NOSIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.75463577
2DNA deamination (GO:0045006)5.59413211
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.81485374
4maturation of SSU-rRNA (GO:0030490)4.77568184
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69099127
6negative T cell selection (GO:0043383)4.51695388
7ribosomal small subunit biogenesis (GO:0042274)4.42059964
8negative regulation of cell killing (GO:0031342)4.41177850
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41177850
10viral transcription (GO:0019083)4.41163277
11formation of translation preinitiation complex (GO:0001731)4.38592996
12proteasome assembly (GO:0043248)4.33033916
13DNA strand elongation involved in DNA replication (GO:0006271)4.25529468
14translational termination (GO:0006415)4.24158508
15telomere maintenance via semi-conservative replication (GO:0032201)4.20939531
16negative thymic T cell selection (GO:0045060)4.13467550
17ribosomal large subunit biogenesis (GO:0042273)4.12356014
18positive regulation of gamma-delta T cell activation (GO:0046645)4.11101873
19DNA strand elongation (GO:0022616)4.03563690
20ribonucleoprotein complex biogenesis (GO:0022613)4.02348123
21translational elongation (GO:0006414)4.02149483
22antigen processing and presentation of endogenous antigen (GO:0019883)4.00650999
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95571130
24ribosome biogenesis (GO:0042254)3.93679894
25cytidine metabolic process (GO:0046087)3.88296170
26cytidine catabolic process (GO:0006216)3.88296170
27cytidine deamination (GO:0009972)3.88296170
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.87734467
29termination of RNA polymerase III transcription (GO:0006386)3.87734467
30response to interferon-beta (GO:0035456)3.87102100
31nucleobase biosynthetic process (GO:0046112)3.86240443
32purine nucleobase biosynthetic process (GO:0009113)3.79237051
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79061508
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78462991
35translational initiation (GO:0006413)3.78122318
36positive thymic T cell selection (GO:0045059)3.77856938
37DNA replication initiation (GO:0006270)3.77653701
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75728971
39telomere maintenance via recombination (GO:0000722)3.67964632
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65204471
41positive T cell selection (GO:0043368)3.62657129
42NIK/NF-kappaB signaling (GO:0038061)3.62505620
43regulation of B cell receptor signaling pathway (GO:0050855)3.57400191
44negative regulation of ligase activity (GO:0051352)3.57237526
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57237526
46spliceosomal snRNP assembly (GO:0000387)3.56828924
47T cell migration (GO:0072678)3.56153187
48cotranslational protein targeting to membrane (GO:0006613)3.55896372
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54843967
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54668140
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54537569
52leukocyte aggregation (GO:0070486)3.52871335
53protein targeting to ER (GO:0045047)3.52682509
54cellular protein complex disassembly (GO:0043624)3.52098998
55purine deoxyribonucleotide catabolic process (GO:0009155)3.50803948
567-methylguanosine mRNA capping (GO:0006370)3.50408454
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50320752
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49304607
59viral life cycle (GO:0019058)3.49303858
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49108494
61ATP synthesis coupled proton transport (GO:0015986)3.49108494
62thymic T cell selection (GO:0045061)3.47927998
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.47652826
64transcription-coupled nucleotide-excision repair (GO:0006283)3.47593002
65rRNA processing (GO:0006364)3.45427018
66RNA capping (GO:0036260)3.40461188
677-methylguanosine RNA capping (GO:0009452)3.40461188
68rRNA modification (GO:0000154)3.37777477
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37496356
70protein localization to endoplasmic reticulum (GO:0070972)3.37275470
71IMP biosynthetic process (GO:0006188)3.35377221
72telomere maintenance via telomere lengthening (GO:0010833)3.34475498
73rRNA metabolic process (GO:0016072)3.32959136
74translation (GO:0006412)3.32884544
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32830381
76termination of RNA polymerase I transcription (GO:0006363)3.32018763
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30592251
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30421961
79regulation of mitochondrial translation (GO:0070129)3.30307365
80DNA replication checkpoint (GO:0000076)3.29398654
81pseudouridine synthesis (GO:0001522)3.28910706
82mitotic recombination (GO:0006312)3.28232132
83T cell selection (GO:0045058)3.27498101
84positive regulation of B cell differentiation (GO:0045579)3.27447628
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26346575
86cellular component biogenesis (GO:0044085)3.26224359
87protein complex disassembly (GO:0043241)3.23845721
88transcription from RNA polymerase I promoter (GO:0006360)3.23496524
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22955525
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22955525
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22955525
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22503844
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22503844
