NOXA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)7.63590904
2flavonoid metabolic process (GO:0009812)7.16237303
3viral transcription (GO:0019083)6.92564724
4ribosomal small subunit assembly (GO:0000028)6.88366211
5translational termination (GO:0006415)6.61851812
6ketone body metabolic process (GO:1902224)6.59634926
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.48907806
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.90501258
9ATP synthesis coupled proton transport (GO:0015986)5.90501258
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.56100315
11translational elongation (GO:0006414)5.54347775
12ribosomal small subunit biogenesis (GO:0042274)5.51030974
13cotranslational protein targeting to membrane (GO:0006613)5.46259642
14protein targeting to ER (GO:0045047)5.45696301
15* regulation of respiratory burst (GO:0060263)5.21248303
16cellular protein complex disassembly (GO:0043624)5.19157485
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19069054
18protein localization to endoplasmic reticulum (GO:0070972)5.16851084
19viral life cycle (GO:0019058)5.16542720
20negative regulation of epidermal cell differentiation (GO:0045605)5.08540175
21ribosomal large subunit biogenesis (GO:0042273)5.07290685
22sulfation (GO:0051923)4.98693143
23cellular glucuronidation (GO:0052695)4.80471097
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.73722593
25mannose metabolic process (GO:0006013)4.73559472
26respiratory electron transport chain (GO:0022904)4.70001311
27electron transport chain (GO:0022900)4.57269105
28negative regulation of erythrocyte differentiation (GO:0045647)4.56049250
29keratinocyte development (GO:0003334)4.53004175
30UDP-N-acetylglucosamine metabolic process (GO:0006047)4.47215693
31protein complex disassembly (GO:0043241)4.47012010
32maturation of SSU-rRNA (GO:0030490)4.42482997
33uronic acid metabolic process (GO:0006063)4.31751698
34glucuronate metabolic process (GO:0019585)4.31751698
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.21635473
36positive regulation of chemokine secretion (GO:0090197)4.20252130
37regulation of metalloenzyme activity (GO:0048552)4.18821385
38sulfur amino acid catabolic process (GO:0000098)4.17940676
39translational initiation (GO:0006413)4.17714158
40regulation of chemokine secretion (GO:0090196)4.14280020
41macromolecular complex disassembly (GO:0032984)4.12957159
42primary alcohol catabolic process (GO:0034310)4.11865673
43antibacterial humoral response (GO:0019731)4.11478914
44antimicrobial humoral response (GO:0019730)4.10463212
45response to nitrosative stress (GO:0051409)4.05886271
46bundle of His cell to Purkinje myocyte communication (GO:0086069)4.04391458
47positive regulation of respiratory burst (GO:0060267)4.03902034
48calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.03582232
49intestinal absorption (GO:0050892)3.99723205
50bile acid and bile salt transport (GO:0015721)3.97729509
51intestinal epithelial cell development (GO:0060576)3.97377605
52ethanol metabolic process (GO:0006067)3.81680484
53regulation of bile acid biosynthetic process (GO:0070857)3.75693343
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74829919
55negative regulation of epidermis development (GO:0045683)3.73096469
56maintenance of gastrointestinal epithelium (GO:0030277)3.70400042
57phenylpropanoid metabolic process (GO:0009698)3.63595795
58ATP biosynthetic process (GO:0006754)3.63056967
59proline biosynthetic process (GO:0006561)3.62651914
60protein targeting to membrane (GO:0006612)3.56797254
61regulation of ARF GTPase activity (GO:0032312)3.53666438
62respiratory chain complex IV assembly (GO:0008535)3.52543934
63GDP-mannose metabolic process (GO:0019673)3.44268432
64lipopolysaccharide biosynthetic process (GO:0009103)3.42139870
653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.41622444
66purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.41622444
67hepatocyte apoptotic process (GO:0097284)3.37998808
68oxidative phosphorylation (GO:0006119)3.36286036
69cell-cell junction maintenance (GO:0045217)3.35017069
70inner mitochondrial membrane organization (GO:0007007)3.34829640
71cytidine deamination (GO:0009972)3.26331943
72cytidine metabolic process (GO:0046087)3.26331943
73cytidine catabolic process (GO:0006216)3.26331943
74glucocorticoid biosynthetic process (GO:0006704)3.25496182
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23762637
76purine nucleoside triphosphate biosynthetic process (GO:0009145)3.22729811
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.19408084
78nucleotide-sugar biosynthetic process (GO:0009226)3.18172257
79positive regulation of triglyceride lipase activity (GO:0061365)3.16617843
80positive regulation of lipoprotein lipase activity (GO:0051006)3.16617843
81regulation of vitamin metabolic process (GO:0030656)3.13807182
82translation (GO:0006412)3.12375173
83regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.11177933
84galactose catabolic process (GO:0019388)3.04400296
85homocysteine metabolic process (GO:0050667)3.04300861
86pyrimidine nucleoside salvage (GO:0043097)3.01805275
87pyrimidine-containing compound salvage (GO:0008655)3.01805275
88negative regulation of cell size (GO:0045792)3.01256277
89regulation of cellular extravasation (GO:0002691)2.99279348
90semaphorin-plexin signaling pathway (GO:0071526)2.98286939
91regulation of viral entry into host cell (GO:0046596)2.97979595
92nucleoside salvage (GO:0043174)2.96164413
93cell differentiation involved in embryonic placenta development (GO:0060706)2.95964020
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.93599810
95negative regulation of transcription by competitive promoter binding (GO:0010944)2.91437062
96negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.90688413
97pyrimidine-containing compound transmembrane transport (GO:0072531)2.90430783
98complement activation, alternative pathway (GO:0006957)2.89793753
99negative regulation of keratinocyte proliferation (GO:0010839)2.89004118
100negative regulation of viral entry into host cell (GO:0046597)2.87145684
101negative regulation of glial cell proliferation (GO:0060253)2.87136687
102ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87119210
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.86948132
104synaptic vesicle exocytosis (GO:0016079)2.84692122
105epithelial structure maintenance (GO:0010669)2.84689006
106intestinal cholesterol absorption (GO:0030299)2.83683350
107citrulline biosynthetic process (GO:0019240)2.82669872
108mRNA catabolic process (GO:0006402)2.81852919
109nucleotide-sugar metabolic process (GO:0009225)2.81297625
