ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of molecule of bacterial origin (GO:0032490)	4.30222149
2	protein K11-linked deubiquitination (GO:0035871)	4.14908163
3	cellular response to ethanol (GO:0071361)	4.00086381
4	microglial cell activation (GO:0001774)	3.96289089
5	monoubiquitinated protein deubiquitination (GO:0035520)	3.77155253
6	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.73520148
7	positive regulation of gamma-delta T cell activation (GO:0046645)	3.61933538
8	regulation of B cell receptor signaling pathway (GO:0050855)	3.43253513
9	interleukin-6-mediated signaling pathway (GO:0070102)	3.41987549
10	hepatocyte apoptotic process (GO:0097284)	3.36408720
11	interkinetic nuclear migration (GO:0022027)	3.35058176
12	protein targeting to lysosome (GO:0006622)	3.27878437
13	establishment of protein localization to vacuole (GO:0072666)	3.27878437
14	protein targeting to vacuole (GO:0006623)	3.27878437
15	establishment of protein localization to Golgi (GO:0072600)	3.26967588
16	macrophage activation involved in immune response (GO:0002281)	3.25592488
17	mature B cell differentiation involved in immune response (GO:0002313)	3.24675888
18	histone mRNA catabolic process (GO:0071044)	3.21666670
19	positive regulation of mast cell degranulation (GO:0043306)	3.11982795
20	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.11982795
21	positive regulation of mast cell activation (GO:0033005)	3.11917130
22	neutrophil mediated immunity (GO:0002446)	3.11068186
23	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	3.10187046
24	mature B cell differentiation (GO:0002335)	3.09422426
25	cellular extravasation (GO:0045123)	3.07160196
26	macrophage activation (GO:0042116)	3.04411728
27	negative regulation of complement activation (GO:0045916)	3.02913184
28	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.00658886
29	protein K63-linked deubiquitination (GO:0070536)	2.99543538
30	protein K48-linked deubiquitination (GO:0071108)	2.97479647
31	positive regulation of granulocyte differentiation (GO:0030854)	2.96804911
32	regulation of gamma-delta T cell activation (GO:0046643)	2.92568553
33	detection of external biotic stimulus (GO:0098581)	2.91198846
34	neutrophil activation involved in immune response (GO:0002283)	2.88453353
35	regulation of mast cell activation (GO:0033003)	2.86441035
36	positive regulation by symbiont of host defense response (GO:0052509)	2.83579748
37	modulation by symbiont of host defense response (GO:0052031)	2.83579748
38	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.83579748
39	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.83579748
40	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.83579748
41	modulation by symbiont of host immune response (GO:0052553)	2.83579748
42	regulation of mast cell activation involved in immune response (GO:0033006)	2.81246132
43	regulation of gamma-delta T cell differentiation (GO:0045586)	2.81082512
44	fibroblast migration (GO:0010761)	2.79851666
45	response to peptidoglycan (GO:0032494)	2.79168597
46	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.78313073
47	regulation of establishment of cell polarity (GO:2000114)	2.77442519
48	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.77213580
49	definitive hemopoiesis (GO:0060216)	2.75349846
50	lipid translocation (GO:0034204)	2.74202975
51	phospholipid translocation (GO:0045332)	2.74202975
52	regulation of pigment cell differentiation (GO:0050932)	2.72815643
53	regulation of hypersensitivity (GO:0002883)	2.68723066
54	negative regulation of B cell proliferation (GO:0030889)	2.66356733
55	positive regulation of developmental pigmentation (GO:0048087)	2.65850116
56	protein targeting to Golgi (GO:0000042)	2.63978735
57	negative regulation of protein activation cascade (GO:2000258)	2.63438825
58	negative regulation of interleukin-12 production (GO:0032695)	2.61079379
59	negative regulation of interleukin-8 production (GO:0032717)	2.60808821
60	regulation of mast cell degranulation (GO:0043304)	2.59235727
61	B cell receptor signaling pathway (GO:0050853)	2.56902782
62	regulation of germinal center formation (GO:0002634)	2.54400672
63	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.54080721
64	myeloid leukocyte mediated immunity (GO:0002444)	2.52023782
65	iron ion import (GO:0097286)	2.51471586
66	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	2.47191050
