NOSTRIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.68205596
2L-phenylalanine catabolic process (GO:0006559)4.68205596
3L-phenylalanine metabolic process (GO:0006558)4.63470748
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.63470748
5endothelium development (GO:0003158)4.52727137
6protein-chromophore linkage (GO:0018298)4.50506856
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44599491
8aromatic amino acid family catabolic process (GO:0009074)4.44565223
9high-density lipoprotein particle remodeling (GO:0034375)4.34197465
10lymph vessel development (GO:0001945)4.25892185
11indole-containing compound catabolic process (GO:0042436)4.21591371
12indolalkylamine catabolic process (GO:0046218)4.21591371
13tryptophan catabolic process (GO:0006569)4.21591371
14phospholipid efflux (GO:0033700)4.10082267
15reverse cholesterol transport (GO:0043691)4.05029957
16tryptophan metabolic process (GO:0006568)4.03892796
17bile acid and bile salt transport (GO:0015721)3.92617010
18regulation of protein activation cascade (GO:2000257)3.90622754
19kynurenine metabolic process (GO:0070189)3.81821542
20complement activation, alternative pathway (GO:0006957)3.81061744
21peptidyl-glutamic acid carboxylation (GO:0017187)3.79846400
22protein carboxylation (GO:0018214)3.79846400
23urea metabolic process (GO:0019627)3.78860032
24urea cycle (GO:0000050)3.78860032
25negative regulation of fibrinolysis (GO:0051918)3.78134651
26regulation of cholesterol esterification (GO:0010872)3.76243289
27surfactant homeostasis (GO:0043129)3.75654402
28vascular endothelial growth factor signaling pathway (GO:0038084)3.73557686
29water-soluble vitamin biosynthetic process (GO:0042364)3.71353948
30regulation of complement activation (GO:0030449)3.70684428
31protein-lipid complex remodeling (GO:0034368)3.67969867
32macromolecular complex remodeling (GO:0034367)3.67969867
33plasma lipoprotein particle remodeling (GO:0034369)3.67969867
34cholesterol efflux (GO:0033344)3.65558466
35regulation of fibrinolysis (GO:0051917)3.63568453
36regulation of triglyceride catabolic process (GO:0010896)3.62295328
37homocysteine metabolic process (GO:0050667)3.59045669
38sulfur amino acid catabolic process (GO:0000098)3.58655097
39bile acid biosynthetic process (GO:0006699)3.58535086
40phospholipid homeostasis (GO:0055091)3.57405112
41acylglycerol homeostasis (GO:0055090)3.57318365
42triglyceride homeostasis (GO:0070328)3.57318365
43cellular biogenic amine catabolic process (GO:0042402)3.56431718
44amine catabolic process (GO:0009310)3.56431718
45lipoprotein metabolic process (GO:0042157)3.55491658
46nitrogen cycle metabolic process (GO:0071941)3.54129521
47L-fucose catabolic process (GO:0042355)3.49675667
48fucose catabolic process (GO:0019317)3.49675667
49L-fucose metabolic process (GO:0042354)3.49675667
50estrogen biosynthetic process (GO:0006703)3.47873676
51synapsis (GO:0007129)3.47783658
52positive regulation of vasculogenesis (GO:2001214)3.43972942
53pyrimidine-containing compound transmembrane transport (GO:0072531)3.43178278
54positive regulation of triglyceride lipase activity (GO:0061365)3.37732868
55positive regulation of lipoprotein lipase activity (GO:0051006)3.37732868
56plasma lipoprotein particle clearance (GO:0034381)3.36690688
57short-chain fatty acid metabolic process (GO:0046459)3.27651415
58transcytosis (GO:0045056)3.27051461
59bile acid metabolic process (GO:0008206)3.25279572
60negative regulation of hemostasis (GO:1900047)3.24455545
61negative regulation of blood coagulation (GO:0030195)3.24455545
62intestinal cholesterol absorption (GO:0030299)3.22638316
63cysteine metabolic process (GO:0006534)3.21325040
64cellular response to gonadotropin stimulus (GO:0071371)3.21270675
65plasma lipoprotein particle assembly (GO:0034377)3.21106957
66ubiquinone metabolic process (GO:0006743)3.20056246
67sodium-independent organic anion transport (GO:0043252)3.19552151
68aromatic amino acid family metabolic process (GO:0009072)3.19539199
69negative regulation of metanephros development (GO:0072217)3.19505919
70toxin metabolic process (GO:0009404)3.19340402
71negative regulation of coagulation (GO:0050819)3.18519412
72cholesterol homeostasis (GO:0042632)3.16183980
73glyoxylate metabolic process (GO:0046487)3.14961059
74quinone biosynthetic process (GO:1901663)3.14469440
75sterol homeostasis (GO:0055092)3.13775969
76negative regulation of cholesterol transport (GO:0032375)3.13109556
77negative regulation of sterol transport (GO:0032372)3.13109556
78drug catabolic process (GO:0042737)3.11556999
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11306943
80arginine metabolic process (GO:0006525)3.10331968
81intestinal absorption (GO:0050892)3.10017360
82cellular glucuronidation (GO:0052695)3.09704551
83fibrinolysis (GO:0042730)3.08675478
84vitamin transmembrane transport (GO:0035461)3.06879696
85regulation of bile acid biosynthetic process (GO:0070857)3.05738679
86cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.04065230
87transepithelial transport (GO:0070633)3.03648326
88tyrosine metabolic process (GO:0006570)3.02298457
89peptidyl-tyrosine autophosphorylation (GO:0038083)3.02004366
90L-ascorbic acid metabolic process (GO:0019852)3.01711046
91regulation of vasculogenesis (GO:2001212)3.01690940
92flavonoid metabolic process (GO:0009812)3.00869735
93alpha-linolenic acid metabolic process (GO:0036109)3.00680357
94nephron tubule morphogenesis (GO:0072078)2.99802896
95nephron epithelium morphogenesis (GO:0072088)2.99802896
96plasma lipoprotein particle organization (GO:0071827)2.97986509
97regulation of sequestering of triglyceride (GO:0010889)2.97313541
98indolalkylamine metabolic process (GO:0006586)2.96823698
99ubiquinone biosynthetic process (GO:0006744)2.96749517
100glucuronate metabolic process (GO:0019585)2.96545327
101uronic acid metabolic process (GO:0006063)2.96545327
102regulation of endothelial cell differentiation (GO:0045601)2.93640669
103cellular ketone body metabolic process (GO:0046950)2.93427072
1043-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92875280
105purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92875280
106digestion (GO:0007586)2.89967737
