ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.20603264
2	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	5.08851718
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.90799094
4	presynaptic membrane assembly (GO:0097105)	4.76851203
5	neurotransmitter-gated ion channel clustering (GO:0072578)	4.72960201
6	postsynaptic membrane organization (GO:0001941)	4.63153202
7	glutamine family amino acid biosynthetic process (GO:0009084)	4.58312613
8	cell wall macromolecule catabolic process (GO:0016998)	4.56621787
9	cell wall macromolecule metabolic process (GO:0044036)	4.56621787
10	vocalization behavior (GO:0071625)	4.31848332
11	primary amino compound metabolic process (GO:1901160)	4.22001100
12	cerebellar granule cell differentiation (GO:0021707)	4.11776312
13	presynaptic membrane organization (GO:0097090)	4.02109648
14	ATP hydrolysis coupled proton transport (GO:0015991)	3.97895063
15	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.97895063
16	mechanosensory behavior (GO:0007638)	3.84050653
17	regulation of synapse maturation (GO:0090128)	3.79599106
18	glutamate secretion (GO:0014047)	3.79284835
19	homocysteine metabolic process (GO:0050667)	3.75719190
20	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.75498863
21	positive regulation of fibroblast migration (GO:0010763)	3.69914298
22	protein localization to synapse (GO:0035418)	3.69873188
23	response to parathyroid hormone (GO:0071107)	3.64176747
24	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.63640748
25	neuron cell-cell adhesion (GO:0007158)	3.62573673
26	short-term memory (GO:0007614)	3.60563267
27	regulation of glutamate receptor signaling pathway (GO:1900449)	3.58341562
28	acrosome reaction (GO:0007340)	3.54951965
29	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.51975551
30	L-amino acid import (GO:0043092)	3.49800156
31	locomotory exploration behavior (GO:0035641)	3.49476471
32	auditory behavior (GO:0031223)	3.43979907
33	negative regulation of meiosis (GO:0045835)	3.42508651
34	* superoxide anion generation (GO:0042554)	3.42098336
35	* response to gravity (GO:0009629)	3.38599799
36	inositol phosphate-mediated signaling (GO:0048016)	3.37795325
37	intra-S DNA damage checkpoint (GO:0031573)	3.34845442
38	transferrin transport (GO:0033572)	3.34174721
39	Rac protein signal transduction (GO:0016601)	3.34078258
40	chondrocyte differentiation (GO:0002062)	3.32487102
41	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.31935242
42	organic cation transport (GO:0015695)	3.30886804
43	inner ear receptor cell development (GO:0060119)	3.27098632
44	calcium ion-dependent exocytosis (GO:0017156)	3.25121758
45	axonemal dynein complex assembly (GO:0070286)	3.24766826
46	cellular response to ammonium ion (GO:0071242)	3.22291679
47	regulation of synaptic vesicle exocytosis (GO:2000300)	3.15182675
48	cilium movement (GO:0003341)	3.13981390
49	positive regulation of smooth muscle cell migration (GO:0014911)	3.13529455
50	multicellular organism reproduction (GO:0032504)	3.13462157
51	phagosome maturation (GO:0090382)	3.13290144
52	serotonin metabolic process (GO:0042428)	3.11589809
53	ferric iron transport (GO:0015682)	3.11019433
54	trivalent inorganic cation transport (GO:0072512)	3.11019433
55	auditory receptor cell stereocilium organization (GO:0060088)	3.10952399
56	sperm motility (GO:0030317)	3.10522965
57	response to histamine (GO:0034776)	3.08765055
58	positive regulation of synapse maturation (GO:0090129)	3.06133690
59	positive regulation of DNA biosynthetic process (GO:2000573)	3.05330896
60	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.00896673
61	neuron maturation (GO:0042551)	2.99927905
62	response to auditory stimulus (GO:0010996)	2.99897140
63	startle response (GO:0001964)	2.98681062
64	keratan sulfate catabolic process (GO:0042340)	2.96661353
65	G-protein coupled receptor internalization (GO:0002031)	2.96203005
66	piRNA metabolic process (GO:0034587)	2.94181341
67	bone trabecula formation (GO:0060346)	2.94059274
68	mitochondrion distribution (GO:0048311)	2.92911851
69	protein K11-linked deubiquitination (GO:0035871)	2.91567450
70	acrosome assembly (GO:0001675)	2.89526567
71	detection of calcium ion (GO:0005513)	2.85789858
72	neurotransmitter uptake (GO:0001504)	2.85758586
73	glutamine metabolic process (GO:0006541)	2.81876736
74	cellular response to gamma radiation (GO:0071480)	2.80217342
