NOTCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95878324
2modulation by symbiont of host defense response (GO:0052031)4.80091292
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.80091292
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.80091292
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.80091292
6modulation by symbiont of host immune response (GO:0052553)4.80091292
7positive regulation by symbiont of host defense response (GO:0052509)4.80091292
8positive regulation of interferon-alpha production (GO:0032727)4.21061028
9antigen processing and presentation of endogenous antigen (GO:0019883)4.14204920
10regulation of interferon-beta biosynthetic process (GO:0045357)4.08320478
11positive regulation of gamma-delta T cell activation (GO:0046645)4.05301696
12regulation of interferon-alpha production (GO:0032647)4.01468409
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95320302
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95320302
15response to muramyl dipeptide (GO:0032495)3.78847110
16response to peptidoglycan (GO:0032494)3.52683127
17macrophage activation involved in immune response (GO:0002281)3.52122542
18neutrophil activation involved in immune response (GO:0002283)3.44200938
19protein localization to endosome (GO:0036010)3.25876580
20cell adhesion mediated by integrin (GO:0033627)3.24200066
21immunoglobulin mediated immune response (GO:0016064)3.24076200
22regulation of B cell receptor signaling pathway (GO:0050855)3.23720057
23hypotonic response (GO:0006971)3.23611226
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23420188
25response to host immune response (GO:0052572)3.23420188
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.22780494
27skin morphogenesis (GO:0043589)3.22343794
28response to host (GO:0075136)3.19546771
29response to host defenses (GO:0052200)3.19546771
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19546771
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17323664
32response to interferon-alpha (GO:0035455)3.08630492
33I-kappaB phosphorylation (GO:0007252)3.08623812
34response to type I interferon (GO:0034340)3.05868486
35positive regulation of natural killer cell differentiation (GO:0032825)3.01813033
36type I interferon signaling pathway (GO:0060337)3.01469130
37cellular response to type I interferon (GO:0071357)3.01469130
38negative regulation of granulocyte differentiation (GO:0030853)2.98549924
39detection of external biotic stimulus (GO:0098581)2.97345650
40apoptotic cell clearance (GO:0043277)2.97023205
41positive regulation of interferon-beta production (GO:0032728)2.96634488
42negative regulation of fatty acid transport (GO:2000192)2.96136176
43cell-substrate junction assembly (GO:0007044)2.95543453
44positive regulation of cellular amide metabolic process (GO:0034250)2.93730715
45detection of other organism (GO:0098543)2.91439954
46hemidesmosome assembly (GO:0031581)2.89534725
47positive regulation of antigen processing and presentation (GO:0002579)2.89028471
48epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88835750
49neutrophil activation (GO:0042119)2.88070222
50interferon-gamma-mediated signaling pathway (GO:0060333)2.87579717
51microglial cell activation (GO:0001774)2.87371859
52regulation of gamma-delta T cell activation (GO:0046643)2.82040116
53positive regulation of B cell differentiation (GO:0045579)2.81730919
54basement membrane organization (GO:0071711)2.81330771
55positive regulation of receptor recycling (GO:0001921)2.80869436
56pinocytosis (GO:0006907)2.79019033
57leukocyte aggregation (GO:0070486)2.78289959
58granulocyte activation (GO:0036230)2.77989131
59regulation of B cell differentiation (GO:0045577)2.75537350
60negative regulation of interleukin-12 production (GO:0032695)2.75209324
61positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75098905
62detection of biotic stimulus (GO:0009595)2.72791090
63tolerance induction (GO:0002507)2.72403850
64embryonic process involved in female pregnancy (GO:0060136)2.71696500
65endodermal cell differentiation (GO:0035987)2.70814459
66NIK/NF-kappaB signaling (GO:0038061)2.66224557
67cortical actin cytoskeleton organization (GO:0030866)2.65024256
68regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64362837
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.63957893
70cellular extravasation (GO:0045123)2.62022788
71regulation of macrophage cytokine production (GO:0010935)2.61966812
72detection of molecule of bacterial origin (GO:0032490)2.61853977
73germinal center formation (GO:0002467)2.61609865
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61097663
75production of molecular mediator involved in inflammatory response (GO:0002532)2.61071785
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60331184
77regulation of gamma-delta T cell differentiation (GO:0045586)2.60311277
78macrophage activation (GO:0042116)2.60137061
79negative regulation of cell killing (GO:0031342)2.59875848
80negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59875848
81regulation of integrin activation (GO:0033623)2.58940067
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57111504
83defense response to protozoan (GO:0042832)2.56779623
84collagen fibril organization (GO:0030199)2.54574644