94protein complex biogenesis (GO:0070271)3.22077196
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19565063
96regulation of B cell differentiation (GO:0045577)3.19468277
97signal transduction involved in DNA damage checkpoint (GO:0072422)3.19207546
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19207546
99IMP metabolic process (GO:0046040)3.16477353
100negative regulation of B cell apoptotic process (GO:0002903)3.15568243
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.14266787
102maturation of 5.8S rRNA (GO:0000460)3.13753767
103regulation of T cell mediated cytotoxicity (GO:0001914)3.13368729
104cellular response to interferon-beta (GO:0035458)3.12581735
105macromolecular complex disassembly (GO:0032984)3.10915211
106positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10726505
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09073082
108respiratory electron transport chain (GO:0022904)3.09032969
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07895389
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06970861
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06970861
112mitochondrial respiratory chain complex assembly (GO:0033108)3.06688697
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.06473814
114regulation of cellular amino acid metabolic process (GO:0006521)3.06434943
115spliceosomal complex assembly (GO:0000245)3.04393512
116immunoglobulin mediated immune response (GO:0016064)3.04343597
117sequestering of actin monomers (GO:0042989)3.03989011
118regulation of alpha-beta T cell proliferation (GO:0046640)3.03897477
119actin nucleation (GO:0045010)3.03728597
120mitochondrial respiratory chain complex I assembly (GO:0032981)3.03147212
121NADH dehydrogenase complex assembly (GO:0010257)3.03147212
122mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03147212
123transcription elongation from RNA polymerase I promoter (GO:0006362)3.02648440
124electron transport chain (GO:0022900)3.02292904
125regulation of gamma-delta T cell differentiation (GO:0045586)3.01991774
126ribosome assembly (GO:0042255)2.99365650
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99188798
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98424087
129respiratory burst (GO:0045730)2.96194999
130positive regulation of ligase activity (GO:0051351)2.93382792
131purine nucleotide salvage (GO:0032261)2.93184410
132DNA damage response, detection of DNA damage (GO:0042769)2.93039523
133mitotic metaphase plate congression (GO:0007080)2.91550794
134nucleotide salvage (GO:0043173)2.91475040
135regulation of T cell tolerance induction (GO:0002664)2.91199671
136mast cell activation (GO:0045576)2.89587749
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.89028058
138cellular response to interleukin-15 (GO:0071350)2.87759438
139regulation of gamma-delta T cell activation (GO:0046643)2.84835065
140deoxyribonucleotide catabolic process (GO:0009264)2.83545381
141DNA-templated transcription, termination (GO:0006353)2.83476107
142establishment of protein localization to mitochondrial membrane (GO:0090151)2.83160535
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.81294883
144purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.80610540
145G1/S transition of mitotic cell cycle (GO:0000082)2.80224224
146cell cycle G1/S phase transition (GO:0044843)2.80224224
147antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79903011
148protein deneddylation (GO:0000338)2.78986001
149deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.78638072
150regulation of regulatory T cell differentiation (GO:0045589)2.78354811
151DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78319005
152GDP-mannose metabolic process (GO:0019673)2.77802798
153transcription initiation from RNA polymerase I promoter (GO:0006361)2.77692230
154regulation of ligase activity (GO:0051340)2.77596010
155viral mRNA export from host cell nucleus (GO:0046784)2.77297293
156nuclear-transcribed mRNA catabolic process (GO:0000956)2.76266087
157mast cell activation involved in immune response (GO:0002279)2.75035412
158mast cell degranulation (GO:0043303)2.75035412
159T cell receptor signaling pathway (GO:0050852)2.74707453
160negative regulation of T cell apoptotic process (GO:0070233)2.74698807
161iron-sulfur cluster assembly (GO:0016226)2.74688569
162metallo-sulfur cluster assembly (GO:0031163)2.74688569
163amino acid salvage (GO:0043102)2.73303236
164L-methionine salvage (GO:0071267)2.73303236
165L-methionine biosynthetic process (GO:0071265)2.73303236
166positive regulation of cell cycle arrest (GO:0071158)2.73128701
167negative regulation of lymphocyte apoptotic process (GO:0070229)2.72044682
168protein localization to kinetochore (GO:0034501)2.71445424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.44366809
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80493240
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.65206644
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42222224
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37982321
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.20297117
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12226393
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.11141808
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.09534792
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.07958786