75	reflex (GO:0060004)	2.79444360
76	chondrocyte development (GO:0002063)	2.78632858
77	glycine transport (GO:0015816)	2.77276947
78	behavioral response to ethanol (GO:0048149)	2.73956077
79	neuronal action potential propagation (GO:0019227)	2.73799716
80	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.72465365
81	reproduction (GO:0000003)	2.71962210
82	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.71051583
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.69831276
84	negative regulation of amino acid transport (GO:0051956)	2.67982309
85	positive regulation of extracellular matrix organization (GO:1903055)	2.67895867
86	uterus development (GO:0060065)	2.67252502
87	sleep (GO:0030431)	2.65995605
88	exploration behavior (GO:0035640)	2.64113228
89	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.63124736
90	regulation of neurotransmitter secretion (GO:0046928)	2.60061618
91	regulation of synaptic vesicle transport (GO:1902803)	2.59691987
92	C4-dicarboxylate transport (GO:0015740)	2.57916909
93	neuron-neuron synaptic transmission (GO:0007270)	2.55262297
94	skeletal muscle fiber development (GO:0048741)	2.54739909
95	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.53793670
96	cartilage condensation (GO:0001502)	2.52608033
97	cell aggregation (GO:0098743)	2.52608033
98	negative regulation of meiotic cell cycle (GO:0051447)	2.52259935
99	positive regulation of neurotransmitter secretion (GO:0001956)	2.50903768
100	synaptic vesicle exocytosis (GO:0016079)	2.50519240

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.13754635
2	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.53078160
3	* ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47459644
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.40102916
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27874002
6	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.21745891
7	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.19286390
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.17393006
9	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.15688543
10	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.15634562
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.15489741
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.13982980
13	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.05578149
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.04642695
15	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.02725228
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.99104178
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.98480763
18	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.94012228
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89874228
20	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.87172661
21	HTT_18923047_ChIP-ChIP_STHdh_Human	1.85224690
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85064668
23	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.82719767
24	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.82719767
25	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.81512371
26	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.81181241
27	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80897742
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.79495752
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.78363374
30	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.78146896
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.77776142
32	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.77441500
33	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.77059876
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.76515972
35	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.73974803
36	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.72736993
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71863107
38	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.70682053
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70132269
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69097016
41	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.68048280
42	P300_19829295_ChIP-Seq_ESCs_Human	1.67663712
43	P53_22387025_ChIP-Seq_ESCs_Mouse	1.67622615
44	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.64765785
45	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.64246637
46	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.62464549
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62430496
48	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.59779184
49	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.58487508
50	DROSHA_22980978_ChIP-Seq_HELA_Human	1.55235582
51	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.55014658
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53842642
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53842642
54	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.53213828
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.52355089
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52179273
57	AR_21572438_ChIP-Seq_LNCaP_Human	1.49018296
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.47359712
59	P300_18555785_Chip-Seq_ESCs_Mouse	1.47137609
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.46682412
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45270429
62	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.44640877
63	PU1_27457419_Chip-Seq_LIVER_Mouse	1.43352508
64	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.41585971
65	TP53_18474530_ChIP-ChIP_U2OS_Human	1.41057133
66	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.39043393
67	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.37300162
68	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.36678398
69	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34991241
70	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.33813403
71	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.32217048
72	FUS_26573619_Chip-Seq_HEK293_Human	1.31899140
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31015970
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30304368
75	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.29493290
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.29412727
77	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.29029699
78	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28980122
79	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.28961252
80	* STAT3_23295773_ChIP-Seq_U87_Human	1.26249648
81	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.25922446
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21828816
83	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20365765
84	* KDM2B_26808549_Chip-Seq_REH_Human	1.18421404
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18395403
86	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17335825
87	TAF15_26573619_Chip-Seq_HEK293_Human	1.16932434
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.16922816
89	TCF4_23295773_ChIP-Seq_U87_Human	1.16887000
90	* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13870433
91	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10648966
92	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.08648436
93	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.08454899
94	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07829850
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07302375
96	AR_25329375_ChIP-Seq_VCAP_Human	1.05569583
97	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02309980
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01794998
99	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00047719
100	* CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98618772

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.42541500
2	MP0005257_abnormal_intraocular_pressure	3.37038666
3	MP0002735_abnormal_chemical_nociception	3.25443552
4	MP0002876_abnormal_thyroid_physiology	2.99016459
5	MP0005410_abnormal_fertilization	2.97542887
6	MP0003880_abnormal_central_pattern	2.92542737
7	MP0002736_abnormal_nociception_after	2.78320628
8	MP0004859_abnormal_synaptic_plasticity	2.66431874
9	MP0001968_abnormal_touch/_nociception	2.56017674
10	MP0003195_calcinosis	2.46545942
11	MP0004484_altered_response_of	2.44437987
12	MP0002163_abnormal_gland_morphology	2.43759722
13	MP0005645_abnormal_hypothalamus_physiol	2.42210619
14	MP0001440_abnormal_grooming_behavior	2.39841311
15	MP0005503_abnormal_tendon_morphology	2.39277095
16	MP0002102_abnormal_ear_morphology	2.30885646
17	MP0001486_abnormal_startle_reflex	2.24675218
18	MP0003879_abnormal_hair_cell	2.24379885
19	MP0006276_abnormal_autonomic_nervous	2.22051827
20	MP0002909_abnormal_adrenal_gland	2.20454247
