NOXRED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.99669551
2fusion of sperm to egg plasma membrane (GO:0007342)8.04260932
3cell wall macromolecule catabolic process (GO:0016998)8.03656888
4cell wall macromolecule metabolic process (GO:0044036)8.03656888
5sperm-egg recognition (GO:0035036)8.02185941
6binding of sperm to zona pellucida (GO:0007339)7.43313157
7acrosome reaction (GO:0007340)7.28651470
8cell-cell recognition (GO:0009988)7.25058442
9spermatid development (GO:0007286)7.07300914
10multicellular organism reproduction (GO:0032504)6.75138188
11acrosome assembly (GO:0001675)6.31965284
12axonemal dynein complex assembly (GO:0070286)6.30387607
13epithelial cilium movement (GO:0003351)6.22909450
14plasma membrane fusion (GO:0045026)6.19282242
15piRNA metabolic process (GO:0034587)6.14072452
16cilium or flagellum-dependent cell motility (GO:0001539)5.99631031
17motile cilium assembly (GO:0044458)5.95435927
18regulation of cilium movement (GO:0003352)5.91157052
19synaptonemal complex assembly (GO:0007130)5.88498695
20microtubule depolymerization (GO:0007019)5.78307308
21reproduction (GO:0000003)5.69517001
22synaptonemal complex organization (GO:0070193)5.63610006
23male meiosis (GO:0007140)5.44087065
24regulation of meiosis I (GO:0060631)5.38190211
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.25187584
26negative regulation of fibroblast apoptotic process (GO:2000270)4.88271462
27negative regulation of inclusion body assembly (GO:0090084)4.78633794
28spermatogenesis (GO:0007283)4.75837535
29male gamete generation (GO:0048232)4.74757478
30DNA packaging (GO:0006323)4.73204976
31cilium movement (GO:0003341)4.70022836
32chromosome condensation (GO:0030261)4.63120625
33single fertilization (GO:0007338)4.62417440
34somatic diversification of immune receptors via somatic mutation (GO:0002566)4.62187371
35somatic hypermutation of immunoglobulin genes (GO:0016446)4.62187371
36DNA deamination (GO:0045006)4.58644990
37gamete generation (GO:0007276)4.36006020
38chromosome organization involved in meiosis (GO:0070192)4.34001796
39male meiosis I (GO:0007141)4.32645287
40axoneme assembly (GO:0035082)4.31200667
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.24777216
42meiotic nuclear division (GO:0007126)4.22291538
43protein K11-linked deubiquitination (GO:0035871)4.20443209
44regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.12410082
45fucose catabolic process (GO:0019317)4.11866482
46L-fucose metabolic process (GO:0042354)4.11866482
47L-fucose catabolic process (GO:0042355)4.11866482
48regulation of inclusion body assembly (GO:0090083)4.10969684
49protein-cofactor linkage (GO:0018065)4.10601768
50fertilization (GO:0009566)4.08218884
51germ cell development (GO:0007281)4.07586518
52DNA methylation involved in gamete generation (GO:0043046)4.02526189
53sperm capacitation (GO:0048240)3.96928439
54righting reflex (GO:0060013)3.94142166
55single strand break repair (GO:0000012)3.85081054
56reflex (GO:0060004)3.82738957
57behavioral response to nicotine (GO:0035095)3.82060096
58sphingosine metabolic process (GO:0006670)3.80390487
59neurotransmitter-gated ion channel clustering (GO:0072578)3.78270722
60meiosis I (GO:0007127)3.78186529
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.76946401
62interkinetic nuclear migration (GO:0022027)3.76490332
63organic cation transport (GO:0015695)3.75437821
64snRNA processing (GO:0016180)3.72501907
65chaperone-mediated protein complex assembly (GO:0051131)3.69386423
66sphingoid metabolic process (GO:0046519)3.68717093
67diol metabolic process (GO:0034311)3.65847289
68DNA replication-dependent nucleosome assembly (GO:0006335)3.63623296
69DNA replication-dependent nucleosome organization (GO:0034723)3.63623296
70regulation of fibroblast apoptotic process (GO:2000269)3.62400288
71cellular anion homeostasis (GO:0030002)3.61392200
72nuclear pore organization (GO:0006999)3.51560157
73regulation of spindle checkpoint (GO:0090231)3.51354729
74histone exchange (GO:0043486)3.51224887
75photoreceptor cell maintenance (GO:0045494)3.50971477
76nuclear pore complex assembly (GO:0051292)3.50558483
77centriole replication (GO:0007099)3.50085227
78regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.49740516
79regulation of centriole replication (GO:0046599)3.46280452
80platelet dense granule organization (GO:0060155)3.45611281
81positive regulation of meiosis (GO:0045836)3.43238855
82regulation of histone H3-K9 methylation (GO:0051570)3.39167038
83necroptotic process (GO:0070266)3.35252833
84growth hormone receptor signaling pathway (GO:0060396)3.33850469
85protein localization to chromosome, centromeric region (GO:0071459)3.33792675
86positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.32011940
87multicellular organismal reproductive process (GO:0048609)3.31936636
88regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.31663049
89meiotic cell cycle process (GO:1903046)3.31339965
90DNA replication initiation (GO:0006270)3.28156903
91regulation of microtubule-based movement (GO:0060632)3.27526355
92calcium ion-dependent exocytosis (GO:0017156)3.27238134
93sequestering of actin monomers (GO:0042989)3.24459229
94nucleus organization (GO:0006997)3.22738792
95microtubule severing (GO:0051013)3.22445900
96cell recognition (GO:0008037)3.22380688
97DNA demethylation (GO:0080111)3.20634569
98adaptation of signaling pathway (GO:0023058)3.20244549
99left/right axis specification (GO:0070986)3.19891734
100thyroid hormone generation (GO:0006590)3.18589096
101positive regulation of meiotic cell cycle (GO:0051446)3.17765706
102thyroid hormone metabolic process (GO:0042403)3.16713082
103mitotic nuclear envelope disassembly (GO:0007077)3.13490407
104protein neddylation (GO:0045116)3.12618187
105interferon-gamma secretion (GO:0072643)3.12203735
106indole-containing compound catabolic process (GO:0042436)3.11316667
107indolalkylamine catabolic process (GO:0046218)3.11316667
108tryptophan catabolic process (GO:0006569)3.11316667
109indolalkylamine metabolic process (GO:0006586)3.11185250
110postsynaptic membrane organization (GO:0001941)3.11025820
111mitotic sister chromatid cohesion (GO:0007064)3.09677241
112reciprocal DNA recombination (GO:0035825)3.09479175
113reciprocal meiotic recombination (GO:0007131)3.09479175
114DNA strand elongation involved in DNA replication (GO:0006271)3.09417083
115ventricular system development (GO:0021591)3.08487184
116regulation of rhodopsin mediated signaling pathway (GO:0022400)3.05531927
117positive regulation of cell fate commitment (GO:0010455)3.05521388