85cellular response to interferon-alpha (GO:0035457)2.54079900
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53739514
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53389795
88respiratory burst (GO:0045730)2.52212598
89membrane protein ectodomain proteolysis (GO:0006509)2.52090655
90regulation of antigen processing and presentation (GO:0002577)2.52025197
91chondroitin sulfate biosynthetic process (GO:0030206)2.51595491
92barbed-end actin filament capping (GO:0051016)2.51177584
93B cell receptor signaling pathway (GO:0050853)2.49595417
94B cell mediated immunity (GO:0019724)2.49566536
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48266343
96natural killer cell mediated immunity (GO:0002228)2.46952252
97natural killer cell mediated cytotoxicity (GO:0042267)2.46952252
98cellular response to exogenous dsRNA (GO:0071360)2.46044725
99stress fiber assembly (GO:0043149)2.45357392
100iron ion import (GO:0097286)2.45054883
101negative regulation of erythrocyte differentiation (GO:0045647)2.43872413
102myeloid cell activation involved in immune response (GO:0002275)2.43281791
103detection of bacterium (GO:0016045)2.42735072
104natural killer cell differentiation (GO:0001779)2.42701891
105negative regulation of B cell proliferation (GO:0030889)2.42670511
106adherens junction assembly (GO:0034333)2.42494475
107positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.42286345
108positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41483703
109positive thymic T cell selection (GO:0045059)2.40918414
110myeloid dendritic cell activation (GO:0001773)2.39806753
111positive regulation of chemokine biosynthetic process (GO:0045080)2.39804478
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.39586241
113negative thymic T cell selection (GO:0045060)2.38280154
114response to protozoan (GO:0001562)2.37793086
115cortical cytoskeleton organization (GO:0030865)2.37113272
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.36418509
117leukocyte cell-cell adhesion (GO:0007159)2.36362504
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.34854314
119substrate-dependent cell migration (GO:0006929)2.34832837
120antigen processing and presentation via MHC class Ib (GO:0002475)2.33963119
121negative regulation of phagocytosis (GO:0050765)2.33366199
122negative regulation of viral genome replication (GO:0045071)2.32805439
123regulation of T-helper 2 cell differentiation (GO:0045628)2.32758159
124regulation of mast cell degranulation (GO:0043304)2.32023158
125focal adhesion assembly (GO:0048041)2.31824898
126cell-substrate adherens junction assembly (GO:0007045)2.31824898
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.31436236
128membrane raft organization (GO:0031579)2.31319137
129positive regulation of interleukin-12 production (GO:0032735)2.31256831
130negative regulation of anoikis (GO:2000811)2.31185891
131positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.30879787
132collagen metabolic process (GO:0032963)2.30361004
133regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30235440
134cellular response to zinc ion (GO:0071294)2.30067359
135response to laminar fluid shear stress (GO:0034616)2.28851484
136T cell migration (GO:0072678)2.27699513
137cellular response to interferon-gamma (GO:0071346)2.27687536
138regulation of interleukin-12 production (GO:0032655)2.27513648
139response to fluid shear stress (GO:0034405)2.26939045
140wound healing, spreading of cells (GO:0044319)2.25694823
141positive regulation of mast cell activation (GO:0033005)2.25634197
142myeloid dendritic cell differentiation (GO:0043011)2.25441615
143positive regulation of extracellular matrix organization (GO:1903055)2.25307704
144regulation of mast cell activation (GO:0033003)2.24861596
145wound healing, spreading of epidermal cells (GO:0035313)2.24817992
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.24630081
147platelet-derived growth factor receptor signaling pathway (GO:0048008)2.21875526
148chondrocyte development (GO:0002063)2.20780755
149pathway-restricted SMAD protein phosphorylation (GO:0060389)2.18841834
150COPI coating of Golgi vesicle (GO:0048205)2.18069009
151Golgi transport vesicle coating (GO:0048200)2.18069009
152collagen catabolic process (GO:0030574)2.18013478
153positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.17462314
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.16018559
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.15411382
156regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.15130984
157mannose metabolic process (GO:0006013)2.14700094
158positive regulation of macrophage cytokine production (GO:0060907)2.13694800
159regulation of leukocyte degranulation (GO:0043300)2.13313572
160nuclear pore complex assembly (GO:0051292)2.13027267
161regulation of necroptotic process (GO:0060544)2.12729234
162cellular response to ethanol (GO:0071361)2.10981195
163mesodermal cell differentiation (GO:0048333)2.10487830
164integrin-mediated signaling pathway (GO:0007229)2.10467602
165epithelial cell-cell adhesion (GO:0090136)2.10208809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.52872998
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.63100811
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.44058217