21	MP0002734_abnormal_mechanical_nocicepti	2.18019154
22	MP0009745_abnormal_behavioral_response	2.14060600
23	MP0009046_muscle_twitch	2.12390872
24	MP0005646_abnormal_pituitary_gland	2.10829468
25	MP0003635_abnormal_synaptic_transmissio	2.08839912
26	MP0009697_abnormal_copulation	2.03512426
27	MP0009780_abnormal_chondrocyte_physiolo	1.98141717
28	MP0004134_abnormal_chest_morphology	1.97091104
29	MP0005623_abnormal_meninges_morphology	1.97022475
30	MP0002063_abnormal_learning/memory/cond	1.93138394
31	MP0003787_abnormal_imprinting	1.92343582
32	MP0003123_paternal_imprinting	1.91767645
33	MP0001501_abnormal_sleep_pattern	1.90737760
34	MP0002572_abnormal_emotion/affect_behav	1.81190287
35	MP0001963_abnormal_hearing_physiology	1.81002716
36	MP0002282_abnormal_trachea_morphology	1.80176750
37	MP0008260_abnormal_autophagy	1.71667517
38	MP0002933_joint_inflammation	1.71112686
39	MP0005379_endocrine/exocrine_gland_phen	1.70500347
40	MP0003283_abnormal_digestive_organ	1.68824002
41	* MP0002067_abnormal_sensory_capabilities	1.61994234
42	MP0002064_seizures	1.56835811
43	MP0005451_abnormal_body_composition	1.55516605
44	MP0002733_abnormal_thermal_nociception	1.55417436
45	MP0002184_abnormal_innervation	1.55100125
46	MP0002557_abnormal_social/conspecific_i	1.52772200
47	MP0001188_hyperpigmentation	1.50323177
48	MP0002272_abnormal_nervous_system	1.49463356
49	MP0003122_maternal_imprinting	1.48898265
50	MP0000383_abnormal_hair_follicle	1.42876795
51	MP0000751_myopathy	1.42855904
52	MP0001970_abnormal_pain_threshold	1.42794176
53	* MP0004742_abnormal_vestibular_system	1.37041705
54	MP0010386_abnormal_urinary_bladder	1.34803594
55	MP0001346_abnormal_lacrimal_gland	1.33687179
56	MP0004270_analgesia	1.26670201
57	* MP0000026_abnormal_inner_ear	1.25745579
58	MP0003941_abnormal_skin_development	1.19607633
59	MP0005165_increased_susceptibility_to	1.19580251
60	MP0000163_abnormal_cartilage_morphology	1.16018847
61	MP0002089_abnormal_postnatal_growth/wei	1.12225001
62	MP0008438_abnormal_cutaneous_collagen	1.12018251
63	MP0009384_cardiac_valve_regurgitation	1.09546822
64	MP0003183_abnormal_peptide_metabolism	1.08333337
65	MP0001905_abnormal_dopamine_level	1.05296836
66	MP0000427_abnormal_hair_cycle	1.03576124
67	MP0003698_abnormal_male_reproductive	1.00415764
68	MP0009764_decreased_sensitivity_to	0.93686785
69	MP0008877_abnormal_DNA_methylation	0.93502730
70	MP0002115_abnormal_skeleton_extremities	0.92699812
71	MP0009250_abnormal_appendicular_skeleto	0.90071013
72	MP0002108_abnormal_muscle_morphology	0.89633710
73	MP0000343_altered_response_to	0.87865387
74	MP0003868_abnormal_feces_composition	0.87863558
75	MP0004142_abnormal_muscle_tone	0.87611614
76	MP0008004_abnormal_stomach_pH	0.87206603
77	MP0008874_decreased_physiological_sensi	0.85441151
78	MP0010678_abnormal_skin_adnexa	0.85214542
79	MP0002896_abnormal_bone_mineralization	0.78561895
80	MP0005647_abnormal_sex_gland	0.76637099
81	* MP0002066_abnormal_motor_capabilities/c	0.75634998
82	MP0001299_abnormal_eye_distance/	0.74648166
83	MP0005508_abnormal_skeleton_morphology	0.71511618
84	MP0003566_abnormal_cell_adhesion	0.71057159
85	* MP0001502_abnormal_circadian_rhythm	0.70884389
86	MP0003121_genomic_imprinting	0.70432960
87	MP0002113_abnormal_skeleton_development	0.70191983
88	MP0010030_abnormal_orbit_morphology	0.68964664
89	MP0005166_decreased_susceptibility_to	0.67557798
90	MP0004858_abnormal_nervous_system	0.67536395
91	MP0005171_absent_coat_pigmentation	0.67066037
92	MP0000762_abnormal_tongue_morphology	0.66939769
93	MP0001485_abnormal_pinna_reflex	0.65662820
94	MP0001929_abnormal_gametogenesis	0.65362549
95	MP0001727_abnormal_embryo_implantation	0.63941145
96	MP0003633_abnormal_nervous_system	0.60728485
97	MP0003011_delayed_dark_adaptation	0.60116692
98	MP0004782_abnormal_surfactant_physiolog	0.59236715
99	MP0005390_skeleton_phenotype	0.58351607
100	MP0000579_abnormal_nail_morphology	0.57938958

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Epiphyseal dysplasia (HP:0002656)	6.82121729
2	Mesomelia (HP:0003027)	6.28004853
3	Irregular epiphyses (HP:0010582)	5.92277147
4	Focal motor seizures (HP:0011153)	5.74090652
5	Vitreoretinal degeneration (HP:0000655)	4.80158709
6	Small epiphyses (HP:0010585)	4.79152034
7	Abnormal ciliary motility (HP:0012262)	4.63735386
8	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	4.19815514
9	Abnormal tarsal ossification (HP:0008369)	4.00583590
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.97927380
11	Neonatal short-limb short stature (HP:0008921)	3.88248463
12	Hyperventilation (HP:0002883)	3.83638925
13	Hypoplastic ischia (HP:0003175)	3.80923899
14	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	3.79413184
15	Absent epiphyses (HP:0010577)	3.79413184
16	Short femoral neck (HP:0100864)	3.70565094
17	Abnormality of the vertebral endplates (HP:0005106)	3.67786044
18	Epileptic encephalopathy (HP:0200134)	3.56338983
19	Abnormality of the ischium (HP:0003174)	3.45307059
20	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	3.40365090
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.30829623
22	Absent/shortened dynein arms (HP:0200106)	3.30829623
23	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	3.24482691
24	Abnormality of femoral epiphyses (HP:0006499)	3.24482691
25	Febrile seizures (HP:0002373)	3.23496907
26	Abnormality of the epiphysis of the femoral head (HP:0010574)	3.05964288
27	Cupped ribs (HP:0000887)	3.04475402
28	Elevated erythrocyte sedimentation rate (HP:0003565)	3.04388835
29	Flattened epiphyses (HP:0003071)	3.01455395
30	Genu varum (HP:0002970)	2.97899621
31	Flat capital femoral epiphysis (HP:0003370)	2.97083687
32	Abnormality of the femoral head (HP:0003368)	2.84934334
33	Osteoarthritis (HP:0002758)	2.83142429
34	Akinesia (HP:0002304)	2.79342451
35	Mild short stature (HP:0003502)	2.77969992
36	Arthropathy (HP:0003040)	2.70944345
37	Metaphyseal irregularity (HP:0003025)	2.70317057
38	Irregular vertebral endplates (HP:0003301)	2.69938145
39	Split foot (HP:0001839)	2.68749480
40	Oligodactyly (hands) (HP:0001180)	2.68293367
41	Delayed epiphyseal ossification (HP:0002663)	2.66963527
42	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.66725878
43	Infertility (HP:0000789)	2.63983168
44	Neonatal hypoglycemia (HP:0001998)	2.56688128
45	Ovoid vertebral bodies (HP:0003300)	2.49148607
46	Aplasia/hypoplasia of the femur (HP:0005613)	2.47937183
47	Focal seizures (HP:0007359)	2.45117385
48	Hypoplasia of the odontoid process (HP:0003311)	2.45052778
49	Lower limb amyotrophy (HP:0007210)	2.44483508
50	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.41520749
51	Generalized tonic-clonic seizures (HP:0002069)	2.38164250
52	Abnormality of the pubic bones (HP:0003172)	2.37129241
53	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	2.36992723
54	Broad-based gait (HP:0002136)	2.34851547
55	Long clavicles (HP:0000890)	2.34846896
56	Abnormal foot bone ossification (HP:0010675)	2.34324170
57	Short thorax (HP:0010306)	2.34284182
58	Atonic seizures (HP:0010819)	2.32508829
59	Severe Myopia (HP:0011003)	2.29676514
60	Flat acetabular roof (HP:0003180)	2.29070669
61	Broad palm (HP:0001169)	2.23311756
62	Absence seizures (HP:0002121)	2.23271936
63	Resting tremor (HP:0002322)	2.22586696
64	Postural instability (HP:0002172)	2.20282757
65	Coxa vara (HP:0002812)	2.18916134
66	Barrel-shaped chest (HP:0001552)	2.18360399
67	Distal lower limb muscle weakness (HP:0009053)	2.13698561
68	Abnormality of carpal bone ossification (HP:0006257)	2.12690738
69	Joint stiffness (HP:0001387)	2.12097737
70	Dialeptic seizures (HP:0011146)	2.11314782
71	Micromelia (HP:0002983)	2.11310844
72	Vascular calcification (HP:0004934)	2.07616546
73	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06124842
74	Abnormal respiratory epithelium morphology (HP:0012253)	2.06124842
75	Spinal cord compression (HP:0002176)	2.05569500
76	Rhizomelia (HP:0008905)	2.05142422
77	Limited hip movement (HP:0008800)	2.03482447
78	Myositis (HP:0100614)	2.02544074
79	Thyroid-stimulating hormone excess (HP:0002925)	2.02162654
80	Abnormality of the odontoid process (HP:0003310)	2.01631656
81	Hyperphosphatemia (HP:0002905)	2.01586160
82	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.01088090
83	Relative macrocephaly (HP:0004482)	2.00759228
84	Interstitial pulmonary disease (HP:0006530)	2.00196589
85	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.99434875
86	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.97243016
87	Submucous cleft hard palate (HP:0000176)	1.97127038
88	Prostate neoplasm (HP:0100787)	1.96931736
89	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.95613151
90	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.94677147
91	Abnormal gallbladder physiology (HP:0012438)	1.92347591
92	Cholecystitis (HP:0001082)	1.92347591
93	Waddling gait (HP:0002515)	1.92240082
94	Distal lower limb amyotrophy (HP:0008944)	1.92219987
95	Cardiovascular calcification (HP:0011915)	1.89135945
96	Disproportionate short-trunk short stature (HP:0003521)	1.87614612
97	Azoospermia (HP:0000027)	1.87457483
98	Abnormal spermatogenesis (HP:0008669)	1.86190852
99	Fetal akinesia sequence (HP:0001989)	1.85655230
100	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.83094656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	8.88704366
2	DAPK2	4.86369927
3	CDK19	4.14175702
4	OXSR1	2.55156224
5	NTRK3	2.51189831
6	AKT3	2.34520436
7	MAP2K7	2.17933780
8	EPHA4	2.15778952
9	DAPK1	2.13703443
10	SIK3	2.12275713
11	STK38L	1.99396751
12	BCR	1.77239070
13	NME1	1.72000022
14	MAP3K3	1.66586071
15	MAP3K4	1.60621411
16	EIF2AK2	1.39252298
17	CAMKK2	1.36111252
18	PLK2	1.32484375
19	TNIK	1.23864657
20	STK24	1.23152162
21	EIF2AK3	1.22862988
22	DAPK3	1.20663872
23	INSRR	1.15929993
24	DDR2	1.15199672
25	PRKCG	1.14646244
26	CAMK2A	1.13593838
27	STK11	1.09200336
28	TNK2	1.07782680
29	TBK1	1.06728217
30	PRKD3	1.03100213
31	ICK	0.99834161
32	FGR	0.95110860
33	MUSK	0.94351203
34	PINK1	0.93643306
35	FES	0.87620832
36	ADRBK2	0.86488515
37	SIK1	0.85729827
38	STK3	0.85719453
39	MAP2K4	0.84003290
40	MOS	0.83594752
41	SIK2	0.83064737
42	MAP3K6	0.81190940
43	CAMKK1	0.80214930
44	SGK223	0.74927558
45	SGK494	0.74927558
46	SGK2	0.73687721
47	CDK5	0.73644089
48	PDK1	0.71835513
49	LATS1	0.71038563
50	PRKCE	0.69971786
51	PDK3	0.68736572
52	PDK4	0.68736572
53	MAPK7	0.66615935
54	PRKG2	0.64823954
55	PDPK1	0.64205288
56	BRAF	0.64088739
57	BMPR2	0.63503804
58	PRPF4B	0.63063540
59	FGFR1	0.62440677
60	GRK5	0.58245657
61	JAK1	0.57339082
62	FER	0.54263553
63	MAP3K9	0.53359262
64	PTK2B	0.53261900
65	MAP3K13	0.52094792
66	STK39	0.50941866
67	ADRBK1	0.50372404
68	MAP3K14	0.49381655
69	LATS2	0.48755453
70	DYRK1A	0.47378132
71	SGK3	0.46822355
72	MAPK4	0.44922466
73	PDK2	0.43887089
74	CDK18	0.43274628
75	CAMK4	0.43087080
76	AKT2	0.42966029
77	SGK1	0.42763990
78	CDK3	0.40126339
79	CAMK2B	0.39901156
80	CDK15	0.37779308
81	MKNK2	0.35776305
82	NTRK2	0.35449108
83	PRKACA	0.35408506
84	PRKCD	0.34657167
85	PRKCA	0.33959231
86	ERBB4	0.33817019
87	MARK1	0.32994600
88	TRPM7	0.32315778
89	GRK1	0.32190502
90	MAP3K12	0.30573710
91	MAPK12	0.29860078
92	CCNB1	0.28147657
93	CDK14	0.27746231
94	CDK11A	0.26051396
95	PRKG1	0.25675756
96	CAMK1	0.23926393
97	CDK8	0.23896219
98	PRKACG	0.23848393
99	PRKCB	0.23755344
100	MAPK13	0.23738996

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Collecting duct acid secretion_Homo sapiens_hsa04966	4.22495050
2	Nicotine addiction_Homo sapiens_hsa05033	4.01614935
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.48504628
4	Morphine addiction_Homo sapiens_hsa05032	2.48841871
5	Vibrio cholerae infection_Homo sapiens_hsa05110	2.42384235
6	Insulin secretion_Homo sapiens_hsa04911	2.24758491
7	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.22442621
8	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	2.08339938
9	Salivary secretion_Homo sapiens_hsa04970	2.07024215
10	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.00313176
11	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.94615984
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.93152814
13	Olfactory transduction_Homo sapiens_hsa04740	1.83556002
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.76176720
15	Propanoate metabolism_Homo sapiens_hsa00640	1.75816361
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74087317
17	Circadian entrainment_Homo sapiens_hsa04713	1.73495324
18	GABAergic synapse_Homo sapiens_hsa04727	1.71527652
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.68006595
20	Amphetamine addiction_Homo sapiens_hsa05031	1.52467079
21	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.44421684
22	* Phagosome_Homo sapiens_hsa04145	1.41138327
23	ECM-receptor interaction_Homo sapiens_hsa04512	1.40302780
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.35179922
25	Taste transduction_Homo sapiens_hsa04742	1.35029857
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33392726
27	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.19512887
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.15888904
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.13485863
30	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.13189392
31	Protein digestion and absorption_Homo sapiens_hsa04974	1.10910493
32	Renin secretion_Homo sapiens_hsa04924	1.08605362
33	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08149041
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05096102
35	Ether lipid metabolism_Homo sapiens_hsa00565	0.98767012
36	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93059842
37	Long-term potentiation_Homo sapiens_hsa04720	0.92941937
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92891012
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90453676
40	cAMP signaling pathway_Homo sapiens_hsa04024	0.90220197
41	Serotonergic synapse_Homo sapiens_hsa04726	0.88036249
42	Cocaine addiction_Homo sapiens_hsa05030	0.87245260
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84242811
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82933542
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82485356
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79919243
47	Histidine metabolism_Homo sapiens_hsa00340	0.79896515
48	Axon guidance_Homo sapiens_hsa04360	0.78262732
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.78203834
50	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75764602
51	Allograft rejection_Homo sapiens_hsa05330	0.74794105
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74155675
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73158985
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72992269
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72337098
56	African trypanosomiasis_Homo sapiens_hsa05143	0.72136667
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.70609290
58	Cholinergic synapse_Homo sapiens_hsa04725	0.69131911
59	Malaria_Homo sapiens_hsa05144	0.67477508
60	Amoebiasis_Homo sapiens_hsa05146	0.67053684
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66504526
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.64987150
63	Long-term depression_Homo sapiens_hsa04730	0.64922798
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63883717
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62697706
66	Circadian rhythm_Homo sapiens_hsa04710	0.61647387
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60112997
68	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.60008694
69	Gastric acid secretion_Homo sapiens_hsa04971	0.59973614
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59829534
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59130753
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.56681349
73	Bile secretion_Homo sapiens_hsa04976	0.54184200
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.53058151
75	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51603142
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.50380214
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.50023642
78	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.48779364
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48454976
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47092842
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45322301
82	Ras signaling pathway_Homo sapiens_hsa04014	0.44545023
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42669607
84	Gap junction_Homo sapiens_hsa04540	0.42460132
85	Retinol metabolism_Homo sapiens_hsa00830	0.41982139
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41743504
87	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.41211776
88	Arginine biosynthesis_Homo sapiens_hsa00220	0.40677775
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.37690923
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36398454
91	Fatty acid degradation_Homo sapiens_hsa00071	0.33662180
92	Phototransduction_Homo sapiens_hsa04744	0.32842399
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.31812668
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30868518
95	Pancreatic secretion_Homo sapiens_hsa04972	0.30574431
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30258020
97	TNF signaling pathway_Homo sapiens_hsa04668	0.29717338
98	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.29559157
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28388987
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.27256928

NOX3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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