NOX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.20603264
2regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.08851718
3detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.90799094
4presynaptic membrane assembly (GO:0097105)4.76851203
5neurotransmitter-gated ion channel clustering (GO:0072578)4.72960201
6postsynaptic membrane organization (GO:0001941)4.63153202
7glutamine family amino acid biosynthetic process (GO:0009084)4.58312613
8cell wall macromolecule catabolic process (GO:0016998)4.56621787
9cell wall macromolecule metabolic process (GO:0044036)4.56621787
10vocalization behavior (GO:0071625)4.31848332
11primary amino compound metabolic process (GO:1901160)4.22001100
12cerebellar granule cell differentiation (GO:0021707)4.11776312
13presynaptic membrane organization (GO:0097090)4.02109648
14ATP hydrolysis coupled proton transport (GO:0015991)3.97895063
15energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.97895063
16mechanosensory behavior (GO:0007638)3.84050653
17regulation of synapse maturation (GO:0090128)3.79599106
18glutamate secretion (GO:0014047)3.79284835
19homocysteine metabolic process (GO:0050667)3.75719190
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75498863
21positive regulation of fibroblast migration (GO:0010763)3.69914298
22protein localization to synapse (GO:0035418)3.69873188
23response to parathyroid hormone (GO:0071107)3.64176747
24detection of mechanical stimulus involved in sensory perception (GO:0050974)3.63640748
25neuron cell-cell adhesion (GO:0007158)3.62573673
26short-term memory (GO:0007614)3.60563267
27regulation of glutamate receptor signaling pathway (GO:1900449)3.58341562
28acrosome reaction (GO:0007340)3.54951965
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51975551
30L-amino acid import (GO:0043092)3.49800156
31locomotory exploration behavior (GO:0035641)3.49476471
32auditory behavior (GO:0031223)3.43979907
33negative regulation of meiosis (GO:0045835)3.42508651
34* superoxide anion generation (GO:0042554)3.42098336
35* response to gravity (GO:0009629)3.38599799
36inositol phosphate-mediated signaling (GO:0048016)3.37795325
37intra-S DNA damage checkpoint (GO:0031573)3.34845442
38transferrin transport (GO:0033572)3.34174721
39Rac protein signal transduction (GO:0016601)3.34078258
40chondrocyte differentiation (GO:0002062)3.32487102
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.31935242
42organic cation transport (GO:0015695)3.30886804
43inner ear receptor cell development (GO:0060119)3.27098632
44calcium ion-dependent exocytosis (GO:0017156)3.25121758
45axonemal dynein complex assembly (GO:0070286)3.24766826
46cellular response to ammonium ion (GO:0071242)3.22291679
47regulation of synaptic vesicle exocytosis (GO:2000300)3.15182675
48cilium movement (GO:0003341)3.13981390
49positive regulation of smooth muscle cell migration (GO:0014911)3.13529455
50multicellular organism reproduction (GO:0032504)3.13462157
51phagosome maturation (GO:0090382)3.13290144
52serotonin metabolic process (GO:0042428)3.11589809
53ferric iron transport (GO:0015682)3.11019433
54trivalent inorganic cation transport (GO:0072512)3.11019433
55auditory receptor cell stereocilium organization (GO:0060088)3.10952399
56sperm motility (GO:0030317)3.10522965
57response to histamine (GO:0034776)3.08765055
58positive regulation of synapse maturation (GO:0090129)3.06133690
59positive regulation of DNA biosynthetic process (GO:2000573)3.05330896
60regulation of non-canonical Wnt signaling pathway (GO:2000050)3.00896673
61neuron maturation (GO:0042551)2.99927905
62response to auditory stimulus (GO:0010996)2.99897140
63startle response (GO:0001964)2.98681062
64keratan sulfate catabolic process (GO:0042340)2.96661353
65G-protein coupled receptor internalization (GO:0002031)2.96203005
66piRNA metabolic process (GO:0034587)2.94181341
67bone trabecula formation (GO:0060346)2.94059274
68mitochondrion distribution (GO:0048311)2.92911851
69protein K11-linked deubiquitination (GO:0035871)2.91567450
70acrosome assembly (GO:0001675)2.89526567
71detection of calcium ion (GO:0005513)2.85789858
72neurotransmitter uptake (GO:0001504)2.85758586