67	regulation of necroptotic process (GO:0060544)	2.46169815
68	T-helper 1 type immune response (GO:0042088)	2.45572551
69	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.45345402
70	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.45309193
71	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.44153932
72	negative regulation of humoral immune response (GO:0002921)	2.43871808
73	myeloid cell activation involved in immune response (GO:0002275)	2.43313647
74	detection of biotic stimulus (GO:0009595)	2.42938153
75	histone H3-K4 trimethylation (GO:0080182)	2.41697618
76	response to host immune response (GO:0052572)	2.41666045
77	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.41666045
78	early endosome to late endosome transport (GO:0045022)	2.41180154
79	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.38796023
80	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.36684425
81	regulation of interferon-beta biosynthetic process (GO:0045357)	2.36091117
82	germinal center formation (GO:0002467)	2.33725768
83	negative regulation of interleukin-17 production (GO:0032700)	2.32974128
84	detection of other organism (GO:0098543)	2.32534308
85	response to host (GO:0075136)	2.31914463
86	response to host defenses (GO:0052200)	2.31914463
87	response to defenses of other organism involved in symbiotic interaction (GO:0052173)	2.31914463
88	histone H3-K36 demethylation (GO:0070544)	2.31712997
89	gonadal mesoderm development (GO:0007506)	2.31207056
90	regulation of B cell proliferation (GO:0030888)	2.30112489
91	neutrophil activation (GO:0042119)	2.28647659
92	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.28071336
93	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	2.27333266
94	positive regulation of chemokine secretion (GO:0090197)	2.26630158
95	neural tube formation (GO:0001841)	2.26504776
96	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.25374599
97	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.24599781
98	regulation of tumor necrosis factor biosynthetic process (GO:0042534)	2.23688905
99	protein localization to lysosome (GO:0061462)	2.23535313
100	protein localization to vacuole (GO:0072665)	2.23535313

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.76575247
2	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.66124004
3	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.61274169
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69974850
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.66023740
6	* ESR1_20079471_ChIP-ChIP_T-47D_Human	2.63281060
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.58216205
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.45094771
9	SCL_19346495_ChIP-Seq_HPC-7_Human	2.28517617
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.25620178
11	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	2.21618406
12	TP53_16413492_ChIP-PET_HCT116_Human	2.06017270
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.94881341
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92269904
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92072967
16	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.89374039
17	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.89338198
18	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.88722124
19	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.88026325
20	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.85974268
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.79921435
22	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.78864091
23	VDR_24787735_ChIP-Seq_THP-1_Human	1.70996533
24	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.70108227
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.70041002
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.68041840
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.64551754
28	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.64393748
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.61584327
30	GATA1_22025678_ChIP-Seq_K562_Human	1.59154734
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.58861991
32	AHR_22903824_ChIP-Seq_MCF-7_Human	1.58114053
33	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.56725070
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54153243
35	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.53978721