110phosphatidylserine acyl-chain remodeling (GO:0036150)2.80909891
111positive regulation of pseudopodium assembly (GO:0031274)2.78460567
112lipopolysaccharide metabolic process (GO:0008653)2.77887080
113hydrogen ion transmembrane transport (GO:1902600)2.77408331
114positive regulation of protein kinase C signaling (GO:0090037)2.73003912
115positive regulation of fatty acid biosynthetic process (GO:0045723)2.68489100
116phospholipid efflux (GO:0033700)2.66627973
117activation of Rac GTPase activity (GO:0032863)2.65128950
118response to manganese ion (GO:0010042)2.60650607
119regulation of ARF protein signal transduction (GO:0032012)2.58666275
120positive regulation of histone deacetylation (GO:0031065)2.58206599
121cell junction maintenance (GO:0034331)2.57738573
122activation of MAPKKK activity (GO:0000185)2.57500219
123activation of JUN kinase activity (GO:0007257)2.56934196
124regulation of cholesterol esterification (GO:0010872)2.55244033
125regulation of cholesterol metabolic process (GO:0090181)2.53965519
126phosphatidylglycerol biosynthetic process (GO:0006655)2.52103349
127regulation of monocyte differentiation (GO:0045655)2.52012947
128amyloid precursor protein metabolic process (GO:0042982)2.51202213
129protein kinase C signaling (GO:0070528)2.50714384
130amyloid precursor protein catabolic process (GO:0042987)2.50486959
131negative regulation of granulocyte differentiation (GO:0030853)2.50301521
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49178270
133detection of bacterium (GO:0016045)2.47303770
134positive regulation of triglyceride metabolic process (GO:0090208)2.44157214
135regulation of T-helper 2 cell differentiation (GO:0045628)2.44051622
136response to peptidoglycan (GO:0032494)2.43905592
137regulation of myeloid leukocyte mediated immunity (GO:0002886)2.43184557
138negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37950578
139response to muramyl dipeptide (GO:0032495)2.37357020
140macrophage activation involved in immune response (GO:0002281)2.36554791
141regulation of leukocyte degranulation (GO:0043300)2.36546215
142regulation of cholesterol biosynthetic process (GO:0045540)2.36262922
143antigen processing and presentation of endogenous antigen (GO:0019883)2.35897715
144glycosphingolipid catabolic process (GO:0046479)2.33885669
145regulation of cholesterol homeostasis (GO:2000188)2.33820091
146triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33051562
147positive regulation of receptor recycling (GO:0001921)2.31424742
148glutathione biosynthetic process (GO:0006750)2.30617624
149detection of other organism (GO:0098543)2.29117706
150cellular response to thyroid hormone stimulus (GO:0097067)2.28048639
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.27913917
152cytoskeletal anchoring at plasma membrane (GO:0007016)2.27298491
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.27223100
154regulation of ruffle assembly (GO:1900027)2.26488715
155apoptotic process involved in morphogenesis (GO:0060561)2.25780738
156signal complex assembly (GO:0007172)2.25350761
157positive regulation of synapse maturation (GO:0090129)2.24844669
158regulation of mast cell degranulation (GO:0043304)2.24772340
159positive regulation of lipid catabolic process (GO:0050996)2.23953865
160histone H4 deacetylation (GO:0070933)2.22098586
161NIK/NF-kappaB signaling (GO:0038061)2.22043551
162endothelial cell chemotaxis (GO:0035767)2.21661206
163G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.21572371
164Arp2/3 complex-mediated actin nucleation (GO:0034314)2.20159242
165negative regulation of interleukin-2 production (GO:0032703)2.18393112
166response to thyroid hormone (GO:0097066)2.18267831
167regulation of fatty acid biosynthetic process (GO:0042304)2.16308991
168antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.16123261
169immunoglobulin mediated immune response (GO:0016064)2.15528870
170germinal center formation (GO:0002467)2.14705423
171thymic T cell selection (GO:0045061)2.14615219
172epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14323264
173N-acetylneuraminate metabolic process (GO:0006054)2.13983805
174protein retention in ER lumen (GO:0006621)2.13320644
175cellular response to virus (GO:0098586)2.12734587
176histone H3 deacetylation (GO:0070932)2.12089117
177regulation of apoptotic cell clearance (GO:2000425)2.11659330
178barbed-end actin filament capping (GO:0051016)2.11275762
179regulation of regulated secretory pathway (GO:1903305)2.10967181
180cell volume homeostasis (GO:0006884)2.10896028
181regulation of extracellular matrix disassembly (GO:0010715)2.09351099
182urea metabolic process (GO:0019627)2.08268843
183glycolipid catabolic process (GO:0019377)2.08222876
184positive thymic T cell selection (GO:0045059)2.08082351
185phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.07518213
186UV protection (GO:0009650)2.07340241
187positive regulation of Rap GTPase activity (GO:0032854)2.06709759
188adenosine receptor signaling pathway (GO:0001973)2.05797700
189lytic vacuole organization (GO:0080171)2.05543856
190lysosome organization (GO:0007040)2.05543856
191Rho protein signal transduction (GO:0007266)2.05535460
192positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.05056036
193urea cycle (GO:0000050)2.04610399
194actin filament polymerization (GO:0030041)2.04536386
195nitrogen cycle metabolic process (GO:0071941)2.03176733
196glutamate secretion (GO:0014047)2.02867837
197epithelial cell-cell adhesion (GO:0090136)2.02363503
198nonribosomal peptide biosynthetic process (GO:0019184)2.01932657
199positive regulation of cholesterol efflux (GO:0010875)2.01575283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.60909691
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.61861340
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.47356573
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.35410653
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.85006691
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.70469908
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47450502
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40672722
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.39705344
10SOX2_27498859_Chip-Seq_STOMACH_Mouse3.39418046
11LXR_22292898_ChIP-Seq_THP-1_Human3.20551721
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.96963163
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.92524574
14GATA6_25053715_ChIP-Seq_YYC3_Human2.74984951
15VDR_21846776_ChIP-Seq_THP-1_Human2.69864989
16GATA4_25053715_ChIP-Seq_YYC3_Human2.66404384
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64590636
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61010639
