NOTUM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.96953449
2transcription from mitochondrial promoter (GO:0006390)8.29733611
3embryonic process involved in female pregnancy (GO:0060136)7.58245491
4plasma lipoprotein particle assembly (GO:0034377)7.49024797
5negative regulation of fibrinolysis (GO:0051918)7.37876731
6peptidyl-glutamic acid carboxylation (GO:0017187)7.10543176
7protein carboxylation (GO:0018214)7.10543176
8replication fork processing (GO:0031297)6.94267237
9protein-lipid complex assembly (GO:0065005)6.68858442
10low-density lipoprotein particle remodeling (GO:0034374)6.64659383
11positive regulation of protein homooligomerization (GO:0032464)6.49329267
12oxidative demethylation (GO:0070989)6.23473394
13regulation of apoptotic cell clearance (GO:2000425)6.22804270
14establishment of apical/basal cell polarity (GO:0035089)6.19750705
15regulation of fibrinolysis (GO:0051917)6.18264265
16regulation of integrin activation (GO:0033623)6.04194503
17regulation of protein homooligomerization (GO:0032462)5.88855312
18cholesterol efflux (GO:0033344)5.66817685
19protein-lipid complex remodeling (GO:0034368)5.64178561
20macromolecular complex remodeling (GO:0034367)5.64178561
21plasma lipoprotein particle remodeling (GO:0034369)5.64178561
22regulation of protein activation cascade (GO:2000257)5.61111626
23DNA deamination (GO:0045006)5.57597843
24regulation of complement activation (GO:0030449)5.56997322
25glutamine family amino acid biosynthetic process (GO:0009084)5.54046133
26plasma lipoprotein particle organization (GO:0071827)5.52460739
27maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.52101230
28regulation of cholesterol esterification (GO:0010872)5.51362221
29establishment or maintenance of monopolar cell polarity (GO:0061339)5.34769619
30establishment of monopolar cell polarity (GO:0061162)5.34769619
31mitochondrial DNA metabolic process (GO:0032042)5.31082210
32protein-lipid complex subunit organization (GO:0071825)5.20646610
33lung epithelium development (GO:0060428)5.20160536
34negative regulation of fatty acid biosynthetic process (GO:0045717)5.19886455
35sulfur amino acid catabolic process (GO:0000098)5.14763244
36low-density lipoprotein particle clearance (GO:0034383)5.14016877
37plasma lipoprotein particle clearance (GO:0034381)5.11383072
38regulation of plasminogen activation (GO:0010755)4.98491799
39blood coagulation, intrinsic pathway (GO:0007597)4.92794170
40regulation of cholesterol biosynthetic process (GO:0045540)4.91745437
41somatic diversification of immune receptors via somatic mutation (GO:0002566)4.88699265
42somatic hypermutation of immunoglobulin genes (GO:0016446)4.88699265
43embryonic placenta development (GO:0001892)4.88109883
44high-density lipoprotein particle remodeling (GO:0034375)4.82148365
45poly(A)+ mRNA export from nucleus (GO:0016973)4.74027897
46DNA strand renaturation (GO:0000733)4.73067396
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63270502
48mitotic G1 DNA damage checkpoint (GO:0031571)4.58961556
49intestinal absorption (GO:0050892)4.55187555
50regulation of bile acid biosynthetic process (GO:0070857)4.49015121
51reverse cholesterol transport (GO:0043691)4.45185247
52cellular response to ATP (GO:0071318)4.38659228
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.37680015
54negative regulation of JAK-STAT cascade (GO:0046426)4.32367353
55regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.19531901
56negative regulation of protein oligomerization (GO:0032460)4.19261268
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18550308
58L-phenylalanine catabolic process (GO:0006559)4.18550308
59regulation of non-canonical Wnt signaling pathway (GO:2000050)4.16624398
60mRNA cleavage (GO:0006379)4.14189525
61regulation of translational fidelity (GO:0006450)4.11832466
62negative regulation of cell cycle arrest (GO:0071157)4.11788978
63mitotic G1/S transition checkpoint (GO:0044819)4.10087313
64viral mRNA export from host cell nucleus (GO:0046784)4.08185722
65alkaloid metabolic process (GO:0009820)4.07183744
66positive regulation of hormone metabolic process (GO:0032352)4.07082703
67G1 DNA damage checkpoint (GO:0044783)4.05426512
68very-low-density lipoprotein particle assembly (GO:0034379)3.99956145
69negative regulation of sterol transport (GO:0032372)3.98986802
70negative regulation of cholesterol transport (GO:0032375)3.98986802
71positive regulation of hormone biosynthetic process (GO:0046886)3.97313519
72negative regulation of protein activation cascade (GO:2000258)3.96334973
73negative regulation of Ras GTPase activity (GO:0034261)3.92551711
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.89572678
75diacylglycerol metabolic process (GO:0046339)3.82128864
76positive regulation of extracellular matrix organization (GO:1903055)3.78941937
77receptor catabolic process (GO:0032801)3.77124802
78glutamate metabolic process (GO:0006536)3.76158714
79spliceosomal tri-snRNP complex assembly (GO:0000244)3.75418386
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.74941348
81positive regulation of steroid metabolic process (GO:0045940)3.74775108
82lipoprotein metabolic process (GO:0042157)3.74705049
83convergent extension (GO:0060026)3.74439432
84cellular zinc ion homeostasis (GO:0006882)3.73588311
85DNA integration (GO:0015074)3.70286952
86positive regulation of protein oligomerization (GO:0032461)3.68844016
87positive regulation by host of viral transcription (GO:0043923)3.67243453
88vitamin transmembrane transport (GO:0035461)3.66628446
89regulation of protein oligomerization (GO:0032459)3.65607403
90cholesterol transport (GO:0030301)3.65103100
91sterol transport (GO:0015918)3.65103100
92embryonic camera-type eye development (GO:0031076)3.65062903
93glial cell migration (GO:0008347)3.62897305
94positive regulation of developmental pigmentation (GO:0048087)3.62697148
95positive regulation of fatty acid biosynthetic process (GO:0045723)3.59678859
96cholesterol homeostasis (GO:0042632)3.59350360
97mitochondrial RNA metabolic process (GO:0000959)3.57480920
98sterol homeostasis (GO:0055092)3.56274830
99base-excision repair (GO:0006284)3.54105684
100face development (GO:0060324)3.51845623
101positive regulation of blood coagulation (GO:0030194)3.51567832
102positive regulation of hemostasis (GO:1900048)3.51567832
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.46825165
104regulation of extracellular matrix organization (GO:1903053)3.43893464
105regulation of cholesterol metabolic process (GO:0090181)3.43501068
106intestinal cholesterol absorption (GO:0030299)3.42469031
107cellular response to zinc ion (GO:0071294)3.40782594
108anatomical structure regression (GO:0060033)3.40357996
109formation of translation preinitiation complex (GO:0001731)3.40189754
110embryonic retina morphogenesis in camera-type eye (GO:0060059)3.38926511
111phospholipid efflux (GO:0033700)3.35677998
112non-recombinational repair (GO:0000726)3.35310297
113double-strand break repair via nonhomologous end joining (GO:0006303)3.35310297
114pinocytosis (GO:0006907)3.35050488
115complement activation, alternative pathway (GO:0006957)3.32768973
116histone H4-K12 acetylation (GO:0043983)3.32620416
117apoptotic process involved in morphogenesis (GO:0060561)3.31097418
118basement membrane organization (GO:0071711)3.30485876
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29266358
120acute-phase response (GO:0006953)3.29034845
121trivalent inorganic anion homeostasis (GO:0072506)3.27727304
122phosphate ion homeostasis (GO:0055062)3.27727304
123heme transport (GO:0015886)3.27253732
124negative regulation of complement activation (GO:0045916)3.27186747
125trophectodermal cell differentiation (GO:0001829)3.25138740
126renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.24206632
127positive regulation of triglyceride lipase activity (GO:0061365)3.23407375
128positive regulation of lipoprotein lipase activity (GO:0051006)3.23407375
129modified amino acid transport (GO:0072337)3.22415977
130nephron tubule morphogenesis (GO:0072078)3.22340674
131nephron epithelium morphogenesis (GO:0072088)3.22340674
132negative regulation of fatty acid metabolic process (GO:0045922)3.20994633
133regulation of extracellular matrix disassembly (GO:0010715)3.19468135
134regulation of sister chromatid cohesion (GO:0007063)3.19111903
135eye photoreceptor cell differentiation (GO:0001754)3.19011780
136photoreceptor cell differentiation (GO:0046530)3.19011780
137positive regulation of coagulation (GO:0050820)3.17722669
138base-excision repair, AP site formation (GO:0006285)3.17061400
139negative regulation of sodium ion transport (GO:0010766)3.16272725
140labyrinthine layer development (GO:0060711)3.16129814
141cell proliferation involved in metanephros development (GO:0072203)3.15924591
142dosage compensation (GO:0007549)3.14133261
143glyoxylate metabolic process (GO:0046487)3.12930394
144regulation of cholesterol homeostasis (GO:2000188)3.12880527
145L-phenylalanine metabolic process (GO:0006558)3.11687595
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11687595
147negative regulation of response to food (GO:0032096)3.09208897
148negative regulation of appetite (GO:0032099)3.09208897
1494-hydroxyproline metabolic process (GO:0019471)3.07822335
150regulation of RNA export from nucleus (GO:0046831)3.07578230
151cytolysis (GO:0019835)3.07234247
152cell proliferation involved in kidney development (GO:0072111)3.06356032
153GDP-mannose metabolic process (GO:0019673)3.05631744
154peptidyl-glutamic acid modification (GO:0018200)3.05144369
155fibrinolysis (GO:0042730)3.04721958
156negative regulation of lipase activity (GO:0060192)3.04195237
157regulation of cholesterol storage (GO:0010885)3.03700823
158regulation of norepinephrine secretion (GO:0014061)3.02490330
159dicarboxylic acid biosynthetic process (GO:0043650)3.02306747
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00843188
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00843188
162positive regulation of mitotic sister chromatid separation (GO:1901970)3.00843188
163telomere maintenance via semi-conservative replication (GO:0032201)2.99809633
164DNA double-strand break processing (GO:0000729)2.99234888
165L-ascorbic acid metabolic process (GO:0019852)2.98758886
166protein targeting to lysosome (GO:0006622)2.98697970
167establishment of protein localization to vacuole (GO:0072666)2.98697970
168protein targeting to vacuole (GO:0006623)2.98697970
169regulation of posttranscriptional gene silencing (GO:0060147)2.98671471
170regulation of gene silencing by miRNA (GO:0060964)2.98671471
171regulation of gene silencing by RNA (GO:0060966)2.98671471
172anterior/posterior axis specification, embryo (GO:0008595)2.98459651
173response to follicle-stimulating hormone (GO:0032354)2.98355836
174negative regulation of blood coagulation (GO:0030195)2.98228593
175negative regulation of hemostasis (GO:1900047)2.98228593
176negative regulation of norepinephrine secretion (GO:0010700)2.98139676
177negative regulation of mRNA processing (GO:0050686)2.97925955
178nodal signaling pathway (GO:0038092)2.97781357
179positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.97767045
180lipid homeostasis (GO:0055088)2.96832012
181positive regulation of DNA repair (GO:0045739)2.95229601
182drinking behavior (GO:0042756)2.94511465
183positive regulation of insulin receptor signaling pathway (GO:0046628)2.93552848
184hypotonic response (GO:0006971)2.91870492
185negative regulation of heart rate (GO:0010459)2.91566072
186acylglycerol homeostasis (GO:0055090)2.90949873
187triglyceride homeostasis (GO:0070328)2.90949873
188activation of Rac GTPase activity (GO:0032863)2.90144458
189DNA topological change (GO:0006265)2.89636641
190regulation of mitochondrial depolarization (GO:0051900)2.89561677
191nucleotide-excision repair, DNA gap filling (GO:0006297)2.89295162
192pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87069568
193proline biosynthetic process (GO:0006561)11.2491434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXA2_19822575_ChIP-Seq_HepG2_Human3.74453614
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.70473596
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.70473596