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.10164684
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62124686
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42986645
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.41263239
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.40969786
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40868971
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24679628
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23116153
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01570356
13E2F7_22180533_ChIP-Seq_HELA_Human2.86209124
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81687214
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73695776
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67330916
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.65909756
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57145083
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46372933
20SCL_19346495_ChIP-Seq_HPC-7_Human2.39048990
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30713611
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12363861
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08908505
24VDR_21846776_ChIP-Seq_THP-1_Human2.06005443
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05056059
26RUNX_20019798_ChIP-Seq_JUKART_Human2.03830939
27MYC_22102868_ChIP-Seq_BL_Human1.98959598
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97238719
29VDR_24763502_ChIP-Seq_THP-1_Human1.94618658
30MAF_26560356_Chip-Seq_TH1_Human1.94020381
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.93064084
32MYB_26560356_Chip-Seq_TH2_Human1.87821507
33* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82851450
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76936811
35* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76815819
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.75775259
37SPI1_23547873_ChIP-Seq_NB4_Human1.72235365
38* MYB_26560356_Chip-Seq_TH1_Human1.71913695
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65910155
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.64333104
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60973044
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.59152864
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59138129
44* SPI1_23127762_ChIP-Seq_K562_Human1.57345540
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55876489
46PU_27001747_Chip-Seq_BMDM_Mouse1.54680448
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.54586223
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52869775
49VDR_24787735_ChIP-Seq_THP-1_Human1.52647344
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52489369
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50912612
52GATA1_22025678_ChIP-Seq_K562_Human1.49812747
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49527369
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.45444320
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44166771
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42584649
57* UTX_26944678_Chip-Seq_JUKART_Human1.40908935
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39749295
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39402422
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39254247
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39220945
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36355013
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33701257
64KDM2B_26808549_Chip-Seq_K562_Human1.32787022
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32421483
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32121185
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31549629
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.31281705
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31072967
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29868513
71* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29356127
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.29155331
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.29155331
74* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26597600
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25741744
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25741744
77* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25522361
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24770878
79CLOCK_20551151_ChIP-Seq_293T_Human1.23501089
80KDM2B_26808549_Chip-Seq_DND41_Human1.22080752
81RACK7_27058665_Chip-Seq_MCF-7_Human1.21408652
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19433988
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18371362
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17710300
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16787122
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16296812
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16182975
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15822046
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.15698843
90TP53_16413492_ChIP-PET_HCT116_Human1.13169981
91* WT1_19549856_ChIP-ChIP_CCG9911_Human1.13002403
92* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12577983
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10913497