36	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.50271415
37	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.50271415
38	* CJUN_26792858_Chip-Seq_BT549_Human	1.49506901
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48105084
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.47435010
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46136140
42	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.44894985
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44589033
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.41191657
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39439880
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.38605279
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38397229
48	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38311995
49	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.36954187
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35649815
51	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.33991123
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33275900
53	STAT3_23295773_ChIP-Seq_U87_Human	1.32450666
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31543157
55	* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31381156
56	BRD4_25478319_ChIP-Seq_HGPS_Human	1.29881596
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29383072
58	* MYB_26560356_Chip-Seq_TH2_Human	1.28915028
59	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.28223149
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27835176
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24860061
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.24232132
63	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.22706985
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21802574
65	* SPI1_23127762_ChIP-Seq_K562_Human	1.18405216
66	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.18281252
67	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.18169595
68	GATA3_26560356_Chip-Seq_TH2_Human	1.17335175
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16888719
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16841741
71	* TP63_23658742_ChIP-Seq_EP156T_Human	1.16839496
72	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16539012
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14613673
74	P300_19829295_ChIP-Seq_ESCs_Human	1.14356497
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14291181
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.13734966
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.13734966
78	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12847827
79	* TCF4_23295773_ChIP-Seq_U87_Human	1.11853518
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11831181
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.11334058
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11297779
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11227225
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11106849
85	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10557469
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10425626
87	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10393432
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10333032
89	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.10177940
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09389011
91	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.09154136
92	EWS_26573619_Chip-Seq_HEK293_Human	1.08286886
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07677204
94	BCAT_22108803_ChIP-Seq_LS180_Human	1.05695879
95	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05038603
96	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.04265285
97	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.04265285
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04153836
99	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03640298
100	* MYB_26560356_Chip-Seq_TH1_Human	1.01549160

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.24634815
2	MP0003724_increased_susceptibility_to	3.16784254
3	MP0001835_abnormal_antigen_presentation	2.96587557
4	MP0008057_abnormal_DNA_replication	2.46603000
5	MP0000465_gastrointestinal_hemorrhage	2.23696451
6	MP0003656_abnormal_erythrocyte_physiolo	2.21619668
7	MP0000383_abnormal_hair_follicle	2.16861475
8	MP0003950_abnormal_plasma_membrane	2.16632335
9	MP0002009_preneoplasia	2.12669512
10	MP0005464_abnormal_platelet_physiology	2.02639527
11	MP0003763_abnormal_thymus_physiology	2.00948685
12	MP0006054_spinal_hemorrhage	2.00882228
13	MP0001800_abnormal_humoral_immune	1.88207843
14	MP0005275_abnormal_skin_tensile	1.87927276
15	MP0004883_abnormal_blood_vessel	1.83326434
16	MP0005174_abnormal_tail_pigmentation	1.83091706
17	MP0002419_abnormal_innate_immunity	1.82165083
18	MP0000015_abnormal_ear_pigmentation	1.82165033
19	MP0003828_pulmonary_edema	1.72426255
20	MP0005164_abnormal_response_to	1.71513585
21	MP0005397_hematopoietic_system_phenotyp	1.69149974
22	MP0001545_abnormal_hematopoietic_system	1.69149974
23	MP0010678_abnormal_skin_adnexa	1.68550506
24	MP0002452_abnormal_antigen_presenting	1.66602236
25	MP0002166_altered_tumor_susceptibility	1.65794765
26	MP0005310_abnormal_salivary_gland	1.65433401
27	MP0003045_fibrosis	1.64224309
28	MP0000427_abnormal_hair_cycle	1.62612452
29	MP0000371_diluted_coat_color	1.62260621
30	MP0003191_abnormal_cellular_cholesterol	1.58876249
31	MP0002148_abnormal_hypersensitivity_rea	1.57538346
32	MP0002723_abnormal_immune_serum	1.56513804
33	MP0004381_abnormal_hair_follicle	1.52594963
34	MP0003300_gastrointestinal_ulcer	1.51472583
35	MP0009764_decreased_sensitivity_to	1.49961662
36	MP0003303_peritoneal_inflammation	1.48472946
37	MP0003183_abnormal_peptide_metabolism	1.44906415
38	MP0001958_emphysema	1.39243107
39	MP0005000_abnormal_immune_tolerance	1.35506026
40	MP0008260_abnormal_autophagy	1.35503802
41	MP0005025_abnormal_response_to	1.34936414
42	MP0002405_respiratory_system_inflammati	1.32650700
43	MP0002420_abnormal_adaptive_immunity	1.31785067
44	MP0001819_abnormal_immune_cell	1.31610444
45	MP0003195_calcinosis	1.31598296
46	MP0004808_abnormal_hematopoietic_stem	1.30375985
47	MP0002168_other_aberrant_phenotype	1.30255506
48	MP0001851_eye_inflammation	1.28132345
49	MP0000685_abnormal_immune_system	1.27463821
50	MP0003436_decreased_susceptibility_to	1.27334058
51	MP0003091_abnormal_cell_migration	1.22930291
52	MP0009785_altered_susceptibility_to	1.22678508
53	MP0005408_hypopigmentation	1.22575669
54	MP0005075_abnormal_melanosome_morpholog	1.20180601
55	MP0003172_abnormal_lysosome_physiology	1.19076733
56	MP0009697_abnormal_copulation	1.18615064
57	MP0008004_abnormal_stomach_pH	1.18343428
58	MP0001853_heart_inflammation	1.18338327
59	MP0002332_abnormal_exercise_endurance	1.18185313
60	MP0001790_abnormal_immune_system	1.16215417
61	MP0005387_immune_system_phenotype	1.16215417
62	MP0003252_abnormal_bile_duct	1.14850992
63	MP0002396_abnormal_hematopoietic_system	1.14562427
64	MP0004484_altered_response_of	1.11416301
65	MP0002006_tumorigenesis	1.11074286
66	MP0000716_abnormal_immune_system	1.09843093
67	MP0002998_abnormal_bone_remodeling	1.09726792
68	MP0002398_abnormal_bone_marrow	1.07672835
69	MP0008438_abnormal_cutaneous_collagen	1.06856770
70	MP0004947_skin_inflammation	1.05774651
71	MP0009278_abnormal_bone_marrow	1.04020353
72	MP0006082_CNS_inflammation	1.03963023
73	MP0005647_abnormal_sex_gland	1.03100651
74	MP0001845_abnormal_inflammatory_respons	1.03067858
75	MP0000249_abnormal_blood_vessel	1.00795917
76	MP0000689_abnormal_spleen_morphology	0.99161732
77	MP0002095_abnormal_skin_pigmentation	0.93898703
78	MP0005171_absent_coat_pigmentation	0.91652056
79	MP0001533_abnormal_skeleton_physiology	0.91584212
80	MP0005376_homeostasis/metabolism_phenot	0.91460089
81	MP0002928_abnormal_bile_duct	0.89059199
82	MP0002722_abnormal_immune_system	0.88953723
83	MP0010155_abnormal_intestine_physiology	0.87405686
84	MP0005671_abnormal_response_to	0.85232870
85	MP0005058_abnormal_lysosome_morphology	0.83040057
86	MP0010352_gastrointestinal_tract_polyps	0.81585946
87	MP0004043_abnormal_pH_regulation	0.80578656
88	MP0005248_abnormal_Harderian_gland	0.79755080
89	MP0005670_abnormal_white_adipose	0.79323721
90	MP0002429_abnormal_blood_cell	0.77982973
91	MP0008469_abnormal_protein_level	0.77978618
92	MP0001873_stomach_inflammation	0.77631848
93	MP0004084_abnormal_cardiac_muscle	0.77100047
94	MP0005595_abnormal_vascular_smooth	0.76479528
95	MP0003279_aneurysm	0.76122849
96	MP0000767_abnormal_smooth_muscle	0.73462129
97	MP0009115_abnormal_fat_cell	0.72422579
98	MP0000230_abnormal_systemic_arterial	0.70961757
99	MP0009763_increased_sensitivity_to	0.70481967
100	MP0003690_abnormal_glial_cell	0.68042717

