ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.42205527
2	response to pheromone (GO:0019236)	6.05515285
3	L-fucose metabolic process (GO:0042354)	4.53249433
4	L-fucose catabolic process (GO:0042355)	4.53249433
5	fucose catabolic process (GO:0019317)	4.53249433
6	piRNA metabolic process (GO:0034587)	4.43822331
7	cellular ketone body metabolic process (GO:0046950)	4.41498362
8	ketone body metabolic process (GO:1902224)	3.92050886
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.91509916
10	protein polyglutamylation (GO:0018095)	3.86304810
11	DNA deamination (GO:0045006)	3.67727977
12	negative regulation of telomere maintenance (GO:0032205)	3.57430695
13	multicellular organism reproduction (GO:0032504)	3.57232446
14	sperm motility (GO:0030317)	3.52356495
15	indolalkylamine metabolic process (GO:0006586)	3.46795352
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.46302525
17	regulation of gene silencing by RNA (GO:0060966)	3.46053604
18	regulation of posttranscriptional gene silencing (GO:0060147)	3.46053604
19	regulation of gene silencing by miRNA (GO:0060964)	3.46053604
20	cytochrome complex assembly (GO:0017004)	3.37864309
21	epithelial cilium movement (GO:0003351)	3.25486795
22	protein complex biogenesis (GO:0070271)	3.21860476
23	rRNA catabolic process (GO:0016075)	3.20485454
24	nephron epithelium morphogenesis (GO:0072088)	3.18872720
25	nephron tubule morphogenesis (GO:0072078)	3.18872720
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.17752158
27	primary amino compound metabolic process (GO:1901160)	3.13720391
28	fusion of sperm to egg plasma membrane (GO:0007342)	3.11904451
29	cAMP catabolic process (GO:0006198)	3.11645134
30	ubiquinone biosynthetic process (GO:0006744)	3.09300567
31	DNA methylation involved in gamete generation (GO:0043046)	3.06811583
32	regulation of cilium movement (GO:0003352)	3.04038010
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01938688
34	sulfation (GO:0051923)	3.01163012
35	platelet dense granule organization (GO:0060155)	3.00312987
36	neuronal action potential (GO:0019228)	3.00078559
37	maturation of 5.8S rRNA (GO:0000460)	2.99194817
38	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98590240
39	tryptophan catabolic process (GO:0006569)	2.95365591
40	indole-containing compound catabolic process (GO:0042436)	2.95365591
41	indolalkylamine catabolic process (GO:0046218)	2.95365591
42	respiratory chain complex IV assembly (GO:0008535)	2.92199923
43	organic cation transport (GO:0015695)	2.91646749
44	detection of light stimulus involved in sensory perception (GO:0050962)	2.88571632
45	detection of light stimulus involved in visual perception (GO:0050908)	2.88571632
46	cilium or flagellum-dependent cell motility (GO:0001539)	2.86486780
47	indole-containing compound metabolic process (GO:0042430)	2.84996706
48	axoneme assembly (GO:0035082)	2.84798464
49	serotonin metabolic process (GO:0042428)	2.81723240
50	kynurenine metabolic process (GO:0070189)	2.81159405
51	mannosylation (GO:0097502)	2.81113954
52	ubiquinone metabolic process (GO:0006743)	2.79435988
53	acrosome reaction (GO:0007340)	2.77993593
54	alanine transport (GO:0032328)	2.76092560
55	gamma-aminobutyric acid transport (GO:0015812)	2.72551940
56	auditory receptor cell stereocilium organization (GO:0060088)	2.72379062
57	cyclic nucleotide catabolic process (GO:0009214)	2.71056545
58	histone H4-K12 acetylation (GO:0043983)	2.68800960
59	renal tubule morphogenesis (GO:0061333)	2.68610719
60	cellular biogenic amine catabolic process (GO:0042402)	2.67870710
61	amine catabolic process (GO:0009310)	2.67870710
62	regulation of action potential (GO:0098900)	2.66875706
63	neural tube formation (GO:0001841)	2.65537494
64	positive regulation of fatty acid transport (GO:2000193)	2.64860754
65	synaptic transmission, cholinergic (GO:0007271)	2.64525859
66	nonmotile primary cilium assembly (GO:0035058)	2.64389499
67	protein K11-linked deubiquitination (GO:0035871)	2.64117926
68	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61332680
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.59309638
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.59309638
71	NADH dehydrogenase complex assembly (GO:0010257)	2.59309638
72	male meiosis I (GO:0007141)	2.58227829
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.57668798