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.07898179
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03304824
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83036222
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68197329
15* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59425925
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56718994
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50482104
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46882699
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43686837
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37393508
21* XRN2_22483619_ChIP-Seq_HELA_Human2.36132675
22* VDR_23849224_ChIP-Seq_CD4+_Human2.28291713
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.27085951
24* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21956127
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12939709
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05922723
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05613579
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.05265354
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05029496
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98147977
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94719252
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94083642
33* GABP_19822575_ChIP-Seq_HepG2_Human1.93981080
34UTX_26944678_Chip-Seq_JUKART_Human1.91910080
35DCP1A_22483619_ChIP-Seq_HELA_Human1.90536943
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88741172
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.88275054
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77340376
39MAF_26560356_Chip-Seq_TH1_Human1.76760564
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76760408
41* SRF_21415370_ChIP-Seq_HL-1_Mouse1.74967806
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74477555
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.74437759
44MYB_26560356_Chip-Seq_TH2_Human1.73960218
45TTF2_22483619_ChIP-Seq_HELA_Human1.71381974
46MYC_22102868_ChIP-Seq_BL_Human1.69057668
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68932583
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68540701
49CIITA_25753668_ChIP-Seq_RAJI_Human1.67326269
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64205201
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63154514
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55749686
53* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55293561
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.54327980
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53304437
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50974566
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49470187
58MYB_26560356_Chip-Seq_TH1_Human1.48749895
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47784571
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46742102
61VDR_21846776_ChIP-Seq_THP-1_Human1.45215935
62* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44250312
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43617791
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41829188
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39347314
66ELK1_19687146_ChIP-ChIP_HELA_Human1.38824513
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38291850
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37553158
69BCOR_27268052_Chip-Seq_Bcells_Human1.36390538
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35868813
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35556398
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34815859
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32177196
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31691409
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31536390
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.30459880
77RUNX_20019798_ChIP-Seq_JUKART_Human1.30311200
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30194955
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29933927
80KDM5A_27292631_Chip-Seq_BREAST_Human1.28499775
81* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28450749
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28308229
83VDR_24763502_ChIP-Seq_THP-1_Human1.28273328
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27227727
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26122789
86P68_20966046_ChIP-Seq_HELA_Human1.25251967
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24753709
88* SPI1_23547873_ChIP-Seq_NB4_Human1.23169477
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23002338
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22974778
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22928450
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22222144
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21676172
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.20213304
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17751315
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16163465
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.15441780
98E2F1_20622854_ChIP-Seq_HELA_Human1.15409997
99PHF8_20622854_ChIP-Seq_HELA_Human1.13268124
100* GATA3_27048872_Chip-Seq_THYMUS_Human1.12710973
101P300_27268052_Chip-Seq_Bcells_Human1.09903768
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08804901
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08515489
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08373403
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07349552
106* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06323069
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.06292304
108ELK1_22589737_ChIP-Seq_MCF10A_Human1.06150629
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05997656
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04972146
111GATA3_26560356_Chip-Seq_TH2_Human1.04841165
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.04541068
113LXR_22292898_ChIP-Seq_THP-1_Human1.04021483
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.03634740
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03466131
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.02741650
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01582543
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01449977
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01309507
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.01008197
121SA1_27219007_Chip-Seq_Bcells_Human1.00726492
122AR_21909140_ChIP-Seq_LNCAP_Human0.97447730
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97222887
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96868472
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96551760
126* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96301131
127* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95923732
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95786554
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94552178
130TFEB_21752829_ChIP-Seq_HELA_Human0.94278768
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.92065033
132MAF_26560356_Chip-Seq_TH2_Human0.90587879
133BCL6_27268052_Chip-Seq_Bcells_Human0.90236487
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89790859
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88886219
136* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87115956
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86103450
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85950372
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85510405
140STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83983442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86961633
2MP0003111_abnormal_nucleus_morphology4.09673401
3MP0004957_abnormal_blastocyst_morpholog3.93687747
4MP0003077_abnormal_cell_cycle3.41111011
5MP0010094_abnormal_chromosome_stability3.40517492
6MP0008058_abnormal_DNA_repair3.00764506
7MP0008007_abnormal_cellular_replicative2.90288657
8MP0002396_abnormal_hematopoietic_system2.88328501
9MP0003724_increased_susceptibility_to2.67377577
10MP0003786_premature_aging2.54593776
11MP0003763_abnormal_thymus_physiology2.34003583
12MP0008932_abnormal_embryonic_tissue2.20490711
13MP0008057_abnormal_DNA_replication2.18916392
14MP0002419_abnormal_innate_immunity2.16894129
15MP0008877_abnormal_DNA_methylation2.13710647
16MP0009333_abnormal_splenocyte_physiolog2.01320168
17MP0002132_abnormal_respiratory_system1.98132947
18MP0005397_hematopoietic_system_phenotyp1.97138292
19MP0001545_abnormal_hematopoietic_system1.97138292
20MP0005075_abnormal_melanosome_morpholog1.87934742
21MP0001835_abnormal_antigen_presentation1.86724798
22MP0002277_abnormal_respiratory_mucosa1.82898956
23MP0002398_abnormal_bone_marrow1.81058352
24MP0000490_abnormal_crypts_of1.80984750
25MP0001986_abnormal_taste_sensitivity1.75800081
26MP0004808_abnormal_hematopoietic_stem1.73589821
27MP0000685_abnormal_immune_system1.73396884
28MP0002163_abnormal_gland_morphology1.69858925
29MP0000689_abnormal_spleen_morphology1.67987088
30MP0001845_abnormal_inflammatory_respons1.67631214
31MP0002722_abnormal_immune_system1.65556514
32MP0005671_abnormal_response_to1.62718201
33MP0000350_abnormal_cell_proliferation1.61368208
34MP0001730_embryonic_growth_arrest1.59140771
35MP0000313_abnormal_cell_death1.55203488
36MP0003866_abnormal_defecation1.54325429
37MP0003718_maternal_effect1.54168214
38MP0002019_abnormal_tumor_incidence1.53434073
39MP0004381_abnormal_hair_follicle1.51982195
40MP0009785_altered_susceptibility_to1.49263023
41MP0001853_heart_inflammation1.49230864
42MP0000703_abnormal_thymus_morphology1.48676015
43MP0002653_abnormal_ependyma_morphology1.47146745
44MP0009764_decreased_sensitivity_to1.46510937
45MP0001800_abnormal_humoral_immune1.44182264
46MP0000372_irregular_coat_pigmentation1.44108036
47MP0002429_abnormal_blood_cell1.43207577
48MP0008469_abnormal_protein_level1.41440225
49MP0006292_abnormal_olfactory_placode1.40330539
50MP0000716_abnormal_immune_system1.38120644
51MP0006036_abnormal_mitochondrial_physio1.36692648
52MP0002420_abnormal_adaptive_immunity1.34044149
53MP0000858_altered_metastatic_potential1.33799233
54MP0002405_respiratory_system_inflammati1.32416309
55MP0001533_abnormal_skeleton_physiology1.31088766
56MP0001819_abnormal_immune_cell1.30500247
57MP0003191_abnormal_cellular_cholesterol1.25833268
58MP0001697_abnormal_embryo_size1.21666231
59MP0005025_abnormal_response_to1.20931605
60MP0001764_abnormal_homeostasis1.20718987
61MP0002723_abnormal_immune_serum1.20003891
62MP0002452_abnormal_antigen_presenting1.19955184
63MP0002080_prenatal_lethality1.19874648
64MP0002933_joint_inflammation1.19239476
65MP0009379_abnormal_foot_pigmentation1.18473776
66MP0003011_delayed_dark_adaptation1.17982406
67MP0004133_heterotaxia1.15632462
68MP0005464_abnormal_platelet_physiology1.13918281
69MP0001790_abnormal_immune_system1.12085179
70MP0005387_immune_system_phenotype1.12085179
71MP0003186_abnormal_redox_activity1.10935079
72MP0005084_abnormal_gallbladder_morpholo1.10089516
73MP0005380_embryogenesis_phenotype1.09765157
74MP0001672_abnormal_embryogenesis/_devel1.09765157
75MP0001663_abnormal_digestive_system1.07976565
76MP0005000_abnormal_immune_tolerance1.07580316
77MP0001873_stomach_inflammation1.07061736
78MP0002138_abnormal_hepatobiliary_system1.03991250
79MP0008260_abnormal_autophagy1.00268518
80MP0002210_abnormal_sex_determination1.00167145
81MP0004947_skin_inflammation0.99867170
82MP0009278_abnormal_bone_marrow0.99824045
83MP0003984_embryonic_growth_retardation0.96465350
84MP0005310_abnormal_salivary_gland0.96435837
85MP0000358_abnormal_cell_content/0.95807979
86MP0001929_abnormal_gametogenesis0.94973042
87MP0005083_abnormal_biliary_tract0.93918036
88MP0002088_abnormal_embryonic_growth/wei0.93541641
89MP0008872_abnormal_physiological_respon0.92924965
90MP0010155_abnormal_intestine_physiology0.91907647
91MP0001145_abnormal_male_reproductive0.89561841
92MP0002085_abnormal_embryonic_tissue0.89426895
93MP0003303_peritoneal_inflammation0.87662986
94MP0003646_muscle_fatigue0.87268400
95MP0002148_abnormal_hypersensitivity_rea0.87193459
96MP0003315_abnormal_perineum_morphology0.85061994
97MP0001348_abnormal_lacrimal_gland0.83999207
98MP0009763_increased_sensitivity_to0.82782680
99MP0002160_abnormal_reproductive_system0.82672298
100MP0005451_abnormal_body_composition0.82398967
101MP0001905_abnormal_dopamine_level0.82275401
102MP0001919_abnormal_reproductive_system0.82058366
103MP0009840_abnormal_foam_cell0.81839110
104MP0006082_CNS_inflammation0.81788929
105MP0003567_abnormal_fetal_cardiomyocyte0.81496816
106MP0005410_abnormal_fertilization0.81293379
107MP0006035_abnormal_mitochondrial_morpho0.80772478
108MP0003075_altered_response_to0.78882977
109MP0000477_abnormal_intestine_morphology0.78695867
110MP0004145_abnormal_muscle_electrophysio0.78584074
111MP0005166_decreased_susceptibility_to0.77220194
112MP0003436_decreased_susceptibility_to0.74842493
113MP0002095_abnormal_skin_pigmentation0.74657202
114MP0002084_abnormal_developmental_patter0.74006102
115MP0000343_altered_response_to0.73169150
116MP0009765_abnormal_xenobiotic_induced0.72666753
117MP0003806_abnormal_nucleotide_metabolis0.71802217
118MP0008995_early_reproductive_senescence0.69897803
119MP0002332_abnormal_exercise_endurance0.68640657
120MP0000465_gastrointestinal_hemorrhage0.68086727
121MP0008873_increased_physiological_sensi0.67057651
122MP0005319_abnormal_enzyme/_coenzyme0.66341222
123MP0000015_abnormal_ear_pigmentation0.65820604
124MP0001542_abnormal_bone_strength0.65272548
125MP0005384_cellular_phenotype0.65268137
126MP0002693_abnormal_pancreas_physiology0.65153152
127MP0005266_abnormal_metabolism0.65012409
128MP0000653_abnormal_sex_gland0.64831358
129MP0005501_abnormal_skin_physiology0.64138430
130MP0010352_gastrointestinal_tract_polyps0.63953833
131MP0002086_abnormal_extraembryonic_tissu0.63287293
132MP0003221_abnormal_cardiomyocyte_apopto0.63065675
133MP0005381_digestive/alimentary_phenotyp0.62674594
134MP0005023_abnormal_wound_healing0.62275933
135MP0003123_paternal_imprinting0.61592407
136MP0005621_abnormal_cell_physiology0.61405498
137MP0000750_abnormal_muscle_regeneration0.59961922
138MP0005379_endocrine/exocrine_gland_phen0.59696657
139MP0005376_homeostasis/metabolism_phenot0.58920046
140MP0002166_altered_tumor_susceptibility0.57197531
141MP0005390_skeleton_phenotype0.55448675
142MP0003638_abnormal_response/metabolism_0.55426814
143MP0001968_abnormal_touch/_nociception0.54249179
144MP0009643_abnormal_urine_homeostasis0.53935078
145MP0003300_gastrointestinal_ulcer0.53654992

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)3.96530202
2Abnormality of cells of the erythroid lineage (HP:0012130)3.95920439
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.95309073
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.95309073
5Stomatitis (HP:0010280)3.95163466
6Nasal polyposis (HP:0100582)3.87913911
7Cerebral hypomyelination (HP:0006808)3.86385824
8Abnormal number of erythroid precursors (HP:0012131)3.81977285
9Abnormality of the anterior horn cell (HP:0006802)3.76910378
10Degeneration of anterior horn cells (HP:0002398)3.76910378
11Aplastic anemia (HP:0001915)3.49560357
12Acute encephalopathy (HP:0006846)3.45298190
13Increased intramyocellular lipid droplets (HP:0012240)3.43921701
14Thrombocytosis (HP:0001894)3.38552715
15Carpal bone hypoplasia (HP:0001498)3.37626867
16Birth length less than 3rd percentile (HP:0003561)3.35780995
17Obstructive lung disease (HP:0006536)3.33057897
18Chronic obstructive pulmonary disease (HP:0006510)3.33057897
19Abnormality of the nasal mucosa (HP:0000433)3.32909878
20Reticulocytopenia (HP:0001896)3.29085318
21Recurrent abscess formation (HP:0002722)3.28651138
22T lymphocytopenia (HP:0005403)3.26531781
23Progressive macrocephaly (HP:0004481)3.26054196
24Eczematoid dermatitis (HP:0000976)3.25308213
25Microretrognathia (HP:0000308)3.23794994
26Myositis (HP:0100614)3.18760902
27Increased muscle lipid content (HP:0009058)3.18493797
28Increased IgM level (HP:0003496)3.16440101
29Recurrent bacterial skin infections (HP:0005406)3.12570940
30Rough bone trabeculation (HP:0100670)3.10987626
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.09226629
32Abnormality of T cell number (HP:0011839)3.08357570
33Mediastinal lymphadenopathy (HP:0100721)3.03833544
34Oral leukoplakia (HP:0002745)3.03432573
35Abnormality of macrophages (HP:0004311)3.02219439
36Encephalitis (HP:0002383)3.00350985
37Patellar aplasia (HP:0006443)2.98959964
38Recurrent fungal infections (HP:0002841)2.98114008
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96462570
40Meningitis (HP:0001287)2.94646661
41IgM deficiency (HP:0002850)2.92215140
42Hepatocellular necrosis (HP:0001404)2.85354488
43Macrocytic anemia (HP:0001972)2.81739374
44Aplasia/Hypoplasia of the patella (HP:0006498)2.81576226
45Muscle fiber atrophy (HP:0100295)2.81203151
46Chronic otitis media (HP:0000389)2.79486021
47Progressive muscle weakness (HP:0003323)2.79053352
48Trismus (HP:0000211)2.75363827
49Pustule (HP:0200039)2.74702244
50Selective tooth agenesis (HP:0001592)2.73721770
51Increased serum lactate (HP:0002151)2.70020084
52Type 2 muscle fiber atrophy (HP:0003554)2.69203873
53Increased hepatocellular lipid droplets (HP:0006565)2.66380295
54Absent thumb (HP:0009777)2.60516040
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.60283150
56Recurrent bronchitis (HP:0002837)2.59803033
57Hepatic necrosis (HP:0002605)2.55452113
58Autoimmune hemolytic anemia (HP:0001890)2.54336180
59Type I transferrin isoform profile (HP:0003642)2.52545434
60Chronic mucocutaneous candidiasis (HP:0002728)2.50198038
61Recurrent cutaneous fungal infections (HP:0011370)2.50198038
62Panhypogammaglobulinemia (HP:0003139)2.50138747
63Cerebral edema (HP:0002181)2.49394309
64Renal Fanconi syndrome (HP:0001994)2.49389644
65Lipid accumulation in hepatocytes (HP:0006561)2.48880037
66Respiratory difficulties (HP:0002880)2.48724296
67Eosinophilia (HP:0001880)2.46368019
68Severe visual impairment (HP:0001141)2.45547608
69Recurrent viral infections (HP:0004429)2.42746238
70Mitochondrial inheritance (HP:0001427)2.42040966
71Orchitis (HP:0100796)2.41125838
72Pallor (HP:0000980)2.39146793
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38106049
74Pancytopenia (HP:0001876)2.36568746
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36414022
76Abnormality of eosinophils (HP:0001879)2.36299200
77Microvesicular hepatic steatosis (HP:0001414)2.35435029
78Recurrent skin infections (HP:0001581)2.35392021
79Abnormality of glycolysis (HP:0004366)2.35091566
80Increased serum pyruvate (HP:0003542)2.35091566
81Myelodysplasia (HP:0002863)2.34203217
82Increased CSF lactate (HP:0002490)2.31914782
83Retrobulbar optic neuritis (HP:0100654)2.30549144
84Optic neuritis (HP:0100653)2.30549144
85CNS hypomyelination (HP:0003429)2.29740041
86Sparse eyelashes (HP:0000653)2.29352071
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29032928
88IgG deficiency (HP:0004315)2.28939061
89Abnormal number of incisors (HP:0011064)2.28358942
90Leukocytosis (HP:0001974)2.26178526
91Petechiae (HP:0000967)2.25938262
92Acute necrotizing encephalopathy (HP:0006965)2.25828352
93Respiratory failure (HP:0002878)2.25063788
94Increased IgE level (HP:0003212)2.23071204
95Exertional dyspnea (HP:0002875)2.22985449
96Abnormal trabecular bone morphology (HP:0100671)2.22000538
97Bone marrow hypocellularity (HP:0005528)2.21953035
98Tongue fasciculations (HP:0001308)2.21208027
99Gastrointestinal infarctions (HP:0005244)2.20961765
100Ragged-red muscle fibers (HP:0003200)2.20609781
101Secondary amenorrhea (HP:0000869)2.16962373
102Gastrointestinal inflammation (HP:0004386)2.15777273
103Abnormal mitochondria in muscle tissue (HP:0008316)2.15357959
104Inflammation of the large intestine (HP:0002037)2.13764283
105Premature graying of hair (HP:0002216)2.13218118
106Optic nerve coloboma (HP:0000588)2.12372217
107Lymphoma (HP:0002665)2.11009375
108Multiple enchondromatosis (HP:0005701)2.09069259
109Abnormality of T cell physiology (HP:0011840)2.07259323
110Amaurosis fugax (HP:0100576)2.06699947
111Neoplasm of the pancreas (HP:0002894)2.05914256
112Optic disc pallor (HP:0000543)2.05444068
113Autoimmune thrombocytopenia (HP:0001973)2.04932706
114Hypertensive crisis (HP:0100735)2.03128419
115Seborrheic dermatitis (HP:0001051)2.03105202
116Premature ovarian failure (HP:0008209)2.02757407
117Cerebral palsy (HP:0100021)2.02188705
118Muscle fibrillation (HP:0010546)2.02156540
119Agnosia (HP:0010524)2.01489934
120Abnormality of the preputium (HP:0100587)2.00385632
121Hypergammaglobulinemia (HP:0010702)2.00009841
12211 pairs of ribs (HP:0000878)1.97304084
123Recurrent gram-negative bacterial infections (HP:0005420)1.96057131
124Hypoproteinemia (HP:0003075)1.96043249
125Anorexia (HP:0002039)1.95382557
1263-Methylglutaconic aciduria (HP:0003535)1.93184804
127Urticaria (HP:0001025)1.92931303
128Verrucae (HP:0200043)1.92849435
129Papilloma (HP:0012740)1.92849435
130Granulocytopenia (HP:0001913)1.90676403
131Episodic fever (HP:0001954)1.90413336
132Neutropenia (HP:0001875)1.89858188
133Chest pain (HP:0100749)1.89655962
134Combined immunodeficiency (HP:0005387)1.89147429
135Increased serum ferritin (HP:0003281)1.88931714
136Agammaglobulinemia (HP:0004432)1.87562436
137Exercise intolerance (HP:0003546)1.87443838
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87384940
139Emotional lability (HP:0000712)1.87141257
140Lactic acidosis (HP:0003128)1.86427091
141Elevated erythrocyte sedimentation rate (HP:0003565)1.85963315
142Severe combined immunodeficiency (HP:0004430)1.85392404
143Unsteady gait (HP:0002317)1.84881583
144Poikiloderma (HP:0001029)1.84768483
145Meckel diverticulum (HP:0002245)1.84034096
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82793244
147Abnormality of the heme biosynthetic pathway (HP:0010472)1.81350199
148Cleft eyelid (HP:0000625)1.79798417
149Abnormality of the ileum (HP:0001549)1.79010088
150Bronchitis (HP:0012387)1.78540641
151Pulmonary fibrosis (HP:0002206)1.77748289
152Reduced antithrombin III activity (HP:0001976)1.76927744
153B lymphocytopenia (HP:0010976)1.76130353
154Abnormality of B cell number (HP:0010975)1.76130353
155Abnormality of T cells (HP:0002843)1.74074371
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.73178790
157Personality changes (HP:0000751)1.72517644
158Patent foramen ovale (HP:0001655)1.71457493
159Lymphopenia (HP:0001888)1.71140581
160Basal cell carcinoma (HP:0002671)1.69561245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.33320407
2VRK23.41846977
3STK163.17256934
4WEE13.12942389
5EIF2AK12.91819774
6TESK22.88744971
7NME22.62693001
8MAP4K12.52391662
9TSSK62.26789105
10MAP3K122.21136607
11CCNB12.03079840
12MYLK1.92595727
13RIPK41.89330934
14TTK1.79962478
15TLK11.79401288
16TYK21.74021871
17RPS6KB21.73693257
18FES1.72310112
19CDC71.69776837
20NEK11.67899973
21NEK21.67196621
22EPHA21.66864709
23SRPK11.66341510
24TNK21.61125633
25TESK11.60697800
26ITK1.57608929
27DYRK31.57247443
28TXK1.50409135
29ZAP701.50206272
30PIM21.48663236
31VRK11.44308232
32EIF2AK31.43954094
33KDR1.41291510
34ERN11.38912918
35TAOK21.37952752
36ACVR1B1.35254918
37CSK1.32733208
38PLK41.31384354
39RPS6KA41.30389736
40PLK11.29281303
41BLK1.27104746
42ZAK1.26215381
43LCK1.20585981
44CDK71.17226253
45TAOK31.15652572
46CDK191.15504174
47MKNK11.13366850
48PRKCQ1.12754620
49MAPKAPK31.11718998
50PAK41.11679324
51BCKDK1.08593032
52AURKB1.07412671
53JAK31.06614708
54AURKA1.03284399
55EEF2K1.00783959
56HCK1.00457030
57MARK30.98321121
58MAP3K30.97040731
59DAPK30.96141743
60ATR0.96099119
61MKNK20.91846318
62STK100.91579331
63MAP3K110.91079383
64PIM10.90048396
65BTK0.87544854
66STK40.85941713
67DAPK10.83168006
68PAK10.82718870
69CHEK20.82568871
70MAP2K60.82188579
71GRK60.79207789
72CLK10.78054765
73STK240.77472311
74CAMKK20.76450145
75SYK0.75480530
76IRAK30.75086621
77MAP3K80.74872760
78MAP4K20.73978572
79MUSK0.73077456
80RPS6KA50.72477810
81KIT0.72007851
82RPS6KA60.71414718
83TBK10.71402660
84BRSK20.71159555
85FLT30.70465038
86IKBKE0.70150327
87AKT30.67783344
88TEC0.66756609
89PRKCI0.66282701
90SCYL20.65712327
91ADRBK20.65482060
92TGFBR10.65260041
93PDK30.63195623
94PDK40.63195623
95RPS6KC10.63026438
96RPS6KL10.63026438
97PLK30.62415335
98PDK20.61577266
99IRAK40.61537868
100CSF1R0.60993789
101BRSK10.60248446
102IKBKB0.60201524
103CDK40.60180007
104MAP2K30.59065883
105PRPF4B0.58999985
106NME10.58705892
107PASK0.58231950
108ARAF0.57467315
109BRAF0.57347035
110ILK0.57345871
111CSNK2A10.55972229
112LRRK20.53734677
113GRK10.52363130
114TAOK10.51471970
115MAPKAPK20.50848118
116GRK70.50451536
117MST40.49575485
118CSNK2A20.49083742
119CDK80.48345181
120ABL20.48222173
121PINK10.47343675
122NUAK10.46837409
123PIK3CG0.46793326
124CHEK10.46467168
125LYN0.45397340
126FGR0.44057816
127MAP2K20.44005609
128SIK30.43844703
129CAMKK10.42852734
130EPHB10.42521423
131LIMK10.42151663
132OBSCN0.38986775
133MAPK120.38617821
134MAP3K50.37884886
135* CDK20.37642470
136GRK50.36532482
137DYRK20.35595613
138NLK0.35575271
139FYN0.33722509
140MAPK110.33694223
141LMTK20.33378820
142SIK20.33139880
143ADRBK10.32213723
144PDK10.29053562

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30848992
2Ribosome_Homo sapiens_hsa030104.28627572
3RNA polymerase_Homo sapiens_hsa030204.08320963
4Proteasome_Homo sapiens_hsa030503.87243711
5Mismatch repair_Homo sapiens_hsa034303.51598113
6Base excision repair_Homo sapiens_hsa034103.12212345
7Spliceosome_Homo sapiens_hsa030403.04275303
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00535392
9Pyrimidine metabolism_Homo sapiens_hsa002402.67626247
10Nucleotide excision repair_Homo sapiens_hsa034202.67498600
11Graft-versus-host disease_Homo sapiens_hsa053322.63335141
12Homologous recombination_Homo sapiens_hsa034402.61106781
13RNA transport_Homo sapiens_hsa030132.41122263
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07450643
15Cell cycle_Homo sapiens_hsa041101.96457294
16Primary immunodeficiency_Homo sapiens_hsa053401.86418192
17Parkinsons disease_Homo sapiens_hsa050121.79880333
18Oxidative phosphorylation_Homo sapiens_hsa001901.72289240
19Basal transcription factors_Homo sapiens_hsa030221.70322261
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68560882
21Type I diabetes mellitus_Homo sapiens_hsa049401.63949242
22Purine metabolism_Homo sapiens_hsa002301.63624917
23Fanconi anemia pathway_Homo sapiens_hsa034601.56994033
24RNA degradation_Homo sapiens_hsa030181.47194692
25Huntingtons disease_Homo sapiens_hsa050161.42867883
26One carbon pool by folate_Homo sapiens_hsa006701.33953464
27Epstein-Barr virus infection_Homo sapiens_hsa051691.29412814
28Non-homologous end-joining_Homo sapiens_hsa034501.17642581
29p53 signaling pathway_Homo sapiens_hsa041151.16501052
30Antigen processing and presentation_Homo sapiens_hsa046121.13293497
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.13128300
32Pentose phosphate pathway_Homo sapiens_hsa000301.12679690
33mRNA surveillance pathway_Homo sapiens_hsa030151.11892122
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09613018
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.03930215
36Osteoclast differentiation_Homo sapiens_hsa043800.99417470
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99181053
38Rheumatoid arthritis_Homo sapiens_hsa053230.97011238
39Folate biosynthesis_Homo sapiens_hsa007900.96753143
40Vitamin B6 metabolism_Homo sapiens_hsa007500.94681008
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92649629
42Staphylococcus aureus infection_Homo sapiens_hsa051500.92617586
43Alzheimers disease_Homo sapiens_hsa050100.91557911
44Sulfur relay system_Homo sapiens_hsa041220.91464388
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91296915
46Fructose and mannose metabolism_Homo sapiens_hsa000510.89065848
47Protein export_Homo sapiens_hsa030600.77122120
48Regulation of autophagy_Homo sapiens_hsa041400.76346522
49Herpes simplex infection_Homo sapiens_hsa051680.74038134
50Collecting duct acid secretion_Homo sapiens_hsa049660.73685988
51Other glycan degradation_Homo sapiens_hsa005110.72973590
52Tuberculosis_Homo sapiens_hsa051520.72915105
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72351517
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72080504
55Malaria_Homo sapiens_hsa051440.71737072
56Glutathione metabolism_Homo sapiens_hsa004800.69138954
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68283079
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.66462859
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66363686
60Biosynthesis of amino acids_Homo sapiens_hsa012300.65746100
61Shigellosis_Homo sapiens_hsa051310.65693916
62Galactose metabolism_Homo sapiens_hsa000520.64926568
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64587212
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61690728
65Sulfur metabolism_Homo sapiens_hsa009200.59625108
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59300413
67Fatty acid elongation_Homo sapiens_hsa000620.58967484
68Viral carcinogenesis_Homo sapiens_hsa052030.57040070
69Oocyte meiosis_Homo sapiens_hsa041140.56504904
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56259992
71Systemic lupus erythematosus_Homo sapiens_hsa053220.56197737
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55979205
73HTLV-I infection_Homo sapiens_hsa051660.53871096
74Measles_Homo sapiens_hsa051620.53625095
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.52686870
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51445826
77Allograft rejection_Homo sapiens_hsa053300.49919008
78Salmonella infection_Homo sapiens_hsa051320.49717204
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48712855
80Hematopoietic cell lineage_Homo sapiens_hsa046400.47077827
81Cardiac muscle contraction_Homo sapiens_hsa042600.45138899
82Chemokine signaling pathway_Homo sapiens_hsa040620.43866924
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43246585
84Carbon metabolism_Homo sapiens_hsa012000.42999281
85Legionellosis_Homo sapiens_hsa051340.42378038
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.42355556
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41586197
88Asthma_Homo sapiens_hsa053100.41538130
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41534164
90Metabolic pathways_Homo sapiens_hsa011000.40046793
91Apoptosis_Homo sapiens_hsa042100.39605805
92Peroxisome_Homo sapiens_hsa041460.38933071
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38754511
94Phagosome_Homo sapiens_hsa041450.37616630
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37246191
96Arachidonic acid metabolism_Homo sapiens_hsa005900.36332526
97Phototransduction_Homo sapiens_hsa047440.33508604
98Thyroid cancer_Homo sapiens_hsa052160.32797496
99B cell receptor signaling pathway_Homo sapiens_hsa046620.32250742
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32083654
101Toxoplasmosis_Homo sapiens_hsa051450.30986235
102Leishmaniasis_Homo sapiens_hsa051400.29887030
103Endocytosis_Homo sapiens_hsa041440.29878732
104Acute myeloid leukemia_Homo sapiens_hsa052210.28378208
105N-Glycan biosynthesis_Homo sapiens_hsa005100.28174592
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27839972
107Pertussis_Homo sapiens_hsa051330.27768827
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26984899
109TNF signaling pathway_Homo sapiens_hsa046680.26661285
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26657417
111HIF-1 signaling pathway_Homo sapiens_hsa040660.23972061
112T cell receptor signaling pathway_Homo sapiens_hsa046600.23510585
113Notch signaling pathway_Homo sapiens_hsa043300.22364000
114Viral myocarditis_Homo sapiens_hsa054160.22346262
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22296156
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20756901
117Sphingolipid metabolism_Homo sapiens_hsa006000.19957851
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18923900
119Hepatitis B_Homo sapiens_hsa051610.14747478
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13899282
121Autoimmune thyroid disease_Homo sapiens_hsa053200.13845713
122Alcoholism_Homo sapiens_hsa050340.12569357
123Influenza A_Homo sapiens_hsa051640.12316776
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11844618
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11327538
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10419366

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