NOS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.84575276
2endothelium development (GO:0003158)6.18476676
3vascular endothelial growth factor signaling pathway (GO:0038084)5.68937974
4cardiac myofibril assembly (GO:0055003)5.30808568
5plasma membrane fusion (GO:0045026)5.30715318
6heart trabecula formation (GO:0060347)5.25422125
7sarcomere organization (GO:0045214)5.12274960
8wound healing, spreading of epidermal cells (GO:0035313)5.11868437
9retina vasculature morphogenesis in camera-type eye (GO:0061299)5.09348183
10positive regulation of endothelial cell differentiation (GO:0045603)4.91761336
11cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.85986483
12bundle of His cell to Purkinje myocyte communication (GO:0086069)4.62299712
13positive regulation of vasculogenesis (GO:2001214)4.61899586
14angiogenesis involved in wound healing (GO:0060055)4.61108555
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.52976986
16myofibril assembly (GO:0030239)4.52658954
17plasma membrane repair (GO:0001778)4.50997005
18regulation of establishment or maintenance of cell polarity (GO:0032878)4.36578091
19endothelial cell proliferation (GO:0001935)4.31852478
20fatty acid transmembrane transport (GO:1902001)4.17069944
21lymphangiogenesis (GO:0001946)4.16252075
22endothelial cell morphogenesis (GO:0001886)4.16092684
23regulation of sarcomere organization (GO:0060297)4.15048271
24blood vessel maturation (GO:0001955)4.12463182
25ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.11690922
26negative regulation of potassium ion transmembrane transport (GO:1901380)4.11477857
27regulation of vasculogenesis (GO:2001212)4.06412566
28carnitine shuttle (GO:0006853)4.05470117
29regulation of endothelial cell differentiation (GO:0045601)4.03329466
30acrosome reaction (GO:0007340)4.01127336
31sprouting angiogenesis (GO:0002040)3.99365949
32morphogenesis of an endothelium (GO:0003159)3.92794158
33endothelial tube morphogenesis (GO:0061154)3.92794158
34vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.92541443
35regulation of actin filament-based movement (GO:1903115)3.89292870
36glomerular filtration (GO:0003094)3.89079459
37artery development (GO:0060840)3.86547489
38patterning of blood vessels (GO:0001569)3.85058419
39cardiac muscle tissue morphogenesis (GO:0055008)3.84145087
40tricarboxylic acid cycle (GO:0006099)3.81059063
41actin-myosin filament sliding (GO:0033275)3.75325818
42muscle filament sliding (GO:0030049)3.75325818
43hyaluronan catabolic process (GO:0030214)3.73640545
44basement membrane organization (GO:0071711)3.73462537
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.72498293
46cardiac muscle contraction (GO:0060048)3.70441437
47surfactant homeostasis (GO:0043129)3.66816482
48renal filtration (GO:0097205)3.66139049
49sperm motility (GO:0030317)3.64376565
50cardiac muscle cell development (GO:0055013)3.60838555
51venous blood vessel morphogenesis (GO:0048845)3.58935911
52regulation of sequestering of triglyceride (GO:0010889)3.57164871
53cell migration involved in sprouting angiogenesis (GO:0002042)3.53691288
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52827371
55fusion of sperm to egg plasma membrane (GO:0007342)3.51448505
56endothelial cell differentiation (GO:0045446)3.50636343
57embryonic heart tube development (GO:0035050)3.50318506
58ventricular cardiac muscle cell action potential (GO:0086005)3.47867464
59muscle tissue morphogenesis (GO:0060415)3.47040151
60cardiac cell development (GO:0055006)3.46681789
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.45274207
62response to pheromone (GO:0019236)3.45133516
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44866782
64positive regulation of urine volume (GO:0035810)3.43454792
65peptidyl-tyrosine autophosphorylation (GO:0038083)3.40884763
66actomyosin structure organization (GO:0031032)3.40614469
67regulation of cardioblast differentiation (GO:0051890)3.39136770
68trabecula formation (GO:0060343)3.36245699
69regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.36044152
70regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.34487005
71cardiac muscle hypertrophy (GO:0003300)3.33112437
72blood vessel endothelial cell migration (GO:0043534)3.32430719
73regulation of establishment of cell polarity (GO:2000114)3.30543217
74adult heart development (GO:0007512)3.29399282
75vasculogenesis (GO:0001570)3.28779450
76negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.26392545
77low-density lipoprotein particle clearance (GO:0034383)3.24107554
78striated muscle hypertrophy (GO:0014897)3.19444814
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.19181326
80ventricular trabecula myocardium morphogenesis (GO:0003222)3.18168746
81negative regulation of Rho protein signal transduction (GO:0035024)3.15903312
82negative regulation of blood vessel endothelial cell migration (GO:0043537)3.15513371
83cell communication involved in cardiac conduction (GO:0086065)3.15370664
84negative regulation of DNA biosynthetic process (GO:2000279)3.14073345
85regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.12029484
86cardiac muscle cell proliferation (GO:0060038)3.08672348
87actin-mediated cell contraction (GO:0070252)3.08372536
88chemical homeostasis within a tissue (GO:0048875)3.05414231
89regulation of synapse maturation (GO:0090128)3.05386919
90regulation of cardiac muscle cell contraction (GO:0086004)3.04526597
91carnitine transmembrane transport (GO:1902603)3.03550370
92cell communication by electrical coupling (GO:0010644)3.03190353
93negative regulation of endothelial cell migration (GO:0010596)3.01245326
94cellular ketone body metabolic process (GO:0046950)3.00753261
95positive regulation of receptor recycling (GO:0001921)2.99794468
96regulation of striated muscle contraction (GO:0006942)2.99197461
97anatomical structure maturation (GO:0071695)2.97819949
98establishment of protein localization to Golgi (GO:0072600)2.97219333
99transcytosis (GO:0045056)2.97022779
100nephron epithelium development (GO:0072009)2.96955108
101gap junction assembly (GO:0016264)2.95932823
102heart trabecula morphogenesis (GO:0061384)2.95721347
103* regulation of the force of heart contraction (GO:0002026)2.93349805
104regulation of relaxation of muscle (GO:1901077)2.93287620
105regulation of membrane repolarization (GO:0060306)2.92577441
106fatty acid beta-oxidation (GO:0006635)2.91735850
107regulation of skeletal muscle contraction (GO:0014819)2.91594636
108cardiac muscle cell action potential involved in contraction (GO:0086002)2.89127152
109peptidyl-threonine dephosphorylation (GO:0035970)2.88775329
110multicellular organism reproduction (GO:0032504)2.88227900
111cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88211549
112cardiac muscle cell action potential (GO:0086001)2.85367897
113protein kinase C signaling (GO:0070528)2.83801201
114protein targeting to Golgi (GO:0000042)2.82781929
115regulation of blood vessel endothelial cell migration (GO:0043535)2.82307107
116regulation of p38MAPK cascade (GO:1900744)2.82053223
117carnitine transport (GO:0015879)2.80991947
118amino-acid betaine transport (GO:0015838)2.80991947
119platelet dense granule organization (GO:0060155)2.80781998
120coronary vasculature morphogenesis (GO:0060977)2.80700666
121regulation of urine volume (GO:0035809)2.79662350
122positive regulation of endothelial cell proliferation (GO:0001938)2.79001619
123regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77638057
124negative regulation of endothelial cell apoptotic process (GO:2000352)2.77551975
125negative regulation of epithelial cell migration (GO:0010633)2.77524961
126muscle hypertrophy (GO:0014896)2.77510645
127positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.77046994
128regulation of fatty acid oxidation (GO:0046320)2.76372052
1292-oxoglutarate metabolic process (GO:0006103)2.74103458
130* angiogenesis (GO:0001525)2.73307362
131cardiac muscle adaptation (GO:0014887)2.72982163
132cardiac muscle hypertrophy in response to stress (GO:0014898)2.72982163
133muscle hypertrophy in response to stress (GO:0003299)2.72982163
134trabecula morphogenesis (GO:0061383)2.72804359
135biotin metabolic process (GO:0006768)2.70718273
136protein polyglutamylation (GO:0018095)2.69126596
137positive regulation of protein kinase C signaling (GO:0090037)2.68589519
138negative regulation of adherens junction organization (GO:1903392)2.63918503
139negative regulation of focal adhesion assembly (GO:0051895)2.63918503
140negative regulation of cell junction assembly (GO:1901889)2.63918503
141negative regulation of angiogenesis (GO:0016525)2.61687529
142regulation of endothelial cell migration (GO:0010594)2.59937174
143negative regulation of protein autophosphorylation (GO:0031953)2.59166831
144facial nerve structural organization (GO:0021612)2.58140013
145retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57846492
146glomerular visceral epithelial cell development (GO:0072015)2.56292656
147ketone body metabolic process (GO:1902224)2.56000161
148renal absorption (GO:0070293)2.54996183
149protein localization to Golgi apparatus (GO:0034067)2.54528195
150ganglion development (GO:0061548)2.53285559
151negative regulation of blood vessel morphogenesis (GO:2000181)2.53203872
152positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.52853057
153wound healing, spreading of cells (GO:0044319)2.52155946
154definitive hemopoiesis (GO:0060216)2.49360491
155cardiac muscle tissue development (GO:0048738)2.46294242
156negative regulation of actin filament bundle assembly (GO:0032232)2.44091780
157semaphorin-plexin signaling pathway (GO:0071526)2.43819379
158pharyngeal system development (GO:0060037)2.42760848
159atrial cardiac muscle cell action potential (GO:0086014)2.41273414
160heparin biosynthetic process (GO:0030210)2.39433676
161heparin metabolic process (GO:0030202)2.39433676
162alanine transport (GO:0032328)2.39293100
163negative regulation of vasculature development (GO:1901343)2.37253746
164cAMP biosynthetic process (GO:0006171)2.37061121
165NAD biosynthetic process (GO:0009435)2.36524402
166response to misfolded protein (GO:0051788)2.36513149
167organic cation transport (GO:0015695)2.32217552
168ear development (GO:0043583)2.31305090
169endothelial cell chemotaxis (GO:0035767)2.31071407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.51851099
2VDR_22108803_ChIP-Seq_LS180_Human3.26095426
3CLOCK_20551151_ChIP-Seq_293T_Human3.24447010
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.20192582
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.14956427
6GATA2_21666600_ChIP-Seq_HMVEC_Human2.84811911
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.75444237
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72091293
9ZNF263_19887448_ChIP-Seq_K562_Human2.55106554
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.54455589
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.54455589
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54272920
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24833912
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15892874
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12289480
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.10123130
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90086088
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89895526
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.89439117
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.86070823
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.85842293
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79778914
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.78294988
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75898788
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75835276
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75788913
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.71296668
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70365350
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69564664
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68370572
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66227606
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61565292
33AR_21572438_ChIP-Seq_LNCaP_Human1.60039606
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59684910
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58046323
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55765493
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53184630
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48680086
39* GATA1_19941826_ChIP-Seq_K562_Human1.46201296
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44938883
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44791957
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43199003
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43199003
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41687725
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40965862
46ERA_21632823_ChIP-Seq_H3396_Human1.36075232
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.35097380
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34399476
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.32944333
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.32805554
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31975946
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31766367
53MYC_19829295_ChIP-Seq_ESCs_Human1.29861145
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29119569
55ER_23166858_ChIP-Seq_MCF-7_Human1.28675271
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.27955427
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27837231
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.27621738
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27009441
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26593832
61KDM2B_26808549_Chip-Seq_K562_Human1.26291514
62RAC3_21632823_ChIP-Seq_H3396_Human1.25433602
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.24323629
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.24010391
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23916237
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.23609253
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23507343
68* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23085574
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22638131
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22382601
71CJUN_26792858_Chip-Seq_BT549_Human1.22318361
72TCF4_23295773_ChIP-Seq_U87_Human1.20965168
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20688371
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20541489
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20394508
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20168628
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19488031
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19488031
79TCF4_22108803_ChIP-Seq_LS180_Human1.19297367
80* DROSHA_22980978_ChIP-Seq_HELA_Human1.19096480
81* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18721048
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18332997
83GATA1_22025678_ChIP-Seq_K562_Human1.16847768
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16371213
85PHF8_20622854_ChIP-Seq_HELA_Human1.15058087
86E2F1_20622854_ChIP-Seq_HELA_Human1.15054162
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14966455
88TAF2_19829295_ChIP-Seq_ESCs_Human1.14652534
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14242473
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14119024
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13606431
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13585080
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12524936
94P300_19829295_ChIP-Seq_ESCs_Human1.11954151
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.11572218
96FOXH1_21741376_ChIP-Seq_ESCs_Human1.11520568
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11160354
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.11043087
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10816848
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10617382
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10589596
102GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10263701
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.09422561
104AHR_22903824_ChIP-Seq_MCF-7_Human1.08313968
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07506147
106STAT3_23295773_ChIP-Seq_U87_Human1.07416982
107GBX2_23144817_ChIP-Seq_PC3_Human1.06999431
108NANOG_20526341_ChIP-Seq_ESCs_Human1.06627825
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05335396
110OCT4_20526341_ChIP-Seq_ESCs_Human1.04908655
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04742463
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03438990
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03165743
114FOXH1_21741376_ChIP-Seq_EPCs_Human1.03030535
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02843964
116OCT1_27270436_Chip-Seq_PROSTATE_Human1.02312872
117OCT4_19829295_ChIP-Seq_ESCs_Human1.02103817
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01579070
119RUNX2_22187159_ChIP-Seq_PCA_Human1.01451119
120* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00587591
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00179450
122HOXB7_26014856_ChIP-Seq_BT474_Human0.99871892
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99793989
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98750864
125LXR_22292898_ChIP-Seq_THP-1_Human0.98478791
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98171058
127CBP_20019798_ChIP-Seq_JUKART_Human0.98171058
128SMAD4_21799915_ChIP-Seq_A2780_Human0.97898171
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97677954
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97274804
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97241920
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96821224
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96515907
134BCL6_27268052_Chip-Seq_Bcells_Human0.96360104
135P53_21459846_ChIP-Seq_SAOS-2_Human0.96322091
136WDR5_24793694_ChIP-Seq_LNCAP_Human0.96213983
137CTCF_27219007_Chip-Seq_Bcells_Human0.96100423
138SCL_19346495_ChIP-Seq_HPC-7_Human0.96029266
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95497703
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.95139666
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94899169
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.94805168
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94766666
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94696218
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.94012004
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93762122
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93451843
148* KDM2B_26808549_Chip-Seq_DND41_Human0.93117195
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92190269
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92010048
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.91849317
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91287464
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.90863791
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89980331
155BCAT_22108803_ChIP-Seq_LS180_Human0.89777710
156TCF4_18268006_ChIP-ChIP_LS174T_Human0.88677200
157RACK7_27058665_Chip-Seq_MCF-7_Human0.88653702
158JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88243069
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.87197239
160* GATA2_19941826_ChIP-Seq_K562_Human0.87160930
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86521850
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85711064
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85711064
164SOX2_20726797_ChIP-Seq_SW620_Human0.84861364
165RING1B_27294783_Chip-Seq_ESCs_Mouse0.84267234
166ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84207751
167SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82726618
168TP63_22573176_ChIP-Seq_HFKS_Human0.82670970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.04492384
2MP0001879_abnormal_lymphatic_vessel4.54314439
3MP0002837_dystrophic_cardiac_calcinosis4.52219328
4* MP0004084_abnormal_cardiac_muscle4.14704543
5MP0004272_abnormal_basement_membrane3.94627528
6MP0000751_myopathy3.62556229
7* MP0004215_abnormal_myocardial_fiber3.47077019
8* MP0005167_abnormal_blood-brain_barrier3.37449588
9MP0005330_cardiomyopathy3.12691999
10MP0003828_pulmonary_edema3.05735498
11* MP0004036_abnormal_muscle_relaxation2.90296770
12MP0005670_abnormal_white_adipose2.79602582
13MP0006138_congestive_heart_failure2.75642952
14MP0003646_muscle_fatigue2.71763248
15MP0004130_abnormal_muscle_cell2.49906198
16MP0000749_muscle_degeneration2.40563752
17* MP0002972_abnormal_cardiac_muscle2.38219999
18* MP0005410_abnormal_fertilization2.35602679
19* MP0001544_abnormal_cardiovascular_syste2.26088891
20* MP0005385_cardiovascular_system_phenoty2.26088891
21MP0010630_abnormal_cardiac_muscle2.22416645
22MP0004484_altered_response_of2.20634830
23MP0004087_abnormal_muscle_fiber2.15871267
24MP0002933_joint_inflammation2.14143490
25MP0000465_gastrointestinal_hemorrhage2.07599306
26* MP0005620_abnormal_muscle_contractility2.06655076
27MP0000750_abnormal_muscle_regeneration2.03616065
28* MP0008775_abnormal_heart_ventricle2.01777037
29MP0000013_abnormal_adipose_tissue2.00511576
30MP0005666_abnormal_adipose_tissue1.90102598
31* MP0004085_abnormal_heartbeat1.89060266
32MP0002332_abnormal_exercise_endurance1.80927115
33MP0003137_abnormal_impulse_conducting1.76519884
34MP0003279_aneurysm1.73670563
35MP0005623_abnormal_meninges_morphology1.70833092
36MP0003705_abnormal_hypodermis_morpholog1.62181965
37MP0005165_increased_susceptibility_to1.60842252
38MP0005375_adipose_tissue_phenotype1.56024233
39MP0002106_abnormal_muscle_physiology1.53928522
40MP0000767_abnormal_smooth_muscle1.53636619
41MP0004147_increased_porphyrin_level1.53138654
42MP0002254_reproductive_system_inflammat1.52687450
43MP0003878_abnormal_ear_physiology1.50692884
44MP0005377_hearing/vestibular/ear_phenot1.50692884
45MP0003950_abnormal_plasma_membrane1.48700573
46MP0004185_abnormal_adipocyte_glucose1.43175776
47* MP0002127_abnormal_cardiovascular_syste1.43156927
48MP0002132_abnormal_respiratory_system1.42506879
49MP0004145_abnormal_muscle_electrophysio1.41175075
50MP0000343_altered_response_to1.40539931
51MP0000678_abnormal_parathyroid_gland1.35168752
52MP0000003_abnormal_adipose_tissue1.35127205
53MP0001348_abnormal_lacrimal_gland1.34730603
54MP0008438_abnormal_cutaneous_collagen1.30191085
55MP0005369_muscle_phenotype1.29073422
56MP0003566_abnormal_cell_adhesion1.25736470
57MP0000759_abnormal_skeletal_muscle1.25445116
58MP0003724_increased_susceptibility_to1.24951168
59* MP0002128_abnormal_blood_circulation1.24517728
60MP0002269_muscular_atrophy1.24301269
61* MP0000266_abnormal_heart_morphology1.18944551
62MP0009780_abnormal_chondrocyte_physiolo1.11780069
63* MP0002925_abnormal_cardiovascular_devel1.09394739
64* MP0000249_abnormal_blood_vessel1.07082004
65MP0010030_abnormal_orbit_morphology1.06381034
66MP0000747_muscle_weakness1.04063888
67MP0006054_spinal_hemorrhage1.01277213
68MP0004510_myositis1.00955698
69MP0001501_abnormal_sleep_pattern1.00598746
70* MP0001614_abnormal_blood_vessel0.99791694
71MP0002876_abnormal_thyroid_physiology0.97630538
72* MP0000230_abnormal_systemic_arterial0.96361765
73MP0002638_abnormal_pupillary_reflex0.94994822
74* MP0005595_abnormal_vascular_smooth0.94990076
75MP0005551_abnormal_eye_electrophysiolog0.93504216
76MP0002971_abnormal_brown_adipose0.88202735
77MP0005275_abnormal_skin_tensile0.88069638
78MP0002168_other_aberrant_phenotype0.87979672
79MP0006036_abnormal_mitochondrial_physio0.87793081
80MP0003195_calcinosis0.87721641
81MP0003567_abnormal_fetal_cardiomyocyte0.86532266
82MP0003221_abnormal_cardiomyocyte_apopto0.86330802
83MP0002108_abnormal_muscle_morphology0.85368615
84MP0003122_maternal_imprinting0.84890778
85MP0003011_delayed_dark_adaptation0.83746236
86MP0010329_abnormal_lipoprotein_level0.82542408
87MP0005084_abnormal_gallbladder_morpholo0.81464457
88MP0003191_abnormal_cellular_cholesterol0.79687605
89MP0001784_abnormal_fluid_regulation0.76448109
90MP0001958_emphysema0.76307365
91MP0009278_abnormal_bone_marrow0.73640533
92MP0002138_abnormal_hepatobiliary_system0.73296188
93* MP0002295_abnormal_pulmonary_circulatio0.70043230
94MP0003698_abnormal_male_reproductive0.69504866
95MP0001661_extended_life_span0.68096244
96MP0004233_abnormal_muscle_weight0.67797490
97MP0009115_abnormal_fat_cell0.65493520
98MP0003303_peritoneal_inflammation0.65091061
99MP0008961_abnormal_basal_metabolism0.64735061
100MP0005187_abnormal_penis_morphology0.64659987
101MP0005360_urolithiasis0.63393373
102MP0009379_abnormal_foot_pigmentation0.61356044
103MP0005085_abnormal_gallbladder_physiolo0.61059668
104MP0004885_abnormal_endolymph0.60786144
105MP0001915_intracranial_hemorrhage0.59987904
106MP0008995_early_reproductive_senescence0.59042659
107* MP0002118_abnormal_lipid_homeostasis0.58797482
108MP0001486_abnormal_startle_reflex0.55766013
109MP0003119_abnormal_digestive_system0.55249071
110MP0009840_abnormal_foam_cell0.54944172
111MP0000613_abnormal_salivary_gland0.54385960
112MP0003984_embryonic_growth_retardation0.54161008
113MP0001929_abnormal_gametogenesis0.53910294
114MP0005388_respiratory_system_phenotype0.53772175
115MP0002133_abnormal_respiratory_system0.53772175
116MP0000733_abnormal_muscle_development0.53316498
117MP0002088_abnormal_embryonic_growth/wei0.53194911
118MP0003868_abnormal_feces_composition0.52790934
119MP0003091_abnormal_cell_migration0.52749440
120MP0008872_abnormal_physiological_respon0.52069823
121MP0003943_abnormal_hepatobiliary_system0.51942764
122MP0005266_abnormal_metabolism0.51713658
123MP0005334_abnormal_fat_pad0.51020826
124MP0005409_darkened_coat_color0.49859056
125MP0005365_abnormal_bile_salt0.49314849
126MP0003045_fibrosis0.49106111
127* MP0005319_abnormal_enzyme/_coenzyme0.48150921
128MP0000049_abnormal_middle_ear0.48062501
129MP0002909_abnormal_adrenal_gland0.47839312
130* MP0005535_abnormal_body_temperature0.46468527
131MP0001485_abnormal_pinna_reflex0.45926387
132MP0001756_abnormal_urination0.45059220
133* MP0003633_abnormal_nervous_system0.44456552
134MP0003690_abnormal_glial_cell0.44426423
135MP0003935_abnormal_craniofacial_develop0.44128590

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.47418533
2Ventricular tachycardia (HP:0004756)5.69576242
3Muscle fiber splitting (HP:0003555)5.66261804
4Atrial fibrillation (HP:0005110)5.04527139
5Supraventricular arrhythmia (HP:0005115)4.68271416
6Primary atrial arrhythmia (HP:0001692)4.66948513
7Hyporeflexia of lower limbs (HP:0002600)4.61079888
8Supraventricular tachycardia (HP:0004755)4.46946817
9Increased connective tissue (HP:0009025)4.43706447
10Lipoatrophy (HP:0100578)4.40498556
11Exercise-induced muscle cramps (HP:0003710)4.39495405
12Polycythemia (HP:0001901)4.15562750
13Calf muscle hypertrophy (HP:0008981)4.09081648
14Wrist flexion contracture (HP:0001239)4.03452547
15Right ventricular cardiomyopathy (HP:0011663)4.01555945
16Exercise-induced myalgia (HP:0003738)3.96851083
17Difficulty running (HP:0009046)3.90475284
18Syncope (HP:0001279)3.75915450
19Abnormality of the hepatic vasculature (HP:0006707)3.75798628
20Prolonged QT interval (HP:0001657)3.73500822
21Myoglobinuria (HP:0002913)3.69579850
22Muscle hypertrophy of the lower extremities (HP:0008968)3.69172185
23Subaortic stenosis (HP:0001682)3.61812921
24Abnormality of the left ventricular outflow tract (HP:0011103)3.61812921
25Atrioventricular block (HP:0001678)3.61631003
26Abnormality of the calf musculature (HP:0001430)3.61161416
27Dilated cardiomyopathy (HP:0001644)3.54608482
28Lymphangioma (HP:0100764)3.52734439
29Hypoglycemic coma (HP:0001325)3.42514591
30Palpitations (HP:0001962)3.35882495
31Heart block (HP:0012722)3.34480853
32EMG: myopathic abnormalities (HP:0003458)3.28039323
33Myotonia (HP:0002486)3.27275648
34Bundle branch block (HP:0011710)3.26055748
35High pitched voice (HP:0001620)3.25805405
36Bulbous nose (HP:0000414)3.19687298
37Abnormal atrioventricular conduction (HP:0005150)3.14845660
38Increased variability in muscle fiber diameter (HP:0003557)3.14215798
39Cerebral aneurysm (HP:0004944)3.08199223
40Pigmentary retinal degeneration (HP:0001146)3.08017282
41Cerebral hemorrhage (HP:0001342)3.06871342
42Asymmetric septal hypertrophy (HP:0001670)3.06126598
43Esophageal varix (HP:0002040)3.02145136
44Hematochezia (HP:0002573)3.01853272
45Ventricular arrhythmia (HP:0004308)3.00274356
46Broad metatarsal (HP:0001783)3.00250128
47Ventricular fibrillation (HP:0001663)2.95109004
48Difficulty climbing stairs (HP:0003551)2.82664984
49Rhabdomyolysis (HP:0003201)2.82247743
50Abnormality of skeletal muscle fiber size (HP:0012084)2.81213550
51Nephronophthisis (HP:0000090)2.77619628
52Congenital stationary night blindness (HP:0007642)2.75532100
53Conjunctival telangiectasia (HP:0000524)2.72013666
54Ketoacidosis (HP:0001993)2.70875112
55Type II lissencephaly (HP:0007260)2.69379117
56Spontaneous hematomas (HP:0007420)2.63844439
57Delayed CNS myelination (HP:0002188)2.63386749
58Visceral angiomatosis (HP:0100761)2.55476175
59Muscle stiffness (HP:0003552)2.51221677
60Abnormal EKG (HP:0003115)2.46097843
61Hyperinsulinemic hypoglycemia (HP:0000825)2.45304829
62Occipital encephalocele (HP:0002085)2.41506453
63Adactyly (HP:0009776)2.40982769
64Cavernous hemangioma (HP:0001048)2.40202734
65Abnormality of the renal medulla (HP:0100957)2.40146099
66Hemangiomatosis (HP:0007461)2.38530949
67Spinal rigidity (HP:0003306)2.32831276
68Hemorrhage of the eye (HP:0011885)2.29849532
69Scotoma (HP:0000575)2.28972914
70Exotropia (HP:0000577)2.28502772
71Capillary hemangiomas (HP:0005306)2.27815211
72Attenuation of retinal blood vessels (HP:0007843)2.26007329
73Congenital hepatic fibrosis (HP:0002612)2.25255447
74Hemiplegia (HP:0002301)2.23899213
75Polydipsia (HP:0001959)2.23876071
76Abnormal drinking behavior (HP:0030082)2.23876071
77Clumsiness (HP:0002312)2.21717083
78Acanthosis nigricans (HP:0000956)2.21373279
79Chronic hepatic failure (HP:0100626)2.21276447
80Abnormality of the vitreous humor (HP:0004327)2.20881399
81Absent hand (HP:0004050)2.20362264
82Pulmonary artery stenosis (HP:0004415)2.19416869
83Pancreatic cysts (HP:0001737)2.17411519
84Type 1 muscle fiber predominance (HP:0003803)2.17341345
85Aneurysm (HP:0002617)2.15072759
86Hyperglycinuria (HP:0003108)2.14918381
87Ketosis (HP:0001946)2.14653608
88Abnormality of fatty-acid metabolism (HP:0004359)2.14265485
89Molar tooth sign on MRI (HP:0002419)2.13546314
90Abnormality of midbrain morphology (HP:0002418)2.13546314
91Testicular atrophy (HP:0000029)2.12913767
92Distal lower limb muscle weakness (HP:0009053)2.12874968
93Stroke (HP:0001297)2.11275088
94Duplicated collecting system (HP:0000081)2.08862828
95Dicarboxylic aciduria (HP:0003215)2.08629971
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08629971
97Pancreatic islet-cell hyperplasia (HP:0004510)2.07309217
98Hyperventilation (HP:0002883)2.05600559
99Venous insufficiency (HP:0005293)2.05444398
100J-shaped sella turcica (HP:0002680)2.04065775
101Anterior segment dysgenesis (HP:0007700)2.02353004
102Hypoplasia of the iris (HP:0007676)2.02050307
103Tubular atrophy (HP:0000092)2.01515148
104Facial diplegia (HP:0001349)2.01483353
105Pancreatic fibrosis (HP:0100732)2.01446128
106Potter facies (HP:0002009)2.00648818
107Facial shape deformation (HP:0011334)2.00648818
108True hermaphroditism (HP:0010459)2.00351548
109Fair hair (HP:0002286)2.00325766
110Left ventricular hypertrophy (HP:0001712)1.99899568
111Conjunctival hamartoma (HP:0100780)1.99613470
112Areflexia of lower limbs (HP:0002522)1.98779466
113Hyperkalemia (HP:0002153)1.98102406
114Neonatal death (HP:0003811)1.97910144
115Absent speech (HP:0001344)1.96849404
116Joint hemorrhage (HP:0005261)1.96839913
117Neoplasm of the oral cavity (HP:0100649)1.95784777
118Porencephaly (HP:0002132)1.95040250
119Abnormality of the renal collecting system (HP:0004742)1.94274700
120Skull defect (HP:0001362)1.94249132
121Abnormality of the nasal mucosa (HP:0000433)1.94084011
122Mesangial abnormality (HP:0001966)1.89907391
123Palmoplantar keratoderma (HP:0000982)1.89806919
124Bone cyst (HP:0012062)1.88254698
125Nonimmune hydrops fetalis (HP:0001790)1.87837842
126Cystic liver disease (HP:0006706)1.85848016
127Congestive heart failure (HP:0001635)1.85285005
128Deep venous thrombosis (HP:0002625)1.85272017
129Hyperammonemia (HP:0001987)1.84368933
130Increased muscle lipid content (HP:0009058)1.84355180
131Subcapsular cataract (HP:0000523)1.84016179
132Decreased circulating renin level (HP:0003351)1.83640822
133Hypoalphalipoproteinemia (HP:0003233)1.82652038
134Hip contracture (HP:0003273)1.82346649
135Hepatic necrosis (HP:0002605)1.81136120
136Hypoplastic ischia (HP:0003175)1.81112406
137Sudden cardiac death (HP:0001645)1.80235825
138Muscular dystrophy (HP:0003560)1.79570976
139Abnormality of femoral epiphyses (HP:0006499)1.79094709
140Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.79094709
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.78861471
142Absent/shortened dynein arms (HP:0200106)1.78861471
143Dysautonomia (HP:0002459)1.78405033
144Large for gestational age (HP:0001520)1.78121878
145Portal hypertension (HP:0001409)1.78040269
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77457406
147Protrusio acetabuli (HP:0003179)1.74521595
148Birth length less than 3rd percentile (HP:0003561)1.74460701
149Ulnar claw (HP:0001178)1.74316768
150Abnormal urine output (HP:0012590)1.73848380
151Hamartoma of the eye (HP:0010568)1.72973029
152Asymmetry of the thorax (HP:0001555)1.72853061
153Large hands (HP:0001176)1.72741475
154Generalized muscle weakness (HP:0003324)1.72015886
155Limb-girdle muscle atrophy (HP:0003797)1.71916234
156Stage 5 chronic kidney disease (HP:0003774)1.71348494
157Ileus (HP:0002595)1.69910879
158Abnormality of the renal cortex (HP:0011035)1.69804097
159Polyuria (HP:0000103)1.69571948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.61012745
2KDR5.78266245
3TTN2.97284730
4TGFBR22.96654042
5MYLK2.78012714
6FRK2.47951057
7TRIB32.41572298
8RIPK12.32854644
9PKN22.06450609
10PDK22.04659596
11FES2.01553052
12LMTK22.01079245
13DMPK1.87058914
14PHKG21.78004758
15PHKG11.78004758
16PDK31.77872874
17PDK41.77872874
18BCKDK1.77572043
19EPHB21.57412327
20OBSCN1.57331003
21GRK11.47749377
22INSRR1.42354533
23TGFBR11.37710867
24TEC1.36296714
25BMPR1B1.34705507
26MAPK121.30851386
27PRKD11.25026730
28MAP2K31.20335192
29CAMK1D1.18393246
30NTRK31.14837093
31FER1.10142322
32PTK61.08841203
33PRKD31.06126852
34ERN11.03909699
35PLK40.99926135
36CAMK1G0.98308119
37PDGFRA0.98231674
38FGFR20.92714825
39MAP3K30.92574088
40WNK40.90876849
41PIK3CA0.89335463
42PAK30.81908426
43DAPK20.79988583
44ILK0.79870521
45EPHB10.78434934
46SIK10.78337391
47EEF2K0.77430192
48ADRBK20.75772677
49NME10.74871773
50PINK10.72429643
51MAPK150.71895177
52ACVR1B0.71039308
53STK240.66621719
54MAPKAPK30.65672625
55AKT30.65648671
56ROCK10.65199164
57FGFR40.64898255
58ZAP700.64822162
59MAPK70.64063374
60MAP3K70.63079099
61EPHA30.61975658
62NEK10.61083523
63STK38L0.60946630
64PRKCH0.60918551
65PLK20.56948729
66* PRKAA20.56031728
67NLK0.55622273
68PDPK10.54159337
69PAK40.53577773
70NTRK10.53051920
71OXSR10.52833773
72MAP4K20.52438146
73MET0.52405890
74DAPK30.51479824
75PTK20.51457971
76CAMK2D0.51110173
77STK390.49766818
78PIK3CG0.48761246
79PAK20.47860160
80CAMK40.47161186
81* PTK2B0.46908756
82MAP4K10.45626557
83FGFR30.45268577
84PRKCE0.44428025
85CAMK10.44378976
86RET0.44100540
87RPS6KA20.42328773
88GRK70.42247522
89GSK3A0.41987525
90CDC42BPA0.41973315
91MAP2K20.41330004
92TNK20.40870913
93MAP3K110.40784909
94* PRKAA10.39823578
95MAP3K10.38142260
96ITK0.36877205
97MAP2K10.36731805
98IGF1R0.36711251
99MUSK0.35511677
100MAPK130.34731392
101BMX0.34262414
102PKN10.33251817
103HCK0.32883050
104MAP2K60.32828461
105TNIK0.31075694
106ADRBK10.30969292
107PRKACB0.30477308
108ICK0.30438714
109MTOR0.30232943
110WNK10.30027343
111CAMK2A0.29555932
112PDK10.29153946
113LRRK20.28821930
114JAK30.28429842
115MARK20.27764045
116MAPKAPK50.27593898
117PDGFRB0.27532870
118MST40.27053749
119AKT20.27008503
120* SRC0.26801189
121PRKG10.26654736
122ROCK20.26618193
123* PRKACG0.25218397
124PRKD20.24095290
125EGFR0.23961569
126BTK0.23703764
127STK110.23692923
128TAOK30.23244472
129JAK20.21601070
130STK380.21131040
131TRPM70.20815850
132MAP3K60.20501794
133FLT30.20337629
134MAP2K40.19985843
135SGK20.19761825
136CSK0.19696214
137INSR0.19281599
138* PRKACA0.19049364
139BRSK20.19040848
140RPS6KC10.19029998
141NEK20.18783060
142RPS6KA60.18474802
143EPHA20.17206106
144STK30.17013199
145MAPK10.16204245
146SGK2230.15715343
147SGK4940.15715343

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.16193855
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.56205461
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.26093917
4Propanoate metabolism_Homo sapiens_hsa006403.02336939
5Dilated cardiomyopathy_Homo sapiens_hsa054142.93730402
6Fatty acid degradation_Homo sapiens_hsa000712.71246419
7Cardiac muscle contraction_Homo sapiens_hsa042602.56732003
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.56678932
9Fatty acid metabolism_Homo sapiens_hsa012122.29198201
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28372985
11PPAR signaling pathway_Homo sapiens_hsa033202.23797786
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22712259
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09536821
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.01559418
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.98363188
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95686830
17Phototransduction_Homo sapiens_hsa047441.93799445
18Olfactory transduction_Homo sapiens_hsa047401.92285731
19Linoleic acid metabolism_Homo sapiens_hsa005911.84022052
20ECM-receptor interaction_Homo sapiens_hsa045121.79303579
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73426651
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71914608
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63478211
24Carbon metabolism_Homo sapiens_hsa012001.62704680
25Nitrogen metabolism_Homo sapiens_hsa009101.62059946
26Focal adhesion_Homo sapiens_hsa045101.62033652
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.61977157
28Parkinsons disease_Homo sapiens_hsa050121.53623614
29Pyruvate metabolism_Homo sapiens_hsa006201.47669719
30Selenocompound metabolism_Homo sapiens_hsa004501.46493662
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42912596
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40460894
33Oxidative phosphorylation_Homo sapiens_hsa001901.36755737
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33605537
35Taste transduction_Homo sapiens_hsa047421.32482646
36Fatty acid biosynthesis_Homo sapiens_hsa000611.30415075
37Butanoate metabolism_Homo sapiens_hsa006501.28108635
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.27039256
39Morphine addiction_Homo sapiens_hsa050321.26839432
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25885643
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25628507
42Bile secretion_Homo sapiens_hsa049761.23989699
43Regulation of autophagy_Homo sapiens_hsa041401.22333065
44Dorso-ventral axis formation_Homo sapiens_hsa043201.22027057
45Ether lipid metabolism_Homo sapiens_hsa005651.20559369
46Adherens junction_Homo sapiens_hsa045201.17232566
47Fatty acid elongation_Homo sapiens_hsa000621.16957981
48Alzheimers disease_Homo sapiens_hsa050101.13841599
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10542456
50Serotonergic synapse_Homo sapiens_hsa047261.09441695
51Viral myocarditis_Homo sapiens_hsa054161.08471723
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07860075
53Renin secretion_Homo sapiens_hsa049241.06057466
54* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03906688
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03551623
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03304456
57* Insulin resistance_Homo sapiens_hsa049311.02605363
58Tryptophan metabolism_Homo sapiens_hsa003801.01949796
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.00670033
60Tight junction_Homo sapiens_hsa045300.97732697
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.97617690
62Circadian rhythm_Homo sapiens_hsa047100.94907118
63Glutamatergic synapse_Homo sapiens_hsa047240.94878426
64Glucagon signaling pathway_Homo sapiens_hsa049220.94846045
65Retinol metabolism_Homo sapiens_hsa008300.92802447
66AMPK signaling pathway_Homo sapiens_hsa041520.88809672
67beta-Alanine metabolism_Homo sapiens_hsa004100.88667183
68* Arginine biosynthesis_Homo sapiens_hsa002200.88550286
69Complement and coagulation cascades_Homo sapiens_hsa046100.87059988
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86476836
71Chemical carcinogenesis_Homo sapiens_hsa052040.86201594
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86021498
73Amoebiasis_Homo sapiens_hsa051460.86019571
74Huntingtons disease_Homo sapiens_hsa050160.85305764
75Rap1 signaling pathway_Homo sapiens_hsa040150.83883212
76Sulfur relay system_Homo sapiens_hsa041220.83580764
77Fat digestion and absorption_Homo sapiens_hsa049750.79901267
78Arachidonic acid metabolism_Homo sapiens_hsa005900.79733435
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79052658
80Ovarian steroidogenesis_Homo sapiens_hsa049130.78603382
81cAMP signaling pathway_Homo sapiens_hsa040240.76099956
82Glycerolipid metabolism_Homo sapiens_hsa005610.75258802
83Notch signaling pathway_Homo sapiens_hsa043300.74280358
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.74119848
85GABAergic synapse_Homo sapiens_hsa047270.73872376
86Protein digestion and absorption_Homo sapiens_hsa049740.73869930
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73769070
88Peroxisome_Homo sapiens_hsa041460.70492950
89Gastric acid secretion_Homo sapiens_hsa049710.69742831
90Insulin signaling pathway_Homo sapiens_hsa049100.68447813
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66179931
92Inositol phosphate metabolism_Homo sapiens_hsa005620.65792165
93Mineral absorption_Homo sapiens_hsa049780.65615297
94Starch and sucrose metabolism_Homo sapiens_hsa005000.64942718
95* HIF-1 signaling pathway_Homo sapiens_hsa040660.64558945
96Gap junction_Homo sapiens_hsa045400.64468000
97Histidine metabolism_Homo sapiens_hsa003400.63664262
98* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63539931
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.63246077
100Renal cell carcinoma_Homo sapiens_hsa052110.61568578
101Small cell lung cancer_Homo sapiens_hsa052220.61238472
102Proteoglycans in cancer_Homo sapiens_hsa052050.59898848
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59845937
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59740019
105Phenylalanine metabolism_Homo sapiens_hsa003600.58948045
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58560886
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58429106
108* Oxytocin signaling pathway_Homo sapiens_hsa049210.58357661
109Lysine degradation_Homo sapiens_hsa003100.58143786
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57940489
111Insulin secretion_Homo sapiens_hsa049110.57304057
112Thyroid hormone synthesis_Homo sapiens_hsa049180.55788539
113* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55664507
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54787672
115Basal transcription factors_Homo sapiens_hsa030220.52310791
116Biosynthesis of amino acids_Homo sapiens_hsa012300.52184212
117TGF-beta signaling pathway_Homo sapiens_hsa043500.50115546
118Circadian entrainment_Homo sapiens_hsa047130.49894368
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49814250
120Malaria_Homo sapiens_hsa051440.49737786
121* Calcium signaling pathway_Homo sapiens_hsa040200.49333231
122* Platelet activation_Homo sapiens_hsa046110.48984470
123ABC transporters_Homo sapiens_hsa020100.48886483
124Choline metabolism in cancer_Homo sapiens_hsa052310.47653308
125Axon guidance_Homo sapiens_hsa043600.47373926
126Salivary secretion_Homo sapiens_hsa049700.45766337
127* Arginine and proline metabolism_Homo sapiens_hsa003300.44013775
128GnRH signaling pathway_Homo sapiens_hsa049120.43124857
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43021707
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42277643
131Sphingolipid metabolism_Homo sapiens_hsa006000.41888439
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41855592
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41790386
134Melanogenesis_Homo sapiens_hsa049160.41460145
135Ras signaling pathway_Homo sapiens_hsa040140.40933667
136Glutathione metabolism_Homo sapiens_hsa004800.40517136
137* Estrogen signaling pathway_Homo sapiens_hsa049150.39864877
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.38218731
139Tyrosine metabolism_Homo sapiens_hsa003500.36752565
140Caffeine metabolism_Homo sapiens_hsa002320.35943850
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35935627
142Type II diabetes mellitus_Homo sapiens_hsa049300.35235274
143Cholinergic synapse_Homo sapiens_hsa047250.34047120
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33698195
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33622700
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.30499831
147Pathways in cancer_Homo sapiens_hsa052000.29741935

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