74	rhodopsin mediated signaling pathway (GO:0016056)	2.57343255
75	cilium movement (GO:0003341)	2.56985865
76	cornea development in camera-type eye (GO:0061303)	2.54736545
77	axonemal dynein complex assembly (GO:0070286)	2.53976142
78	plasma membrane fusion (GO:0045026)	2.53763216
79	tryptophan metabolic process (GO:0006568)	2.53601992
80	spermatid development (GO:0007286)	2.51404893
81	C4-dicarboxylate transport (GO:0015740)	2.50808502
82	GPI anchor metabolic process (GO:0006505)	2.50667653
83	pseudouridine synthesis (GO:0001522)	2.50143092
84	reflex (GO:0060004)	2.50129512
85	regulation of hexokinase activity (GO:1903299)	2.50056521
86	regulation of glucokinase activity (GO:0033131)	2.50056521
87	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.49665830
88	retinal cone cell development (GO:0046549)	2.48249306
89	positive regulation of prostaglandin secretion (GO:0032308)	2.47060631
90	rRNA modification (GO:0000154)	2.46405248
91	negative regulation of gene silencing (GO:0060969)	2.46267240
92	positive regulation of action potential (GO:0045760)	2.44354898
93	cilium morphogenesis (GO:0060271)	2.44215288
94	quinone biosynthetic process (GO:1901663)	2.43872800
95	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.41113150
96	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.39903659
97	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.39894148
98	protein-cofactor linkage (GO:0018065)	2.39466485
99	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.38283427
100	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.37055778

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70063698
2	VDR_22108803_ChIP-Seq_LS180_Human	3.45684770
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.06155445
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.65869038
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58016590
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.31791004
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23161587
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17678176
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16310688
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.02618571
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00225980
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95834777
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.91925472
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86272298
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85770048
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85390000
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83122543
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.82501220
19	FUS_26573619_Chip-Seq_HEK293_Human	1.78839024
20	P300_19829295_ChIP-Seq_ESCs_Human	1.77462948
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69417987
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65576451
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64896980
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64675163
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55168972
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51754942
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49057089
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.47850519
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47850519
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.46537105
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42749211
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.41631102
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.41307480
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39245018
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39198429
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39198429
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36594752
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34556567
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34086329
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34086329
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32281729
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32281729
43	EWS_26573619_Chip-Seq_HEK293_Human	1.30997581
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30915470
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30808124
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30386159
47	NCOR_22424771_ChIP-Seq_293T_Human	1.28838071
48	AR_25329375_ChIP-Seq_VCAP_Human	1.28389067
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28308864
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27243728
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27210990
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25407129
53	STAT3_23295773_ChIP-Seq_U87_Human	1.25366295
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25072551
55	TCF4_23295773_ChIP-Seq_U87_Human	1.24906103
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24717164
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24429166
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24398951
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23457025
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.23059745
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.22822370
62	ERA_21632823_ChIP-Seq_H3396_Human	1.22383060
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22332477
64	AR_20517297_ChIP-Seq_VCAP_Human	1.22158935
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21874092
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20402246
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20104355
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18780497
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.17900105
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17186555
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16307314
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.16071711
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.14686765
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14675318
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14615046
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13329325
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13066265
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12785118
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12617448
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11903844
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11817315
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09924382
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09784614
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09364553
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08729911
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07086326
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07026658
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06075700
89	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05157105
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04964099
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04620210
92	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.03821716
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02559788
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02331877
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01281349
96	GATA3_26560356_Chip-Seq_TH2_Human	1.01041708
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99765273
98	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99631727
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98601904
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98211751

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.04307955
2	MP0003646_muscle_fatigue	2.79373766
3	MP0008877_abnormal_DNA_methylation	2.44382795
4	MP0005551_abnormal_eye_electrophysiolog	2.42743751
5	MP0005410_abnormal_fertilization	2.38167061
6	MP0002837_dystrophic_cardiac_calcinosis	2.19016040
7	MP0002102_abnormal_ear_morphology	2.17979598
8	MP0009046_muscle_twitch	2.17829040
9	MP0005645_abnormal_hypothalamus_physiol	2.16821088
10	MP0008875_abnormal_xenobiotic_pharmacok	2.02381967
11	MP0001986_abnormal_taste_sensitivity	2.00865558
12	MP0003787_abnormal_imprinting	1.99756852
13	MP0004147_increased_porphyrin_level	1.96595008
14	MP0009745_abnormal_behavioral_response	1.96270925
15	MP0006292_abnormal_olfactory_placode	1.94568099
16	MP0001968_abnormal_touch/_nociception	1.94462231
17	MP0004043_abnormal_pH_regulation	1.90226179
18	MP0006072_abnormal_retinal_apoptosis	1.89874283
19	MP0008872_abnormal_physiological_respon	1.89114017
20	MP0001501_abnormal_sleep_pattern	1.87122567
21	MP0004885_abnormal_endolymph	1.81764371
22	MP0004142_abnormal_muscle_tone	1.80793305
23	MP0005379_endocrine/exocrine_gland_phen	1.79303829
24	MP0004145_abnormal_muscle_electrophysio	1.75378016
25	MP0002876_abnormal_thyroid_physiology	1.74049126
26	MP0000372_irregular_coat_pigmentation	1.68383280
27	MP0002272_abnormal_nervous_system	1.65459289
28	MP0001485_abnormal_pinna_reflex	1.62928678
29	MP0005377_hearing/vestibular/ear_phenot	1.59110001
30	MP0003878_abnormal_ear_physiology	1.59110001
31	MP0002163_abnormal_gland_morphology	1.59064068
32	MP0002638_abnormal_pupillary_reflex	1.57842910
33	MP0001486_abnormal_startle_reflex	1.53999518
34	MP0004133_heterotaxia	1.53623504
35	MP0005253_abnormal_eye_physiology	1.52786661
36	MP0004742_abnormal_vestibular_system	1.52703082
37	MP0002733_abnormal_thermal_nociception	1.52203925
38	MP0003011_delayed_dark_adaptation	1.50681115
39	MP0002736_abnormal_nociception_after	1.45467326
40	MP0002277_abnormal_respiratory_mucosa	1.45457404
41	MP0005671_abnormal_response_to	1.44733107
42	MP0006276_abnormal_autonomic_nervous	1.41873510
43	MP0002653_abnormal_ependyma_morphology	1.41854332
44	MP0005389_reproductive_system_phenotype	1.38852332
45	MP0002572_abnormal_emotion/affect_behav	1.36701437
46	MP0002064_seizures	1.36206937
47	MP0002928_abnormal_bile_duct	1.35620699
48	MP0001970_abnormal_pain_threshold	1.34197216
49	MP0003880_abnormal_central_pattern	1.31129235
50	MP0002160_abnormal_reproductive_system	1.30342585
51	MP0000427_abnormal_hair_cycle	1.28985634
52	MP0002557_abnormal_social/conspecific_i	1.28168747
53	MP0005646_abnormal_pituitary_gland	1.27970788
54	MP0005332_abnormal_amino_acid	1.27448330
55	MP0001984_abnormal_olfaction	1.27209201
56	MP0000631_abnormal_neuroendocrine_gland	1.26645907
57	MP0001919_abnormal_reproductive_system	1.24098743
58	MP0001905_abnormal_dopamine_level	1.23295457
59	MP0000569_abnormal_digit_pigmentation	1.22403316
60	MP0005084_abnormal_gallbladder_morpholo	1.20693122
61	MP0001502_abnormal_circadian_rhythm	1.16897965
62	MP0002735_abnormal_chemical_nociception	1.16008979
63	MP0003283_abnormal_digestive_organ	1.15473556
64	MP0003136_yellow_coat_color	1.14703500
65	MP0003698_abnormal_male_reproductive	1.14442383
66	MP0002234_abnormal_pharynx_morphology	1.13053911
67	MP0002938_white_spotting	1.12420008
68	MP0010386_abnormal_urinary_bladder	1.10306376
69	MP0002229_neurodegeneration	1.07994096
70	MP0001440_abnormal_grooming_behavior	1.06884785
71	MP0000230_abnormal_systemic_arterial	1.05540722
72	MP0002067_abnormal_sensory_capabilities	1.03713899
73	MP0003635_abnormal_synaptic_transmissio	1.02403508
74	MP0002909_abnormal_adrenal_gland	1.02277210
75	MP0001929_abnormal_gametogenesis	1.02218483
76	MP0008995_early_reproductive_senescence	1.02144793
77	MP0002063_abnormal_learning/memory/cond	1.01220470
78	MP0008775_abnormal_heart_ventricle	0.98531761
79	MP0000026_abnormal_inner_ear	0.95158053
80	MP0004019_abnormal_vitamin_homeostasis	0.92709233
81	MP0003252_abnormal_bile_duct	0.92511023
82	MP0003567_abnormal_fetal_cardiomyocyte	0.89853230
83	MP0005195_abnormal_posterior_eye	0.87102247
84	MP0001963_abnormal_hearing_physiology	0.85621079
85	MP0000685_abnormal_immune_system	0.84319208
86	MP0004924_abnormal_behavior	0.83468829
87	MP0005386_behavior/neurological_phenoty	0.83468829
88	MP0003718_maternal_effect	0.82311819
89	MP0002734_abnormal_mechanical_nocicepti	0.77999211
90	MP0004085_abnormal_heartbeat	0.77482506
91	MP0002693_abnormal_pancreas_physiology	0.77418311
92	MP0002148_abnormal_hypersensitivity_rea	0.75828726
93	MP0001765_abnormal_ion_homeostasis	0.74493802
94	MP0003137_abnormal_impulse_conducting	0.74346706
95	MP0004215_abnormal_myocardial_fiber	0.72947543
96	MP0002210_abnormal_sex_determination	0.72709674
97	MP0002752_abnormal_somatic_nervous	0.72607124
98	MP0006082_CNS_inflammation	0.71981504
99	MP0005636_abnormal_mineral_homeostasis	0.71523192
100	MP0008961_abnormal_basal_metabolism	0.71447476

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.56934078
2	Abnormality of midbrain morphology (HP:0002418)	4.10766470
3	Molar tooth sign on MRI (HP:0002419)	4.10766470
4	Pancreatic cysts (HP:0001737)	4.08563376
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.86102542
6	Pancreatic fibrosis (HP:0100732)	3.78708104
7	Nephronophthisis (HP:0000090)	3.69034413
8	Attenuation of retinal blood vessels (HP:0007843)	3.63832015
9	Abnormality of the renal cortex (HP:0011035)	3.46476056
10	True hermaphroditism (HP:0010459)	3.44687098
11	Abnormality of the renal medulla (HP:0100957)	3.26575488
12	Large for gestational age (HP:0001520)	3.22702007
13	Hyperventilation (HP:0002883)	3.18330468
14	Pendular nystagmus (HP:0012043)	2.92192312
15	Type II lissencephaly (HP:0007260)	2.90639556
16	Renal cortical cysts (HP:0000803)	2.86720518
17	Abnormal drinking behavior (HP:0030082)	2.78356438
18	Polydipsia (HP:0001959)	2.78356438
19	Increased corneal curvature (HP:0100692)	2.69766360
20	Keratoconus (HP:0000563)	2.69766360
21	Absent/shortened dynein arms (HP:0200106)	2.65708799
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.65708799
23	Cystic liver disease (HP:0006706)	2.62125502
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53436774
25	Medial flaring of the eyebrow (HP:0010747)	2.49608276
26	Bony spicule pigmentary retinopathy (HP:0007737)	2.49213158
27	Congenital, generalized hypertrichosis (HP:0004540)	2.46539873
28	Polyuria (HP:0000103)	2.43540625
29	Agitation (HP:0000713)	2.42242990
30	Abolished electroretinogram (ERG) (HP:0000550)	2.39726235
31	Limb dystonia (HP:0002451)	2.39309924
32	Broad-based gait (HP:0002136)	2.38631453
33	Severe visual impairment (HP:0001141)	2.35180931
34	Chronic hepatic failure (HP:0100626)	2.33968426
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33365603
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.33365603
37	Severe muscular hypotonia (HP:0006829)	2.31507281
38	Concave nail (HP:0001598)	2.30128111
39	Hypothermia (HP:0002045)	2.29900626
40	Tubular atrophy (HP:0000092)	2.27855122
41	Progressive cerebellar ataxia (HP:0002073)	2.27011588
42	Pachygyria (HP:0001302)	2.25286100
43	Decreased central vision (HP:0007663)	2.25281497
44	Lissencephaly (HP:0001339)	2.25238731
45	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.22816523
46	Hypoplasia of the fovea (HP:0007750)	2.20675867
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.20675867
48	Gaze-evoked nystagmus (HP:0000640)	2.20407042
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20354479
50	3-Methylglutaconic aciduria (HP:0003535)	2.18434655
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16531045
52	Sclerocornea (HP:0000647)	2.16329035
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11166976
54	Abnormality of alanine metabolism (HP:0010916)	2.11166976
55	Hyperalaninemia (HP:0003348)	2.11166976
56	Constricted visual fields (HP:0001133)	2.09907551
57	Abnormality of macular pigmentation (HP:0008002)	2.08991382
58	Furrowed tongue (HP:0000221)	2.08814419
59	Optic disc pallor (HP:0000543)	2.07455131
60	Hemiparesis (HP:0001269)	2.07084600
61	Abnormal urine output (HP:0012590)	2.02759557
62	Gait imbalance (HP:0002141)	2.00711184
63	Mitochondrial inheritance (HP:0001427)	1.99764212
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98835704
65	Abnormality of urine glucose concentration (HP:0011016)	1.98626186
66	Glycosuria (HP:0003076)	1.98626186
67	Asplenia (HP:0001746)	1.98075641
68	Genetic anticipation (HP:0003743)	1.97293887
69	Hypomagnesemia (HP:0002917)	1.95922114
70	Optic nerve hypoplasia (HP:0000609)	1.94789650
71	Inability to walk (HP:0002540)	1.91119243
72	Acute necrotizing encephalopathy (HP:0006965)	1.89274835
73	Male pseudohermaphroditism (HP:0000037)	1.88400589
74	Increased CSF lactate (HP:0002490)	1.88355183
75	Anencephaly (HP:0002323)	1.87695658
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.87527331
77	Abnormality of renal excretion (HP:0011036)	1.87423225
78	Bile duct proliferation (HP:0001408)	1.87069205
79	Abnormal biliary tract physiology (HP:0012439)	1.87069205
80	Abnormality of the fovea (HP:0000493)	1.86470902
81	Acute encephalopathy (HP:0006846)	1.83501371
82	Congenital primary aphakia (HP:0007707)	1.82560215
83	Abnormal ciliary motility (HP:0012262)	1.80305604
84	Stomach cancer (HP:0012126)	1.77741936
85	Hypoplasia of the uterus (HP:0000013)	1.77455716
86	Nephrogenic diabetes insipidus (HP:0009806)	1.76744093
87	Tetany (HP:0001281)	1.76127620
88	Focal motor seizures (HP:0011153)	1.74853445
89	Hyperglycinuria (HP:0003108)	1.72654724