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.58339762
20SOX2_20726797_ChIP-Seq_SW620_Human2.56350524
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48036849
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38336806
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38232724
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38141789
25E2F7_22180533_ChIP-Seq_HELA_Human2.33533178
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31154553
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23796382
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19666515
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19611120
30* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17845804
31ELK3_25401928_ChIP-Seq_HUVEC_Human2.15240489
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.13843854
33LXR_22158963_ChIP-Seq_LIVER_Mouse2.12923766
34KDM2B_26808549_Chip-Seq_DND41_Human2.11253877
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09675428
36P68_20966046_ChIP-Seq_HELA_Human2.02874422
37* TCF7_22412390_ChIP-Seq_EML_Mouse2.01370273
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.97117201
39KDM2B_26808549_Chip-Seq_K562_Human1.96450278
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95610357
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94885710
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.90384482
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88872324
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87220687
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85953889
46MYC_22102868_ChIP-Seq_BL_Human1.77364554
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76049692
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.75759098
49SMC4_20622854_ChIP-Seq_HELA_Human1.75351197
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73070528
51DROSHA_22980978_ChIP-Seq_HELA_Human1.70484743
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70447271
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.68127102
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.66217423
55AR_21909140_ChIP-Seq_LNCAP_Human1.64957301
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62486881
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61756597
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61253625
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60503013
60CTCF_27219007_Chip-Seq_Bcells_Human1.59871317
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59417020
62CREB1_26743006_Chip-Seq_LNCaP_Human1.59028895
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58762427
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.57770122
65VDR_24763502_ChIP-Seq_THP-1_Human1.57494208
66XRN2_22483619_ChIP-Seq_HELA_Human1.57312332
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.53938638
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53215696
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51760722
70ZNF263_19887448_ChIP-Seq_K562_Human1.50826444
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.48389202
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48213073
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46612233
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46082231
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45775792
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44163293
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.43077973
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43024988
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42724627
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42321709
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39243587
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38055530
83* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37682002
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34023064
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33251151
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30772568
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.29708875
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.28986446
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28632900
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.27540983
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27362009
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26904043
93MAF_26560356_Chip-Seq_TH2_Human1.26113928
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.25862482
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25244637
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25030347
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24920224
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24845697
99SCL_19346495_ChIP-Seq_HPC-7_Human1.24182035
100E2F1_20622854_ChIP-Seq_HELA_Human1.22952661
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22193415
102MAF_26560356_Chip-Seq_TH1_Human1.22120704
103SA1_27219007_Chip-Seq_Bcells_Human1.20709193
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.19821162
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19648108
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19027417
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18960549
108* TP63_22573176_ChIP-Seq_HFKS_Human1.17359138
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15869031
110NANOG_20526341_ChIP-Seq_ESCs_Human1.15630586
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15197589
112* CTCF_26484167_Chip-Seq_Bcells_Mouse1.14172740
113STAT1_20625510_ChIP-Seq_HELA_Human1.11708596
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11536117
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11115180
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11062779
117CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08144803
118UTX_26944678_Chip-Seq_JUKART_Human1.08112699
119CTCF_20526341_ChIP-Seq_ESCs_Human1.07640681
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07514314
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07246946
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06585560
123IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06296981
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06111775
125FOXM1_23109430_ChIP-Seq_U2OS_Human1.05919536
126* RARB_24833708_ChIP-Seq_LIVER_Mouse1.03852978
127NCOR1_26117541_ChIP-Seq_K562_Human1.03562145
128* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03316185
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03100702
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02986019
131E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01896461
132MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01696317