73glutamine metabolic process (GO:0006541)2.81876736
74cellular response to gamma radiation (GO:0071480)2.80217342
75reflex (GO:0060004)2.79444360
76chondrocyte development (GO:0002063)2.78632858
77glycine transport (GO:0015816)2.77276947
78behavioral response to ethanol (GO:0048149)2.73956077
79neuronal action potential propagation (GO:0019227)2.73799716
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72465365
81reproduction (GO:0000003)2.71962210
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71051583
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69831276
84negative regulation of amino acid transport (GO:0051956)2.67982309
85positive regulation of extracellular matrix organization (GO:1903055)2.67895867
86uterus development (GO:0060065)2.67252502
87sleep (GO:0030431)2.65995605
88exploration behavior (GO:0035640)2.64113228
89negative regulation of homotypic cell-cell adhesion (GO:0034111)2.63124736
90regulation of neurotransmitter secretion (GO:0046928)2.60061618
91regulation of synaptic vesicle transport (GO:1902803)2.59691987
92C4-dicarboxylate transport (GO:0015740)2.57916909
93neuron-neuron synaptic transmission (GO:0007270)2.55262297
94skeletal muscle fiber development (GO:0048741)2.54739909
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.53793670
96cartilage condensation (GO:0001502)2.52608033
97cell aggregation (GO:0098743)2.52608033
98negative regulation of meiotic cell cycle (GO:0051447)2.52259935
99positive regulation of neurotransmitter secretion (GO:0001956)2.50903768
100synaptic vesicle exocytosis (GO:0016079)2.50519240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.13754635
2PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53078160
3* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47459644
4EZH2_22144423_ChIP-Seq_EOC_Human2.40102916
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.27874002
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21745891
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19286390
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.17393006
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15688543
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15634562
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.15489741
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.13982980
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05578149
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.04642695
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.02725228
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99104178
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98480763
18EZH2_27294783_Chip-Seq_NPCs_Mouse1.94012228
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89874228
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87172661
21HTT_18923047_ChIP-ChIP_STHdh_Human1.85224690
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85064668
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82719767
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82719767
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.81512371
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81181241
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80897742
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79495752
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78363374
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78146896
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.77776142
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77441500
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77059876
34REST_21632747_ChIP-Seq_MESCs_Mouse1.76515972
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.73974803
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.72736993
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71863107
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70682053
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70132269
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.69097016
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68048280
42P300_19829295_ChIP-Seq_ESCs_Human1.67663712
43P53_22387025_ChIP-Seq_ESCs_Mouse1.67622615