94AHR_22903824_ChIP-Seq_MCF-7_Human1.10784200
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10131683
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.09967871
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09709204
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09218874
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07672663
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06286397
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06222733
102GATA3_27048872_Chip-Seq_THYMUS_Human1.05047895
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05022409
104* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04529368
105* RUNX1_27514584_Chip-Seq_MCF-7_Human1.03393949
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02962690
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02105000
108* BRD4_25478319_ChIP-Seq_HGPS_Human1.01723472
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.99695996
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.97578136
111* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97286007
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96671986
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96671986
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96227738
115* MAF_26560356_Chip-Seq_TH2_Human0.96104906
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95426894
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93229159
118* CJUN_26792858_Chip-Seq_BT549_Human0.92038817
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.89375194
120NCOR1_26117541_ChIP-Seq_K562_Human0.89149752
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84743041
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.84021364
123GATA2_19941826_ChIP-Seq_K562_Human0.83346061
124* UBF1/2_26484160_Chip-Seq_HMECs_Human0.81794944
125GATA3_26560356_Chip-Seq_TH2_Human0.81609514
126* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81465469
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.80877314
128* GATA1_19941827_ChIP-Seq_MEL_Mouse0.80207690
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79294171
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.78980672
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77863337
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77269256
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76467853
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75862520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.58732635
2MP0008438_abnormal_cutaneous_collagen2.88223593
3MP0000569_abnormal_digit_pigmentation2.68419595
4MP0003436_decreased_susceptibility_to2.68014759
5MP0000685_abnormal_immune_system2.54136442
6MP0003303_peritoneal_inflammation2.52274398
7MP0005387_immune_system_phenotype2.49444300
8MP0001790_abnormal_immune_system2.49444300
9MP0002419_abnormal_innate_immunity2.24621339
10MP0001800_abnormal_humoral_immune2.23111198
11MP0002166_altered_tumor_susceptibility2.17222204
12MP0005000_abnormal_immune_tolerance2.16286932
13MP0002452_abnormal_antigen_presenting2.15740459
14MP0003300_gastrointestinal_ulcer2.14921494
15MP0009278_abnormal_bone_marrow2.11848621
16MP0009785_altered_susceptibility_to2.11483571
17MP0002148_abnormal_hypersensitivity_rea2.06224249
18MP0003705_abnormal_hypodermis_morpholog2.01962008
19MP0004272_abnormal_basement_membrane1.99412209
20* MP0005025_abnormal_response_to1.97915284
21MP0005076_abnormal_cell_differentiation1.93781742
22MP0005671_abnormal_response_to1.89598351
23MP0002006_tumorigenesis1.86952303
24MP0002723_abnormal_immune_serum1.85385426
25MP0003724_increased_susceptibility_to1.83172903
26MP0004510_myositis1.81051116
27MP0008260_abnormal_autophagy1.80603402
28MP0003279_aneurysm1.75462270
29* MP0001819_abnormal_immune_cell1.75085956
30* MP0002420_abnormal_adaptive_immunity1.74476043
31MP0003566_abnormal_cell_adhesion1.73161041
32MP0005464_abnormal_platelet_physiology1.71917895
33MP0006082_CNS_inflammation1.69725125
34MP0005451_abnormal_body_composition1.69632644
35MP0004947_skin_inflammation1.67644071
36MP0004808_abnormal_hematopoietic_stem1.66061508
37MP0002396_abnormal_hematopoietic_system1.64169329
38MP0001853_heart_inflammation1.63822040
39MP0001533_abnormal_skeleton_physiology1.62881988
40MP0002405_respiratory_system_inflammati1.61466995
41MP0001958_emphysema1.60749805
42MP0005058_abnormal_lysosome_morphology1.57914582
43MP0005397_hematopoietic_system_phenotyp1.56597186
44MP0001545_abnormal_hematopoietic_system1.56597186
45MP0005275_abnormal_skin_tensile1.55084360
46MP0001849_ear_inflammation1.50419958
47MP0005623_abnormal_meninges_morphology1.45011845
48MP0010352_gastrointestinal_tract_polyps1.44616917
49MP0005023_abnormal_wound_healing1.42258090
50MP0005409_darkened_coat_color1.41956287
51MP0003448_altered_tumor_morphology1.41747634
52* MP0002398_abnormal_bone_marrow1.41199201
53MP0010155_abnormal_intestine_physiology1.39451424
54* MP0000716_abnormal_immune_system1.37515352
55MP0002254_reproductive_system_inflammat1.37151002
56MP0005164_abnormal_response_to1.36241169
57MP0001845_abnormal_inflammatory_respons1.35742050
58MP0003091_abnormal_cell_migration1.34093002
59MP0004858_abnormal_nervous_system1.31280346
60MP0002998_abnormal_bone_remodeling1.29412343
61* MP0000689_abnormal_spleen_morphology1.25919233