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent frontal sinuses (HP:0002688)	3.85807346
2	T lymphocytopenia (HP:0005403)	3.29051643
3	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.20305296
4	Abnormality of T cell number (HP:0011839)	3.17462580
5	Gingival bleeding (HP:0000225)	3.16613470
6	Recurrent bacterial skin infections (HP:0005406)	3.00825887
7	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.91027084
8	Osteolytic defects of the hand bones (HP:0009699)	2.91027084
9	Periodontitis (HP:0000704)	2.90015831
10	Genetic anticipation (HP:0003743)	2.88635399
11	Prolonged bleeding time (HP:0003010)	2.81842578
12	Fair hair (HP:0002286)	2.73455415
13	Abnormality of the frontal sinuses (HP:0002687)	2.71751672
14	Optic neuritis (HP:0100653)	2.69287370
15	Retrobulbar optic neuritis (HP:0100654)	2.69287370
16	Epistaxis (HP:0000421)	2.66746295
17	Orchitis (HP:0100796)	2.65491890
18	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.62840220
19	Recurrent fungal infections (HP:0002841)	2.61873618
20	Spondylolisthesis (HP:0003302)	2.61280344
21	Abnormality of the axillary hair (HP:0100134)	2.60104504
22	Abnormality of secondary sexual hair (HP:0009888)	2.60104504
23	Recurrent abscess formation (HP:0002722)	2.59948984
24	Pulmonary artery stenosis (HP:0004415)	2.57262465
25	Aortic aneurysm (HP:0004942)	2.56542166
26	Myositis (HP:0100614)	2.56028690
27	Mitral stenosis (HP:0001718)	2.53267765
28	Recurrent cutaneous fungal infections (HP:0011370)	2.48355067
29	Chronic mucocutaneous candidiasis (HP:0002728)	2.48355067
30	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.47912813
31	Syringomyelia (HP:0003396)	2.44505872
32	Spinal cord lesions (HP:0100561)	2.44505872
33	Increased cerebral lipofuscin (HP:0011813)	2.41290922
34	Generalized hypopigmentation of hair (HP:0011358)	2.39539061
35	Acute myeloid leukemia (HP:0004808)	2.38105813
36	Stomach cancer (HP:0012126)	2.38066471
37	Papillary thyroid carcinoma (HP:0002895)	2.37661237
38	Eczematoid dermatitis (HP:0000976)	2.32274783
39	Eosinophilia (HP:0001880)	2.31007896
40	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.29881847
41	Hematochezia (HP:0002573)	2.27189739
42	Prostate neoplasm (HP:0100787)	2.27008254
43	Autoimmune thrombocytopenia (HP:0001973)	2.24838114
44	Widely spaced teeth (HP:0000687)	2.23719867
45	Clumsiness (HP:0002312)	2.23599223
46	Hyperventilation (HP:0002883)	2.23115397
47	Deformed sella turcica (HP:0002681)	2.22519168
48	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.21138696
49	Abnormality of liposaccharide metabolism (HP:0010968)	2.19054858
50	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.19054858
51	Abnormality of glycolipid metabolism (HP:0010969)	2.19054858
52	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.18857694
53	Narrow palate (HP:0000189)	2.17820691
54	Recurrent bronchitis (HP:0002837)	2.15605203
55	Autoimmune hemolytic anemia (HP:0001890)	2.15487786
56	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.14416218
57	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.14183635
58	Thyroiditis (HP:0100646)	2.12932666
59	Recurrent skin infections (HP:0001581)	2.12398677
60	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.11976846
61	Neoplasm of the tracheobronchial system (HP:0100552)	2.11178624
62	Conjunctival telangiectasia (HP:0000524)	2.11071109
63	Abnormality of the sella turcica (HP:0002679)	2.10884368
64	Stomatitis (HP:0010280)	2.10462417
65	Colitis (HP:0002583)	2.09646959
66	Subacute progressive viral hepatitis (HP:0006572)	2.08801760
67	Chest pain (HP:0100749)	2.07618236
68	Large earlobe (HP:0009748)	2.07260284
69	Abnormality of the prostate (HP:0008775)	2.05659397
70	Ectropion (HP:0000656)	2.05314571
71	Increased mean platelet volume (HP:0011877)	2.03822707
72	Recurrent viral infections (HP:0004429)	2.03679635
73	Portal hypertension (HP:0001409)	2.02613034
74	Elevated erythrocyte sedimentation rate (HP:0003565)	2.02530454
75	Aortic dissection (HP:0002647)	2.00874068
76	Gingivitis (HP:0000230)	1.99920411
77	Facial diplegia (HP:0001349)	1.99513898
78	Mediastinal lymphadenopathy (HP:0100721)	1.99357009
79	Spontaneous hematomas (HP:0007420)	1.99173997
80	Keratoconjunctivitis sicca (HP:0001097)	1.98969596
81	Arterial thrombosis (HP:0004420)	1.98270346
82	Glucose intolerance (HP:0000833)	1.97827144
83	Hemoptysis (HP:0002105)	1.97496544
84	Gaze-evoked nystagmus (HP:0000640)	1.96464900
85	Menorrhagia (HP:0000132)	1.92319280