90	Metabolic alkalosis (HP:0200114)	1.72239848
91	Congenital hepatic fibrosis (HP:0002612)	1.71717511
92	Febrile seizures (HP:0002373)	1.70880422
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69329158
94	Methylmalonic aciduria (HP:0012120)	1.68731719
95	Abnormal albumin level (HP:0012116)	1.68602133
96	Hypoalbuminemia (HP:0003073)	1.68602133
97	Tachypnea (HP:0002789)	1.68138321
98	Short tibia (HP:0005736)	1.67733102
99	Chorioretinal atrophy (HP:0000533)	1.66744784
100	Progressive macrocephaly (HP:0004481)	1.66727414

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.17502971
2	ADRBK2	3.56764824
3	TAOK3	3.25640789
4	INSRR	3.14518952
5	ZAK	3.09179686
6	MAP4K2	2.50647876
7	GRK1	2.46522287
8	PINK1	2.45416183
9	CASK	2.30916739
10	TLK1	2.29547750
11	WNK3	2.10452841
12	IRAK4	2.07525001
13	WNK4	1.97583677
14	TXK	1.92631682
15	MAPKAPK3	1.82594428
16	MAPK13	1.78046360
17	NUAK1	1.69837485
18	TAF1	1.68465394
19	PRKCI	1.52690649
20	OXSR1	1.47880568
21	BMPR1B	1.44584599
22	CAMKK2	1.40229270
23	STK39	1.34145072
24	PRKCG	1.33527874
25	PHKG1	1.30136482
26	PHKG2	1.30136482
27	ACVR1B	1.19042579
28	TIE1	1.18062046
29	BMPR2	1.17044158
30	MAP3K4	1.14850173
31	PIK3CG	1.14284340
32	PRKCE	1.14025187
33	DAPK2	1.11980494
34	MUSK	1.10654464
35	AKT3	1.07852448
36	MAPK15	1.05609229
37	MAP3K11	1.00007331
38	MARK1	0.99924087
39	RIPK1	0.97976064
40	BCKDK	0.97258661
41	PAK3	0.88318459
42	MAP2K6	0.86140232
43	TSSK6	0.86026922
44	MAP4K1	0.85881054
45	ADRBK1	0.85187849
46	MKNK2	0.84588899
47	STK38L	0.83729855
48	PRKCZ	0.83515207
49	MST4	0.79849513
50	PTK2B	0.78618254
51	IKBKB	0.78195179
52	GRK7	0.77183890
53	DYRK2	0.76785385
54	PRKCQ	0.76006183
55	DAPK1	0.73659075
56	TEC	0.72216388
57	MAP2K7	0.71133350
58	KIT	0.70263505
59	ITK	0.69447830
60	MAP3K12	0.68630635
61	PKN1	0.67659186
62	VRK1	0.65194198
63	NME1	0.64357292
64	TNIK	0.64098602
65	NTRK3	0.63148748
66	PLK4	0.61628392
67	PNCK	0.60705850
68	CAMK2A	0.59186741
69	CAMK1	0.56376134
70	PASK	0.56253944
71	SYK	0.56007566
72	GRK5	0.55616578
73	RPS6KA5	0.55335107
74	EPHA4	0.52876365
75	PIK3CA	0.52866662
76	CSNK1G2	0.51178334
77	PLK2	0.50912410
78	PRKD3	0.50806454
79	PRKACA	0.49708637
80	NTRK2	0.49589999
81	VRK2	0.49405733
82	ILK	0.47045317
83	FES	0.46523879
84	PRKG1	0.46311705
85	CSNK1G1	0.45057765
86	CSNK1G3	0.44841170
87	STK11	0.44417834
88	CSNK1A1	0.41908330
89	PRKCH	0.40570826
90	BRSK2	0.40134759
91	PRKCA	0.39789136
92	SIK2	0.39425113
93	CDK3	0.38319945
94	MARK3	0.36188792
95	ERBB3	0.35777132
96	PRKCD	0.35591939
97	MAP2K2	0.35219548
98	GRK6	0.34943071
99	DAPK3	0.31344272
100	OBSCN	0.29791854

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.95276380
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.88260909
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64134481
4	Butanoate metabolism_Homo sapiens_hsa00650	2.45699120
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.45545418
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44301719
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.41471906
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33621847
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30527309
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15392936
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.11450887
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.09116553
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07416084
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.06417089
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95614929
16	Olfactory transduction_Homo sapiens_hsa04740	1.95603388
17	Nicotine addiction_Homo sapiens_hsa05033	1.92985489
18	Parkinsons disease_Homo sapiens_hsa05012	1.76557273
19	Regulation of autophagy_Homo sapiens_hsa04140	1.57691602
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.56422217
21	Caffeine metabolism_Homo sapiens_hsa00232	1.51294713
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.47905734
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.47499658
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.43114712
25	Protein export_Homo sapiens_hsa03060	1.42663365
26	Morphine addiction_Homo sapiens_hsa05032	1.39001167
27	RNA polymerase_Homo sapiens_hsa03020	1.37078112
28	Sulfur relay system_Homo sapiens_hsa04122	1.36544154
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.35479876
30	Taste transduction_Homo sapiens_hsa04742	1.35439069
31	RNA degradation_Homo sapiens_hsa03018	1.24720066
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24271385
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23236404
34	Alzheimers disease_Homo sapiens_hsa05010	1.20743179
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.20664431
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20643265
37	Homologous recombination_Homo sapiens_hsa03440	1.17508998
38	Peroxisome_Homo sapiens_hsa04146	1.15695423
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11032487
40	Allograft rejection_Homo sapiens_hsa05330	1.09709398
41	Huntingtons disease_Homo sapiens_hsa05016	1.09474771
42	Insulin secretion_Homo sapiens_hsa04911	1.08853148
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05334229
44	Basal transcription factors_Homo sapiens_hsa03022	1.03538710
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.02428018
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00117560
47	Retinol metabolism_Homo sapiens_hsa00830	0.98908066
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97530852
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.97415644
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96696069
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96049719
52	Serotonergic synapse_Homo sapiens_hsa04726	0.95341296
53	GABAergic synapse_Homo sapiens_hsa04727	0.95259868
54	Asthma_Homo sapiens_hsa05310	0.93069109
55	Circadian entrainment_Homo sapiens_hsa04713	0.92199780
56	Fatty acid elongation_Homo sapiens_hsa00062	0.90782424
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.88239456
58	Propanoate metabolism_Homo sapiens_hsa00640	0.87739187
59	One carbon pool by folate_Homo sapiens_hsa00670	0.84682703
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83286040
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81089355
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80963925
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80781738
64	Salivary secretion_Homo sapiens_hsa04970	0.78534695
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77795273
66	ABC transporters_Homo sapiens_hsa02010	0.77676902
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.75823386
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73094287
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.72879904
70	Purine metabolism_Homo sapiens_hsa00230	0.68857155
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68472462
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67430689
73	Mineral absorption_Homo sapiens_hsa04978	0.66710505
74	Ribosome_Homo sapiens_hsa03010	0.64282219
75	Proteasome_Homo sapiens_hsa03050	0.63539499
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.60492020
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60310120
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.58846837
79	Metabolic pathways_Homo sapiens_hsa01100	0.57702680
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56600367
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55859569
82	Histidine metabolism_Homo sapiens_hsa00340	0.53395205
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51048793
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50832128
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48769448
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48662791
87	Circadian rhythm_Homo sapiens_hsa04710	0.48174329
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.46361753
89	Sulfur metabolism_Homo sapiens_hsa00920	0.46041259
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45123019
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45042631
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43706905
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43277394
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38521635
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36531013
96	Gastric acid secretion_Homo sapiens_hsa04971	0.33211503
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.32078981
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31286767
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.31280644
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29083396

NPAP1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »