NOS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.78553280
2angiotensin maturation (GO:0002003)8.55499383
3antibacterial humoral response (GO:0019731)7.48027664
4antimicrobial humoral response (GO:0019730)7.27012874
5regulation of cellular extravasation (GO:0002691)7.09874805
6glomerular filtration (GO:0003094)7.07062532
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.94469004
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.94469004
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.86236446
10antigen processing and presentation of endogenous antigen (GO:0019883)6.47336213
11renal filtration (GO:0097205)6.33237020
12complement activation, classical pathway (GO:0006958)6.32384257
13intestinal absorption (GO:0050892)6.22298906
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.08668259
15positive regulation by organism of defense response of other organism involved in symbiotic interact6.08668259
16modulation by symbiont of host immune response (GO:0052553)6.08668259
17positive regulation by symbiont of host defense response (GO:0052509)6.08668259
18modulation by symbiont of host defense response (GO:0052031)6.08668259
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.08668259
20cellular response to type I interferon (GO:0071357)5.88863103
21type I interferon signaling pathway (GO:0060337)5.88863103
22response to type I interferon (GO:0034340)5.86719766
23positive regulation of interferon-alpha production (GO:0032727)5.51875896
24regulation of respiratory burst (GO:0060263)5.43678384
25positive regulation of pseudopodium assembly (GO:0031274)5.35945109
26regulation of interferon-alpha production (GO:0032647)5.32202222
27complement activation (GO:0006956)4.94744945
28maintenance of gastrointestinal epithelium (GO:0030277)4.92979569
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.81425563
30NADH metabolic process (GO:0006734)4.79549389
31regulation of pseudopodium assembly (GO:0031272)4.78763924
32negative regulation of viral genome replication (GO:0045071)4.75947195
33response to interferon-alpha (GO:0035455)4.66963502
34urea cycle (GO:0000050)4.66156354
35oligosaccharide biosynthetic process (GO:0009312)4.56286049
36macrophage activation involved in immune response (GO:0002281)4.55937677
37interferon-gamma-mediated signaling pathway (GO:0060333)4.55530744
38regulation of systemic arterial blood pressure by hormone (GO:0001990)4.54406707
39regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.54406707
40endocrine process (GO:0050886)4.54406707
41regulation of bile acid biosynthetic process (GO:0070857)4.39772211
42regulation of interferon-beta biosynthetic process (GO:0045357)4.38454201
43regulation of RIG-I signaling pathway (GO:0039535)4.37717776
44urea metabolic process (GO:0019627)4.32410797
45cellular response to interferon-alpha (GO:0035457)4.31480047
46positive regulation of chemokine biosynthetic process (GO:0045080)4.31294127
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30588843
48response to peptidoglycan (GO:0032494)4.29724417
49positive regulation of toll-like receptor signaling pathway (GO:0034123)4.29672819
50positive regulation of type 2 immune response (GO:0002830)4.24705458
51natural killer cell mediated cytotoxicity (GO:0042267)4.23858566
52natural killer cell mediated immunity (GO:0002228)4.23858566
53regulation of systemic arterial blood pressure (GO:0003073)4.23267346
54immunoglobulin mediated immune response (GO:0016064)4.21293427
55response to host immune response (GO:0052572)4.17320146
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17320146
57midgut development (GO:0007494)4.16960439
58regulation of dendritic cell antigen processing and presentation (GO:0002604)4.08953387
59lipoprotein transport (GO:0042953)4.08266615
60* regulation of guanylate cyclase activity (GO:0031282)4.02791235
61positive regulation of heat generation (GO:0031652)4.02218950
62positive regulation of antigen processing and presentation (GO:0002579)4.00410192
63hormone catabolic process (GO:0042447)3.95623080
64adhesion of symbiont to host cell (GO:0044650)3.94822617
65virion attachment to host cell (GO:0019062)3.94822617
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.93364063
67positive regulation of Cdc42 GTPase activity (GO:0043089)3.92563951
68nitrogen cycle metabolic process (GO:0071941)3.92419776
69positive regulation of interferon-beta production (GO:0032728)3.90728372
70receptor guanylyl cyclase signaling pathway (GO:0007168)3.89927186
71neutrophil activation involved in immune response (GO:0002283)3.85833857
72regulation of type I interferon-mediated signaling pathway (GO:0060338)3.84473018
73T-helper 1 type immune response (GO:0042088)3.84386092
74diacylglycerol metabolic process (GO:0046339)3.83067393
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75084645
76regulation of fever generation (GO:0031620)3.74831631
77epithelial structure maintenance (GO:0010669)3.73655208
78response to host defenses (GO:0052200)3.73514500
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73514500
80response to host (GO:0075136)3.73514500
81positive regulation of cAMP-mediated signaling (GO:0043950)3.72464061
82O-glycan processing (GO:0016266)3.70116105
83positive regulation of glycoprotein biosynthetic process (GO:0010560)3.69949811
84phosphatidylserine acyl-chain remodeling (GO:0036150)3.69741086
85fructose metabolic process (GO:0006000)3.69015188
86regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.65667709
87GDP-mannose metabolic process (GO:0019673)3.65160583
88cellular response to virus (GO:0098586)3.64730934
89respiratory burst (GO:0045730)3.63994221
90protein activation cascade (GO:0072376)3.63898734
91phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.63120693
92epoxygenase P450 pathway (GO:0019373)3.62274863
93peptide hormone processing (GO:0016486)3.61705663
94ethanol oxidation (GO:0006069)3.61608294
95response to muramyl dipeptide (GO:0032495)3.61540357
96lymphocyte chemotaxis (GO:0048247)3.58799069
97renal system process involved in regulation of blood volume (GO:0001977)3.57846891
98low-density lipoprotein particle clearance (GO:0034383)3.56641772
99regulation of vitamin metabolic process (GO:0030656)3.55524365
100* cellular response to interferon-gamma (GO:0071346)3.53821832
101defense response to protozoan (GO:0042832)3.52819604
102eosinophil chemotaxis (GO:0048245)3.52463961
103peptide catabolic process (GO:0043171)3.52319783
104humoral immune response (GO:0006959)3.47102225
105fucosylation (GO:0036065)3.43736920
106regulation of antigen processing and presentation (GO:0002577)3.43585721
107defense response to virus (GO:0051607)3.43396191
108digestive system process (GO:0022600)3.43159435
109positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43107317
110regulation of chemokine biosynthetic process (GO:0045073)3.40750937
111calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.40413495
112positive regulation of T cell cytokine production (GO:0002726)3.39826677
113response to interferon-beta (GO:0035456)3.39249273
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39170262
115positive regulation of glycoprotein metabolic process (GO:1903020)3.38649582
116regulation of podosome assembly (GO:0071801)3.37536498
117glycolipid catabolic process (GO:0019377)3.37280271
118microglial cell activation (GO:0001774)3.37276204
119cellular response to interferon-beta (GO:0035458)3.36606211
120positive regulation of interleukin-12 production (GO:0032735)3.35747855
121low-density lipoprotein particle remodeling (GO:0034374)3.35373645
122glycosphingolipid catabolic process (GO:0046479)3.34001790
123vitamin A metabolic process (GO:0006776)3.33869117
124negative regulation of epidermal cell differentiation (GO:0045605)3.33391432
125positive regulation of gamma-delta T cell activation (GO:0046645)3.32668464
126auditory receptor cell differentiation (GO:0042491)3.32269521
127hydrogen peroxide biosynthetic process (GO:0050665)3.32268538
128bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31983596
129NIK/NF-kappaB signaling (GO:0038061)3.31144383
130fat-soluble vitamin biosynthetic process (GO:0042362)3.31052548
131regulation of T-helper 1 cell differentiation (GO:0045625)3.31021675
132uronic acid metabolic process (GO:0006063)3.30248158
133glucuronate metabolic process (GO:0019585)3.30248158
134adhesion of symbiont to host (GO:0044406)3.29098175
135* response to interferon-gamma (GO:0034341)3.27282404
136cellular glucuronidation (GO:0052695)3.23804498
137regulation of toll-like receptor signaling pathway (GO:0034121)3.18731449
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.18727564
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.18372571
140positive regulation of natural killer cell differentiation (GO:0032825)3.17950824
141macrophage activation (GO:0042116)3.17146302
142negative regulation of myeloid cell apoptotic process (GO:0033033)3.14638439
143cGMP-mediated signaling (GO:0019934)3.13952953
144granulocyte activation (GO:0036230)3.13781882
145transcytosis (GO:0045056)3.13323926
146eosinophil migration (GO:0072677)3.11362364
147myeloid dendritic cell differentiation (GO:0043011)3.11206845
148phosphatidylinositol acyl-chain remodeling (GO:0036149)3.10259817
149B cell mediated immunity (GO:0019724)3.07724415
150response to protozoan (GO:0001562)3.07267641
151positive regulation of interleukin-17 production (GO:0032740)3.06786733
152positive regulation of response to biotic stimulus (GO:0002833)3.04128158
153intracellular pH reduction (GO:0051452)3.03131180
154cellular response to exogenous dsRNA (GO:0071360)3.02054054
155execution phase of apoptosis (GO:0097194)2.99991604
156I-kappaB phosphorylation (GO:0007252)2.99645013
157sexual reproduction (GO:0019953)2.99636691
158regulation of heat generation (GO:0031650)2.99143624
159digestion (GO:0007586)2.98342614
160very-low-density lipoprotein particle assembly (GO:0034379)2.97518099
161negative regulation of viral process (GO:0048525)2.95177269
162T cell migration (GO:0072678)2.92730801
163retina homeostasis (GO:0001895)2.91872196
164myeloid cell activation involved in immune response (GO:0002275)2.90994961
165reactive oxygen species biosynthetic process (GO:1903409)2.89174179
166positive regulation of cellular amide metabolic process (GO:0034250)2.88785098
167regulation of cholesterol storage (GO:0010885)2.88777067
168regulation of mononuclear cell migration (GO:0071675)2.88702549
169regulation of interleukin-12 biosynthetic process (GO:0045075)2.88515139
170nucleoside diphosphate biosynthetic process (GO:0009133)2.86735928
171drug metabolic process (GO:0017144)2.86594995
172labyrinthine layer development (GO:0060711)2.86236976
173regulation of interferon-beta production (GO:0032648)2.86210208
174regulation of interferon-gamma biosynthetic process (GO:0045072)2.85003480
175neutrophil activation (GO:0042119)2.84649627
176leukocyte mediated cytotoxicity (GO:0001909)2.84115416
177glomerulus development (GO:0032835)2.83662118
178negative regulation of epidermis development (GO:0045683)2.81766773
179glutamine family amino acid biosynthetic process (GO:0009084)2.79827818
180antigen processing and presentation via MHC class Ib (GO:0002475)2.79290646
181response to manganese ion (GO:0010042)2.78352652
182ethanol metabolic process (GO:0006067)2.77884226
183vitamin transmembrane transport (GO:0035461)2.75446687
184regulation of interleukin-12 production (GO:0032655)2.75052696
185desmosome organization (GO:0002934)2.71939267
186bile acid and bile salt transport (GO:0015721)2.68157234
187regulation of cholesterol homeostasis (GO:2000188)2.68046692
188citrulline metabolic process (GO:0000052)2.66029281
189thrombin receptor signaling pathway (GO:0070493)2.65595152
190chronic inflammatory response (GO:0002544)2.65118345
191glucocorticoid biosynthetic process (GO:0006704)2.64956186
192negative regulation of myotube differentiation (GO:0010832)2.64297065
193regulation of necrotic cell death (GO:0010939)2.62935201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.54879360
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.99355629
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.80629118
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.34572775
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.16128905
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36860960
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.36831814
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25479499
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00102507
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.94941149
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.88523606