86	Keratoconjunctivitis (HP:0001096)	1.91839208
87	Abnormality of the pericardium (HP:0001697)	1.91664677
88	Absent speech (HP:0001344)	1.90102666
89	Pulmonary infiltrates (HP:0002113)	1.89855001
90	Gangrene (HP:0100758)	1.89425387
91	Abnormal platelet volume (HP:0011876)	1.88909109
92	Leukocytosis (HP:0001974)	1.87169239
93	Granulocytopenia (HP:0001913)	1.84320331
94	Viral hepatitis (HP:0006562)	1.83787742
95	Prominent nose (HP:0000448)	1.83195394
96	Abnormality of the epiphyses of the hand (HP:0005924)	1.81847411
97	Macular degeneration (HP:0000608)	1.81837367
98	Metaphyseal dysplasia (HP:0100255)	1.80518652
99	Anhidrosis (HP:0000970)	1.80191934
100	Abnormality of T cells (HP:0002843)	1.80176430

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.84814804
2	BLK	3.48813972
3	TAOK3	3.46950865
4	BMPR1B	2.82131507
5	AKT3	2.71270818
6	PIK3CG	2.54680355
7	BMPR2	1.99504989
8	IKBKE	1.91558616
9	ACVR1B	1.76979270
10	IRAK1	1.75208917
11	SGK2	1.67896929
12	TXK	1.61547377
13	FLT3	1.59729462
14	KIT	1.56713495
15	MAP3K14	1.53183722
16	IKBKB	1.50017095
17	NEK9	1.49689059
18	LATS1	1.47816879
19	TRPM7	1.45996305
20	PTK2B	1.45313651
21	JAK1	1.44231457
22	GRK6	1.42009113
23	PIK3CA	1.39690018
24	TEC	1.35562524
25	MARK3	1.32214724
26	NUAK1	1.31054123
27	JAK3	1.30430277
28	SYK	1.27580247
29	BTK	1.23016258
30	MAP2K3	1.19563943
31	GRK7	1.19506072
32	TGFBR2	1.18290235
33	TYK2	1.17854889
34	MAP4K2	1.17512810
35	CSF1R	1.16659875
36	ZAP70	1.14173631
37	SGK3	1.11930539
38	CDK12	1.09686788
39	MELK	1.07866840
40	CSK	1.07790834
41	NLK	1.05076731
42	CAMK1D	1.00598439
43	CHUK	0.98932703
44	STK38L	0.98342743
45	MYLK	0.97199829
46	MAPK7	0.94866266
47	BRSK2	0.94256543
48	CAMK1G	0.93308679
49	HCK	0.92729708
50	CAMKK2	0.89944380
51	PDGFRB	0.89419565
52	MAP3K3	0.88125988
53	FER	0.87827727
54	CSNK1A1L	0.85450099
55	STK38	0.83711686
56	ERBB2	0.82878085
57	LCK	0.81473769
58	ADRBK1	0.79392154
59	WNK1	0.79233067
60	LYN	0.75767279
61	MAP3K2	0.75197118
62	JAK2	0.74454868
63	FGR	0.74229072
64	EPHA3	0.72349268
65	MAP3K7	0.71821171
66	BRD4	0.71010257
67	SGK223	0.70967531
68	SGK494	0.70967531
69	IRAK4	0.69739978
70	EGFR	0.69221366
71	TBK1	0.68044037
72	STK24	0.65515234
73	PIM1	0.61720611
74	HIPK2	0.60242067
75	CDK6	0.58171796
76	FES	0.57591134
77	RIPK4	0.57324011
78	ABL1	0.56460773
79	PRKAA2	0.55529853
80	MAP3K13	0.54506532
81	ADRBK2	0.54229767
82	TNK2	0.54034774
83	ITK	0.53174129
84	MATK	0.52951418
85	INSRR	0.52872999
86	MARK2	0.52306796
87	YES1	0.51905673
88	NEK6	0.51627632
89	GRK5	0.49849172
90	PLK2	0.49593731
91	FGFR3	0.49344301
92	STK3	0.49025767
93	MST4	0.48894339
94	DYRK3	0.48532230
95	MAP3K1	0.48253358
96	GRK1	0.46237470
97	MAPK11	0.46226696
98	MET	0.43780641
99	PIM2	0.43208697
100	MAP3K6	0.42109764

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.52820897
2	Asthma_Homo sapiens_hsa05310	2.45086130
3	Leishmaniasis_Homo sapiens_hsa05140	2.17764838
4	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.16425839
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.02506994
6	Allograft rejection_Homo sapiens_hsa05330	1.92860706
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.92122460
8	Osteoclast differentiation_Homo sapiens_hsa04380	1.76120589
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.76032888
10	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.75796721
11	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.71976508
12	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.68383502
13	Platelet activation_Homo sapiens_hsa04611	1.67403346
14	Tuberculosis_Homo sapiens_hsa05152	1.62883970
15	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.58559073
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52237478
17	Malaria_Homo sapiens_hsa05144	1.51306241
18	TNF signaling pathway_Homo sapiens_hsa04668	1.45097881
19	Toxoplasmosis_Homo sapiens_hsa05145	1.43704698
20	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.42533714
21	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.42525900
22	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.40127897
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.38375743
24	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.21964037
25	Influenza A_Homo sapiens_hsa05164	1.21613739
26	ABC transporters_Homo sapiens_hsa02010	1.18314082
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.17064027
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13971853