118snRNA metabolic process (GO:0016073)3.03541938
119positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.02032072
120cellular response to growth hormone stimulus (GO:0071378)2.99392572
121mitotic metaphase plate congression (GO:0007080)2.97204690
122membrane disassembly (GO:0030397)2.96984671
123nuclear envelope disassembly (GO:0051081)2.96984671
124cytidine deamination (GO:0009972)2.96644045
125cytidine metabolic process (GO:0046087)2.96644045
126cytidine catabolic process (GO:0006216)2.96644045
127meiotic cell cycle (GO:0051321)2.95998659
128seminiferous tubule development (GO:0072520)2.94561973
129telomere maintenance via semi-conservative replication (GO:0032201)2.92782722
130negative regulation of gene silencing (GO:0060969)2.92668345
131response to pheromone (GO:0019236)2.92273082
132rhodopsin mediated signaling pathway (GO:0016056)2.92132754
133chromatin silencing (GO:0006342)2.92026908
134formation of translation preinitiation complex (GO:0001731)2.90130909
135neural tube formation (GO:0001841)2.89941100
136microtubule polymerization or depolymerization (GO:0031109)2.89888997
137DNA strand elongation (GO:0022616)2.89674591
138monoubiquitinated protein deubiquitination (GO:0035520)2.88783854
139gene silencing by RNA (GO:0031047)2.88669034
140protein K6-linked ubiquitination (GO:0085020)2.88411241
141RNA destabilization (GO:0050779)2.86478632
142retinal rod cell development (GO:0046548)2.80273528
143heterochromatin organization (GO:0070828)2.77478722
144exogenous drug catabolic process (GO:0042738)2.77283178
145negative regulation of osteoblast proliferation (GO:0033689)2.77232363
146retinal cone cell development (GO:0046549)2.75454630
147behavioral response to ethanol (GO:0048149)2.74439125
148cilium organization (GO:0044782)2.74067356
149regulation of mesoderm development (GO:2000380)2.73989578
150serotonin receptor signaling pathway (GO:0007210)2.73947959
151DNA conformation change (GO:0071103)2.72805127
152centriole assembly (GO:0098534)2.72076935
153pore complex assembly (GO:0046931)2.71874701
154kynurenine metabolic process (GO:0070189)2.71792976
155protein complex localization (GO:0031503)2.71789424
156synapsis (GO:0007129)2.71451760
157intracellular pH reduction (GO:0051452)2.71082453
158negative regulation of histone methylation (GO:0031061)2.70725933
159chromosome organization (GO:0051276)2.70664403
160cellular ketone body metabolic process (GO:0046950)2.69954463
161preassembly of GPI anchor in ER membrane (GO:0016254)2.69842982
162regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69304814
163positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69304814
164ribosome assembly (GO:0042255)2.67308223
165negative regulation of systemic arterial blood pressure (GO:0003085)2.65687978
166regulation of collateral sprouting (GO:0048670)2.65295098
167chromatin remodeling at centromere (GO:0031055)2.64605124
168drug catabolic process (GO:0042737)2.64547478
169cilium assembly (GO:0042384)2.63773066
170glycolipid biosynthetic process (GO:0009247)2.63393009
171regulation of telomere maintenance via telomerase (GO:0032210)2.63275375
172DNA replication checkpoint (GO:0000076)2.63098590
173sulfation (GO:0051923)2.63056335
174neuronal action potential propagation (GO:0019227)2.62438538
175protein deneddylation (GO:0000338)2.62033138
176somite rostral/caudal axis specification (GO:0032525)2.61246252
177detection of light stimulus involved in visual perception (GO:0050908)2.57884501
178detection of light stimulus involved in sensory perception (GO:0050962)2.57884501
179glycosphingolipid biosynthetic process (GO:0006688)2.56645765
180negative regulation of mast cell activation (GO:0033004)2.54497301
181peptidyl-histidine modification (GO:0018202)2.52633316
182purinergic nucleotide receptor signaling pathway (GO:0035590)2.50733101
183meiotic chromosome segregation (GO:0045132)2.50193217
184detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47350650
185inner ear receptor stereocilium organization (GO:0060122)2.47186955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.68518286
2E2F7_22180533_ChIP-Seq_HELA_Human5.84315674
3EZH2_22144423_ChIP-Seq_EOC_Human4.09255411
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.46632742
5ZNF274_21170338_ChIP-Seq_K562_Hela3.12302691
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78858127
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78716231
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77567366
9GBX2_23144817_ChIP-Seq_PC3_Human2.71259217
10IGF1R_20145208_ChIP-Seq_DFB_Human2.63612703
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48165093
12TAF15_26573619_Chip-Seq_HEK293_Human2.46821273
13ER_23166858_ChIP-Seq_MCF-7_Human2.44713857
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34229673
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34169160
16P300_19829295_ChIP-Seq_ESCs_Human2.24550259
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21686584
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19725343
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16470908
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.15562430
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13770290
22VDR_22108803_ChIP-Seq_LS180_Human2.10694658
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09869910
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.05321327
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.04130806
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02653552
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99428420
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98091159
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90872856
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89275420
31FUS_26573619_Chip-Seq_HEK293_Human1.84606430
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.84557775
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82756996
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78851174
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78579028
36CBP_20019798_ChIP-Seq_JUKART_Human1.78579028
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72818093
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72409715
39EWS_26573619_Chip-Seq_HEK293_Human1.71115941
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64928697
41SMAD4_21799915_ChIP-Seq_A2780_Human1.64809834
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64485962
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61989408
44STAT3_23295773_ChIP-Seq_U87_Human1.61486530
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60606782
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57995817
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.57581684
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.57231639
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55723999
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55079321
51BCAT_22108803_ChIP-Seq_LS180_Human1.55057506
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54459714
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54319470
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53172317
55TCF4_23295773_ChIP-Seq_U87_Human1.51849151
56AR_21572438_ChIP-Seq_LNCaP_Human1.51436463
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.51421327
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51233769
59AR_25329375_ChIP-Seq_VCAP_Human1.49320314
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48769357
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48575232
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.48328479
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47856056
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47828414
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46740335
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44241125
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.43291518
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42385667
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.41939869
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.39812618
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38839034
72TCF4_22108803_ChIP-Seq_LS180_Human1.38795937
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38594840
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37788830
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37788830
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37342502
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.37342502
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35650032
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35547541
80CDX2_22108803_ChIP-Seq_LS180_Human1.35326285
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.34531981
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.34357601
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33402892
84EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32325253
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32182520
86NANOG_19829295_ChIP-Seq_ESCs_Human1.32145368
87SOX2_19829295_ChIP-Seq_ESCs_Human1.32145368
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.30321385
89P53_22387025_ChIP-Seq_ESCs_Mouse1.28599265
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28030156
91RUNX2_22187159_ChIP-Seq_PCA_Human1.27786868
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.26952481
93TP53_22573176_ChIP-Seq_HFKS_Human1.24811076
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.23195210
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21875029
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21158304
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.21078897
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20269172
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19937978
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19246988
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.19015964
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18593054
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.17589850
104CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17370098
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16375129
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16091781
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.15599395
108AR_21909140_ChIP-Seq_LNCAP_Human1.14881414
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14648010
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.13995015
111GATA3_21867929_ChIP-Seq_CD8_Mouse1.13462288
112FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13443865
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12860804
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12834877
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.12488512
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12229508
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11885328
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11685886
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.11039279
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10299043
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09523817
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09331309
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08833393
124P300_18555785_Chip-Seq_ESCs_Mouse1.08703048
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.08508418
126HOXB7_26014856_ChIP-Seq_BT474_Human1.07916530
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.07022229
128ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06445534
129NCOR_22424771_ChIP-Seq_293T_Human1.05731934
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.04436639
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03653618
132ETV1_20927104_ChIP-Seq_GIST48_Human1.03606917
133TET1_21451524_ChIP-Seq_MESCs_Mouse1.03543398
134CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03422717
135NFYA_21822215_ChIP-Seq_K562_Human1.03335228
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.03206950
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03111664
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02991708
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02911796
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02717158
141YY1_22570637_ChIP-Seq_MALME-3M_Human1.02709640
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02203125
143FOXP3_21729870_ChIP-Seq_TREG_Human1.02055177
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01871488
145HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01503745
146GATA3_21878914_ChIP-Seq_MCF-7_Human1.01294627
147PHF8_20622853_ChIP-Seq_HELA_Human1.00061643
148AR_20517297_ChIP-Seq_VCAP_Human0.99756677
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.99579661
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99157024
151TBL1_22424771_ChIP-Seq_293T_Human0.98872431
152KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97140267
153EGR1_19374776_ChIP-ChIP_THP-1_Human0.96775350
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.96680432
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96524165
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95514897
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94890201
158VDR_23849224_ChIP-Seq_CD4+_Human0.94679220
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94629059
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94561057
161GATA3_21867929_ChIP-Seq_TH1_Mouse0.94302935
162PHF8_20622854_ChIP-Seq_HELA_Human0.93105533
163XRN2_22483619_ChIP-Seq_HELA_Human0.93040473
164KAP1_27257070_Chip-Seq_ESCs_Mouse0.93005213
165MYC_22102868_ChIP-Seq_BL_Human0.92652987
166NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90432846
167LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.90386662
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90329852
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89344335
170FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89256621
171GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.88786340
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88775683
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87804685
174SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87389504
175TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87301108
176KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87231251
177KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86748231
178RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85500490
179RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85263356
180EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85012657
181IRF8_22096565_ChIP-ChIP_GC-B_Human0.84482145
182POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84412170
183CTCF_26484167_Chip-Seq_Bcells_Mouse0.83968655
184TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83164193
185MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82898442
186STAT1_17558387_ChIP-Seq_HELA_Human0.81136764
187PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79515382
188BCOR_27268052_Chip-Seq_Bcells_Human0.79168938
189MYB_26560356_Chip-Seq_TH1_Human0.77303467
190ELF1_20517297_ChIP-Seq_JURKAT_Human0.77217433
191GABP_19822575_ChIP-Seq_HepG2_Human0.76814511
192KDM5A_27292631_Chip-Seq_BREAST_Human0.76462290
193PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75409190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001929_abnormal_gametogenesis4.24538089
2MP0003698_abnormal_male_reproductive4.22499636
3MP0008877_abnormal_DNA_methylation4.20164892
4MP0002837_dystrophic_cardiac_calcinosis3.97017977
5MP0003693_abnormal_embryo_hatching3.72500284
6MP0010094_abnormal_chromosome_stability3.53644120
7MP0003111_abnormal_nucleus_morphology3.52933699
8MP0002234_abnormal_pharynx_morphology3.41594567
9MP0004885_abnormal_endolymph3.10034669
10MP0002138_abnormal_hepatobiliary_system3.00263355
11MP0000569_abnormal_digit_pigmentation2.82322899
12MP0002210_abnormal_sex_determination2.80075712
13MP0003195_calcinosis2.76002173
14MP0008058_abnormal_DNA_repair2.75866893
15MP0004957_abnormal_blastocyst_morpholog2.74306939
16MP0003646_muscle_fatigue2.66506122
17MP0001485_abnormal_pinna_reflex2.55919175
18MP0003136_yellow_coat_color2.51846046
19MP0001145_abnormal_male_reproductive2.49855378
20MP0002161_abnormal_fertility/fecundity2.44787479
21MP0003077_abnormal_cell_cycle2.38396681
22MP0008057_abnormal_DNA_replication2.31709288
23MP0005084_abnormal_gallbladder_morpholo2.19032950
24MP0005365_abnormal_bile_salt2.16684341
25MP0004742_abnormal_vestibular_system2.06933393
26MP0000653_abnormal_sex_gland2.06814669
27MP0005410_abnormal_fertilization10.5473886
28MP0002876_abnormal_thyroid_physiology1.99865979
29MP0008872_abnormal_physiological_respon1.97543982
30MP0005670_abnormal_white_adipose1.96407097
31MP0003123_paternal_imprinting1.96093507
32MP0005646_abnormal_pituitary_gland1.94228488
33MP0003252_abnormal_bile_duct1.84443684
34MP0005085_abnormal_gallbladder_physiolo1.83521855
35MP0005551_abnormal_eye_electrophysiolog1.77493125
36MP0000383_abnormal_hair_follicle1.75421958
37MP0002653_abnormal_ependyma_morphology1.67862638
38MP0003806_abnormal_nucleotide_metabolis1.66981560
39MP0008875_abnormal_xenobiotic_pharmacok1.63817301
40MP0005377_hearing/vestibular/ear_phenot1.61806308
41MP0003878_abnormal_ear_physiology1.61806308
42MP0001486_abnormal_startle_reflex1.61120218
43MP0002160_abnormal_reproductive_system1.61016210
44MP0001529_abnormal_vocalization1.58947391
45MP0001835_abnormal_antigen_presentation1.53109415
46MP0001986_abnormal_taste_sensitivity1.50975935
47MP0003786_premature_aging1.50418562
48MP0001968_abnormal_touch/_nociception1.50083303
49MP0001730_embryonic_growth_arrest1.49954696
50MP0003890_abnormal_embryonic-extraembry1.49172850
51MP0004145_abnormal_muscle_electrophysio1.48886353
52MP0005075_abnormal_melanosome_morpholog1.47354178
53MP0002928_abnormal_bile_duct1.46453288
54MP0002736_abnormal_nociception_after1.44397968
55MP0000613_abnormal_salivary_gland1.41724569
56MP0004043_abnormal_pH_regulation1.40773127
57MP0004133_heterotaxia1.40435814
58MP0004147_increased_porphyrin_level1.40192210
59MP0001800_abnormal_humoral_immune1.39314892
60MP0005397_hematopoietic_system_phenotyp1.38788794
61MP0001545_abnormal_hematopoietic_system1.38788794
62MP0008995_early_reproductive_senescence1.38557715
63MP0009745_abnormal_behavioral_response1.37777066
64MP0000631_abnormal_neuroendocrine_gland1.35925348
65MP0000427_abnormal_hair_cycle1.33859579
66MP0002272_abnormal_nervous_system1.33200496
67MP0001873_stomach_inflammation1.30328663
68MP0002938_white_spotting1.26693640
69MP0005645_abnormal_hypothalamus_physiol1.26162339
70MP0001501_abnormal_sleep_pattern1.24039768
71MP0006292_abnormal_olfactory_placode1.23948471
72MP0002638_abnormal_pupillary_reflex1.23406853
73MP0008260_abnormal_autophagy1.20449837
74MP0009278_abnormal_bone_marrow1.19676842
75MP0003787_abnormal_imprinting1.19449518
76MP0000350_abnormal_cell_proliferation1.18141587
77MP0009764_decreased_sensitivity_to1.17979362
78MP0003045_fibrosis1.17695013
79MP0005253_abnormal_eye_physiology1.16262750
80MP0006072_abnormal_retinal_apoptosis1.15764605
81MP0005367_renal/urinary_system_phenotyp1.15633993
82MP0000516_abnormal_urinary_system1.15633993
83MP0002572_abnormal_emotion/affect_behav1.14119624
84MP0000313_abnormal_cell_death1.13770090
85MP0005310_abnormal_salivary_gland1.12352306
86MP0002229_neurodegeneration1.12319117
87MP0000015_abnormal_ear_pigmentation1.12151913
88MP0002735_abnormal_chemical_nociception1.10154117
89MP0000358_abnormal_cell_content/1.09869614
90MP0002452_abnormal_antigen_presenting1.09249262
91MP0002102_abnormal_ear_morphology1.08381408
92MP0002398_abnormal_bone_marrow1.06326701
93MP0001963_abnormal_hearing_physiology1.06233569
94MP0008932_abnormal_embryonic_tissue1.06200419
95MP0002277_abnormal_respiratory_mucosa1.05197897
96MP0001984_abnormal_olfaction1.02402817
97MP0004808_abnormal_hematopoietic_stem1.01640184
98MP0001790_abnormal_immune_system1.01159502
99MP0005387_immune_system_phenotype1.01159502
100MP0010307_abnormal_tumor_latency0.99671384
101MP0008007_abnormal_cellular_replicative0.99011981
102MP0000372_irregular_coat_pigmentation0.98948773
103MP0003303_peritoneal_inflammation0.98762860
104MP0005389_reproductive_system_phenotype0.98140858
105MP0006276_abnormal_autonomic_nervous0.97354488
106MP0000689_abnormal_spleen_morphology0.96497376
107MP0002751_abnormal_autonomic_nervous0.95790632
108MP0003635_abnormal_synaptic_transmissio0.95571718
109MP0002723_abnormal_immune_serum0.92572821
110MP0001672_abnormal_embryogenesis/_devel0.92028348
111MP0005380_embryogenesis_phenotype0.92028348
112MP0010386_abnormal_urinary_bladder0.91908706
113MP0003718_maternal_effect0.91880593
114MP0010678_abnormal_skin_adnexa0.90260747
115MP0001697_abnormal_embryo_size0.90237387
116MP0002420_abnormal_adaptive_immunity0.87851571
117MP0001905_abnormal_dopamine_level0.87784714
118MP0000026_abnormal_inner_ear0.87455560
119MP0005171_absent_coat_pigmentation0.86196350
120MP0008961_abnormal_basal_metabolism0.85981343
121MP0001819_abnormal_immune_cell0.84953479
122MP0004142_abnormal_muscle_tone0.83656285
123MP0002254_reproductive_system_inflammat0.83516674
124MP0002019_abnormal_tumor_incidence0.83398545
125MP0002080_prenatal_lethality0.81118546
126MP0003315_abnormal_perineum_morphology0.80572105
127MP0002067_abnormal_sensory_capabilities0.80543045
128MP0005384_cellular_phenotype0.80036265
129MP0005423_abnormal_somatic_nervous0.79945822
130MP0003984_embryonic_growth_retardation0.79108024
131MP0005621_abnormal_cell_physiology0.78418307
132MP0004924_abnormal_behavior0.78157028
133MP0005386_behavior/neurological_phenoty0.78157028
134MP0000716_abnormal_immune_system0.77210744
135MP0001765_abnormal_ion_homeostasis0.76941538
136MP0000685_abnormal_immune_system0.76408670
137MP0002722_abnormal_immune_system0.76329217
138MP0002088_abnormal_embryonic_growth/wei0.75192265
139MP0002429_abnormal_blood_cell0.74634307
140MP0005195_abnormal_posterior_eye0.74589236
141MP0002168_other_aberrant_phenotype0.72787110
142MP0001853_heart_inflammation0.71373672
143MP0003633_abnormal_nervous_system0.71266483
144MP0009765_abnormal_xenobiotic_induced0.71097380
145MP0010352_gastrointestinal_tract_polyps0.71050752
146MP0005360_urolithiasis0.70475541
147MP0003091_abnormal_cell_migration0.70154725
148MP0006054_spinal_hemorrhage0.69992041
149MP0010329_abnormal_lipoprotein_level0.69781965
150MP0002557_abnormal_social/conspecific_i0.69393933
151MP0005187_abnormal_penis_morphology0.69138390
152MP0000647_abnormal_sebaceous_gland0.68764100
153MP0005000_abnormal_immune_tolerance0.68702017
154MP0006082_CNS_inflammation0.68003617
155MP0003699_abnormal_female_reproductive0.65129277
156MP0000703_abnormal_thymus_morphology0.64659550
157MP0002085_abnormal_embryonic_tissue0.64436433
158MP0003121_genomic_imprinting0.63156263
159MP0002086_abnormal_extraembryonic_tissu0.63092520
160MP0005671_abnormal_response_to0.63018363
161MP0004197_abnormal_fetal_growth/weight/0.62642444
162MP0003879_abnormal_hair_cell0.62167186
163MP0002405_respiratory_system_inflammati0.59633388
164MP0002084_abnormal_developmental_patter0.59228172
165MP0002396_abnormal_hematopoietic_system0.59122285
166MP0009333_abnormal_splenocyte_physiolog0.58821701
167MP0002419_abnormal_innate_immunity0.58736316
168MP0001764_abnormal_homeostasis0.56708891
169MP0008770_decreased_survivor_rate0.56393351
170MP0001293_anophthalmia0.56131038
171MP0005076_abnormal_cell_differentiation0.55935610
172MP0005174_abnormal_tail_pigmentation0.55621043
173MP0009672_abnormal_birth_weight0.54903277
174MP0004859_abnormal_synaptic_plasticity0.54548050
175MP0003436_decreased_susceptibility_to0.52886310
176MP0003172_abnormal_lysosome_physiology0.51060468
177MP0009046_muscle_twitch0.51026252
178MP0003566_abnormal_cell_adhesion0.49808285
179MP0006035_abnormal_mitochondrial_morpho0.49424381

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.07375758
2Absent/shortened dynein arms (HP:0200106)8.82916309
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.82916309
4Abnormal respiratory epithelium morphology (HP:0012253)6.35626360
5Abnormal respiratory motile cilium morphology (HP:0005938)6.35626360
6Abnormal respiratory motile cilium physiology (HP:0012261)5.72390487
7Rhinitis (HP:0012384)5.42697125
8Chronic bronchitis (HP:0004469)5.31954254
9Infertility (HP:0000789)4.90917396
10Bronchitis (HP:0012387)4.52733024
11Nasal polyposis (HP:0100582)4.42711197
12Toxemia of pregnancy (HP:0100603)4.36715428
13Impulsivity (HP:0100710)4.25128895
14Recurrent sinusitis (HP:0011108)4.12688649
15Recurrent bronchitis (HP:0002837)3.99918870
16Abnormal ciliary motility (HP:0012262)3.96372938
17Pancreatic cysts (HP:0001737)3.92434621
18Gaze-evoked nystagmus (HP:0000640)3.84418353
19Abnormality of the renal cortex (HP:0011035)3.72344770
20Recurrent otitis media (HP:0000403)3.63992588
21Abnormal spermatogenesis (HP:0008669)3.63218464
22Nephronophthisis (HP:0000090)3.56469886
23Carpal bone hypoplasia (HP:0001498)3.46265856
24Medial flaring of the eyebrow (HP:0010747)3.40696082
25Abnormality of the nasal mucosa (HP:0000433)3.39105495
26Male infertility (HP:0003251)3.38340167
27Bronchiectasis (HP:0002110)3.29525859
28Autoimmune thrombocytopenia (HP:0001973)3.19167717
29Amelogenesis imperfecta (HP:0000705)3.14874497
30Pancreatic fibrosis (HP:0100732)3.13637500
31Hypoplasia of the capital femoral epiphysis (HP:0003090)3.08178391
32True hermaphroditism (HP:0010459)3.03885031
33Constricted visual fields (HP:0001133)2.99628906
34Abolished electroretinogram (ERG) (HP:0000550)2.95036127
35Attenuation of retinal blood vessels (HP:0007843)2.94661518
36Hyperventilation (HP:0002883)2.92581373
37Abnormality of macular pigmentation (HP:0008002)2.91046037
38Birth length less than 3rd percentile (HP:0003561)2.86317073
39Volvulus (HP:0002580)2.83284532
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.72878569
41Absent epiphyses (HP:0010577)2.72878569
42Absent thumb (HP:0009777)2.72305777
43Small epiphyses (HP:0010585)2.71643632
44Increased IgM level (HP:0003496)2.61613471
45Large for gestational age (HP:0001520)2.59714424
46Abnormality of the renal medulla (HP:0100957)2.59269377
47Abnormal rod and cone electroretinograms (HP:0008323)2.57808550
48Abnormal drinking behavior (HP:0030082)2.55723579
49Polydipsia (HP:0001959)2.55723579
50Agnosia (HP:0010524)2.53757478
51Genetic anticipation (HP:0003743)2.53038952
52Abnormality of midbrain morphology (HP:0002418)2.52142702
53Molar tooth sign on MRI (HP:0002419)2.52142702
54Decreased circulating renin level (HP:0003351)2.51879149
55Tubulointerstitial nephritis (HP:0001970)2.51116170
56Meckel diverticulum (HP:0002245)2.49557650
57Insulin-resistant diabetes mellitus (HP:0000831)2.48785422
58Breast hypoplasia (HP:0003187)2.46818192
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46756870
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45318227
61Spinal muscular atrophy (HP:0007269)2.45226955
62Autoimmune hemolytic anemia (HP:0001890)2.42927237
63Azoospermia (HP:0000027)2.42789157
64Congenital stationary night blindness (HP:0007642)2.41183217
65Stomatitis (HP:0010280)2.37801688
66Focal motor seizures (HP:0011153)2.37562914
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.37528623
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37482300
69Abnormality of the preputium (HP:0100587)2.37312831
70Neonatal hypoglycemia (HP:0001998)2.36226215
71Ependymoma (HP:0002888)2.34952394
72Myelodysplasia (HP:0002863)2.34421111
73Aplasia/hypoplasia of the humerus (HP:0006507)2.33394497
74Abnormality of the ileum (HP:0001549)2.32493321
75Thyroid-stimulating hormone excess (HP:0002925)2.32459139
76Nephrogenic diabetes insipidus (HP:0009806)2.32055622
77Congenital primary aphakia (HP:0007707)2.29830605
78Disproportionate short-trunk short stature (HP:0003521)2.28457117
79Short humerus (HP:0005792)2.26230785
80Chromsome breakage (HP:0040012)2.24089002
81Bony spicule pigmentary retinopathy (HP:0007737)2.23556504
82Gait imbalance (HP:0002141)2.23397613
83Hypochromic anemia (HP:0001931)2.21974361
84Degeneration of anterior horn cells (HP:0002398)2.21486799
85Abnormality of the anterior horn cell (HP:0006802)2.21486799
86Progressive cerebellar ataxia (HP:0002073)2.21228725
87Bile duct proliferation (HP:0001408)2.20484104
88Abnormal biliary tract physiology (HP:0012439)2.20484104
89Epileptic encephalopathy (HP:0200134)2.19042560
90Tubular atrophy (HP:0000092)2.15777889
91Supernumerary spleens (HP:0009799)2.14976097
92Abnormality of chromosome stability (HP:0003220)2.14910776
93Retinal dysplasia (HP:0007973)2.14166417
94Chronic sinusitis (HP:0011109)2.13947898
95Cystic liver disease (HP:0006706)2.12008750
96Flattened epiphyses (HP:0003071)2.10759649
97Broad-based gait (HP:0002136)2.10538350
98Irregular epiphyses (HP:0010582)2.07253012
99Genital tract atresia (HP:0001827)2.06411338
100Agammaglobulinemia (HP:0004432)2.06310700
101Abnormality of the nasal septum (HP:0000419)2.04535272
102Short ribs (HP:0000773)2.00848222
103Bone marrow hypocellularity (HP:0005528)1.99717358
104Astrocytoma (HP:0009592)1.99494003
105Abnormality of the astrocytes (HP:0100707)1.99494003
106Widely spaced teeth (HP:0000687)1.98448633
107Cupped ear (HP:0000378)1.97571806
108Polyuria (HP:0000103)1.95122115
109Glioma (HP:0009733)1.94236401
110Muscle hypertrophy of the lower extremities (HP:0008968)1.94201523
111Retinitis pigmentosa (HP:0000510)1.93983923
112Eosinophilia (HP:0001880)1.93882190
113Depressed nasal tip (HP:0000437)1.92910518
114Abnormality of the lower motor neuron (HP:0002366)1.92770032
115Ectopic kidney (HP:0000086)1.90855377
116Vaginal atresia (HP:0000148)1.90407504
117Neonatal respiratory distress (HP:0002643)1.88882322
118Recurrent lower respiratory tract infections (HP:0002783)1.87621935
119Renal cortical cysts (HP:0000803)1.85197668
120Leukopenia (HP:0001882)1.84622602
121Thrombocytosis (HP:0001894)1.81744623
122Sloping forehead (HP:0000340)1.81460876
123Recurrent pneumonia (HP:0006532)1.80845493
124Global brain atrophy (HP:0002283)1.78713279
125Pendular nystagmus (HP:0012043)1.78601776
126Congenital sensorineural hearing impairment (HP:0008527)1.75957004
127Abnormality of the labia minora (HP:0012880)1.75848545
128Abnormality of eosinophils (HP:0001879)1.74948134
129Myotonia (HP:0002486)1.74144909
130Febrile seizures (HP:0002373)1.72981053
131Small intestinal stenosis (HP:0012848)1.72884849
132Duodenal stenosis (HP:0100867)1.72884849
133Parakeratosis (HP:0001036)1.72501389
134Facial cleft (HP:0002006)1.71616179
135Tubulointerstitial fibrosis (HP:0005576)1.71344531
136Hypomagnesemia (HP:0002917)1.70635035
137Congenital hepatic fibrosis (HP:0002612)1.70453015
138Short femoral neck (HP:0100864)1.70186086
13911 pairs of ribs (HP:0000878)1.69684559
140Abnormality of the carotid arteries (HP:0005344)1.69421832
141Furrowed tongue (HP:0000221)1.68008776
142Dialeptic seizures (HP:0011146)1.67964516
143Type II lissencephaly (HP:0007260)1.67769550
144Recurrent abscess formation (HP:0002722)1.67342090
145Metaphyseal cupping (HP:0003021)1.66878212
146Premature ovarian failure (HP:0008209)1.66262197
147Hip dysplasia (HP:0001385)1.66069446
148Focal seizures (HP:0007359)1.65222947
149Hyperkalemia (HP:0002153)1.64298910
150Pheochromocytoma (HP:0002666)1.63055572
151Tubulointerstitial abnormality (HP:0001969)1.62562968
152Hyperaldosteronism (HP:0000859)1.62086636
153Stomach cancer (HP:0012126)1.61909749
154Personality changes (HP:0000751)1.61553219
155Sclerocornea (HP:0000647)1.60584362
156Limb hypertonia (HP:0002509)1.60397502
157IgA deficiency (HP:0002720)1.60316836
158Hemiparesis (HP:0001269)1.59207542
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.59172994
160Patellar aplasia (HP:0006443)1.58408534
161Abnormality of the duodenum (HP:0002246)1.58043323
162Spastic tetraparesis (HP:0001285)1.57815150
163Absent radius (HP:0003974)1.57582943
164Oculomotor apraxia (HP:0000657)1.56663316
165EMG: neuropathic changes (HP:0003445)1.56650581
166Clubbing of toes (HP:0100760)1.54677926
167Cleft eyelid (HP:0000625)1.54311366
168Tracheoesophageal fistula (HP:0002575)1.54074252
169Gastrointestinal inflammation (HP:0004386)1.52713458
170Irregular vertebral endplates (HP:0003301)1.52292573
171Gastrointestinal stroma tumor (HP:0100723)1.52250474
172Postaxial foot polydactyly (HP:0001830)1.51688286
173Chronic hepatic failure (HP:0100626)1.51209179
174Long foot (HP:0001833)1.50313236
175Inflammation of the large intestine (HP:0002037)1.49636918
176Truncal obesity (HP:0001956)1.48539728
177Severe visual impairment (HP:0001141)1.48253729
178Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.46658220
179Mild short stature (HP:0003502)1.46557041
180Lymphoma (HP:0002665)1.46175960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.44169841
2PDK35.25229411
3PDK45.25229411
4FRK4.70687821
5TLK13.98198546
6LATS13.89236950
7PDK23.42734003
8PRKD33.41692783
9TRPM72.92880972
10ICK2.91940010
11PIK3CA2.90794733
12NEK22.74625791
13WNK32.66995913
14EIF2AK32.65552822
15WEE12.63468713
16TAF12.52571001
17MAP4K22.47531231
18BUB12.43619943
19CDK192.41002231
20ACVR1B2.36286839
21PNCK2.27141750
22TTK2.20190196
23TEC2.16384797
24OXSR12.09666150
25MAP4K12.07604090
26NTRK31.94507385
27CDC71.89223826
28AKT31.86437658
29CASK1.84914064
30PASK1.76589614
31BMPR1B1.73848405
32KIT1.70856515
33CCNB11.68757383
34TESK21.68143512
35ADRBK21.54491426
36ITK1.52243044
37BMPR21.44321760
38CHEK21.43613908
39PHKG21.43202338
40PHKG11.43202338
41NUAK11.37139742
42PTK2B1.36632347
43ERBB31.30244579
44PLK11.27410988
45DYRK31.26143868
46EIF2AK11.22136386
47ZAK1.20568889
48ATR1.19455689
49BRAF1.17628973
50PLK41.16591759
51STK381.14440857
52EPHA21.12437862
53FGFR21.08939889
54PRPF4B1.08708718
55ALK1.06194122
56PDK11.05617610
57FER1.01190697
58CDK31.00849715
59GRK61.00527218
60MAP2K60.99205445
61MAPKAPK30.97754014
62TRIM280.97743843
63MARK10.96792991
64SRPK10.94222464
65CHEK10.93739001
66RIPK40.93253201
67TNIK0.93040279
68MAPK130.92524774
69PRKCI0.88925450
70EPHB20.88724557
71STK100.88681251
72NLK0.86597388
73MKNK20.86284882
74DAPK20.84690321
75ERBB20.84443532
76SIK20.82052495
77PLK30.81844890
78NEK10.78673751
79BLK0.78516455
80STK390.77279400
81BRSK20.75842691
82STK30.75820444
83CSF1R0.75580891
84PRKAA20.75525742
85AURKA0.73835195
86MUSK0.72708029
87CAMK1G0.71945782
88GRK70.71888997
89PRKCE0.69406535
90MAP3K130.67728237
91SYK0.67256837
92EIF2AK20.66668388
93TAOK20.66124979
94MAP3K100.65427198
95RET0.64094930
96ADRBK10.63451772
97CDK120.63197531
98BTK0.62356300
99DYRK1B0.61402042
100CDK40.61312592
101AURKB0.60944855
102TSSK60.60921104
103CDK70.60854100
104DAPK10.59903321
105CAMKK20.59730809
106PKN10.59123244
107MARK30.59009407
108EPHA30.58745541
109ATM0.58496470
110TNK20.57476330
111PAK10.56554309
112ABL10.55975775
113CLK10.55628198
114PRKG10.54792171
115IGF1R0.54628342
116PIM10.53296023
117NME10.52575617
118CDK20.52009552
119TGFBR10.51993595
120TXK0.50947242
121FGR0.50914300
122BCR0.50570125
123FES0.49510235
124GRK10.49216967
125MAP3K80.48548252
126MAP3K90.48160115
127CAMK1D0.46982963
128TAOK30.46263264
129CSNK2A20.46233547
130PRKCG0.44789413
131PRKCH0.43843331
132NTRK20.43697686
133MAP2K40.43318552
134STK160.43075036
135PIK3CG0.42897733
136WNK40.41365525
137CSNK1G10.40624417
138SCYL20.40471388
139LYN0.39502563
140IKBKB0.38872846
141MAPK150.37872746
142PDPK10.37620613
143CSNK2A10.37308048
144LCK0.37115662
145ARAF0.34701575
146CSNK1D0.34491007
147FGFR30.34445510
148CAMK2A0.34188181
149HCK0.34055759
150BRSK10.33962115
151MAP3K50.33784995
152CSK0.33152708
153PINK10.32698641
154PRKACA0.32485007
155TGFBR20.32355889
156STK38L0.31987138
157STK110.31854952
158MELK0.31420196
159PRKCZ0.30215116
160MAP3K140.29142744
161IRAK10.27643082
162ROCK10.26034590
163MATK0.25857012
164PAK30.25841292
165MAP3K40.25272265
166CDK10.24815943
167MAP3K60.24089765
168MAP2K70.24054060
169INSRR0.23662024
170TYK20.23509269
171MKNK10.23374403
172MARK20.22166474
173EPHA40.19652726
174PAK40.17635503
175PRKCD0.16039316

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54299087
2Mismatch repair_Homo sapiens_hsa034303.73405367
3RNA transport_Homo sapiens_hsa030133.12032083
4Phototransduction_Homo sapiens_hsa047443.11268875
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10617286
6Base excision repair_Homo sapiens_hsa034103.07830956
7Fanconi anemia pathway_Homo sapiens_hsa034603.02758585
8Proteasome_Homo sapiens_hsa030502.98307408
9Homologous recombination_Homo sapiens_hsa034402.93090417
10Caffeine metabolism_Homo sapiens_hsa002322.76619578
11Basal transcription factors_Homo sapiens_hsa030222.70512433
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54383702
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.46670292
14Pyrimidine metabolism_Homo sapiens_hsa002402.38929667
15African trypanosomiasis_Homo sapiens_hsa051432.36811088
16Spliceosome_Homo sapiens_hsa030402.31064160
17Nucleotide excision repair_Homo sapiens_hsa034202.27831095
18Nicotine addiction_Homo sapiens_hsa050332.24452033
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23683445
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.19932602
21RNA polymerase_Homo sapiens_hsa030202.18121054
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17981382
23Maturity onset diabetes of the young_Homo sapiens_hsa049502.14420659
24Non-homologous end-joining_Homo sapiens_hsa034502.09501428
25Allograft rejection_Homo sapiens_hsa053302.03229447
26Primary immunodeficiency_Homo sapiens_hsa053402.01712227
27Butanoate metabolism_Homo sapiens_hsa006502.00716131
28Tryptophan metabolism_Homo sapiens_hsa003801.99916691
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94144892
30Cell cycle_Homo sapiens_hsa041101.92583106
31Vitamin B6 metabolism_Homo sapiens_hsa007501.89595198
32Ether lipid metabolism_Homo sapiens_hsa005651.87566088
33mRNA surveillance pathway_Homo sapiens_hsa030151.85626433
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68251389
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66390604
36Propanoate metabolism_Homo sapiens_hsa006401.65486502
37Purine metabolism_Homo sapiens_hsa002301.64916319
38B cell receptor signaling pathway_Homo sapiens_hsa046621.64457655
39Antigen processing and presentation_Homo sapiens_hsa046121.63206194
40Nitrogen metabolism_Homo sapiens_hsa009101.60054814
41Autoimmune thyroid disease_Homo sapiens_hsa053201.55208163
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54545069
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53590416
44One carbon pool by folate_Homo sapiens_hsa006701.51845566
45Oocyte meiosis_Homo sapiens_hsa041141.51413922
46ABC transporters_Homo sapiens_hsa020101.49231361
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48595198
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.44402932
49Protein export_Homo sapiens_hsa030601.34219977
50Epstein-Barr virus infection_Homo sapiens_hsa051691.33384779
51Fructose and mannose metabolism_Homo sapiens_hsa000511.32243388
52Asthma_Homo sapiens_hsa053101.30727355
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22613496
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.18613957
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17928988
56Pentose phosphate pathway_Homo sapiens_hsa000301.17444279
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16487770
58Retinol metabolism_Homo sapiens_hsa008301.16220590
59RNA degradation_Homo sapiens_hsa030181.14409527
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11471670
61Pyruvate metabolism_Homo sapiens_hsa006201.10069087
62Morphine addiction_Homo sapiens_hsa050321.09484531
63Selenocompound metabolism_Homo sapiens_hsa004501.08862642
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07737131
65GABAergic synapse_Homo sapiens_hsa047271.07642085
66Salivary secretion_Homo sapiens_hsa049701.07518234
67Regulation of autophagy_Homo sapiens_hsa041401.05945082
68Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03716544
69Linoleic acid metabolism_Homo sapiens_hsa005911.02443408
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00259259
71Ribosome_Homo sapiens_hsa030100.99291134
72Herpes simplex infection_Homo sapiens_hsa051680.96535987
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95528099
74Sphingolipid metabolism_Homo sapiens_hsa006000.93928073
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92190495
76p53 signaling pathway_Homo sapiens_hsa041150.91519224
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.88779761
78Fat digestion and absorption_Homo sapiens_hsa049750.88354140
79Sulfur metabolism_Homo sapiens_hsa009200.87739812
80Peroxisome_Homo sapiens_hsa041460.87683132
81Hematopoietic cell lineage_Homo sapiens_hsa046400.85469620
82Fatty acid biosynthesis_Homo sapiens_hsa000610.84529676
83Chemical carcinogenesis_Homo sapiens_hsa052040.84131933
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83777019
85Collecting duct acid secretion_Homo sapiens_hsa049660.81740723
86Glucagon signaling pathway_Homo sapiens_hsa049220.79827747
87beta-Alanine metabolism_Homo sapiens_hsa004100.78931057
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77416725
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.76463262
90Huntingtons disease_Homo sapiens_hsa050160.76122671
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75722447
92Serotonergic synapse_Homo sapiens_hsa047260.73651348
93Legionellosis_Homo sapiens_hsa051340.73643308
94Amphetamine addiction_Homo sapiens_hsa050310.72940130
95Glutathione metabolism_Homo sapiens_hsa004800.72722800
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72283309
97Shigellosis_Homo sapiens_hsa051310.70776883
98Calcium signaling pathway_Homo sapiens_hsa040200.69897941
99Histidine metabolism_Homo sapiens_hsa003400.68037477
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67972794
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67142547
102Biosynthesis of amino acids_Homo sapiens_hsa012300.66442530
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.66385658
104Rheumatoid arthritis_Homo sapiens_hsa053230.65876336
105Olfactory transduction_Homo sapiens_hsa047400.65411023
106Carbon metabolism_Homo sapiens_hsa012000.64385997
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61611507
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61468961
109Oxidative phosphorylation_Homo sapiens_hsa001900.59276976
110Glutamatergic synapse_Homo sapiens_hsa047240.59081206
111N-Glycan biosynthesis_Homo sapiens_hsa005100.59034144
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58741718
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.55657801
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54289420
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.53410130
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53097382
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51244556
118Viral carcinogenesis_Homo sapiens_hsa052030.50949499
119cAMP signaling pathway_Homo sapiens_hsa040240.49560506
120Long-term potentiation_Homo sapiens_hsa047200.45922804
121Ovarian steroidogenesis_Homo sapiens_hsa049130.45870756
122Synaptic vesicle cycle_Homo sapiens_hsa047210.45634394
123Type II diabetes mellitus_Homo sapiens_hsa049300.44256235
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42729946
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40806359
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40768275
127Fatty acid degradation_Homo sapiens_hsa000710.40621102
128Insulin secretion_Homo sapiens_hsa049110.40442551
129Inositol phosphate metabolism_Homo sapiens_hsa005620.40037935
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39586467
131Systemic lupus erythematosus_Homo sapiens_hsa053220.39046715
132Type I diabetes mellitus_Homo sapiens_hsa049400.38201368
133Glycerolipid metabolism_Homo sapiens_hsa005610.37617097
134Dorso-ventral axis formation_Homo sapiens_hsa043200.35997875
135Tyrosine metabolism_Homo sapiens_hsa003500.35686938
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35415926
137HIF-1 signaling pathway_Homo sapiens_hsa040660.34846941
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.34328973
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34103054
140Graft-versus-host disease_Homo sapiens_hsa053320.33838025
141Measles_Homo sapiens_hsa051620.33426811
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33092687
143Pancreatic secretion_Homo sapiens_hsa049720.32086016
144Staphylococcus aureus infection_Homo sapiens_hsa051500.31308171
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30127514
146Other glycan degradation_Homo sapiens_hsa005110.29808445
147Influenza A_Homo sapiens_hsa051640.29615332
148Osteoclast differentiation_Homo sapiens_hsa043800.29337822
149Vitamin digestion and absorption_Homo sapiens_hsa049770.29202719
150Arachidonic acid metabolism_Homo sapiens_hsa005900.28709876
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28002177
152Renin-angiotensin system_Homo sapiens_hsa046140.27789693
153Mineral absorption_Homo sapiens_hsa049780.27443727
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26870262
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25881802
156HTLV-I infection_Homo sapiens_hsa051660.25394054
157Taste transduction_Homo sapiens_hsa047420.25261621
158Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24638973
159Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24618235
160Estrogen signaling pathway_Homo sapiens_hsa049150.23702591
161Circadian entrainment_Homo sapiens_hsa047130.22206566
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21375008
163Drug metabolism - other enzymes_Homo sapiens_hsa009830.21269009
164Adherens junction_Homo sapiens_hsa045200.20184252
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19368904
166Metabolic pathways_Homo sapiens_hsa011000.19232053
167Endocytosis_Homo sapiens_hsa041440.15572219
168Cardiac muscle contraction_Homo sapiens_hsa042600.15485362
169Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14383445
170Acute myeloid leukemia_Homo sapiens_hsa052210.14251814

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