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01571254
134FOXO3_23340844_ChIP-Seq_DLD1_Human1.01385644
135ELF5_23300383_ChIP-Seq_T47D_Human1.01256303
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00967655
137* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00503574
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00169581
139GATA1_19941826_ChIP-Seq_K562_Human0.98314018
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98254798
141SPI1_23127762_ChIP-Seq_K562_Human0.98224283
142TTF2_22483619_ChIP-Seq_HELA_Human0.98144415
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97957990
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97706228
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97513719
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97020906
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.96190037
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96079888
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96065525
150FOXP3_21729870_ChIP-Seq_TREG_Human0.94958878
151GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94799605
152RACK7_27058665_Chip-Seq_MCF-7_Human0.94256258
153PHF8_20622854_ChIP-Seq_HELA_Human0.93184369
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93106667
155GATA1_22025678_ChIP-Seq_K562_Human0.91998544
156KLF5_25053715_ChIP-Seq_YYC3_Human0.91654320
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.91179364
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.90993147
159FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89947592
160* ATF3_27146783_Chip-Seq_COLON_Human0.89710913
161BCL6_27268052_Chip-Seq_Bcells_Human0.89236052
162* DCP1A_22483619_ChIP-Seq_HELA_Human0.88393659
163* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88351416
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87542389
165HNF4A_19822575_ChIP-Seq_HepG2_Human0.86566494
166E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85283126
167SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85059174
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83848659
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83539740
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83539740
171JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82499028
172CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82266570
173MYC_18940864_ChIP-ChIP_HL60_Human0.81129560
174GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79896087
175BCOR_27268052_Chip-Seq_Bcells_Human0.79158157
176GATA3_21867929_ChIP-Seq_CD8_Mouse0.76852755
177RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76542041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.35562655
2MP0009379_abnormal_foot_pigmentation4.23106260
3MP0010234_abnormal_vibrissa_follicle4.11187669
4MP0000462_abnormal_digestive_system3.83770192
5MP0008004_abnormal_stomach_pH3.72911017
6MP0005085_abnormal_gallbladder_physiolo3.60310257
7MP0005360_urolithiasis3.58632562
8MP0003172_abnormal_lysosome_physiology3.52399035
9MP0001873_stomach_inflammation3.30692087
10MP0002139_abnormal_hepatobiliary_system3.30107416
11MP0001666_abnormal_nutrient_absorption3.29001702
12MP0003866_abnormal_defecation3.20509905
13MP0000490_abnormal_crypts_of3.10315335
14MP0010155_abnormal_intestine_physiology3.10009756
15MP0001663_abnormal_digestive_system2.94665842
16MP0004264_abnormal_extraembryonic_tissu2.90980188
17MP0003693_abnormal_embryo_hatching2.90196448
18MP0005381_digestive/alimentary_phenotyp2.78435143
19MP0003436_decreased_susceptibility_to2.73749983
20MP0005365_abnormal_bile_salt2.53799499
21MP0003303_peritoneal_inflammation2.44862229
22MP0010352_gastrointestinal_tract_polyps2.33022066
23MP0001664_abnormal_digestion2.27701466
24MP0009278_abnormal_bone_marrow2.26032013
25MP0008260_abnormal_autophagy2.25252447
26MP0005409_darkened_coat_color2.23266817
27MP0003183_abnormal_peptide_metabolism2.22100849
28MP0002277_abnormal_respiratory_mucosa2.17299398
29MP0003868_abnormal_feces_composition2.16095849
30MP0000477_abnormal_intestine_morphology2.15082411
31MP0008875_abnormal_xenobiotic_pharmacok2.12868125
32MP0003283_abnormal_digestive_organ2.12662339
33MP0003787_abnormal_imprinting2.10205362
34MP0005451_abnormal_body_composition2.08165041
35MP0003123_paternal_imprinting2.03344606
36MP0003300_gastrointestinal_ulcer2.02242508
37MP0004510_myositis1.93613479
38MP0003075_altered_response_to1.85091782
39MP0002249_abnormal_larynx_morphology1.80823121
40MP0003806_abnormal_nucleotide_metabolis1.80348182
41MP0002132_abnormal_respiratory_system1.74617214
42MP0003252_abnormal_bile_duct1.72174255
43MP0005174_abnormal_tail_pigmentation1.71941044
44MP0004859_abnormal_synaptic_plasticity1.71164255
45MP0006054_spinal_hemorrhage1.64949159
46MP0000013_abnormal_adipose_tissue1.63178489
47MP0000678_abnormal_parathyroid_gland1.58225708
48MP0004957_abnormal_blastocyst_morpholog1.56062003
49MP0000470_abnormal_stomach_morphology1.51019938
50MP0003690_abnormal_glial_cell1.47391215
51MP0004858_abnormal_nervous_system1.47131508
52MP0003329_amyloid_beta_deposits1.43229172
53MP0005670_abnormal_white_adipose1.42341547
54MP0005666_abnormal_adipose_tissue1.41897718
55MP0002419_abnormal_innate_immunity1.41748068
56MP0002796_impaired_skin_barrier1.39558561
57MP0003567_abnormal_fetal_cardiomyocyte1.39162224
58MP0005083_abnormal_biliary_tract1.35537960
59MP0000604_amyloidosis1.35122750
60MP0002166_altered_tumor_susceptibility1.35063363
61MP0005375_adipose_tissue_phenotype1.34331253
62MP0003011_delayed_dark_adaptation1.34104945
63MP0000003_abnormal_adipose_tissue1.31339710
64MP0005076_abnormal_cell_differentiation1.31162840
65MP0005636_abnormal_mineral_homeostasis1.30565218
66MP0009840_abnormal_foam_cell1.30497416
67MP0004019_abnormal_vitamin_homeostasis1.29864303
68MP0009785_altered_susceptibility_to1.29394594
69MP0005464_abnormal_platelet_physiology1.27783993
70MP0004947_skin_inflammation1.27580252
71MP0009643_abnormal_urine_homeostasis1.27183547
72MP0010329_abnormal_lipoprotein_level1.26042002
73MP0005387_immune_system_phenotype1.25360499
74MP0001790_abnormal_immune_system1.25360499
75MP0001533_abnormal_skeleton_physiology1.25159820
76MP0003705_abnormal_hypodermis_morpholog1.24921721
77MP0005000_abnormal_immune_tolerance1.22513650
78MP0008874_decreased_physiological_sensi1.21972320
79MP0003453_abnormal_keratinocyte_physiol1.19229380
80MP0006082_CNS_inflammation1.18557949
81MP0002396_abnormal_hematopoietic_system1.18395397
82MP0002060_abnormal_skin_morphology1.18180569
83MP0001765_abnormal_ion_homeostasis1.16502359
84MP0001849_ear_inflammation1.15253261
85MP0000537_abnormal_urethra_morphology1.14577218
86MP0002933_joint_inflammation1.13938127
87MP0002138_abnormal_hepatobiliary_system1.13396461
88MP0005084_abnormal_gallbladder_morpholo1.11679692
89MP0000465_gastrointestinal_hemorrhage1.08924302
90MP0008872_abnormal_physiological_respon1.08814974
91MP0004782_abnormal_surfactant_physiolog1.08420408
92MP0004381_abnormal_hair_follicle1.08062083
93MP0002998_abnormal_bone_remodeling1.05684656
94MP0003315_abnormal_perineum_morphology1.05535634
95MP0003941_abnormal_skin_development1.04496433
96MP0001835_abnormal_antigen_presentation1.04281849
97MP0003724_increased_susceptibility_to1.03884518
98MP0002006_tumorigenesis1.02334184
99MP0000751_myopathy1.01920719
100MP0005535_abnormal_body_temperature1.01610118
101MP0002723_abnormal_immune_serum1.00306237
102MP0000681_abnormal_thyroid_gland0.99757186
103MP0002118_abnormal_lipid_homeostasis0.96435550
104MP0010678_abnormal_skin_adnexa0.96366573
105MP0000858_altered_metastatic_potential0.96186351
106MP0002452_abnormal_antigen_presenting0.95523495
107MP0004185_abnormal_adipocyte_glucose0.95057665
108MP0001800_abnormal_humoral_immune0.93039603
109MP0000685_abnormal_immune_system0.92366399
110MP0005332_abnormal_amino_acid0.91247421
111MP0001764_abnormal_homeostasis0.91037946
112MP0002089_abnormal_postnatal_growth/wei0.88258903
113MP0005167_abnormal_blood-brain_barrier0.88211401
114MP0001502_abnormal_circadian_rhythm0.87897831
115MP0001819_abnormal_immune_cell0.87840069
116MP0005501_abnormal_skin_physiology0.87229761
117MP0009333_abnormal_splenocyte_physiolog0.85668953
118MP0002420_abnormal_adaptive_immunity0.85400446
119MP0003191_abnormal_cellular_cholesterol0.85206353
120MP0001216_abnormal_epidermal_layer0.83811987
121MP0001485_abnormal_pinna_reflex0.83605608
122MP0005310_abnormal_salivary_gland0.83307662
123MP0000920_abnormal_myelination0.83218941
124MP0006036_abnormal_mitochondrial_physio0.82823339
125MP0005319_abnormal_enzyme/_coenzyme0.82608183
126MP0003879_abnormal_hair_cell0.80684796
127MP0002822_catalepsy0.79657347
128MP0005671_abnormal_response_to0.78134004
129MP0003634_abnormal_glial_cell0.78113040
130MP0003186_abnormal_redox_activity0.77390239
131MP0001845_abnormal_inflammatory_respons0.77069796
132MP0003279_aneurysm0.77002295
133MP0005025_abnormal_response_to0.74360916
134MP0002064_seizures0.73617710
135MP0000613_abnormal_salivary_gland0.73150888
136MP0000747_muscle_weakness0.73038280
137MP0000249_abnormal_blood_vessel0.72798149
138MP0001756_abnormal_urination0.71434566
139MP0005166_decreased_susceptibility_to0.71030663
140MP0005220_abnormal_exocrine_pancreas0.70975719
141MP0010771_integument_phenotype0.70584884
142MP0002098_abnormal_vibrissa_morphology0.68669738
143MP0005397_hematopoietic_system_phenotyp0.67555929
144MP0001545_abnormal_hematopoietic_system0.67555929
145MP0009697_abnormal_copulation0.66728674
146MP0000538_abnormal_urinary_bladder0.66445833
147MP0003638_abnormal_response/metabolism_0.65748344
148MP0002009_preneoplasia0.65673832
149MP0000467_abnormal_esophagus_morphology0.65404270
150MP0003878_abnormal_ear_physiology0.64477840
151MP0005377_hearing/vestibular/ear_phenot0.64477840
152MP0005584_abnormal_enzyme/coenzyme_acti0.62982294
153MP0000609_abnormal_liver_physiology0.60893747
154MP0003119_abnormal_digestive_system0.59469183
155MP0002136_abnormal_kidney_physiology0.57795124
156MP0010386_abnormal_urinary_bladder0.56933500
157MP0002148_abnormal_hypersensitivity_rea0.56416493
158MP0008469_abnormal_protein_level0.55930255
159MP0002254_reproductive_system_inflammat0.55904567
160MP0000383_abnormal_hair_follicle0.55659773

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)5.70897280
2Ventricular fibrillation (HP:0001663)5.49944489
3Increased intramyocellular lipid droplets (HP:0012240)5.42113000
4Abnormal hemoglobin (HP:0011902)5.15379676
5Increased muscle lipid content (HP:0009058)5.07653975
6Macrocytic anemia (HP:0001972)4.40824723
7J-shaped sella turcica (HP:0002680)4.40075359
8Increased hepatocellular lipid droplets (HP:0006565)4.38253599
9Lipid accumulation in hepatocytes (HP:0006561)4.32565350
10Reticulocytopenia (HP:0001896)4.19540240
11Abnormality of cells of the erythroid lineage (HP:0012130)4.12534380
12Metabolic alkalosis (HP:0200114)4.03451294
13Renal Fanconi syndrome (HP:0001994)3.99733715
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.95852065
15Dysostosis multiplex (HP:0000943)3.95124647
16Obstructive sleep apnea (HP:0002870)3.91624286
17Abnormal number of erythroid precursors (HP:0012131)3.82377922
18Hepatic necrosis (HP:0002605)3.81380080
19Congenital sensorineural hearing impairment (HP:0008527)3.77301647
20Systemic lupus erythematosus (HP:0002725)3.75292908
21Hepatocellular necrosis (HP:0001404)3.73588879
22Decreased circulating renin level (HP:0003351)3.70823713
23Pustule (HP:0200039)3.65005455
24Mitochondrial inheritance (HP:0001427)3.60881111
25Pallor (HP:0000980)3.56447134
26Exertional dyspnea (HP:0002875)3.52598388
27Increased cerebral lipofuscin (HP:0011813)3.49717238
28Urinary glycosaminoglycan excretion (HP:0003541)3.42894102
29Mucopolysacchariduria (HP:0008155)3.42894102
30Abnormality of polysaccharide metabolism (HP:0011012)3.41881132
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.41881132
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.41881132
33Abnormality of urine glucose concentration (HP:0011016)3.34030296
34Glycosuria (HP:0003076)3.34030296
35Right ventricular cardiomyopathy (HP:0011663)3.25987827
36Loss of speech (HP:0002371)3.22764793
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.19742471
38Axonal loss (HP:0003447)3.13408206
39Abnormality of liposaccharide metabolism (HP:0010968)3.10893984
40Abnormality of glycosphingolipid metabolism (HP:0004343)3.10893984
41Abnormality of glycolipid metabolism (HP:0010969)3.10893984
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.10799134
43Pili torti (HP:0003777)3.06308692
44Neurofibrillary tangles (HP:0002185)3.05917820
45Stridor (HP:0010307)3.05693014
46Nuclear cataract (HP:0100018)3.05363971
47Glomerulonephritis (HP:0000099)3.01376518
48Increased CSF lactate (HP:0002490)2.99206770
49Intrahepatic cholestasis (HP:0001406)2.95536121
50Hemorrhage of the eye (HP:0011885)2.92050799
51Myokymia (HP:0002411)2.90322791
52Colitis (HP:0002583)2.89017451
53Increased serum lactate (HP:0002151)2.88712659
54Cerebral aneurysm (HP:0004944)2.87951616
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83526855
56Sensory axonal neuropathy (HP:0003390)2.76649863
57Neuronal loss in central nervous system (HP:0002529)2.75806402
58Abnormality of renal resorption (HP:0011038)2.74325161
59Abnormal hair laboratory examination (HP:0003328)2.72318371
60Complement deficiency (HP:0004431)2.71113310