44CMYC_18555785_Chip-Seq_ESCs_Mouse1.64765785
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.64246637
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.62464549
47SMAD4_21799915_ChIP-Seq_A2780_Human1.62430496
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.59779184
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.58487508
50DROSHA_22980978_ChIP-Seq_HELA_Human1.55235582
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55014658
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53842642
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53842642
54OCT4_21477851_ChIP-Seq_ESCs_Mouse1.53213828
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.52355089
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52179273
57AR_21572438_ChIP-Seq_LNCaP_Human1.49018296
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.47359712
59P300_18555785_Chip-Seq_ESCs_Mouse1.47137609
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46682412
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.45270429
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.44640877
63PU1_27457419_Chip-Seq_LIVER_Mouse1.43352508
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.41585971
65TP53_18474530_ChIP-ChIP_U2OS_Human1.41057133
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.39043393
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37300162
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.36678398
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34991241
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.33813403
71CTCF_18555785_Chip-Seq_ESCs_Mouse1.32217048
72FUS_26573619_Chip-Seq_HEK293_Human1.31899140
73RNF2_27304074_Chip-Seq_NSC_Mouse1.31015970
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30304368
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29493290
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29412727
77SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29029699
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28980122
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.28961252
80* STAT3_23295773_ChIP-Seq_U87_Human1.26249648
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.25922446
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21828816
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20365765
84* KDM2B_26808549_Chip-Seq_REH_Human1.18421404
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18395403
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17335825
87TAF15_26573619_Chip-Seq_HEK293_Human1.16932434
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16922816
89TCF4_23295773_ChIP-Seq_U87_Human1.16887000
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13870433
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10648966
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08648436
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08454899
94* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07829850
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07302375
96AR_25329375_ChIP-Seq_VCAP_Human1.05569583
97RUNX2_22187159_ChIP-Seq_PCA_Human1.02309980
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01794998
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00047719
100* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98618772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.42541500
2MP0005257_abnormal_intraocular_pressure3.37038666
3MP0002735_abnormal_chemical_nociception3.25443552
4MP0002876_abnormal_thyroid_physiology2.99016459
5MP0005410_abnormal_fertilization2.97542887
6MP0003880_abnormal_central_pattern2.92542737
7MP0002736_abnormal_nociception_after2.78320628
8MP0004859_abnormal_synaptic_plasticity2.66431874
9MP0001968_abnormal_touch/_nociception2.56017674
10MP0003195_calcinosis2.46545942
11MP0004484_altered_response_of2.44437987
12MP0002163_abnormal_gland_morphology2.43759722
13MP0005645_abnormal_hypothalamus_physiol2.42210619
14MP0001440_abnormal_grooming_behavior2.39841311
15MP0005503_abnormal_tendon_morphology2.39277095
16MP0002102_abnormal_ear_morphology2.30885646
17MP0001486_abnormal_startle_reflex2.24675218
18MP0003879_abnormal_hair_cell2.24379885
19MP0006276_abnormal_autonomic_nervous2.22051827
20MP0002909_abnormal_adrenal_gland2.20454247
21MP0002734_abnormal_mechanical_nocicepti2.18019154
22MP0009745_abnormal_behavioral_response2.14060600
23MP0009046_muscle_twitch2.12390872
24MP0005646_abnormal_pituitary_gland2.10829468
25MP0003635_abnormal_synaptic_transmissio2.08839912
26MP0009697_abnormal_copulation2.03512426
27MP0009780_abnormal_chondrocyte_physiolo1.98141717
28MP0004134_abnormal_chest_morphology1.97091104
29MP0005623_abnormal_meninges_morphology1.97022475
30MP0002063_abnormal_learning/memory/cond1.93138394
31MP0003787_abnormal_imprinting1.92343582
32MP0003123_paternal_imprinting1.91767645
33MP0001501_abnormal_sleep_pattern1.90737760
34MP0002572_abnormal_emotion/affect_behav1.81190287
35MP0001963_abnormal_hearing_physiology1.81002716
36MP0002282_abnormal_trachea_morphology1.80176750
37MP0008260_abnormal_autophagy1.71667517
38MP0002933_joint_inflammation1.71112686
39MP0005379_endocrine/exocrine_gland_phen1.70500347
40MP0003283_abnormal_digestive_organ1.68824002
41* MP0002067_abnormal_sensory_capabilities1.61994234
42MP0002064_seizures1.56835811
43MP0005451_abnormal_body_composition1.55516605
44MP0002733_abnormal_thermal_nociception1.55417436
45MP0002184_abnormal_innervation1.55100125
46MP0002557_abnormal_social/conspecific_i1.52772200
47MP0001188_hyperpigmentation1.50323177
48MP0002272_abnormal_nervous_system1.49463356
49MP0003122_maternal_imprinting1.48898265
50MP0000383_abnormal_hair_follicle1.42876795
51MP0000751_myopathy1.42855904
52MP0001970_abnormal_pain_threshold1.42794176
53* MP0004742_abnormal_vestibular_system1.37041705
54MP0010386_abnormal_urinary_bladder1.34803594
55MP0001346_abnormal_lacrimal_gland1.33687179
56MP0004270_analgesia1.26670201
57* MP0000026_abnormal_inner_ear1.25745579
58MP0003941_abnormal_skin_development1.19607633
59MP0005165_increased_susceptibility_to1.19580251
60MP0000163_abnormal_cartilage_morphology1.16018847
61MP0002089_abnormal_postnatal_growth/wei1.12225001
62MP0008438_abnormal_cutaneous_collagen1.12018251
63MP0009384_cardiac_valve_regurgitation1.09546822
64MP0003183_abnormal_peptide_metabolism1.08333337
65MP0001905_abnormal_dopamine_level1.05296836
66MP0000427_abnormal_hair_cycle1.03576124
67MP0003698_abnormal_male_reproductive1.00415764
68MP0009764_decreased_sensitivity_to0.93686785
69MP0008877_abnormal_DNA_methylation0.93502730
70MP0002115_abnormal_skeleton_extremities0.92699812
71MP0009250_abnormal_appendicular_skeleto0.90071013
72MP0002108_abnormal_muscle_morphology0.89633710
73MP0000343_altered_response_to0.87865387
74MP0003868_abnormal_feces_composition0.87863558
75MP0004142_abnormal_muscle_tone0.87611614
76MP0008004_abnormal_stomach_pH0.87206603
77MP0008874_decreased_physiological_sensi0.85441151
78MP0010678_abnormal_skin_adnexa0.85214542
79MP0002896_abnormal_bone_mineralization0.78561895
80MP0005647_abnormal_sex_gland0.76637099
81* MP0002066_abnormal_motor_capabilities/c0.75634998
82MP0001299_abnormal_eye_distance/0.74648166
83MP0005508_abnormal_skeleton_morphology0.71511618
84MP0003566_abnormal_cell_adhesion0.71057159
85* MP0001502_abnormal_circadian_rhythm0.70884389
86MP0003121_genomic_imprinting0.70432960
87MP0002113_abnormal_skeleton_development0.70191983
88MP0010030_abnormal_orbit_morphology0.68964664
89MP0005166_decreased_susceptibility_to0.67557798
90MP0004858_abnormal_nervous_system0.67536395
91MP0005171_absent_coat_pigmentation0.67066037
92MP0000762_abnormal_tongue_morphology0.66939769
93MP0001485_abnormal_pinna_reflex0.65662820
94MP0001929_abnormal_gametogenesis0.65362549
95MP0001727_abnormal_embryo_implantation0.63941145
96MP0003633_abnormal_nervous_system0.60728485
97MP0003011_delayed_dark_adaptation0.60116692
98MP0004782_abnormal_surfactant_physiolog0.59236715
99MP0005390_skeleton_phenotype0.58351607
100MP0000579_abnormal_nail_morphology0.57938958

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.82121729
2Mesomelia (HP:0003027)6.28004853
3Irregular epiphyses (HP:0010582)5.92277147
4Focal motor seizures (HP:0011153)5.74090652
5Vitreoretinal degeneration (HP:0000655)4.80158709
6Small epiphyses (HP:0010585)4.79152034
7Abnormal ciliary motility (HP:0012262)4.63735386
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.19815514
9Abnormal tarsal ossification (HP:0008369)4.00583590
10Abnormal respiratory motile cilium physiology (HP:0012261)3.97927380
11Neonatal short-limb short stature (HP:0008921)3.88248463
12Hyperventilation (HP:0002883)3.83638925
13Hypoplastic ischia (HP:0003175)3.80923899
14Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.79413184
15Absent epiphyses (HP:0010577)3.79413184
16Short femoral neck (HP:0100864)3.70565094
17Abnormality of the vertebral endplates (HP:0005106)3.67786044
18Epileptic encephalopathy (HP:0200134)3.56338983
19Abnormality of the ischium (HP:0003174)3.45307059
20Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.40365090
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.30829623
22Absent/shortened dynein arms (HP:0200106)3.30829623
23Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.24482691
24Abnormality of femoral epiphyses (HP:0006499)3.24482691
25Febrile seizures (HP:0002373)3.23496907
26Abnormality of the epiphysis of the femoral head (HP:0010574)3.05964288
27Cupped ribs (HP:0000887)3.04475402
28Elevated erythrocyte sedimentation rate (HP:0003565)3.04388835
29Flattened epiphyses (HP:0003071)3.01455395
30Genu varum (HP:0002970)2.97899621
31Flat capital femoral epiphysis (HP:0003370)2.97083687
32Abnormality of the femoral head (HP:0003368)2.84934334
33Osteoarthritis (HP:0002758)2.83142429
34Akinesia (HP:0002304)2.79342451
35Mild short stature (HP:0003502)2.77969992
36Arthropathy (HP:0003040)2.70944345
37Metaphyseal irregularity (HP:0003025)2.70317057
38Irregular vertebral endplates (HP:0003301)2.69938145
39Split foot (HP:0001839)2.68749480
40Oligodactyly (hands) (HP:0001180)2.68293367
41Delayed epiphyseal ossification (HP:0002663)2.66963527
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66725878
43Infertility (HP:0000789)2.63983168
44Neonatal hypoglycemia (HP:0001998)2.56688128
45Ovoid vertebral bodies (HP:0003300)2.49148607
46Aplasia/hypoplasia of the femur (HP:0005613)2.47937183
47Focal seizures (HP:0007359)2.45117385
48Hypoplasia of the odontoid process (HP:0003311)2.45052778
49Lower limb amyotrophy (HP:0007210)2.44483508
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.41520749
51Generalized tonic-clonic seizures (HP:0002069)2.38164250
52Abnormality of the pubic bones (HP:0003172)2.37129241
53Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.36992723
54Broad-based gait (HP:0002136)2.34851547
55Long clavicles (HP:0000890)2.34846896
56Abnormal foot bone ossification (HP:0010675)2.34324170
57Short thorax (HP:0010306)2.34284182
58Atonic seizures (HP:0010819)2.32508829
59Severe Myopia (HP:0011003)2.29676514
60Flat acetabular roof (HP:0003180)2.29070669
61Broad palm (HP:0001169)2.23311756
62Absence seizures (HP:0002121)2.23271936
63Resting tremor (HP:0002322)2.22586696
64Postural instability (HP:0002172)2.20282757
65Coxa vara (HP:0002812)2.18916134
66Barrel-shaped chest (HP:0001552)2.18360399
67Distal lower limb muscle weakness (HP:0009053)2.13698561
68Abnormality of carpal bone ossification (HP:0006257)2.12690738
69Joint stiffness (HP:0001387)2.12097737
70Dialeptic seizures (HP:0011146)2.11314782
71Micromelia (HP:0002983)2.11310844
72Vascular calcification (HP:0004934)2.07616546
73Abnormal respiratory motile cilium morphology (HP:0005938)2.06124842
74Abnormal respiratory epithelium morphology (HP:0012253)2.06124842
75Spinal cord compression (HP:0002176)2.05569500
76Rhizomelia (HP:0008905)2.05142422
77Limited hip movement (HP:0008800)2.03482447
78Myositis (HP:0100614)2.02544074
79Thyroid-stimulating hormone excess (HP:0002925)2.02162654
80Abnormality of the odontoid process (HP:0003310)2.01631656
81Hyperphosphatemia (HP:0002905)2.01586160
82Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01088090
83Relative macrocephaly (HP:0004482)2.00759228
84Interstitial pulmonary disease (HP:0006530)2.00196589
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.99434875
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97243016
87Submucous cleft hard palate (HP:0000176)1.97127038
88Prostate neoplasm (HP:0100787)1.96931736
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95613151
90Abnormality of calcium-phosphate metabolism (HP:0100530)1.94677147
91Abnormal gallbladder physiology (HP:0012438)1.92347591
92Cholecystitis (HP:0001082)1.92347591
93Waddling gait (HP:0002515)1.92240082
94Distal lower limb amyotrophy (HP:0008944)1.92219987
95Cardiovascular calcification (HP:0011915)1.89135945
96Disproportionate short-trunk short stature (HP:0003521)1.87614612
97Azoospermia (HP:0000027)1.87457483
98Abnormal spermatogenesis (HP:0008669)1.86190852
99Fetal akinesia sequence (HP:0001989)1.85655230
100Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83094656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.88704366
2DAPK24.86369927
3CDK194.14175702
4OXSR12.55156224
5NTRK32.51189831
6AKT32.34520436
7MAP2K72.17933780
8EPHA42.15778952
9DAPK12.13703443
10SIK32.12275713
11STK38L1.99396751
12BCR1.77239070
13NME11.72000022
14MAP3K31.66586071
15MAP3K41.60621411
16EIF2AK21.39252298
17CAMKK21.36111252
18PLK21.32484375
19TNIK1.23864657
20STK241.23152162
21EIF2AK31.22862988
22DAPK31.20663872
23INSRR1.15929993
24DDR21.15199672
25PRKCG1.14646244
26CAMK2A1.13593838
27STK111.09200336
28TNK21.07782680
29TBK11.06728217
30PRKD31.03100213
31ICK0.99834161
32FGR0.95110860
33MUSK0.94351203
34PINK10.93643306
35FES0.87620832
36ADRBK20.86488515
37SIK10.85729827
38STK30.85719453
39MAP2K40.84003290
40MOS0.83594752
41SIK20.83064737
42MAP3K60.81190940
43CAMKK10.80214930
44SGK2230.74927558
45SGK4940.74927558
46SGK20.73687721
47CDK50.73644089
48PDK10.71835513
49LATS10.71038563
50PRKCE0.69971786
51PDK30.68736572
52PDK40.68736572
53MAPK70.66615935
54PRKG20.64823954
55PDPK10.64205288
56BRAF0.64088739
57BMPR20.63503804
58PRPF4B0.63063540
59FGFR10.62440677
60GRK50.58245657
61JAK10.57339082
62FER0.54263553
63MAP3K90.53359262
64PTK2B0.53261900
65MAP3K130.52094792
66STK390.50941866
67ADRBK10.50372404
68MAP3K140.49381655
69LATS20.48755453
70DYRK1A0.47378132
71SGK30.46822355
72MAPK40.44922466
73PDK20.43887089
74CDK180.43274628
75CAMK40.43087080
76AKT20.42966029
77SGK10.42763990
78CDK30.40126339
79CAMK2B0.39901156
80CDK150.37779308
81MKNK20.35776305
82NTRK20.35449108
83PRKACA0.35408506
84PRKCD0.34657167
85PRKCA0.33959231
86ERBB40.33817019
87MARK10.32994600
88TRPM70.32315778
89GRK10.32190502
90MAP3K120.30573710
91MAPK120.29860078
92CCNB10.28147657
93CDK140.27746231
94CDK11A0.26051396
95PRKG10.25675756
96CAMK10.23926393
97CDK80.23896219
98PRKACG0.23848393
99PRKCB0.23755344
100MAPK130.23738996

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.22495050
2Nicotine addiction_Homo sapiens_hsa050334.01614935
3Synaptic vesicle cycle_Homo sapiens_hsa047213.48504628
4Morphine addiction_Homo sapiens_hsa050322.48841871
5Vibrio cholerae infection_Homo sapiens_hsa051102.42384235
6Insulin secretion_Homo sapiens_hsa049112.24758491
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.22442621
8Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.08339938
9Salivary secretion_Homo sapiens_hsa049702.07024215
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.00313176
11Fatty acid biosynthesis_Homo sapiens_hsa000611.94615984
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93152814
13Olfactory transduction_Homo sapiens_hsa047401.83556002
14Glutamatergic synapse_Homo sapiens_hsa047241.76176720
15Propanoate metabolism_Homo sapiens_hsa006401.75816361
16Rheumatoid arthritis_Homo sapiens_hsa053231.74087317
17Circadian entrainment_Homo sapiens_hsa047131.73495324
18GABAergic synapse_Homo sapiens_hsa047271.71527652
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68006595
20Amphetamine addiction_Homo sapiens_hsa050311.52467079
21Ovarian steroidogenesis_Homo sapiens_hsa049131.44421684
22* Phagosome_Homo sapiens_hsa041451.41138327
23ECM-receptor interaction_Homo sapiens_hsa045121.40302780
24Arginine and proline metabolism_Homo sapiens_hsa003301.35179922
25Taste transduction_Homo sapiens_hsa047421.35029857
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33392726
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.19512887
28Calcium signaling pathway_Homo sapiens_hsa040201.15888904
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13485863
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13189392
31Protein digestion and absorption_Homo sapiens_hsa049741.10910493
32Renin secretion_Homo sapiens_hsa049241.08605362
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.08149041
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05096102
35Ether lipid metabolism_Homo sapiens_hsa005650.98767012
36Linoleic acid metabolism_Homo sapiens_hsa005910.93059842
37Long-term potentiation_Homo sapiens_hsa047200.92941937
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92891012
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90453676
40cAMP signaling pathway_Homo sapiens_hsa040240.90220197
41Serotonergic synapse_Homo sapiens_hsa047260.88036249
42Cocaine addiction_Homo sapiens_hsa050300.87245260
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84242811
44Type I diabetes mellitus_Homo sapiens_hsa049400.82933542
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.82485356
46Glycerolipid metabolism_Homo sapiens_hsa005610.79919243
47Histidine metabolism_Homo sapiens_hsa003400.79896515
48Axon guidance_Homo sapiens_hsa043600.78262732
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78203834
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75764602
51Allograft rejection_Homo sapiens_hsa053300.74794105
52Hedgehog signaling pathway_Homo sapiens_hsa043400.74155675
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73158985
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72992269
55beta-Alanine metabolism_Homo sapiens_hsa004100.72337098
56African trypanosomiasis_Homo sapiens_hsa051430.72136667
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70609290
58Cholinergic synapse_Homo sapiens_hsa047250.69131911
59Malaria_Homo sapiens_hsa051440.67477508
60Amoebiasis_Homo sapiens_hsa051460.67053684
61Dorso-ventral axis formation_Homo sapiens_hsa043200.66504526
62Steroid biosynthesis_Homo sapiens_hsa001000.64987150
63Long-term depression_Homo sapiens_hsa047300.64922798
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63883717
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62697706
66Circadian rhythm_Homo sapiens_hsa047100.61647387
67Phenylalanine metabolism_Homo sapiens_hsa003600.60112997
68Inositol phosphate metabolism_Homo sapiens_hsa005620.60008694
69Gastric acid secretion_Homo sapiens_hsa049710.59973614
70Glucagon signaling pathway_Homo sapiens_hsa049220.59829534
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59130753
72Non-homologous end-joining_Homo sapiens_hsa034500.56681349
73Bile secretion_Homo sapiens_hsa049760.54184200
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53058151
75Dilated cardiomyopathy_Homo sapiens_hsa054140.51603142
76Tryptophan metabolism_Homo sapiens_hsa003800.50380214
77Dopaminergic synapse_Homo sapiens_hsa047280.50023642
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48779364
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48454976
80Oxytocin signaling pathway_Homo sapiens_hsa049210.47092842
81Vitamin digestion and absorption_Homo sapiens_hsa049770.45322301
82Ras signaling pathway_Homo sapiens_hsa040140.44545023
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.42669607
84Gap junction_Homo sapiens_hsa045400.42460132
85Retinol metabolism_Homo sapiens_hsa008300.41982139
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41743504
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41211776
88Arginine biosynthesis_Homo sapiens_hsa002200.40677775
89Pyruvate metabolism_Homo sapiens_hsa006200.37690923
90Type II diabetes mellitus_Homo sapiens_hsa049300.36398454
91Fatty acid degradation_Homo sapiens_hsa000710.33662180
92Phototransduction_Homo sapiens_hsa047440.32842399
93Fatty acid metabolism_Homo sapiens_hsa012120.31812668
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30868518
95Pancreatic secretion_Homo sapiens_hsa049720.30574431
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30258020
97TNF signaling pathway_Homo sapiens_hsa046680.29717338
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29559157
99Sphingolipid metabolism_Homo sapiens_hsa006000.28388987
100Complement and coagulation cascades_Homo sapiens_hsa046100.27256928

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