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.70473596
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.53213409
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.34929514
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.31731079
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.95671505
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.79466420
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76249686
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.68536103
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67748514
13HNF4A_19822575_ChIP-Seq_HepG2_Human2.66432433
14* RXR_22158963_ChIP-Seq_LIVER_Mouse2.64787623
15CLOCK_20551151_ChIP-Seq_293T_Human2.48919451
16POU5F1_16518401_ChIP-PET_MESCs_Mouse2.41461595
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30606165
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29719301
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24969613
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22457827
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.21079884
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.19920163
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.18880596
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17478747
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16043597
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15316939
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12462183
28TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09846194
29VDR_21846776_ChIP-Seq_THP-1_Human2.07316412
30* LXR_22292898_ChIP-Seq_THP-1_Human2.06871956
31AR_21909140_ChIP-Seq_LNCAP_Human2.06450267
32STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03429113
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.00791151
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96782544
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95246554
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.94781886
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94577946
38E2F7_22180533_ChIP-Seq_HELA_Human1.93940210
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.85631428
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.80437652
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78214976
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75707604
43* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.75065368
44ZNF263_19887448_ChIP-Seq_K562_Human1.72690369
45* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67511718
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.65851047
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64637106
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64440677
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64319069
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60936476
51* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58461680
52* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.57388520
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55869441
54RACK7_27058665_Chip-Seq_MCF-7_Human1.55576837
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.54015608
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.53416992
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50992570
58NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50822512
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50626650
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50215665
61* NANOG_21062744_ChIP-ChIP_HESCs_Human1.49832395
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48180101
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47514023
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47400613
65POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.46265252
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44380601
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.40773193
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40719997
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40237989
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39984268
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39781339
72GATA6_25053715_ChIP-Seq_YYC3_Human1.38812025
73GATA4_25053715_ChIP-Seq_YYC3_Human1.38560137
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37745998
75SOX2_18692474_ChIP-Seq_MESCs_Mouse1.36102419
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.35740168
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35021538
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34777219
79GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.34168757
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32284077
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31832326
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.31293784
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30374812
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29952394
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29698961
86TP53_22127205_ChIP-Seq_IMR90_Human1.28813575
87* RARB_24833708_ChIP-Seq_LIVER_Mouse1.27668136
88KDM2B_26808549_Chip-Seq_K562_Human1.25187317
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24470250
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.24063819
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23997035
92PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21883991
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21857124
94ETS1_21867929_ChIP-Seq_TH2_Mouse1.21385793
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20663062
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20224434
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19934906
98NANOG_16518401_ChIP-PET_MESCs_Mouse1.19624336
99* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16898937
100MYC_22102868_ChIP-Seq_BL_Human1.16802132
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16766300
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.16497123
103* RARA_24833708_ChIP-Seq_LIVER_Mouse1.15769252
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13949370
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12210385
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12182945
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11734557
108NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11685088
109KDM2B_26808549_Chip-Seq_DND41_Human1.11322423
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10523904
111* SPI1_26923725_Chip-Seq_HPCs_Mouse1.09968529
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09968260
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09923336
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09503947
115TCF7_22412390_ChIP-Seq_EML_Mouse1.09223310
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09129327
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08952676
118* ATF3_27146783_Chip-Seq_COLON_Human1.07621294
119* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06495343
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06310513
121CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04948171
122* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03659224
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03585262
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03490187
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02398328
126KAP1_27257070_Chip-Seq_ESCs_Mouse1.02129185
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02110732
128ELK3_25401928_ChIP-Seq_HUVEC_Human1.01729913
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00861018
130HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00073904
131YY1_21170310_ChIP-Seq_MESCs_Mouse0.99984151
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99810221
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99603561
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99562190
135* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99538027
136BCOR_27268052_Chip-Seq_Bcells_Human0.99407635
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99131383
138P68_20966046_ChIP-Seq_HELA_Human0.98915405
139PHF8_20622854_ChIP-Seq_HELA_Human0.98775373
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98104167
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.97833050
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97510587
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97453351
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97148128
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96996380
146SMC4_20622854_ChIP-Seq_HELA_Human0.96859447
147TP63_17297297_ChIP-ChIP_HaCaT_Human0.96436511
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96104214
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.94800595
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91746335
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91508529
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90167790
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88440978
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84958379
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83876497
156FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81774424
157AR_21572438_ChIP-Seq_LNCaP_Human0.80861077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.22944019
2MP0008057_abnormal_DNA_replication5.65877449
3MP0000566_synostosis4.43968372
4MP0005171_absent_coat_pigmentation4.23474840
5MP0009278_abnormal_bone_marrow4.08817844
6MP0003123_paternal_imprinting3.98229336
7MP0005085_abnormal_gallbladder_physiolo3.74158346
8MP0010030_abnormal_orbit_morphology3.71127796
9MP0003195_calcinosis3.39643221
10MP0005365_abnormal_bile_salt3.36365821
11MP0002009_preneoplasia3.04456237
12MP0004233_abnormal_muscle_weight3.00237635
13MP0002089_abnormal_postnatal_growth/wei2.78750878
14MP0002139_abnormal_hepatobiliary_system2.68159826
15MP0003283_abnormal_digestive_organ2.56598927
16MP0005360_urolithiasis2.55174226
17MP0003890_abnormal_embryonic-extraembry2.41731849
18MP0008995_early_reproductive_senescence2.33911288
19MP0005451_abnormal_body_composition2.23723427
20MP0004133_heterotaxia2.17579608
21MP0002249_abnormal_larynx_morphology2.17415650
22MP0005408_hypopigmentation2.12850209
23MP0003121_genomic_imprinting2.11066384
24MP0009780_abnormal_chondrocyte_physiolo2.10188313
25MP0001915_intracranial_hemorrhage2.05427931
26MP0003119_abnormal_digestive_system1.98499283
27MP0005257_abnormal_intraocular_pressure1.96609928
28MP0003453_abnormal_keratinocyte_physiol1.96241663
29MP0005409_darkened_coat_color1.91670566
30MP0002653_abnormal_ependyma_morphology1.91308613
31MP0003806_abnormal_nucleotide_metabolis1.90731579
32MP0002282_abnormal_trachea_morphology1.89988336
33MP0006054_spinal_hemorrhage1.87427857
34MP0005397_hematopoietic_system_phenotyp1.86665740
35MP0001545_abnormal_hematopoietic_system1.86665740
36MP0000579_abnormal_nail_morphology1.82715532
37MP0006072_abnormal_retinal_apoptosis1.67727958
38MP0003786_premature_aging1.58757896
39MP0004019_abnormal_vitamin_homeostasis1.55726548
40MP0004272_abnormal_basement_membrane1.55703596
41MP0003315_abnormal_perineum_morphology1.53601280
42MP0010094_abnormal_chromosome_stability1.51960277
43MP0005174_abnormal_tail_pigmentation1.50646387
44MP0001293_anophthalmia1.49516064
45MP0002086_abnormal_extraembryonic_tissu1.49316586
46MP0010352_gastrointestinal_tract_polyps1.49231736
47MP0000462_abnormal_digestive_system1.46510962
48MP0002796_impaired_skin_barrier1.44491525
49MP0005076_abnormal_cell_differentiation1.43489160
50MP0004264_abnormal_extraembryonic_tissu1.42682436
51MP0003942_abnormal_urinary_system1.41621158
52MP0008875_abnormal_xenobiotic_pharmacok1.40370765
53MP0000639_abnormal_adrenal_gland1.39928080
54MP0003172_abnormal_lysosome_physiology1.35678957
55MP0002084_abnormal_developmental_patter1.34754151
56MP0004197_abnormal_fetal_growth/weight/1.31588090
57MP0004957_abnormal_blastocyst_morpholog1.30051162
58MP0005075_abnormal_melanosome_morpholog1.29741086
59MP0000371_diluted_coat_color1.29703914
60MP0005167_abnormal_blood-brain_barrier1.29447952
61MP0003868_abnormal_feces_composition1.27652639
62MP0002269_muscular_atrophy1.26236351
63MP0003385_abnormal_body_wall1.25019493
64MP0002938_white_spotting1.24836039
65MP0001697_abnormal_embryo_size1.21602971
66MP0002132_abnormal_respiratory_system1.20842446
67MP0000470_abnormal_stomach_morphology1.19884064
68MP0003705_abnormal_hypodermis_morpholog1.19308479
69MP0001986_abnormal_taste_sensitivity1.18920194
70MP0005058_abnormal_lysosome_morphology1.18650740
71MP0008260_abnormal_autophagy1.18296408
72MP0003115_abnormal_respiratory_system1.18264404
73MP0002085_abnormal_embryonic_tissue1.18215114
74MP0001661_extended_life_span1.17851577
75MP0001340_abnormal_eyelid_morphology1.16749144
76MP0002092_abnormal_eye_morphology1.15597442
77MP0005266_abnormal_metabolism1.14887786
78MP0001270_distended_abdomen1.13326421
79MP0002111_abnormal_tail_morphology1.12446671
80MP0009053_abnormal_anal_canal1.11359793
81MP0000762_abnormal_tongue_morphology1.10296265
82MP0003567_abnormal_fetal_cardiomyocyte1.07585217
83MP0003950_abnormal_plasma_membrane1.04840882
84MP0003566_abnormal_cell_adhesion1.03996744
85MP0005332_abnormal_amino_acid1.03192517
86MP0001672_abnormal_embryogenesis/_devel1.00994527
87MP0005380_embryogenesis_phenotype1.00994527
88MP0003656_abnormal_erythrocyte_physiolo1.00375327
89MP0003718_maternal_effect0.98990683
90MP0003252_abnormal_bile_duct0.98413513
91MP0002932_abnormal_joint_morphology0.98147014
92MP0008438_abnormal_cutaneous_collagen0.97729779
93MP0002060_abnormal_skin_morphology0.97702013
94MP0010329_abnormal_lipoprotein_level0.97020313
95MP0005248_abnormal_Harderian_gland0.96522559
96MP0009384_cardiac_valve_regurgitation0.96468717
97MP0000490_abnormal_crypts_of0.96454187
98MP0000598_abnormal_liver_morphology0.96133930
99MP0009840_abnormal_foam_cell0.95215707
100MP0000003_abnormal_adipose_tissue0.95067732
101MP0010234_abnormal_vibrissa_follicle0.94525636
102MP0002933_joint_inflammation0.94474461
103MP0008058_abnormal_DNA_repair0.93425388
104MP0000609_abnormal_liver_physiology0.92922831
105MP0003183_abnormal_peptide_metabolism0.92283101
106MP0003878_abnormal_ear_physiology0.91977381
107MP0005377_hearing/vestibular/ear_phenot0.91977381
108MP0008932_abnormal_embryonic_tissue0.91121140
109MP0009115_abnormal_fat_cell0.90210989
110MP0000467_abnormal_esophagus_morphology0.87021716
111MP0008877_abnormal_DNA_methylation0.86832630
112MP0001324_abnormal_eye_pigmentation0.86301452
113MP0005501_abnormal_skin_physiology0.85990179
114MP0001666_abnormal_nutrient_absorption0.84261990
115MP0005636_abnormal_mineral_homeostasis0.82472682
116MP0003755_abnormal_palate_morphology0.81798362
117MP0002909_abnormal_adrenal_gland0.80261816
118MP0003943_abnormal_hepatobiliary_system0.79038012
119MP0000678_abnormal_parathyroid_gland0.78358727
120MP0003935_abnormal_craniofacial_develop0.78242029
121MP0002332_abnormal_exercise_endurance0.75354104
122MP0003045_fibrosis0.75175888
123MP0005647_abnormal_sex_gland0.74557648
124MP0000534_abnormal_ureter_morphology0.73807599
125MP0003111_abnormal_nucleus_morphology0.73474513
126MP0005220_abnormal_exocrine_pancreas0.73240001
127MP0005319_abnormal_enzyme/_coenzyme0.73101589
128MP0002697_abnormal_eye_size0.72828565
129MP0003984_embryonic_growth_retardation0.71192926
130MP0003329_amyloid_beta_deposits0.70960812
131MP0001286_abnormal_eye_development0.70906914
132MP0003941_abnormal_skin_development0.70761662
133MP0003137_abnormal_impulse_conducting0.70075609
134MP0000015_abnormal_ear_pigmentation0.70060586
135MP0002114_abnormal_axial_skeleton0.69870265
136MP0002019_abnormal_tumor_incidence0.69587844
137MP0002118_abnormal_lipid_homeostasis0.69551466
138MP0002075_abnormal_coat/hair_pigmentati0.69361398
139MP0002088_abnormal_embryonic_growth/wei0.68441617
140MP0002080_prenatal_lethality0.68099036
141MP0003638_abnormal_response/metabolism_0.68069420
142MP0001730_embryonic_growth_arrest0.67933482
143MP0005376_homeostasis/metabolism_phenot0.67806748
144MP0002116_abnormal_craniofacial_bone0.67790581
145MP0006082_CNS_inflammation0.67581893
146MP0003828_pulmonary_edema0.67581714
147MP0005367_renal/urinary_system_phenotyp0.67109346
148MP0000516_abnormal_urinary_system0.67109346
149MP0010368_abnormal_lymphatic_system0.65972731
150MP0003632_abnormal_nervous_system0.63785836
151MP0002160_abnormal_reproductive_system0.63402156
152MP0009642_abnormal_blood_homeostasis0.62280981
153MP0000858_altered_metastatic_potential0.61591446
154MP0002233_abnormal_nose_morphology0.61013784
155MP0003879_abnormal_hair_cell0.60551822
156MP0005464_abnormal_platelet_physiology0.60171883
157MP0002098_abnormal_vibrissa_morphology0.57800215
158MP0004185_abnormal_adipocyte_glucose0.56755321
159MP0005670_abnormal_white_adipose0.56722650
160MP0000604_amyloidosis0.56506746
161MP0004134_abnormal_chest_morphology0.55647111
162MP0002166_altered_tumor_susceptibility0.54419841
163MP0005410_abnormal_fertilization0.53441178
164MP0006292_abnormal_olfactory_placode0.53369494

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.22061269
2Joint hemorrhage (HP:0005261)5.73176497
3Rib fusion (HP:0000902)5.45749811
4Hypochromic microcytic anemia (HP:0004840)5.37563163
5Turricephaly (HP:0000262)5.06119341
6Concave nail (HP:0001598)4.94454334
7Pustule (HP:0200039)4.86662434
8Alopecia of scalp (HP:0002293)4.85597916
9Rectal fistula (HP:0100590)4.83026838
10Rectovaginal fistula (HP:0000143)4.83026838
11Annular pancreas (HP:0001734)4.82741173
12Small epiphyses (HP:0010585)4.80471111
13Facial hemangioma (HP:0000329)4.62262728
14Increased IgM level (HP:0003496)4.53003887
15Vaginal fistula (HP:0004320)4.50950049
16Intestinal fistula (HP:0100819)4.29985371
17Abnormality of the common coagulation pathway (HP:0010990)4.29677537
18Ulnar bowing (HP:0003031)4.28275201
19Hemorrhage of the eye (HP:0011885)4.27302527
20Complement deficiency (HP:0004431)4.26758640
21Hypercholesterolemia (HP:0003124)4.26530746
22Xanthomatosis (HP:0000991)4.16064202
23Coronal craniosynostosis (HP:0004440)4.13144132
24Poikiloderma (HP:0001029)4.06366463
25Asymmetry of the thorax (HP:0001555)3.85077939
26Abnormal hemoglobin (HP:0011902)3.74482044
27Short humerus (HP:0005792)3.71693504
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.70127794
29Acanthocytosis (HP:0001927)3.69703568
30Tongue fasciculations (HP:0001308)3.68214564
31Abnormality of carpal bone ossification (HP:0006257)3.67062358
32Glomerulonephritis (HP:0000099)3.63903157
33Aplasia/hypoplasia of the humerus (HP:0006507)3.53351891
34Menorrhagia (HP:0000132)3.51906620
35Hypoplasia of the capital femoral epiphysis (HP:0003090)3.43078466
36Male infertility (HP:0003251)3.41147805
37Muscle fibrillation (HP:0010546)3.37226381
38Broad palm (HP:0001169)3.35321361
39Flat acetabular roof (HP:0003180)3.26462520
40Orthostatic hypotension (HP:0001278)3.25800274
41Abnormality of complement system (HP:0005339)3.25149580
42Intestinal atresia (HP:0011100)3.23468421
43Epiphyseal dysplasia (HP:0002656)3.22932071
44Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.22559224
45Vertebral hypoplasia (HP:0008417)3.22559224
46Hypobetalipoproteinemia (HP:0003563)3.21527722
47Pancreatic islet-cell hyperplasia (HP:0004510)3.16043112
48Abnormal tarsal ossification (HP:0008369)3.11438512
49Mucopolysacchariduria (HP:0008155)3.10572260
50Urinary glycosaminoglycan excretion (HP:0003541)3.10572260
51Anteriorly placed anus (HP:0001545)3.07806864
52Abnormality of male internal genitalia (HP:0000022)3.07407387
53Irregular epiphyses (HP:0010582)3.06018332
54Abnormality of the aortic arch (HP:0012303)3.01761981
55Alacrima (HP:0000522)2.98707745
56Absent radius (HP:0003974)2.92978940
57Epidermoid cyst (HP:0200040)2.92104490
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.82729683
59Absent epiphyses (HP:0010577)2.82729683
60Hypotrichosis (HP:0001006)2.82323035
61Premature skin wrinkling (HP:0100678)2.81807952
62Abnormal hand bone ossification (HP:0010660)2.81254264
63Intrahepatic cholestasis (HP:0001406)2.80176887
64Large for gestational age (HP:0001520)2.79874054
65Abnormal ossification of hand bones (HP:0005921)2.78829557
66Abnormality of polysaccharide metabolism (HP:0011012)2.78316306
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78316306
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78316306
69Squamous cell carcinoma (HP:0002860)2.77721526
70Broad alveolar ridges (HP:0000187)2.77032930
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.76024285
72Dysautonomia (HP:0002459)2.75859388
73Short chin (HP:0000331)2.75696507
74Hypochromic anemia (HP:0001931)2.75620121
75Absent forearm bone (HP:0003953)2.75354024
76Aplasia involving forearm bones (HP:0009822)2.75354024
77Congenital hip dislocation (HP:0001374)2.74648190
78Systemic lupus erythematosus (HP:0002725)2.71284676
79Hepatoblastoma (HP:0002884)2.70698351
80Abnormality of the lumbar spine (HP:0100712)2.64761373
81Diaphragmatic weakness (HP:0009113)2.64514120
82Polycythemia (HP:0001901)2.64235155
83Growth hormone excess (HP:0000845)2.64029174
84Spontaneous abortion (HP:0005268)2.63825651
85Purpura (HP:0000979)2.60824510
86Renal duplication (HP:0000075)2.60494655
87Dysostosis multiplex (HP:0000943)2.56415708
88Choanal stenosis (HP:0000452)2.55418489
89Hamartoma (HP:0010566)2.54942657
90Limited elbow extension (HP:0001377)2.51502575
91Diastasis recti (HP:0001540)2.47525325
92Protrusio acetabuli (HP:0003179)2.47438472
93Vascular calcification (HP:0004934)2.47021580
94Aplasia of the musculature (HP:0100854)2.45293969
95Albinism (HP:0001022)2.43627404
96Bifid uvula (HP:0000193)2.43391966
97Clumsiness (HP:0002312)2.42447919
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41435538
99Hypokinesia (HP:0002375)2.39913451
100Bowing of the arm (HP:0006488)2.38323239
101Bowed forearm bones (HP:0003956)2.38323239
102Basal cell carcinoma (HP:0002671)2.37938587
103Absent thumb (HP:0009777)2.33991826
104Flared iliac wings (HP:0002869)2.31921908
105Joint stiffness (HP:0001387)2.31709504
106Lower limb hyperreflexia (HP:0002395)2.30643320
107Neonatal death (HP:0003811)2.29764163
108Abnormality of the wing of the ilium (HP:0011867)2.28131898
109Vertebral fusion (HP:0002948)2.26389414
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25288682
111Wide nose (HP:0000445)2.24289037
112Hypophosphatemic rickets (HP:0004912)2.22439709
113Abnormality of the nasal septum (HP:0000419)2.21867897
114Capillary hemangiomas (HP:0005306)2.21491462
115Myocardial infarction (HP:0001658)2.20792783
116Abnormality of glycolysis (HP:0004366)2.20236266
117Volvulus (HP:0002580)2.20086461
118Abnormality of the lower motor neuron (HP:0002366)2.19242969
119Skin nodule (HP:0200036)2.19177416
120Abnormal foot bone ossification (HP:0010675)2.18888210
121Decreased lacrimation (HP:0000633)2.17900327
122Abnormality of the acetabulum (HP:0003170)2.16041168
123Hepatocellular carcinoma (HP:0001402)2.14970061
124Mitral stenosis (HP:0001718)2.14707889
125Enlarged kidneys (HP:0000105)2.13783212
126Abnormality of endocrine pancreas physiology (HP:0012093)2.13685054
127Abnormality of the pancreatic islet cells (HP:0006476)2.13685054
128Gingival bleeding (HP:0000225)2.13588379
129Hypotelorism (HP:0000601)2.12979295
130Abnormality of pain sensation (HP:0010832)2.12852746
131Impaired pain sensation (HP:0007328)2.12852746
132Cardiovascular calcification (HP:0011915)2.10597944
133Increased serum pyruvate (HP:0003542)2.08168881
134Split hand (HP:0001171)2.07808625
135Amelogenesis imperfecta (HP:0000705)2.07363516
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06958986
137Hypoglycemic coma (HP:0001325)2.05806749
138Deep venous thrombosis (HP:0002625)2.05714602
139Hypoalphalipoproteinemia (HP:0003233)2.05293643
140Increased number of teeth (HP:0011069)2.05184657
141Cerebral aneurysm (HP:0004944)2.04943240
142Selective tooth agenesis (HP:0001592)2.03484004
143Conjugated hyperbilirubinemia (HP:0002908)2.03480489
144Abnormality of the labia minora (HP:0012880)2.02418342
145Bifid scrotum (HP:0000048)2.02343404
146Ketoacidosis (HP:0001993)2.00850849
147Popliteal pterygium (HP:0009756)2.00032850
148Gastrointestinal atresia (HP:0002589)1.99426518
149Widely patent fontanelles and sutures (HP:0004492)1.98989853
150Patellar aplasia (HP:0006443)1.98802405
151Malignant hyperthermia (HP:0002047)1.96818512
152Redundant skin (HP:0001582)1.96716351
153Bronchomalacia (HP:0002780)1.96074174
154IgA deficiency (HP:0002720)1.96047403
155Abnormality of the lacrimal duct (HP:0011481)1.94006418
156Hypolipoproteinemia (HP:0010981)1.93622811
157Narrow nasal bridge (HP:0000446)1.93262718
158Astrocytoma (HP:0009592)1.92659253
159Abnormality of the astrocytes (HP:0100707)1.92659253
160Cupped ribs (HP:0000887)1.92041596
161Nephroblastoma (Wilms tumor) (HP:0002667)1.91984045
162Generalized amyotrophy (HP:0003700)1.90311143
163Short 5th finger (HP:0009237)1.89599195
164Abnormality of the alveolar ridges (HP:0006477)1.87491692
165Hyperammonemia (HP:0001987)1.86050695
166Premature graying of hair (HP:0002216)1.85784949
167Potter facies (HP:0002009)1.84791471
168Facial shape deformation (HP:0011334)1.84791471
169Poikilocytosis (HP:0004447)1.81042421
170Heterotopia (HP:0002282)1.79573327
171Abnormality of the vitreous humor (HP:0004327)1.79342723
172Thrombophlebitis (HP:0004418)1.78792827
173Abnormality of the intrinsic pathway (HP:0010989)1.78307776
174Overlapping toe (HP:0001845)1.76670723
175Biconcave vertebral bodies (HP:0004586)1.74241531
176Embryonal renal neoplasm (HP:0011794)1.74111041
177Coxa vara (HP:0002812)1.71653376
178Supernumerary ribs (HP:0005815)1.71270368
179Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70692617
180Abnormality of the Achilles tendon (HP:0005109)1.68901069
181Fat malabsorption (HP:0002630)1.68771713
182Nasolacrimal duct obstruction (HP:0000579)1.67973318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.93489375
2ICK6.11492181
3MAPK155.47375900
4DDR25.38870073
5MAP3K64.51661940
6FGFR34.49181880
7WNK43.89061745
8MAP3K113.34744856
9PINK13.34538585
10EEF2K3.10238081
11TYRO33.10044885
12MATK3.01629633
13FGR2.92038496
14DAPK12.40622783
15BMX2.31282216
16UHMK12.25050638
17CSK2.24777077
18PRKD22.17293203
19PDGFRA2.10420663
20FGFR22.10232217
21DYRK1B2.07532440
22YES12.01839261
23PKN21.94884572
24PIM21.94264548
25AKT31.81006309
26CDK71.65998049
27WNK11.64471244
28CDK61.49762926
29LATS21.47336598
30SIK21.43702653
31SMG11.42976915
32TRPM71.40415060
33EIF2AK11.39021993
34NTRK31.33226605
35PIK3CA1.30028468
36MAPK111.24891410
37PIM11.23296065
38IRAK31.21329301
39GSK3A1.20637626
40RPS6KL11.20015714
41RPS6KC11.20015714
42NEK21.13548481
43CDC42BPA1.12985683
44RET1.12476264
45EPHA21.09990284
46PHKG21.07751358
47PHKG11.07751358
48MAP3K21.06795393
49PDPK11.04685387
50RPS6KA61.03152997
51STK391.00150532
52MAP3K100.97722750
53CHEK20.88127590
54ERBB20.85172165
55PTK60.83693200
56CDK120.78196866
57MAP3K70.76678851
58PRKAA10.73721668
59KSR20.73593856
60MTOR0.72783249
61DYRK30.72747933
62BCKDK0.72628547
63CSNK1E0.72596161
64PRPF4B0.69874226
65HIPK20.67822140
66TAOK20.67635908
67RPS6KA10.66054922
68PLK10.66034373
69CDK80.64927102
70PDK10.64846341
71LATS10.61284934
72MAP2K60.61077280
73SIK10.56805333
74TGFBR20.56296357
75BRSK10.56079773
76SGK2230.54440368
77SGK4940.54440368
78TRIB30.53689502
79BRD40.53539433
80NME10.52636371
81MAP2K30.50554624
82MST1R0.50032589
83EGFR0.48361460
84MARK20.46792692
85RPS6KB20.46076986
86CAMK2G0.46024138
87MELK0.45927758
88MAP3K90.44083765
89RAF10.42255144
90PRKAA20.41816274
91NEK90.41360116
92MAPK40.40794693
93SGK30.40629735
94RIPK10.40465742
95CAMK2B0.39245421
96CDK20.39162931
97CSNK1G10.38852042
98RPS6KB10.38080151
99TTK0.37937436
100CSNK2A10.37652673
101NTRK20.37302874
102PTK20.36772503
103ERBB30.36105384
104CAMK1D0.35980324
105MAP3K10.35571410
106PDGFRB0.35417899
107MAPK10.35374661
108MAPK30.35356217
109STK38L0.35322999
110ATR0.35194270
111STK30.35123433
112LMTK20.33662291
113LYN0.31686370
114PRKCZ0.30758146
115SCYL20.30701451
116SRPK10.29370452
117DYRK20.27409653
118INSR0.26946139
119MAPK100.26906943
120CSNK1D0.26224723
121STK380.26043793
122SRC0.25940873
123AURKA0.25705567
124EPHA40.25683555
125MAPK140.25533567
126TTN0.24653080
127CSNK2A20.24268813
128CAMK40.23975466
129TAOK10.21712988
130CAMK2A0.21406610
131TNK20.21079977
132ATM0.20735221
133SGK10.19754229
134CAMK2D0.19593888
135CDK150.19436318
136ERBB40.19021718
137GSK3B0.18872752
138CHEK10.18659830
139MAPKAPK30.18161191
140ALK0.18063823
141PRKACG0.17656619
142PAK20.17440142
143FLT30.17235247
144MET0.17098776
145RPS6KA30.16903892
146FGFR10.16640945
147CDK10.16490796
148CDK40.16046126
149PRKD10.15819388
150MAPKAPK20.14829668
151PRKCD0.14343921
152ERN10.13589240
153NEK10.13357460
154JAK20.12010213

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.23862945
2Mismatch repair_Homo sapiens_hsa034303.53891393
3Base excision repair_Homo sapiens_hsa034103.41631484
4Other glycan degradation_Homo sapiens_hsa005112.89668945
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71150520
6Arginine biosynthesis_Homo sapiens_hsa002202.64706959
7Arginine and proline metabolism_Homo sapiens_hsa003302.39156753
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36801329
9Vitamin digestion and absorption_Homo sapiens_hsa049772.32291553
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.31836307
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31126886
12DNA replication_Homo sapiens_hsa030302.28318198
13Fatty acid metabolism_Homo sapiens_hsa012122.26833695
14Vitamin B6 metabolism_Homo sapiens_hsa007502.16281359
15Biosynthesis of amino acids_Homo sapiens_hsa012302.12177133
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99335546
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96939995
18Folate biosynthesis_Homo sapiens_hsa007901.95399063
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81801396
20Sulfur relay system_Homo sapiens_hsa041221.80639735
21Nitrogen metabolism_Homo sapiens_hsa009101.75746600
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69384937
23Circadian rhythm_Homo sapiens_hsa047101.56879959
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54219820
25mTOR signaling pathway_Homo sapiens_hsa041501.53997135
26N-Glycan biosynthesis_Homo sapiens_hsa005101.53315259
27Hippo signaling pathway_Homo sapiens_hsa043901.51157142
28Hedgehog signaling pathway_Homo sapiens_hsa043401.51094310
29Lysine degradation_Homo sapiens_hsa003101.50482814
30Notch signaling pathway_Homo sapiens_hsa043301.49312005
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39879452
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.35917314
33Tryptophan metabolism_Homo sapiens_hsa003801.33525554
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32892370
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31817798
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27022828
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27004267
38Nucleotide excision repair_Homo sapiens_hsa034201.26978857
39Adherens junction_Homo sapiens_hsa045201.25359350
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20766450
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17047625
42Fructose and mannose metabolism_Homo sapiens_hsa000511.13645756
43mRNA surveillance pathway_Homo sapiens_hsa030151.12174780
44Bladder cancer_Homo sapiens_hsa052191.08853814
45Thyroid hormone synthesis_Homo sapiens_hsa049181.08630975
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07223404
47Steroid biosynthesis_Homo sapiens_hsa001001.05785776
48Complement and coagulation cascades_Homo sapiens_hsa046101.05107016
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04838997
50Selenocompound metabolism_Homo sapiens_hsa004501.04290924
51TGF-beta signaling pathway_Homo sapiens_hsa043501.03565801
52Renin-angiotensin system_Homo sapiens_hsa046141.02060671
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01078172
54Basal cell carcinoma_Homo sapiens_hsa052170.97081017
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.94855577
56Fatty acid degradation_Homo sapiens_hsa000710.93121554
57RNA transport_Homo sapiens_hsa030130.92944323
58Fatty acid elongation_Homo sapiens_hsa000620.89340092
59p53 signaling pathway_Homo sapiens_hsa041150.88470412
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87925874
61Spliceosome_Homo sapiens_hsa030400.87443578
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.87330565
63One carbon pool by folate_Homo sapiens_hsa006700.86619656
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84654901
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.84359535
66Fanconi anemia pathway_Homo sapiens_hsa034600.84140522
67Fat digestion and absorption_Homo sapiens_hsa049750.83768511
68Insulin resistance_Homo sapiens_hsa049310.81430497
69ECM-receptor interaction_Homo sapiens_hsa045120.78867094
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.78659034
71Glutathione metabolism_Homo sapiens_hsa004800.78225740
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77511658
73Homologous recombination_Homo sapiens_hsa034400.76894369
74Starch and sucrose metabolism_Homo sapiens_hsa005000.76633858
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76014044
76Propanoate metabolism_Homo sapiens_hsa006400.74100607
77Chemical carcinogenesis_Homo sapiens_hsa052040.73882631
78PPAR signaling pathway_Homo sapiens_hsa033200.73332369
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72910206
80Butanoate metabolism_Homo sapiens_hsa006500.71424960
81Glucagon signaling pathway_Homo sapiens_hsa049220.71047696
82beta-Alanine metabolism_Homo sapiens_hsa004100.70854514
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70399707
84Peroxisome_Homo sapiens_hsa041460.68890251
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68585546
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68520566
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68282120
88Prion diseases_Homo sapiens_hsa050200.68150336
89Bile secretion_Homo sapiens_hsa049760.67768050
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67601309
91Histidine metabolism_Homo sapiens_hsa003400.66834391
92Galactose metabolism_Homo sapiens_hsa000520.66371821
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.65969746
94Sphingolipid metabolism_Homo sapiens_hsa006000.64985088
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64035535
96Non-small cell lung cancer_Homo sapiens_hsa052230.61973733
97Pyruvate metabolism_Homo sapiens_hsa006200.56500640
98Pentose phosphate pathway_Homo sapiens_hsa000300.56179528
99Phenylalanine metabolism_Homo sapiens_hsa003600.55611590
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53992842
101Retinol metabolism_Homo sapiens_hsa008300.53975388
102Endometrial cancer_Homo sapiens_hsa052130.53081287
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.53072379
104ABC transporters_Homo sapiens_hsa020100.52463452
105HIF-1 signaling pathway_Homo sapiens_hsa040660.51714824
106Carbon metabolism_Homo sapiens_hsa012000.51708858
107VEGF signaling pathway_Homo sapiens_hsa043700.50904115
108* Wnt signaling pathway_Homo sapiens_hsa043100.49199473
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48544302
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.48477997
111AMPK signaling pathway_Homo sapiens_hsa041520.48388041
112Mineral absorption_Homo sapiens_hsa049780.47877237
113Staphylococcus aureus infection_Homo sapiens_hsa051500.47723665
114Shigellosis_Homo sapiens_hsa051310.47380599
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.47190714
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45059307
117Tight junction_Homo sapiens_hsa045300.42410302
118Glycerolipid metabolism_Homo sapiens_hsa005610.39701257
119Dorso-ventral axis formation_Homo sapiens_hsa043200.37652621
120Cell cycle_Homo sapiens_hsa041100.36900707
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36606595
122Colorectal cancer_Homo sapiens_hsa052100.35652244
123Tyrosine metabolism_Homo sapiens_hsa003500.33242952
124Pertussis_Homo sapiens_hsa051330.31924494
125Proteoglycans in cancer_Homo sapiens_hsa052050.31743259
126Chronic myeloid leukemia_Homo sapiens_hsa052200.30914576
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30887521
128Choline metabolism in cancer_Homo sapiens_hsa052310.30881748
129MicroRNAs in cancer_Homo sapiens_hsa052060.29811962
130Insulin signaling pathway_Homo sapiens_hsa049100.29319379
131Vibrio cholerae infection_Homo sapiens_hsa051100.27761344
132Metabolic pathways_Homo sapiens_hsa011000.26685006
133Caffeine metabolism_Homo sapiens_hsa002320.26078801
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24373707
135Oocyte meiosis_Homo sapiens_hsa041140.24265562
136Thyroid cancer_Homo sapiens_hsa052160.24087273
137Small cell lung cancer_Homo sapiens_hsa052220.24019696

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