61Supranuclear gaze palsy (HP:0000605)2.70465811
62Deep venous thrombosis (HP:0002625)2.68927916
63Cervical subluxation (HP:0003308)2.66154802
64Broad face (HP:0000283)2.65458034
65Rectal prolapse (HP:0002035)2.59632837
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58569760
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58569760
68Abnormal mitochondria in muscle tissue (HP:0008316)2.55638897
69Hyperammonemia (HP:0001987)2.54264228
70Abnormality of small intestinal villus morphology (HP:0011472)2.54228204
71Villous atrophy (HP:0011473)2.54228204
72Thrombocytosis (HP:0001894)2.50561474
73Thin bony cortex (HP:0002753)2.50461643
74Distal lower limb muscle weakness (HP:0009053)2.49861905
75Malnutrition (HP:0004395)2.49057149
76Abnormality of complement system (HP:0005339)2.48634887
77Acute encephalopathy (HP:0006846)2.47908527
78Joint stiffness (HP:0001387)2.47250470
79Woolly hair (HP:0002224)2.46160734
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45144768
81Cheilitis (HP:0100825)2.44866676
82Abnormality of the vitamin B12 metabolism (HP:0004341)2.44444340
83Abnormality of fatty-acid metabolism (HP:0004359)2.44117913
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43506756
853-Methylglutaconic aciduria (HP:0003535)2.43016792
86Eczematoid dermatitis (HP:0000976)2.42703272
87Ankle clonus (HP:0011448)2.42621141
88Abdominal distention (HP:0003270)2.42207979
89Hyperphosphaturia (HP:0003109)2.42166774
90Distal upper limb amyotrophy (HP:0007149)2.41553516
91Upper limb amyotrophy (HP:0009129)2.41553516
92Micronodular cirrhosis (HP:0001413)2.39356817
93Respiratory difficulties (HP:0002880)2.38830124
94Alkalosis (HP:0001948)2.38506132
95Ridged nail (HP:0001807)2.35989664
96Deformed sella turcica (HP:0002681)2.35196919
97Abnormality of renin-angiotensin system (HP:0000847)2.34019771
98Flat acetabular roof (HP:0003180)2.33090967
99Conjugated hyperbilirubinemia (HP:0002908)2.32364709
100Cerebral inclusion bodies (HP:0100314)2.30755974
101Abnormality of vitamin B metabolism (HP:0004340)2.30424812
102Lymphangioma (HP:0100764)2.30424764
103Biliary tract neoplasm (HP:0100574)2.27930003
104Visual hallucinations (HP:0002367)2.27842567
105Acute necrotizing encephalopathy (HP:0006965)2.27156984
106Amyloidosis (HP:0011034)2.27019731
107Myositis (HP:0100614)2.26602123
108Gastrointestinal inflammation (HP:0004386)2.24418221
109Gastrointestinal dysmotility (HP:0002579)2.24291213
110Distal lower limb amyotrophy (HP:0008944)2.23250919
111Purpura (HP:0000979)2.22985765
112Gingivitis (HP:0000230)2.19271069
113Bulbar palsy (HP:0001283)2.19069460
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18906138
115Male infertility (HP:0003251)2.17788246
116Generalized aminoaciduria (HP:0002909)2.17287676
117Hypoglycemic coma (HP:0001325)2.16800070
118Recurrent abscess formation (HP:0002722)2.16722023
119Easy fatigability (HP:0003388)2.15534994
120Thoracic kyphosis (HP:0002942)2.15513213
121Abnormality of chloride homeostasis (HP:0011422)2.14597973
122Lactic acidosis (HP:0003128)2.13697644
123Colon cancer (HP:0003003)2.13499082
124Abnormality of the nasal mucosa (HP:0000433)2.11975059
125Asymmetric septal hypertrophy (HP:0001670)2.11846881
126Posterior subcapsular cataract (HP:0007787)2.09543568
127Dicarboxylic aciduria (HP:0003215)2.09105208
128Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09105208
12911 pairs of ribs (HP:0000878)2.07447197
130Inflammation of the large intestine (HP:0002037)2.07426507
131Fat malabsorption (HP:0002630)2.05314999
132Growth hormone excess (HP:0000845)2.04843692
133Trismus (HP:0000211)2.04520725
134Abnormality of the thoracic spine (HP:0100711)2.03814696
135Syncope (HP:0001279)2.03213451
136Recurrent bacterial skin infections (HP:0005406)2.03119577
137Hypophosphatemia (HP:0002148)2.03078287
138Abnormality of macrophages (HP:0004311)2.02812189
139Nephritis (HP:0000123)2.02621794
140Sensorimotor neuropathy (HP:0007141)2.02029931
141Muscle stiffness (HP:0003552)2.01394226
142Abnormality of vitamin metabolism (HP:0100508)2.01020748
143Myopathic facies (HP:0002058)2.00572527
144Lethargy (HP:0001254)2.00226030
145Onycholysis (HP:0001806)2.00107823
146Abnormality of the costochondral junction (HP:0000919)1.99918287
147Microvesicular hepatic steatosis (HP:0001414)1.99163165
148Obstructive lung disease (HP:0006536)1.99128447
149Chronic obstructive pulmonary disease (HP:0006510)1.99128447
150Abnormal biliary tract morphology (HP:0012440)1.98224963
151Polygenic inheritance (HP:0010982)1.97976817
152Recurrent gram-negative bacterial infections (HP:0005420)1.95762515
153Dementia (HP:0000726)1.95099497
154Increased IgE level (HP:0003212)1.95046106
155Hyperacusis (HP:0010780)1.94356891
156Milia (HP:0001056)1.93971170
157Cellulitis (HP:0100658)1.93924463
158Abnormal EKG (HP:0003115)1.93677255
159Abnormal urine phosphate concentration (HP:0012599)1.93020343
160Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92937026
161Progressive macrocephaly (HP:0004481)1.92195557
162Cerebral edema (HP:0002181)1.92186140
163Dehydration (HP:0001944)1.91482641
164Increased serum ferritin (HP:0003281)1.90874252
165Seborrheic dermatitis (HP:0001051)1.90769697
166Atelectasis (HP:0100750)1.90213256
167Hypertriglyceridemia (HP:0002155)1.89691891
168Spinal canal stenosis (HP:0003416)1.89605382
169Exercise intolerance (HP:0003546)1.89330548
170Abnormality of the periventricular white matter (HP:0002518)1.89242892
171Abnormality of lateral ventricle (HP:0030047)1.88888556
172Exercise-induced myalgia (HP:0003738)1.88262782
173Vacuolated lymphocytes (HP:0001922)1.88130603
174Fragile skin (HP:0001030)1.88065353
175Xanthomatosis (HP:0000991)1.87145672
176Interstitial pulmonary disease (HP:0006530)1.86931868
177Palpitations (HP:0001962)1.86811942
178Hypobetalipoproteinemia (HP:0003563)1.86193424
179Aplastic anemia (HP:0001915)1.84942045
180Emphysema (HP:0002097)1.83016793
181Diaphragmatic weakness (HP:0009113)1.82047199
182Abnormality of the Achilles tendon (HP:0005109)1.81822196
183Nasal polyposis (HP:0100582)1.81457375
184Prolonged QT interval (HP:0001657)1.80742126
185Visceral angiomatosis (HP:0100761)1.79607127
186Abnormality of sulfur amino acid metabolism (HP:0004339)1.78334386
187Achilles tendon contracture (HP:0001771)1.77891000
188Neurodegeneration (HP:0002180)1.75346263
189Flattened epiphyses (HP:0003071)1.73414471
190Protuberant abdomen (HP:0001538)1.72705330
191Cerebral palsy (HP:0100021)1.70450214
192Orchitis (HP:0100796)1.69574438
193Mutism (HP:0002300)1.68580944
194Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68448257
195Annular pancreas (HP:0001734)1.68042342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.48400858
2FRK4.89175914
3EIF2AK14.27045728
4TRIB34.06171976
5MAP2K63.71012660
6SIK13.26756124
7PRKG22.72668981
8MST1R2.70142114
9MAP2K22.69659235
10TLK12.69165534
11PBK2.54493560
12BUB12.41342604
13STK162.25787476
14TNK22.23721808
15NME12.22440428
16MST42.06559676
17PRPF4B1.97315372
18STK391.88692626
19NME21.88082213
20RIPK41.88041837
21NUAK11.85437168
22TAOK31.83229660
23ERN11.82600870
24TESK21.76385893
25BCKDK1.70231414
26MARK21.69662992
27MAP3K111.68865356
28PIK3CA1.68100615
29ABL21.64192111
30PRKD21.57605662
31MAP3K21.55045167
32RPS6KB21.50663782
33SMG11.48202757
34MAP3K131.43203952
35SIK21.39800660
36MAP3K61.35618481
37FGFR41.34557618
38TTK1.31372964
39ICK1.27919423
40NTRK31.26213430
41MYLK1.24512893
42DAPK21.21832922
43PKN21.15458145
44MAPK121.15191758
45MAP3K81.13882319
46MAP3K121.11601938
47PRKD31.10476785
48CDC42BPA1.07157420
49AURKB1.06525523
50ERBB21.06054739
51RPS6KA21.03467546
52BMX1.01794385
53PDPK11.01109398
54TAOK21.00080889
55TEC0.97540372
56KSR20.97262473
57EPHB20.95729004
58MAP4K10.91779012
59TYK20.90673187
60IRAK20.90635420
61EPHA20.89839849
62SIK30.89316873
63MAP3K10.88285943
64WEE10.87798574
65BLK0.87697674
66GRK60.83976165
67DDR20.83588381
68ZAP700.83279667
69PTK60.83174434
70RPS6KC10.82527006
71RPS6KL10.82527006
72CCNB10.80480909
73MAPK150.80284318
74HIPK20.78882669
75ARAF0.78347566
76IKBKE0.76960254
77TBK10.76844756
78LRRK20.74461898
79DYRK1B0.74393645
80EPHA40.73980943
81TESK10.73925927
82FES0.73420283
83CSK0.73001831
84EPHB10.71207144
85MAPKAPK30.70824669
86PAK40.70217663
87PDK10.70172486
88STK380.69870284
89MAPK70.68726792
90BRSK10.68258903
91RPS6KA60.65928148
92RIPK10.65715753
93GRK10.65476302
94MAP3K140.63912424
95OXSR10.63487901
96IRAK40.63484735
97EEF2K0.63072654
98EIF2AK20.62628109
99CDK190.62348464
100DAPK10.61982646
101MAP2K40.61061974
102MAP3K30.60762465
103LATS10.59736726
104PAK60.59706720
105WNK40.59631815
106MATK0.58835128
107BTK0.57899686
108IRAK30.57211016
109KDR0.56257686
110PIK3CG0.55321974
111MTOR0.54569904
112PIM20.52809319
113CDK60.48813360
114MAPK40.47384254
115MUSK0.47261942
116MAP2K10.46914436
117IKBKB0.46478935
118PRKD10.46316262
119TTN0.45524140
120PRKCH0.44780683
121TYRO30.44351564
122FGR0.43803256
123CHUK0.43509877
124CAMK10.42000558
125MAPK110.41992803
126PLK10.41564460
127CSNK2A20.40752427
128SYK0.39303884
129BRSK20.38667800
130MAPK80.38518856
131PRKCI0.37047919
132RPS6KA10.36667823
133PLK40.35779188
134PASK0.34644100
135CAMK2D0.32679896
136MAP2K30.32545590
137CDK40.31546841
138* PRKCA0.30490018
139TIE10.30431763
140LCK0.29750158
141CAMK2G0.28913435
142CSF1R0.28200989
143PTK20.27404787
144CSNK2A10.27259209
145MAP3K70.25904504
146CAMKK10.25846439
147CSNK1A10.24976447
148JAK20.24575379
149TGFBR20.23869962
150CAMK2B0.23028436
151TAOK10.22550543
152JAK30.21964438
153FLT30.21797356
154MAP3K100.20792719
155MET0.19526992
156AURKA0.18873251
157LYN0.18682092

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.45756785
2Sulfur metabolism_Homo sapiens_hsa009204.18504797
3Ribosome_Homo sapiens_hsa030104.16686834
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.67515562
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83283964
6Oxidative phosphorylation_Homo sapiens_hsa001902.79414327
7Parkinsons disease_Homo sapiens_hsa050122.52660896
8Fat digestion and absorption_Homo sapiens_hsa049752.50919627
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.47023203
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.16778030
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07238239
12Butanoate metabolism_Homo sapiens_hsa006502.05264684
13Notch signaling pathway_Homo sapiens_hsa043302.02232683
14Alzheimers disease_Homo sapiens_hsa050102.00805817
15Chemical carcinogenesis_Homo sapiens_hsa052042.00196383
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93551055
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89705386
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.87612997
19Pentose phosphate pathway_Homo sapiens_hsa000301.82155176
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79924816
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79416664
22Sulfur relay system_Homo sapiens_hsa041221.78878540
23Linoleic acid metabolism_Homo sapiens_hsa005911.73460061
24Staphylococcus aureus infection_Homo sapiens_hsa051501.71602418
25Lysosome_Homo sapiens_hsa041421.70969240
26Huntingtons disease_Homo sapiens_hsa050161.67937970
27Histidine metabolism_Homo sapiens_hsa003401.64683423
28Fatty acid degradation_Homo sapiens_hsa000711.62549888
29Fructose and mannose metabolism_Homo sapiens_hsa000511.52267605
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.49503053
31VEGF signaling pathway_Homo sapiens_hsa043701.48331309
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39742097
33Osteoclast differentiation_Homo sapiens_hsa043801.36527519
34Prion diseases_Homo sapiens_hsa050201.35825409
35Nitrogen metabolism_Homo sapiens_hsa009101.35636167
36Pancreatic secretion_Homo sapiens_hsa049721.35556158
37Retinol metabolism_Homo sapiens_hsa008301.29595709
38Acute myeloid leukemia_Homo sapiens_hsa052211.28739728
39Synaptic vesicle cycle_Homo sapiens_hsa047211.26423545
40Mineral absorption_Homo sapiens_hsa049781.21165996
41Glutathione metabolism_Homo sapiens_hsa004801.20690194
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20167319
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19606248
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18600183
45Folate biosynthesis_Homo sapiens_hsa007901.18566173
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16851925
47GnRH signaling pathway_Homo sapiens_hsa049121.16790011
48Tryptophan metabolism_Homo sapiens_hsa003801.16654020
49Bile secretion_Homo sapiens_hsa049761.14365476
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14297430
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11791369
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11270445
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.08042560
54Complement and coagulation cascades_Homo sapiens_hsa046101.07695907
55Cardiac muscle contraction_Homo sapiens_hsa042601.07673825
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06241873
57B cell receptor signaling pathway_Homo sapiens_hsa046621.05165529
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.04427599
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01462030
60Arachidonic acid metabolism_Homo sapiens_hsa005901.00466944
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00074325
62Tuberculosis_Homo sapiens_hsa051520.99372077
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.99325450
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98474523