29	Measles_Homo sapiens_hsa05162	1.10699323
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09614686
31	Legionellosis_Homo sapiens_hsa05134	1.09344261
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08633191
33	Circadian rhythm_Homo sapiens_hsa04710	1.07011790
34	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.06397630
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.05005638
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01221526
37	FoxO signaling pathway_Homo sapiens_hsa04068	1.00819327
38	Viral myocarditis_Homo sapiens_hsa05416	1.00283484
39	Complement and coagulation cascades_Homo sapiens_hsa04610	0.99502901
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98381906
41	Acute myeloid leukemia_Homo sapiens_hsa05221	0.96303724
42	Lysosome_Homo sapiens_hsa04142	0.96216073
43	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.94839052
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94225880
45	Non-small cell lung cancer_Homo sapiens_hsa05223	0.91540463
46	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.91510078
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.91245487
48	Regulation of autophagy_Homo sapiens_hsa04140	0.89669128
49	Herpes simplex infection_Homo sapiens_hsa05168	0.87030558
50	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.87000555
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86192173
52	Hepatitis B_Homo sapiens_hsa05161	0.85312450
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84794854
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.82840608
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81814741
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80084978
57	Pertussis_Homo sapiens_hsa05133	0.79788745
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.78738523
59	Pancreatic cancer_Homo sapiens_hsa05212	0.78684135
60	African trypanosomiasis_Homo sapiens_hsa05143	0.75699155
61	Lysine degradation_Homo sapiens_hsa00310	0.75266621
62	Small cell lung cancer_Homo sapiens_hsa05222	0.75083852
63	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.74327801
64	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.74060937
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.73106509
66	Hepatitis C_Homo sapiens_hsa05160	0.72657882
67	Chemokine signaling pathway_Homo sapiens_hsa04062	0.72593166
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71548579
69	Phagosome_Homo sapiens_hsa04145	0.71052160
70	ECM-receptor interaction_Homo sapiens_hsa04512	0.67790455
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.67720840
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64700943
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.64435923
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.63394497
75	mTOR signaling pathway_Homo sapiens_hsa04150	0.63208858
76	Prolactin signaling pathway_Homo sapiens_hsa04917	0.62970174
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.62906171
78	Choline metabolism in cancer_Homo sapiens_hsa05231	0.61838674
79	Prostate cancer_Homo sapiens_hsa05215	0.61412766
80	Amoebiasis_Homo sapiens_hsa05146	0.61144001
81	Insulin resistance_Homo sapiens_hsa04931	0.58434285
82	Focal adhesion_Homo sapiens_hsa04510	0.58375101
83	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.58280795
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55671339
85	Other glycan degradation_Homo sapiens_hsa00511	0.53808908
86	MicroRNAs in cancer_Homo sapiens_hsa05206	0.53663518
87	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.53561082
88	Apoptosis_Homo sapiens_hsa04210	0.53139572
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52624198
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50872034
91	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.49634967
92	Renal cell carcinoma_Homo sapiens_hsa05211	0.49570633
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47031000
94	Histidine metabolism_Homo sapiens_hsa00340	0.46853027
95	Peroxisome_Homo sapiens_hsa04146	0.46248516
96	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.46198794
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45631226
98	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.45614629
99	Linoleic acid metabolism_Homo sapiens_hsa00591	0.45175438
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44373197

NOTCH2NL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »