NOTCH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)6.21375747
2lymph vessel development (GO:0001945)5.76694416
3surfactant homeostasis (GO:0043129)5.33785773
4positive regulation of protein kinase C signaling (GO:0090037)5.29614756
5cardiac myofibril assembly (GO:0055003)5.11574082
6cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.11407939
7blood vessel maturation (GO:0001955)4.97040452
8endothelium development (GO:0003158)4.92955243
9sarcomere organization (GO:0045214)4.90220250
10retina vasculature morphogenesis in camera-type eye (GO:0061299)4.86050237
11bundle of His cell to Purkinje myocyte communication (GO:0086069)4.82405589
12heart trabecula formation (GO:0060347)4.71741285
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.70380348
14plasma membrane repair (GO:0001778)4.63149068
15cell migration involved in sprouting angiogenesis (GO:0002042)4.59228727
16morphogenesis of an endothelium (GO:0003159)4.54288033
17endothelial tube morphogenesis (GO:0061154)4.54288033
18lymphangiogenesis (GO:0001946)4.42319765
19myofibril assembly (GO:0030239)4.36158783
20negative regulation of potassium ion transmembrane transport (GO:1901380)4.27245514
21chemical homeostasis within a tissue (GO:0048875)4.19319508
22basement membrane organization (GO:0071711)4.18810797
23blood vessel endothelial cell migration (GO:0043534)3.98134003
24venous blood vessel morphogenesis (GO:0048845)3.96437308
25positive regulation of vasculogenesis (GO:2001214)3.89884315
26renal filtration (GO:0097205)3.87911898
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.86482675
28glomerular filtration (GO:0003094)3.80776548
29cardiac muscle cell development (GO:0055013)3.71210505
30ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.71143147
31regulation of vasculogenesis (GO:2001212)3.68349624
32endothelial cell differentiation (GO:0045446)3.66933872
33carnitine shuttle (GO:0006853)3.64560960
34regulation of actin filament-based movement (GO:1903115)3.61683484
35cardiac cell development (GO:0055006)3.60478229
36ovulation from ovarian follicle (GO:0001542)3.58730182
37fatty acid transmembrane transport (GO:1902001)3.58548016
38regulation of p38MAPK cascade (GO:1900744)3.56093554
39* patterning of blood vessels (GO:0001569)3.55031347
40ventricular trabecula myocardium morphogenesis (GO:0003222)3.53334550
41coronary vasculature morphogenesis (GO:0060977)3.52699483
42cardiac muscle tissue morphogenesis (GO:0055008)3.45129946
43ventricular cardiac muscle cell action potential (GO:0086005)3.42450956
44cardiac muscle contraction (GO:0060048)3.42044346
45heart trabecula morphogenesis (GO:0061384)3.40149076
46vasculogenesis (GO:0001570)3.39885273
47actomyosin structure organization (GO:0031032)3.39388824
48angiogenesis involved in wound healing (GO:0060055)3.36543812
49trabecula morphogenesis (GO:0061383)3.35613599
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32071660
51muscle filament sliding (GO:0030049)3.32037611
52actin-myosin filament sliding (GO:0033275)3.32037611
53regulation of synapse maturation (GO:0090128)3.29403121
54regulation of vascular permeability (GO:0043114)3.26328025
55regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.25106457
56positive regulation of glomerulus development (GO:0090193)3.24095856
57regulation of cardioblast differentiation (GO:0051890)3.18937710
58regulation of the force of heart contraction (GO:0002026)3.18667593
59glomerular basement membrane development (GO:0032836)3.17355846
60nephron epithelium development (GO:0072009)3.15929166
61trabecula formation (GO:0060343)3.15487936
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.13353069
63muscle tissue morphogenesis (GO:0060415)3.11728844
64regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11472451
65endothelial cell chemotaxis (GO:0035767)3.11330280
66negative regulation of Rho protein signal transduction (GO:0035024)3.10872883
67regulation of tight junction assembly (GO:2000810)3.08996789
68adult heart development (GO:0007512)3.07014608
69* regulation of endothelial cell differentiation (GO:0045601)3.05858322
70tricarboxylic acid cycle (GO:0006099)3.04889953
71epithelial cell-cell adhesion (GO:0090136)3.04160414
72glomerular visceral epithelial cell development (GO:0072015)3.03849448
73regulation of sarcomere organization (GO:0060297)3.03388748
74regulation of synapse structural plasticity (GO:0051823)2.97426065
75endothelial cell migration (GO:0043542)2.97339885
76cell migration involved in heart development (GO:0060973)2.95288963
77gap junction assembly (GO:0016264)2.94412554
78negative regulation of blood vessel endothelial cell migration (GO:0043537)2.92162968
79cell communication by electrical coupling (GO:0010644)2.92102717
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91293330
81regulation of protein kinase C signaling (GO:0090036)2.90315517
82cell communication involved in cardiac conduction (GO:0086065)2.90018154
83adherens junction assembly (GO:0034333)2.89735743
84cardiac muscle hypertrophy (GO:0003300)2.88051768
85negative regulation of potassium ion transport (GO:0043267)2.86535895
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.86225894
87sprouting angiogenesis (GO:0002040)2.85740171
88cAMP biosynthetic process (GO:0006171)2.84543970
89regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.84370787
90blood vessel remodeling (GO:0001974)2.83255335
91embryonic heart tube development (GO:0035050)2.82111136
92positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81797570
93regulation of skeletal muscle contraction (GO:0014819)2.80721252
94negative regulation of heart growth (GO:0061117)2.80514816
95negative regulation of cardiac muscle tissue growth (GO:0055022)2.80514816
96cell-substrate junction assembly (GO:0007044)2.80238023
97regulation of cardiac muscle cell contraction (GO:0086004)2.79379665
98Notch signaling involved in heart development (GO:0061314)2.78931995
99actin-mediated cell contraction (GO:0070252)2.77244591
100cardiac muscle cell proliferation (GO:0060038)2.76812511
101negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.75855098
102positive regulation of p38MAPK cascade (GO:1900745)2.75849833
103carnitine transmembrane transport (GO:1902603)2.73937238
104atrioventricular valve morphogenesis (GO:0003181)2.72102719
105behavioral response to nicotine (GO:0035095)2.71108515
106striated muscle hypertrophy (GO:0014897)2.70524437
107regulation of sequestering of triglyceride (GO:0010889)2.70475363
108negative regulation of endothelial cell migration (GO:0010596)2.70294777
109protein localization to endosome (GO:0036010)2.69875302
110positive regulation of endothelial cell differentiation (GO:0045603)2.68997475
111glomerular epithelial cell development (GO:0072310)2.68964353
112metanephric nephron epithelium development (GO:0072243)2.67399043
113transcytosis (GO:0045056)2.59804202
114renal tubule morphogenesis (GO:0061333)2.58824584
115neuron remodeling (GO:0016322)2.57790306
116positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57034054
117endocrine hormone secretion (GO:0060986)2.50219574
118peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.46536347
119metanephric epithelium development (GO:0072207)2.45312075
120arginine catabolic process (GO:0006527)2.42795226
121dendritic spine morphogenesis (GO:0060997)2.42044110
122positive regulation of urine volume (GO:0035810)2.40240846
123semaphorin-plexin signaling pathway (GO:0071526)2.38612164
124auditory behavior (GO:0031223)2.38005961
125negative regulation of DNA biosynthetic process (GO:2000279)2.37632211
126heart valve formation (GO:0003188)2.36822541
127negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36484401
128positive regulation of metanephros development (GO:0072216)2.34439176
129aorta morphogenesis (GO:0035909)2.33959803
130protein heterotrimerization (GO:0070208)2.32660533
131regulation of establishment or maintenance of cell polarity (GO:0032878)2.28644812
132negative regulation of epithelial cell migration (GO:0010633)2.28120165
133cAMP metabolic process (GO:0046058)2.27043306
134growth hormone receptor signaling pathway (GO:0060396)2.26843816
135triglyceride catabolic process (GO:0019433)2.24729058
136white fat cell differentiation (GO:0050872)2.24382461
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.22914132
138regulation of triglyceride catabolic process (GO:0010896)2.18560698
139negative regulation of angiogenesis (GO:0016525)2.17413054
140neuron maturation (GO:0042551)2.15517570
141cyclic nucleotide biosynthetic process (GO:0009190)2.13246423
142nephron epithelium morphogenesis (GO:0072088)2.13113186
143nephron tubule morphogenesis (GO:0072078)2.13113186
144metanephric tubule development (GO:0072170)2.11982952
145metanephric nephron tubule development (GO:0072234)2.11982952
146negative regulation of blood vessel morphogenesis (GO:2000181)2.11168792
147negative regulation of platelet activation (GO:0010544)2.11107937
148neurotransmitter-gated ion channel clustering (GO:0072578)2.10948429
149cyclic purine nucleotide metabolic process (GO:0052652)2.10016128
150positive regulation of action potential (GO:0045760)2.09687270
151regulation of glomerulus development (GO:0090192)2.09622350
152artery development (GO:0060840)2.09124033
153regulation of blood vessel endothelial cell migration (GO:0043535)2.08073673
154regulation of phospholipid biosynthetic process (GO:0071071)2.06390408
155response to dietary excess (GO:0002021)2.04798962
156ovulation cycle (GO:0042698)2.04655787
157nephron tubule development (GO:0072080)2.04560218
158toxin metabolic process (GO:0009404)2.04037114
159positive regulation of digestive system process (GO:0060456)2.03245473
160regulation of urine volume (GO:0035809)2.02864917
161membrane depolarization during action potential (GO:0086010)2.02032883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.11642839
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.20926540
3CLOCK_20551151_ChIP-Seq_293T_Human3.03067239
4EZH2_22144423_ChIP-Seq_EOC_Human3.02452226
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87741128
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.72361676
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.68712779
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.64109487
9DROSHA_22980978_ChIP-Seq_HELA_Human2.61029093
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.58267075
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.51451545
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.51451545
13ZNF263_19887448_ChIP-Seq_K562_Human2.47725953
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.45423409
15* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.38986829
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.36470764
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30804176
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29938697
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28960293
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.22152639
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16021762
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.11191667
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.11191667
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.11191667
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01473458
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.00201233
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93472496
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92943041
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.90469802
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86010771
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81923294
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80562911
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80542121
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79413302
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77830093
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76927227
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75290041
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.74700860
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73642750
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73642750
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72677339
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71581729
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70228535
44* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69431221
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68489499
46LXR_22292898_ChIP-Seq_THP-1_Human1.67155403
47KDM2B_26808549_Chip-Seq_K562_Human1.64274533
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64131212
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.60268962
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.60170578
51KDM2B_26808549_Chip-Seq_DND41_Human1.59625915
52GBX2_23144817_ChIP-Seq_PC3_Human1.57979234
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55152540
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54019706
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53865656
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.53280791
57RACK7_27058665_Chip-Seq_MCF-7_Human1.53082528
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.52996797
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48427141
60ZNF274_21170338_ChIP-Seq_K562_Hela1.46737820
61* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46350678
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46315081
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45664126
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45196381
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44137519
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44063249
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42941966
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41014223
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40537435
70CTCF_27219007_Chip-Seq_Bcells_Human1.40065120
71* VDR_22108803_ChIP-Seq_LS180_Human1.40053041
72GATA1_19941826_ChIP-Seq_K562_Human1.38064155
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37738043
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.33858664
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.32478750
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31457132
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30490028
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29687231
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29611916
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29555578
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29481453
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27369571
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.27324648
84* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27122032
85GATA1_22025678_ChIP-Seq_K562_Human1.23300129
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22308541
87TCF7_22412390_ChIP-Seq_EML_Mouse1.20968594
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20454546
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20084422
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19689829
91* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19493720
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18548816
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18294961
94* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18097877
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18014263
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.17413892
97MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16603740
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.16109973
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15860212
100BCAT_22108803_ChIP-Seq_LS180_Human1.13848319
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12932250
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.12351524
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07961806
104* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06994654
105REST_21632747_ChIP-Seq_MESCs_Mouse1.06005266
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05787618
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04889684
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04633808
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.04609952
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01485406
111ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01364354
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01344063
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01071057
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00878284
115TP63_22573176_ChIP-Seq_HFKS_Human1.00841866
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.00639804
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99170164
118RXR_22108803_ChIP-Seq_LS180_Human0.98847254
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98707486
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98668308
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98334861
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98312503
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97156779
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97060811
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97022486
126NCOR1_26117541_ChIP-Seq_K562_Human0.96933158
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96360428
128ATF3_27146783_Chip-Seq_COLON_Human0.95809068
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95488464
130AHR_22903824_ChIP-Seq_MCF-7_Human0.94981076
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94675006
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93614009
133TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92495934
134CJUN_26792858_Chip-Seq_BT549_Human0.91645514
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91487750
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91419191
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91010199
138KLF4_19829295_ChIP-Seq_ESCs_Human0.90164582
139ERA_21632823_ChIP-Seq_H3396_Human0.89828997
140AR_21572438_ChIP-Seq_LNCaP_Human0.89715985
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89169221
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.89120868
143P68_20966046_ChIP-Seq_HELA_Human0.88423448
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87868066
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87566579
146* FOXH1_21741376_ChIP-Seq_ESCs_Human0.87285135
147* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87134821
148* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87088744
149* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87086724
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87000393
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.86872500
152PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86677710
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85995735
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.85562279
155TAF2_19829295_ChIP-Seq_ESCs_Human0.84477589
156* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83309746
157CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83103589
158CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82793226
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.82419872
160* OCT4_19829295_ChIP-Seq_ESCs_Human0.81581966
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81429357
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.81428677
163TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80886838
164* MYC_27129775_Chip-Seq_CORNEA_Mouse0.80774300
165BCL6_27268052_Chip-Seq_Bcells_Human0.80427996
166MYC_19829295_ChIP-Seq_ESCs_Human0.80162464
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.80158054
168SMAD4_21799915_ChIP-Seq_A2780_Human0.79163054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.80664259
2MP0004084_abnormal_cardiac_muscle4.78198888
3MP0001879_abnormal_lymphatic_vessel4.07149421
4MP0004272_abnormal_basement_membrane3.95628767
5MP0005167_abnormal_blood-brain_barrier3.89878951
6MP0002837_dystrophic_cardiac_calcinosis3.64294898
7MP0000751_myopathy3.32747510
8MP0004215_abnormal_myocardial_fiber3.14729686
9MP0004036_abnormal_muscle_relaxation3.10231165
10MP0003828_pulmonary_edema3.00793228
11MP0005330_cardiomyopathy2.80974611
12MP0006138_congestive_heart_failure2.62965946
13MP0003705_abnormal_hypodermis_morpholog2.46274639
14MP0008775_abnormal_heart_ventricle2.38534024
15MP0003646_muscle_fatigue2.26755296
16MP0010630_abnormal_cardiac_muscle2.22232258
17MP0001544_abnormal_cardiovascular_syste2.20435086
18MP0005385_cardiovascular_system_phenoty2.20435086
19MP0003279_aneurysm2.14440073
20MP0002972_abnormal_cardiac_muscle2.13195603
21MP0000750_abnormal_muscle_regeneration2.09639789
22MP0000749_muscle_degeneration2.07480248
23MP0004087_abnormal_muscle_fiber2.01969348
24MP0003566_abnormal_cell_adhesion1.96221772
25MP0004130_abnormal_muscle_cell1.91519373
26MP0002933_joint_inflammation1.84780068
27MP0002127_abnormal_cardiovascular_syste1.81805383
28MP0005670_abnormal_white_adipose1.80891268
29MP0004484_altered_response_of1.80230038
30MP0005620_abnormal_muscle_contractility1.75260503
31MP0005503_abnormal_tendon_morphology1.74927112
32MP0000767_abnormal_smooth_muscle1.74164365
33MP0004085_abnormal_heartbeat1.72468585
34MP0005409_darkened_coat_color1.71863059
35MP0003137_abnormal_impulse_conducting1.70271593
36MP0005623_abnormal_meninges_morphology1.66256522
37MP0005165_increased_susceptibility_to1.65915802
38MP0002332_abnormal_exercise_endurance1.62255895
39MP0001958_emphysema1.59901946
40MP0002638_abnormal_pupillary_reflex1.57560993
41MP0005666_abnormal_adipose_tissue1.49735406
42MP0000343_altered_response_to1.49278019
43MP0002106_abnormal_muscle_physiology1.48817541
44MP0008438_abnormal_cutaneous_collagen1.44460463
45MP0002876_abnormal_thyroid_physiology1.43954829
46MP0002128_abnormal_blood_circulation1.35664674
47MP0002925_abnormal_cardiovascular_devel1.34926495
48MP0004185_abnormal_adipocyte_glucose1.34543262
49MP0003136_yellow_coat_color1.33894880
50MP0000266_abnormal_heart_morphology1.32570944
51MP0002269_muscular_atrophy1.30895547
52MP0001501_abnormal_sleep_pattern1.28972070
53MP0001502_abnormal_circadian_rhythm1.22875372
54MP0005369_muscle_phenotype1.22299556
55MP0009278_abnormal_bone_marrow1.20004435
56MP0002138_abnormal_hepatobiliary_system1.19259456
57MP0000759_abnormal_skeletal_muscle1.16145892
58MP0005375_adipose_tissue_phenotype1.15617813
59MP0001614_abnormal_blood_vessel1.15231868
60MP0004510_myositis1.13697358
61MP0004145_abnormal_muscle_electrophysio1.13261446
62MP0000249_abnormal_blood_vessel1.07119885
63MP0005551_abnormal_eye_electrophysiolog1.06699856
64MP0010329_abnormal_lipoprotein_level1.06134002
65MP0003567_abnormal_fetal_cardiomyocyte1.05986687
66MP0004043_abnormal_pH_regulation1.05436581
67MP0003011_delayed_dark_adaptation1.04919733
68MP0000013_abnormal_adipose_tissue1.04581492
69MP0005535_abnormal_body_temperature1.04434874
70MP0003950_abnormal_plasma_membrane1.04167937
71MP0003195_calcinosis1.02432852
72MP0004885_abnormal_endolymph1.02165234
73MP0008961_abnormal_basal_metabolism1.01488381
74MP0005595_abnormal_vascular_smooth1.00637809
75MP0006276_abnormal_autonomic_nervous0.98921531
76MP0002295_abnormal_pulmonary_circulatio0.97873087
77MP0003724_increased_susceptibility_to0.96402665
78MP0000465_gastrointestinal_hemorrhage0.96276443
79MP0009780_abnormal_chondrocyte_physiolo0.95955983
80MP0005448_abnormal_energy_balance0.95045819
81MP0003091_abnormal_cell_migration0.93356923
82MP0000747_muscle_weakness0.93095669
83MP0005275_abnormal_skin_tensile0.92137656
84MP0003191_abnormal_cellular_cholesterol0.89087004
85MP0001986_abnormal_taste_sensitivity0.87651584
86MP0000003_abnormal_adipose_tissue0.87649513
87MP0003879_abnormal_hair_cell0.86159289
88MP0003984_embryonic_growth_retardation0.85979465
89MP0004233_abnormal_muscle_weight0.85206031
90MP0002108_abnormal_muscle_morphology0.84887715
91MP0002088_abnormal_embryonic_growth/wei0.84716896
92MP0001784_abnormal_fluid_regulation0.83799851
93MP0001968_abnormal_touch/_nociception0.83221986
94MP0000230_abnormal_systemic_arterial0.80258679
95MP0001486_abnormal_startle_reflex0.80247880
96MP0003948_abnormal_gas_homeostasis0.78617967
97MP0003221_abnormal_cardiomyocyte_apopto0.75901458
98MP0004782_abnormal_surfactant_physiolog0.75325984
99MP0002086_abnormal_extraembryonic_tissu0.74241632
100MP0001915_intracranial_hemorrhage0.72827936
101MP0000733_abnormal_muscle_development0.71819294
102MP0009745_abnormal_behavioral_response0.70631698
103MP0003300_gastrointestinal_ulcer0.70533668
104MP0003959_abnormal_lean_body0.69689167
105MP0005360_urolithiasis0.68762560
106MP0008875_abnormal_xenobiotic_pharmacok0.68191621
107MP0003045_fibrosis0.68128723
108MP0004381_abnormal_hair_follicle0.68069280
109MP0002118_abnormal_lipid_homeostasis0.67021878
110MP0003690_abnormal_glial_cell0.66412916
111MP0006054_spinal_hemorrhage0.65879036
112MP0005334_abnormal_fat_pad0.65809476
113MP0002249_abnormal_larynx_morphology0.64647758
114MP0002653_abnormal_ependyma_morphology0.64448173
115MP0005380_embryogenesis_phenotype0.64287757
116MP0001672_abnormal_embryogenesis/_devel0.64287757
117MP0002272_abnormal_nervous_system0.62512515
118MP0003935_abnormal_craniofacial_develop0.62005198
119MP0002733_abnormal_thermal_nociception0.61016601
120MP0005187_abnormal_penis_morphology0.60582274
121MP0005388_respiratory_system_phenotype0.60339640
122MP0002133_abnormal_respiratory_system0.60339640
123MP0000049_abnormal_middle_ear0.59778551
124MP0003283_abnormal_digestive_organ0.59712946
125MP0003941_abnormal_skin_development0.59458486
126MP0002932_abnormal_joint_morphology0.58884595
127MP0003638_abnormal_response/metabolism_0.58693841
128MP0002970_abnormal_white_adipose0.58622662
129MP0009115_abnormal_fat_cell0.57374166
130MP0001970_abnormal_pain_threshold0.57373197
131MP0000026_abnormal_inner_ear0.56884783
132MP0004883_abnormal_blood_vessel0.54600694
133MP0003303_peritoneal_inflammation0.54392704
134MP0001175_abnormal_lung_morphology0.53602567
135MP0003122_maternal_imprinting0.50653493
136MP0009643_abnormal_urine_homeostasis0.50484238
137MP0000537_abnormal_urethra_morphology0.50313533
138MP0002971_abnormal_brown_adipose0.50040964
139MP0001756_abnormal_urination0.48055980
140MP0003115_abnormal_respiratory_system0.47167035
141MP0005023_abnormal_wound_healing0.46739756

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.81625240
2Ventricular tachycardia (HP:0004756)5.50483628
3Muscle fiber splitting (HP:0003555)5.24125760
4Polycythemia (HP:0001901)5.03928378
5Increased connective tissue (HP:0009025)4.94009934
6Atrial fibrillation (HP:0005110)4.56694820
7Hyporeflexia of lower limbs (HP:0002600)4.40785018
8Supraventricular arrhythmia (HP:0005115)4.28486263
9Primary atrial arrhythmia (HP:0001692)4.23733822
10Right ventricular cardiomyopathy (HP:0011663)4.19831949
11Cerebral aneurysm (HP:0004944)4.11451996
12Supraventricular tachycardia (HP:0004755)4.06112124
13Difficulty running (HP:0009046)3.94759641
14Lipoatrophy (HP:0100578)3.84538051
15Exercise-induced muscle cramps (HP:0003710)3.72894461
16Hematochezia (HP:0002573)3.71071778
17Lymphangioma (HP:0100764)3.65958672
18Calf muscle hypertrophy (HP:0008981)3.46437080
19Atrioventricular block (HP:0001678)3.46196963
20Esophageal varix (HP:0002040)3.44784306
21Spontaneous hematomas (HP:0007420)3.39590162
22Exercise-induced myalgia (HP:0003738)3.32015822
23Syncope (HP:0001279)3.27121500
24Myoglobinuria (HP:0002913)3.21665191
25Abnormality of the left ventricular outflow tract (HP:0011103)3.13796248
26Subaortic stenosis (HP:0001682)3.13796248
27Asymmetric septal hypertrophy (HP:0001670)3.08986833
28Muscle hypertrophy of the lower extremities (HP:0008968)3.08674366
29Prolonged QT interval (HP:0001657)3.08497448
30Broad metatarsal (HP:0001783)3.08162745
31Abnormality of the calf musculature (HP:0001430)3.06692018
32Heart block (HP:0012722)3.05738245
33Dilated cardiomyopathy (HP:0001644)3.02127082
34Difficulty climbing stairs (HP:0003551)3.01329863
35Decreased circulating renin level (HP:0003351)2.97007772
36Abnormal atrioventricular conduction (HP:0005150)2.94458488
37Bundle branch block (HP:0011710)2.90735299
38EMG: myopathic abnormalities (HP:0003458)2.89754712
39Oligomenorrhea (HP:0000876)2.87485758
40Increased variability in muscle fiber diameter (HP:0003557)2.86199227
41Delayed CNS myelination (HP:0002188)2.86100856
42Myotonia (HP:0002486)2.81196789
43Visceral angiomatosis (HP:0100761)2.80123763
44Aneurysm (HP:0002617)2.75428324
45Mesangial abnormality (HP:0001966)2.72660677
46Abnormality of the nasal mucosa (HP:0000433)2.70373645
47Ventricular arrhythmia (HP:0004308)2.70122395
48Congenital stationary night blindness (HP:0007642)2.70107869
49Palpitations (HP:0001962)2.65713434
50Hemangiomatosis (HP:0007461)2.63182337
51Adactyly (HP:0009776)2.62759631
52Cerebral palsy (HP:0100021)2.57791266
53Skull defect (HP:0001362)2.52822129
54Abnormality of skeletal muscle fiber size (HP:0012084)2.52414139
55Bulbous nose (HP:0000414)2.51620697
56Tubular atrophy (HP:0000092)2.46677752
57Cerebral hemorrhage (HP:0001342)2.46276729
58Ventricular fibrillation (HP:0001663)2.45488810
59Pulmonary artery stenosis (HP:0004415)2.45030064
60Genetic anticipation (HP:0003743)2.41284648
61Protrusio acetabuli (HP:0003179)2.40549067
62Hypoglycemic coma (HP:0001325)2.40153880
63Obstructive sleep apnea (HP:0002870)2.39834611
64Testicular atrophy (HP:0000029)2.37562752
65Keratoconus (HP:0000563)2.36804647
66Increased corneal curvature (HP:0100692)2.36804647
67Hyperlipoproteinemia (HP:0010980)2.36639611
68Mildly elevated creatine phosphokinase (HP:0008180)2.35230751
69Hyperventilation (HP:0002883)2.34372274
70Pigmentary retinal degeneration (HP:0001146)2.34116011
71Neonatal death (HP:0003811)2.31746336
72Abnormal drinking behavior (HP:0030082)2.30399841
73Polydipsia (HP:0001959)2.30399841
74Distal lower limb muscle weakness (HP:0009053)2.29675072
75Occipital encephalocele (HP:0002085)2.28115060
76Congenital hepatic fibrosis (HP:0002612)2.28021968
77Ketoacidosis (HP:0001993)2.27926338
78Rhabdomyolysis (HP:0003201)2.27852328
79Anterior segment dysgenesis (HP:0007700)2.27664539
80Nephronophthisis (HP:0000090)2.26204865
81Cavernous hemangioma (HP:0001048)2.24146254
82Spinal rigidity (HP:0003306)2.23484892
83Abnormality of the renal medulla (HP:0100957)2.22245847
84Tachypnea (HP:0002789)2.18181850
85Hyperinsulinemic hypoglycemia (HP:0000825)2.17391999
86Hemorrhage of the eye (HP:0011885)2.15893648
87Pancreatic cysts (HP:0001737)2.15200946
88Hyperkalemia (HP:0002153)2.14387194
89Absent hand (HP:0004050)2.12861265
90Neoplasm of the heart (HP:0100544)2.12778715
91Abnormality of midbrain morphology (HP:0002418)2.08350507
92Molar tooth sign on MRI (HP:0002419)2.08350507
93Aortic valve stenosis (HP:0001650)2.06971469
94Hemiplegia (HP:0002301)2.06857759
95Facial shape deformation (HP:0011334)2.06370547
96Potter facies (HP:0002009)2.06370547
97Broad-based gait (HP:0002136)2.04020238
98Vitreoretinal degeneration (HP:0000655)2.03561422
99Cystic liver disease (HP:0006706)2.03193613
100Porencephaly (HP:0002132)2.02755110
101Complement deficiency (HP:0004431)2.00743834
102Abnormal EKG (HP:0003115)2.00352371
103Hypoplastic ischia (HP:0003175)1.98296732
104Aortic aneurysm (HP:0004942)1.96548983
105Abnormal rod and cone electroretinograms (HP:0008323)1.94858573
106Abnormality of the renal collecting system (HP:0004742)1.94023317
107Hemiparesis (HP:0001269)1.93850945
108Joint stiffness (HP:0001387)1.93311703
109Type 1 muscle fiber predominance (HP:0003803)1.91654794
110Round ear (HP:0100830)1.91627698
111Pulmonary hypertension (HP:0002092)1.91273743
112Rectal prolapse (HP:0002035)1.90813178
113Abnormality of the renal cortex (HP:0011035)1.90156402
114Polyuria (HP:0000103)1.88504070
115Portal hypertension (HP:0001409)1.88253681
116Nonimmune hydrops fetalis (HP:0001790)1.86985249
117J-shaped sella turcica (HP:0002680)1.86781777
118Areflexia of lower limbs (HP:0002522)1.86416646
119Hypoplasia of the iris (HP:0007676)1.85399752
120Generalized muscle weakness (HP:0003324)1.85143760
121Ulnar claw (HP:0001178)1.84930352
122Stage 5 chronic kidney disease (HP:0003774)1.84576255
123Limited hip movement (HP:0008800)1.84189781
124Attenuation of retinal blood vessels (HP:0007843)1.84174015
125Pancreatic islet-cell hyperplasia (HP:0004510)1.82057204
126Shallow orbits (HP:0000586)1.81807675
127Scotoma (HP:0000575)1.81313838
128Large for gestational age (HP:0001520)1.80210197
129Abnormality of the ischium (HP:0003174)1.80101566
130Conjunctival telangiectasia (HP:0000524)1.79591564
131Mitral valve prolapse (HP:0001634)1.79423598
132Ankle contracture (HP:0006466)1.78652166
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78172258
134Stroke (HP:0001297)1.77631812
135EMG: neuropathic changes (HP:0003445)1.77161010
136Muscle stiffness (HP:0003552)1.76848489
137Wrist flexion contracture (HP:0001239)1.75668874
138Hip contracture (HP:0003273)1.73953314
139Distal lower limb amyotrophy (HP:0008944)1.73678017
140Premature rupture of membranes (HP:0001788)1.73411745
141Abnormality of the hepatic vasculature (HP:0006707)1.73277320
142Tetraparesis (HP:0002273)1.73158929
143Abnormality of the 4th metacarpal (HP:0010012)1.72830442
144Bladder diverticulum (HP:0000015)1.71414947
145Sudden cardiac death (HP:0001645)1.68961238
146Bone cyst (HP:0012062)1.68149729
147Multiple enchondromatosis (HP:0005701)1.67768415
148Venous insufficiency (HP:0005293)1.66748619
149Hyperglycinuria (HP:0003108)1.66303778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.05914121
2KDR4.80202416
3TGFBR23.60502507
4TTN3.18411462
5TRIB32.70745152
6FRK2.56293552
7RIPK12.52266977
8PKN22.28460073
9MYLK2.02501206
10ERN11.91731058
11EPHB21.86224739
12TGFBR11.81879519
13PDGFRA1.73798697
14LMTK21.71301233
15DMPK1.66242886
16PHKG21.62047004
17PHKG11.62047004
18WNK41.60244238
19NTRK31.54813699
20ADRBK21.53028510
21MAP2K61.49982553
22PTK2B1.45891365
23FES1.36560538
24PDK21.35295367
25PDK31.34806383
26PDK41.34806383
27DAPK21.32752414
28TLK11.31327534
29ICK1.30193754
30PAK41.26821918
31PTK61.23626950
32GRK11.23032428
33EPHA31.21713934
34BMPR1B1.19799231
35MUSK1.18630505
36PRKG21.17310649
37BCKDK1.15328513
38KIT1.14732088
39OBSCN1.14148900
40PRKD11.13574378
41TNK21.12657680
42CDK121.08700651
43EPHB11.06893736
44CAMK1D1.05783398
45MAP2K31.03709599
46EPHA21.02587475
47FER1.02344806
48CAMK11.01522006
49MARK10.93818891
50ADRBK10.93108439
51MAPK120.91514498
52MAPK150.89920501
53RPS6KA20.89796081
54PRKAA20.88384025
55LATS10.83636480
56SIK10.81444776
57FGFR40.80079029
58MAP3K100.79022669
59PRKD30.78342444
60MAP4K20.75999081
61CSK0.75676716
62INSRR0.75648149
63CAMK1G0.75498345
64NME10.74545931
65PTK20.73829764
66MAPK130.71973843
67RPS6KA60.71257694
68MAP3K30.70061784
69TAOK30.68948549
70LRRK20.68146967
71PKN10.68072539
72MAP3K70.68024000
73MAPKAPK30.65454119
74PRKAA10.64320260
75NEK10.64102706
76SGK20.62808621
77SGK2230.60783284
78SGK4940.60783284
79MAPK40.60717674
80WNK30.60709390
81CAMK40.60608086
82MTOR0.60179252
83LATS20.59273088
84NLK0.58476928
85PIK3CA0.57081886
86PRKD20.56975742
87PRKCE0.56583036
88ERBB20.56131783
89ITK0.55997934
90TYRO30.53998535
91PDGFRB0.53619487
92CDC42BPA0.53560004
93ROCK10.53368807
94PIK3CG0.53321964
95PAK30.52679455
96STK100.52473624
97MAPK70.52040937
98TEC0.51596437
99GSK3A0.49910633
100NTRK20.49559094
101FGFR30.48744113
102WNK10.48349934
103FLT30.47826414
104SIK20.47383255
105BMX0.47340136
106PAK20.46504363
107PRKCH0.46072445
108ILK0.45902936
109DDR20.45417967
110MARK20.44651514
111PDPK10.44562487
112STK110.44020288
113PINK10.43991293
114HIPK20.43926336
115STK390.42941142
116PRKCG0.42871227
117PRKG10.42733460
118TXK0.42707869
119PRKACA0.42269058
120CAMK2A0.40684890
121GRK70.40075317
122CHUK0.39296667
123MAP4K10.36106707
124MET0.36074523
125ACVR1B0.36001710
126AKT20.35508679
127MAP2K40.35128489
128NTRK10.34079911
129TRPM70.34010234
130MAP3K60.33039437
131STK240.32133539
132AKT30.31231687
133IGF1R0.30914440
134MAP3K110.30511641
135EGFR0.29048018
136MAP2K20.28670275
137SRC0.27856700
138MAP3K10.24826484
139DYRK1B0.24296219
140JAK20.23864481
141GRK50.23280571
142RET0.22937288
143PRKACG0.22611927
144MATK0.22220830
145FGFR20.22216745
146RPS6KL10.21622741
147RPS6KC10.21622741

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.74647518
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.19384243
3Dilated cardiomyopathy_Homo sapiens_hsa054143.09352319
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.90105963
5Fatty acid degradation_Homo sapiens_hsa000712.61472854
6ECM-receptor interaction_Homo sapiens_hsa045122.49484393
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.39862709
8Propanoate metabolism_Homo sapiens_hsa006402.36243924
9Linoleic acid metabolism_Homo sapiens_hsa005912.29613574
10Focal adhesion_Homo sapiens_hsa045102.15607648
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14359323
12Fatty acid metabolism_Homo sapiens_hsa012122.12703278
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04318146
14Cardiac muscle contraction_Homo sapiens_hsa042602.01254451
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96940315
16Adherens junction_Homo sapiens_hsa045201.96853327
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93589322
18PPAR signaling pathway_Homo sapiens_hsa033201.78604148
19Morphine addiction_Homo sapiens_hsa050321.60144049
20Arginine biosynthesis_Homo sapiens_hsa002201.57172201
21Histidine metabolism_Homo sapiens_hsa003401.52911444
22Phototransduction_Homo sapiens_hsa047441.51844255
23Viral myocarditis_Homo sapiens_hsa054161.51055192
24Carbon metabolism_Homo sapiens_hsa012001.50367815
25Fatty acid biosynthesis_Homo sapiens_hsa000611.48940863
26Circadian entrainment_Homo sapiens_hsa047131.44601093
27Small cell lung cancer_Homo sapiens_hsa052221.42484035
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42449986
29Lysine degradation_Homo sapiens_hsa003101.40918090
30Insulin resistance_Homo sapiens_hsa049311.39401192
31Insulin secretion_Homo sapiens_hsa049111.35801632
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35360886
33Ether lipid metabolism_Homo sapiens_hsa005651.33556752
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.33227313
35Nitrogen metabolism_Homo sapiens_hsa009101.32807831
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30542168
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.30167917
38* Notch signaling pathway_Homo sapiens_hsa043301.30119067
39Taste transduction_Homo sapiens_hsa047421.29745280
40Protein digestion and absorption_Homo sapiens_hsa049741.29698193
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28495713
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23950485
43Amoebiasis_Homo sapiens_hsa051461.23865193
44Tight junction_Homo sapiens_hsa045301.22631001
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.21410871
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21266427
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19868034
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19658736
49Phenylalanine metabolism_Homo sapiens_hsa003601.19261843
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17473750
51Tryptophan metabolism_Homo sapiens_hsa003801.17313063
52Glutamatergic synapse_Homo sapiens_hsa047241.16646437
53Bile secretion_Homo sapiens_hsa049761.14655706
54GABAergic synapse_Homo sapiens_hsa047271.12758380
55Proteoglycans in cancer_Homo sapiens_hsa052051.11200181
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.10833280
57Rap1 signaling pathway_Homo sapiens_hsa040151.10720609
58Circadian rhythm_Homo sapiens_hsa047101.09516169
59Pyruvate metabolism_Homo sapiens_hsa006201.06905371
60HIF-1 signaling pathway_Homo sapiens_hsa040661.03367219
61Arachidonic acid metabolism_Homo sapiens_hsa005901.02405530
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02125956
63VEGF signaling pathway_Homo sapiens_hsa043701.02045312
64Serotonergic synapse_Homo sapiens_hsa047261.01927839
65Salivary secretion_Homo sapiens_hsa049701.00348002
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99303084
67Nicotine addiction_Homo sapiens_hsa050330.98947688
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95863486
69Chemical carcinogenesis_Homo sapiens_hsa052040.95412728
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95340056
71Retinol metabolism_Homo sapiens_hsa008300.94842265
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94311681
73AMPK signaling pathway_Homo sapiens_hsa041520.91630562
74Renin secretion_Homo sapiens_hsa049240.90456418
75Sulfur relay system_Homo sapiens_hsa041220.89197997
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.87178968
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86988896
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86782251
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85642770
80Glucagon signaling pathway_Homo sapiens_hsa049220.81311102
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.81026828
82Olfactory transduction_Homo sapiens_hsa047400.80913715
83Tyrosine metabolism_Homo sapiens_hsa003500.80456004
84Platelet activation_Homo sapiens_hsa046110.79649656
85Renal cell carcinoma_Homo sapiens_hsa052110.79089285
86Insulin signaling pathway_Homo sapiens_hsa049100.78845413
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77676429
88Butanoate metabolism_Homo sapiens_hsa006500.75087939
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75004994
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.74554221
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73920392
92Pathways in cancer_Homo sapiens_hsa052000.73626249
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70171489
94Hippo signaling pathway_Homo sapiens_hsa043900.69732499
95Basal cell carcinoma_Homo sapiens_hsa052170.69697485
96* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69244806
97Cholinergic synapse_Homo sapiens_hsa047250.68786408
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68558229
99* Dorso-ventral axis formation_Homo sapiens_hsa043200.68287341
100beta-Alanine metabolism_Homo sapiens_hsa004100.67599859
101Arginine and proline metabolism_Homo sapiens_hsa003300.67471327
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65999234
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.65676465
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65664395
105Toxoplasmosis_Homo sapiens_hsa051450.65581704
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65287211
107Complement and coagulation cascades_Homo sapiens_hsa046100.64127005
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63612235
109Fat digestion and absorption_Homo sapiens_hsa049750.59620583
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.59493619
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59369862
112Axon guidance_Homo sapiens_hsa043600.58328697
113Biosynthesis of amino acids_Homo sapiens_hsa012300.57769365
114Gap junction_Homo sapiens_hsa045400.57025819
115Ovarian steroidogenesis_Homo sapiens_hsa049130.56223873
116Regulation of autophagy_Homo sapiens_hsa041400.55924469
117Cocaine addiction_Homo sapiens_hsa050300.55644070
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55372902
119Caffeine metabolism_Homo sapiens_hsa002320.54892588
120mTOR signaling pathway_Homo sapiens_hsa041500.54462301
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.54326018
122cAMP signaling pathway_Homo sapiens_hsa040240.53450480
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53137656
124Estrogen signaling pathway_Homo sapiens_hsa049150.52733508
125GnRH signaling pathway_Homo sapiens_hsa049120.52694816
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.52439148
127Gastric acid secretion_Homo sapiens_hsa049710.52410096
128Pancreatic secretion_Homo sapiens_hsa049720.52405494
129TGF-beta signaling pathway_Homo sapiens_hsa043500.50957661
130Starch and sucrose metabolism_Homo sapiens_hsa005000.50855148
131Dopaminergic synapse_Homo sapiens_hsa047280.50676123
132Renin-angiotensin system_Homo sapiens_hsa046140.49717782
133Glycerolipid metabolism_Homo sapiens_hsa005610.49695473
134Long-term depression_Homo sapiens_hsa047300.49548364
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.47391054
136Ras signaling pathway_Homo sapiens_hsa040140.43537660
137Oxytocin signaling pathway_Homo sapiens_hsa049210.42115233
138* MicroRNAs in cancer_Homo sapiens_hsa052060.41911586
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38598727
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37766160
141ABC transporters_Homo sapiens_hsa020100.37638715
142Fatty acid elongation_Homo sapiens_hsa000620.37235418
143Galactose metabolism_Homo sapiens_hsa000520.33551997
144Type II diabetes mellitus_Homo sapiens_hsa049300.33272634
145Parkinsons disease_Homo sapiens_hsa050120.32921715
146Melanogenesis_Homo sapiens_hsa049160.32560037
147Chronic myeloid leukemia_Homo sapiens_hsa052200.32203451
148Bladder cancer_Homo sapiens_hsa052190.31604460
149Calcium signaling pathway_Homo sapiens_hsa040200.30921238
150Fructose and mannose metabolism_Homo sapiens_hsa000510.30258302
151Acute myeloid leukemia_Homo sapiens_hsa052210.29177214

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