12GATA1_22025678_ChIP-Seq_K562_Human2.86004278
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64234849
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.54122858
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48206339
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39946310
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32354070
18* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31236865
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26623551
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.25554766
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24790348
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16544198
23* GATA6_25053715_ChIP-Seq_YYC3_Human2.15472445
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13080057
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08233982
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95538506
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95112054
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94211272
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78149165
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74678562
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74228491
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.73141221
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66989930
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60244802
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.59577417
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59413100
37CLOCK_20551151_ChIP-Seq_293T_Human1.55674604
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.53939319
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51214761
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.51010806
41EGR1_19032775_ChIP-ChIP_M12_Human1.44693369
42SOX2_20726797_ChIP-Seq_SW620_Human1.43092022
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.42922362
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40343707
45VDR_24787735_ChIP-Seq_THP-1_Human1.38822665
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37080923
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36182829
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34946480
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34424524
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33195155
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.32990242
52VDR_24763502_ChIP-Seq_THP-1_Human1.31943038
53PU_27001747_Chip-Seq_BMDM_Mouse1.31489385
54DROSHA_22980978_ChIP-Seq_HELA_Human1.31173346
55MAF_26560356_Chip-Seq_TH1_Human1.30144476
56SPI1_23127762_ChIP-Seq_K562_Human1.29074353
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29039496
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27050567
59* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24235435
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.23834026
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20903727
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.20823331
63* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20365418
64KLF5_25053715_ChIP-Seq_YYC3_Human1.19951277
65SPI1_23547873_ChIP-Seq_NB4_Human1.19421874
66MYB_26560356_Chip-Seq_TH2_Human1.18690456
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.16614462
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.16332171
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13409431
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12739336
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.12581451
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12014050
73RUNX_20019798_ChIP-Seq_JUKART_Human1.10524710
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10097582
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07920938
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07491201
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05921827
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05710407
79RXR_22108803_ChIP-Seq_LS180_Human1.04637323
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03911324
81CTCF_27219007_Chip-Seq_Bcells_Human1.03091065
82JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02914424
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02682752
84* FOXA1_25552417_ChIP-Seq_VCAP_Human1.02453602
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.00839166
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99959835
87OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98764320
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98629895
89P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97071322
90SA1_27219007_Chip-Seq_Bcells_Human0.96496219
91ZNF263_19887448_ChIP-Seq_K562_Human0.96471965
92* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96127520
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95731728
94GATA1_19941826_ChIP-Seq_K562_Human0.95296865
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95108016
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93715052
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93714654
98VDR_21846776_ChIP-Seq_THP-1_Human0.93665559
99MYB_26560356_Chip-Seq_TH1_Human0.93426258
100AR_21909140_ChIP-Seq_LNCAP_Human0.92197494
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.92063183
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91231278
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90568335
104FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90504224
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.90197221
106* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90178354
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90157921
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90135537
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89697228
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89614853
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88197897
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88197897
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87893564
114* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87880026
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86864734
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86714954
117MYC_27129775_Chip-Seq_CORNEA_Mouse0.86642034
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86235361
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.85839269
120GATA2_19941826_ChIP-Seq_K562_Human0.85021123
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84058126
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83727743
123GATA3_26560356_Chip-Seq_TH2_Human0.82886853
124TCF7_22412390_ChIP-Seq_EML_Mouse0.82094794
125HNF4A_19822575_ChIP-Seq_HepG2_Human0.81892193
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.81864619
127* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81285123
128GATA3_27048872_Chip-Seq_THYMUS_Human0.81106002
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.80954433
130CDX2_22108803_ChIP-Seq_LS180_Human0.80868242
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80842676
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80347571
133* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79845780
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79673222
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79299292
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79299292
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79299292
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78956662
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78670886
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78646633
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78567498
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78443106
143* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78164773
144UTX_26944678_Chip-Seq_JUKART_Human0.77957917
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77902154
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77902154
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77659161
148RACK7_27058665_Chip-Seq_MCF-7_Human0.76901481
149* LXR_22292898_ChIP-Seq_THP-1_Human0.76554737
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76287299
151KDM2B_26808549_Chip-Seq_DND41_Human0.75018327
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74907707
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74844907
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74810904
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74356124
156CJUN_26792858_Chip-Seq_BT549_Human0.74184421
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73921887
158GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73465227
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73388387
160ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72942536
161CEBPB_22108803_ChIP-Seq_LS180_Human0.72892684
162IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72620008
163* GATA4_25053715_ChIP-Seq_YYC3_Human0.72303183
164SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72220542
165GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72197999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.96600279
2MP0009379_abnormal_foot_pigmentation5.24783412
3MP0003303_peritoneal_inflammation5.01977445
4MP0009785_altered_susceptibility_to4.18136492
5MP0001835_abnormal_antigen_presentation3.96011562
6MP0001666_abnormal_nutrient_absorption3.89594710
7MP0004510_myositis3.78648788
8MP0006082_CNS_inflammation3.55355956
9MP0002139_abnormal_hepatobiliary_system3.53293952
10MP0003724_increased_susceptibility_to3.49430316
11MP0004264_abnormal_extraembryonic_tissu3.40234949
12MP0005085_abnormal_gallbladder_physiolo3.39144495
13MP0003436_decreased_susceptibility_to3.22194125
14MP0000685_abnormal_immune_system2.96117106
15MP0002148_abnormal_hypersensitivity_rea2.91887026
16* MP0005025_abnormal_response_to2.90740918
17* MP0001790_abnormal_immune_system2.88245434
18* MP0005387_immune_system_phenotype2.88245434
19MP0004019_abnormal_vitamin_homeostasis2.84072595
20MP0002254_reproductive_system_inflammat2.82799657
21* MP0005000_abnormal_immune_tolerance2.71231230
22* MP0002419_abnormal_innate_immunity2.63628235
23MP0005058_abnormal_lysosome_morphology2.59633657
24MP0003866_abnormal_defecation2.54896224
25MP0000566_synostosis2.35316007
26MP0004147_increased_porphyrin_level2.35188887
27* MP0002452_abnormal_antigen_presenting2.24931719
28MP0005365_abnormal_bile_salt2.20077203
29* MP0002723_abnormal_immune_serum2.19207021
30* MP0001800_abnormal_humoral_immune2.17483127
31MP0005409_darkened_coat_color2.15235933
32MP0000477_abnormal_intestine_morphology2.14572704
33* MP0004947_skin_inflammation2.12333987
34* MP0001533_abnormal_skeleton_physiology2.09918047
35MP0000490_abnormal_crypts_of2.01857154
36MP0003172_abnormal_lysosome_physiology2.01027733
37MP0005310_abnormal_salivary_gland1.98379734
38MP0000678_abnormal_parathyroid_gland1.96606747
39MP0010234_abnormal_vibrissa_follicle1.93811073
40MP0009278_abnormal_bone_marrow1.90010034
41* MP0001819_abnormal_immune_cell1.88015294
42MP0003300_gastrointestinal_ulcer1.86463122
43MP0002420_abnormal_adaptive_immunity1.82567257
44* MP0001845_abnormal_inflammatory_respons1.81313784
45MP0002098_abnormal_vibrissa_morphology1.80789491
46* MP0010155_abnormal_intestine_physiology1.79956665
47MP0010352_gastrointestinal_tract_polyps1.77617651
48* MP0001664_abnormal_digestion1.73477976
49* MP0005671_abnormal_response_to1.73354905
50* MP0003448_altered_tumor_morphology1.73151831
51MP0001853_heart_inflammation1.72528646
52MP0009764_decreased_sensitivity_to1.72495334
53MP0009840_abnormal_foam_cell1.72317142
54MP0005381_digestive/alimentary_phenotyp1.68630339
55MP0000537_abnormal_urethra_morphology1.65827461
56* MP0008469_abnormal_protein_level1.64394447
57MP0000465_gastrointestinal_hemorrhage1.63798554
58* MP0003075_altered_response_to1.56661183
59MP0002405_respiratory_system_inflammati1.54282375
60* MP0000604_amyloidosis1.50521514
61* MP0005464_abnormal_platelet_physiology1.46544680
62* MP0000343_altered_response_to1.43673443
63* MP0004858_abnormal_nervous_system1.43520854
64MP0003191_abnormal_cellular_cholesterol1.42980067
65MP0005167_abnormal_blood-brain_barrier1.40337135
66MP0002796_impaired_skin_barrier1.40148566
67MP0001485_abnormal_pinna_reflex1.37352021
68MP0002138_abnormal_hepatobiliary_system1.35659395
69MP0003045_fibrosis1.35645768
70MP0003453_abnormal_keratinocyte_physiol1.34364235
71MP0004043_abnormal_pH_regulation1.31620298
72MP0005076_abnormal_cell_differentiation1.31427375
73MP0001545_abnormal_hematopoietic_system1.30942106
74MP0005397_hematopoietic_system_phenotyp1.30942106
75MP0002006_tumorigenesis1.30824055
76MP0009333_abnormal_splenocyte_physiolog1.28644760
77MP0000462_abnormal_digestive_system1.28304923
78* MP0000716_abnormal_immune_system1.26611942
79MP0003938_abnormal_ear_development1.25976307
80MP0000681_abnormal_thyroid_gland1.24751198
81* MP0009643_abnormal_urine_homeostasis1.24428317
82MP0005257_abnormal_intraocular_pressure1.23044702
83MP0003091_abnormal_cell_migration1.22039349
84MP0008260_abnormal_autophagy1.20046035
85MP0002166_altered_tumor_susceptibility1.18798998
86MP0001188_hyperpigmentation1.16694315
87MP0002277_abnormal_respiratory_mucosa1.14819725
88MP0003868_abnormal_feces_composition1.12813043
89MP0001765_abnormal_ion_homeostasis1.12583739
90* MP0002998_abnormal_bone_remodeling1.12184262
91MP0002332_abnormal_exercise_endurance1.10595692
92* MP0002398_abnormal_bone_marrow1.09627638
93MP0000858_altered_metastatic_potential1.08974488
94MP0003566_abnormal_cell_adhesion1.08919451
95MP0001851_eye_inflammation1.07602209
96* MP0005166_decreased_susceptibility_to1.06724395
97* MP0005164_abnormal_response_to1.05841646
98MP0010329_abnormal_lipoprotein_level1.05680750
99MP0005377_hearing/vestibular/ear_phenot1.04680013
100MP0003878_abnormal_ear_physiology1.04680013
101MP0003879_abnormal_hair_cell1.03879866
102MP0003705_abnormal_hypodermis_morpholog1.03057607
103MP0003252_abnormal_bile_duct1.01316689
104MP0003315_abnormal_perineum_morphology1.00702297
105* MP0002429_abnormal_blood_cell0.98364243
106* MP0005332_abnormal_amino_acid0.97444777
107MP0003690_abnormal_glial_cell0.96986268
108MP0009763_increased_sensitivity_to0.96523270
109MP0001873_stomach_inflammation0.93019489
110MP0005636_abnormal_mineral_homeostasis0.91965337
111MP0002933_joint_inflammation0.91663678
112* MP0002896_abnormal_bone_mineralization0.91503780
113MP0010030_abnormal_orbit_morphology0.89976893
114* MP0005390_skeleton_phenotype0.89229298
115* MP0005023_abnormal_wound_healing0.88790375
116MP0008004_abnormal_stomach_pH0.87794059
117MP0005083_abnormal_biliary_tract0.85446389
118MP0000569_abnormal_digit_pigmentation0.85250572
119MP0000689_abnormal_spleen_morphology0.84690717
120MP0002249_abnormal_larynx_morphology0.83755837
121MP0001663_abnormal_digestive_system0.83316690
122MP0005451_abnormal_body_composition0.83225051
123MP0000538_abnormal_urinary_bladder0.80760200
124MP0003183_abnormal_peptide_metabolism0.80360428
125MP0003221_abnormal_cardiomyocyte_apopto0.78647030
126MP0003828_pulmonary_edema0.78397849
127MP0002822_catalepsy0.78178982
128* MP0002722_abnormal_immune_system0.76693688
129MP0009115_abnormal_fat_cell0.73188628
130MP0003186_abnormal_redox_activity0.71313349
131MP0000377_abnormal_hair_follicle0.69701075
132MP0005448_abnormal_energy_balance0.68215089
133MP0005248_abnormal_Harderian_gland0.66608287
134MP0002876_abnormal_thyroid_physiology0.66491281
135MP0010678_abnormal_skin_adnexa0.66307314
136MP0000609_abnormal_liver_physiology0.65749469
137MP0001348_abnormal_lacrimal_gland0.65244808
138MP0002971_abnormal_brown_adipose0.65188438
139MP0003806_abnormal_nucleotide_metabolis0.64016726
140MP0003195_calcinosis0.63570656
141MP0005367_renal/urinary_system_phenotyp0.63550085
142MP0000516_abnormal_urinary_system0.63550085
143* MP0010307_abnormal_tumor_latency0.62682448
144MP0001958_emphysema0.62374258
145MP0000230_abnormal_systemic_arterial0.61518064
146MP0003656_abnormal_erythrocyte_physiolo0.61488745
147MP0005501_abnormal_skin_physiology0.61176682
148* MP0000249_abnormal_blood_vessel0.60837544
149* MP0002136_abnormal_kidney_physiology0.59272178
150MP0001216_abnormal_epidermal_layer0.56991991
151MP0003283_abnormal_digestive_organ0.56975639
152MP0005165_increased_susceptibility_to0.55945990
153MP0005666_abnormal_adipose_tissue0.55706101
154* MP0003795_abnormal_bone_structure0.55632779
155* MP0002118_abnormal_lipid_homeostasis0.55593313
156MP0008438_abnormal_cutaneous_collagen0.55075255
157* MP0005584_abnormal_enzyme/coenzyme_acti0.54757024
158MP0001849_ear_inflammation0.54073904
159MP0003693_abnormal_embryo_hatching0.54007446
160MP0003646_muscle_fatigue0.53619287
161MP0001346_abnormal_lacrimal_gland0.53576628
162MP0000026_abnormal_inner_ear0.53381102
163MP0003718_maternal_effect0.51204446
164* MP0001756_abnormal_urination0.49869133
165* MP0005319_abnormal_enzyme/_coenzyme0.49268940

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)6.88710121
2Eczematoid dermatitis (HP:0000976)6.05809094
3Chronic otitis media (HP:0000389)5.80659113
4Recurrent abscess formation (HP:0002722)5.59913754
5Recurrent bacterial skin infections (HP:0005406)5.27072193
6Abnormality of macrophages (HP:0004311)4.97245104
7Recurrent gram-negative bacterial infections (HP:0005420)4.74243934
8Ileus (HP:0002595)4.55278109
9Autoimmune thrombocytopenia (HP:0001973)4.53957892
10Nasal polyposis (HP:0100582)4.52552786
11Chronic diarrhea (HP:0002028)4.52551583
12Elevated erythrocyte sedimentation rate (HP:0003565)4.47288945
13Mediastinal lymphadenopathy (HP:0100721)4.41383191
14Increased cerebral lipofuscin (HP:0011813)4.35186504
15Glomerulonephritis (HP:0000099)4.33217337
16Abnormality of the nasal mucosa (HP:0000433)4.16419949
17Orchitis (HP:0100796)4.13297692
18Stomatitis (HP:0010280)4.11376593
19Tetraparesis (HP:0002273)4.06452103
20Decreased circulating renin level (HP:0003351)3.97425544
21Myositis (HP:0100614)3.94134290
22Interstitial pulmonary disease (HP:0006530)3.83516511
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81664460
24Recurrent skin infections (HP:0001581)3.74757762
25Hyperactive renin-angiotensin system (HP:0000841)3.71790515
26Alkalosis (HP:0001948)3.71241829
27Gingivitis (HP:0000230)3.70983651
28Abnormality of complement system (HP:0005339)3.70864436
29Retrobulbar optic neuritis (HP:0100654)3.64854739
30Optic neuritis (HP:0100653)3.64854739
31Recurrent fungal infections (HP:0002841)3.63496841
32Complement deficiency (HP:0004431)3.60023486
33Increased IgM level (HP:0003496)3.59622974
34Villous atrophy (HP:0011473)3.48203195
35Abnormality of small intestinal villus morphology (HP:0011472)3.48203195
36Proximal tubulopathy (HP:0000114)3.47300008
37Widely patent fontanelles and sutures (HP:0004492)3.45367765
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.41208725
39Pustule (HP:0200039)3.41158225
40Chronic mucocutaneous candidiasis (HP:0002728)3.36630889
41Recurrent cutaneous fungal infections (HP:0011370)3.36630889
42Abnormality of the vitamin B12 metabolism (HP:0004341)3.34123016
43Vasculitis (HP:0002633)3.32260049
44Fat malabsorption (HP:0002630)3.31540498
45Metabolic alkalosis (HP:0200114)3.30700859
46Right ventricular cardiomyopathy (HP:0011663)3.30116803
47Congenital sensorineural hearing impairment (HP:0008527)3.23848561
48Premature loss of primary teeth (HP:0006323)3.23644864
49Hypobetalipoproteinemia (HP:0003563)3.22955663
50Chronic sinusitis (HP:0011109)3.21971867
51Recurrent viral infections (HP:0004429)3.21868103
52Abnormality of renin-angiotensin system (HP:0000847)3.19214051
53Prostate neoplasm (HP:0100787)3.18700247
54Basal ganglia calcification (HP:0002135)3.13243030
55Acanthocytosis (HP:0001927)3.09124524
56Systemic lupus erythematosus (HP:0002725)3.07653417
57Abnormality of vitamin B metabolism (HP:0004340)3.03584862
58Keratoconjunctivitis (HP:0001096)2.97387614
59Hemorrhage of the eye (HP:0011885)2.96774303
60Loss of speech (HP:0002371)2.95589896
61Periodontitis (HP:0000704)2.92824299
62Vacuolated lymphocytes (HP:0001922)2.92801550
63Hypergammaglobulinemia (HP:0010702)2.92780222
64Flat acetabular roof (HP:0003180)2.90639949
65Recurrent bronchitis (HP:0002837)2.86433343
66Thick nail (HP:0001805)2.86263920
67Hydroxyprolinuria (HP:0003080)2.84188988
68Abnormality of proline metabolism (HP:0010907)2.84188988
69Abdominal distention (HP:0003270)2.80028133
70Hematochezia (HP:0002573)2.78380283
71Pigmentary retinal degeneration (HP:0001146)2.78094008
72Chronic obstructive pulmonary disease (HP:0006510)2.77461609
73Obstructive lung disease (HP:0006536)2.77461609
74Porencephaly (HP:0002132)2.72626891
75Abnormal tarsal ossification (HP:0008369)2.71137675
76Nausea (HP:0002018)2.70271129
77Axonal loss (HP:0003447)2.67566530
78Wide cranial sutures (HP:0010537)2.67274202
79Increased IgE level (HP:0003212)2.66066457
80Abnormality of liposaccharide metabolism (HP:0010968)2.63862171
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.63862171
82Abnormality of glycolipid metabolism (HP:0010969)2.63862171
83Pulmonary infiltrates (HP:0002113)2.60924109
84Nephrolithiasis (HP:0000787)2.60735988
85Urticaria (HP:0001025)2.56823226
86Neoplasm of head and neck (HP:0012288)2.51741585
87Esophageal neoplasm (HP:0100751)2.51741585
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50826573
89Abnormality of pyrimidine metabolism (HP:0004353)2.49535124
90Vertebral compression fractures (HP:0002953)2.49534788
91Emphysema (HP:0002097)2.48763740
92Abnormality of urine glucose concentration (HP:0011016)2.47766109
93Glycosuria (HP:0003076)2.47766109
94Disinhibition (HP:0000734)2.46616819
95Hyperuricemia (HP:0002149)2.45590535
96Increased purine levels (HP:0004368)2.45590535
97Myocardial infarction (HP:0001658)2.42794169
98Abnormality of vitamin metabolism (HP:0100508)2.42604443
99Pili torti (HP:0003777)2.38398815
100Hyperglycinuria (HP:0003108)2.37803307
101Osteomyelitis (HP:0002754)2.37319220
102Cellulitis (HP:0100658)2.37279973
103Delayed epiphyseal ossification (HP:0002663)2.35709223
104Hyperparathyroidism (HP:0000843)2.35624546
105Hyperammonemia (HP:0001987)2.35608575
106Abnormality of the distal phalanx of the thumb (HP:0009617)2.32776067
107Thin bony cortex (HP:0002753)2.31918909
108Increased serum ferritin (HP:0003281)2.29940855
109Confusion (HP:0001289)2.29282557
110Hyperphosphatemia (HP:0002905)2.28441996
111Cerebral palsy (HP:0100021)2.26612477
112Autoimmune hemolytic anemia (HP:0001890)2.25165868
113Dysostosis multiplex (HP:0000943)2.24628958
114Frequent falls (HP:0002359)2.22761811
115Posterior subcapsular cataract (HP:0007787)2.21321581
116Hypophosphatemia (HP:0002148)2.20750998
117Keratoconjunctivitis sicca (HP:0001097)2.20538053
118Bone pain (HP:0002653)2.20498168
119Arterial thrombosis (HP:0004420)2.20141145
120Focal segmental glomerulosclerosis (HP:0000097)2.19722317
121Abnormality of the phalanges of the hallux (HP:0010057)2.19359628
122Urinary glycosaminoglycan excretion (HP:0003541)2.19335621
123Mucopolysacchariduria (HP:0008155)2.19335621
124Esophageal varix (HP:0002040)2.19302029
125Gastrointestinal infarctions (HP:0005244)2.16493552
126Hemoptysis (HP:0002105)2.16078083
127Abnormality of serine family amino acid metabolism (HP:0010894)2.15950190
128Abnormality of glycine metabolism (HP:0010895)2.15950190
129Hepatosplenomegaly (HP:0001433)2.14506222
130Hypotension (HP:0002615)2.13481476
131Abnormality of the 1st metacarpal (HP:0010009)2.13375429
132Abnormality of nucleobase metabolism (HP:0010932)2.11532596
133Peritonitis (HP:0002586)2.10864717
134Partial duplication of thumb phalanx (HP:0009944)2.07483108
135Cupped ribs (HP:0000887)2.07212052
136Skin ulcer (HP:0200042)2.07002829
137Leukocytosis (HP:0001974)2.04116139
138Pancreatitis (HP:0001733)2.04060098
139Abnormality of polysaccharide metabolism (HP:0011012)2.03155174
140Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03155174
141Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03155174
142Protuberant abdomen (HP:0001538)2.02498355
143Abnormal hair laboratory examination (HP:0003328)2.01041866
144Gingival bleeding (HP:0000225)2.00535310
145Anorexia (HP:0002039)2.00315358
146Abnormal biliary tract morphology (HP:0012440)1.99185997
147Inflammation of the large intestine (HP:0002037)1.97957241
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97824297
149Ventricular fibrillation (HP:0001663)1.97541334
150Abnormality of the pericardium (HP:0001697)1.97317938
151Abnormality of magnesium homeostasis (HP:0004921)1.96981097
152Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94540335
153Abnormality of purine metabolism (HP:0004352)1.94114771
154Recurrent lower respiratory tract infections (HP:0002783)1.93213738
155Osteolytic defects of the hand bones (HP:0009699)1.91828801
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.91828801
157Facial shape deformation (HP:0011334)1.91408207
158Potter facies (HP:0002009)1.91408207
159Abnormality of iron homeostasis (HP:0011031)1.91175203
160Biliary tract neoplasm (HP:0100574)1.90976356
161Nephritis (HP:0000123)1.90630145
162Gastrointestinal inflammation (HP:0004386)1.90062574
163Recurrent pneumonia (HP:0006532)1.89369774
164Plantar hyperkeratosis (HP:0007556)1.89328493
165Spastic tetraparesis (HP:0001285)1.89302496
166Broad metatarsal (HP:0001783)1.88641451
167Micronodular cirrhosis (HP:0001413)1.88584743
168Xanthomatosis (HP:0000991)1.88290495
169Intrahepatic cholestasis (HP:0001406)1.87598587
170Dicarboxylic aciduria (HP:0003215)1.85813443
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85813443
172Growth hormone excess (HP:0000845)1.84661324
173Rectal prolapse (HP:0002035)1.83933225
174Lower limb hyperreflexia (HP:0002395)1.83671122
175Reticulocytosis (HP:0001923)1.83049968
176Progressive visual loss (HP:0000529)1.82465980
177Colitis (HP:0002583)1.82366731
178Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80375233
179Curly hair (HP:0002212)1.75538278
180Abnormality of carpal bone ossification (HP:0006257)1.75461521
181Goiter (HP:0000853)1.74372659
182Hypokalemia (HP:0002900)1.74137920
183Flattened epiphyses (HP:0003071)1.72606727
184Gastrointestinal dysmotility (HP:0002579)1.72135158
185Gastrointestinal stroma tumor (HP:0100723)1.71714603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.50701526
2ACVR1B4.49922732
3TYK24.26015938
4MAP3K144.25621328
5PBK3.89294907
6IKBKE3.89199585
7IRAK33.22480992
8EPHB22.99994638
9ERN12.95941387
10BLK2.80029118
11RIPK42.78715137
12STK392.78334557
13EPHB12.65874935
14EPHA42.65516797
15JAK32.55506000
16JAK12.52164337
17FGFR42.48051645
18KIT2.46198586
19IRAK42.26959836
20MET2.16255845
21OXSR12.13393057
22MAP3K132.00102302
23EPHA31.94936012
24IKBKB1.92510361
25MST41.89185117
26STK241.78141530
27CSK1.67972656
28FGFR31.62296452
29FGR1.56604743
30MATK1.56125682
31PIM21.49747733
32CHUK1.45452597
33LATS11.44837057
34CDC42BPA1.43912312
35BMX1.43484598
36PRPF4B1.30585275
37PTK61.27296453
38MST1R1.27184172
39JAK21.16496608
40NME11.11773545
41MAP4K11.10510256
42RIPK11.06559605
43RPS6KA41.05286746
44MAP3K121.02677670
45PDGFRA1.02157248
46HCK1.00766798
47ARAF0.99206239
48TAOK30.95161499
49MAP3K100.94308554
50SYK0.91799332
51TESK20.90018758
52MAP3K50.89246754
53CDK190.89157747
54FGFR20.88988729
55ABL20.87294678
56LCK0.87169512
57DDR20.85453179
58ERBB20.85292344
59LMTK20.84423778
60STK100.83631156
61ZAP700.83185177
62LYN0.81238733
63DMPK0.80120991
64DYRK1B0.79390569
65FES0.79350752
66MAP3K10.77374597
67MAP3K90.77180947
68KSR20.76803752
69MAP3K20.76152217
70EGFR0.75707429
71PRKG20.75519121
72MYLK0.73016516
73NME20.72373153
74TXK0.70268824
75TYRO30.69307587
76ALK0.68522331
77IRAK10.67349172
78PDK20.67171925
79MAP3K70.67105287
80MARK30.64349725
81TIE10.64009701
82GRK60.59694148
83STK38L0.57083567
84TTN0.56919257
85ABL10.55344024
86MAP3K110.53351645
87FRK0.53202165
88LRRK20.52433951
89CAMK2D0.52047973
90TNIK0.51236146
91CSF1R0.51135342
92TESK10.50005898
93TRIB30.48038443
94TGFBR20.47997855
95MOS0.47227725
96AKT30.45123451
97EIF2AK20.45022127
98STK40.44809930
99FYN0.44777789
100SMG10.44415786
101NLK0.44018812
102PDGFRB0.42823094
103PRKCD0.42427036
104DAPK30.41127448
105YES10.40959311
106PRKACG0.40868296
107PIM10.40183542
108PRKCA0.37569490
109PRKAA20.37482389
110EPHA20.37466012
111SIK30.36739602
112CDK60.36633841
113LATS20.35710696
114ERBB40.35586494
115BTK0.34866334
116MAP2K20.34488784
117FER0.33436020
118MAP2K60.32246593
119PTK20.32164398
120MAP3K30.31738157
121MAPKAPK20.31056960
122WNK40.30859227
123PRKCZ0.30775754
124DAPK20.30070640
125* SRC0.29926554
126PDPK10.29336342
127PKN20.28483616
128TAOK10.27571436
129KDR0.27170243
130CASK0.25852287
131PAK40.25713674
132STK30.25603343
133MAPK110.24900339
134IGF1R0.24224610
135PRKCQ0.24217899
136CAMK2G0.24170635
137PIK3CA0.23783596
138MAPK40.23177892
139RET0.22739459
140MELK0.22738754
141BMPR20.21555449
142NEK90.21347236
143PTK2B0.20647183
144PLK20.19900968
145RPS6KA10.19539329
146SIK10.19333511
147INSR0.18905122
148PDK10.18307584
149MAPK70.17905677

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.44038163
2Fat digestion and absorption_Homo sapiens_hsa049754.06002508
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.12765107
4* Leishmaniasis_Homo sapiens_hsa051403.00195425
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.88190196
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.87274648
7Vitamin digestion and absorption_Homo sapiens_hsa049772.64905783
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53410358
9Staphylococcus aureus infection_Homo sapiens_hsa051502.53106425
10Influenza A_Homo sapiens_hsa051642.47027605
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.43918936
12TNF signaling pathway_Homo sapiens_hsa046682.37274645
13Osteoclast differentiation_Homo sapiens_hsa043802.30979877
14Protein digestion and absorption_Homo sapiens_hsa049742.27327180
15Measles_Homo sapiens_hsa051622.22423497
16Allograft rejection_Homo sapiens_hsa053302.21966478
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20415104
18Malaria_Homo sapiens_hsa051442.14129873
19Legionellosis_Homo sapiens_hsa051342.08447275
20* Pertussis_Homo sapiens_hsa051332.04042639
21African trypanosomiasis_Homo sapiens_hsa051432.03103506
22Linoleic acid metabolism_Homo sapiens_hsa005912.01669803
23Sulfur metabolism_Homo sapiens_hsa009202.00075489
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94321982
25* Arginine biosynthesis_Homo sapiens_hsa002201.94085633
26* Tuberculosis_Homo sapiens_hsa051521.89104849
27Graft-versus-host disease_Homo sapiens_hsa053321.81651012
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81646927
29* Toxoplasmosis_Homo sapiens_hsa051451.76601337
30Asthma_Homo sapiens_hsa053101.76409869
31Herpes simplex infection_Homo sapiens_hsa051681.75643155
32Hepatitis C_Homo sapiens_hsa051601.74493668
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.69094656
34Antigen processing and presentation_Homo sapiens_hsa046121.68218706
35Rheumatoid arthritis_Homo sapiens_hsa053231.64996397
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62544063
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61745012
38Starch and sucrose metabolism_Homo sapiens_hsa005001.56582971
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49528649
40Retinol metabolism_Homo sapiens_hsa008301.43680425
41Lysosome_Homo sapiens_hsa041421.43443325
42Arachidonic acid metabolism_Homo sapiens_hsa005901.41287929
43B cell receptor signaling pathway_Homo sapiens_hsa046621.36665677
44Apoptosis_Homo sapiens_hsa042101.33152619
45* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31884583
46Fatty acid degradation_Homo sapiens_hsa000711.27715817
47Chemokine signaling pathway_Homo sapiens_hsa040621.26864714
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.24557187
49* Salmonella infection_Homo sapiens_hsa051321.24099949
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.24042053
51PPAR signaling pathway_Homo sapiens_hsa033201.23461490
52Shigellosis_Homo sapiens_hsa051311.22267888
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22094832
54Chemical carcinogenesis_Homo sapiens_hsa052041.20723887
55Glycerolipid metabolism_Homo sapiens_hsa005611.20357598
56Phagosome_Homo sapiens_hsa041451.19232642
57Hepatitis B_Homo sapiens_hsa051611.17795150
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17705333
59Caffeine metabolism_Homo sapiens_hsa002321.17165035
60Ether lipid metabolism_Homo sapiens_hsa005651.16922459
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15523086
62Mineral absorption_Homo sapiens_hsa049781.14507412
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12926649
64Viral myocarditis_Homo sapiens_hsa054161.12110607
65Bile secretion_Homo sapiens_hsa049761.10103163
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09325649
67Type II diabetes mellitus_Homo sapiens_hsa049301.07312174
68Primary immunodeficiency_Homo sapiens_hsa053401.06970391
69Type I diabetes mellitus_Homo sapiens_hsa049401.06611909
70Pancreatic secretion_Homo sapiens_hsa049721.06526272
71Glycosaminoglycan degradation_Homo sapiens_hsa005311.06426222
72Adipocytokine signaling pathway_Homo sapiens_hsa049201.05856405
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05131524
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.99868836
75Prolactin signaling pathway_Homo sapiens_hsa049170.98141650
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97722736
77* Arginine and proline metabolism_Homo sapiens_hsa003300.97155532
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95311924
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93584682
80Sulfur relay system_Homo sapiens_hsa041220.92413769
81Thyroid hormone synthesis_Homo sapiens_hsa049180.92005531
82* Amoebiasis_Homo sapiens_hsa051460.90455771
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.90247640
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.89125072
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86781822
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86477845
87Hematopoietic cell lineage_Homo sapiens_hsa046400.84251933
88Glutathione metabolism_Homo sapiens_hsa004800.81262258
89Autoimmune thyroid disease_Homo sapiens_hsa053200.80300949
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79223379
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75517476
92Tryptophan metabolism_Homo sapiens_hsa003800.75472159
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75256086
94* HIF-1 signaling pathway_Homo sapiens_hsa040660.72666890
95Acute myeloid leukemia_Homo sapiens_hsa052210.71147162
96VEGF signaling pathway_Homo sapiens_hsa043700.71046106
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70439452
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69291278
99Chronic myeloid leukemia_Homo sapiens_hsa052200.68586910
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68373583
101* Small cell lung cancer_Homo sapiens_hsa052220.65054392
102Pancreatic cancer_Homo sapiens_hsa052120.63156299
103Dorso-ventral axis formation_Homo sapiens_hsa043200.61806967
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.61734752
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60470581
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.58393218
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.53434899
108Insulin resistance_Homo sapiens_hsa049310.51650408
109T cell receptor signaling pathway_Homo sapiens_hsa046600.50533337
110Prion diseases_Homo sapiens_hsa050200.49859346
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49460286
112Galactose metabolism_Homo sapiens_hsa000520.48934937
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48894792
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46190533
115Other glycan degradation_Homo sapiens_hsa005110.43913728
116Epstein-Barr virus infection_Homo sapiens_hsa051690.43335807
117Hedgehog signaling pathway_Homo sapiens_hsa043400.43218517
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42426915
119Folate biosynthesis_Homo sapiens_hsa007900.41835782
120Tight junction_Homo sapiens_hsa045300.41451877
121Proteoglycans in cancer_Homo sapiens_hsa052050.39990808
122Viral carcinogenesis_Homo sapiens_hsa052030.38394003
123Renin secretion_Homo sapiens_hsa049240.38005468
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37529379
125Platelet activation_Homo sapiens_hsa046110.36186653
126Fatty acid metabolism_Homo sapiens_hsa012120.36042821
127Fructose and mannose metabolism_Homo sapiens_hsa000510.35829745
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35537232
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34967479
130Renal cell carcinoma_Homo sapiens_hsa052110.34872879
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34194988
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33433625
133Notch signaling pathway_Homo sapiens_hsa043300.32457509
134MicroRNAs in cancer_Homo sapiens_hsa052060.30229291
135Fatty acid biosynthesis_Homo sapiens_hsa000610.29424735
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28991785
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28558361
138Sphingolipid metabolism_Homo sapiens_hsa006000.28362329
139Renin-angiotensin system_Homo sapiens_hsa046140.26832113
140Focal adhesion_Homo sapiens_hsa045100.22455040
141ABC transporters_Homo sapiens_hsa020100.22020310
142Complement and coagulation cascades_Homo sapiens_hsa046100.21733529
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.20941542
144Phenylalanine metabolism_Homo sapiens_hsa003600.20494604
145Endocytosis_Homo sapiens_hsa041440.20477380
146Histidine metabolism_Homo sapiens_hsa003400.20326279
147HTLV-I infection_Homo sapiens_hsa051660.18003734
148Systemic lupus erythematosus_Homo sapiens_hsa053220.17506503
149Nitrogen metabolism_Homo sapiens_hsa009100.17389683
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17008600
151Vibrio cholerae infection_Homo sapiens_hsa051100.15745809
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.14729154
153GnRH signaling pathway_Homo sapiens_hsa049120.12393377
154Biosynthesis of amino acids_Homo sapiens_hsa012300.10545686
155* Peroxisome_Homo sapiens_hsa041460.08934199
156Carbon metabolism_Homo sapiens_hsa012000.08894807

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