65Starch and sucrose metabolism_Homo sapiens_hsa005000.97647267
66Mismatch repair_Homo sapiens_hsa034300.96744397
67Asthma_Homo sapiens_hsa053100.93545788
68Carbon metabolism_Homo sapiens_hsa012000.93091512
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92814136
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92317501
71Allograft rejection_Homo sapiens_hsa053300.91578143
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91344889
73TNF signaling pathway_Homo sapiens_hsa046680.90846424
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89565396
75Insulin resistance_Homo sapiens_hsa049310.88768748
76Toxoplasmosis_Homo sapiens_hsa051450.88554457
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87671500
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.87598103
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87077960
80Estrogen signaling pathway_Homo sapiens_hsa049150.87061411
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.86289636
82DNA replication_Homo sapiens_hsa030300.85508223
83Protein digestion and absorption_Homo sapiens_hsa049740.84851307
84PPAR signaling pathway_Homo sapiens_hsa033200.84315678
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83521916
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.83079729
87beta-Alanine metabolism_Homo sapiens_hsa004100.82559578
88Insulin signaling pathway_Homo sapiens_hsa049100.81353859
89Arginine and proline metabolism_Homo sapiens_hsa003300.81207931
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80516399
91Pyrimidine metabolism_Homo sapiens_hsa002400.77798564
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77668319
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77059192
94Choline metabolism in cancer_Homo sapiens_hsa052310.76040490
95Graft-versus-host disease_Homo sapiens_hsa053320.75929118
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75796193
97Pyruvate metabolism_Homo sapiens_hsa006200.74433867
98Long-term potentiation_Homo sapiens_hsa047200.72363082
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70867452
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70561567
101Homologous recombination_Homo sapiens_hsa034400.70418750
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69722668
103Amoebiasis_Homo sapiens_hsa051460.69635779
104mTOR signaling pathway_Homo sapiens_hsa041500.69570137
105Autoimmune thyroid disease_Homo sapiens_hsa053200.69118826
106Metabolic pathways_Homo sapiens_hsa011000.68458052
107Prolactin signaling pathway_Homo sapiens_hsa049170.67471025
108Propanoate metabolism_Homo sapiens_hsa006400.67358004
109Endocytosis_Homo sapiens_hsa041440.66812788
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64642116
111Rheumatoid arthritis_Homo sapiens_hsa053230.64440370
112AMPK signaling pathway_Homo sapiens_hsa041520.64215934
113Inositol phosphate metabolism_Homo sapiens_hsa005620.63962187
114Gastric acid secretion_Homo sapiens_hsa049710.63255943
115Chronic myeloid leukemia_Homo sapiens_hsa052200.63018246
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.62932636
117Insulin secretion_Homo sapiens_hsa049110.62462327
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62216441
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.61587339
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61396146
121Glycerolipid metabolism_Homo sapiens_hsa005610.61129860
122Galactose metabolism_Homo sapiens_hsa000520.60478209
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60417174
124Collecting duct acid secretion_Homo sapiens_hsa049660.60392229
125Peroxisome_Homo sapiens_hsa041460.60021479
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59898830
127Salmonella infection_Homo sapiens_hsa051320.59076440
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58295440
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57715775
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57536549
131Arginine biosynthesis_Homo sapiens_hsa002200.57292300
132ErbB signaling pathway_Homo sapiens_hsa040120.57043498
133Selenocompound metabolism_Homo sapiens_hsa004500.56687600
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.56038523
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55561833
136Non-small cell lung cancer_Homo sapiens_hsa052230.54962261
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.54738921
138Bladder cancer_Homo sapiens_hsa052190.54018513
139Tight junction_Homo sapiens_hsa045300.53777070
140Platelet activation_Homo sapiens_hsa046110.52932356
141Cocaine addiction_Homo sapiens_hsa050300.50461356
142Glioma_Homo sapiens_hsa052140.47735780
143Ether lipid metabolism_Homo sapiens_hsa005650.47684980
144Amphetamine addiction_Homo sapiens_hsa050310.47287730
145Vibrio cholerae infection_Homo sapiens_hsa051100.46127843
146Type I diabetes mellitus_Homo sapiens_hsa049400.45781818
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45781608
148Hepatitis C_Homo sapiens_hsa051600.45468548
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45035676
150Renin secretion_Homo sapiens_hsa049240.44427121
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.44274991
152Glucagon signaling pathway_Homo sapiens_hsa049220.44273038
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43150634
154Caffeine metabolism_Homo sapiens_hsa002320.42415839
155MAPK signaling pathway_Homo sapiens_hsa040100.42020516
156Renin-angiotensin system_Homo sapiens_hsa046140.40816785
157Fatty acid elongation_Homo sapiens_hsa000620.40658707
158Biosynthesis of amino acids_Homo sapiens_hsa012300.39507657
159N-Glycan biosynthesis_Homo sapiens_hsa005100.38994466
160ABC transporters_Homo sapiens_hsa020100.38021065
161Other glycan degradation_Homo sapiens_hsa005110.37752426
162Thyroid cancer_Homo sapiens_hsa052160.31790897
163Fatty acid metabolism_Homo sapiens_hsa012120.29635523
164Vitamin digestion and absorption_Homo sapiens_hsa049770.28642828
165Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27480500
166RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27277676
167Protein export_Homo sapiens_hsa030600.24895331
168Tyrosine metabolism_Homo sapiens_hsa003500.24001957
169Purine metabolism_Homo sapiens_hsa002300.23651366
170Influenza A_Homo sapiens_hsa051640.21108125
171Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18943522
172Pertussis_Homo sapiens_hsa051330.18315964
173Base excision repair_Homo sapiens_hsa034100.18246388
174Systemic lupus erythematosus_Homo sapiens_hsa053220.17016096
175Leishmaniasis_Homo sapiens_hsa051400.16655892
176Legionellosis_Homo sapiens_hsa051340.16313042
177Phenylalanine metabolism_Homo sapiens_hsa003600.15129119

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