107blood coagulation, intrinsic pathway (GO:0007597)2.84859725
108response to follicle-stimulating hormone (GO:0032354)2.84673872
109chemical homeostasis within a tissue (GO:0048875)2.82696779
110protein-lipid complex assembly (GO:0065005)2.81776543
111low-density lipoprotein particle remodeling (GO:0034374)2.81701587
112alkaloid metabolic process (GO:0009820)2.80197649
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78890324
114behavioral response to nicotine (GO:0035095)2.78719969
115dopamine transport (GO:0015872)2.77582133
116sterol transport (GO:0015918)2.77157594
117cholesterol transport (GO:0030301)2.77157594
118protein-lipid complex subunit organization (GO:0071825)2.76641137
119vitamin A metabolic process (GO:0006776)2.75432441
120protein activation cascade (GO:0072376)2.75299061
121negative regulation of wound healing (GO:0061045)2.75124724
122auditory receptor cell differentiation (GO:0042491)2.71258199
123drug transmembrane transport (GO:0006855)2.70549120
124very-low-density lipoprotein particle assembly (GO:0034379)2.70277904
125sulfation (GO:0051923)2.70133943
126meiotic chromosome segregation (GO:0045132)2.66878795
127benzene-containing compound metabolic process (GO:0042537)2.66382218
128amino-acid betaine metabolic process (GO:0006577)2.65768087
129negative regulation of lipase activity (GO:0060192)2.64154271
130acute-phase response (GO:0006953)2.62835899
131retinol metabolic process (GO:0042572)2.61433139
132ethanol oxidation (GO:0006069)2.60562454
133serotonin metabolic process (GO:0042428)2.58084937
134DNA damage induced protein phosphorylation (GO:0006975)2.57599776
135positive regulation of male gonad development (GO:2000020)2.54171013
136renal tubule morphogenesis (GO:0061333)2.53122577
137regulation of male gonad development (GO:2000018)2.52546806
138estrogen metabolic process (GO:0008210)2.49416620
139bicarbonate transport (GO:0015701)2.47483329
140regulation of guanylate cyclase activity (GO:0031282)2.46751724
141regulation of acrosome reaction (GO:0060046)2.44015811
142dorsal/ventral axis specification (GO:0009950)2.42736794
143androgen biosynthetic process (GO:0006702)2.42679434
144early endosome to late endosome transport (GO:0045022)2.41947106
145centriole replication (GO:0007099)2.41800117
146primary amino compound metabolic process (GO:1901160)2.41722289
147ketone biosynthetic process (GO:0042181)2.40379311
148resolution of meiotic recombination intermediates (GO:0000712)2.39541593
149ketone body metabolic process (GO:1902224)2.39119173
150sensory perception of smell (GO:0007608)2.36579744
151DNA methylation involved in gamete generation (GO:0043046)2.36123954
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.35832130
153heme transport (GO:0015886)2.34763572
154epithelial cell fate commitment (GO:0072148)2.34361305
155regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33626619
156regulation of glucokinase activity (GO:0033131)2.33314758
157regulation of hexokinase activity (GO:1903299)2.33314758
158UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32376891
159regulation of female gonad development (GO:2000194)2.30985910
160glycerol metabolic process (GO:0006071)2.29475639
161embryonic foregut morphogenesis (GO:0048617)2.27915357
162regulation of gonadotropin secretion (GO:0032276)2.27867541
163response to gonadotropin (GO:0034698)2.27677202
164regulation of glomerulus development (GO:0090192)2.27454306
165negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26719471
166neuron fate determination (GO:0048664)2.25596687
167regulation of glucocorticoid secretion (GO:2000849)2.25489583
168positive regulation of guanylate cyclase activity (GO:0031284)2.25011681
169replication fork processing (GO:0031297)2.24962141
170regulation of cGMP biosynthetic process (GO:0030826)2.24456502
171negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.24357741
172adult feeding behavior (GO:0008343)2.24302209
173primary alcohol metabolic process (GO:0034308)2.24162275
174arginine catabolic process (GO:0006527)2.23438626
175negative regulation of macrophage differentiation (GO:0045650)2.23289645
176regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21735120
177biotin metabolic process (GO:0006768)2.21197188
178response to pheromone (GO:0019236)2.20209997
179lung vasculature development (GO:0060426)2.19105715
180regulation of DNA endoreduplication (GO:0032875)2.18768212
181exogenous drug catabolic process (GO:0042738)2.17575060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.81981840
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.86896330
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.55912721
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36884597
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.33428917
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.54523463
7VDR_22108803_ChIP-Seq_LS180_Human3.41695437
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.08433099
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.06160600
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86719226
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85141738
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69670088
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.62426819
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59012249
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.53492481
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43937786
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40590088
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.40509860
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38956547
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31349572
21ZNF274_21170338_ChIP-Seq_K562_Hela2.27010133
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.22175957
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21366621
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19666283
25GBX2_23144817_ChIP-Seq_PC3_Human2.15828485
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09612273
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03865528
28FUS_26573619_Chip-Seq_HEK293_Human2.00064053
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84067490
30SOX2_20726797_ChIP-Seq_SW620_Human1.82955119
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80320896
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77947762
33EWS_26573619_Chip-Seq_HEK293_Human1.77308276
34GATA1_22025678_ChIP-Seq_K562_Human1.77021064
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76806464
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.73812504
37CLOCK_20551151_ChIP-Seq_293T_Human1.71970209
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.71796335
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69189428
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.66441477
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.65755797
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63755792
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.63556359
44TAF15_26573619_Chip-Seq_HEK293_Human1.63182096
45STAT3_23295773_ChIP-Seq_U87_Human1.61182357
46TCF4_23295773_ChIP-Seq_U87_Human1.60584372
47P300_19829295_ChIP-Seq_ESCs_Human1.59273986
48SMAD4_21799915_ChIP-Seq_A2780_Human1.59258514
49ER_23166858_ChIP-Seq_MCF-7_Human1.56962884
50* GATA4_25053715_ChIP-Seq_YYC3_Human1.56148056
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53222253
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52534852
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51532135
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51445187
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51239072
56* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48061098
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.47795876
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46792698
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45862914
60AR_25329375_ChIP-Seq_VCAP_Human1.45151912
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44903664
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44460341
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.43151499
64* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42818621
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39841888
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.37941854
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36325257
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36246444
69PHF8_20622853_ChIP-Seq_HELA_Human1.36038061
70* TCF4_22108803_ChIP-Seq_LS180_Human1.34864695
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34616034
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34616034
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34568372
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.34129263
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34020061
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33989040
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.33948876
78* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33544963
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32462802
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30582343
81SOX2_19829295_ChIP-Seq_ESCs_Human1.29783766
82NANOG_19829295_ChIP-Seq_ESCs_Human1.29783766
83NFYB_21822215_ChIP-Seq_K562_Human1.28912321
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28695871
85* SMAD4_21741376_ChIP-Seq_EPCs_Human1.28295704
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28233159
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27240271
88CBP_20019798_ChIP-Seq_JUKART_Human1.27240271
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26555578
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26406248
91* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26091531
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26046502
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25744305
94* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25723548
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25663899
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23691943
97NFYA_21822215_ChIP-Seq_K562_Human1.22810121
98ETV1_20927104_ChIP-Seq_GIST48_Human1.22045094
99TBL1_22424771_ChIP-Seq_293T_Human1.21719983
100HNFA_21074721_ChIP-Seq_CACO-2_Human1.21353180
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.21059025
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20653955
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20637980
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20608872
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.20246231
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.19945671
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.19660070
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19366589
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19230908
110* SOX2_18555785_Chip-Seq_ESCs_Mouse1.18983515
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16451302
112* STAT3_18555785_Chip-Seq_ESCs_Mouse1.16450912
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16325667
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15476098
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15206909
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15113612
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.15081322
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15081322
119* P53_22387025_ChIP-Seq_ESCs_Mouse1.15063675
120EZH2_22144423_ChIP-Seq_EOC_Human1.15012432
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14470926
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14276806
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13454395
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12590941
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.11864593
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11082067
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.10583096
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.10442654
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10382552
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09966890
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.08171002
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07751515
133CJUN_26792858_Chip-Seq_BT549_Human1.06822626
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05544738
135ESR2_21235772_ChIP-Seq_MCF-7_Human1.03546134
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03354193
137GATA1_19941826_ChIP-Seq_K562_Human1.02561644
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00759194
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00626925
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97445804
141VDR_24787735_ChIP-Seq_THP-1_Human0.97318468
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.97076944
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.96584387
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96464226
145* HNF4A_19822575_ChIP-Seq_HepG2_Human0.96097928
146BP1_19119308_ChIP-ChIP_Hs578T_Human0.94885896
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94535538
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91004738
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91004738
150* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90674065
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.90572448
152* CDX2_22108803_ChIP-Seq_LS180_Human0.88879096
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87984187
154AHR_22903824_ChIP-Seq_MCF-7_Human0.87523054
155* GATA6_25053715_ChIP-Seq_YYC3_Human0.87067333
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.86813331
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86793236
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86086674
159RUNX_20019798_ChIP-Seq_JUKART_Human0.85372746
160IGF1R_20145208_ChIP-Seq_DFB_Human0.83527479
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83511807
162JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82719165
163* GATA2_19941826_ChIP-Seq_K562_Human0.82527512
164BCAT_22108803_ChIP-Seq_LS180_Human0.82180635
165THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81618101
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81083975
167IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79713223
168TP63_23658742_ChIP-Seq_EP156T_Human0.79413289
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.77975417
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.75676688
171GATA3_24758297_ChIP-Seq_MCF-7_Human0.74738474
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74462869
173FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73305188
174BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71731587
175SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70627024
176PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70504140
177GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67860366
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.67394545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.73241854
2MP0002139_abnormal_hepatobiliary_system5.15284892
3MP0002638_abnormal_pupillary_reflex4.58603201
4MP0005085_abnormal_gallbladder_physiolo4.49658508
5MP0002138_abnormal_hepatobiliary_system4.22927588
6MP0005365_abnormal_bile_salt4.20414976
7MP0008995_early_reproductive_senescence3.51809577
8MP0008875_abnormal_xenobiotic_pharmacok3.45579794
9MP0005167_abnormal_blood-brain_barrier3.09251682
10MP0001879_abnormal_lymphatic_vessel3.05088993
11MP0003252_abnormal_bile_duct3.03105422
12MP0003191_abnormal_cellular_cholesterol2.87011848
13MP0010368_abnormal_lymphatic_system2.69877494
14MP0010329_abnormal_lipoprotein_level2.54849010
15MP0002837_dystrophic_cardiac_calcinosis2.48455921
16MP0003724_increased_susceptibility_to2.32958496
17MP0003011_delayed_dark_adaptation2.32760647
18MP0001666_abnormal_nutrient_absorption2.30369802
19MP0004215_abnormal_myocardial_fiber2.18513253
20MP0009840_abnormal_foam_cell2.15918645
21MP0005084_abnormal_gallbladder_morpholo1.99653019
22MP0004043_abnormal_pH_regulation1.98704776
23MP0004019_abnormal_vitamin_homeostasis1.98512154
24MP0002909_abnormal_adrenal_gland1.92953584
25MP0005670_abnormal_white_adipose1.92509524
26MP0002254_reproductive_system_inflammat1.90117798
27MP0009697_abnormal_copulation1.89324068
28MP0003806_abnormal_nucleotide_metabolis1.85032366
29MP0009379_abnormal_foot_pigmentation1.84515710
30MP0005379_endocrine/exocrine_gland_phen1.81789548
31MP0003195_calcinosis1.74478431
32MP0001873_stomach_inflammation1.71155703
33MP0004272_abnormal_basement_membrane1.66959564
34MP0008877_abnormal_DNA_methylation1.66732571
35MP0005551_abnormal_eye_electrophysiolog1.64265957
36MP0001502_abnormal_circadian_rhythm1.64060142
37MP0008775_abnormal_heart_ventricle1.63244270
38MP0005083_abnormal_biliary_tract1.61656479
39MP0005253_abnormal_eye_physiology1.61137874
40MP0000609_abnormal_liver_physiology1.58423681
41MP0004782_abnormal_surfactant_physiolog1.57545646
42MP0005408_hypopigmentation1.55581859
43MP0000372_irregular_coat_pigmentation1.54198840
44MP0001661_extended_life_span1.53682543
45MP0004085_abnormal_heartbeat1.52170275
46MP0005332_abnormal_amino_acid1.50115448
47MP0009764_decreased_sensitivity_to1.49402489
48MP0003718_maternal_effect1.46399009
49MP0010234_abnormal_vibrissa_follicle1.46378870
50MP0009643_abnormal_urine_homeostasis1.46305487
51MP0003300_gastrointestinal_ulcer1.45345811
52MP0003136_yellow_coat_color1.42909197
53MP0005646_abnormal_pituitary_gland1.40486073
54MP0009780_abnormal_chondrocyte_physiolo1.39252028
55MP0002160_abnormal_reproductive_system1.38551545
56MP0001501_abnormal_sleep_pattern1.37722004
57MP0006072_abnormal_retinal_apoptosis1.36794961
58MP0002166_altered_tumor_susceptibility1.35853575
59MP0005535_abnormal_body_temperature1.35713858
60MP0002118_abnormal_lipid_homeostasis1.35688979
61MP0004084_abnormal_cardiac_muscle1.32262685
62MP0003868_abnormal_feces_composition1.32037364
63MP0009785_altered_susceptibility_to1.31332906
64MP0001835_abnormal_antigen_presentation1.30182691
65MP0006276_abnormal_autonomic_nervous1.28579199
66MP0000639_abnormal_adrenal_gland1.25200097
67MP0003646_muscle_fatigue1.22153730
68MP0003137_abnormal_impulse_conducting1.20715271
69MP0004147_increased_porphyrin_level1.19560020
70MP0005319_abnormal_enzyme/_coenzyme1.16390697
71MP0000249_abnormal_blood_vessel1.14179023
72MP0002009_preneoplasia1.12878972
73MP0000631_abnormal_neuroendocrine_gland1.12425646
74MP0006054_spinal_hemorrhage1.12357355
75MP0010386_abnormal_urinary_bladder1.12022687
76MP0004145_abnormal_muscle_electrophysio1.09392658
77MP0004264_abnormal_extraembryonic_tissu1.09105181