62MP0003191_abnormal_cellular_cholesterol1.24337292
63MP0004883_abnormal_blood_vessel1.22641552
64MP0010307_abnormal_tumor_latency1.20587214
65MP0000858_altered_metastatic_potential1.19294881
66MP0002896_abnormal_bone_mineralization1.18829681
67MP0000343_altered_response_to1.17371851
68MP0002722_abnormal_immune_system1.15876290
69* MP0000767_abnormal_smooth_muscle1.15491504
70MP0002933_joint_inflammation1.15420692
71MP0003763_abnormal_thymus_physiology1.14848891
72MP0005390_skeleton_phenotype1.14427874
73MP0010234_abnormal_vibrissa_follicle1.14236288
74MP0003950_abnormal_plasma_membrane1.12735714
75* MP0002429_abnormal_blood_cell1.12266395
76MP0003172_abnormal_lysosome_physiology1.11625989
77MP0001873_stomach_inflammation1.10903960
78MP0006054_spinal_hemorrhage1.10767708
79MP0001915_intracranial_hemorrhage1.10136144
80MP0000733_abnormal_muscle_development1.09737040
81MP0005174_abnormal_tail_pigmentation1.09173170
82MP0005248_abnormal_Harderian_gland1.08808562
83MP0009333_abnormal_splenocyte_physiolog1.08096130
84MP0009764_decreased_sensitivity_to1.05798139
85MP0000465_gastrointestinal_hemorrhage1.04191910
86* MP0008469_abnormal_protein_level1.01602292
87MP0009840_abnormal_foam_cell0.99924909
88MP0002060_abnormal_skin_morphology0.99434697
89MP0003045_fibrosis0.97313919
90MP0003453_abnormal_keratinocyte_physiol0.96263332
91MP0005621_abnormal_cell_physiology0.94344997
92MP0004233_abnormal_muscle_weight0.94273528
93MP0005503_abnormal_tendon_morphology0.92104408
94MP0003828_pulmonary_edema0.91008989
95MP0003690_abnormal_glial_cell0.90385992
96MP0002133_abnormal_respiratory_system0.89827884
97MP0005388_respiratory_system_phenotype0.89827884
98MP0004185_abnormal_adipocyte_glucose0.88894842
99MP0001542_abnormal_bone_strength0.88507653
100MP0002796_impaired_skin_barrier0.87389423
101MP0008004_abnormal_stomach_pH0.87086031
102MP0000428_abnormal_craniofacial_morphol0.86966177
103MP0002168_other_aberrant_phenotype0.83943245
104MP0002877_abnormal_melanocyte_morpholog0.83538977
105MP0009763_increased_sensitivity_to0.82036793
106MP0005257_abnormal_intraocular_pressure0.81887902
107MP0000703_abnormal_thymus_morphology0.81570118
108MP0009053_abnormal_anal_canal0.79510043
109MP0003075_altered_response_to0.78521879
110MP0003941_abnormal_skin_development0.78470787
111* MP0000371_diluted_coat_color0.78421851
112MP0001243_abnormal_dermal_layer0.77747785
113MP0002009_preneoplasia0.77501487
114MP0002138_abnormal_hepatobiliary_system0.76741564
115MP0000490_abnormal_crypts_of0.75842795
116MP0005595_abnormal_vascular_smooth0.74444830
117MP0000604_amyloidosis0.73855773
118MP0003795_abnormal_bone_structure0.73814625
119MP0000534_abnormal_ureter_morphology0.73752748
120MP0001216_abnormal_epidermal_layer0.73453111
121MP0000249_abnormal_blood_vessel0.73249193
122MP0010030_abnormal_orbit_morphology0.72617627
123MP0000383_abnormal_hair_follicle0.72577413
124MP0010368_abnormal_lymphatic_system0.72226486
125MP0001348_abnormal_lacrimal_gland0.71771050
126MP0001851_eye_inflammation0.70195478
127MP0008007_abnormal_cellular_replicative0.68939391
128MP0002108_abnormal_muscle_morphology0.68025899
129MP0005508_abnormal_skeleton_morphology0.65823264
130MP0001879_abnormal_lymphatic_vessel0.62908398
131MP0005166_decreased_susceptibility_to0.61609529
132MP0009384_cardiac_valve_regurgitation0.59677060

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.38028947
2Eczematoid dermatitis (HP:0000976)4.25811226
3Recurrent bacterial skin infections (HP:0005406)4.06299530
4Mediastinal lymphadenopathy (HP:0100721)3.30691323
5Arterial tortuosity (HP:0005116)3.27869895
6Recurrent gram-negative bacterial infections (HP:0005420)3.26419604
7Systemic lupus erythematosus (HP:0002725)3.22918606
8Vascular tortuosity (HP:0004948)3.18706464
9Autoimmune thrombocytopenia (HP:0001973)3.18620084
10Myositis (HP:0100614)3.07297110
11Myocardial infarction (HP:0001658)3.06925742
12Atrophic scars (HP:0001075)2.88906060
13Cellulitis (HP:0100658)2.82258702
14Recurrent fungal infections (HP:0002841)2.80396765
15Hematochezia (HP:0002573)2.78843293
16Elevated erythrocyte sedimentation rate (HP:0003565)2.76830381
17Orchitis (HP:0100796)2.76757289
18Cerebral aneurysm (HP:0004944)2.76574359
19Protrusio acetabuli (HP:0003179)2.74695159
20Gingivitis (HP:0000230)2.71956025
21Recurrent skin infections (HP:0001581)2.67508748
22Recurrent viral infections (HP:0004429)2.66248053
23Peritonitis (HP:0002586)2.64047871
24Shallow orbits (HP:0000586)2.59839918
25Broad face (HP:0000283)2.57291245
26Aortic aneurysm (HP:0004942)2.56709256
27Abnormality of macrophages (HP:0004311)2.55261383
28Abnormality of the fingertips (HP:0001211)2.53262806
29Vasculitis (HP:0002633)2.49262581
30Short 4th metacarpal (HP:0010044)2.47291914
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47291914
32Retrobulbar optic neuritis (HP:0100654)2.44260487
33Optic neuritis (HP:0100653)2.44260487
34Arterial thrombosis (HP:0004420)2.43273926
35Aortic dissection (HP:0002647)2.42341912
36Fragile skin (HP:0001030)2.42120711
37* Periodontitis (HP:0000704)2.41811291
38Glomerulonephritis (HP:0000099)2.39403588
39Ankle contracture (HP:0006466)2.36970788
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.33207326
41Aneurysm (HP:0002617)2.31941197
42Premature rupture of membranes (HP:0001788)2.31925303
