:0001289)1.75599022
118Termporal pattern (HP:0011008)1.75191880
119Insidious onset (HP:0003587)1.75191880
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74836116
121Hypoplasia of the brainstem (HP:0002365)1.74836116
122Increased circulating renin level (HP:0000848)1.73619626
123Widely spaced teeth (HP:0000687)1.72263552
124Gastroesophageal reflux (HP:0002020)1.71540342
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71496369
126Pheochromocytoma (HP:0002666)1.70965675
127Syncope (HP:0001279)1.70564652
128Gait imbalance (HP:0002141)1.70345514
129Obstructive sleep apnea (HP:0002870)1.69805647
130Clonus (HP:0002169)1.69543783
131Insomnia (HP:0100785)1.68673518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.52289772
2NTRK34.94007036
3MAP3K93.45768266
4RIPK43.00132613
5MAP3K42.91620463
6MAP2K72.76941792
7MAP3K122.71866468
8MINK12.41216326
9DAPK22.35396710
10TNIK2.17004146
11MAP2K42.10939258
12NTRK21.98926999
13KSR21.92193983
14PAK61.86630421
15PLK21.83838251
16CASK1.81233590
17FES1.78630829
18ARAF1.77828996
19DAPK11.77391633
20MARK11.76038785
21KSR11.68726295
22CDK191.61610298
23MAP3K131.60808745
24GRK51.56957293
25PNCK1.51962666
26CDK51.50103030
27CAMKK11.44327542
28SIK21.36924188
29MAPK131.34108251
30BMPR21.30331185
31PRKCG1.29212786
32NTRK11.27372740
33CAMK2A1.21938318
34WNK31.21743262
35PRKD31.21570440
36BCR1.21093968
37PTK2B1.17118489
38DYRK21.14362025
39CAMK2B1.13104366
40NME11.11675342
41CAMK11.09712595
42RAF11.09320718
43STK381.08564170
44CSNK1G20.94534356
45PRPF4B0.92867621
46OXSR10.89956919
47LMTK20.89340433
48FGR0.87844886
49CDK180.87719106
50FER0.85692666
51CDK150.84916941
52PKN10.84590703
53MAP3K60.83837586
54STK110.81931716
55CAMKK20.78116233
56MAP3K20.77061942
57UHMK10.76370685
58MARK20.76288136
59CDK140.76238643
60CDK11A0.74719297
61DYRK1A0.72611029
62PDK10.72083750
63SGK2230.68908399
64SGK4940.68908399
65SGK10.67925626
66CSNK1A1L0.67570810
67TYRO30.66783492
68RET0.64521703
69ICK0.63708316
70PINK10.62650072
71MAPKAPK50.62649989
72CAMK2D0.61954085
73PAK30.61495660
74TNK20.59752118
75RIPK10.59643743
76BRAF0.56976265
77PDPK10.56191487
78PRKCE0.56119158
79MAP3K10.56048764
80WNK10.55592611
81SGK20.54682105
82CAMK2G0.54275223
83ERBB20.52557992
84PRKCH0.52159394
85SIK30.51774883
86ALK0.51741062
87CSNK1G10.51321720
88LATS20.50703321
89CSNK1E0.50433146
90INSRR0.50300170
91MUSK0.48992712
92BRSK10.48577635
93TRIM280.48360925
94GRK70.48351131
95TAOK10.47518665
96CAMK1G0.47444539
97NEK60.47093864
98CSNK1D0.45460204
99MAP3K70.44651036
100MOS0.42252721
101FYN0.40885595
102CAMK40.40529923
103PRKCZ0.40274636
104PHKG10.39657669
105PHKG20.39657669
106CCNB10.39200243
107ADRBK20.39095780
108GSK3B0.38709690
109PRKG10.38562006
110ROCK20.38111067
111CSNK1A10.38061490
112RPS6KA30.37414846
113STK390.37090775
114PRKACB0.36861724
115DAPK30.36569667
116FGFR20.36482713
117DMPK0.36440026
118MAPK80.36402552
119CAMK1D0.35157576
120SGK30.34336556
121MAP2K10.33958985
122EPHB20.33871147
123PRKDC0.33591050
124WNK40.33367732
125MAPK100.32807191
126GRK60.32126145
127CSNK1G30.31868205
128NEK10.30595565
129PRKACA0.29723883

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15248895
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29538627
3Long-term potentiation_Homo sapiens_hsa047202.95150040
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93964275
5* Circadian entrainment_Homo sapiens_hsa047132.85341102
6Glutamatergic synapse_Homo sapiens_hsa047242.76618392
7Amphetamine addiction_Homo sapiens_hsa050312.76176280
8GABAergic synapse_Homo sapiens_hsa047272.72757603
9Olfactory transduction_Homo sapiens_hsa047402.64130492
10Morphine addiction_Homo sapiens_hsa050322.61241398
11Salivary secretion_Homo sapiens_hsa049702.37217038
12Dopaminergic synapse_Homo sapiens_hsa047282.19655524
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10311624
14Insulin secretion_Homo sapiens_hsa049112.02351568
15Taste transduction_Homo sapiens_hsa047421.96501433
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95137402
17Gastric acid secretion_Homo sapiens_hsa049711.92970557
18Cholinergic synapse_Homo sapiens_hsa047251.89010873
19Calcium signaling pathway_Homo sapiens_hsa040201.85132506
20Serotonergic synapse_Homo sapiens_hsa047261.84374492
21Long-term depression_Homo sapiens_hsa047301.80822401
22Collecting duct acid secretion_Homo sapiens_hsa049661.77600081
23Renin secretion_Homo sapiens_hsa049241.70969728
24Oxytocin signaling pathway_Homo sapiens_hsa049211.69397959
25Cocaine addiction_Homo sapiens_hsa050301.67059819
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53233077
27GnRH signaling pathway_Homo sapiens_hsa049121.47716964
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35659887
29cAMP signaling pathway_Homo sapiens_hsa040241.34996249
30Gap junction_Homo sapiens_hsa045401.33790384
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33170405
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27598042
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20833798
34Vitamin B6 metabolism_Homo sapiens_hsa007501.20565684
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13587202
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11459425
37Cardiac muscle contraction_Homo sapiens_hsa042601.10564327
38Type II diabetes mellitus_Homo sapiens_hsa049301.07476149
39Melanogenesis_Homo sapiens_hsa049161.07443486
40Estrogen signaling pathway_Homo sapiens_hsa049151.06454787
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.03854909
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02718246
43Vibrio cholerae infection_Homo sapiens_hsa051101.01420309
44Axon guidance_Homo sapiens_hsa043600.99149440
45Glioma_Homo sapiens_hsa052140.95509740
46Pancreatic secretion_Homo sapiens_hsa049720.93806404
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93427102
48ErbB signaling pathway_Homo sapiens_hsa040120.91367671
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90516123
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90357921
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89787508
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85320542
53Alzheimers disease_Homo sapiens_hsa050100.83277896
54Thyroid hormone synthesis_Homo sapiens_hsa049180.80504487
55Oxidative phosphorylation_Homo sapiens_hsa001900.77556277
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74983282
57Oocyte meiosis_Homo sapiens_hsa041140.74739455
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.73374157
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72381074
60Choline metabolism in cancer_Homo sapiens_hsa052310.72327096
61Phototransduction_Homo sapiens_hsa047440.71796697
62African trypanosomiasis_Homo sapiens_hsa051430.70874535
63Dilated cardiomyopathy_Homo sapiens_hsa054140.68299914
64Dorso-ventral axis formation_Homo sapiens_hsa043200.67713730
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66320645
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63923767
67Butanoate metabolism_Homo sapiens_hsa006500.63326389
68Hippo signaling pathway_Homo sapiens_hsa043900.62312931
69MAPK signaling pathway_Homo sapiens_hsa040100.57193228
70VEGF signaling pathway_Homo sapiens_hsa043700.57010383
71Tight junction_Homo sapiens_hsa045300.55934108
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53809891
73Ras signaling pathway_Homo sapiens_hsa040140.53561013
74Rap1 signaling pathway_Homo sapiens_hsa040150.53224723
75Parkinsons disease_Homo sapiens_hsa050120.53102369
76Fatty acid biosynthesis_Homo sapiens_hsa000610.52569187
77Bile secretion_Homo sapiens_hsa049760.50922989
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49849154
79Glucagon signaling pathway_Homo sapiens_hsa049220.48888648
80Arginine and proline metabolism_Homo sapiens_hsa003300.46057939
81Inositol phosphate metabolism_Homo sapiens_hsa005620.46043777
82Ovarian steroidogenesis_Homo sapiens_hsa049130.44202297
83beta-Alanine metabolism_Homo sapiens_hsa004100.43518208
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42023433
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.41964676
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.41580541
87AMPK signaling pathway_Homo sapiens_hsa041520.40583859
88Hedgehog signaling pathway_Homo sapiens_hsa043400.40116918
89Wnt signaling pathway_Homo sapiens_hsa043100.39126005
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38261766
91Type I diabetes mellitus_Homo sapiens_hsa049400.37052836
92Circadian rhythm_Homo sapiens_hsa047100.36636594
93Alcoholism_Homo sapiens_hsa050340.36161643
94Histidine metabolism_Homo sapiens_hsa003400.36025057
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34931772
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33892147
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33577672
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32775355
99Prion diseases_Homo sapiens_hsa050200.32433954
100ABC transporters_Homo sapiens_hsa020100.32397494
101Huntingtons disease_Homo sapiens_hsa050160.31354868
102Rheumatoid arthritis_Homo sapiens_hsa053230.30990695
103Non-small cell lung cancer_Homo sapiens_hsa052230.30763161
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29019230
105Nitrogen metabolism_Homo sapiens_hsa009100.28578444
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28288513
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27736350
108Endometrial cancer_Homo sapiens_hsa052130.27603088
109Steroid biosynthesis_Homo sapiens_hsa001000.26103025
110Basal cell carcinoma_Homo sapiens_hsa052170.25898308
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25708389
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25522819
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.24272047
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24267907
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24261391
116Chemokine signaling pathway_Homo sapiens_hsa040620.23744435
117Endocytosis_Homo sapiens_hsa041440.22475327
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22103149
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21834205
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20820160

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