78MP0005389_reproductive_system_phenotype1.08567927
79MP0001664_abnormal_digestion1.08396758
80MP0001764_abnormal_homeostasis1.07561622
81MP0001727_abnormal_embryo_implantation1.06725881
82MP0008469_abnormal_protein_level1.06238626
83MP0008872_abnormal_physiological_respon1.06043412
84MP0006036_abnormal_mitochondrial_physio1.05739251
85MP0003705_abnormal_hypodermis_morpholog1.05621644
86MP0002078_abnormal_glucose_homeostasis1.04652133
87MP0003953_abnormal_hormone_level1.03168065
88MP0001485_abnormal_pinna_reflex1.02837031
89MP0002295_abnormal_pulmonary_circulatio1.02701919
90MP0002971_abnormal_brown_adipose1.01269592
91MP0010155_abnormal_intestine_physiology1.01188117
92MP0005448_abnormal_energy_balance1.00684326
93MP0005165_increased_susceptibility_to0.99840668
94MP0002419_abnormal_innate_immunity0.99701646
95MP0003890_abnormal_embryonic-extraembry0.98935102
96MP0003786_premature_aging0.98737263
97MP0003950_abnormal_plasma_membrane0.95967567
98MP0003959_abnormal_lean_body0.93026819
99MP0005636_abnormal_mineral_homeostasis0.92979827
100MP0005164_abnormal_response_to0.92928521
101MP0005385_cardiovascular_system_phenoty0.91957567
102MP0001544_abnormal_cardiovascular_syste0.91957567
103MP0009046_muscle_twitch0.91465387
104MP0000427_abnormal_hair_cycle0.90656713
105MP0003186_abnormal_redox_activity0.90290210
106MP0002136_abnormal_kidney_physiology0.90048348
107MP0008057_abnormal_DNA_replication0.89001576
108MP0003436_decreased_susceptibility_to0.88516962
109MP0004883_abnormal_blood_vessel0.88091895
110MP0000598_abnormal_liver_morphology0.87965985
111MP0002163_abnormal_gland_morphology0.87482412
112MP0002938_white_spotting0.86796958
113MP0005410_abnormal_fertilization0.86015766
114MP0001756_abnormal_urination0.85920681
115MP0005330_cardiomyopathy0.85629436
116MP0005645_abnormal_hypothalamus_physiol0.85258727
117MP0000383_abnormal_hair_follicle0.85210272
118MP0001944_abnormal_pancreas_morphology0.85155922
119MP0002210_abnormal_sex_determination0.84020518
120MP0001929_abnormal_gametogenesis0.83681819
121MP0009763_increased_sensitivity_to0.83604333
122MP0009115_abnormal_fat_cell0.83214830
123MP0005584_abnormal_enzyme/coenzyme_acti0.83183961
124MP0005025_abnormal_response_to0.83108932
125MP0005464_abnormal_platelet_physiology0.82901916
126MP0000767_abnormal_smooth_muscle0.81695333
127MP0005187_abnormal_penis_morphology0.81457144
128MP0005620_abnormal_muscle_contractility0.81281335
129MP0001790_abnormal_immune_system0.80994715
130MP0005387_immune_system_phenotype0.80994715
131MP0000685_abnormal_immune_system0.80813824
132MP0008058_abnormal_DNA_repair0.80789357
133MP0002148_abnormal_hypersensitivity_rea0.80398068
134MP0003828_pulmonary_edema0.78773856
135MP0002928_abnormal_bile_duct0.78759297
136MP0006138_congestive_heart_failure0.78408903
137MP0002006_tumorigenesis0.77908522
138MP0000653_abnormal_sex_gland0.77717726
139MP0003303_peritoneal_inflammation0.77657586
140MP0001845_abnormal_inflammatory_respons0.77050503
141MP0005166_decreased_susceptibility_to0.76790731
142MP0005376_homeostasis/metabolism_phenot0.75349659
143MP0004484_altered_response_of0.74945543
144MP0002332_abnormal_exercise_endurance0.74731668
145MP0005451_abnormal_body_composition0.74438956
146MP0003453_abnormal_keratinocyte_physiol0.74234845
147MP0001663_abnormal_digestive_system0.72020685
148MP0000230_abnormal_systemic_arterial0.71942603
149MP0000013_abnormal_adipose_tissue0.70982880
150MP0003638_abnormal_response/metabolism_0.70244454
151MP0009642_abnormal_blood_homeostasis0.68628810
152MP0002877_abnormal_melanocyte_morpholog0.68457848
153MP0002127_abnormal_cardiovascular_syste0.67583937
154MP0005647_abnormal_sex_gland0.66985887
155MP0005595_abnormal_vascular_smooth0.65983241
156MP0003943_abnormal_hepatobiliary_system0.65823070
157MP0003091_abnormal_cell_migration0.65251215
158MP0001533_abnormal_skeleton_physiology0.65133564
159MP0000613_abnormal_salivary_gland0.65056478
160MP0002452_abnormal_antigen_presenting0.63051672
161MP0004947_skin_inflammation0.62979949
162MP0001765_abnormal_ion_homeostasis0.58957511
163MP0002098_abnormal_vibrissa_morphology0.58689120
164MP0005058_abnormal_lysosome_morphology0.58517670
165MP0002876_abnormal_thyroid_physiology0.56779252
166MP0002822_catalepsy0.54713558

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.77120094
2Deep venous thrombosis (HP:0002625)5.35661876
3Hypoglycemic coma (HP:0001325)5.02671012
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.99756822
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.90467721
6Prolonged partial thromboplastin time (HP:0003645)4.85851392
7Esophageal varix (HP:0002040)4.66907889
8Xanthomatosis (HP:0000991)4.55627984
9Joint hemorrhage (HP:0005261)4.29731446
10Hypoglycemic seizures (HP:0002173)4.25523183
11Complement deficiency (HP:0004431)4.12146968
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10391782
13Hypobetalipoproteinemia (HP:0003563)3.98800678
14Abnormality of the common coagulation pathway (HP:0010990)3.88500442
15Mesangial abnormality (HP:0001966)3.88430570
16Hyperlipoproteinemia (HP:0010980)3.84134804
17Polycythemia (HP:0001901)3.80184796
18Conjugated hyperbilirubinemia (HP:0002908)3.77507986
19Abnormality of the intrinsic pathway (HP:0010989)3.70004663
20Decreased circulating renin level (HP:0003351)3.67800268
21Hypercholesterolemia (HP:0003124)3.66403393
22Hyperinsulinemic hypoglycemia (HP:0000825)3.63679891
23Symptomatic seizures (HP:0011145)3.60434609
24Hyperventilation (HP:0002883)3.58592937
25Myocardial infarction (HP:0001658)3.53457497
26Fat malabsorption (HP:0002630)3.46020416
27Hypolipoproteinemia (HP:0010981)3.44476111
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.37834177
29Hypoalphalipoproteinemia (HP:0003233)3.36114159
30Abnormality of the renal cortex (HP:0011035)3.35986080
31Abnormality of complement system (HP:0005339)3.28883546
32Recurrent gram-negative bacterial infections (HP:0005420)3.18203490
33Hydroxyprolinuria (HP:0003080)3.09680590
34Abnormality of proline metabolism (HP:0010907)3.09680590
35Epidermoid cyst (HP:0200040)3.09462381
36Spontaneous hematomas (HP:0007420)2.95301057
37Gonadal dysgenesis (HP:0000133)2.86289777
38True hermaphroditism (HP:0010459)2.85759010
39Pancreatic islet-cell hyperplasia (HP:0004510)2.84895399
40Systemic lupus erythematosus (HP:0002725)2.81103885
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79732759
42Hyperammonemia (HP:0001987)2.79309822
43Hematochezia (HP:0002573)2.78568769
44Renal cortical cysts (HP:0000803)2.77888072
45Tachypnea (HP:0002789)2.75460151
46Congenital sensorineural hearing impairment (HP:0008527)2.73164438
47Abnormality of the renal medulla (HP:0100957)2.70909402
48Attenuation of retinal blood vessels (HP:0007843)2.67634497
49Skin nodule (HP:0200036)2.65447585
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.64998532
51Absent hand (HP:0004050)2.64805464
52Nephronophthisis (HP:0000090)2.61430150
53Pancreatic cysts (HP:0001737)2.61270538
54Hypothermia (HP:0002045)2.60552466
55Limb hypertonia (HP:0002509)2.59458962
56Autoimmune thrombocytopenia (HP:0001973)2.58748460
57Portal hypertension (HP:0001409)2.50519915
58Hemorrhage of the eye (HP:0011885)2.49457086
59Ketosis (HP:0001946)2.48428958
60Spontaneous abortion (HP:0005268)2.48187162
61Volvulus (HP:0002580)2.47079532
62Confusion (HP:0001289)2.46749437
63Duplicated collecting system (HP:0000081)2.45479276
64Abnormality of purine metabolism (HP:0004352)2.44923995
65Tubular atrophy (HP:0000092)2.44072662
66Hepatocellular carcinoma (HP:0001402)2.43704181
67Abnormality of midbrain morphology (HP:0002418)2.43653973
68Molar tooth sign on MRI (HP:0002419)2.43653973
69Abnormality of vitamin B metabolism (HP:0004340)2.43332583
70Abnormality of methionine metabolism (HP:0010901)2.41956809
71Steatorrhea (HP:0002570)2.40744233
72Male pseudohermaphroditism (HP:0000037)2.39410670
73Abnormal rod and cone electroretinograms (HP:0008323)2.37309253
74Tubulointerstitial nephritis (HP:0001970)2.37192362
75Azoospermia (HP:0000027)2.36409294
76Abnormal biliary tract morphology (HP:0012440)2.35853146
77Cerebral hemorrhage (HP:0001342)2.33349086
78Abnormality of nucleobase metabolism (HP:0010932)2.32983832
79Cerebral palsy (HP:0100021)2.31450819
80Gingival bleeding (HP:0000225)2.31399032
81Focal segmental glomerulosclerosis (HP:0000097)2.31380141
82Glycosuria (HP:0003076)2.31331806
83Abnormality of urine glucose concentration (HP:0011016)2.31331806
84Glomerulonephritis (HP:0000099)2.30528088
85Abnormality of transition element cation homeostasis (HP:0011030)2.29632457
86Abnormality of iron homeostasis (HP:0011031)2.29264717
87Abnormality of endocrine pancreas physiology (HP:0012093)2.28638743
88Abnormality of the pancreatic islet cells (HP:0006476)2.28638743
89Metabolic alkalosis (HP:0200114)2.27303662
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.27029614
91Nausea (HP:0002018)2.26773649
92Abnormality of the hepatic vasculature (HP:0006707)2.26770205
93Pancreatic fibrosis (HP:0100732)2.25644099
94Abnormality of renin-angiotensin system (HP:0000847)2.22857338
95Thrombophlebitis (HP:0004418)2.21743271
96Chromsome breakage (HP:0040012)2.20542038
97Hyperbilirubinemia (HP:0002904)2.20398553
98Acute encephalopathy (HP:0006846)2.20328723
99Abnormality of the renal collecting system (HP:0004742)2.20203413
100Malnutrition (HP:0004395)2.19880873
101Hyperglycemia (HP:0003074)2.19493876
102Ketoacidosis (HP:0001993)2.18727843
103Ileus (HP:0002595)2.18473376
104Proximal tubulopathy (HP:0000114)2.17284970
105Vascular calcification (HP:0004934)2.16901509
106Pigmentary retinal degeneration (HP:0001146)2.16549043
107Amyloidosis (HP:0011034)2.14802396
108Congenital stationary night blindness (HP:0007642)2.14448741
109Abnormality of the fovea (HP:0000493)2.14430813
110Abnormality of vitamin metabolism (HP:0100508)2.14279915
111Nephritis (HP:0000123)2.12347626
112Menorrhagia (HP:0000132)2.12237186
113Pustule (HP:0200039)2.11972781
114Abnormality of macular pigmentation (HP:0008002)2.11281199
115Hyperglycinuria (HP:0003108)2.09517846
116Pancreatitis (HP:0001733)2.09516187
117Abnormality of pyrimidine metabolism (HP:0004353)2.09103507
118Glomerulosclerosis (HP:0000096)2.07892704
119Mitral stenosis (HP:0001718)2.07434968
120Diastasis recti (HP:0001540)2.06276383
121Abnormality of fatty-acid metabolism (HP:0004359)2.05384758
122Joint swelling (HP:0001386)2.05326953
123Abnormality of chromosome stability (HP:0003220)2.05277043
124Eczematoid dermatitis (HP:0000976)2.04513696
125Hyperaldosteronism (HP:0000859)2.04420778
126Conjunctival telangiectasia (HP:0000524)2.03837414
127Pulmonary embolism (HP:0002204)2.03715803
128Aplasia/Hypoplasia of the uvula (HP:0010293)2.02961655
129Limb dystonia (HP:0002451)2.02804489
130Syncope (HP:0001279)2.01499990
131Hepatic necrosis (HP:0002605)2.00091503
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99548940
133Potter facies (HP:0002009)1.99345528
134Facial shape deformation (HP:0011334)1.99345528
135Nonimmune hydrops fetalis (HP:0001790)1.98532598
136Tetraparesis (HP:0002273)1.95533108
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.95484778
138Scotoma (HP:0000575)1.95361508
139Vacuolated lymphocytes (HP:0001922)1.95360361
140Clubbing of toes (HP:0100760)1.94937070
141Large for gestational age (HP:0001520)1.94179095
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.93655901
143Hypoplasia of the fovea (HP:0007750)1.93655901
144Right ventricular cardiomyopathy (HP:0011663)1.93637312
145Chronic hepatic failure (HP:0100626)1.92556583
146Stroke (HP:0001297)1.91212760
147Abnormality of serine family amino acid metabolism (HP:0010894)1.90519657
148Abnormality of glycine metabolism (HP:0010895)1.90519657
149Renal salt wasting (HP:0000127)1.89761219
150Congenital, generalized hypertrichosis (HP:0004540)1.88945790
151Cardiovascular calcification (HP:0011915)1.88162130
152Periodontitis (HP:0000704)1.87404572
153Pendular nystagmus (HP:0012043)1.87097259
154Acute necrotizing encephalopathy (HP:0006965)1.86239412
155Abnormality of the duodenum (HP:0002246)1.85312069
156Recurrent abscess formation (HP:0002722)1.84645914
157Intestinal atresia (HP:0011100)1.83976474
158Reduced antithrombin III activity (HP:0001976)1.82470686
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82271610
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.81865716
161Bony spicule pigmentary retinopathy (HP:0007737)1.81800305
162Prolonged QT interval (HP:0001657)1.81763173
163Abnormal sex determination (HP:0012244)1.80783925
164Sex reversal (HP:0012245)1.80783925
165Fair hair (HP:0002286)1.80715756
166Tubulointerstitial abnormality (HP:0001969)1.79962826
167CNS demyelination (HP:0007305)1.79564660
168Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77715369
169Dicarboxylic aciduria (HP:0003215)1.77715369
170Stenosis of the external auditory canal (HP:0000402)1.77546574
171Abnormal pupillary function (HP:0007686)1.76679498
172Abdominal distention (HP:0003270)1.76427359
173Secondary amenorrhea (HP:0000869)1.76404714
174Delayed CNS myelination (HP:0002188)1.76010553
175Increased CSF lactate (HP:0002490)1.75978941
176Colitis (HP:0002583)1.75415474
177Alkalosis (HP:0001948)1.75187499
178Lethargy (HP:0001254)1.73689281
179Abnormality of the ileum (HP:0001549)1.73289040
180Bile duct proliferation (HP:0001408)1.72892944
181Abnormal biliary tract physiology (HP:0012439)1.72892944
182Meckel diverticulum (HP:0002245)1.71718533
183Enlarged kidneys (HP:0000105)1.71416987
184Polydipsia (HP:0001959)1.69096997
185Abnormal drinking behavior (HP:0030082)1.69096997
186Stage 5 chronic kidney disease (HP:0003774)1.68611705
187Hyperalaninemia (HP:0003348)1.68273124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.19741729
2KDR5.14312628
3FRK3.31701371
4INSRR3.29145383
5TAOK33.11420435
6PIK3CG3.08645038
7MAP3K142.95985726
8WEE12.82870292
9PNCK2.63544790
10STK392.41306820
11MST1R2.39199401
12BRSK22.29398309
13TYK22.19620659
14RIPK12.16799543
15NTRK32.02049533
16MST42.01619127
17FGFR41.98887991
18GRK11.94296551
19IRAK31.91765870
20WNK41.85244924
21PTK61.79058017
22NME11.71795151
23AKT31.70741239
24MAP2K21.69228719
25TGFBR21.68990570
26NUAK11.68777922
27TBK11.66784547
28OXSR11.65225288
29PLK41.62772361
30PINK11.59604162
31CCNB11.57987062
32NLK1.57302870
33PIK3CA1.56462258
34MAP4K21.50352376
35PRKG21.48511148
36MAPK151.45193140
37PRKAA21.43117619
38ADRBK21.42246879
39MAP3K21.38811299
40NEK91.38324900
41ERN11.38244468
42PAK31.37685422
43TNIK1.35222787
44MYLK1.33820913
45WNK31.32301974
46CSNK1G11.32203649
47TTK1.31079805
48MKNK21.29673100
49EIF2AK31.27616285
50EPHB21.27161953
51LATS11.27114158
52IKBKE1.24395391
53BCKDK1.21604379
54PTK2B1.16805766
55JAK11.15700826
56IRAK41.11969656
57EPHB11.11675640
58MAP3K41.10827946
59CSK1.09674309
60ZAK1.09075485
61IKBKB1.07444697
62CSNK1G31.06498158
63MAPK131.06199524
64TGFBR11.00751345
65EPHA31.00446140
66PHKG10.99188528
67PHKG20.99188528
68TEC0.97010401
69TSSK60.96259509
70MET0.95342554
71CSNK1G20.94151326
72ERBB40.94005571
73MAPKAPK30.92368756
74JAK30.87771350
75JAK20.85857506
76MAP3K130.85166304
77EPHA20.85109620
78MAP3K30.83234516
79MAP2K10.80000259
80NEK20.79879420
81CHUK0.77279835
82SGK20.76490426
83MAPK110.75737980
84MAPKAPK50.75461393
85ABL20.74160838
86GSK3A0.72837341
87IRAK10.71890002
88ERBB30.71025350
89BCR0.70861695
90ITK0.70524434
91KIT0.69550535
92EIF2AK10.68653727
93STK38L0.68260375
94OBSCN0.67609620
95MUSK0.63401007
96BMPR1B0.63168363
97PRKCQ0.62916753
98FGFR30.62554025
99IGF1R0.61649512
100MAP2K30.60993419
101FER0.60603211
102CAMK1G0.60407816
103DMPK0.60242819
104PTK20.59135952
105PRKG10.58327042
106PLK30.57720136
107FLT30.56143807
108ABL10.55658192
109CASK0.53138101
110ADRBK10.52211874
111MAPK120.51948770
112PRKAA10.50893950
113MKNK10.50664954
114PRKCE0.49694420
115EGFR0.48846231
116STK30.47989738
117KSR20.47795307
118PLK10.47067702
119CSNK1E0.45565801
120PDK20.45028134
121FGR0.44236943
122NEK10.43835184
123EIF2AK20.43499174
124BMPR20.42683961
125ATM0.41765612
126ACVR1B0.41649865
127ROCK10.41103944
128FGFR20.41001367
129CAMK1D0.40736809
130PRKACA0.40717810
131CSNK1A10.39302551
132GRK60.38531440
133SIK10.38470063
134PRKCG0.38349722
135TRPM70.38218237
136PBK0.37756230
137SGK10.37654739
138MAP3K70.36924328
139LMTK20.36824789
140BRSK10.35615434
141MAPK70.35029916
142PLK20.34553907
143MAP3K120.34084475
144PAK40.33563124
145STK100.32808884
146MAP3K10.32505192
147TRIM280.30565567
148CAMK2D0.30496015
149AKT20.30374786
150INSR0.29772062
151PDPK10.29628528
152PRKACB0.29389746
153SRC0.28661956
154PRKACG0.27894010
155DYRK1B0.27849487
156PDGFRA0.27530411
157LYN0.27488056
158PRKCD0.27019658
159MARK30.25985182
160MAPKAPK20.25160783
161MAP2K60.23959059
162RET0.23854987

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.80651602
2Nitrogen metabolism_Homo sapiens_hsa009103.13867389
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05268197
4Complement and coagulation cascades_Homo sapiens_hsa046103.04968623
5Arginine biosynthesis_Homo sapiens_hsa002202.99854931
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86425818
7Tryptophan metabolism_Homo sapiens_hsa003802.67509014
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26898500
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24458642
10Histidine metabolism_Homo sapiens_hsa003402.22224490
11Bile secretion_Homo sapiens_hsa049762.14907639
12Sulfur metabolism_Homo sapiens_hsa009202.10115179
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.09410231
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.08639143
15Staphylococcus aureus infection_Homo sapiens_hsa051502.08390930
16Vitamin digestion and absorption_Homo sapiens_hsa049772.03212036
17Fatty acid degradation_Homo sapiens_hsa000711.95410045
18Caffeine metabolism_Homo sapiens_hsa002321.90788137
19Fat digestion and absorption_Homo sapiens_hsa049751.85005487
20PPAR signaling pathway_Homo sapiens_hsa033201.81494834
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72241930
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.69834762
23Chemical carcinogenesis_Homo sapiens_hsa052041.68435949
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66921314
25beta-Alanine metabolism_Homo sapiens_hsa004101.62950155
26Peroxisome_Homo sapiens_hsa041461.60637887
27ABC transporters_Homo sapiens_hsa020101.60293161
28Phenylalanine metabolism_Homo sapiens_hsa003601.60267894
29Retinol metabolism_Homo sapiens_hsa008301.53303316
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48680154
31Starch and sucrose metabolism_Homo sapiens_hsa005001.46307731
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46114944
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45783368
34Circadian rhythm_Homo sapiens_hsa047101.40745554
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39962347
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.28965838
37Folate biosynthesis_Homo sapiens_hsa007901.26839226
38Ether lipid metabolism_Homo sapiens_hsa005651.21933600
39Fanconi anemia pathway_Homo sapiens_hsa034601.21424226
40Tyrosine metabolism_Homo sapiens_hsa003501.21268615
41Butanoate metabolism_Homo sapiens_hsa006501.20489480
42Propanoate metabolism_Homo sapiens_hsa006401.15110471
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08961236
44Steroid biosynthesis_Homo sapiens_hsa001001.06320233
45One carbon pool by folate_Homo sapiens_hsa006701.03481322
46Pancreatic secretion_Homo sapiens_hsa049721.01732683
47Arginine and proline metabolism_Homo sapiens_hsa003301.01366764
48Mineral absorption_Homo sapiens_hsa049781.00928080
49Protein export_Homo sapiens_hsa030601.00785742
50Homologous recombination_Homo sapiens_hsa034401.00383212
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00330355
52Fatty acid metabolism_Homo sapiens_hsa012120.99689088
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.97096848
54Selenocompound metabolism_Homo sapiens_hsa004500.96173637
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95899383
56Insulin secretion_Homo sapiens_hsa049110.95499540
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95270909
58Fatty acid biosynthesis_Homo sapiens_hsa000610.93697705
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89856624
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89686614
61Basal transcription factors_Homo sapiens_hsa030220.86901688
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84739578
63Phototransduction_Homo sapiens_hsa047440.83194852
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79178847
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78210009
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77551579
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.76860580
68Olfactory transduction_Homo sapiens_hsa047400.73000092
69Oxidative phosphorylation_Homo sapiens_hsa001900.71475487
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.70981499
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70966697
72Renin-angiotensin system_Homo sapiens_hsa046140.68825939
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68009585
74Non-homologous end-joining_Homo sapiens_hsa034500.67350628
75Arachidonic acid metabolism_Homo sapiens_hsa005900.63983787
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63811764
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.63807565
78Adherens junction_Homo sapiens_hsa045200.63516659
79Pertussis_Homo sapiens_hsa051330.61724069
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60524499
81Cocaine addiction_Homo sapiens_hsa050300.60285028
82Linoleic acid metabolism_Homo sapiens_hsa005910.56129021
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55547751
84Cardiac muscle contraction_Homo sapiens_hsa042600.55217971
85Parkinsons disease_Homo sapiens_hsa050120.55061855
86Amphetamine addiction_Homo sapiens_hsa050310.54723412
87African trypanosomiasis_Homo sapiens_hsa051430.54415866
88TNF signaling pathway_Homo sapiens_hsa046680.53387568
89Serotonergic synapse_Homo sapiens_hsa047260.53382240
90Glycerolipid metabolism_Homo sapiens_hsa005610.52956969
91Galactose metabolism_Homo sapiens_hsa000520.51169000
92Fatty acid elongation_Homo sapiens_hsa000620.50514019
93Hepatitis C_Homo sapiens_hsa051600.49316339
94Thyroid hormone synthesis_Homo sapiens_hsa049180.49004967
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.49004461
96Renin secretion_Homo sapiens_hsa049240.47254496
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46872589
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46740927
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.45921079
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45809718
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44507366
102Ovarian steroidogenesis_Homo sapiens_hsa049130.41899468
103TGF-beta signaling pathway_Homo sapiens_hsa043500.41423062
104Circadian entrainment_Homo sapiens_hsa047130.40618732
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40532424
106Insulin resistance_Homo sapiens_hsa049310.40530211
107Tight junction_Homo sapiens_hsa045300.40504932
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39970789
109Lysine degradation_Homo sapiens_hsa003100.39733624
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39691534
111Leishmaniasis_Homo sapiens_hsa051400.39326022
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39266268
113Sulfur relay system_Homo sapiens_hsa041220.38899913
114Glutathione metabolism_Homo sapiens_hsa004800.38136596
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37996372
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37167906
117Toxoplasmosis_Homo sapiens_hsa051450.36943901
118Prion diseases_Homo sapiens_hsa050200.36771152
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35319916
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33193566
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.32744342
122Pyruvate metabolism_Homo sapiens_hsa006200.30128713
123Sphingolipid metabolism_Homo sapiens_hsa006000.29428612
124Apoptosis_Homo sapiens_hsa042100.29028447
125Dorso-ventral axis formation_Homo sapiens_hsa043200.26756801
126Graft-versus-host disease_Homo sapiens_hsa053320.25837318
127Osteoclast differentiation_Homo sapiens_hsa043800.25446641
128Fructose and mannose metabolism_Homo sapiens_hsa000510.23118706
129Rheumatoid arthritis_Homo sapiens_hsa053230.22448645
130Metabolic pathways_Homo sapiens_hsa011000.17866832
131Allograft rejection_Homo sapiens_hsa053300.17409101
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.17332184
133Amoebiasis_Homo sapiens_hsa051460.16182765
134Protein digestion and absorption_Homo sapiens_hsa049740.15316818
135Malaria_Homo sapiens_hsa051440.15269435
136Lysosome_Homo sapiens_hsa041420.14202829
137Influenza A_Homo sapiens_hsa051640.14098845
138HIF-1 signaling pathway_Homo sapiens_hsa040660.13242250
139Focal adhesion_Homo sapiens_hsa045100.12621787

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