43* Osteolytic defects of the hand bones (HP:0009699)2.31789849
44* Osteolytic defects of the phalanges of the hand (HP:0009771)2.31789849
45Increased density of long bones (HP:0006392)2.31051646
46Chronic otitis media (HP:0000389)2.30706626
47Mitral regurgitation (HP:0001653)2.30241238
48Spondylolisthesis (HP:0003302)2.29613864
49Gingival bleeding (HP:0000225)2.28798553
50Genu recurvatum (HP:0002816)2.26515114
51Blue sclerae (HP:0000592)2.25380573
52Thick nail (HP:0001805)2.23405042
53Nephritis (HP:0000123)2.22789257
54Colitis (HP:0002583)2.22614520
55Recurrent cutaneous fungal infections (HP:0011370)2.19957925
56Chronic mucocutaneous candidiasis (HP:0002728)2.19957925
57Mitral valve prolapse (HP:0001634)2.17576815
58Bladder diverticulum (HP:0000015)2.17100453
59Interstitial pulmonary disease (HP:0006530)2.16636098
60Thin bony cortex (HP:0002753)2.15055962
61Osteomyelitis (HP:0002754)2.14838799
62Dilatation of the ascending aorta (HP:0005111)2.14811882
63Increased connective tissue (HP:0009025)2.13950274
64Emphysema (HP:0002097)2.13756460
65Increased cerebral lipofuscin (HP:0011813)2.12471429
66Pustule (HP:0200039)2.12171761
67Obstructive lung disease (HP:0006536)2.11145112
68Chronic obstructive pulmonary disease (HP:0006510)2.11145112
69Pulmonary infiltrates (HP:0002113)2.09805515
70Spontaneous hematomas (HP:0007420)2.09546224
71Meningitis (HP:0001287)2.08595199
72* Wormian bones (HP:0002645)2.08518108
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.08456216
74Abnormality of glycolipid metabolism (HP:0010969)2.08456216
75Abnormality of liposaccharide metabolism (HP:0010968)2.08456216
76Overgrowth (HP:0001548)2.08118661
77Urethral obstruction (HP:0000796)2.07624846
78Soft skin (HP:0000977)2.06083960
79Agammaglobulinemia (HP:0004432)2.02007388
80Flat acetabular roof (HP:0003180)1.99807898
81Cervical subluxation (HP:0003308)1.99155820
82Inflammation of the large intestine (HP:0002037)1.99147584
83Abnormality of the peritoneum (HP:0002585)1.97116352
84* Joint laxity (HP:0001388)1.96927751
85Abnormality of complement system (HP:0005339)1.96113958
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95965283
87Aortic regurgitation (HP:0001659)1.93936146
88Prolonged bleeding time (HP:0003010)1.93803464
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.93704320
90Gastrointestinal inflammation (HP:0004386)1.93227341
91Neonatal short-limb short stature (HP:0008921)1.92098723
92Increased neuronal autofluorescent lipopigment (HP:0002074)1.90631435
93Camptodactyly of toe (HP:0001836)1.88945105
94Disproportionate tall stature (HP:0001519)1.88823054
95Increased variability in muscle fiber diameter (HP:0003557)1.88385725
96Prostate neoplasm (HP:0100787)1.88132535
97Broad metatarsal (HP:0001783)1.88113530
98Leukocytosis (HP:0001974)1.84368646
99IgM deficiency (HP:0002850)1.82339995
100Recurrent bronchitis (HP:0002837)1.82143465
101Amyloidosis (HP:0011034)1.81956698
102Ulnar bowing (HP:0003031)1.81909126
103Gastrointestinal infarctions (HP:0005244)1.79979900
104Abnormality of oral frenula (HP:0000190)1.78971365
105Keratoconjunctivitis sicca (HP:0001097)1.78847130
106Abnormal platelet volume (HP:0011876)1.78762245
107Vacuolated lymphocytes (HP:0001922)1.78502741
108Abnormal ossification of hand bones (HP:0005921)1.77926011
109Abnormality of the 4th metacarpal (HP:0010012)1.77615353
110Hypoplasia of the iris (HP:0007676)1.77426934
111Epistaxis (HP:0000421)1.76936145
112Gastrointestinal stroma tumor (HP:0100723)1.76911594
113Stomatitis (HP:0010280)1.76370789
114Joint contractures involving the joints of the feet (HP:0100492)1.76083782
115Flexion contracture of toe (HP:0005830)1.76083782
116* Vertebral compression fractures (HP:0002953)1.76028111
117Natal tooth (HP:0000695)1.75996921
118Basal ganglia calcification (HP:0002135)1.74821071
119Vertebral arch anomaly (HP:0008438)1.74672588
120Narrow palate (HP:0000189)1.74603155
121* Absent frontal sinuses (HP:0002688)1.74463870
122Subacute progressive viral hepatitis (HP:0006572)1.74198400
123Persistence of primary teeth (HP:0006335)1.73703812
124Wide anterior fontanel (HP:0000260)1.73495682
125Hyperacusis (HP:0010780)1.73116701
126Abnormality of the acetabulum (HP:0003170)1.72715355
127Esophageal varix (HP:0002040)1.72043815
128Bruising susceptibility (HP:0000978)1.71767710
129Alopecia of scalp (HP:0002293)1.71515393
130Viral hepatitis (HP:0006562)1.71506959
131Spinal rigidity (HP:0003306)1.71156580
132IgA deficiency (HP:0002720)1.70861246
133Distal lower limb amyotrophy (HP:0008944)1.70753914
134Recurrent lower respiratory tract infections (HP:0002783)1.70595465
135Dysostosis multiplex (HP:0000943)1.69228481
136Urticaria (HP:0001025)1.68608471
137Thoracolumbar scoliosis (HP:0002944)1.67801130
138Thrombocytosis (HP:0001894)1.67171298
139Hyperextensible skin (HP:0000974)1.66534008
140Increased mean platelet volume (HP:0011877)1.66489869
141Elbow flexion contracture (HP:0002987)1.65283990
142Complement deficiency (HP:0004431)1.65002190
143Tibial bowing (HP:0002982)1.64838992
144Follicular hyperkeratosis (HP:0007502)1.64503132
145Cupped ribs (HP:0000887)1.64157599
146Premature loss of primary teeth (HP:0006323)1.63914540
147Bicuspid aortic valve (HP:0001647)1.63487921
148Deep philtrum (HP:0002002)1.62494120
149Abnormality of skeletal muscle fiber size (HP:0012084)1.62057128
150Mucopolysacchariduria (HP:0008155)1.60836027
151Urinary glycosaminoglycan excretion (HP:0003541)1.60836027
152Cerebral inclusion bodies (HP:0100314)1.60537673
153Loss of speech (HP:0002371)1.59402581
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58588044
155Asymmetry of the thorax (HP:0001555)1.56719144
156Abnormality of dentin (HP:0010299)1.56507939
157Delayed cranial suture closure (HP:0000270)1.56347933
158Relative macrocephaly (HP:0004482)1.56051067
159Ankyloglossia (HP:0010296)1.55670969
160* Spinal cord lesions (HP:0100561)1.54877707
161* Syringomyelia (HP:0003396)1.54877707
162Short clavicles (HP:0000894)1.54567533
163Broad ribs (HP:0000885)1.53079368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.39704038
2MAP4K13.13410097
3PRPF4B2.81740399
4TYK22.77025361
5JAK32.33562931
6TBK12.15350583
7JAK12.14670323
8TTN2.11641339
9CDK122.09190139
10ERN12.07249559
11IRAK32.06421159
12TGFBR22.03243891
13IKBKE2.01890879
14KIT2.00670515
15IRAK41.94904028
16BLK1.91021529
17IKBKB1.90033641
18SIK11.87796154
19CAMK1D1.86792016
20ICK1.84230638
21NEK91.83990304
22STK101.79510950
23CHUK1.78264753
24CSF1R1.72380615
25TRIB31.72307267
26FGFR31.65923453
27MAP3K101.54334910
28FGFR41.50815748
29SMG11.46358779
30ZAP701.42267597
31TXK1.41501463
32CSK1.37479902
33BTK1.36804167
34RPS6KA41.34939836
35EPHB11.34315196
36PIM11.33704255
37MAP2K31.33056939
38RIPK41.31532099
39RIPK11.29119745
40KSR21.28877582
41PTK61.26888156
42MAP3K61.26630681
43EPHA31.25842425
44MAP3K131.24758759
45HCK1.22678472
46BMX1.18773808
47LRRK21.16981585
48MAP3K21.16680024
49CAMK1G1.16262474
50EEF2K1.16143195
51PKN21.16027618
52TRPM71.13198517
53CDK61.11973614
54PTK21.11561375
55MOS1.10082309
56CDC42BPA1.08029112
57LATS11.07900768
58MARK21.07560718
59STK381.06698430
60TEC1.05799028
61MELK1.00250330
62STK31.00210363
63MAPK70.98765007
64AKT30.97699430
65STK40.97111512
66MAP3K10.96544862
67TAOK30.95862377
68CLK10.95193066
69MATK0.94478418
70LATS20.94033390
71PRKD20.93885202
72SIK30.93563921
73BRD40.92546798
74SYK0.90383372
75PAK40.89991644
76RPS6KA20.85942573
77MET0.85709194
78TAOK20.85036232
79LCK0.84833874
80WNK10.83303448
81RET0.82746459
82JAK20.82527046
83LYN0.81620660
84SCYL20.74254115
85TAOK10.73366473
86MARK30.72423806
87NUAK10.70843242
88FLT30.70787530
89ITK0.69375548
90EIF2AK20.69299048
91MKNK10.69273949
92SGK30.68640761
93IRAK10.68467478
94MYLK0.68180808
95MAP3K70.66437573
96KSR10.65731610
97IRAK20.65486781
98PDGFRA0.63853412
99MST1R0.62994093
100PDPK10.62071787
101EPHA20.62049941
102CDK40.61456312
103ERBB30.60185369
104GRK60.59327653
105EPHB20.59254179
106MTOR0.59234650
107CDK90.59119373
108PDGFRB0.58775100
109MKNK20.56906951
110NEK60.56745541
111RPS6KA60.55188965
112ABL10.54982588
113MAP3K30.54531587
114SIK20.53169756
115FGR0.51773279
116RAF10.51130898
117BMPR20.50435017
118EGFR0.50267987
119PIM20.48734765
120ROCK20.46726107
121FES0.46368891
122NTRK10.45814521
123FER0.45804766
124MAPKAPK20.45350546
125ZAK0.44546709
126SGK20.43724062
127RPS6KL10.42850799
128RPS6KC10.42850799
129NLK0.40176446
130ATR0.38006147
131TGFBR10.33857813
132PAK20.33785900
133YES10.33155820
134INSR0.32470001
135PIK3CG0.32400427
136IGF1R0.32058605
137DDR20.31451786
138DMPK0.31361423

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.82798051
2Leishmaniasis_Homo sapiens_hsa051402.75694564
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.33675274
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19922206
5Osteoclast differentiation_Homo sapiens_hsa043802.13125575
6Malaria_Homo sapiens_hsa051442.06393434
7Measles_Homo sapiens_hsa051622.00191022
8B cell receptor signaling pathway_Homo sapiens_hsa046621.98993244
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96981938
10Legionellosis_Homo sapiens_hsa051341.77971779
11Toxoplasmosis_Homo sapiens_hsa051451.77602148
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.74363767
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74123230
14Pertussis_Homo sapiens_hsa051331.69883364
15Herpes simplex infection_Homo sapiens_hsa051681.69791828
16Influenza A_Homo sapiens_hsa051641.67419684
17TNF signaling pathway_Homo sapiens_hsa046681.66855186
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66336748
19Tuberculosis_Homo sapiens_hsa051521.57265383
20Allograft rejection_Homo sapiens_hsa053301.54154333
21Hematopoietic cell lineage_Homo sapiens_hsa046401.53167109
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.51992912
23Graft-versus-host disease_Homo sapiens_hsa053321.50408932
24Viral myocarditis_Homo sapiens_hsa054161.48770910
25Primary immunodeficiency_Homo sapiens_hsa053401.44907245
26Antigen processing and presentation_Homo sapiens_hsa046121.44594976
27Small cell lung cancer_Homo sapiens_hsa052221.41425306
28Renal cell carcinoma_Homo sapiens_hsa052111.40690884
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40035623
30Chronic myeloid leukemia_Homo sapiens_hsa052201.39451164
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39290861
32Caffeine metabolism_Homo sapiens_hsa002321.39036024
33Apoptosis_Homo sapiens_hsa042101.36268505
34Hepatitis B_Homo sapiens_hsa051611.32916293
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.30547966
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29854642
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24258294
38Shigellosis_Homo sapiens_hsa051311.24179586
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23400293
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22425978
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22141825
42Complement and coagulation cascades_Homo sapiens_hsa046101.21507731
43Salmonella infection_Homo sapiens_hsa051321.20113091
44Thyroid cancer_Homo sapiens_hsa052161.20006482
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17732078
46Acute myeloid leukemia_Homo sapiens_hsa052211.17715900
47Chemokine signaling pathway_Homo sapiens_hsa040621.14964823
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12819906
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10717816
50Asthma_Homo sapiens_hsa053101.09353133
51Glioma_Homo sapiens_hsa052141.07748545
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.06442891
53Proteoglycans in cancer_Homo sapiens_hsa052051.05922869
54Amoebiasis_Homo sapiens_hsa051461.05813633
55VEGF signaling pathway_Homo sapiens_hsa043701.05534368
56Pancreatic cancer_Homo sapiens_hsa052121.03371204
57* MicroRNAs in cancer_Homo sapiens_hsa052061.02528002
58ECM-receptor interaction_Homo sapiens_hsa045121.01934845
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99968053
60Platelet activation_Homo sapiens_hsa046110.98851422
61Lysosome_Homo sapiens_hsa041420.98213748
62Hepatitis C_Homo sapiens_hsa051600.97914187
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.95664881
64ErbB signaling pathway_Homo sapiens_hsa040120.95548191
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95215975
66* Notch signaling pathway_Homo sapiens_hsa043300.94448697
67Other glycan degradation_Homo sapiens_hsa005110.93332782
68Focal adhesion_Homo sapiens_hsa045100.92636354
69T cell receptor signaling pathway_Homo sapiens_hsa046600.92062245
70Adherens junction_Homo sapiens_hsa045200.89513308
71Lysine degradation_Homo sapiens_hsa003100.88414206
72HTLV-I infection_Homo sapiens_hsa051660.88275713
73Choline metabolism in cancer_Homo sapiens_hsa052310.85959636
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85414923
75GnRH signaling pathway_Homo sapiens_hsa049120.85396674
76Inositol phosphate metabolism_Homo sapiens_hsa005620.83533087
77Viral carcinogenesis_Homo sapiens_hsa052030.81551361
78African trypanosomiasis_Homo sapiens_hsa051430.80712459
79Estrogen signaling pathway_Homo sapiens_hsa049150.80681584
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80164563
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.79815900
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79195081
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78444322
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.73434902
85Autoimmune thyroid disease_Homo sapiens_hsa053200.73309113
86Prolactin signaling pathway_Homo sapiens_hsa049170.73077420
87Endocytosis_Homo sapiens_hsa041440.71694630
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71427789
89Melanoma_Homo sapiens_hsa052180.70594282
90Rap1 signaling pathway_Homo sapiens_hsa040150.70578133
91Epstein-Barr virus infection_Homo sapiens_hsa051690.68738460
92Prostate cancer_Homo sapiens_hsa052150.68204252
93Phagosome_Homo sapiens_hsa041450.65612902
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64495834
95Insulin resistance_Homo sapiens_hsa049310.64237135
96p53 signaling pathway_Homo sapiens_hsa041150.64085509
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63677571
98Insulin signaling pathway_Homo sapiens_hsa049100.63401323
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62064466
100Rheumatoid arthritis_Homo sapiens_hsa053230.59680599
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.59303053
102Dilated cardiomyopathy_Homo sapiens_hsa054140.59130684
103Systemic lupus erythematosus_Homo sapiens_hsa053220.56704649
104Pathways in cancer_Homo sapiens_hsa052000.55733362
105TGF-beta signaling pathway_Homo sapiens_hsa043500.54977453
106Non-small cell lung cancer_Homo sapiens_hsa052230.54917962
107Protein digestion and absorption_Homo sapiens_hsa049740.54891409
108* Dorso-ventral axis formation_Homo sapiens_hsa043200.54351769
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52648966
110HIF-1 signaling pathway_Homo sapiens_hsa040660.52165160
111One carbon pool by folate_Homo sapiens_hsa006700.52024587
112FoxO signaling pathway_Homo sapiens_hsa040680.51422949
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49978490
114ABC transporters_Homo sapiens_hsa020100.45977815
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44213914
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43835808
117Colorectal cancer_Homo sapiens_hsa052100.41116310
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36692625
119Prion diseases_Homo sapiens_hsa050200.35410016
120Endometrial cancer_Homo sapiens_hsa052130.34700063
121Bladder cancer_Homo sapiens_hsa052190.34205495
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31765261
123mTOR signaling pathway_Homo sapiens_hsa041500.30392246
124* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29759027
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29734043
126Basal cell carcinoma_Homo sapiens_hsa052170.29080492

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